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Anaesthesia lasted 130 min, with a surgery duration of 75 min. No surgical complications were reported. Except for a period of 10 min after induction in which MAP values were around 60 mmHg, no other events or abnormalities on the ECG, HR or MAP were observed during anaesthesia. Ninety minutes after induction, morphine 0.1 mg kg −1 IM was administered, and the lidocaine CRI was stopped 20 min before the end of anaesthesia. Ten minutes later, the horse was weaned from the ventilator. At the end of the surgical procedure, 5 min before the end of anaesthesia, the intra-arterial catheter was removed, fluids were stopped but the IV catheter was kept for recovery. The vaporizer and oxygen were switched off; the horse was disconnected from the monitoring devices and from the breathing system but remained orotracheally intubated. While the horse was attached to a hoist and positioned on dorsal recumbency, a romifidine 0.02 mg kg −1 IV bolus was given, and the horse moved thereafter to the recovery box. Once there, the horse was positioned on right lateral recumbency on a padded floor, with the anaesthetist at its head to check vital signs and avoid premature attempts of rising. The time from the end of anaesthesia to this point was approximately 2 min. Despite the horse was breathing spontaneously before its transfer, apnoea was noticed when positioned in the recovery box. At physical examination, pulse was absent, mucous membranes were greyish, and pupils mydriatic. Cardiac auscultation confirmed the absence of cardiac beats. The time was noted, and thoracic compressions were immediately started by an operator jumping with his knees on the mare's thorax. Three persons (weighting 60, 80, and > 90 kg, respectively) rotated every 2 min to perform the external massage. The third heavier operator performed massage by rhythmically and energetically sitting on the horse's thorax. Meanwhile, 6 mg of adrenaline (Adrenaline Aguettant®, Aguettant, France) was administered IV, followed by 5 mL of heparinised saline. Mechanical ventilation was provided with a demand valve at a rate of 10 breaths min −1 , with 100 % oxygen and Ringer Lactate was administered at 10 mL kg −1 hour −1 . Vital parameters were continuously monitored by mandibular pulse palpation, eye reflexes evaluation. While the third operator was performing the external massage, mandibular pulse was detectable and synchronous to the thoracic compressions. A multiparameter monitor was then connected for ECG, HR, and non-invasive blood pressure measurements, with a cuff on the left metacarpal bone. However, due to the movements on the patient, monitoring assessment was difficult. Five minutes after the start of CPR, the anaesthetist detected a stronger mandibular pulse, asynchronous to the external massage. Thoracic compressions were stopped, and the anaesthetist confirmed the presence of normal QRS complexes on the ECG, whereas the horse was still apnoeic. Mechanical ventilation was continued with the demand valve with a respiratory rate of 6 breaths min −1 . The mare was initially tachycardic (HR of 60 beats min −1 ), with a sinus rhythm, and MAP of 80 mmHg. Within the next 10 min, HR decreased to 37 beats min −1 and MAP dropped to 50 mmHg with a poor pulse quality. Dobutamine CRI was thus administered to effect at 0.5 to 2 μg kg −1 min −1 IV for 5 min, until MAP reached 70 mmHg, and stopped thereafter. Ten minutes after the return of spontaneous circulation, spontaneous breathing reappeared. Afterwards, IPPV was stopped but oxygen supplementation was continued using a flow-by method, with an oxygen supply tubing positioned in the endotracheal tube and an oxygen flow set at 12 L min −1 . At this time, pupillary reflex was present, but not palpebral reflex. Capillary refill time was less than 2 sec and SpO 2 100%, but mucous membranes remained pale pink and sweating was present. An arterial blood gas analysis was carried out and revealed a non-compensated respiratory acidosis (pH 7.3; arterial pressure of carbon dioxide (PaCO 2 ) 67 mmHg; bicarbonate, 29 mmol L −1 ; anion gap 14 mmol L −1 , base excess 0 mmol L −1 ). Palpebral reflex and nystagmus were noticed 15 min after the return to spontaneous circulation. Ten minutes later, reflexes became stronger and the horse started presenting some movements, which were controlled by two operators at the head to avoid premature standing. The endotracheal tube was secured to the horse's mouth and all equipment was removed from the box to prepare for the recovery, which was assisted with ropes. The mare stood up at the first attempt 1 h after the start of CPR, and remained quiet thereafter, although trembling. The patient was then extubated and kept in the recovery box for close observation. Two hours later, the mare was transferred to the hospitalization box and received phenylbutazone 4.4 mg kg −1 IV and omeprazole (Gastrogard, Merial, France) 2.2 mg kg −1 , orally. Venous blood sample analysis revealed a lactate into the normal range (1.3 mmol L −1 ) and mild increased creatinine kinase (751 IU L −1 ). Neurological examination was normal thereafter: the horse was alert with normal pupillary reflexes, no apparent blindness, deafness or ataxia.
| 4.070313
| 0.816406
|
sec[1]/p[5]
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29988384
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https://doi.org/10.3389/fvets.2018.00138
|
[
"horse",
"anaesthesia",
"mmhg",
"minutes",
"recovery",
"oxygen",
"pulse",
"positioned",
"thereafter",
"time"
] |
[
{
"code": "NC76.1Z",
"title": "Injury of quadriceps muscle or tendon, unspecified"
},
{
"code": "NE61",
"title": "Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified"
},
{
"code": "LB30.62",
"title": "Horseshoe kidney"
},
{
"code": "PA0E",
"title": "Unintentional land transport traffic event injuring a rider of an animal"
},
{
"code": "PA1E",
"title": "Unintentional land transport nontraffic event injuring a rider of an animal"
},
{
"code": "MB40.3",
"title": "Anaesthesia of skin"
},
{
"code": "9A78.6",
"title": "Anaesthesia of cornea"
},
{
"code": "MG30.5Z",
"title": "Chronic neuropathic pain, unspecified"
},
{
"code": "JA67.Z",
"title": "Complications of anaesthesia during pregnancy, unspecified"
},
{
"code": "JB43.Z",
"title": "Complications of anaesthesia during the puerperium, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[NC76.1Z] Injury of quadriceps muscle or tendon, unspecified
Also known as: Injury of quadriceps muscle or tendon, unspecified | Injury of quadriceps muscle or tendon | charley-horse
[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified
Also known as: Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified | Harmful effects of or exposure to noxious substances chiefly nonmedicinal as to source, alcohols | alcohol poisoning | alcohol toxicity | Harmful effects of or exposure to noxious substances chiefly nonmedicinal as to source, Ethanol
Excludes: corrosions | Bacterial foodborne intoxications
[LB30.62] Horseshoe kidney
Definition: Horseshoe kidney is the most frequent renal fusion anomaly and is characterised by the union of the inferior poles of the two kidneys through an isthmus. Horseshoe kidney is in fact an anatomical anomaly rather than a disease, but it does lead to predisposition to certain conditions such as hydronephrosis, nephrolithiasis or pyelonephritis. One third of individuals with horseshoe kidney are asymptomatic, with the anomaly being discovered fortuitously during a radiological examination. Urogenital
Also known as: Horseshoe kidney | Congenital horseshoe kidney | Ren unguliformis | Ren arcuatus
[PA0E] Unintentional land transport traffic event injuring a rider of an animal
Also known as: Unintentional land transport traffic event injuring a rider of an animal | Fall from horse in traffic event
[PA1E] Unintentional land transport nontraffic event injuring a rider of an animal
Also known as: Unintentional land transport nontraffic event injuring a rider of an animal | Fall from horse in nontraffic event
[MB40.3] Anaesthesia of skin
Definition: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy.
Also known as: Anaesthesia of skin | Hypoaesthesia of skin | Loss of cutaneous sensation | Numbness of skin | Loss of sensation
Includes: Numbness of skin
[9A78.6] Anaesthesia of cornea
Definition: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber.
Also known as: Anaesthesia of cornea | corneal anaesthesia
[MG30.5Z] Chronic neuropathic pain, unspecified
Also known as: Chronic neuropathic pain, unspecified | Chronic neuropathic pain | anaesthesia dolorosa | neuralgia | chronic neurogenic pain (deprecated)
[JA67.Z] Complications of anaesthesia during pregnancy, unspecified
Also known as: Complications of anaesthesia during pregnancy, unspecified | Complications of anaesthesia during pregnancy
[JB43.Z] Complications of anaesthesia during the puerperium, unspecified
Also known as: Complications of anaesthesia during the puerperium, unspecified | Complications of anaesthesia during the puerperium
=== GRAPH WALKS ===
--- Walk 1 ---
[NC76.1Z] Injury of quadriceps muscle or tendon, unspecified
--PARENT--> [NC76.1] Injury of quadriceps muscle or tendon
--CHILD--> [NC76.10] Strain or sprain of quadriceps muscle or tendon
--- Walk 2 ---
[NC76.1Z] Injury of quadriceps muscle or tendon, unspecified
--PARENT--> [NC76.1] Injury of quadriceps muscle or tendon
--CHILD--> [NC76.11] Laceration of quadriceps muscle or tendon
--- Walk 3 ---
[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified
--EXCLUDES--> [?] Burns
Def: A burn is an injury to the tissues caused by a pathological flux of energy which causes cellular destruction and irreversible denaturation of proteins and is primarily caused by thermal or other acute...
--EXCLUDES--> [?] Adverse cutaneous effects of therapeutic ionizing irradiation
--- Walk 4 ---
[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified
--EXCLUDES--> [?] Burns
Def: A burn is an injury to the tissues caused by a pathological flux of energy which causes cellular destruction and irreversible denaturation of proteins and is primarily caused by thermal or other acute...
--EXCLUDES--> [?] Sunburn
Def: An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight....
--- Walk 5 ---
[LB30.62] Horseshoe kidney
Def: Horseshoe kidney is the most frequent renal fusion anomaly and is characterised by the union of the inferior poles of the two kidneys through an isthmus. Horseshoe kidney is in fact an anatomical anom...
--PARENT--> [LB30.6] Fusion anomaly of kidneys
Def: The embryological, incomplete fusion of renal lobules and/or kidneys...
--PARENT--> [LB30] Structural developmental anomalies of kidneys
Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....
--- Walk 6 ---
[LB30.62] Horseshoe kidney
Def: Horseshoe kidney is the most frequent renal fusion anomaly and is characterised by the union of the inferior poles of the two kidneys through an isthmus. Horseshoe kidney is in fact an anatomical anom...
--PARENT--> [LB30.6] Fusion anomaly of kidneys
Def: The embryological, incomplete fusion of renal lobules and/or kidneys...
--CHILD--> [LB30.61] Fused pelvic kidney
Def: A condition caused by failure of the kidneys to correctly develop during the antenatal period. This condition is characterised by the presence of a single kidney, along the midline of the body. This c...
|
[
"[NC76.1Z] Injury of quadriceps muscle or tendon, unspecified\n --PARENT--> [NC76.1] Injury of quadriceps muscle or tendon\n --CHILD--> [NC76.10] Strain or sprain of quadriceps muscle or tendon",
"[NC76.1Z] Injury of quadriceps muscle or tendon, unspecified\n --PARENT--> [NC76.1] Injury of quadriceps muscle or tendon\n --CHILD--> [NC76.11] Laceration of quadriceps muscle or tendon",
"[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified\n --EXCLUDES--> [?] Burns\n Def: A burn is an injury to the tissues caused by a pathological flux of energy which causes cellular destruction and irreversible denaturation of proteins and is primarily caused by thermal or other acute...\n --EXCLUDES--> [?] Adverse cutaneous effects of therapeutic ionizing irradiation",
"[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified\n --EXCLUDES--> [?] Burns\n Def: A burn is an injury to the tissues caused by a pathological flux of energy which causes cellular destruction and irreversible denaturation of proteins and is primarily caused by thermal or other acute...\n --EXCLUDES--> [?] Sunburn\n Def: An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight....",
"[LB30.62] Horseshoe kidney\n Def: Horseshoe kidney is the most frequent renal fusion anomaly and is characterised by the union of the inferior poles of the two kidneys through an isthmus. Horseshoe kidney is in fact an anatomical anom...\n --PARENT--> [LB30.6] Fusion anomaly of kidneys\n Def: The embryological, incomplete fusion of renal lobules and/or kidneys...\n --PARENT--> [LB30] Structural developmental anomalies of kidneys\n Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....",
"[LB30.62] Horseshoe kidney\n Def: Horseshoe kidney is the most frequent renal fusion anomaly and is characterised by the union of the inferior poles of the two kidneys through an isthmus. Horseshoe kidney is in fact an anatomical anom...\n --PARENT--> [LB30.6] Fusion anomaly of kidneys\n Def: The embryological, incomplete fusion of renal lobules and/or kidneys...\n --CHILD--> [LB30.61] Fused pelvic kidney\n Def: A condition caused by failure of the kidneys to correctly develop during the antenatal period. This condition is characterised by the presence of a single kidney, along the midline of the body. This c..."
] |
NC76.1Z
|
Injury of quadriceps muscle or tendon, unspecified
|
[
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76112A",
"icd10_title": "Strain of left quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76111A",
"icd10_title": "Strain of right quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76191A",
"icd10_title": "Other specified injury of right quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76121A",
"icd10_title": "Laceration of right quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76122A",
"icd10_title": "Laceration of left quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76111D",
"icd10_title": "Strain of right quadriceps muscle, fascia and tendon, subsequent encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76192D",
"icd10_title": "Other specified injury of left quadriceps muscle, fascia and tendon, subsequent encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S76192A",
"icd10_title": "Other specified injury of left quadriceps muscle, fascia and tendon, initial encounter"
},
{
"from_icd11": "NC76.1Z",
"icd10_code": "S761",
"icd10_title": "Injury of quadriceps muscle, fascia and tendon"
},
{
"from_icd11": "NE61",
"icd10_code": "T5802XA",
"icd10_title": "Toxic effect of carbon monoxide from motor vehicle exhaust, intentional self-harm, initial encounter"
},
{
"from_icd11": "NE61",
"icd10_code": "T550X2A",
"icd10_title": "Toxic effect of soaps, intentional self-harm, initial encounter"
},
{
"from_icd11": "NE61",
"icd10_code": "T61781A",
"icd10_title": "Other shellfish poisoning, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE61",
"icd10_code": "T551X2A",
"icd10_title": "Toxic effect of detergents, intentional self-harm, initial encounter"
},
{
"from_icd11": "NE61",
"icd10_code": "T5891XA",
"icd10_title": "Toxic effect of carbon monoxide from unspecified source, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE61",
"icd10_code": "T63711A",
"icd10_title": "Toxic effect of contact with venomous marine plant, accidental (unintentional), initial encounter"
}
] |
S76112A
|
Strain of left quadriceps muscle, fascia and tendon, initial encounter
|
A 55-year-old man who had a history of hypertension was admitted to the neurosurgery department due to dizziness repeatedly for over a year and a sudden onset of syncope 1 month prior. Additionally, he once accepted medical therapy in the neurological department without alleviation. Neurological examination revealed no abnormal signs. Diffusion-weighted imaging (DWI) showed no obvious infarct in the bilateral cerebral cortex. Ultrasound examination of the carotid artery confirmed chronic bilateral stenosis of the carotid artery bifurcation caused by stable fibrous-calcific plaques. In contrast to the normal side, left stenotic anterior cerebral arteries (ACA), middle cerebral artery (MCA) and ICA were hardly detected on preoperative DSA . The left frontal and parietal lobes were mainly supplied by the left posterior cerebral artery without obvious moyamoya vessels in skull base . Preoperative DSA confirmed the frontal and parietal branches of superficial temporal artery (STA) which originates from the external carotid artery deep to the superficial pole of the parotid and ascends anterior to the auditory canal . Magnetic resonance imaging 3D–arterial spin labeling (MRI 3D-ASL) indicated decreased cerebral blood flow (CBF) in the left cerebral cortex . Dual anastomosis between the superficial temporal artery (STA) and middle cerebral artery (MCA) combined with EDMS on the left side was performed. The patency of the anastomotic stoma was immediately confirmed by indocyanine green video-angiography. Accompanied by nicardipine hydrochloride, systolic blood pressure was strictly controlled at 120–140 mmHg promptly after surgery. During the first few days, the patient presented no additional neurological deterioration. Computed tomography angiography after surgery confirmed no stenosis in recipient vessels. Additionally, T2-weighed MRI and 3D-ASL on the 3rd day after surgery showed a more significantly increased CBF at the anastomosis sites than at the preoperative stage , indicating the effectiveness of revascularization. Nevertheless, this patient developed aphasia and right hemiplegia on the 6th day after surgery with continuous execution of the strict program of blood pressure control. Computed tomography on the same day found that the middle line migrated to the right side and a local low-density lesion in the left frontal lobe near the operative area. Following the application of mannitol and furosemide, the symptoms began to ameliorate on the 16th day after surgery. Nevertheless, MRI 3D-ASL on the 21st day after surgery showed more decreased CBF than at the site of anastomosis on the 3rd day after surgery . T2-weighted MRI showed a massive hyperintensity lesion around the operation area, while DWI revealed no cerebral infarction, indicating massive cerebral edema in the operative area . Ultimately, this patient recovered after 40 days of surgery without any neurologic deficits. MRI 3D-ASL on the 166th day showed bilateral well-developed CBF and DSA on the 180th day presented well-developed revascularization . Fig. 1 Digital subtraction angiography (DSA) results of the patient. a . Steno-occlusive changes at the bifurcation of the left carotid artery and abnormal development of the left ACA and MCA with a normal right ICA on preoperative DSA. b . Left frontal and partial lobes mainly supplied by the left posterior cerebral artery on preoperative DSA. c . Distribution of the superficial temporal artery before bypass surgery. The black arrows indicate the frontal and parietal branches of STA. d . The superficial temporal artery grew well and participated in supplying the left temporal and partial lobes in DSA examined at 6 months after surgery Fig. 2 The changes of cerebral blood flow. a . Left cerebral perfusion is lower than right cerebral perfusion on preoperative magnetic resonance imaging 3D–arterial spin labeling (MRI 3D-ASL). b . T2-weighted magnetic resonance imaging showed mild focal cerebral edema in the operative area and a swollen temporal muscle on the 3rd day after surgery (The black arrow indicates cerebral edema at the sites of anastomosis). c . MRI 3D-ASL showed increased cerebral blood flow (CBF) at the sites of anastomosis with mildly increased CBF of the adjacent cerebral cortex on the 3rd day after surgery (The black arrow indicates increased CBF at the sites of anastomosis). d . MRI 3D-ASL shows high CBFs in the region distributed by dual recipient vessels compared with the adjacent cerebral cortex, while cerebral perfusion of the whole brain displays a relative low level on the 21st day after surgery (The black arrow indicates high CBFs, and the red circle indicates the region of interest of the middle cerebral artery (MCA) distribution). e . MRI 3D-ASL examined at 6 months after surgery shows good improvement on the left side and a normal level on the right side Fig. 3 Postoperative magnetic resonance imaging (MRI) findings. a . and b . T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging indicate no infarction occurred on the left side, but massive cerebral edema on the 10th day after surgery. c . T1-weighted MRI showed mild migration of the middle line on the 21st day after surgery
| 4.074219
| 0.974121
|
sec[1]/p[0]
|
en
| 0.999998
|
32891141
|
https://doi.org/10.1186/s12883-020-01912-z
|
[
"cerebral",
"artery",
"imaging",
"weighted",
"side",
"preoperative",
"temporal",
"anastomosis",
"middle",
"frontal"
] |
[
{
"code": "1D00.Z",
"title": "Infectious encephalitis, unspecified"
},
{
"code": "8E7Y",
"title": "Other specified diseases of the nervous system"
},
{
"code": "8B20",
"title": "Stroke not known if ischaemic or haemorrhagic"
},
{
"code": "8B1Z",
"title": "Cerebral ischaemia, unspecified"
},
{
"code": "8B11.5Z",
"title": "Cerebral ischaemic stroke, unspecified"
},
{
"code": "BD5Z",
"title": "Diseases of arteries or arterioles, unspecified"
},
{
"code": "BD52",
"title": "Certain specified disorders of arteries or arterioles"
},
{
"code": "BD52.3",
"title": "Rupture of artery"
},
{
"code": "BD52.2",
"title": "Stricture of artery"
},
{
"code": "BD40.Z",
"title": "Atherosclerotic chronic arterial occlusive disease, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[1D00.Z] Infectious encephalitis, unspecified
Also known as: Infectious encephalitis, unspecified | Infectious encephalitis, not elsewhere classified | encephalitis NOS | acute encephalitis NOS | acute brain inflammation
[8E7Y] Other specified diseases of the nervous system
Also known as: Other specified diseases of the nervous system | Circumscribed brain atrophy | circumscribed cerebral atrophy | atrophic lobar sclerosis | atrophic lobar brain sclerosis
[8B20] Stroke not known if ischaemic or haemorrhagic
Definition: Fulfills criteria for stroke in acute symptoms of focal brain injury that have lasted 24 hours or more (or led to death before 24 hours), but subtype of stroke (ischemic or haemorrhagic) has not been determined by neuroimaging or other techniques.
Also known as: Stroke not known if ischaemic or haemorrhagic | apoplexy | brain vascular accident | cerebral accident | cerebral apoplexy
Excludes: sequelae of stroke
[8B1Z] Cerebral ischaemia, unspecified
Also known as: Cerebral ischaemia, unspecified | brain ischaemia | cerebrovascular ischaemic disease | cerebrovascular ischaemia | cerebral anaemia
[8B11.5Z] Cerebral ischaemic stroke, unspecified
Also known as: Cerebral ischaemic stroke, unspecified | Cerebral ischaemic stroke of unknown cause | cryptogenic stroke | occlusion and stenosis of cerebral and precerebral arteries, resulting in cerebral infarction | cerebral infarct
[BD5Z] Diseases of arteries or arterioles, unspecified
Also known as: Diseases of arteries or arterioles, unspecified | artery disease NOS | arterial disease NOS | arteriolar disease NOS | disorder of artery NOS
[BD52] Certain specified disorders of arteries or arterioles
Also known as: Certain specified disorders of arteries or arterioles | Aortic dilatation - joint hypermobility - arterial tortuosity | Generalised arterial calcification of infancy | Median arcuate ligament syndrome | Aortic root abscess
Excludes: collagen (vascular) diseases | Hypersensitivity angiitis | Acute arterial occlusion
[BD52.3] Rupture of artery
Also known as: Rupture of artery | ruptured artery | artery fistula | Aortic duodenal fistula | Aortic colon fistula
Excludes: traumatic rupture of artery - see injury of blood vessel by body region
[BD52.2] Stricture of artery
Also known as: Stricture of artery | arterial stenosis | arterial stricture | artery stricture | stenosis of artery
[BD40.Z] Atherosclerotic chronic arterial occlusive disease, unspecified
Also known as: Atherosclerotic chronic arterial occlusive disease, unspecified | Atherosclerotic chronic arterial occlusive disease | arteriosclerosis, NOS | generalised atherosclerosis | atherosclerosis NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[1D00.Z] Infectious encephalitis, unspecified
--PARENT--> [1D00] Infectious encephalitis, not elsewhere classified
Def: A disease of the brain, caused by an infection....
--CHILD--> [1D00.2] Parasitic or protozoal encephalitis
Def: A disease of the brain, caused by an infection with a parasitic or protozoal source....
--- Walk 2 ---
[1D00.Z] Infectious encephalitis, unspecified
--PARENT--> [1D00] Infectious encephalitis, not elsewhere classified
Def: A disease of the brain, caused by an infection....
--CHILD--> [1D00.0] Bacterial encephalitis
--- Walk 3 ---
[8E7Y] Other specified diseases of the nervous system
--PARENT--> [08] Diseases of the nervous system
Def: This is a group of conditions characterised as being in or associated with the nervous system....
--EXCLUDES--> [?] Certain conditions originating in the perinatal period
Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....
--- Walk 4 ---
[8E7Y] Other specified diseases of the nervous system
--PARENT--> [08] Diseases of the nervous system
Def: This is a group of conditions characterised as being in or associated with the nervous system....
--RELATED_TO--> [?] Structural developmental anomalies of the nervous system
Def: Any condition caused by failure of the nervous system to correctly develop during the antenatal period....
--- Walk 5 ---
[8B20] Stroke not known if ischaemic or haemorrhagic
Def: Fulfills criteria for stroke in acute symptoms of focal brain injury that have lasted 24 hours or more (or led to death before 24 hours), but subtype of stroke (ischemic or haemorrhagic) has not been ...
--EXCLUDES--> [?] Late effects of stroke not known if ischaemic or haemorrhagic
Def: Late effects occurring 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episodes....
--PARENT--> [?] Late effects of cerebrovascular disease
Def: Effects of cerebrovascular disease 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episo...
--- Walk 6 ---
[8B20] Stroke not known if ischaemic or haemorrhagic
Def: Fulfills criteria for stroke in acute symptoms of focal brain injury that have lasted 24 hours or more (or led to death before 24 hours), but subtype of stroke (ischemic or haemorrhagic) has not been ...
--EXCLUDES--> [?] Late effects of stroke not known if ischaemic or haemorrhagic
Def: Late effects occurring 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episodes....
--PARENT--> [?] Late effects of cerebrovascular disease
Def: Effects of cerebrovascular disease 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episo...
|
[
"[1D00.Z] Infectious encephalitis, unspecified\n --PARENT--> [1D00] Infectious encephalitis, not elsewhere classified\n Def: A disease of the brain, caused by an infection....\n --CHILD--> [1D00.2] Parasitic or protozoal encephalitis\n Def: A disease of the brain, caused by an infection with a parasitic or protozoal source....",
"[1D00.Z] Infectious encephalitis, unspecified\n --PARENT--> [1D00] Infectious encephalitis, not elsewhere classified\n Def: A disease of the brain, caused by an infection....\n --CHILD--> [1D00.0] Bacterial encephalitis",
"[8E7Y] Other specified diseases of the nervous system\n --PARENT--> [08] Diseases of the nervous system\n Def: This is a group of conditions characterised as being in or associated with the nervous system....\n --EXCLUDES--> [?] Certain conditions originating in the perinatal period\n Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....",
"[8E7Y] Other specified diseases of the nervous system\n --PARENT--> [08] Diseases of the nervous system\n Def: This is a group of conditions characterised as being in or associated with the nervous system....\n --RELATED_TO--> [?] Structural developmental anomalies of the nervous system\n Def: Any condition caused by failure of the nervous system to correctly develop during the antenatal period....",
"[8B20] Stroke not known if ischaemic or haemorrhagic\n Def: Fulfills criteria for stroke in acute symptoms of focal brain injury that have lasted 24 hours or more (or led to death before 24 hours), but subtype of stroke (ischemic or haemorrhagic) has not been ...\n --EXCLUDES--> [?] Late effects of stroke not known if ischaemic or haemorrhagic\n Def: Late effects occurring 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episodes....\n --PARENT--> [?] Late effects of cerebrovascular disease\n Def: Effects of cerebrovascular disease 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episo...",
"[8B20] Stroke not known if ischaemic or haemorrhagic\n Def: Fulfills criteria for stroke in acute symptoms of focal brain injury that have lasted 24 hours or more (or led to death before 24 hours), but subtype of stroke (ischemic or haemorrhagic) has not been ...\n --EXCLUDES--> [?] Late effects of stroke not known if ischaemic or haemorrhagic\n Def: Late effects occurring 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episodes....\n --PARENT--> [?] Late effects of cerebrovascular disease\n Def: Effects of cerebrovascular disease 1 month or later after the onset of the disease. Codes for acute stroke should be exclusively used for the acute stroke and immediately related hospitalisation episo..."
] |
1D00.Z
|
Infectious encephalitis, unspecified
|
[
{
"from_icd11": "1D00.Z",
"icd10_code": "G0490",
"icd10_title": "Encephalitis and encephalomyelitis, unspecified"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0491",
"icd10_title": "Myelitis, unspecified"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0430",
"icd10_title": "Acute necrotizing hemorrhagic encephalopathy, unspecified"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0431",
"icd10_title": "Postinfectious acute necrotizing hemorrhagic encephalopathy"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0439",
"icd10_title": "Other acute necrotizing hemorrhagic encephalopathy"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0481",
"icd10_title": "Other encephalitis and encephalomyelitis"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G0489",
"icd10_title": "Other myelitis"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G04",
"icd10_title": "Encephalitis, myelitis and encephalomyelitis"
},
{
"from_icd11": "1D00.Z",
"icd10_code": "G048",
"icd10_title": "Other encephalitis, myelitis and encephalomyelitis"
},
{
"from_icd11": "8B20",
"icd10_code": "I64",
"icd10_title": ""
},
{
"from_icd11": "8B1Z",
"icd10_code": "I67848",
"icd10_title": "Other cerebrovascular vasospasm and vasoconstriction"
},
{
"from_icd11": "8B1Z",
"icd10_code": "I6789",
"icd10_title": "Other cerebrovascular disease"
},
{
"from_icd11": "8B1Z",
"icd10_code": "I6782",
"icd10_title": "Cerebral ischemia"
},
{
"from_icd11": "8B1Z",
"icd10_code": "I6781",
"icd10_title": "Acute cerebrovascular insufficiency"
},
{
"from_icd11": "8B1Z",
"icd10_code": "I67841",
"icd10_title": "Reversible cerebrovascular vasoconstriction syndrome"
}
] |
G0490
|
Encephalitis and encephalomyelitis, unspecified
|
We encountered a 3-month-old girl that was born as the first child to healthy non-consanguineous Dutch parents, by normal vaginal delivery after an uneventful pregnancy conceived by ICSI. She presented in the first weeks of life with irritability and jitteriness, which developed into infantile spasms and severe epileptic activity on multiple electroencephalograms, giving rise to a clinical diagnosis of West syndrome . Despite the use of multiple anti-epileptic drugs, including ACTH and a ketogenic diet, seizures remained intractable and occurred daily. Severe developmental delay was evident without acquisition of any noticeable developmental milestones, causing the need for gastrointestinal tube feeding. Visual tracking was absent, and foveal hypopigmentation, hypermetropia and mild nystagmus were noticed upon ophthalmological investigation. MRI brain imaging showed no gross structural abnormalities or migration disorders at the age of 4 months, but displayed reduced white matter, that further developed into global atrophy with wide sulci and wide pericerebral liquor spaces at the age of 17 months . At that time, she had become progressively microcephalic, with a head circumference of − 2.96 SD at the last investigation at 23 months of age . She showed a number of minor dysmorphisms, including a sloping forehead, elongated head with suture ridging, bitemporal narrowing, a relatively small mouth and large ears . Neurological examination showed brisk, symmetric deep tendon reflexes, more pronounced at the upper limbs. Routine investigations, including metabolic screening in urine, plasma and cerebrospinal fluid were normal. A SNP-array showed a normal female chromosomal profile, with a large, ~ 30 Mb run of homozygosity (ROH) at chromosome 2, and a few smaller ROH regions, adding up to 50 Mb ROH regions in total, pointing to an unrecognized common ancestor of both parents (coefficient of inbreeding 1/64). Subsequent trio WES did not show any disease-causing variants in known DEE genes, but identified a homozygous variant in UGP2 , located in the large ROH region , with no other disease-implicated variants observed in that region. Both parents were heterozygous carriers of the same variant. Via Genematcher and our network of collaborators, we identified 21 additional individuals from 14 unrelated families (of which 10 were consanguineous), harboring the exact same homozygous variant and presenting with an almost identical clinical phenotype of intractable seizures, severe developmental delay, visual disturbance, microcephaly and similar minor dysmorphisms . Ten of these individuals passed away early, with the majority before the age of 3.5 years. In six families, at least seven already deceased siblings had a similar phenotype but could not be investigated. Two families were of Indian descent (both with ancestors from regions currently belonging to Pakistan), living in Canada (family 2) and the USA (family 3), with the remaining families from Oman (family 4, originally from Pakistan), Pakistan (family 5, family 13), Iran (families 6, 7, 8 and 11), UAE (family 9), Saudi Arabia (family 10) and India (family 12). Two additional cases in family 14 from Oman and family 15 from India were identified presenting with intractable seizures and microcephaly, but no detailed medical information could be obtained at this point. Fig. 1 UGP2 homozygous variants in 20 individuals with severe epileptic encephalopathy. a Facial pictures of individual 1 (at 18 and 23 months), individual 5 (at 9 years), individual 6 (at 11 months), individual 9 (at 18 months), individual 10 (at 2 years) and individual 19 (at 13 months). Note the progressive microcephaly with sloping forehead, suture ridging, bitemporal narrowing, high hairline, arched eyebrows, pronounced philtrum, a relatively small mouth and large ears. b Electroencephalogram of individual 1 at the age of 8 months showing a highly disorganized pattern with high-voltage irregular slow waves intermixed with multifocal spikes and polyspikes. c T1-weighted mid-sagittal brain MRI of individual 1 (at 17 months) and individual 4 (at 24 months) illustrating global atrophy and microcephaly but no major structural anomalies. d Sanger sequencing traces of family 1, confirming the chr2:64083454A>G variant in UGP2 in heterozygous and homozygous states in parents and affected individual 1, respectively. e Family pedigrees of ascertained patients. Affected individuals and heterozygous parents are indicated in black and half black, respectively. Affected individuals with confirmed genotype are indicated with an arrow, and numbers. Other not-tested affected siblings presenting with similar phenotypes are indicated with a question mark. Consanguineous parents are indicated with a double connection line. Males are squares, females are circles; unknown sex is indicated with rotated squares; deceased individuals are marked with a line. f Violin plots showing distribution of gene expression (in TPM) amongst male and female samples from the GTEx portal for various brain regions. Outliers are indicated by dots. g Multiple species sequence alignment from the UCSC browser, showing that the ATG start site is highly conserved
| 4.339844
| 0.660645
|
sec[3]/sec[0]/p[0]
|
en
| 0.999997
|
31820119
|
https://doi.org/10.1007/s00401-019-02109-6
|
[
"family",
"individual",
"parents",
"individuals",
"that",
"families",
"large",
"regions",
"homozygous",
"variant"
] |
[
{
"code": "QE70.Z",
"title": "Problems related to primary support group, including family circumstances, unspecified"
},
{
"code": "8C74.1Z",
"title": "Periodic paralysis, unspecified"
},
{
"code": "2B90.Y",
"title": "Other specified malignant neoplasms of colon"
},
{
"code": "EE61",
"title": "Superficial fibromatoses"
},
{
"code": "9B70",
"title": "Inherited retinal dystrophies"
},
{
"code": "LD47.4",
"title": "Autosomal fragile site"
},
{
"code": "LD47.1",
"title": "Chromosome inversion in normal individual"
},
{
"code": "LD47.Y",
"title": "Other specified balanced rearrangements or structural rearrangements"
},
{
"code": "PA80.Z",
"title": "Unintentionally struck by projectile from unspecified firearm"
},
{
"code": "LD47.2",
"title": "Balanced autosomal rearrangement in abnormal individual"
}
] |
=== ICD-11 CODES FOUND ===
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
Also known as: Problems related to primary support group, including family circumstances, unspecified | Problems related to primary support group, including family circumstances | family problem | problem related to primary support group | Problem related to gambling in the family
[8C74.1Z] Periodic paralysis, unspecified
Also known as: Periodic paralysis, unspecified | Periodic paralysis | Westphal disease | periodic myotonia | myoplegic dystrophy
[2B90.Y] Other specified malignant neoplasms of colon
Also known as: Other specified malignant neoplasms of colon | Neuroendocrine neoplasm of colon | Colon endocrine neoplasm | Neuroendocrine carcinoma of colon | NEC - [neuroendocrine carcinoma] of colon
[EE61] Superficial fibromatoses
Also known as: Superficial fibromatoses | Pachydermodactyly | Camptodactyly or streblodactyly | Familial camptodactyly | Sporadic camptodactyly
[9B70] Inherited retinal dystrophies
Also known as: Inherited retinal dystrophies | hereditary retinal dystrophies | Amaurosis - hypertrichosis | Autosomal dominant late-onset retinal degeneration | Bothnia retinal dystrophy
Includes: Leber congenital amaurosis | Stargardt disease | Vitreoretinal dystrophy
[LD47.4] Autosomal fragile site
Definition: Any disease caused by presence of a fragile site on an autosome. These diseases may present as asymptomatic. Confirmation is through observation of a fragile site by genetic testing.
Also known as: Autosomal fragile site | individual with autosomal fragile site | autosomal fragile site syndrome | fragility non-sex chromosome site
[LD47.1] Chromosome inversion in normal individual
Definition: Any disease caused by inversion of genetic material on a chromosome, in an individual demonstrating no abnormalities. Confirmation is through observation of a chromosomal inversion by genetic testing.
Also known as: Chromosome inversion in normal individual
[LD47.Y] Other specified balanced rearrangements or structural rearrangements
Also known as: Other specified balanced rearrangements or structural rearrangements | Extra marker chromosome in normal individual
[PA80.Z] Unintentionally struck by projectile from unspecified firearm
Also known as: Unintentionally struck by projectile from unspecified firearm | Unintentionally struck by projectile from firearm | gunshot wound NOS | shooting | shot NOS
[LD47.2] Balanced autosomal rearrangement in abnormal individual
Definition: Any disease caused by alteration of autosome structure with no net gain or loss of genetic material, in an individual demonstrating abnormalities. Confirmation is through observation of a balanced chromosomal rearrangement by genetic testing.
Also known as: Balanced autosomal rearrangement in abnormal individual
=== GRAPH WALKS ===
--- Walk 1 ---
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
--PARENT--> [QE70] Problems related to primary support group, including family circumstances
--EXCLUDES--> [?] Problems associated with harmful or traumatic events
--- Walk 2 ---
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
--PARENT--> [QE70] Problems related to primary support group, including family circumstances
--EXCLUDES--> [?] Problems associated with harmful or traumatic events
--- Walk 3 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--CHILD--> [8C74.1Y] Other specified periodic paralysis
--- Walk 4 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--CHILD--> [8C74.1Y] Other specified periodic paralysis
--- Walk 5 ---
[2B90.Y] Other specified malignant neoplasms of colon
--PARENT--> [2B90] Malignant neoplasms of colon
Def: Primary malignant neoplasms arising in the colon....
--EXCLUDES--> [?] Malignant neoplasms of appendix
Def: A primary malignant neoplasm that affects the appendix....
--- Walk 6 ---
[2B90.Y] Other specified malignant neoplasms of colon
--PARENT--> [2B90] Malignant neoplasms of colon
Def: Primary malignant neoplasms arising in the colon....
--EXCLUDES--> [?] Malignant neoplasms of appendix
Def: A primary malignant neoplasm that affects the appendix....
|
[
"[QE70.Z] Problems related to primary support group, including family circumstances, unspecified\n --PARENT--> [QE70] Problems related to primary support group, including family circumstances\n --EXCLUDES--> [?] Problems associated with harmful or traumatic events",
"[QE70.Z] Problems related to primary support group, including family circumstances, unspecified\n --PARENT--> [QE70] Problems related to primary support group, including family circumstances\n --EXCLUDES--> [?] Problems associated with harmful or traumatic events",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --CHILD--> [8C74.1Y] Other specified periodic paralysis",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --CHILD--> [8C74.1Y] Other specified periodic paralysis",
"[2B90.Y] Other specified malignant neoplasms of colon\n --PARENT--> [2B90] Malignant neoplasms of colon\n Def: Primary malignant neoplasms arising in the colon....\n --EXCLUDES--> [?] Malignant neoplasms of appendix\n Def: A primary malignant neoplasm that affects the appendix....",
"[2B90.Y] Other specified malignant neoplasms of colon\n --PARENT--> [2B90] Malignant neoplasms of colon\n Def: Primary malignant neoplasms arising in the colon....\n --EXCLUDES--> [?] Malignant neoplasms of appendix\n Def: A primary malignant neoplasm that affects the appendix...."
] |
QE70.Z
|
Problems related to primary support group, including family circumstances, unspecified
|
[
{
"from_icd11": "QE70.Z",
"icd10_code": "Z6379",
"icd10_title": "Other stressful life events affecting family and household"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z6372",
"icd10_title": "Alcoholism and drug addiction in family"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z638",
"icd10_title": "Other specified problems related to primary support group"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z639",
"icd10_title": "Problem related to primary support group, unspecified"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z637",
"icd10_title": "Other stressful life events affecting family and household"
},
{
"from_icd11": "8C74.1Z",
"icd10_code": "G723",
"icd10_title": "Periodic paralysis"
},
{
"from_icd11": "EE61",
"icd10_code": "F54",
"icd10_title": "Psychological and behavioral factors associated with disorders or diseases classified elsewhere"
},
{
"from_icd11": "9B70",
"icd10_code": "H3552",
"icd10_title": "Pigmentary retinal dystrophy"
},
{
"from_icd11": "9B70",
"icd10_code": "H3550",
"icd10_title": "Unspecified hereditary retinal dystrophy"
},
{
"from_icd11": "9B70",
"icd10_code": "H3553",
"icd10_title": "Other dystrophies primarily involving the sensory retina"
},
{
"from_icd11": "9B70",
"icd10_code": "H3554",
"icd10_title": "Dystrophies primarily involving the retinal pigment epithelium"
},
{
"from_icd11": "9B70",
"icd10_code": "H355",
"icd10_title": "Hereditary retinal dystrophy"
},
{
"from_icd11": "LD47.4",
"icd10_code": "Q955",
"icd10_title": "Individual with autosomal fragile site"
},
{
"from_icd11": "LD47.1",
"icd10_code": "Q951",
"icd10_title": "Chromosome inversion in normal individual"
},
{
"from_icd11": "LD47.2",
"icd10_code": "Q952",
"icd10_title": "Balanced autosomal rearrangement in abnormal individual"
}
] |
Z6379
|
Other stressful life events affecting family and household
|
This case study demonstrates spontaneous recovery from EVD and associated malarial and urinary tract coinfections in a pregnant woman infected during the first trimester of pregnancy and an uncomplicated fetal survival. Limitations of our study are mostly due to the unavailability of adequate laboratory and diagnostic equipment (for biochemistry results, hemograms, tests for inflammatory markers, and pelvic ultrasound) at the point of care during her illness, as well as absence of EBOV sequencing in the mother and virology and serology follow-up in the newborn. The missing clinical and diagnostic resources would have enabled more thorough surveillance and clinical case management. In utero, fetal susceptibility to pathogens corresponds with gestational age, and early pregnancy is the most vulnerable period. The synthesis of protective fetal antibodies (IgM and IgG) starts around the 20th week of gestation, and maternal antibodies (IgG) start crossing the placenta barrier from 13th weeks of gestational . In addition, the synthesis of maternal anti-EVD immunoglobulins begins only after the sixth day symptom onset . As their passage is impossible for fetal protection before 13 weeks, and our patient was infected at 5 weeks gestation, this child may not have received maternal IgG protection against EVD in utero during illness. Considering these factors, the immunological environment of maternal EVD in the first trimester of the pregnancy could have created conditions for spontaneous abortion; but this pregnancy persisted. High Ebola viral load is described in both the placenta and amniotic fluid in most cases of maternal EVD, which can cause FDIU even after maternal recovery . In this case study, fetal vulnerability was compounded further by maternal malarial infection, absence of monoclonal treatment, and the potential side effects of vaccination against EBOV as listed previously, which our patient received in the third week of her pregnancy. Moderate vaginal bleeding observed for three days upon her admission to the ETU could have been due to partial placental abruption. Without ultrasound equipment, we could not confirm this, although clinically partial abruption is the only plausible diagnosis. If further placental abruption occurred, consequences would have included not only destruction of the haematoplacental barrier, causing mixing of maternal and fetal blood and increased risk of a direct fetal EVD in utero, but also an increased risk of spontaneous abortion. Despite cumulative threats to both mother and fetus, all of which elevated the risk of spontaneous abortion, this pregnancy developed well resulting in a healthy newborn. Since most pregnancies that survive maternal EVD have generally a negative outcome , the successful development and birth of an Ebola-free infant after spontaneous maternal recovery may challenge the theory of systematic vertical transmission of Ebola during pregnancy. A recent case report strengthens this hypothesis as it described the survival of a premature newborn without Ebola born to a mother in the acute phase of EVD . In addition, we thought that if our patient had benefited the monoclonal therapy, she would early negativize her viral load. Therefore, during Ebola outbreak, availability of stocks of monoclonal therapy is essential in ETUs. In this case, the favorable clinical progress of the mother raises the question of whether EBOV strains of different virulence could have circulated during the 11th epidemic in DRC. Less virulent strains could have elicited maternal immunity without causing severe morbidity or mortality. It is also possible that the virus gradually lost its virulence through multiple passages in humans or due to the recurring nature of Ebola epidemics in this area causing host adaptation to the virus. A study carried out on 130 cases recorded in the 11th outbreak generated 87 genomes with two variants including Mbandaka in 84 (97%) cases and the Tumba variant in four cases. The Tumba variant exhibited a reduced substitution rate, suggesting transmission from a previous EVD survivor of ninth EVD outbreak in the same province . However, Zaire strain was the sole strain in this outbreak, and severe EVD cases were still observed throughout this outbreak. In addition, the CFR during this outbreak was 42% which prompts us to look for additional causes, beyond the low virulence of the virus . Furthermore, with such a trend of viral load, there is a possibility that detected particles of RNA by RT-PCR may no longer be able to fully replicate and that this may have had a positive impact on the infant status even though the mother displayed recognizable Ct values. We hypothesize that spontaneous maternal recovery from an EVD and associated fetal survival in this case study could have been linked to the absence of severe maternal comorbidities during the acute phase of the infection apart from malaria infection, vaccine-induced maternal immunity , and the supportive treatment our patient received upon diagnosis at home and during her admission in the ETU. Considering all the risk factors associated with this pregnancy, its development and subsequent neonatal survival are exceptional.
| 4.332031
| 0.76416
|
sec[2]/p[0]
|
en
| 0.999997
|
PMC11928211
|
https://doi.org/10.1155/crdi/2987569
|
[
"this",
"maternal",
"pregnancy",
"fetal",
"spontaneous",
"ebola",
"that",
"outbreak",
"mother",
"cases"
] |
[
{
"code": "4A01.03",
"title": "Transient hypogammaglobulinaemia of infancy"
},
{
"code": "6E20",
"title": "Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms"
},
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "LD2F.Y",
"title": "Other specified syndromes with multiple structural anomalies, without predominant body system involvement"
},
{
"code": "JA82.6",
"title": "Maternal care for compound presentation"
},
{
"code": "JA8A.0",
"title": "Placental transfusion syndromes"
},
{
"code": "JA80.Z",
"title": "Maternal care related to unspecified multiple gestation"
},
{
"code": "JA01.1",
"title": "Tubal pregnancy"
},
{
"code": "QA40",
"title": "Pregnancy examination or test"
},
{
"code": "JA61.Y",
"title": "Other specified venous complications in pregnancy"
}
] |
=== ICD-11 CODES FOUND ===
[4A01.03] Transient hypogammaglobulinaemia of infancy
Also known as: Transient hypogammaglobulinaemia of infancy | immunoglobulin maturational delay | THI - [transient hypogammaglobulinaemia of infancy]
[6E20] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms
Definition: A syndrome associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involves significant mental and behavioural features, most commonly depressive symptoms. The syndrome does not include delusions, hallucinations, or other psychotic symptoms. If the symptoms meet the diagnostic requirements for a specific mental disorder, that diagnosis should also be assigned. This designation should not be used to describe mild and transient depressive symptoms that do
Also known as: Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms | mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic features | Postpartum depression NOS | postnatal depression NOS | puerperal depression NOS
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[LD2F.Y] Other specified syndromes with multiple structural anomalies, without predominant body system involvement
Also known as: Other specified syndromes with multiple structural anomalies, without predominant body system involvement | Syndromes with multiple structural anomalies of environmental origin | congenital malformation syndromes due to known exogenous causes, not elsewhere classified | Infectious embryofetopathies | Embryofetopathies due to specified maternal conditions
[JA82.6] Maternal care for compound presentation
Also known as: Maternal care for compound presentation | compound presentation of fetus
[JA8A.0] Placental transfusion syndromes
Also known as: Placental transfusion syndromes | placental transfusion | placenta transfusion syndrome | Twin to twin transfusion syndrome | Feto-fetal transfusion syndrome
[JA80.Z] Maternal care related to unspecified multiple gestation
Also known as: Maternal care related to unspecified multiple gestation | Maternal care related to multiple gestation | multiple gestation, unspecified, unspecified trimester | multiple pregnancy | Multiple pregnancy NOS
[JA01.1] Tubal pregnancy
Definition: A condition characterised by implantation of the embryo within the fallopian tube (ampullary, isthmus, interstitium) during pregnancy.
Also known as: Tubal pregnancy | Fallopian pregnancy | fallopian tube pregnancy | Tubal abortion | Rupture of fallopian tube due to pregnancy
Includes: Fallopian pregnancy | Tubal abortion
[QA40] Pregnancy examination or test
Also known as: Pregnancy examination or test | pregnancy examination | pregnancy test | Pregnancy examination or test, pregnancy not confirmed | pregnancy not yet confirmed
[JA61.Y] Other specified venous complications in pregnancy
Also known as: Other specified venous complications in pregnancy | Venous thrombosis in pregnancy | antepartum thrombosis NOS | Gestational thrombosis NOS | thrombosis in pregnancy NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--CHILD--> [4A01.01] Immunodeficiencies with severe reduction in at least two serum immunoglobulin isotypes with normal or low numbers of B cells
Def: This refers to a nonfamilial type of primary immune deficiency disease characterised by a reduction in at least two serum immunoglobulin isotypes. Circulating B cells may be normal or low....
--- Walk 2 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--PARENT--> [4A01] Primary immunodeficiencies due to disorders of adaptive immunity
--- Walk 3 ---
[6E20] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms
Def: A syndrome associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involves significant mental and behavioural features, most commonly depressive symptoms. Th...
--PARENT--> [?] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium
Def: Syndromes associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involve significant mental and behavioural features. If the symptoms meet the diagnostic req...
--CHILD--> [6E2Z] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, unspecified
--- Walk 4 ---
[6E20] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms
Def: A syndrome associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involves significant mental and behavioural features, most commonly depressive symptoms. Th...
--PARENT--> [?] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium
Def: Syndromes associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involve significant mental and behavioural features. If the symptoms meet the diagnostic req...
--RELATED_TO--> [?] Psychological disorder related to obstetric fistula
Def: Any condition characterised by the presence of a psychological disorder related to an abnormal connection or passageway between the vagina and the rectum or bladder after severe or failed childbirth....
--- Walk 5 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia
--- Walk 6 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--EXCLUDES--> [?] Placental transfusion syndromes
|
[
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --CHILD--> [4A01.01] Immunodeficiencies with severe reduction in at least two serum immunoglobulin isotypes with normal or low numbers of B cells\n Def: This refers to a nonfamilial type of primary immune deficiency disease characterised by a reduction in at least two serum immunoglobulin isotypes. Circulating B cells may be normal or low....",
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --PARENT--> [4A01] Primary immunodeficiencies due to disorders of adaptive immunity",
"[6E20] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms\n Def: A syndrome associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involves significant mental and behavioural features, most commonly depressive symptoms. Th...\n --PARENT--> [?] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium\n Def: Syndromes associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involve significant mental and behavioural features. If the symptoms meet the diagnostic req...\n --CHILD--> [6E2Z] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, unspecified",
"[6E20] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptoms\n Def: A syndrome associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involves significant mental and behavioural features, most commonly depressive symptoms. Th...\n --PARENT--> [?] Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium\n Def: Syndromes associated with pregnancy or the puerperium (commencing within about 6 weeks after delivery) that involve significant mental and behavioural features. If the symptoms meet the diagnostic req...\n --RELATED_TO--> [?] Psychological disorder related to obstetric fistula\n Def: Any condition characterised by the presence of a psychological disorder related to an abnormal connection or passageway between the vagina and the rectum or bladder after severe or failed childbirth....",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --EXCLUDES--> [?] Placental transfusion syndromes"
] |
4A01.03
|
Transient hypogammaglobulinaemia of infancy
|
[
{
"from_icd11": "4A01.03",
"icd10_code": "D807",
"icd10_title": "Transient hypogammaglobulinemia of infancy"
},
{
"from_icd11": "6E20",
"icd10_code": "F53",
"icd10_title": "Mental and behavioral disorders associated with the puerperium, not elsewhere classified"
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "LD2F.Y",
"icd10_code": "Q8789 ",
"icd10_title": ""
},
{
"from_icd11": "JA82.6",
"icd10_code": "O326XX0",
"icd10_title": "Maternal care for compound presentation, not applicable or unspecified"
},
{
"from_icd11": "JA82.6",
"icd10_code": "O326",
"icd10_title": "Maternal care for compound presentation"
},
{
"from_icd11": "JA8A.0",
"icd10_code": "O43022",
"icd10_title": "Fetus-to-fetus placental transfusion syndrome, second trimester"
},
{
"from_icd11": "JA8A.0",
"icd10_code": "O430",
"icd10_title": "Placental transfusion syndromes"
},
{
"from_icd11": "JA80.Z",
"icd10_code": "O30",
"icd10_title": "Multiple gestation"
},
{
"from_icd11": "JA80.Z",
"icd10_code": "O308",
"icd10_title": "Other specified multiple gestation"
},
{
"from_icd11": "JA80.Z",
"icd10_code": "O309",
"icd10_title": "Multiple gestation, unspecified"
},
{
"from_icd11": "JA01.1",
"icd10_code": "O00102",
"icd10_title": "Left tubal pregnancy without intrauterine pregnancy"
}
] |
D807
|
Transient hypogammaglobulinemia of infancy
|
A male infant born at 38 weeks of gestation was diagnosed with tricuspid atresia and hypoplastic right ventricle by a fetal ultrasound scan. Transthoracic echocardiography revealed tricuspid atresia, ventricular septal defect (VSD), pulmonary stenosis, patent ductus arteriosus (PDA), and patent foramen ovale immediately after birth. E-type prostaglandin was prescribed to prevent spontaneous closure of PDA. However, this closure could not be prevented and his oxygen saturation level dropped to 75%. He then underwent BTS and main pulmonary artery division for first palliation at the age of 2 months. A midesophageal four-chamber view using transesophageal echocardiography (TEE) revealed tricuspid atresia, a hypoplastic right ventricle, and VSD . A midesophageal right ventricle inflow–outflow view using color Doppler imaging demonstrated pulmonary stenosis that caused dissipative flow in the main pulmonary artery before the procedure . After the procedure, a midesophageal ascending aortic short-axis view using color Doppler imaging demonstrated an antegrade flow from the completely severed main pulmonary artery to both the right and left pulmonary arteries due to BTS, which connected the brachiocephalic artery to the main pulmonary artery . The intraoperative clinical course was uneventful. Pre- and postprocedural hemodynamic parameters were as shown in Table 1 . The intraventricular blood flow, energy loss, and kinetic energy of the left ventricular outflow tract were assessed using a vector flow mapping software (Hitachi, Tokyo, Japan) in the midesophageal long-axis view by TEE during the surgery . Intraventricular energy loss and kinetic energy of the left ventricular outflow tract were higher in the postoperative phase than in the preoperative phase . The mean energy loss and kinetic energy increased from 29.4 mW/m to 41.9 mW/m and 35.6 mW/m to 83.8 mW/m, respectively. The patient’s pulmonary blood flow progressively worsened with age; therefore, he underwent BCPS and BTS division for second palliation at the age of 11 months. After the procedure, a midesophageal ascending aortic short-axis view by intraoperative TEE revealed a retrograde flow from the right pulmonary artery to the left pulmonary artery due to BCPS, which connected the superior vena cava with the right pulmonary artery . Pre- and postprocedural hemodynamic parameters were as shown in Table 1 . Vector flow mapping analysis was performed again for this second palliation . Intraventricular energy loss and kinetic energy of the left ventricular outflow tract were lower in the postoperative phase than in the preoperative phase . The mean energy loss and kinetic energy decreased from 38.3 mW/m to 30.7 mW/m and 127.4 mW/m to 62.0 mW/m, respectively. Fig. 1 Intraoperative transesophageal echocardiographic images. a Midesophageal four-chamber view demonstrating tricuspid atresia, a hypoplastic right ventricle, and VSD. b Midesophageal right ventricle inflow–outflow view using color Doppler imaging demonstrating pulmonary stenosis that caused a dissipative flow in the main pulmonary artery before BTS. c Midesophageal ascending aortic short-axis view using color Doppler imaging demonstrating an antegrade flow from the completely severed main pulmonary artery to both the right and left pulmonary arteries due to BTS, which connected the brachiocepharic artery to the main pulmonary artery. d , Midesophageal ascending aortic short-axis view demonstrating the retrograde flow from the right pulmonary artery to the left pulmonary artery due to the BCPS, which connected the superior vena cava to the right pulmonary artery Table 1 Intraoperative hemodynamic parameters pre BTS post BTS pre BCPS post BCPS HR (bpm) 137 156 131 125 BP (mmHg) 65/43 74/37 75/42 72/45 SpO 2 (%) 84 88 82 94 FiO 2 0.73 0.47 0.33 1.0 CVP (mmHg) 11 15 13 16 BTS Blalock-Taussig shunt, BCPS bidirectional cavopulmonary shunt, HR heart rate, BP blood pressure, CVP central venous pressure Fig. 2 Vector flow mapping and energy loss images in midesophageal long-axis view. Brightness indicates energy loss. A , Vector flow mapping image before BTS. A’ , Energy loss image before BTS. B , Vector flow mapping image after BTS. B′ , Energy loss image after BTS. The large bright area indicates increased energy loss compared to Fig. A’ due to the hyperdynamic state. C , Vector flow mapping image before BCPS. Volume loads decrease compared to Fig. B due to the worsened pulmonary blood flow. C′ , Energy loss image before BCPS. D , Vector flow mapping image after BCPS. D’ , Energy loss image after BCPS. The small bright area indicates decreased energy loss compared to Fig. C′ due to the hypodynamic state Fig. 3 Energy loss and kinetic energy graph during one cardiac cycle. Left upper panel , Energy loss graph before and after BTS. Energy loss increased after BTS. Right upper panel , Kinetic energy graph of the left ventricular outflow tract before and after BTS. Kinetic energy increased after BTS. Left lower panel , Energy loss graph before and after BCPS. Energy loss decreased after BCPS. Right lower panel , Kinetic energy graph of the left ventricular outflow tract before and after BCPS. Kinetic energy decreased after BCPS
| 4.167969
| 0.943359
|
sec[1]/p[0]
|
en
| 0.999997
|
29241451
|
https://doi.org/10.1186/s12947-017-0118-3
|
[
"energy",
"pulmonary",
"loss",
"flow",
"artery",
"bcps",
"midesophageal",
"view",
"kinetic",
"main"
] |
[
{
"code": "MB22.4",
"title": "Increased energy"
},
{
"code": "MG22",
"title": "Fatigue"
},
{
"code": "5C53.Z",
"title": "Inborn errors of energy metabolism, unspecified"
},
{
"code": "5C53.Y",
"title": "Other specified inborn errors of energy metabolism"
},
{
"code": "5B7Z",
"title": "Unspecified undernutrition"
},
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "LA75.1",
"title": "Agenesis of lung"
},
{
"code": "CA40.Z",
"title": "Pneumonia, organism unspecified"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "NB32.3Y",
"title": "Other injury of lung"
}
] |
=== ICD-11 CODES FOUND ===
[MB22.4] Increased energy
Definition: Increased physical or mental resources for activity, typically characterised by increased capacity for work and greater efficiency in responding to stimuli.
Also known as: Increased energy
[MG22] Fatigue
Definition: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and reduced efficiency in responding to stimuli. Fatigue is normal following a period of exertion, mental or physical, but sometimes may occur in the absence of such exertion as a symptom of health conditions.
Also known as: Fatigue | decreased energy | worn out | Lethargy | lethargic
Includes: General physical deterioration | Lethargy
Excludes: Combat fatigue | Exhaustion due to exposure | heat exhaustion
[5C53.Z] Inborn errors of energy metabolism, unspecified
Also known as: Inborn errors of energy metabolism, unspecified | Inborn errors of energy metabolism | Disorders of energy metabolism | congenital disorders of energy metabolism | inherited disorders of energy metabolism
[5C53.Y] Other specified inborn errors of energy metabolism
Also known as: Other specified inborn errors of energy metabolism | Unspecified mitochondrial disorders | mitochondrial disease NOS | Leigh syndrome with no known genetic or respiratory chain deficiency | Cataract - cardiomyopathy
[5B7Z] Unspecified undernutrition
Also known as: Unspecified undernutrition | Malnutrition NOS | nutritional deficiency NOS | nutritional depletion NOS | severe malnutrition NOS
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[LA75.1] Agenesis of lung
Definition: This refers to the absence or rudimentary residua of an undeveloped lung.
Also known as: Agenesis of lung | Pulmonary agenesis | absence of lung | aplasia of lung | apulmonism
[CA40.Z] Pneumonia, organism unspecified
Also known as: Pneumonia, organism unspecified | Pneumonia | infectious pneumonia | PN - [pneumonia] | lobar pneumonia NOS
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[NB32.3Y] Other injury of lung
Also known as: Other injury of lung | Haematoma of lung | Traumatic hydropneumothorax | Acute traumatic lung congestion | Rupture of lung
=== GRAPH WALKS ===
--- Walk 1 ---
[MB22.4] Increased energy
Def: Increased physical or mental resources for activity, typically characterised by increased capacity for work and greater efficiency in responding to stimuli....
--PARENT--> [MB22] Symptoms or signs involving motivation or energy
Def: Symptoms and signs involving motivation (the process that initiates, guides, and maintains goal-oriented behaviours) or energy (the strength and vitality required for sustained physical or mental acti...
--RELATED_TO--> [?] Fatigue
Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...
--- Walk 2 ---
[MB22.4] Increased energy
Def: Increased physical or mental resources for activity, typically characterised by increased capacity for work and greater efficiency in responding to stimuli....
--PARENT--> [MB22] Symptoms or signs involving motivation or energy
Def: Symptoms and signs involving motivation (the process that initiates, guides, and maintains goal-oriented behaviours) or energy (the strength and vitality required for sustained physical or mental acti...
--RELATED_TO--> [?] Fatigue
Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...
--- Walk 3 ---
[MG22] Fatigue
Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...
--EXCLUDES--> [?] Acute stress reaction
Def: Acute stress reaction refers to the development of transient emotional, somatic, cognitive, or behavioural symptoms as a result of exposure to an event or situation (either short- or long-lasting) of ...
--CHILD--> [?] Exhaustion delirium
--- Walk 4 ---
[MG22] Fatigue
Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...
--EXCLUDES--> [?] Effects of heat
Def: Adverse effects resulting from a failure to maintain normal body core temperature on exposure to excessive heat. Vigorous exercise, insulation by clothing (e.g. protective clothing) or an inability to...
--CHILD--> [?] Heat syncope
Def: Fainting attributable to exposure to heat...
--- Walk 5 ---
[5C53.Z] Inborn errors of energy metabolism, unspecified
--PARENT--> [5C53] Inborn errors of energy metabolism
--CHILD--> [5C53.1] Disorders of the citric acid cycle
--- Walk 6 ---
[5C53.Z] Inborn errors of energy metabolism, unspecified
--PARENT--> [5C53] Inborn errors of energy metabolism
--CHILD--> [5C53.0] Disorders of pyruvate metabolism
|
[
"[MB22.4] Increased energy\n Def: Increased physical or mental resources for activity, typically characterised by increased capacity for work and greater efficiency in responding to stimuli....\n --PARENT--> [MB22] Symptoms or signs involving motivation or energy\n Def: Symptoms and signs involving motivation (the process that initiates, guides, and maintains goal-oriented behaviours) or energy (the strength and vitality required for sustained physical or mental acti...\n --RELATED_TO--> [?] Fatigue\n Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...",
"[MB22.4] Increased energy\n Def: Increased physical or mental resources for activity, typically characterised by increased capacity for work and greater efficiency in responding to stimuli....\n --PARENT--> [MB22] Symptoms or signs involving motivation or energy\n Def: Symptoms and signs involving motivation (the process that initiates, guides, and maintains goal-oriented behaviours) or energy (the strength and vitality required for sustained physical or mental acti...\n --RELATED_TO--> [?] Fatigue\n Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...",
"[MG22] Fatigue\n Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...\n --EXCLUDES--> [?] Acute stress reaction\n Def: Acute stress reaction refers to the development of transient emotional, somatic, cognitive, or behavioural symptoms as a result of exposure to an event or situation (either short- or long-lasting) of ...\n --CHILD--> [?] Exhaustion delirium",
"[MG22] Fatigue\n Def: A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and redu...\n --EXCLUDES--> [?] Effects of heat\n Def: Adverse effects resulting from a failure to maintain normal body core temperature on exposure to excessive heat. Vigorous exercise, insulation by clothing (e.g. protective clothing) or an inability to...\n --CHILD--> [?] Heat syncope\n Def: Fainting attributable to exposure to heat...",
"[5C53.Z] Inborn errors of energy metabolism, unspecified\n --PARENT--> [5C53] Inborn errors of energy metabolism\n --CHILD--> [5C53.1] Disorders of the citric acid cycle",
"[5C53.Z] Inborn errors of energy metabolism, unspecified\n --PARENT--> [5C53] Inborn errors of energy metabolism\n --CHILD--> [5C53.0] Disorders of pyruvate metabolism"
] |
MB22.4
|
Increased energy
|
[
{
"from_icd11": "MB22.4",
"icd10_code": "R4689",
"icd10_title": "Other symptoms and signs involving appearance and behavior"
},
{
"from_icd11": "MB22.4",
"icd10_code": "R4681",
"icd10_title": "Obsessive-compulsive behavior"
},
{
"from_icd11": "MB22.4",
"icd10_code": "R468",
"icd10_title": "Other symptoms and signs involving appearance and behavior"
},
{
"from_icd11": "MG22",
"icd10_code": "R5382",
"icd10_title": "Chronic fatigue, unspecified"
},
{
"from_icd11": "MG22",
"icd10_code": "R530",
"icd10_title": "Neoplastic (malignant) related fatigue"
},
{
"from_icd11": "MG22",
"icd10_code": "R532",
"icd10_title": "Functional quadriplegia"
},
{
"from_icd11": "MG22",
"icd10_code": "R531",
"icd10_title": "Weakness"
},
{
"from_icd11": "MG22",
"icd10_code": "R5383",
"icd10_title": "Other fatigue"
},
{
"from_icd11": "MG22",
"icd10_code": "R53",
"icd10_title": "Malaise and fatigue"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E43",
"icd10_title": "Unspecified severe protein-calorie malnutrition"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E538",
"icd10_title": "Deficiency of other specified B group vitamins"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E569",
"icd10_title": "Vitamin deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E638",
"icd10_title": "Other specified nutritional deficiencies"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E639",
"icd10_title": "Nutritional deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E41",
"icd10_title": "Nutritional marasmus"
}
] |
R4689
|
Other symptoms and signs involving appearance and behavior
|
We present the case of a 54-year-old male person living with HIV (PLWHIV) (HIV-1, CDC stage B3) who was involved in a motor vehicle accident (MVA) in Nigeria. HIV infection had been diagnosed in 1997, 26 years prior to the diagnosis of mucormycosis. From the initial diagnosis, the patient was on continuous antiretroviral therapy, currently consisting of daily Emtricitabine (50 mg), Tenofovir alafenamide (200 mg), and Bictegravir (25 mg). At the time of mucormycosis diagnosis, the patient’s HIV-1 RNA was suppressed to <20 copies/mL, and the CD4+ lymphocyte count was 528 cells/μL. The patient was initially treated in a local hospital for four days, where only contused lacerations on the right side of the face were treated, and no further assessment was undertaken. The patient then flew commercially to Switzerland for further treatment at the University Hospital of Zurich. Upon admission, the patient fulfilled the criteria for polytrauma, presenting multiple severe injuries. The cranial assessment revealed a concussion accompanied by a right monocular hematoma. Thoracic trauma included a multifragmentary, dislocated clavicular shaft fracture; a multifragmentary, dislocated scapular fracture; and severely dislocated fractures of the first to ninth ribs, resulting in a flail chest. These symptoms were further complicated by pneumothorax and marked pneumomediastinum. Spinal injuries comprised slightly displaced fractures of the transverse processes of the first and second lumbar vertebrae. Additionally, a tibial head fracture was identified and managed via osteosynthesis. On arrival, no evidence of mucormycosis was noted. On day 12 of hospitalization, the patient developed focal signs of infection and pus, initially interpreted as a bacterial infection over the right eye . Initially, neurological involvement of the infection could not be ruled out, as MRI was contraindicated due to possible residual metal from the accident in the skull and the onset of delirium, coupled with the patient’s refusal of debridement due to potential morbidity on day 13 of hospitalization. Therefore, only broad-spectrum antibiotic therapy with Piperacillin/tazobactam 4.5 g every 8 h could be initiated. After obtaining the patient’s consent, debridement of the infected area was performed, with the subsequent submission of the debrided tissue for culture and histological analysis, which presented Staphylococcus epidermidis. Despite broad-spectrum antibiotics, surgical debridement by a multidisciplinary team, and vigilant wound care, the patient’s condition deteriorated. Forty days after the accident and 28 days after the onset of symptoms, A. elegans was identified by sequencing 18S rRNA from soft tissue. Homology with the GenBank 18S rRNA sequence showed 0 mismatches and 100% identity. Primers for identification were used according to the broad-coverage fungal quantitative real-time PCR assay FungiQuant . A microbiological report is attached to this study. The most likely route of transmission of A. elegans was the contamination of wounds at the accident site. However, infection from contaminated surgical sutures or postoperative dressings during the initial treatment in Nigeria could not be excluded. Immediately after the identification of A. elegans as the cause of mucormycosis, treatment with liposomal Amphotericin B (Ambisome) at 10 mg/kg body weight i.v. every 24 h, and Isavuconazole at 200 mg every 8 h was initiated. In addition, local irrigation of the wound with AMB and aggressive surgical debridement were continued. As emphasized by Cornely et al. , early surgical debridement remains the cornerstone of successful management in cutaneous mucormycosis . Due to the rhino-orbito-cerebral nature of the infection, the patient underwent right orbital exenteration. Neurological involvement of the infection was discovered after an MRI could be performed, and multiple cerebral abscess evacuations were subsequently carried out by neurosurgeons. The hospitalization was complicated by pneumonia, pleocytosis, cerebral venous sinus thrombosis (treated from day 20 of hospitalization with low-molecular-weight heparin), acute myocardial injury, and delirium. The disease was controlled by multiple debridements performed by different specialties, orbital enucleation, and liposomal AMB treatment. The patient was initially discharged for rehabilitation 116 days after admission following successful infection control. After rehabilitation, the patient was readmitted twice for mucormycosis recurrence and once for pneumonitis. Antifungal and antibiotic therapy were restarted, and further debridements were performed. In total, the patient spent 259 days in hospital or rehabilitation. Unfortunately, the patient died due to sepsis of an unknown origin, leading to rapid deterioration with respiratory insufficiency, lactate increase, and hypoglycemia. It became clear that stabilization would not be possible without intensive care for multiple organ failure. After interdisciplinary discussion and conversations with the patient’s family, treatment was switched to the best supportive care due to exhausted infectious and surgical treatment options and the overall poor prognosis.
| 3.964844
| 0.979492
|
sec[1]/p[0]
|
en
| 0.999997
|
40422702
|
https://doi.org/10.3390/jof11050368
|
[
"infection",
"mucormycosis",
"debridement",
"accident",
"initially",
"multiple",
"hospitalization",
"treated",
"dislocated",
"fracture"
] |
[
{
"code": "1H0Z",
"title": "Infection, unspecified"
},
{
"code": "1G40",
"title": "Sepsis without septic shock"
},
{
"code": "FA10.Z",
"title": "Direct infections of joint, unspecified"
},
{
"code": "1D9Z",
"title": "Unspecified viral infection of unspecified site"
},
{
"code": "1A40.Z",
"title": "Infectious gastroenteritis or colitis without specification of infectious agent"
},
{
"code": "1F2C",
"title": "Mucormycosis"
},
{
"code": "BA41.Z",
"title": "Acute myocardial infarction, unspecified"
},
{
"code": "PA0Z",
"title": "Unintentional land transport traffic event injuring a user of unspecified land transport"
},
{
"code": "PA05",
"title": "Unintentional land transport traffic event injuring an occupant of a bus or coach"
},
{
"code": "PA20",
"title": "Unintentional land transport event unknown whether traffic or nontraffic injuring a pedestrian"
}
] |
=== ICD-11 CODES FOUND ===
[1H0Z] Infection, unspecified
Also known as: Infection, unspecified | infection NOS | infectious disease NOS | infection unknown | infection process NOS
[1G40] Sepsis without septic shock
Definition: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Also known as: Sepsis without septic shock | sepsis without septic shock with known organism | Sepsis-associated hypotension | Unspecified sepsis | general septic intoxication
Excludes: Septicaemia | Sepsis of fetus or newborn
[FA10.Z] Direct infections of joint, unspecified
Also known as: Direct infections of joint, unspecified | Direct infections of joint | septic arthritis | pyogenic arthritis | arthritis due to infection
[1D9Z] Unspecified viral infection of unspecified site
Also known as: Unspecified viral infection of unspecified site | viral infection NOS | viral disorder NOS | disease caused by virus | unspecified viremia
[1A40.Z] Infectious gastroenteritis or colitis without specification of infectious agent
Also known as: Infectious gastroenteritis or colitis without specification of infectious agent | Gastroenteritis or colitis without specification of infectious agent | diarrhoea and gastroenteritis of presumed infectious origin | diarrhoeal enteritis | GE - [gastroenteritis]
[1F2C] Mucormycosis
Definition: A disease caused by an infection with the fungi from the order Mucorales. This disease presents with symptoms depending on the site of the infection. Transmission is by direct contact with infected soil or decaying matter. Confirmation is by identification of fungi from the order Mucorales from a tissue sample.
Also known as: Mucormycosis | Absidia infection | Absidia mucoromycosis | Cunninghamella infection | Cunninghamella mucoromycosis
[BA41.Z] Acute myocardial infarction, unspecified
Also known as: Acute myocardial infarction, unspecified | Acute myocardial infarction | cardiac attack | heart attack | acute cardiac infarction
[PA0Z] Unintentional land transport traffic event injuring a user of unspecified land transport
Also known as: Unintentional land transport traffic event injuring a user of unspecified land transport | unintentional land transport injury event in road crash | unintentional land transport injury event on road | unintentional traffic accident | car accident NOS
[PA05] Unintentional land transport traffic event injuring an occupant of a bus or coach
Also known as: Unintentional land transport traffic event injuring an occupant of a bus or coach | Bus occupant injured in transport accident | Bus collision NOS, traffic | Bus accident NOS | Bus occupant injured in collision with pedestrian or animal
[PA20] Unintentional land transport event unknown whether traffic or nontraffic injuring a pedestrian
Also known as: Unintentional land transport event unknown whether traffic or nontraffic injuring a pedestrian | unintentional crash injuring a pedestrian, unknown whether on road | pedestrian accident NOS | pedestrian struck by motor vehicle | pedestrian struck by vehicle
=== GRAPH WALKS ===
--- Walk 1 ---
[1H0Z] Infection, unspecified
--PARENT--> [01] Certain infectious or parasitic diseases
Def: This chapter includes certain conditions caused by pathogenic organisms or microorganisms, such as bacteria, viruses, parasites or fungi....
--RELATED_TO--> [?] Human prion diseases
Def: Human prion diseases or transmissible spongiform encephalopathies are rare transmissible diseases affecting the central nervous system. The infectious agents are composed of an abnormal isoform of a h...
--- Walk 2 ---
[1H0Z] Infection, unspecified
--PARENT--> [01] Certain infectious or parasitic diseases
Def: This chapter includes certain conditions caused by pathogenic organisms or microorganisms, such as bacteria, viruses, parasites or fungi....
--CHILD--> [?] Predominantly sexually transmitted infections
--- Walk 3 ---
[1G40] Sepsis without septic shock
Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....
--EXCLUDES--> [?] Septicaemia
--EXCLUDES--> [?] Sepsis without septic shock
Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....
--- Walk 4 ---
[1G40] Sepsis without septic shock
Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....
--EXCLUDES--> [?] Septicaemia
--PARENT--> [?] Bacteraemia
Def: The presence of bacteria in the blood. This can be detected, for example, by a positive blood culture....
--- Walk 5 ---
[FA10.Z] Direct infections of joint, unspecified
--PARENT--> [FA10] Direct infections of joint
Def: Hematogenic or non-hematogenic infections of joints....
--EXCLUDES--> [?] Reactive arthropathies
Def: A disease of the joints, caused by an infection in another part of the body, auto-immune disease, or post-vaccination. This disease is characterised by a secondary inflammation of the joints in reacti...
--- Walk 6 ---
[FA10.Z] Direct infections of joint, unspecified
--PARENT--> [FA10] Direct infections of joint
Def: Hematogenic or non-hematogenic infections of joints....
--CHILD--> [FA10.1] Viral infection of joint
|
[
"[1H0Z] Infection, unspecified\n --PARENT--> [01] Certain infectious or parasitic diseases\n Def: This chapter includes certain conditions caused by pathogenic organisms or microorganisms, such as bacteria, viruses, parasites or fungi....\n --RELATED_TO--> [?] Human prion diseases\n Def: Human prion diseases or transmissible spongiform encephalopathies are rare transmissible diseases affecting the central nervous system. The infectious agents are composed of an abnormal isoform of a h...",
"[1H0Z] Infection, unspecified\n --PARENT--> [01] Certain infectious or parasitic diseases\n Def: This chapter includes certain conditions caused by pathogenic organisms or microorganisms, such as bacteria, viruses, parasites or fungi....\n --CHILD--> [?] Predominantly sexually transmitted infections",
"[1G40] Sepsis without septic shock\n Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....\n --EXCLUDES--> [?] Septicaemia\n --EXCLUDES--> [?] Sepsis without septic shock\n Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....",
"[1G40] Sepsis without septic shock\n Def: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection....\n --EXCLUDES--> [?] Septicaemia\n --PARENT--> [?] Bacteraemia\n Def: The presence of bacteria in the blood. This can be detected, for example, by a positive blood culture....",
"[FA10.Z] Direct infections of joint, unspecified\n --PARENT--> [FA10] Direct infections of joint\n Def: Hematogenic or non-hematogenic infections of joints....\n --EXCLUDES--> [?] Reactive arthropathies\n Def: A disease of the joints, caused by an infection in another part of the body, auto-immune disease, or post-vaccination. This disease is characterised by a secondary inflammation of the joints in reacti...",
"[FA10.Z] Direct infections of joint, unspecified\n --PARENT--> [FA10] Direct infections of joint\n Def: Hematogenic or non-hematogenic infections of joints....\n --CHILD--> [FA10.1] Viral infection of joint"
] |
1H0Z
|
Infection, unspecified
|
[
{
"from_icd11": "1H0Z",
"icd10_code": "B999",
"icd10_title": "Unspecified infectious disease"
},
{
"from_icd11": "1H0Z",
"icd10_code": "A312",
"icd10_title": "Disseminated mycobacterium avium-intracellulare complex (DMAC)"
},
{
"from_icd11": "1H0Z",
"icd10_code": "B998",
"icd10_title": "Other infectious disease"
},
{
"from_icd11": "1H0Z",
"icd10_code": "A249",
"icd10_title": "Melioidosis, unspecified"
},
{
"from_icd11": "1H0Z",
"icd10_code": "R6511",
"icd10_title": "Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction"
},
{
"from_icd11": "1H0Z",
"icd10_code": "R6510",
"icd10_title": "Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction"
},
{
"from_icd11": "1H0Z",
"icd10_code": "A318",
"icd10_title": "Other mycobacterial infections"
},
{
"from_icd11": "1H0Z",
"icd10_code": "A319",
"icd10_title": "Mycobacterial infection, unspecified"
},
{
"from_icd11": "1H0Z",
"icd10_code": "B948",
"icd10_title": "Sequelae of other specified infectious and parasitic diseases"
},
{
"from_icd11": "1H0Z",
"icd10_code": "B949",
"icd10_title": "Sequelae of unspecified infectious and parasitic disease"
},
{
"from_icd11": "1H0Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "1H0Z",
"icd10_code": "N771",
"icd10_title": "Vaginitis, vulvitis and vulvovaginitis in diseases classified elsewhere"
},
{
"from_icd11": "1H0Z",
"icd10_code": "I",
"icd10_title": ""
},
{
"from_icd11": "1H0Z",
"icd10_code": "B90-B94",
"icd10_title": ""
},
{
"from_icd11": "1H0Z",
"icd10_code": "B94",
"icd10_title": "Sequelae of other and unspecified infectious and parasitic diseases"
}
] |
B999
|
Unspecified infectious disease
|
A six-week-old female Hanoverian Scenthound was presented because of a 3 × 4 × 1 cm subcutaneous neoplasm on the left lateral hind limb that was associated with the musculature . The regional lymph node (Ln. popliteus) was not affected. At 2 weeks of age, all puppies had been affected by pyoderma. The puppy was initially treated with Traumeel® (Biologische Heilmittel Heel GmbH, Germany). Two days later, the puppy was presented again as no changes occurred. Pulsation was palpable, and sonography showed an inhomogeneous structure rich in blood vessels. Four weeks after the initial presentation, the mass had grown to 7 × 6 × 1.5 cm and had invaded the surrounding tissue. There was no demarcation to the gastrocnemius muscle and flexor digitalis superficialis muscle and a strong blood supply. The mass and regional lymph node were surgically removed at the owner’s decision. Four days after initial treatment, surgical revision and renewal of vessel ligation were performed due to severe postoperative bleeding in the wound area. Subsequently, wound healing proceeded without complications. At the time of writing (5 months postoperatively) the animal displays no evidence of recurrence and the puppy developed physiologically without loss of performance or physical limitations. The mass and lymph node were sent for histopathologic examination. The samples were processed routinely, and sections were stained with hematoxylin and eosin stain. Immunohistochemistry was performed to detect factor VIII-related antigen (rabbit anti-factor VIII PAP polyclonal, Agilent Technologies®, Waldbronn, Germany; formerly DAKO® Hamburg, Germany), alpha-smooth muscle actin (αSMA; mouse anti-alpha-smooth-muscle-actin ABC monoclonal Agilent Technologies®, Waldbronn, Germany), vimentin (mouse anti-vimentin ABC monoclonal, Agilent Technologies®, Waldbronn, Germany), desmin (mouse anti-desmin ABC monoclonal, Agilent Technologies®, Waldbronn, Germany), pan-cytokeratin (mouse anti-cytokeratin pan ABC monoclonal, OriGene Europe®, Herford, Germany) and melan A (mouse anti-melan A monoclonal, Santa Cruz Biotechnology®, Heidelberg, Germany). Biotinylated horse anti-mouse antibody (Vector Laboratories®, Eching, Germany) and biotinylated pig anti-rabbit antibody (Agilent Technologies®, Waldbronn, Germany) were used as secondary antibodies. Histopathology revealed a multinodular, unencapsulated, well-demarcated, partly infiltrative, moderately cellular subcutaneous mass that replaced subcutaneous adipose tissue and skeletal muscle . The mass consisted of streams and bundles of two populations of cells. One population of plump endothelial cells with a moderate amount of basophilic cytoplasm and a round to oval nucleus with finely stippled chromatin formed slit-shaped vascular channels. The second population consisted of spindle cells with a moderate amount of pale basophilic cytoplasm and oval nuclei with mostly one nucleolus and coarsely clumped chromatin. The spindle cells and a fibrous stroma surrounded the slit vascular channels, occasionally with spindle cells arranged in circular manner around these channels, forming vascular structures . In some areas, the neoplasm consisted only of spindle cells on a fibrous stroma; in others, the spindle cell population was intermingled with the vascular structures or mostly consisted of vascular structures. There was moderate anisocytosis and anisokaryosis. Mitoses were rare in both populations (< 1 mitosis per high power field (HPF) [0,273 cm 2 ]). The tissue was infiltrated with small numbers of lymphocytes, macrophages, and plasma cells. Neutrophilic granulocytes were found in some vascular structures formed by the tumor (not shown). There was mild regeneration of the skeletal musculature. The endothelial cells were positive for factor VIII-related antigen , and a subset of the spindle cells, particularly those encircling slit-like vascular channels, were positive for smooth muscle actin . Both cell populations were positive for vimentin and negative for pan-cytokeratin, desmin and melan A. Follicular hyperplasia, blood resorption and mild sinus histiocytosis were found in the lymph node. The histologic and immunohistological pattern supports the diagnosis of hemangioma. Based on the histological appearance, the neoplasm was classified as a granulation tissue-type hemangioma. Fig. 1 A Mass caudolateral on the left hindlimb before excision: 7 × 6 × 1.5 cm subcutaneous proliferation (arrowheads). B Hematoxylin and eosin-stain: Note the subcutaneous location and demarcation from surrounding tissue (arrows) Fig. 2 A , B HE-stain: Split population of plump endothelial cells with a moderate amount of basophilic cytoplasm and a round to oval nucleus with finely stippled chromatin (arrows) build erythrocyte-filled channels (asterisk) as well as spindle cells with a moderate amount of pale basophilic cytoplasm and oval nuclei with mostly one nucleolus and coarsely clumped chromatin with a fibrous stroma surrounding the vascular structures (arrowheads); C Factor-VIII-related antigen: Positive signal of endothelial cells (arrows); D , E SMA: Mainly positive signal of spindle cells (arrowheads) and negative endothelial cells (arrows)
| 4.183594
| 0.850586
|
sec[1]/p[0]
|
en
| 0.999995
|
36503485
|
https://doi.org/10.1186/s12917-022-03503-1
|
[
"cells",
"germany",
"anti",
"vascular",
"spindle",
"muscle",
"mouse",
"subcutaneous",
"tissue",
"agilent"
] |
[
{
"code": "MF9Y",
"title": "Other specified clinical findings on examination of urine, without diagnosis"
},
{
"code": "5C56.20",
"title": "Mucolipidosis"
},
{
"code": "3A51.1",
"title": "Sickle cell disease without crisis"
},
{
"code": "9A96.3",
"title": "Primary anterior uveitis"
},
{
"code": "3A61.Z",
"title": "Acquired pure red cell aplasia, unspecified"
},
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MB23.1",
"title": "Antisocial behaviour"
},
{
"code": "3B4Z",
"title": "Coagulation defects, unspecified"
},
{
"code": "4A45.Z",
"title": "Antiphospholipid syndrome, unspecified"
},
{
"code": "4A43.Y",
"title": "Other specified overlap non-organ specific systemic autoimmune disease"
}
] |
=== ICD-11 CODES FOUND ===
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
Also known as: Other specified clinical findings on examination of urine, without diagnosis | Methaemoglobinuria | Other and unspecified abnormal findings in urine | Calciuria | Cells and casts in urine
[5C56.20] Mucolipidosis
Also known as: Mucolipidosis | Mucolipidosis type 3 | Pseudo-Hurler polydystrophy | Pseudo-Hurler disease | Mucolipidosis type 2
Excludes: Sialidosis (mucolipidosis type 1)
[3A51.1] Sickle cell disease without crisis
Definition: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may present with fatigue, shortness of breath, dizziness, headaches, pallor of skin or mucous membranes, and jaundice. This disorder is confirmed by identification of HbS mutation by genetic testing.
Also known as: Sickle cell disease without crisis | Hb-SS disease without crisis | HbSS without crisis | Sickle-cell anaemia without crisis | SCD - [sickle cell disease]
[9A96.3] Primary anterior uveitis
Definition: This refers to primary inflammation of the uvea. The uvea consists of the middle, pigmented, vascular structures of the eye and includes the iris, ciliary body, and choroid.
Also known as: Primary anterior uveitis | anterior chamber cell
[3A61.Z] Acquired pure red cell aplasia, unspecified
Also known as: Acquired pure red cell aplasia, unspecified | Acquired pure red cell aplasia | acquired red cell aplasia | red cell aplasia NOS | pure red cell aplastic anaemia
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MB23.1] Antisocial behaviour
Definition: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated.
Also known as: Antisocial behaviour | Child or adolescent antisocial behaviour
[3B4Z] Coagulation defects, unspecified
Also known as: Coagulation defects, unspecified | blood clotting disturbance | blood clotting defect | blood clotting factor deficiency | clotting abnormality
[4A45.Z] Antiphospholipid syndrome, unspecified
Also known as: Antiphospholipid syndrome, unspecified | Antiphospholipid syndrome | Hughes syndrome | Anticardiolipin syndrome
[4A43.Y] Other specified overlap non-organ specific systemic autoimmune disease
Also known as: Other specified overlap non-organ specific systemic autoimmune disease | Antisynthetase syndrome | Reynolds syndrome | Syndromic multisystem autoimmune disease due to ITCH deficiency | Eosinophilia myalgia syndrome
=== GRAPH WALKS ===
--- Walk 1 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--CHILD--> [MF91] Bilirubinuria
Def: Bilirubinuria means the presence of any bile pigment in the urine....
--- Walk 2 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--EXCLUDES--> [?] Inborn errors of amino acid or other organic acid metabolism
--- Walk 3 ---
[5C56.20] Mucolipidosis
--EXCLUDES--> [?] Sialidosis
--CHILD--> [?] Sialidosis type 1
Def: Type 1 sialidosis, also called normomorphic or 'cherry-red-spot, myoclonus' syndrome is a form of sialidosis, a lysosomal storage disease belonging to the group of oligosaccharidoses or glycoproteinos...
--- Walk 4 ---
[5C56.20] Mucolipidosis
--PARENT--> [5C56.2] Glycoproteinosis
Def: These are lysosomal storage diseases affecting glycoproteins, resulting from defects in lysosomal function. The term is sometimes reserved for conditions involving degradation of glycoproteins....
--CHILD--> [5C56.21] Oligosaccharidosis
--- Walk 5 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--CHILD--> [3A51.0] Sickle cell trait
Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ...
--- Walk 6 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--CHILD--> [3A51.2] Sickle cell disease with crisis
Def: Sickle cell crisis occurs when the sickle cells block blood flow, thus decreasing oxygen delivery to the tissues. This results in intense to severe pain in the extremities, lower back, abdomen, and ch...
|
[
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --CHILD--> [MF91] Bilirubinuria\n Def: Bilirubinuria means the presence of any bile pigment in the urine....",
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --EXCLUDES--> [?] Inborn errors of amino acid or other organic acid metabolism",
"[5C56.20] Mucolipidosis\n --EXCLUDES--> [?] Sialidosis\n --CHILD--> [?] Sialidosis type 1\n Def: Type 1 sialidosis, also called normomorphic or 'cherry-red-spot, myoclonus' syndrome is a form of sialidosis, a lysosomal storage disease belonging to the group of oligosaccharidoses or glycoproteinos...",
"[5C56.20] Mucolipidosis\n --PARENT--> [5C56.2] Glycoproteinosis\n Def: These are lysosomal storage diseases affecting glycoproteins, resulting from defects in lysosomal function. The term is sometimes reserved for conditions involving degradation of glycoproteins....\n --CHILD--> [5C56.21] Oligosaccharidosis",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --CHILD--> [3A51.0] Sickle cell trait\n Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ...",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --CHILD--> [3A51.2] Sickle cell disease with crisis\n Def: Sickle cell crisis occurs when the sickle cells block blood flow, thus decreasing oxygen delivery to the tissues. This results in intense to severe pain in the extremities, lower back, abdomen, and ch..."
] |
MF9Y
|
Other specified clinical findings on examination of urine, without diagnosis
|
[
{
"from_icd11": "3A51.1",
"icd10_code": "D571",
"icd10_title": "Sickle-cell disease without crisis"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D609",
"icd10_title": "Acquired pure red cell aplasia, unspecified"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D608",
"icd10_title": "Other acquired pure red cell aplasias"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D60",
"icd10_title": "Acquired pure red cell aplasia [erythroblastopenia]"
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D688",
"icd10_title": "Other specified coagulation defects"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D689",
"icd10_title": "Coagulation defect, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D699",
"icd10_title": "Hemorrhagic condition, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D698",
"icd10_title": "Other specified hemorrhagic conditions"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D65-D69",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D69",
"icd10_title": "Purpura and other hemorrhagic conditions"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6861",
"icd10_title": "Antiphospholipid syndrome"
}
] |
D571
|
Sickle-cell disease without crisis
|
The patient was a 50-year-old man. The patient’s father passed away due to tuberculosis and respiratory failure, while his mother remains in good health. The patient has two sisters and a half-brother, all of whom are healthy. At present, the patient does not have any children. He presented with chest tightness, chest and back pain, cough, blood in the sputum, and hypodynamia. The patient had a smoking history of 20 years before developing lung disease. Before the development of the disease, the patient had good health and no reported history of occupational exposure or genetic predisposition within the family. Contrast-enhanced computed tomography (CT) examination of the chest at presentation showed an upper left lung mass shadow (10.7 cm × 8.5 cm × 10.5 cm). The margin was poorly demarcated from the mediastinal pleura comprising multiple flaky low-density necrotic areas. The CT value ranged from 19 to 33 Hu. Whole-body positron emission tomography (PET)-CT scan revealed a mass hypermetabolic lesion in the upper left lung (SUV 8.5) and was considered upper left lung cancer. The lesion was infiltrated along the adjacent bronchial and pleural. And it was intricately related to the aortic arch with peripheral obstructive inflammation. Mild hypermetabolism (SUV 3.0) of left hilar and mediastinal lymph nodes (groups 5 and 6) reflected lymph node metastasis. No metastases were seen elsewhere throughout the body. Blood tumor markers (CEA, NSE, and CYFRA21–1) were normal. Examination of fine-needle aspiration biopsy of the lesion via CT revealed that tumor cells were spindle-shaped or oval, with diffuse infiltrative growth, necrosis of a small number of cartilage components, and loose interstitium. The tumor tissue consisted of both epithelial and mesenchymal tissues, with the epithelial component exhibiting features of low-grade adenocarcinoma. The mesenchymal component, on the other hand, exhibited characteristics of sarcoma with cartilage metaplasia, as illustrated in Figure 1 . This was consistent with the diagnosis of PB. Immunohistochemistry revealed epithelial components: CK (+), TTF1 (+), CEA (–), CK7 focal (+), CK5/6 focal (+), S-100 focal (+), EMA focal (+); mesenchymal components: Vim (+), S-100 focal (+), Des small (+), CD99 individual (+), CD34 vascular (+), MC (-), Napsin A (-), and Ki-67 (30% +) . Due to the limited tissue sample available, certain immunotherapy predictors, including PD-L1, tumor mutation burden (TMB), and microsatellite stability (MSS), were not evaluated. The diagnosis was classic biphasic PB, and the clinical tumor stage was cT4N2M0 IIIB. The tumor could not be resected because the patient’s tumor was closely related to the aortic arch. Therefore, the multiple disciplinary teams (MDTs) believed that radical surgery could be performed. The first-line chemotherapy regimen included paclitaxel 175 mg/m 2 (day 1) + cisplatin 25 mg/m 2 (day 1–day 3), with a total of four cycles. Chest radiotherapy was given one month after chemotherapy at a dose of 75 Gy/35f, and efficacy was assessed as partial response (PR) after sequential chemoradiotherapy. Follow-up was repeated every three months following the first-line treatment, and PFS was 12.3 months. The patient reported worsening chest pain, with the chest CT showing that the lesion was progressing. The left upper lung lesion was markedly enlarged, and solid changes appeared. The patient experienced difficulty falling asleep due to chest pain, requiring Oxycodone Hydrochloride Controlled-release Tablets at a dosage of 360 mg q12 h to achieve a Numerical Rating Scale (NRS) score below 3. This pain level significantly impacted the patient’s ability to work and carry out daily activities. As a distinct subtype of NSCLC, classical biphasic PB (CBPB) poses challenges for second-line chemotherapy alone, and no known driver gene mutation is currently suitable for targeted therapy in this condition. Previous reports have demonstrated that PD-L1 expression was observed in roughly 12% of PPB patients ( 5 ). Furthermore, case studies have identified high PD-L1 expression in patients with CBPB ( 6 ). As such, the combination of chemotherapy and ICIs was considered a potential treatment approach. The treatment was changed to gemcitabine 1250 mg/m 2 (d1, 8) and sintilimab 200 mg (d1). After one cycle of treatment, the patient developed third-degree neutropenia, a second-degree rash, and anorexia; we attributed these side effects to gemcitabine. Gemcitabine chemotherapy was discontinued at the patient’s insistence, and only sintilimab immunomonotherapy was administered. Over time, the patient’s chest pain gradually subsided, and they were able to resume daily activities. The dosage of Oxycodone Hydrochloride Controlled-release Tablets was consequently reduced to 80 mg q12 h. No significant adverse effects were observed during this treatment period. Based on imaging evaluations, the patient’s disease state remained stable, classified as stable disease (SD) . The patient is currently receiving sintilimab for 27 months. His condition was stable, with a performance status (PS) score of 1. The patient has been alive for nearly 40 months and has a good quality of life.
| 4.164063
| 0.965332
|
sec[1]/p[0]
|
en
| 0.999996
|
PMC10130361
|
https://doi.org/10.3389/fonc.2023.1146204
|
[
"chest",
"tumor",
"pain",
"lung",
"lesion",
"chemotherapy",
"that",
"this",
"good",
"components"
] |
[
{
"code": "CB7Z",
"title": "Diseases of the respiratory system, unspecified"
},
{
"code": "CB27",
"title": "Pleural effusion"
},
{
"code": "CA44",
"title": "Pyothorax"
},
{
"code": "MD30.Z",
"title": "Chest pain, unspecified"
},
{
"code": "NA80.Y&XJ1C6",
"title": "Thoracic haematoma"
},
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
}
] |
=== ICD-11 CODES FOUND ===
[CB7Z] Diseases of the respiratory system, unspecified
Also known as: Diseases of the respiratory system, unspecified | disorder of respiratory system | respiratory disease NOS | respiratory tract disease | respiratory disorder NOS
[CB27] Pleural effusion
Definition: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces.
Also known as: Pleural effusion | PE - [pleural effusion] | Pleurisy with effusion | pleurisy with effusion NOS | pleural effusion with transudate
Includes: Pleurisy with effusion
Excludes: Tuberculosis of the respiratory system | Chylous effusion | Pleurisy
[CA44] Pyothorax
Definition: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or penetrating trauma with a secondary infection.
Also known as: Pyothorax | empyema | pyopneumothorax | Pyothorax with fistula | empyema with fistula
Includes: empyema | pyopneumothorax
Excludes: due to tuberculosis
[MD30.Z] Chest pain, unspecified
Also known as: Chest pain, unspecified | Pain in throat or chest | chest pain NOS | pain in chest | chest pressure
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--RELATED_TO--> [?] Symptoms, signs or clinical findings of the respiratory system
--- Walk 2 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases
Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....
--- Walk 3 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Chylous effusion
Def: A chylothorax (chylous effusion) signifies leakage of chyle from the thoracic duct. A pleural fluid triglyceride concentration of more than 110 mg per decilitre signifies a high likelihood of chylotho...
--PARENT--> [?] Other pleural conditions
Def: Any other condition effecting the thin serous membrane enveloping the lungs and lining the thoracic cavity...
--- Walk 4 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Pleurisy
Def: Pleurisy or Pleuritis is the medical term for inflammation of the pleura. The most common cause of pleuritis is infection, but it can also be caused by lupus, rheumatoid arthritis, and certain medicin...
--CHILD--> [?] Acute pleurisy
--- Walk 5 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...
--- Walk 6 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...
|
[
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --RELATED_TO--> [?] Symptoms, signs or clinical findings of the respiratory system",
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases\n Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Chylous effusion\n Def: A chylothorax (chylous effusion) signifies leakage of chyle from the thoracic duct. A pleural fluid triglyceride concentration of more than 110 mg per decilitre signifies a high likelihood of chylotho...\n --PARENT--> [?] Other pleural conditions\n Def: Any other condition effecting the thin serous membrane enveloping the lungs and lining the thoracic cavity...",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Pleurisy\n Def: Pleurisy or Pleuritis is the medical term for inflammation of the pleura. The most common cause of pleuritis is infection, but it can also be caused by lupus, rheumatoid arthritis, and certain medicin...\n --CHILD--> [?] Acute pleurisy",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba..."
] |
CB7Z
|
Diseases of the respiratory system, unspecified
|
[
{
"from_icd11": "CB7Z",
"icd10_code": "J989",
"icd10_title": "Respiratory disorder, unspecified"
},
{
"from_icd11": "CB7Z",
"icd10_code": "X",
"icd10_title": ""
},
{
"from_icd11": "CB7Z",
"icd10_code": "J09-J18",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J910",
"icd10_title": "Malignant pleural effusion"
},
{
"from_icd11": "CB27",
"icd10_code": "J918",
"icd10_title": "Pleural effusion in other conditions classified elsewhere"
},
{
"from_icd11": "CB27",
"icd10_code": "J90",
"icd10_title": "Pleural effusion, not elsewhere classified"
},
{
"from_icd11": "CB27",
"icd10_code": "J90-J94",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J91",
"icd10_title": "Pleural effusion in conditions classified elsewhere"
},
{
"from_icd11": "CA44",
"icd10_code": "J869",
"icd10_title": "Pyothorax without fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J860",
"icd10_title": "Pyothorax with fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J85-J86",
"icd10_title": ""
},
{
"from_icd11": "CA44",
"icd10_code": "J86",
"icd10_title": "Pyothorax"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0781",
"icd10_title": "Pleurodynia"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0782",
"icd10_title": "Intercostal pain"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R079",
"icd10_title": "Chest pain, unspecified"
}
] |
J989
|
Respiratory disorder, unspecified
|
Three women with preterm pregnancy and co-existing epilepsy arrived at hospital with uncontrollable fits due to either discontinuation of treatment or irregular use of anticonvulsive therapy. They were delivered by emergency CS on suspicion of eclampsia while adequate history taking and initial assessment did not take place. Audits of CTG traces could only confirm abnormal CTG in 20% of those near-miss cases that delivered by CS due to foetal distress. There was no CTG documentation confirming foetal distress in 60% of cases and the opportunity for adequate assessment of CTG trace was missed in the remaining 20%. Tables 5 , 6 and 7 present examples of MNM cases and the related clinical judgements. Table 5 Example of missed opportunities linked to care items for obstetric haemorrhage Case 1 A 21-year-old Afghan mother, 0P, in 38 weeks of gestation, was admitted to hospital with labour pains in latent phase. She was delivered by emergency CS due to foetal distress on the day shift. Ten hours after operation she was pale, had pre-shock status, and the reported haemoglobin level was 7.4 g/dl. Re-operation was performed, a very large hematoma in left broad ligament was detected, and 12 units of different blood products were transfused. She went back to the hospital two weeks after discharge due to fever and haematuria. Further examination revealed left ureter injury. Care items Audit findings Initial assessment Foetal heart rates were monitored and assessed inadequately. Recognition No evidence was found to agree foetal distress. Intra-abdominal hematoma was recognised with delay. Care plan The indicated evidence for emergency CS was missing. Monitoring Postpartum controls early after CS were not documented and were inadequate for early detection of intra-abdominal bleeding. Preventability Near-miss events (decreased haemoglobin, re-operation, blood transfusion) and the injured ureter could have potentially been prevented by better obstetric practice (provider-related). Table 6 Example of missed opportunities linked to care items for placenta previa Case 2 A 36-year-old native mother, 2P, with two previous CS was admitted to hospital due to low back pain in 39 + 3 weeks of gestation. According to ultrasound examinations during antenatal visits, she had low-lying placenta previa. Emergency CS was performed two hours after admission on the night shift and the operation ended up with CS hysterectomy due to abnormal invasive placenta. More than 20 units of blood products were transfused, the mother was admitted at intensive care unit and had long-lasting intubation. Pathologic examination of uterus specimen revealed placenta increta. Care items Audit findings Antenatal care Despite two previous CS and low-lying placenta previa, examination of placental orientation for better obstetric plan during pregnancy was not conducted. Despite repeat CS and previa, no elective surgery was planned. Referral system No timely referral from antenatal clinic to the hospital was made. Initial assessment Despite risk for abnormal invasive placenta, no assessment at hospital was performed. Recognition Recognition of abnormally invasive placenta in a high-risk mother was missed before operation room. Care plan No evidence was found indicating acute CS on the night shift for a high-risk surgery. Documentation Estimation of blood loss during operation was not documented. Near-miss events such as the amount of administered blood, admission to intensive care unit, and long-lasting intubation were not documented in summary notes. Preventability The near-miss events could have potentially become less critical and traumatic for woman and her family by better obstetric practice (provider-related). Table 7 Example of missed opportunities linked with sepsis and postpartum haemorrhage Case 3 A 24-year-old Afghan mother, 3P, was admitted to hospital one week after home delivery with long-lasting bleeding, weakness, and high fever. She was in pre-shock status and the reported haemoglobin level was 5.6 g/dl. She was resuscitated with blood transfusion and was treated with intravenous antibiotic due to postpartum endometritis. Ultrasound examination was done after three days and retained placenta was detected. Fever went down after evacuation and curettage and she chose to leave the hospital before doctor’s recommendation. She was interviewed afterward and said that the family could not afford the cost of hospital obstetric services. Care items Audit findings Initial assessment Despite home delivery and the risk of retained placenta, history taking and initial examination of uterus cavity were incomplete. Recognition Delayed recognition of retained placenta in a mother with anaemia and postpartum endometritis was identified. Care plan The management of postpartum endometritis and retained placenta were inappropriate. Documentation Previous obstetric history and risk of postpartum haemorrhage, antenatal visits and delivery process at home for index pregnancy were not documented. Preventability The near-miss events could have potentially prevented by affordable safe childbirth (health system) and timely care-seeking (patient). Hospital care was also suboptimal.
| 4.050781
| 0.922852
|
sec[2]/sec[0]/p[4]
|
en
| 0.999995
|
28193186
|
https://doi.org/10.1186/s12884-017-1239-2
|
[
"placenta",
"obstetric",
"mother",
"blood",
"postpartum",
"near",
"miss",
"foetal",
"missed",
"items"
] |
[
{
"code": "JA8A.1",
"title": "Malformation of placenta"
},
{
"code": "JA8A.Y",
"title": "Other specified maternal care related to placental disorders"
},
{
"code": "JA8B.Z",
"title": "Maternal care related to placenta praevia or low lying placenta, unspecified"
},
{
"code": "JA86.4",
"title": "Maternal care for fetal growth restriction"
},
{
"code": "2F96&XA90F8",
"title": "Neoplasms of unknown behaviour of placenta"
},
{
"code": "JB6Z",
"title": "Unspecified obstetric condition"
},
{
"code": "JB0D",
"title": "Certain specified complications of labour or delivery, not elsewhere classified"
},
{
"code": "GC04.1Z",
"title": "Fistulae involving female genital tract, unspecified"
},
{
"code": "JB42.Z",
"title": "Obstetric embolism, unspecified"
},
{
"code": "JB42.Y",
"title": "Other specified obstetric embolism"
}
] |
=== ICD-11 CODES FOUND ===
[JA8A.1] Malformation of placenta
Also known as: Malformation of placenta | variation of placenta form | deformity of placenta | placental deformity | Abnormal placenta NOS
[JA8A.Y] Other specified maternal care related to placental disorders
Also known as: Other specified maternal care related to placental disorders | Obliteration of placental blood vessels | Placenta dysfunction syndrome | placental dysfunction syndrome | placental dysfunction
[JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified
Also known as: Maternal care related to placenta praevia or low lying placenta, unspecified | Maternal care related to placenta praevia or low lying placenta | lateral placenta | total placenta previa | PP - [placenta previa]
[JA86.4] Maternal care for fetal growth restriction
Also known as: Maternal care for fetal growth restriction | maternal care for intrauterine growth retardation | Maternal care for known or suspected: small-for-gestational age | intrauterine growth retardation affecting management of pregnancy | light-for-dates affecting management of pregnancy
[JB6Z] Unspecified obstetric condition
Also known as: Unspecified obstetric condition
[JB0D] Certain specified complications of labour or delivery, not elsewhere classified
Also known as: Certain specified complications of labour or delivery, not elsewhere classified | delivery complications NOS | labour complications NOS | obstetrical complications NOS
Excludes: Infections in the puerperium | Puerperal sepsis
[GC04.1Z] Fistulae involving female genital tract, unspecified
Also known as: Fistulae involving female genital tract, unspecified | Fistulae involving female genital tract | fistula of the female genital organs | fistula of the female genital tract | genital tract fistula
[JB42.Z] Obstetric embolism, unspecified
Also known as: Obstetric embolism, unspecified | Obstetric embolism | Obstetric embolism NOS
[JB42.Y] Other specified obstetric embolism
Also known as: Other specified obstetric embolism | Obstetric fat embolism | obstetrical pulmonary fat embolism | fat embolism complicating delivery | puerperal fat embolism
=== GRAPH WALKS ===
--- Walk 1 ---
[JA8A.1] Malformation of placenta
--PARENT--> [JA8A] Maternal care related to placental disorders
--CHILD--> [JA8A.0] Placental transfusion syndromes
--- Walk 2 ---
[JA8A.1] Malformation of placenta
--PARENT--> [JA8A] Maternal care related to placental disorders
--CHILD--> [JA8A.0] Placental transfusion syndromes
--- Walk 3 ---
[JA8A.Y] Other specified maternal care related to placental disorders
--PARENT--> [JA8A] Maternal care related to placental disorders
--CHILD--> [JA8A.0] Placental transfusion syndromes
--- Walk 4 ---
[JA8A.Y] Other specified maternal care related to placental disorders
--PARENT--> [JA8A] Maternal care related to placental disorders
--EXCLUDES--> [?] Maternal care related to placenta praevia or low lying placenta
Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...
--- Walk 5 ---
[JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified
--PARENT--> [JA8B] Maternal care related to placenta praevia or low lying placenta
Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...
--CHILD--> [JA8B.1] Placenta praevia with haemorrhage
--- Walk 6 ---
[JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified
--PARENT--> [JA8B] Maternal care related to placenta praevia or low lying placenta
Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...
--CHILD--> [JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified
|
[
"[JA8A.1] Malformation of placenta\n --PARENT--> [JA8A] Maternal care related to placental disorders\n --CHILD--> [JA8A.0] Placental transfusion syndromes",
"[JA8A.1] Malformation of placenta\n --PARENT--> [JA8A] Maternal care related to placental disorders\n --CHILD--> [JA8A.0] Placental transfusion syndromes",
"[JA8A.Y] Other specified maternal care related to placental disorders\n --PARENT--> [JA8A] Maternal care related to placental disorders\n --CHILD--> [JA8A.0] Placental transfusion syndromes",
"[JA8A.Y] Other specified maternal care related to placental disorders\n --PARENT--> [JA8A] Maternal care related to placental disorders\n --EXCLUDES--> [?] Maternal care related to placenta praevia or low lying placenta\n Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...",
"[JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified\n --PARENT--> [JA8B] Maternal care related to placenta praevia or low lying placenta\n Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...\n --CHILD--> [JA8B.1] Placenta praevia with haemorrhage",
"[JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified\n --PARENT--> [JA8B] Maternal care related to placenta praevia or low lying placenta\n Def: A placenta that is implanted over or very near the internal cervical os--total, partial, marginal, low-lying placenta...\n --CHILD--> [JA8B.Z] Maternal care related to placenta praevia or low lying placenta, unspecified"
] |
JA8A.1
|
Malformation of placenta
|
[
{
"from_icd11": "JA8A.1",
"icd10_code": "O43123",
"icd10_title": "Velamentous insertion of umbilical cord, third trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43193",
"icd10_title": "Other malformation of placenta, third trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43122",
"icd10_title": "Velamentous insertion of umbilical cord, second trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43113",
"icd10_title": "Circumvallate placenta, third trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43192",
"icd10_title": "Other malformation of placenta, second trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43103",
"icd10_title": "Malformation of placenta, unspecified, third trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43101",
"icd10_title": "Malformation of placenta, unspecified, first trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O43102",
"icd10_title": "Malformation of placenta, unspecified, second trimester"
},
{
"from_icd11": "JA8A.1",
"icd10_code": "O431",
"icd10_title": "Malformation of placenta"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O4443",
"icd10_title": "Low lying placenta NOS or without hemorrhage, third trimester"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O4452",
"icd10_title": "Low lying placenta with hemorrhage, second trimester"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O4442",
"icd10_title": "Low lying placenta NOS or without hemorrhage, second trimester"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O4423",
"icd10_title": "Partial placenta previa NOS or without hemorrhage, third trimester"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O4453",
"icd10_title": "Low lying placenta with hemorrhage, third trimester"
},
{
"from_icd11": "JA8B.Z",
"icd10_code": "O44",
"icd10_title": "Placenta previa"
}
] |
O43123
|
Velamentous insertion of umbilical cord, third trimester
|
Abdominal computed tomography (CT) showed slight enlargement of both kidneys (right, 12 × 7 cm; left, 11 × 6 cm) . Hepatitis virus antigen/antibody tests were negative on admission and there was no history of drinking; however, hepatobiliary enzymes were elevated. In addition, abdominal CT showed splenohepatomegaly . For the systemic rash, the patient was referred to the dermatology department on the day of admission, and a skin biopsy was performed. The rash was suspected to be an adverse effect of a drug; therefore, use of the previously prescribed drug was discontinued. The patient was also referred to the ophthalmology department for her blurred vision. Cataracts and uveitis were observed, along with increased intraocular pressure (IOP) (left IOP, 14 mmHg; right IOP, 13 mmHg). Abdominal CT did not reveal obstruction of the urinary tract, thus ruling out postrenal failure. Assuming the possibility of a prerenal failure, we administered extracellular fluid to maintain the hemodynamics. However, there was no improvement in renal function. We then suspected rapidly progressive renal failure with renal parenchyma involvement, or interstitial failure. Among the causes of rapidly progressive renal failure, we suspected nephrotoxic medications or glomerulonephritis due to membrane-type lupus nephritis or renal lymphoma. During hospitalization, her IOP further increased (left IOP, 35 mmHg; right IOP, 37 mmHg), for which various eye drops (steroids, prostaglandin-related drugs, beta-blocking drugs, adrenergic alpha 2 receptor agonists, carbonic anhydrase inhibitors, rho kinase inhibitors) were administered. However, there was no improvement. We administered oral steroids (prednisolone 30 mg/day) to prevent blindness and protect the kidneys. An improvement in the eye symptoms was detected. On day 3 of hospitalization, we performed a renal biopsy to determine the cause of rapidly progressive renal failure. In addition, after renal biopsy, we administered pulse steroid therapy (methylprednisolone 500 mg/day for 3 days) to protect the kidneys and further improve the eye symptoms . The response to pulse steroid therapy was good and renal function gradually improved (day 3 of hospitalization, Cr 3.22 mg/dL; day 5, Cr 2.06 mg/dL; day 8, Cr 1.13 mg/dL) . One complete course of pulse steroid therapy was administered and the dose of prednisolone was decreased to 20 mg/day from day 18. Elevated hepatobiliary enzymes gradually improved with steroids . The systemic rash and itching sensation began to dissipate, although pigmentation was still visible. Her vision improved and IOP decreased, thus blindness was prevented. On day 22, a diagnosis of tubulointerstitial nephritis due to tubulointerstitial infiltration of PTCL-NOS was made, based on the results of renal biopsy (hematoxylin-eosin staining showed the presence of atypical lymphocytes; immunostaining showed that CD2, CD3, and CD4 were positive and CD5, CD7, CD8, and CD20 were negative) and a Ki-67 score of approximately 80%. We also diagnosed subcutaneous tissue infiltration of PTCL-NOS, based on the results of skin biopsy (hematoxylin-eosin staining showed the presence of atypical lymphocytes; immunostaining showed that CD2, CD3, and CD4 were positive and CD5, CD7, CD8, and CD20 were negative) and a Ki-67 score of approximately 80%. We performed flow cytometric analysis of the kidney and skin tissue, which showed similar results. We performed Southern blot analysis on kidney and skin tissue, but we could not obtain the result because of small amount of DNA. A presumptive diagnosis of PTCL-NOS to the liver and spleen and existence of Uveitis masquerade syndrome due to PTCL-NOS was made based on the clinical course. Since lymph node lesions were not seen on imaging, we assumed that the lesions were limited to extralymphatic organs. In addition, we performed a spinal fluid test and found an atypical lymphocyte count of 5%. These atypical lymphocytes showed the same findings on flow cytometric analysis as those in the kidney and skin. The patient was referred to the hematology department and initial CHOP therapy was administered on day 23 of hospitalization. Fig. 2 Abdominal computed tomography (CT) showing slight enlargement of both kidneys (right, 12 × 7 cm; left, 11 × 6 cm) Fig. 3 Abdominal computed tomography (CT) showing splenohepatomegaly (major axis of the spleen, 10.5 cm; size of the right hepatic lobe, 15.0 cm; size of the left hepatic left lobe, 12.0 cm) Fig. 4 Clinical course of this case ALP (alkaline phosphatase); Cr (creatinine); γ-GTP (γ-glutamyl transpeptidase); PSL (prednisolone) Fig. 5 Renal histopathological findings. a , b Hematoxylin-eosin staining showing tubulointerstitial infiltration of atypical lymphocytes. c Immunostaining showing a high degree of CD3 expression in the tubule interstitium. d Immunostaining did not show CD20 expression in the tubule interstitium Fig. 6 Dermat histopathological findings. a , b Hematoxylin-eosin staining showing subcutaneous tissue infiltration of atypical lymphocytes. c Immunostaining showing a high degree of CD3 expression in the subcutaneous tissue. d Immunostaining did not show CD20 expression in the subcutaneous tissue
| 3.939453
| 0.978027
|
sec[1]/p[1]
|
en
| 0.999996
|
30409117
|
https://doi.org/10.1186/s12882-018-1125-9
|
[
"renal",
"failure",
"atypical",
"immunostaining",
"tissue",
"abdominal",
"skin",
"biopsy",
"lymphocytes",
"kidneys"
] |
[
{
"code": "GC2Z&XA6KU8",
"title": "Disease of kidney, not elsewhere classified"
},
{
"code": "GB6Z",
"title": "Kidney failure, unspecified"
},
{
"code": "LB30.1",
"title": "Renal dysplasia"
},
{
"code": "NB92.0Y",
"title": "Other specified injury of kidney"
},
{
"code": "LB30.7",
"title": "Ectopic or pelvic kidney"
},
{
"code": "DA96.05",
"title": "Intestinal failure"
},
{
"code": "MG4A",
"title": "Multi organ failure"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "CB41.2Z",
"title": "Respiratory failure, unspecified"
},
{
"code": "5C50.01",
"title": "Nonclassical phenylketonuria"
}
] |
=== ICD-11 CODES FOUND ===
[GB6Z] Kidney failure, unspecified
Also known as: Kidney failure, unspecified | nontraumatic kidney injury | renal failure NOS | kidney block | renal impairment NOS
[LB30.1] Renal dysplasia
Definition: A condition characterised by abnormal development of one or both kidneys.
Also known as: Renal dysplasia | congenital renal dysplasia | dysplasia of kidney | dysplastic kidney | Primary renal dysplasia
Excludes: Autosomal dominant polycystic kidney disease
[NB92.0Y] Other specified injury of kidney
Also known as: Other specified injury of kidney | Injury of kidney without open wound into cavity | Injury of kidney with open wound into cavity | Haematoma of kidney | traumatic perirenal haematoma
[LB30.7] Ectopic or pelvic kidney
Definition: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones
Also known as: Ectopic or pelvic kidney | Congenital displaced kidney | congenital misplaced kidney | congenital malposition of kidney | congenital prolapsed kidney
Includes: Congenital displaced kidney | Malrotation of kidney
[DA96.05] Intestinal failure
Definition: The reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth.
Also known as: Intestinal failure
[MG4A] Multi organ failure
Definition: Failure of function of more than one organ or organ system, not otherwise specified
Also known as: Multi organ failure | MODS - [multi organ dysfunction syndrome] | multiple organ failure | multisystem organ failure | multiorgan failure syndrome
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[CB41.2Z] Respiratory failure, unspecified
Also known as: Respiratory failure, unspecified | Respiratory failure, unspecified as acute or chronic | respiration failure | respiratory failure NOS | respiration failed
[5C50.01] Nonclassical phenylketonuria
Definition: Mild phenylketonuria is a rare form of phenylketonuria (PKU), an inborn error of amino acid metabolism, characterised by symptoms of PKU of mild to moderate severity.
Also known as: Nonclassical phenylketonuria | Atypical phenylketonuria | Atypical PKU - [phenylketonuria]
=== GRAPH WALKS ===
--- Walk 1 ---
[GB6Z] Kidney failure, unspecified
--PARENT--> [?] Kidney failure
Def: Inability of the kidneys to adequately filter the blood of waste products, with a lower than normal glomerular filtration rate (GFR). Can be abrupt and potentially reversible (acute kidney injury) or ...
--CHILD--> [GB61] Chronic kidney disease
Def: Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m² or presence of kidney damage that is present for more than 3 months. Evidence of kidney damage can include structural abnormalities (imaging or hist...
--- Walk 2 ---
[GB6Z] Kidney failure, unspecified
--PARENT--> [?] Kidney failure
Def: Inability of the kidneys to adequately filter the blood of waste products, with a lower than normal glomerular filtration rate (GFR). Can be abrupt and potentially reversible (acute kidney injury) or ...
--CHILD--> [GB61] Chronic kidney disease
Def: Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m² or presence of kidney damage that is present for more than 3 months. Evidence of kidney damage can include structural abnormalities (imaging or hist...
--- Walk 3 ---
[LB30.1] Renal dysplasia
Def: A condition characterised by abnormal development of one or both kidneys....
--EXCLUDES--> [?] Autosomal dominant polycystic kidney disease
Def: Multiple cysts in both kidneys increasing in number and size from adolescence, associated with development of hypertension and chronic renal failure. Autosomal dominant familial pattern is usual and d...
--CHILD--> [?] Autosomal dominant polycystic kidney disease, Type 2
Def: Autosomal dominant polycystic kidney disease due to mutations on Polycystin2 gene on chromosome 4 (PKD1 gene)....
--- Walk 4 ---
[LB30.1] Renal dysplasia
Def: A condition characterised by abnormal development of one or both kidneys....
--PARENT--> [LB30] Structural developmental anomalies of kidneys
Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....
--CHILD--> [LB30.1] Renal dysplasia
Def: A condition characterised by abnormal development of one or both kidneys....
--- Walk 5 ---
[NB92.0Y] Other specified injury of kidney
--PARENT--> [NB92.0] Injury of kidney
--PARENT--> [NB92] Injury of urinary or pelvic organs
--- Walk 6 ---
[NB92.0Y] Other specified injury of kidney
--PARENT--> [NB92.0] Injury of kidney
--CHILD--> [NB92.00] Contusion of kidney, minor
|
[
"[GB6Z] Kidney failure, unspecified\n --PARENT--> [?] Kidney failure\n Def: Inability of the kidneys to adequately filter the blood of waste products, with a lower than normal glomerular filtration rate (GFR). Can be abrupt and potentially reversible (acute kidney injury) or ...\n --CHILD--> [GB61] Chronic kidney disease\n Def: Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m² or presence of kidney damage that is present for more than 3 months. Evidence of kidney damage can include structural abnormalities (imaging or hist...",
"[GB6Z] Kidney failure, unspecified\n --PARENT--> [?] Kidney failure\n Def: Inability of the kidneys to adequately filter the blood of waste products, with a lower than normal glomerular filtration rate (GFR). Can be abrupt and potentially reversible (acute kidney injury) or ...\n --CHILD--> [GB61] Chronic kidney disease\n Def: Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m² or presence of kidney damage that is present for more than 3 months. Evidence of kidney damage can include structural abnormalities (imaging or hist...",
"[LB30.1] Renal dysplasia\n Def: A condition characterised by abnormal development of one or both kidneys....\n --EXCLUDES--> [?] Autosomal dominant polycystic kidney disease\n Def: Multiple cysts in both kidneys increasing in number and size from adolescence, associated with development of hypertension and chronic renal failure. Autosomal dominant familial pattern is usual and d...\n --CHILD--> [?] Autosomal dominant polycystic kidney disease, Type 2\n Def: Autosomal dominant polycystic kidney disease due to mutations on Polycystin2 gene on chromosome 4 (PKD1 gene)....",
"[LB30.1] Renal dysplasia\n Def: A condition characterised by abnormal development of one or both kidneys....\n --PARENT--> [LB30] Structural developmental anomalies of kidneys\n Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....\n --CHILD--> [LB30.1] Renal dysplasia\n Def: A condition characterised by abnormal development of one or both kidneys....",
"[NB92.0Y] Other specified injury of kidney\n --PARENT--> [NB92.0] Injury of kidney\n --PARENT--> [NB92] Injury of urinary or pelvic organs",
"[NB92.0Y] Other specified injury of kidney\n --PARENT--> [NB92.0] Injury of kidney\n --CHILD--> [NB92.00] Contusion of kidney, minor"
] |
GC2Z&XA6KU8
|
Disease of kidney, not elsewhere classified
|
[
{
"from_icd11": "GB6Z",
"icd10_code": "N19",
"icd10_title": "Unspecified kidney failure"
},
{
"from_icd11": "GB6Z",
"icd10_code": "N17-N19",
"icd10_title": ""
},
{
"from_icd11": "GB6Z",
"icd10_code": "N17",
"icd10_title": "Acute kidney failure"
},
{
"from_icd11": "LB30.1",
"icd10_code": "Q614",
"icd10_title": "Renal dysplasia"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q632",
"icd10_title": "Ectopic kidney"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q63",
"icd10_title": "Other congenital malformations of kidney"
},
{
"from_icd11": "CB41",
"icd10_code": "J9622",
"icd10_title": "Acute and chronic respiratory failure with hypercapnia"
},
{
"from_icd11": "CB41",
"icd10_code": "J9620",
"icd10_title": "Acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia"
},
{
"from_icd11": "CB41",
"icd10_code": "J96",
"icd10_title": "Respiratory failure, not elsewhere classified"
},
{
"from_icd11": "CB41.2Z",
"icd10_code": "J9691",
"icd10_title": "Respiratory failure, unspecified with hypoxia"
},
{
"from_icd11": "CB41.2Z",
"icd10_code": "J9690",
"icd10_title": "Respiratory failure, unspecified, unspecified whether with hypoxia or hypercapnia"
},
{
"from_icd11": "CB41.2Z",
"icd10_code": "J9692",
"icd10_title": "Respiratory failure, unspecified with hypercapnia"
},
{
"from_icd11": "CB41.2Z",
"icd10_code": "J9621",
"icd10_title": "Acute and chronic respiratory failure with hypoxia"
},
{
"from_icd11": "CB41.2Z",
"icd10_code": "J969",
"icd10_title": "Respiratory failure, unspecified"
},
{
"from_icd11": "5C50.01",
"icd10_code": "E701",
"icd10_title": "Other hyperphenylalaninemias"
}
] |
N19
|
Unspecified kidney failure
|
The patient was a 56-year-old woman who underwent embolization of an intracranial aneurysm 2.5 years before presentation. The patient was admitted to the hospital on June 20, 2019 with a sudden onset of impaired consciousness, headache, dizziness, and vomiting for 4 h. Cranial CT revealed subarachnoid hemorrhage, which was considered a ruptured intracranial aneurysm. Total cerebral angiography and interventional embolization of the intracranial aneurysm were performed under general anesthesia. Intraoperatively, abnormal protrusion of the apical portion of the basilar artery measuring approximately 3.37 × 2.14 × 2.82 mm 3 was found, and tight embolization was performed. According to the records, the duration of the surgery was 1.5 h. The patient received a radiation dose of 1367.3 mGy during this procedure. The patient’s postoperative course was uneventful, and the outcome was favorable. No intracranial tumor was detected on preoperative or postoperative cranial CT . However, the patient did not follow the doctor’s orders for review until 2.5 years after the surgery. The patient was admitted to the hospital with sudden linguistic confusion, left limb immobility, and drowsiness. Urgent cranial MRI and CT revealed a right temporal lobe occupancy with significant displacement of midline structures, brainstem compression, and deformation but no dilatation of the ventricular system, and no enhanced scan was performed . During the examination, the patient’s condition gradually deteriorated, leading to unconsciousness and an inability to answer questions, resulting in a Glasgow coma scale (GCS) score of 6. Additionally, her right pupil diameter was 6 mm, and her left pupil diameter was 3 mm. Bilateral pupillary direct and indirect light responses were absent. The muscle strength of the left limb was grade I, and that of the right limb was grade III. The left Babinski sign was positive. The initial diagnoses were right temporal lobe occupation and brain herniation. The patient’s critical condition necessitated emergency tumor resection via a right enlarged pterygoid approach and decompressive craniectomy under general anesthesia. Intraoperatively, a small portion of tumor tissue bulged through the bone window, but intraoperative ultrasound indicated no blood flow signal, eliminating the possibility of a large intracranial aneurysm. The tumor tissue had an intact thicker envelope after incision, clear borders defined with surrounding brain tissue, and edema of peripheral normal brain tissue. The tumor, measuring approximately 5 × 5 × 5 cm 3 in size, was adherent to the dura mater at the base of the skull and located at the right mid-cranial base. The tumor was resected in chunks, and the adherent basal dura mater was cauterized using bipolar electrocoagulation to prevent remnants of tumor tissue. Brain tissue collapsed after tumor resection, and drains were placed in the cavity, followed by the placement of artificial dura mater and drains outside the dura mater. Because of preoperative brain herniation, the bone flap was no longer retracted, and decompression of the bone flap was performed. The skull was closed layer by layer, and the patient was admitted to the neurosurgery intensive care unit with mannitol and hormones to eliminate cerebral edema and control intracranial pressure. Based on the postoperative physical examination, the patient’s GCS score was 12. The bilateral pupils were equal in size and round but dull to light reflection. The muscle strength of the left limb was grade 3, and that of the right limb was grade 4. The patient’s postoperative CT confirmed that the tumor had been completely resected, with no significant bleeding in the operative area . Histopathological examination confirmed that the right temporal lobe lesion was a meningioma [meningothelial, World Health Organization (WHO) grade I; Figure 4 ]. On the fifth postoperative day, the patient developed fever, lumbar puncture suggested an intracranial pressure of 210 mmH 2 O, and the color of cerebrospinal fluid was slightly yellowish and turbid. Therefore, the possibility of intracranial infection was considered, and the patient was administered meropenem + vancomycin. Physical examination illustrated that the patient’s GCS score was 12, the pupils were equal in size and sensitive to light reflexes, and muscle strength was grade 4 in the left limb and grade 5 in the right limb . On postoperative day 23, the patient’s condition was stable, physical examination revealed a GCS score of 15, and the pupils were equal in size and sensitive to light reflex. The muscle strength of the left limb was grade 4, and that of the right limb was grade 5. MRI revealed that the meningioma had been completely resected . The patient was discharged from the hospital waiting for review with a recommendation for MRI every 3–6 months. Considering the patient’s financial situation, we chose the less expensive CT instead of MRI at the time of the review. Follow-up CT 2 and 5 months after surgery revealed no residual or recurrent tumor , and the patient was able to return to normal activities without epilepsy, visual and auditory disturbances, headaches, or other sequelae.
| 3.904297
| 0.981934
|
sec[1]/p[0]
|
en
| 0.999996
|
39011474
|
https://doi.org/10.3389/fonc.2024.1413610
|
[
"tumor",
"limb",
"grade",
"intracranial",
"that",
"postoperative",
"tissue",
"brain",
"aneurysm",
"score"
] |
[
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
},
{
"code": "ND56.1",
"title": "Open wound of unspecified body region"
},
{
"code": "LB9Z",
"title": "Structural developmental anomalies of the skeleton, unspecified"
},
{
"code": "FB56.6",
"title": "Other specified soft tissue disorders"
},
{
"code": "5B51&XS25",
"title": "Severe wasting in infants, children or adolescents"
},
{
"code": "ND55",
"title": "Other injuries of leg, level unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
[ND56.1] Open wound of unspecified body region
Also known as: Open wound of unspecified body region | cut NOS | open wound NOS | penetrating wound NOS | Puncture wound with foreign body unspecified body region
Excludes: Traumatic amputations involving multiple body regions | Open wounds involving multiple body regions | traumatic amputation NOS
[LB9Z] Structural developmental anomalies of the skeleton, unspecified
Also known as: Structural developmental anomalies of the skeleton, unspecified | Abnormal bone development | skeletal anomaly NOS
[FB56.6] Other specified soft tissue disorders
Also known as: Other specified soft tissue disorders | Fat necrosis | fatty necrosis | Profichet's disease | Sloughing of fascia
[ND55] Other injuries of leg, level unspecified
Also known as: Other injuries of leg, level unspecified | other injuries of lower limb, level unspecified | Superficial injury of leg, level unspecified | Abrasion of leg, level unspecified | Contusion of leg, level unspecified
Excludes: Fracture of leg, level unspecified | Injuries involving multiple body regions
=== GRAPH WALKS ===
--- Walk 1 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--RELATED_TO--> [?] Pathological fracture in neoplastic disease of unknown behaviour
--- Walk 2 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs
--- Walk 3 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--EXCLUDES--> [?] Chronic lymphadenitis
--- Walk 4 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Localised adiposity
Def: A condition characterised by accumulation of adipose tissue in specific regions of the body....
--CHILD--> [?] Fat pad
Def: A condition characterised by a mass of closely packed adipose cells surrounded by fibrous tissue septa. When localised in the heel this condition may present with dull pain when pressure is applied....
--- Walk 5 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system
--- Walk 6 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs
|
[
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --RELATED_TO--> [?] Pathological fracture in neoplastic disease of unknown behaviour",
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --EXCLUDES--> [?] Chronic lymphadenitis",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Localised adiposity\n Def: A condition characterised by accumulation of adipose tissue in specific regions of the body....\n --CHILD--> [?] Fat pad\n Def: A condition characterised by a mass of closely packed adipose cells surrounded by fibrous tissue septa. When localised in the heel this condition may present with dull pain when pressure is applied....",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs"
] |
2F9Z
|
Neoplasms of unknown behaviour of unspecified site
|
[
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2242",
"icd10_title": "Localized swelling, mass and lump, left lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2231",
"icd10_title": "Localized swelling, mass and lump, right upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2241",
"icd10_title": "Localized swelling, mass and lump, right lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2233",
"icd10_title": "Localized swelling, mass and lump, upper limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2243",
"icd10_title": "Localized swelling, mass and lump, lower limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2230",
"icd10_title": "Localized swelling, mass and lump, unspecified upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R220",
"icd10_title": "Localized swelling, mass and lump, head"
}
] |
D487
|
Neoplasm of uncertain behavior of other specified sites
|
An 80-year-woman, who lived alone, had been receiving treatment for myasthenia gravis with tacrolimus at 3.0 mg/day for 2 years. In parallel, the presence of a slowly enlarging anterior mediastinal tumor of 52 mm in diameter (craniocaudal) adjacent to inflammatory changes in the right upper lobe was discovered, for which she was referred to our hospital. Positive acetylcholine receptor antibody pointed to a diagnosis of thymoma, cT1aN0M0 Stage I. Considering the patient’s age, immunodeficient status, and tumor size, we proposed two treatment options: (i) observation, and (ii) extended thymectomy under sternotomy. According to the wishes of the patient and her family, the decision was made to perform extended thymectomy. After switching from tacrolimus to prednisolone (at 7.5 mg/day), extended thymectomy via median sternotomy was performed. Partial resection of the right upper lobe was also performed, because of tumor invasion into that region of the lung. The postoperative course was uneventful. Pathological diagnosis was type B2 thymoma with tumor invasion to the right upper lobe, pT3N0M0 Stage IIIA. Adjuvant local radiotherapy was not done, in consideration of her age and social background. Two months after the operation, skin redness was first observed at the median point, cranial side, of the scar. Levofloxacin was initiated to treat the infection; however, after two weeks, pus was observed at the wound site, which was collected for general bacterial culture. She was admitted and treated with incision and drainage, and tazobactam/piperacillin with the addition of vancomycin. Seven days later, a fever occurred and computed tomography (CT) scans revealed an abscess spreading around the sternal notch to the manubrium, and focal mediastinal thickening . Three sternal wires and the sequestrum of the manubrium were removed. The upper side of the mediastinum was kept open under general anesthesia and, during debridement, pus was drained from the manubrium. Tissue culture from this surgery detected acid-fast bacillus; therefore, the antibiotics were changed to imipenem/cilastatin (IMP/CS) and clarithromycin (CAM). Finally, CAM was replaced with amikacin (AMK) because of the appearance of suspected drug eruption and detection of CAM-resistant M. abscessus in the susceptibility testing, which was proven on day 64 post-onset. Retrospective CT review indicated some inflammatory changes in the bilateral lung; therefore, bronchial lavage culture of the right upper lobe was collected at the 2nd surgery, but was negative. On day 70 post-onset, CT showed ring-enhanced low-density nodules in the bilateral supraclavicular, right axillary, and parasternal regions, indicative of disseminated lesions of M. abscessus infection (lymphadenitis) . The number and deep location of these nodules rendered complete infection control by surgical means difficult; conservative treatment was considered to be a preferable treatment strategy. Negative pressure wound therapy (NPWT) was started on day 91 post-onset. Two slightly enlarged lymph nodes were punctured and drained of pus. Long-term NPWT reduced the wound size, but the infected granulation tissue formation was prolonged after NPWT was ceased. During the treatment course , the culture from the wound and C-reactive protein in the blood became negative. Moreover, the culture of pus from the two punctured lymph nodes was also negative. The decision was made to perform wound closure for the following reasons: (i) negative results of wound culture and inflammation status; (ii) the patient being unable to leave the hospital because of her inability to self-treat the wound at home; and (iii) her wish to have the wound close. Preoperative short tau inversion recovery image magnetic resource imaging (MRI) showed focal high-intensity areas in the sternoclavicular joints, suggesting residual sequestrum; therefore, bilateral clavicle heads and sternum debridement and wound closure with a left pectoralis major flap to fill the space was performed . Pathologically, the debrided tissue showed granulomatous inflammation with necrosis, but its cultures were negative. The antibiotics were changed to orally administered linezolid and clofazimine, and she was discharged 53 days after wound closure (total admission period: 317 days). Although swollen lymph nodes remained on CT, no recurrence was observed 5 months after the antibiotics were completed (total sensitive antibiotics use: 366 days). Fig. 1 A , B Preoperative CT shows anterior mediastinal tumor adjacent to inflammatory changes in right upper lobe (yellow arrowheads). C , D CT before surgical drainage revealed abscess spreading around sternal notch to manubrium, and focal mediastinal thickening Fig. 2 A – C CT shows lymphadenitis in bilateral supraclavicular, right axially, and parasternal lymph nodes (yellow arrowheads). The wound is left open (white arrowheads). D Appearance of the wound before wound closure. E Intraoperative findings. Left pectoralis major flap was used for wound closure to fill the space Fig. 3 Detailed treatment course. AMK amikacin, CAM clarithromycin, CLF clofazimine, IMP/CS imipenem/cilastatin, LN lymph node, LZD , linezolid
| 4.003906
| 0.977539
|
sec[1]/p[0]
|
en
| 0.999997
|
37599318
|
https://doi.org/10.1186/s40792-023-01730-8
|
[
"wound",
"culture",
"tumor",
"lobe",
"lymph",
"closure",
"mediastinal",
"manubrium",
"antibiotics",
"nodes"
] |
[
{
"code": "MD11.5",
"title": "Dyspnoea"
},
{
"code": "NB32.3Z",
"title": "Injury of lung, unspecified"
},
{
"code": "NB91.1Z",
"title": "Injury of liver, unspecified"
},
{
"code": "NA01.Z&XA9T94",
"title": "Temporal wound"
},
{
"code": "ND56.1",
"title": "Open wound of unspecified body region"
},
{
"code": "QE00",
"title": "Acculturation difficulty"
},
{
"code": "MD40.51",
"title": "Positive sputum culture"
},
{
"code": "MD40.52",
"title": "Positive throat culture"
},
{
"code": "QE0Z",
"title": "Problems associated with social or cultural environment, unspecified"
},
{
"code": "MG65",
"title": "Abnormal microbiological findings in specimens from other organs, systems and tissues"
}
] |
=== ICD-11 CODES FOUND ===
[MD11.5] Dyspnoea
Definition: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a presenting complaint of patients with a wide variety of medical diseases by multiple mechanisms.
Dyspnoea is considered acute when it lasts from hours up to 3 weeks, subacute from 3 weeks up to 8 weeks, and chronic dyspnoea lasts more than 8 weeks.
Also known as: Dyspnoea | difficulty breathing | respiration difficult | short of breath | winded
Includes: Orthopnoea
Excludes: Transient tachypnoea of newborn
[NB32.3Z] Injury of lung, unspecified
Also known as: Injury of lung, unspecified | Certain injuries of lung | injury of lung NOS | acute lung injury NOS | lung wound NOS
[NB91.1Z] Injury of liver, unspecified
Also known as: Injury of liver, unspecified | Injury of liver | liver wound NOS | liver fracture NOS | hepatocellular injury
[ND56.1] Open wound of unspecified body region
Also known as: Open wound of unspecified body region | cut NOS | open wound NOS | penetrating wound NOS | Puncture wound with foreign body unspecified body region
Excludes: Traumatic amputations involving multiple body regions | Open wounds involving multiple body regions | traumatic amputation NOS
[QE00] Acculturation difficulty
Definition: Problems resulting from the inability to adjust to a different culture or environment.
Also known as: Acculturation difficulty | acculturation problem | cultural shock | social migrant difficulty | migration
Excludes: Disorders specifically associated with stress
[MD40.51] Positive sputum culture
Also known as: Positive sputum culture
[MD40.52] Positive throat culture
Also known as: Positive throat culture
[QE0Z] Problems associated with social or cultural environment, unspecified
Also known as: Problems associated with social or cultural environment, unspecified | social environment problem
[MG65] Abnormal microbiological findings in specimens from other organs, systems and tissues
Also known as: Abnormal microbiological findings in specimens from other organs, systems and tissues | positive wound culture | Positive culture findings on specimen from other organs, systems and tissue
=== GRAPH WALKS ===
--- Walk 1 ---
[MD11.5] Dyspnoea
Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...
--EXCLUDES--> [?] Transient tachypnoea of newborn
Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....
--PARENT--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 2 ---
[MD11.5] Dyspnoea
Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...
--EXCLUDES--> [?] Transient tachypnoea of newborn
Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....
--PARENT--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 3 ---
[NB32.3Z] Injury of lung, unspecified
--PARENT--> [NB32.3] Certain injuries of lung
--CHILD--> [NB32.30] Contusion of lung
--- Walk 4 ---
[NB32.3Z] Injury of lung, unspecified
--PARENT--> [NB32.3] Certain injuries of lung
--CHILD--> [NB32.30] Contusion of lung
--- Walk 5 ---
[NB91.1Z] Injury of liver, unspecified
--PARENT--> [NB91.1] Injury of liver
Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....
--CHILD--> [NB91.12] Laceration of liver, moderate
--- Walk 6 ---
[NB91.1Z] Injury of liver, unspecified
--PARENT--> [NB91.1] Injury of liver
Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....
--RELATED_TO--> [?] Birth injury to liver
Def: Rupture or subcapsular haemorrhage into the liver parenchyma as a result of birth trauma usually seen in large for gestational age infants, those with hepatomegaly, those born by breech delivery; may ...
|
[
"[MD11.5] Dyspnoea\n Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...\n --EXCLUDES--> [?] Transient tachypnoea of newborn\n Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....\n --PARENT--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[MD11.5] Dyspnoea\n Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...\n --EXCLUDES--> [?] Transient tachypnoea of newborn\n Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....\n --PARENT--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[NB32.3Z] Injury of lung, unspecified\n --PARENT--> [NB32.3] Certain injuries of lung\n --CHILD--> [NB32.30] Contusion of lung",
"[NB32.3Z] Injury of lung, unspecified\n --PARENT--> [NB32.3] Certain injuries of lung\n --CHILD--> [NB32.30] Contusion of lung",
"[NB91.1Z] Injury of liver, unspecified\n --PARENT--> [NB91.1] Injury of liver\n Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....\n --CHILD--> [NB91.12] Laceration of liver, moderate",
"[NB91.1Z] Injury of liver, unspecified\n --PARENT--> [NB91.1] Injury of liver\n Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....\n --RELATED_TO--> [?] Birth injury to liver\n Def: Rupture or subcapsular haemorrhage into the liver parenchyma as a result of birth trauma usually seen in large for gestational age infants, those with hepatomegaly, those born by breech delivery; may ..."
] |
MD11.5
|
Dyspnoea
|
[
{
"from_icd11": "MD11.5",
"icd10_code": "R0603",
"icd10_title": "Acute respiratory distress"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0601",
"icd10_title": "Orthopnea"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0602",
"icd10_title": "Shortness of breath"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0600",
"icd10_title": "Dyspnea, unspecified"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0609",
"icd10_title": "Other forms of dyspnea"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R060",
"icd10_title": "Dyspnea"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27321A",
"icd10_title": "Contusion of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27322A",
"icd10_title": "Contusion of lung, bilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27331S",
"icd10_title": "Laceration of lung, unilateral, sequela"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27331A",
"icd10_title": "Laceration of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27329A",
"icd10_title": "Contusion of lung, unspecified, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27339A",
"icd10_title": "Laceration of lung, unspecified, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27391A",
"icd10_title": "Other injuries of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27391S",
"icd10_title": "Other injuries of lung, unilateral, sequela"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27321D",
"icd10_title": "Contusion of lung, unilateral, subsequent encounter"
}
] |
R0603
|
Acute respiratory distress
|
Initial plain radiographs demonstrated in all cases a solitary, expansile, lytic lesion involving the epiphysis and extending up to the articular surface of the distal radius (n = 4) or ulna (n = 1). The physis was fused in all patients. Four lesions were graded as Campanacci grade 2 (active). These showed eccentric expansion of bone with associated cortical thinning but no cortical de-struction or pathologic fracture . One lesion was graded as Campanacci grade 3 (aggressive) with cortical breach of the radial styloid articular surface . MRI showed expansile subarticular lesions returning low to isointense signal relative to surrounding muscle on T1-weighted imaging and heterogeneous predominantly high STIR and T2-weighted signal intensity . Gadolinium was administered in three cases and demonstrated diffuse enhancement in all cases. There were fluid–fluid levels in one patient indicative of secondary aneurysmal bone cyst change . There was a focal breach of the radial styloid articular surface with a small amount of soft-tissue extending into the radial aspect of the carpal joint in the Campanacci grade 3 lesion. In the remaining cases, the articular surface appeared intact. PET/CT revealed lytic, expansile lesions without a sclerotic rim and marked cortical thinning with an increased standardized uptake value (SUV) in all cases . The average pre-treatment SUV was 14.8 (Table 1 ). There were no distant lesions and the lungs were clear in all patients. Fig. 1 Patient 1: pre denosumab, a frontal plain radiograph shows a lytic Campanacci grade 2 distal radial GCTB with mild expansion and cortical thinning (arrow). Post denosumab at 2 months, b frontal plain radiograph demonstrates sclerosis of the tumour margin (arrows) and radial articular surface. There is mild modeling deformity of the radial articular surface and moderate internal matrix osteosclerosis. Post surgical, c frontal plain radiograph 1 week post surgical curettage, cementoplasty and internal fixation shows lucency of the peripheral tumour cavity (arrows) and d 2 years post surgery with progressive infilling of the lesion with osteosclerosis around the cement despite no post operative denosumab therapy (arrows) Fig. 2 Patient 2: pre denosumab, a frontal plain radiograph shows a lytic Campanacci grade 2 distal radial GCTB with medial expansion and cortical thinning (arrow). b Sagittal T2-weighted MR image demonstrates volar expansion and fluid fluid levels (arrows) indicating secondary aneurysmal bone cyst. Post denosumab at 2 months, c frontal plain radiograph demonstrates more clearly defined sclerotic tumour margins particularly along the expansile medial aspect of the lesion (arrows) and mild matrix osteosclerosis Fig. 3 Patient 3: pre denosumab, a frontal plain radiograph demonstrates a Campanacci grade 2 distal ulnar GCTB with mild expansion and cortical thinning. b Axial T2-weighted fat saturated and c axial T1-weighted MR images confirm an expansile heterogeneous predominantly high T2- and low to isointense T1-weighted distal ulnar lesion ( U ulnar, R radius). Post denosumab at 2 months, d frontal plain radiograph shows marginal sclerosis and internal matrix sclerosis, with mild modeling deformity of the ulnar articular surface (black arrow). e Axial T2-weighted fat saturated and f axial T1-weighted MR images show definition of cortical margins with the formation of marginal sclerosis seen as peripheral low T1 and T2-W signal (white arrows). The tumour matrix is more heterogeneous with areas of low T2-W signal reflecting internal matrix consolidation ( R radius) Fig. 4 Patient 4: pre denosumab, a frontal plain radiograph demonstrates a lytic expansile Campanacci grade 2 distal radial GCTB with cortical thinning. b Coronal STIR MR image shows the lesion returns heterogeneous predominantly high STIR MR signal. c Fused PET/CT image illustrates marked FDG uptake with a standardized uptake value (SUV) of 17 (arrow). Post denosumab at 2 months, d coronal STIR MR image shows increased heterogeneity of MR signal with areas of low STIR signal reflecting matrix osteosclerosis (white arrows). e Fused PET/CT image confirms a significant decrease in FDG uptake with an SUV of 4.8 and the formation of marginal sclerosis (red arrows) Fig. 5 Patient 5: pre denosumab, a frontal plain radiograph illustrates a distal radial GCTB with moderate expansion and cortical thinning. A breach of the radial styloid articular surface (arrow) with soft tissue extending into the carpal joint was confirmed on MR imaging and this lesion was graded as Campanacci grade 3. b Fused PET/CT image confirms marked metabolic activity with an increased SUV of 19.5 (arrow). Post denosumab at 2 months, c frontal plain radiograph demonstrates an increase in size of the lesion despite marginal sclerosis with reconstitution of the radial articular surface (arrow) and quite marked intralesional matrix consolidation. d Fused PET/CT image confirms reduced activity of the lesion with a significant decrease in the SUV to 4.5 (arrow). Post surgical, e frontal plain radiograph 2 months post surgery shows tumour recurrence with rapid growth, progressive bone destruction and extrusion of cement (arrow)
| 4.1875
| 0.505859
|
sec[2]/sec[0]/sec[1]/p[0]
|
en
| 0.999996
|
29214010
|
https://doi.org/10.1186/s13569-017-0085-3
|
[
"plain",
"radial",
"denosumab",
"frontal",
"radiograph",
"lesion",
"cortical",
"articular",
"surface",
"arrow"
] |
[
{
"code": "LB99.2",
"title": "Radial hemimelia"
},
{
"code": "8C10.2",
"title": "Lesion of radial nerve"
},
{
"code": "BD30.00&XA8RG5",
"title": "Radial artery embolism"
},
{
"code": "BD30.01&XA8RG5",
"title": "Radial artery thrombosis"
},
{
"code": "NC34.2",
"title": "Injury of radial nerve at forearm level"
},
{
"code": "9C82.4",
"title": "Oculomotor apraxia"
},
{
"code": "CA0A.Y&XA91G8",
"title": "Frontal sinus fistula"
},
{
"code": "CA0J.Y&XA91G8",
"title": "Polyp of frontal sinus"
},
{
"code": "NA02.14",
"title": "Fracture of frontal sinus of skull"
},
{
"code": "CA0C&XA91G8",
"title": "Cyst of frontal sinus"
}
] |
=== ICD-11 CODES FOUND ===
[LB99.2] Radial hemimelia
Definition: Radial hemimelia is a congenital longitudinal deficiency of the radius bone of the forearm characterised by partial or total absence of the radius.
Also known as: Radial hemimelia | Longitudinal reduction defect of radius | agenesis of radial ray | agenesis of radius | congenital absence of radius
Includes: Radial clubhand
[8C10.2] Lesion of radial nerve
Also known as: Lesion of radial nerve | radial nerve mononeuritis | Superficial radial nerve lesion | Radial nerve posterior interosseous syndrome | Radial nerve paralysis
Excludes: Injury of radial nerve at upper arm level | Injury of radial nerve at forearm level | Injury of radial nerve at wrist or hand level
[NC34.2] Injury of radial nerve at forearm level
Also known as: Injury of radial nerve at forearm level | injury of radial nerve NOS | Laceration of radial nerve at forearm level
[9C82.4] Oculomotor apraxia
Also known as: Oculomotor apraxia | Congenital ocular motor apraxia | Cogan’s congenital ocular motor apraxia | Saccadic palsy | Head thrust movement
[NA02.14] Fracture of frontal sinus of skull
Also known as: Fracture of frontal sinus of skull | fracture of frontal sinus | frontal sinus bone fracture
=== GRAPH WALKS ===
--- Walk 1 ---
[LB99.2] Radial hemimelia
Def: Radial hemimelia is a congenital longitudinal deficiency of the radius bone of the forearm characterised by partial or total absence of the radius....
--PARENT--> [LB99] Reduction defects of upper limb
Def: Any condition caused by the failure of an upper limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....
--CHILD--> [LB99.1] Humeral agenesis or hypoplasia
--- Walk 2 ---
[LB99.2] Radial hemimelia
Def: Radial hemimelia is a congenital longitudinal deficiency of the radius bone of the forearm characterised by partial or total absence of the radius....
--PARENT--> [LB99] Reduction defects of upper limb
Def: Any condition caused by the failure of an upper limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....
--CHILD--> [LB99.1] Humeral agenesis or hypoplasia
--- Walk 3 ---
[8C10.2] Lesion of radial nerve
--EXCLUDES--> [?] Injury of radial nerve at wrist or hand level
--CHILD--> [?] Injury of radial nerve of wrist
--- Walk 4 ---
[8C10.2] Lesion of radial nerve
--EXCLUDES--> [?] Injury of radial nerve at forearm level
--PARENT--> [?] Injury of nerves at forearm level
--- Walk 5 ---
[NC34.2] Injury of radial nerve at forearm level
--PARENT--> [NC34] Injury of nerves at forearm level
--CHILD--> [NC34.1] Injury of median nerve at forearm level
--- Walk 6 ---
[NC34.2] Injury of radial nerve at forearm level
--PARENT--> [NC34] Injury of nerves at forearm level
--CHILD--> [NC34.1] Injury of median nerve at forearm level
|
[
"[LB99.2] Radial hemimelia\n Def: Radial hemimelia is a congenital longitudinal deficiency of the radius bone of the forearm characterised by partial or total absence of the radius....\n --PARENT--> [LB99] Reduction defects of upper limb\n Def: Any condition caused by the failure of an upper limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....\n --CHILD--> [LB99.1] Humeral agenesis or hypoplasia",
"[LB99.2] Radial hemimelia\n Def: Radial hemimelia is a congenital longitudinal deficiency of the radius bone of the forearm characterised by partial or total absence of the radius....\n --PARENT--> [LB99] Reduction defects of upper limb\n Def: Any condition caused by the failure of an upper limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....\n --CHILD--> [LB99.1] Humeral agenesis or hypoplasia",
"[8C10.2] Lesion of radial nerve\n --EXCLUDES--> [?] Injury of radial nerve at wrist or hand level\n --CHILD--> [?] Injury of radial nerve of wrist",
"[8C10.2] Lesion of radial nerve\n --EXCLUDES--> [?] Injury of radial nerve at forearm level\n --PARENT--> [?] Injury of nerves at forearm level",
"[NC34.2] Injury of radial nerve at forearm level\n --PARENT--> [NC34] Injury of nerves at forearm level\n --CHILD--> [NC34.1] Injury of median nerve at forearm level",
"[NC34.2] Injury of radial nerve at forearm level\n --PARENT--> [NC34] Injury of nerves at forearm level\n --CHILD--> [NC34.1] Injury of median nerve at forearm level"
] |
LB99.2
|
Radial hemimelia
|
[
{
"from_icd11": "LB99.2",
"icd10_code": "Q714",
"icd10_title": "Longitudinal reduction defect of radius"
},
{
"from_icd11": "8C10.2",
"icd10_code": "G5632",
"icd10_title": "Lesion of radial nerve, left upper limb"
},
{
"from_icd11": "8C10.2",
"icd10_code": "G5631",
"icd10_title": "Lesion of radial nerve, right upper limb"
},
{
"from_icd11": "8C10.2",
"icd10_code": "G5630",
"icd10_title": "Lesion of radial nerve, unspecified upper limb"
},
{
"from_icd11": "8C10.2",
"icd10_code": "G563",
"icd10_title": "Lesion of radial nerve"
},
{
"from_icd11": "NC34.2",
"icd10_code": "S5421XA",
"icd10_title": "Injury of radial nerve at forearm level, right arm, initial encounter"
},
{
"from_icd11": "NC34.2",
"icd10_code": "S5422XA",
"icd10_title": "Injury of radial nerve at forearm level, left arm, initial encounter"
},
{
"from_icd11": "NC34.2",
"icd10_code": "S5420XA",
"icd10_title": "Injury of radial nerve at forearm level, unspecified arm, initial encounter"
},
{
"from_icd11": "NC34.2",
"icd10_code": "S542",
"icd10_title": "Injury of radial nerve at forearm level"
},
{
"from_icd11": "9C82.4",
"icd10_code": "H518",
"icd10_title": "Other specified disorders of binocular movement"
}
] |
Q714
|
Longitudinal reduction defect of radius
|
The patient was a 70-year-old male patient with a history of hypertension who was transferred to the emergency department of our hospital on 5 April 2022 (the 13th day after vaccination, denoted as “D13”) due to neck and shoulder pain accompanied by numbness and fatigue for 12 days. He was admitted to the intensive care unit (ICU) of our hospital on 9 April. The patient had the cold symptoms of nasal stuffiness and discharge, sneezing, sore throat, and cough before vaccination, and nasal congestion symptoms on the day of vaccination, but no other symptoms. The patient suddenly developed severe neck and shoulder pain 12 days after receiving the third dose of COVID-19 vaccine while cold symptoms were not completely gone on 23 March 2022. He went to a local hospital and was diagnosed with “periarthritis of shoulder”. In the evening, he began to develop weakness and numbness of limbs, accompanied by mobility disorder and inability to walk, accompanied by headache and dizziness, without nausea and vomiting. Symptomatic treatment was given, but the symptoms did not alleviate significantly and became progressively worse, so he was transferred to a local superior hospital. Laboratory blood samples taken on 29 March 2022 (6 days after vaccination, similarly denoted as “D6”) showed amounts of white blood cells (WBC) at 12.1 × 10 9 /L, neutrophil count percent (NEUT%) at 89.2%, procalcitonin (PCT) at 0.45 ng/mL, C-reactive protein (CRP) at 100.0 mg/L, and erythrocyte sedimentation rate (ESR) at 53 mm/h ( Table 1 ). Cervical X-ray at 6 days after vaccination (D6) showed straightening of cervical curvature and hyperosteogeny . Plain CT scan of cervical spine showed hyperosteogeny of cervical spine and slight herniation of C3/4, C4/5, and C5/6 intervertebral discs . Cervical MRI plain scan showed cervical instability, spinal cord degeneration at C3 to C6 vertebral body level, backward disc herniation at C3/4, C4/5, C5/6, and C6/7, and spinal canal stenosis at C6/7 level . During the hospitalization, the weakness of the limbs gradually worsened, and the patient developed paralysis of the lower extremities and hypoesthesia on 1 April 2022 (D9). Fever occurred once, with a body temperature of 38.6 ℃ accompanied by chills, and there was no fever since then. The diagnosis of the local hospital considered the possibility of cervical vertebra infection, and meropenem and vancomycin were combined to fight infection, but the symptoms were not significantly relieved. For further treatment, the patient was transferred to the emergency department of our hospital. The patient developed spontaneous illness with poor energy, appetite, and sleep. Physical examination: low breath sound in both lungs, no obvious subcutaneous mass in neck, and no sinus or ulceration in skin. The physiological lordosis of the cervical spine disappeared and the movement was significantly limited. There was obvious tenderness in spinous processes and paraspinal muscles from C3 to C6, radiating pain in both upper arms, shoulders and back. The sensation below the line plane of both nipples decreased significantly. Muscle strength: left upper limb is grade 1, right upper limb is grade 1+, lower limb is grade 0. Muscle tension: both upper limbs decreased significantly, both lower limbs disappeared. Bilateral Chaddock signs were positive, but both cervical resistance and bilateral Babinski signs were negative. Laboratory blood samples taken on 5 April 2022 (D13) showed amounts of WBC at 14.1 × 10 9 /L, NEUT% at 85.5%, PCT at 0.16 ng/mL, and ESR at 67 mm/h ( Table 1 ). Imaging examination: Cervical X-ray films at 15 days after vaccination (D15) in our hospital suggested possible intervertebral lesions of C5/6 and C6/7 . Plain CT scan of the cervical spine and lung revealed increased density in the right margin of the C5 and C6 vertebrae: nature undetermined, C2/3 and C3/4 discs slightly protruded backwards . MRI plain scan of cervical spine reveals abnormal signals in the spinal cord at the level of C3 to C6 vertebrae, compressive changes, and abnormal signals in C5 vertebrae, abnormal signals and flattening in C5/6 intervertebral discs: infectious lesions? . Cervical abscess, cervical spinal cord injury, and paraplegia were considered for cervical CT and MRI examination. The patient had cervical abscess compression on the spinal cord and was indicated for surgery. He was temporarily given anti-infection treatment of imipenem, cilastatin, and levofloxacin, and was transferred to ICU for intensive care and waiting for surgery. Laboratory test results on 9 April 2022 (D17) showed amounts of WBC at 7.8 × 10 9 /L, NEUT% at 74.9%, PCT at 0.30 ng/mL, and CRP at 93.3 mg/L ( Table 1 ). The patient did not have symptoms such as low fever and night sweats, and all indicators related to tuberculosis infection were negative, so the possibility of tuberculosis infection was considered to be low. The COVID-19 nucleic acid tests were negative before the third vaccination and during hospitalization. Combined with the patient’s symptoms, signs, and auxiliary examination results, the possibility of suppurative infection is considered to be high for cervical bone destruction at present.
| 3.910156
| 0.981445
|
sec[1]/p[0]
|
en
| 0.999997
|
PMC9415974
|
https://doi.org/10.3390/vaccines10081276
|
[
"cervical",
"vaccination",
"infection",
"both",
"april",
"significantly",
"spine",
"spinal",
"transferred",
"accompanied"
] |
[
{
"code": "GA04",
"title": "Cervicitis"
},
{
"code": "GA1Z&XA5WW1",
"title": "Noninflammatory disorders of cervix uteri"
},
{
"code": "FB1Y",
"title": "Other specified conditions associated with the spine"
},
{
"code": "GA04&XT5R",
"title": "Acute cervicitis"
},
{
"code": "GA04&XT8W",
"title": "Chronic cervicitis"
},
{
"code": "NE60",
"title": "Harmful effects of drugs, medicaments or biological substances, not elsewhere classified"
},
{
"code": "QC02.Z",
"title": "Need for immunization against certain specified single infectious diseases, unspecified"
},
{
"code": "QC04.Z",
"title": "Immunization not carried out for unspecified reason"
},
{
"code": "NE80.3",
"title": "Other serum reactions"
},
{
"code": "QC01.8",
"title": "Need for immunization against influenza"
}
] |
=== ICD-11 CODES FOUND ===
[GA04] Cervicitis
Also known as: Cervicitis | inflammation of cervix | inflammation of cervix uteri | Ulcer of cervix with cervicitis | Acute cervicitis
[FB1Y] Other specified conditions associated with the spine
Also known as: Other specified conditions associated with the spine | Other recurrent vertebral subluxation | Interspinous ligament syndrome | Spondylitis muscularis | Posterior longitudinal ligament calcification
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
Also known as: Harmful effects of drugs, medicaments or biological substances, not elsewhere classified | drugs, medicaments or biological substances, toxicity not elsewhere classified | adverse drug effects | drug reaction NOS | drug allergy NOS
Excludes: Alcohol intoxication | pathological drug intoxication | hypersensitivity reaction to correctly administered drug
[QC02.Z] Need for immunization against certain specified single infectious diseases, unspecified
Also known as: Need for immunization against certain specified single infectious diseases, unspecified | Need for immunization against certain specified single infectious diseases | Need for immunization against unspecified infectious disease | immunization | prophylactic vaccination
[QC04.Z] Immunization not carried out for unspecified reason
Also known as: Immunization not carried out for unspecified reason | Immunization not carried out | vaccination not done | Immunization not carried out because of contraindication, not otherwise specified
[NE80.3] Other serum reactions
Also known as: Other serum reactions | Allergic reaction to serum | serum allergy | Complications of vaccination, protein sickness | Protein sickness
Excludes: serum hepatitis
[QC01.8] Need for immunization against influenza
Also known as: Need for immunization against influenza | influenza vaccination | prophylactic vaccination against influenza
=== GRAPH WALKS ===
--- Walk 1 ---
[GA04] Cervicitis
--RELATED_TO--> [?] Tuberculosis of cervix uteri
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is of the cervix uteri....
--PARENT--> [?] Tuberculosis of female reproductive organs
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is of the female reproductive organs....
--- Walk 2 ---
[GA04] Cervicitis
--PARENT--> [?] Inflammatory disorders of the female genital tract
--RELATED_TO--> [?] Adenomyosis
Def: A condition of the uterus characterised by endometrial tissue growth in the myometrium, hypertrophy of the myometrium, and heavy or prolonged menstrual bleeding, dysmenorrhoea, dyspareunia, bleeding b...
--- Walk 3 ---
[FB1Y] Other specified conditions associated with the spine
--PARENT--> [?] Conditions associated with the spine
Def: This is a group of conditions in which there is a deviation from or interruption of the normal structure or function of the spine....
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--- Walk 4 ---
[FB1Y] Other specified conditions associated with the spine
--PARENT--> [?] Conditions associated with the spine
Def: This is a group of conditions in which there is a deviation from or interruption of the normal structure or function of the spine....
--RELATED_TO--> [?] Spinal pain
Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine....
|
[
"[GA04] Cervicitis\n --RELATED_TO--> [?] Tuberculosis of cervix uteri\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is of the cervix uteri....\n --PARENT--> [?] Tuberculosis of female reproductive organs\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is of the female reproductive organs....",
"[GA04] Cervicitis\n --PARENT--> [?] Inflammatory disorders of the female genital tract\n --RELATED_TO--> [?] Adenomyosis\n Def: A condition of the uterus characterised by endometrial tissue growth in the myometrium, hypertrophy of the myometrium, and heavy or prolonged menstrual bleeding, dysmenorrhoea, dyspareunia, bleeding b...",
"[FB1Y] Other specified conditions associated with the spine\n --PARENT--> [?] Conditions associated with the spine\n Def: This is a group of conditions in which there is a deviation from or interruption of the normal structure or function of the spine....\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....",
"[FB1Y] Other specified conditions associated with the spine\n --PARENT--> [?] Conditions associated with the spine\n Def: This is a group of conditions in which there is a deviation from or interruption of the normal structure or function of the spine....\n --RELATED_TO--> [?] Spinal pain\n Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine...."
] |
GA04
|
Cervicitis
|
[
{
"from_icd11": "FB1Y",
"icd10_code": "M5126",
"icd10_title": "Other intervertebral disc displacement, lumbar region"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95A",
"icd10_title": "Adverse effect of other bacterial vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z15A",
"icd10_title": "Adverse effect of immunoglobulin, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z95A",
"icd10_title": "Adverse effect of other vaccines and biological substances, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95S",
"icd10_title": "Adverse effect of other bacterial vaccines, sequela"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B95A",
"icd10_title": "Adverse effect of other viral vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A25A",
"icd10_title": "Adverse effect of mixed bacterial vaccines without a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A91A",
"icd10_title": "Poisoning by other bacterial vaccines, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T498X5A",
"icd10_title": "Adverse effect of other topical agents, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48905A",
"icd10_title": "Adverse effect of unspecified agents primarily acting on the respiratory system, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48995A",
"icd10_title": "Adverse effect of other agents primarily acting on the respiratory system, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A15A",
"icd10_title": "Adverse effect of pertussis vaccine, including combinations with a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B15A",
"icd10_title": "Adverse effect of smallpox vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T416X3A",
"icd10_title": ""
},
{
"from_icd11": "NE60",
"icd10_code": "T419X3A",
"icd10_title": ""
}
] |
M5126
|
Other intervertebral disc displacement, lumbar region
|
The proband, a male born to consanguineous parents (first cousins) of Arab descent, was born after pregnancy with polyhydramnios and delivered at term, weighing 2,900 g and his length was 45 cm. Both parents were healthy; paternal height was 170 cm and maternal height 160 cm. There was one healthy brother of normal stature. There was no family history of short stature, hypothyroidism, deafness, or neurological impairment. In the first week of life, the proband had recurrent vomiting and prolonged neonatal jaundice with indirect hyperbilirubinemia of 15 mg/dL that resolved spontaneously. At age 6 months, severe failure to thrive and dehydration were diagnosed, resulting in hospital admission. Delayed psychomotor development, growth retardation, and dysmorphic facial features were noted. On physical examination, he had enlarged fontanelle, severe hypotonia, umbilical hernia, and dry skin consistent clinically with hypothyroidism. Laboratory evaluation revealed low TSH (0.08 mIU/L; normal range 0.27–4.2) and free thyroxine (FT 4 ) (5.4 pmol/L; normal range 12–22), indicating central hypothyroidism. Further investigation demonstrated mild bilateral frontal and interhemispheric cortical atrophy (on brain computed tomography (CT) scan and sensorineural (SN) hearing loss (Brainstem Auditory Evoked Response test). Comprehensive metabolic investigations were normal, as were echocardiography and ophthalmic examination. The karyotype was 46, XY, and no chromosomal abnormalities were identified. LT 4 treatment was initiated at a dose of 30 μg daily, but was discontinued by the parents after 2 months. At the age of 4 years, he was diagnosed with severe mental retardation and was fully disabled. At 5 years of age, the proband presented to a different Endocrine clinic for investigation of severe growth retardation. At that time, TSH was 0.01 mU/L, FT 4 1.34 pmol/L and FT 3 < 0.44 nmol/L (normal range 1.3–3.1). Thyrotropin-releasing hormone (TRH) test confirmed the diagnosis of central hypothyroidism ( Table 1 ) and LT 4 therapy was recommended. In addition, insulin growth factor-1 (IGF-1) and insulin growth factor binding protein-3 (IGFBP-3) levels were undetectable with no GH response to arginine stimulation test ( Table 1 ). Unfortunately, although the family was informed on several occasions as to the importance of supplemental LT4 therapy and the need for GH treatment, compliance remained poor and the family failed to attend follow-up appointments so GH therapy was not initiated. The patient was seen for the first time in our Pediatric Endocrine clinic when he presented at age 17.5 years for evaluation of extreme short stature. At that time, his appearance resembled that of a 2-year-old child. His height was 81.7 cm (−9.3 SD) and weight 11.5 kg (−9.3 SD). He had dysmorphic facial features with a deep nasal bridge, a prominent forehead, micrognathia, flat nose, big, prominent auricles, multiple preauricular skin tags, and widely spaced teeth . He had acromicria and a prominent abdomen without organomegaly. His pubertal stage was Tanner 1 with testicular volume of 2 mL bilaterally. Severe neurodevelopmental delay was noted, with general hypotonia; he was unable to stand unsupported. He was deaf and mute, communicating with sign language at a basic level. Investigations revealed a bone age of 8.5 years (at chronological age 17.5 years), undetectable TSH, FT 4 3.8 pmol/L, PRL < 8 mIU/L (normal range 45–375), IGF-1 < 3.25 ng/mL, and IGFBP-3 < 500 ng/mL. Cortisol and adrenocorticotropic hormone (ACTH) levels were within normal limits and gonadotropin levels were pre-pubertal ( Table 1 ). As previous investigations were unavailable at that time, the diagnoses of central hypothyroidism and GHD were reconfirmed by stimulation tests. Brain MRI demonstrated a hypoplastic anterior pituitary, a normally located posterior pituitary bright spot, white matter demyelination and cervicomedullary kinking. Biochemistry, celiac screen, and complete blood count were within normal limits. LT 4 therapy was recommenced with dose adjusted to maintain FT 4 within a normal range. GH therapy was initiated with dose adjusted to weight (0.03 mg/kg per day) and growth velocity. Gonadotropin-releasing hormone (GnRH) analog treatment (3.75 mg every 28 days) was initiated at the onset of puberty (Tanner P2, G2, age 21 years) to facilitate maximal linear growth. Calcium supplement and vitamin D 3 were added due to low serum levels of vitamin D. In addition, physiotherapy and speech therapy were implemented. At the age of 24 years, growth velocity decreased to <2 cm per year and therefore GH and GnRH analog therapy were terminated. At 28 years of age, height had increased by 42.3 cm (+3 SD) to a final adult height of 124 cm , and weight was 28 kg (−7.5 SD). Pubertal stage Tanner P5 was attained with testicular volume of 15 mL bilaterally. Considerable improvement in tone and psychomotor function was observed consequent to implementation of appropriate therapy; he learned to stand independently, walk several steps unsupported, and communicate vocally with family and medical staff. Overall, he had a happier demeanor, but unfortunately remained non-verbal.
| 4.160156
| 0.963867
|
sec[1]/p[0]
|
en
| 0.999998
|
31316460
|
https://doi.org/10.3389/fendo.2019.00381
|
[
"growth",
"height",
"hypothyroidism",
"that",
"range",
"family",
"initiated",
"time",
"proband",
"parents"
] |
[
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "MG44.1Z",
"title": "Lack of expected normal physiological development, unspecified"
},
{
"code": "5A61.3",
"title": "Growth hormone deficiency"
},
{
"code": "8C7Y",
"title": "Other specified primary disorders of muscles"
},
{
"code": "FB86.Z",
"title": "Disorders associated with bone growth, unspecified"
},
{
"code": "PG51",
"title": "Fall or jump of undetermined intent from a height of 1 metre or more"
},
{
"code": "6B03",
"title": "Specific phobia"
},
{
"code": "PG5Z",
"title": "Fall or jump of undetermined intent, height unspecified"
},
{
"code": "PA6Z",
"title": "Unintentional fall from unspecified height"
},
{
"code": "PA60",
"title": "Unintentional fall on the same level or from less than 1 metre"
}
] |
=== ICD-11 CODES FOUND ===
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[MG44.1Z] Lack of expected normal physiological development, unspecified
Also known as: Lack of expected normal physiological development, unspecified | Lack of expected normal physiological development | delayed physiological development | unspecified delay in development | development arrest
[5A61.3] Growth hormone deficiency
Definition: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficiency. Includes idiopathic, inborn and acquired forms of growth hormone deficiency.
Also known as: Growth hormone deficiency
Excludes: Hypopituitarism
[8C7Y] Other specified primary disorders of muscles
Also known as: Other specified primary disorders of muscles | Certain specified primary disorders of muscles | Myopathy due to calsequestrin or SERCA1 protein overload | Delayed muscle maturation | delayed muscle growth
[FB86.Z] Disorders associated with bone growth, unspecified
Also known as: Disorders associated with bone growth, unspecified | Disorders associated with bone growth
[PG51] Fall or jump of undetermined intent from a height of 1 metre or more
Also known as: Fall or jump of undetermined intent from a height of 1 metre or more | jumped from height NOS | Fall or jump of undetermined intent from ladder or scaffolding equipment | Fall or jump of undetermined intent from building or structure | Fall or jump of undetermined intent from tree
[6B03] Specific phobia
Definition: Specific phobia is characterised by a marked and excessive fear or anxiety that consistently occurs upon exposure or anticipation of exposure to one or more specific objects or situations (e.g., proximity to certain animals, flying, heights, closed spaces, sight of blood or injury) that is out of proportion to actual danger. The phobic objects or situations are avoided or else endured with intense fear or anxiety. Symptoms persist for at least several months and are sufficiently severe to result
Also known as: Specific phobia | Simple phobia | isolated phobia | Acarophobia | Acrophobia
Includes: Simple phobia
Excludes: Body dysmorphic disorder | Hypochondriasis
[PG5Z] Fall or jump of undetermined intent, height unspecified
Also known as: Fall or jump of undetermined intent, height unspecified | fall from height NOS | Falling, jumping or pushed from a high place, undetermined intent | victim falling from one level to another, undetermined intent
[PA6Z] Unintentional fall from unspecified height
Also known as: Unintentional fall from unspecified height | fall NOS | accidental fall | fall causing injury that resulted in death | fell NOS
[PA60] Unintentional fall on the same level or from less than 1 metre
Also known as: Unintentional fall on the same level or from less than 1 metre | ground level fall | fell while ambulating | fall from standing height | fall from standing position
Excludes: Fall in health care | Fall while in hospital | Fall from hospital bed
=== GRAPH WALKS ===
--- Walk 1 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F90] Neoplasms of unknown behaviour of oral cavity or digestive organs
--- Walk 2 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--PARENT--> [02] Neoplasms
Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....
--- Walk 3 ---
[MG44.1Z] Lack of expected normal physiological development, unspecified
--PARENT--> [MG44.1] Lack of expected normal physiological development
Def: Lack of expected normal physiological development includes delayed milestone of development and other lack of expected normal physiological development including gross and fine motor development, lang...
--EXCLUDES--> [?] Delayed puberty
Def: This is when an organism has passed the usual age of onset of puberty with no physical or hormonal signs that it is beginning. Puberty may be delayed for several years and still occur normally, in whi...
--- Walk 4 ---
[MG44.1Z] Lack of expected normal physiological development, unspecified
--PARENT--> [MG44.1] Lack of expected normal physiological development
Def: Lack of expected normal physiological development includes delayed milestone of development and other lack of expected normal physiological development including gross and fine motor development, lang...
--EXCLUDES--> [?] Disorders of intellectual development
Def: Disorders of intellectual development are a group of etiologically diverse conditions originating during the developmental period characterised by significantly below average intellectual functioning ...
--- Walk 5 ---
[5A61.3] Growth hormone deficiency
Def: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficienc...
--EXCLUDES--> [?] Hypopituitarism
Def: A disorder manifesting a deficiency or decrease of one or more pituitary hormones, which is caused by a variety of diseases such as tumour, trauma/surgery, irradiation, inflammation and haemorrhage/in...
--CHILD--> [?] Acquired hypopituitarism
Def: This is the acquired decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain....
--- Walk 6 ---
[5A61.3] Growth hormone deficiency
Def: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficienc...
--PARENT--> [5A61] Hypofunction or certain other specified disorders of pituitary gland
Def: Clinical status with disordered function of the pituitary gland without excessive pituitary hormone production, which is caused by a variety of diseases...
--RELATED_TO--> [?] Non-secreting pituitary adenoma
|
[
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F90] Neoplasms of unknown behaviour of oral cavity or digestive organs",
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --PARENT--> [02] Neoplasms\n Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....",
"[MG44.1Z] Lack of expected normal physiological development, unspecified\n --PARENT--> [MG44.1] Lack of expected normal physiological development\n Def: Lack of expected normal physiological development includes delayed milestone of development and other lack of expected normal physiological development including gross and fine motor development, lang...\n --EXCLUDES--> [?] Delayed puberty\n Def: This is when an organism has passed the usual age of onset of puberty with no physical or hormonal signs that it is beginning. Puberty may be delayed for several years and still occur normally, in whi...",
"[MG44.1Z] Lack of expected normal physiological development, unspecified\n --PARENT--> [MG44.1] Lack of expected normal physiological development\n Def: Lack of expected normal physiological development includes delayed milestone of development and other lack of expected normal physiological development including gross and fine motor development, lang...\n --EXCLUDES--> [?] Disorders of intellectual development\n Def: Disorders of intellectual development are a group of etiologically diverse conditions originating during the developmental period characterised by significantly below average intellectual functioning ...",
"[5A61.3] Growth hormone deficiency\n Def: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficienc...\n --EXCLUDES--> [?] Hypopituitarism\n Def: A disorder manifesting a deficiency or decrease of one or more pituitary hormones, which is caused by a variety of diseases such as tumour, trauma/surgery, irradiation, inflammation and haemorrhage/in...\n --CHILD--> [?] Acquired hypopituitarism\n Def: This is the acquired decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain....",
"[5A61.3] Growth hormone deficiency\n Def: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficienc...\n --PARENT--> [5A61] Hypofunction or certain other specified disorders of pituitary gland\n Def: Clinical status with disordered function of the pituitary gland without excessive pituitary hormone production, which is caused by a variety of diseases...\n --RELATED_TO--> [?] Non-secreting pituitary adenoma"
] |
2F9Z
|
Neoplasms of unknown behaviour of unspecified site
|
[
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R6250",
"icd10_title": "Unspecified lack of expected normal physiological development in childhood"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R6259",
"icd10_title": "Other lack of expected normal physiological development in childhood"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R6251",
"icd10_title": "Failure to thrive (child)"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R6252",
"icd10_title": "Short stature (child)"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R62",
"icd10_title": "Lack of expected normal physiological development in childhood and adults"
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R628",
"icd10_title": ""
},
{
"from_icd11": "MG44.1Z",
"icd10_code": "R629",
"icd10_title": ""
},
{
"from_icd11": "FB86.Z",
"icd10_code": "M89761",
"icd10_title": "Major osseous defect, right lower leg"
},
{
"from_icd11": "FB86.Z",
"icd10_code": "M89772",
"icd10_title": "Major osseous defect, left ankle and foot"
}
] |
D487
|
Neoplasm of uncertain behavior of other specified sites
|
A 48-year-old woman presented with a two-year history of persistent head pressure and dizziness. She awoke one day with the symptoms. She had no prior headache history. She described her symptoms as holocranial pressure with some pain along with persistent lightheadedness. She would also experience true episodes of intermittent vertigo. She did not recognize a triggering event for her headaches. She did have some migraine-associated symptoms with exacerbations of head pressure including nausea, photophobia, and phonophobia. She had consulted with multiple physicians without a true diagnosis or effective treatment. There was some consideration for vestibular migraine, but migraine preventives (topiramate, valproic acid, and nortriptyline) were ineffective. Prior imaging demonstrated a partial empty sella, with no Chiari malformation or tonsillar ectopia. She had no vessel imaging studies. Past medical history was significant for noninsulin-dependent type II diabetes mellitus and hyperlipidemia. Her BMI was slightly elevated at 28. Neurologic examination was nonfocal including no disc edema on fundus evaluation. Her head pressure, however, worsened in the Trendelenburg position (10 degree head-down tilt). MR angiography and venography were completed and were normal. Formal neuro-ophthalmologic evaluation was normal with no evidence of disc edema. She was started on acetazolamide and did extremely well with almost complete alleviation of all of her symptoms at a dose of 1,125 mg per day of the short-acting formulation. She was given a diagnosis of new daily persistent headache (NDPH) based on the International Classification of Headache Disorders criteria as her headache/pressure symptoms began one day out of the blue and lasted for longer than 3 months . The underlying etiology was hypothesized to be an abnormal reset of CSF pressure/volume to an elevated state because of her worsening in the Trendelenburg position (which rapidly increases intracranial CSF pressure within seconds of head-down tilt) and her response to CSF pressure/volume-lowering medications. This subtype of NDPH has been previously described by one of the authors (TDR) . After trying to switch her to the extended release formulation of acetazolamide, she lost control of her headaches/head pressure. A lumbar puncture (LP) was carried out on a semiemergent basis, and thus, she was still on a tapering dose of short-acting acetazolamide (750 mg) at the time of the procedure. The LP was completed to help establish if CSF pressure/volume was indeed the cause of her head pressure syndrome and to hopefully alleviate her symptom exacerbation. Opening pressure in the prone position was 23 cm of H 2 O, and closing pressure was 15 cm H 2 O after 15 mL of CSF was removed. CSF analysis was negative. The patient felt immediately better after the LP, but a day after, she developed an orthostatic headache which did not respond to conservative measures including tapering off the acetazolamide. An epidural blood patch alleviated the post-LP headache, but this seemed to reset her CSF pressure high again as she was back to daily head pressure/pain and dizziness. Her opening pressure fell within the new guidelines of normal, but she was on acetazolamide at the time of the LP, and she improved with CSF removal . Eventually, she stabilized again on chronic acetazolamide therapy (1,125 mg per day) and did well for one year. She then had a second exacerbation of head pressure that was unresponsive to an increased dosing of her medication. Therapeutic LP was arranged. One day prior to her LP, she acutely stopped acetazolamide on her own volition. Opening pressure was 22 cm H 2 O, and closing pressure was 13 cm H 2 O after 15 cc of CSF was removed. The patient felt remarkably better after the procedure. Her only neurologic symptom was a two-hour episode of facial numbness and contralateral hemibody numbness which occurred two days after the LP. She did not develop a post-LP headache. Her CSF analysis demonstrated no evidence of inflammation with only one nucleated cell and a normal total protein and glucose level. Her Gram stain and bacterial and fungal cultures were also negative. A brain MRI was completed 16 days after the LP to look for any secondary causes for her worsening head pressure, and this demonstrated a cytotoxic edematous lesion in the splenium of the corpus callosum (Figures 1(a) – 1(c) ). Laboratory studies (CBC and basic metabolic panel) were normal at the time of neuroimaging. Serum cytokine levels were not obtained. No additional neurologic testing (such as an EEG) was deemed necessary as the patient was having no neurologic symptoms at the time of the MRI, and her neurologic examination was normal. She clinically was still much improved in regard to her head pressure. Repeat imaging 2 weeks later noted near-to-complete resolution of the lesion (Figures 1(d) and 1(e) ). In retrospect, it would have been helpful to obtain serum cytokine levels at the time of the abnormal MRI imaging to see if they were elevated. However, measuring cytokine levels in the CSF would have been even more sensitive to look for alterations within the central nervous system.
| 4.078125
| 0.974121
|
sec[1]/p[0]
|
en
| 0.999996
|
33149954
|
https://doi.org/10.1155/2020/8849645
|
[
"pressure",
"head",
"headache",
"acetazolamide",
"neurologic",
"time",
"imaging",
"persistent",
"migraine",
"including"
] |
[
{
"code": "EH90.Z",
"title": "Pressure ulcer of unspecified grade"
},
{
"code": "MB23.L",
"title": "Pressured speech"
},
{
"code": "MD30.Z",
"title": "Chest pain, unspecified"
},
{
"code": "CB22.Y",
"title": "Other specified diseases of mediastinum, not elsewhere classified"
},
{
"code": "BA2Z",
"title": "Hypotension, unspecified"
},
{
"code": "NA63",
"title": "Traumatic amputation at neck level"
},
{
"code": "MB4D",
"title": "Headache, not elsewhere classified"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "MB48.3",
"title": "Light-headedness"
},
{
"code": "FB3Z",
"title": "Disorders of muscles, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[EH90.Z] Pressure ulcer of unspecified grade
Also known as: Pressure ulcer of unspecified grade | Pressure ulceration | pressure injury | pressure ulcer | decubitus ulcer
[MB23.L] Pressured speech
Definition: Speech in which the person feels undue pressure to get the words out. The person’s speech is usually rapid, loud, and emphatic and may be difficult or impossible to interrupt. Frequently, the person talks without any social stimulation and may continue to talk even though no one is listening.
Also known as: Pressured speech
Excludes: Schizophrenia or other primary psychotic disorders | Bipolar or related disorders
[MD30.Z] Chest pain, unspecified
Also known as: Chest pain, unspecified | Pain in throat or chest | chest pain NOS | pain in chest | chest pressure
[CB22.Y] Other specified diseases of mediastinum, not elsewhere classified
Also known as: Other specified diseases of mediastinum, not elsewhere classified | Hernia of mediastinum | mediastinal hernia | mediastinal herniation | Infectious mediastinitis
[BA2Z] Hypotension, unspecified
Also known as: Hypotension, unspecified | hypopiesis | low blood pressure | arterial hypotension NOS | decreased blood pressure
[NA63] Traumatic amputation at neck level
Also known as: Traumatic amputation at neck level | complete head avulsion | Decapitation | decapitation of head at neck level | severed head
Includes: Decapitation
[MB4D] Headache, not elsewhere classified
Definition: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above.
Also known as: Headache, not elsewhere classified | cephalalgia | cephalgia | cephalodynia | pain in head NOS
Excludes: Trigeminal neuralgia | Atypical facial pain | Acute headache, not elsewhere classified
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[MB48.3] Light-headedness
Also known as: Light-headedness | light headed
[FB3Z] Disorders of muscles, unspecified
Also known as: Disorders of muscles, unspecified | disorder of muscle, unspecified | muscle disease | muscular disease | muscular disorder
=== GRAPH WALKS ===
--- Walk 1 ---
[EH90.Z] Pressure ulcer of unspecified grade
--PARENT--> [EH90] Pressure ulceration
Def: Pressure ulcers result from localised injury and ischaemic necrosis of skin and underlying tissues due to prolonged pressure, or pressure in combination with shear; bony prominences of the body are th...
--CHILD--> [EH90.1] Pressure ulceration grade 2
Def: Pressure injury with partial thickness loss of dermis. It presents as a shallow open ulcer with a red or pink wound bed without slough or as a serum-filled or serosanguinous blister which may rupture....
--- Walk 2 ---
[EH90.Z] Pressure ulcer of unspecified grade
--PARENT--> [EH90] Pressure ulceration
Def: Pressure ulcers result from localised injury and ischaemic necrosis of skin and underlying tissues due to prolonged pressure, or pressure in combination with shear; bony prominences of the body are th...
--CHILD--> [EH90.2] Pressure ulceration grade 3
Def: Pressure ulcer with full thickness skin loss. Subcutaneous fat may be visible but bone, tendon or muscle are not exposed. Slough may be present but does not obscure the depth of tissue loss. There may...
--- Walk 3 ---
[MB23.L] Pressured speech
Def: Speech in which the person feels undue pressure to get the words out. The person’s speech is usually rapid, loud, and emphatic and may be difficult or impossible to interrupt. Frequently, the person t...
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.2] Avoidance behaviour
Def: The act of keeping away from circumstances, situations, or stimuli that cause anxiety or other negative emotions in the individual....
--- Walk 4 ---
[MB23.L] Pressured speech
Def: Speech in which the person feels undue pressure to get the words out. The person’s speech is usually rapid, loud, and emphatic and may be difficult or impossible to interrupt. Frequently, the person t...
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--- Walk 5 ---
[MD30.Z] Chest pain, unspecified
--PARENT--> [MD30] Pain in throat or chest
Def: Pain in throat and chest means having pain sensation in throat or chest. Throat is a tube that carries food to oesophagus and air to windpipe and larynx. The technical name for throat is pharynx....
--CHILD--> [MD30.Z] Chest pain, unspecified
--- Walk 6 ---
[MD30.Z] Chest pain, unspecified
--PARENT--> [MD30] Pain in throat or chest
Def: Pain in throat and chest means having pain sensation in throat or chest. Throat is a tube that carries food to oesophagus and air to windpipe and larynx. The technical name for throat is pharynx....
--EXCLUDES--> [?] Acute pharyngitis
Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o...
|
[
"[EH90.Z] Pressure ulcer of unspecified grade\n --PARENT--> [EH90] Pressure ulceration\n Def: Pressure ulcers result from localised injury and ischaemic necrosis of skin and underlying tissues due to prolonged pressure, or pressure in combination with shear; bony prominences of the body are th...\n --CHILD--> [EH90.1] Pressure ulceration grade 2\n Def: Pressure injury with partial thickness loss of dermis. It presents as a shallow open ulcer with a red or pink wound bed without slough or as a serum-filled or serosanguinous blister which may rupture....",
"[EH90.Z] Pressure ulcer of unspecified grade\n --PARENT--> [EH90] Pressure ulceration\n Def: Pressure ulcers result from localised injury and ischaemic necrosis of skin and underlying tissues due to prolonged pressure, or pressure in combination with shear; bony prominences of the body are th...\n --CHILD--> [EH90.2] Pressure ulceration grade 3\n Def: Pressure ulcer with full thickness skin loss. Subcutaneous fat may be visible but bone, tendon or muscle are not exposed. Slough may be present but does not obscure the depth of tissue loss. There may...",
"[MB23.L] Pressured speech\n Def: Speech in which the person feels undue pressure to get the words out. The person’s speech is usually rapid, loud, and emphatic and may be difficult or impossible to interrupt. Frequently, the person t...\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.2] Avoidance behaviour\n Def: The act of keeping away from circumstances, situations, or stimuli that cause anxiety or other negative emotions in the individual....",
"[MB23.L] Pressured speech\n Def: Speech in which the person feels undue pressure to get the words out. The person’s speech is usually rapid, loud, and emphatic and may be difficult or impossible to interrupt. Frequently, the person t...\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....",
"[MD30.Z] Chest pain, unspecified\n --PARENT--> [MD30] Pain in throat or chest\n Def: Pain in throat and chest means having pain sensation in throat or chest. Throat is a tube that carries food to oesophagus and air to windpipe and larynx. The technical name for throat is pharynx....\n --CHILD--> [MD30.Z] Chest pain, unspecified",
"[MD30.Z] Chest pain, unspecified\n --PARENT--> [MD30] Pain in throat or chest\n Def: Pain in throat and chest means having pain sensation in throat or chest. Throat is a tube that carries food to oesophagus and air to windpipe and larynx. The technical name for throat is pharynx....\n --EXCLUDES--> [?] Acute pharyngitis\n Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o..."
] |
EH90.Z
|
Pressure ulcer of unspecified grade
|
[
{
"from_icd11": "EH90.Z",
"icd10_code": "L89623",
"icd10_title": "Pressure ulcer of left heel, stage 3"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89621",
"icd10_title": "Pressure ulcer of left heel, stage 1"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89899",
"icd10_title": "Pressure ulcer of other site, unspecified stage"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89620",
"icd10_title": "Pressure ulcer of left heel, unstageable"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89622",
"icd10_title": "Pressure ulcer of left heel, stage 2"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89892",
"icd10_title": "Pressure ulcer of other site, stage 2"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89519",
"icd10_title": "Pressure ulcer of right ankle, unspecified stage"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89891",
"icd10_title": "Pressure ulcer of other site, stage 1"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89610",
"icd10_title": "Pressure ulcer of right heel, unstageable"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89893",
"icd10_title": "Pressure ulcer of other site, stage 3"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89890",
"icd10_title": "Pressure ulcer of other site, unstageable"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89629",
"icd10_title": "Pressure ulcer of left heel, unspecified stage"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89619",
"icd10_title": "Pressure ulcer of right heel, unspecified stage"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L8945",
"icd10_title": "Pressure ulcer of contiguous site of back, buttock and hip, unstageable"
},
{
"from_icd11": "EH90.Z",
"icd10_code": "L89894",
"icd10_title": "Pressure ulcer of other site, stage 4"
}
] |
L89623
|
Pressure ulcer of left heel, stage 3
|
In the next 12 h after the deterioration, the patient was stabilized with a balanced electrolyte solution (Sterofundin® ISO, B.Braun, Melsungen AG, DE) for treatment of hypovolemia as needed, tranexamic acid (20 mg/kg every 6–8 h,Cyklokapron®, Pfizer, Puurs, BE), two units of fresh frozen plasma (FFP) as well as packed red blood cells (15 ml/kg pRBCs). Also, a chest tube was placed, and the thorax was drained. Approximately 12 h after catheter removal, the breathing pattern of the patient was further deteriorating, and her neck and head started to swell up. Worsening of the hypercapnia resulted in severe respiratory acidosis (see Table 1 ) and the decision was made to induce general anesthesia (premedication with midazolam 0.2 mg/kg iv, Midazolam-hameln 5 mg/ml, Hameln, DE, induction with propofol 4 mg/kg iv, Propofol Hexal 10 mg/ml, Holzkirchen, DE, maintenance with fentanyl CRI 2.5 – 5μq/kg/h, Fentadon, Dechra Veterinary Products, Aulendorf, DE, midazolam CRI: 0.1 – 0.2 mg/kg/h and later pentobarbital CRI 0.2 – 2 mg/kg/h, Narcoren 16 g/100 ml, Vetmedica GmbH, Ingelheim, DE, for a total of 14 h) and ventilate (Siemens Maquet SERVO – S, Rastatt, DE) with pressure-controlled ventilation. The patient also received a surgically placed tracheostomy tube for the time she remained on the ventilator. The same morning that the mechanical ventilation was started, further stabilization of the hematocrit with one unit of whole blood (16 ml/kg WB) from donors of the same blood type after compatible cross-matching was performed. Over these first 12 h, 1,300 ml of pleural effusion were drained. The fluid was serosanguineous with a PCV of 5% and a relatively low total nucleated cell count (TNCC 2.64 ×10 3 μl). A total of 150 ml was reinfused after washing and processing with an autotransfusion device (OrthoPat, Haemonetics, Braintree MA, USA). The head and neck swelling further worsened, and moderate hypoalbuminemia (21.1 g/l, range: 29.6 – 37.01 g/l) was detected. As an attempt to increase oncotic pressure and to decrease the edema formation, a total of 40 g of human serum albumin 20% (CSL Behring GmbH, Marburg, DE; 0.5 ml/kg/h over 16 h) was administrated. One day after these stabilization measures, clinical and laboratory values improved. At the echocardiography, a mild amount of thrombotic material was suspected in the right atrium. Two days after the incident and to prevent further thrombus formation, and enoxaparin CRI was started, initially at a low dose of 1.5 mg/kg/day. Anti-factor Xa was measured regularly to avoid overzealous anticoagulation and prevent further bleeding. The values with that dosage after 24 and 48 h were 0.19 and 0.47 IU, which lie below the recommended reference range for thromboprophylaxis in the literature (0.5 – 1.0) ( 12 ). The following days the dog remained under mild sedation (fentanyl CRI: 2.5 – 5 μg/kg/h for 1 day, and the next 5 days with butorphanol CRI: 0.1 – 0.2 mg/kg/h, and if needed acepromazine: 0.01 – 0.02 mg/kg iv, Prequilan 10 mg/ml, Fatro SpA, IT) on the ventilator mainly on PSV mode (Pressure Support Ventilation) alternating with CPAP mode (Continuous Positive Airway Pressure). This support seemed to be necessary to overcome the tracheal compression induced by the mediastinal hematoma formation. The duration of time without ventilator support could be increased from day to day. On the 7th day on the mechanical ventilator, the inflammation parameters in the blood increased, the aspirate out of the endotracheal tube suction became purulent, and the patient's oxygenation levels dropped slightly. The development of ventilator-associated pneumonia was strongly suspected. Blood and tracheal aspirate cultures were taken and revealed growth of multi-resistant bacteria ( E.coli and A.baumanii ). The patient was already receiving amoxicillin-clavulanic acid, 20 mg/kg iv every 8 h, (AmoxClav Hexal 500/100 mg, Hexal, Holzkirchen, DE) as one concern was that leptospirosis could also be responsible for the acute kidney failure. So, another antibiotic drug, marbofloxacin, 2 mg/kg iv and later orally, Marbocyl FD 1%, Vetoquinol, Ismaning, DE, was administered when symptoms started. Clinical improvement of the patient and decrease of the inflammatory markers could be observed. Further cultures of blood and urine before discharge yielded no bacterial growth. The dog was weaned from the ventilator after 8 days. The tracheostomy tube was removed after 12 days. The progression of the hematoma shrinking to its disappearance is visualized in Figures 2B–D . An echocardiography on the 21st day of hospitalization revealed no thrombotic material. A schematic presentation of the case management can be seen in Figure 3 . The kidney values were within the normal range at the time of hospital discharge and remained normal until today (2 years after presentation). Three months after discharge the urine specific gravity was 1.026, the blood pressure and the SDMA concentration were slightly elevated (SDMA: 16 μg/dl, range: 0 – 14 μg/dl) and the dog was staged at that time as IRIS Stage 1 borderline hypertensive, not proteinuric. Nine months after discharge, the SDMA concentration was normal (14 μg/dl).
| 3.933594
| 0.961426
|
sec[1]/p[3]
|
en
| 0.999995
|
34291102
|
https://doi.org/10.3389/fvets.2021.691472
|
[
"blood",
"ventilator",
"pressure",
"tube",
"total",
"time",
"that",
"range",
"midazolam",
"hexal"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "MD11.Y",
"title": "Other specified abnormalities of breathing"
},
{
"code": "MD11.7",
"title": "Hyperventilation"
},
{
"code": "PK81.0",
"title": "Ventilation associated with injury or harm in therapeutic use"
},
{
"code": "QB41",
"title": "Dependence on respirator"
},
{
"code": "CA70.7",
"title": "Air conditioner or humidifier lung"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[MD11.Y] Other specified abnormalities of breathing
Also known as: Other specified abnormalities of breathing | Bradypnoea | Choking sensation | Hypoventilation | hypoventilation syndrome NOS
[MD11.7] Hyperventilation
Definition: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the normal range of 37 to 43 mm Hg. Hyperventilation should be distinguished from tachypnoea, an increase in respiratory frequency, and from hyperpnea, an increase in minute volume of ventilation.
Also known as: Hyperventilation | hyperventilating | overbreathing | HV - [hyperventilation] | increased respiratory rate
[PK81.0] Ventilation associated with injury or harm in therapeutic use
Also known as: Ventilation associated with injury or harm in therapeutic use | complication during or following ventilation | Ventilator associated pneumonia | VAP - [ventilator associated pneumonia] | respirator associated pneumonia
Excludes: Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
[QB41] Dependence on respirator
Also known as: Dependence on respirator | dependence on iron lung | dependence on respiratory ventilator
[CA70.7] Air conditioner or humidifier lung
Definition: A form of the sick building syndrome caused by organisms that contaminate humidifiers and the piping of air conditioner ducts. The air conditioner blows cold air containing spores of the organisms throughout the building.
Also known as: Air conditioner or humidifier lung | air conditioner lung | air humidifier pneumonitis | humidifier lung | sauna takers lung
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--CHILD--> [?] Diseases of spleen
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Diseases of the immune system
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.4Z] Haematuria, unspecified
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--EXCLUDES--> [?] Recurrent or persistent glomerular haematuria
Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --CHILD--> [?] Diseases of spleen",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Diseases of the immune system",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.4Z] Haematuria, unspecified",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --EXCLUDES--> [?] Recurrent or persistent glomerular haematuria\n Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
An otherwise healthy 5-year-old kindergarten Japanese boy presented to an emergency department of a community hospital with a 4-day history of the left anterior knee pain, the onset of which occurred while crawling and kneeling in doors. About 1 week earlier, he had sustained a skin abrasion on the anterior aspect of the left knee after a ground level fall. There was localized redness and mild swelling of the anterior knee and dull pain with extreme flexion. Radiographs demonstrated no lytic lesion in the anterior aspect of the patella. He was diagnosed with acute bacterial cellulitis and treated with an orally active third generation cephalosporin. Two day later, he was referred to another community hospital because of persisting symptoms and the occurrence of limping. Computed tomography (CT) showed soft-tissue swelling of the anterior knee, which was interpreted as septic prepatellar bursitis associated with cellulitis, but, in retrospect, exhibited a slight indentation in the ventral aspect of the cartilaginous patella . Although oral antibiotic was changed to ampicillin with β-lactamase inhibitor because of suspicion of gram-negative bacterial infections, resting knee pain was further exacerbated. It was not until 2 weeks after the onset of pain that he was started on intravenous antibiotics, with ampicillin and sulbactam administered for 1 day, and then ceftriaxone for 7 days. Magnetic resonance imaging (MRI) showed a focal destructive change of the ventral half of the cartilaginous patella and a suprapatellar joint effusion . Blood culture drawn at the time of referral was negative whereas subsequent culture from the bursal fluid aspirate grew PA, suggesting acute purulent Pseudomonas patellar osteomyelitis. He thus underwent urgent debridement of the patella. A longitudinal incision was made over the patella. A subcutaneous abscess was exposed ventral to the patella and thoroughly irrigated. Curettes were used to remove intracartilaginous necrotic tissues of the patella . The purulent synovial fluid was then evacuated using a vertical incision of the suprapatellar pouch, through which open synovectomy of the patellofemoral joint was performed with forceps and curettes. The incision was irrigated and closed after 2 drainage tubes were placed in the pouch . Continuous closed irrigation of the pouch with normal saline was initiated by application of negative pressure suction to one of the tubes. He was transitioned to intravenous meropenem hydrate immediately after the debridement based on culture sensitivities. Cultures taken from the synovial tissues also grew PA. he was made non weight bearing. He continued to have increased white blood cell counts and C-reactive protein values despite surgical debridement with appropriate antibiotic therapy. A follow-up MRI was obtained, which depicted enlargement of the destructive change of the patella and new onset of popliteal effusions . He underwent the second debridement the next day. The prior incision was reopened. Gross purulence of the patella was identified and thoroughly cleaned . The pouch was irrigated and debrided through the original incision. A second incision was unperformed posteriorly. Postoperatively, continuous closed irrigation of the pouch with normal saline was resumed. Four days later, laboratory evaluation showed an elevated C-reactive protein (CRP) value of 96.9 mg/L and a decreased white blood cell (WBC) count of 2800/μL, and he had a body temperature above 38 °C, suggestive of severe infection. At 6 weeks after the onset, he was transferred to our institution for tertiary care because of uncontrollable infection after debridement twice. On admission, antibiotics therapy was supervised by the infection control team (ICT), and he was started on intravenous ceftazidime empirically. According to the ICT’s recommendations, continuous irrigation was discontinued and the affected limb was immobilized with a splint for comfort. Although a rebound in CRP above 40 mg/L and body temperature above 38 °C was observed 3 weeks after the referral, MRI revealed no progression of cartilaginous destruction of the patella and reduced fluid collections. No bony lesions were seen in the distal femur and the proximal tibia . Afterward CRP started to a rapid normalization, descending to <1 mg/L in 1 week, followed by a gradual descent of erythrocyte sedimentation rate (ESR) . At 5 weeks after the referral, staged range of motion and weight-bearing exercises of the affected limb was commenced. MRI delineated surrounding edema of the quadriceps tendon and the infrapatellar fat pad . He completed a 6-week course of intravenous ceftazidime 1 g 3 times a day. He was not transitioned to oral antibiotics. He was hospitalized for 8 weeks and was discharged walking unaided. No recurrence of swelling, warmth, and tender of the left distal thigh was observed at regular clinical follow-up. Three years after the initial surgery, he still has a slight limitation in both flexion and extension of the left knee. Radiographs demonstrated 1.5 cm of leg length discrepancy owing to overgrowth of the distal end of the affected femur and aberrant ossification of the patella .
| 3.916016
| 0.97998
|
sec[1]/p[0]
|
en
| 0.999998
|
36800616
|
https://doi.org/10.1097/MD.0000000000033012
|
[
"patella",
"knee",
"incision",
"debridement",
"pouch",
"pain",
"onset",
"which",
"intravenous",
"aspect"
] |
[
{
"code": "FA32.Z",
"title": "Disorders of patella, unspecified"
},
{
"code": "LB9Z",
"title": "Structural developmental anomalies of the skeleton, unspecified"
},
{
"code": "FA32.Y",
"title": "Other specified disorders of patella"
},
{
"code": "NC93.7",
"title": "Strain or sprain of other or unspecified parts of knee"
},
{
"code": "LB9Y",
"title": "Other specified structural developmental anomalies of the skeleton"
},
{
"code": "FA2Z",
"title": "Inflammatory arthropathies, unspecified"
},
{
"code": "NC90.Y",
"title": "Other specified superficial injury of knee or lower leg"
},
{
"code": "FA34.4",
"title": "Ankylosis of joint"
},
{
"code": "FA33.4Z",
"title": "Chronic instability of knee, unspecified"
},
{
"code": "NC90.0",
"title": "Abrasion of knee"
}
] |
=== ICD-11 CODES FOUND ===
[FA32.Z] Disorders of patella, unspecified
Also known as: Disorders of patella, unspecified | Disorders of patella | disorder of patella | disease of patella | deformity of patella
[LB9Z] Structural developmental anomalies of the skeleton, unspecified
Also known as: Structural developmental anomalies of the skeleton, unspecified | Abnormal bone development | skeletal anomaly NOS
[FA32.Y] Other specified disorders of patella
Also known as: Other specified disorders of patella | Plica syndrome | Slipped patella
[NC93.7] Strain or sprain of other or unspecified parts of knee
Definition: A collective term for muscle and ligament injuries of other and unspecified tissues associated with the knee without dislocation or fracture; a joint injury in which some of the fibers of a supporting ligament are ruptured but the continuity of the ligament remains intact. A strain is an overstretching or overexertion of some part of the musculature.
Also known as: Strain or sprain of other or unspecified parts of knee | Sprain of meniscus of knee | Sprained patella | Strained patella | Sprain of semilunar cartilage of knee
Excludes: sprain of patellar ligament
[LB9Y] Other specified structural developmental anomalies of the skeleton
Also known as: Other specified structural developmental anomalies of the skeleton | Limb hypoplasia or limb reduction defects | hypoplastic extremities | Congenital joint dislocations | Congenital anomalies of patella
[FA2Z] Inflammatory arthropathies, unspecified
Also known as: Inflammatory arthropathies, unspecified | polyarthritis NOS | inflammatory joint disease NOS | nonpyogenic arthritis NOS | arthritic nodosa
[NC90.Y] Other specified superficial injury of knee or lower leg
Also known as: Other specified superficial injury of knee or lower leg | Nonthermal blister of other or unspecified parts of lower leg | Nonvenomous insect bite of other or unspecified parts of lower leg | Superficial foreign body in other or unspecified parts of lower leg | Splinter in other or unspecified parts of lower leg
[FA34.4] Ankylosis of joint
Definition: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition.
Also known as: Ankylosis of joint | ankylosis | ankylosis of joint, site unspecified | frozen joint | fusion of joint
Excludes: stiffness of joint without ankylosis | Ankylosis of spinal joint
[FA33.4Z] Chronic instability of knee, unspecified
Also known as: Chronic instability of knee, unspecified | Chronic instability of knee | instability of knee | old disruption of ligament of knee
[NC90.0] Abrasion of knee
Also known as: Abrasion of knee
=== GRAPH WALKS ===
--- Walk 1 ---
[FA32.Z] Disorders of patella, unspecified
--PARENT--> [FA32] Disorders of patella
--CHILD--> [FA32.0] Recurrent instability of patella
--- Walk 2 ---
[FA32.Z] Disorders of patella, unspecified
--PARENT--> [FA32] Disorders of patella
--PARENT--> [?] Certain specified joint disorders or deformities of limbs
--- Walk 3 ---
[LB9Z] Structural developmental anomalies of the skeleton, unspecified
--PARENT--> [?] Structural developmental anomalies of the skeleton
Def: A deformation established before birth of an anatomical structure of one or more bones....
--CHILD--> [LB72] Structural developmental anomalies of shoulder girdle
Def: Any condition caused by failure of the shoulder girdle to correctly develop during the antenatal period....
--- Walk 4 ---
[LB9Z] Structural developmental anomalies of the skeleton, unspecified
--PARENT--> [?] Structural developmental anomalies of the skeleton
Def: A deformation established before birth of an anatomical structure of one or more bones....
--CHILD--> [LB72] Structural developmental anomalies of shoulder girdle
Def: Any condition caused by failure of the shoulder girdle to correctly develop during the antenatal period....
--- Walk 5 ---
[FA32.Y] Other specified disorders of patella
--PARENT--> [FA32] Disorders of patella
--CHILD--> [FA32.1] Patellofemoral disorders
--- Walk 6 ---
[FA32.Y] Other specified disorders of patella
--PARENT--> [FA32] Disorders of patella
--EXCLUDES--> [?] Dislocation of patella
Def: Displacement of the patella from the femoral groove....
|
[
"[FA32.Z] Disorders of patella, unspecified\n --PARENT--> [FA32] Disorders of patella\n --CHILD--> [FA32.0] Recurrent instability of patella",
"[FA32.Z] Disorders of patella, unspecified\n --PARENT--> [FA32] Disorders of patella\n --PARENT--> [?] Certain specified joint disorders or deformities of limbs",
"[LB9Z] Structural developmental anomalies of the skeleton, unspecified\n --PARENT--> [?] Structural developmental anomalies of the skeleton\n Def: A deformation established before birth of an anatomical structure of one or more bones....\n --CHILD--> [LB72] Structural developmental anomalies of shoulder girdle\n Def: Any condition caused by failure of the shoulder girdle to correctly develop during the antenatal period....",
"[LB9Z] Structural developmental anomalies of the skeleton, unspecified\n --PARENT--> [?] Structural developmental anomalies of the skeleton\n Def: A deformation established before birth of an anatomical structure of one or more bones....\n --CHILD--> [LB72] Structural developmental anomalies of shoulder girdle\n Def: Any condition caused by failure of the shoulder girdle to correctly develop during the antenatal period....",
"[FA32.Y] Other specified disorders of patella\n --PARENT--> [FA32] Disorders of patella\n --CHILD--> [FA32.1] Patellofemoral disorders",
"[FA32.Y] Other specified disorders of patella\n --PARENT--> [FA32] Disorders of patella\n --EXCLUDES--> [?] Dislocation of patella\n Def: Displacement of the patella from the femoral groove...."
] |
FA32.Z
|
Disorders of patella, unspecified
|
[
{
"from_icd11": "FA32.Z",
"icd10_code": "M228X2",
"icd10_title": "Other disorders of patella, left knee"
},
{
"from_icd11": "FA32.Z",
"icd10_code": "M228X1",
"icd10_title": "Other disorders of patella, right knee"
},
{
"from_icd11": "FA32.Z",
"icd10_code": "M22",
"icd10_title": "Disorder of patella"
},
{
"from_icd11": "FA32.Z",
"icd10_code": "M223",
"icd10_title": "Other derangements of patella"
},
{
"from_icd11": "FA32.Z",
"icd10_code": "M228",
"icd10_title": "Other disorders of patella"
},
{
"from_icd11": "FA32.Z",
"icd10_code": "M229",
"icd10_title": "Unspecified disorder of patella"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q8789",
"icd10_title": "Other specified congenital malformation syndromes, not elsewhere classified"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q8781",
"icd10_title": "Alport syndrome"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q742",
"icd10_title": "Other congenital malformations of lower limb(s), including pelvic girdle"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q749",
"icd10_title": "Unspecified congenital malformation of limb(s)"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q740",
"icd10_title": "Other congenital malformations of upper limb(s), including shoulder girdle"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q741",
"icd10_title": "Congenital malformation of knee"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q875",
"icd10_title": "Other congenital malformation syndromes with other skeletal changes"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q748",
"icd10_title": "Other specified congenital malformations of limb(s)"
},
{
"from_icd11": "LB9Z",
"icd10_code": "Q89",
"icd10_title": "Other congenital malformations, not elsewhere classified"
}
] |
M228X2
|
Other disorders of patella, left knee
|
The patient is the first child of consanguineous parents. At conception, her father was 27 years old and her mother was 24 years. No family history of a similar condition was noted. Nevertheless, the mother was obese (BMI 34.6) and she mentioned that her brother, father and grandmother had the same body build . During pregnancy the ultrasounds at the first- and second-trimester were normal whereas at 30 weeks, ventriculomegaly and enlarged biparietal diameter were noted that necessitated delivery by cesarean section (CS). Her birth weight was 3.000 kg (mean) while her birth head circumference mentioned to be large. Her birth length and Apgar score were not recorded. At the age of one week, the girl displayed bulging fontanel and a sunset appearance of eyes. She underwent shunt operation at two weeks of life. There were no complications, and she was discharged home one week after surgery. At the age of 3 months, she was admitted to a local hospital because of encephalopathy. CT scan at that time showed bilateral subdural hemorrhage . Later, several shunt infections with ventriculitis led to repeated shunt revisions. Comprehensive metabolic and infection work-up of blood, urine and cerebrospinal fluid (CSF) revealed no specific findings. At the age of 6 months, she developed generalized tonic-clonic seizures that were controlled on levetiracetam and valproates. The girl did not acquire any developmental milestones and was immobile and spastic with complete lack of communications. Macrocephaly, high forehead, deep seated eyes, bulbous nasal tip, and upturned nostrils were noted. She died at the age of 14 months due to unexplained thrombocytopenia and brain hemorrhage. Fig. 1 A Pedigree of Family I. Black filled symbols refer to individuals with ESAM phenotype, gray filled symbols refer to individuals with obesity, and black and gray filled symbols refers to the co-occurrence of ESAM phenotype and obesity in Patient I.V.3. T/T, T/C are the genotypes of the MC4R variant in the family. B Portions of the sequencing electropherograms showing the segregation of the c.731-2A>G in the family. Arrow indicates the site of variant. C A schematic diagram and 1% agarose gel showing partial amplification of the cDNA of the ESAM (from exons 4 to 7) in Patient I.V.3 and a normal control subject. Note that the patient had a shorter band in comparison to normal control. D Portion of the sequencing electropherograms showing skipping of exon 6. E Pedigree of Family II. F Portions of the sequencing electropherograms showing the segregation of the c.561G>C (p.Trp187Cys) in the family. Arrow indicates the site of variant. G The conservation of the p.Trp187 across different species. H The prediced 3D structure resulting from the change of p.Trp187 (wild type) to p.Cys187 (mutant) using PremPS tool. This substitution significantly alters the bonding network and the number of interacting amino acids within the protein structure. I Schematic diagram showing the ESAM and its protein domains and the location of all reported variants to date including our new variants (in red) Fig. 2 First row is for brain CT of Patient 1 at the age of 2 weeks showing multiple porencephalic cysts and severe ventriculomegaly ( A ), at the age of 4 months showing moderate ventriculomegaly and punctuate calcification after the shunt operation ( B ), and at the age of 6 months showing subdural hemorrhage ( C ). Second row is for CT of Patient 2 done at the age of 3 months and showing mild ventriculomegaly, right porencephalic cyst, intracranial calcification, and areas of encephalomalacia ( D ), at the of 4 years showing marked obstructed hydrocephalus ( E ) and infarction in the brainstem ( F ). Frontal facial photographs of Patient 2 at the age of 4 years showing macrodoilcocephaly, bitemporal narrowing and midface hypoplasia ( G ). Third row is for brain MRI of Patient 3 at the age of 4 months showing cortical and central atrophy, ventriculomegaly, cavum septum pellucidum, porencephalic cysts, hemorrhagic ischemic lesions of white matter, hemosiderin staining along the ependymal surfaces of the ventricular system, indicating previous parenchymal and intraventricular hemorrhage and mild cerebellar atrophy. H , I , J Frontal facial photographs of Patient 3 at the age of 3 years and 6 months showing high forehead, bitemporal narrowing, arched eyebrow and bulbous nasal tip, upturned nostrils, long eyelashes, wide nasal bridge upslanted palpebral fissures, and bow shaped mouth ( K ). Fourth row is for Patient 4. CT scan at the age of 3 weeks showing multifocal intraparenchymal hemorrhages, and diffusely hypodense brain parenchyma ( L ). Brain MRI at the age of 18 months showing subdural hemorrhage, stretched and dysmorphic corpus callosum, white matter loss, dysgyria and widened 4th ventricle stretched and atrophy of vermis and brainstem ( M , N ). Follow up CT scan at the age of 4 years showing increased extraaxial CSF, atrophic brain, rippled ventricles, encephalomalacia ( O ). Frontal facial photographs of Patient 4 at the age of 4½ years showing asymmetry of the skull, deep-seated eyes, squint, low-set ears, bulbous nasal tip, and bow shaped mouth ( P )
| 4.171875
| 0.836914
|
sec[1]/sec[0]/sec[0]/sec[0]/p[0]
|
en
| 0.999996
|
39414991
|
https://doi.org/10.1038/s10038-024-01297-8
|
[
"family",
"brain",
"that",
"ventriculomegaly",
"hemorrhage",
"shunt",
"nasal",
"esam",
"birth",
"eyes"
] |
[
{
"code": "QE70.Z",
"title": "Problems related to primary support group, including family circumstances, unspecified"
},
{
"code": "8C74.1Z",
"title": "Periodic paralysis, unspecified"
},
{
"code": "2B90.Y",
"title": "Other specified malignant neoplasms of colon"
},
{
"code": "EE61",
"title": "Superficial fibromatoses"
},
{
"code": "9B70",
"title": "Inherited retinal dystrophies"
},
{
"code": "8E7Y",
"title": "Other specified diseases of the nervous system"
},
{
"code": "LA05.Z",
"title": "Cerebral structural developmental anomalies, unspecified"
},
{
"code": "1D00.Z",
"title": "Infectious encephalitis, unspecified"
},
{
"code": "LA00.0Z",
"title": "Anencephaly, unspecified"
},
{
"code": "NA07.3Y",
"title": "Other specified diffuse brain injury"
}
] |
=== ICD-11 CODES FOUND ===
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
Also known as: Problems related to primary support group, including family circumstances, unspecified | Problems related to primary support group, including family circumstances | family problem | problem related to primary support group | Problem related to gambling in the family
[8C74.1Z] Periodic paralysis, unspecified
Also known as: Periodic paralysis, unspecified | Periodic paralysis | Westphal disease | periodic myotonia | myoplegic dystrophy
[2B90.Y] Other specified malignant neoplasms of colon
Also known as: Other specified malignant neoplasms of colon | Neuroendocrine neoplasm of colon | Colon endocrine neoplasm | Neuroendocrine carcinoma of colon | NEC - [neuroendocrine carcinoma] of colon
[EE61] Superficial fibromatoses
Also known as: Superficial fibromatoses | Pachydermodactyly | Camptodactyly or streblodactyly | Familial camptodactyly | Sporadic camptodactyly
[9B70] Inherited retinal dystrophies
Also known as: Inherited retinal dystrophies | hereditary retinal dystrophies | Amaurosis - hypertrichosis | Autosomal dominant late-onset retinal degeneration | Bothnia retinal dystrophy
Includes: Leber congenital amaurosis | Stargardt disease | Vitreoretinal dystrophy
[8E7Y] Other specified diseases of the nervous system
Also known as: Other specified diseases of the nervous system | Circumscribed brain atrophy | circumscribed cerebral atrophy | atrophic lobar sclerosis | atrophic lobar brain sclerosis
[LA05.Z] Cerebral structural developmental anomalies, unspecified
Also known as: Cerebral structural developmental anomalies, unspecified | Cerebral structural developmental anomalies | Malformations of brain | brain abnormality NOS | brain deformity NOS
[1D00.Z] Infectious encephalitis, unspecified
Also known as: Infectious encephalitis, unspecified | Infectious encephalitis, not elsewhere classified | encephalitis NOS | acute encephalitis NOS | acute brain inflammation
[LA00.0Z] Anencephaly, unspecified
Also known as: Anencephaly, unspecified | Anencephaly | anencephalic monster | anencephalus | brain absence
[NA07.3Y] Other specified diffuse brain injury
Also known as: Other specified diffuse brain injury | Brain contusion | Cerebral contusion NOS | Diffuse cortex contusion | diffuse cortical contusion
=== GRAPH WALKS ===
--- Walk 1 ---
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
--PARENT--> [QE70] Problems related to primary support group, including family circumstances
--EXCLUDES--> [?] Problems associated with upbringing
--- Walk 2 ---
[QE70.Z] Problems related to primary support group, including family circumstances, unspecified
--PARENT--> [QE70] Problems related to primary support group, including family circumstances
--EXCLUDES--> [?] Problems associated with harmful or traumatic events
--- Walk 3 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--CHILD--> [8C74.1Y] Other specified periodic paralysis
--- Walk 4 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--CHILD--> [8C74.1Y] Other specified periodic paralysis
--- Walk 5 ---
[2B90.Y] Other specified malignant neoplasms of colon
--PARENT--> [2B90] Malignant neoplasms of colon
Def: Primary malignant neoplasms arising in the colon....
--CHILD--> [2B90.0] Malignant neoplasm of ascending colon and right flexure of colon
--- Walk 6 ---
[2B90.Y] Other specified malignant neoplasms of colon
--PARENT--> [2B90] Malignant neoplasms of colon
Def: Primary malignant neoplasms arising in the colon....
--CHILD--> [2B90.2] Malignant neoplasm of transverse colon
|
[
"[QE70.Z] Problems related to primary support group, including family circumstances, unspecified\n --PARENT--> [QE70] Problems related to primary support group, including family circumstances\n --EXCLUDES--> [?] Problems associated with upbringing",
"[QE70.Z] Problems related to primary support group, including family circumstances, unspecified\n --PARENT--> [QE70] Problems related to primary support group, including family circumstances\n --EXCLUDES--> [?] Problems associated with harmful or traumatic events",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --CHILD--> [8C74.1Y] Other specified periodic paralysis",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --CHILD--> [8C74.1Y] Other specified periodic paralysis",
"[2B90.Y] Other specified malignant neoplasms of colon\n --PARENT--> [2B90] Malignant neoplasms of colon\n Def: Primary malignant neoplasms arising in the colon....\n --CHILD--> [2B90.0] Malignant neoplasm of ascending colon and right flexure of colon",
"[2B90.Y] Other specified malignant neoplasms of colon\n --PARENT--> [2B90] Malignant neoplasms of colon\n Def: Primary malignant neoplasms arising in the colon....\n --CHILD--> [2B90.2] Malignant neoplasm of transverse colon"
] |
QE70.Z
|
Problems related to primary support group, including family circumstances, unspecified
|
[
{
"from_icd11": "QE70.Z",
"icd10_code": "Z6379",
"icd10_title": "Other stressful life events affecting family and household"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z6372",
"icd10_title": "Alcoholism and drug addiction in family"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z638",
"icd10_title": "Other specified problems related to primary support group"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z639",
"icd10_title": "Problem related to primary support group, unspecified"
},
{
"from_icd11": "QE70.Z",
"icd10_code": "Z637",
"icd10_title": "Other stressful life events affecting family and household"
},
{
"from_icd11": "8C74.1Z",
"icd10_code": "G723",
"icd10_title": "Periodic paralysis"
},
{
"from_icd11": "EE61",
"icd10_code": "F54",
"icd10_title": "Psychological and behavioral factors associated with disorders or diseases classified elsewhere"
},
{
"from_icd11": "9B70",
"icd10_code": "H3552",
"icd10_title": "Pigmentary retinal dystrophy"
},
{
"from_icd11": "9B70",
"icd10_code": "H3550",
"icd10_title": "Unspecified hereditary retinal dystrophy"
},
{
"from_icd11": "9B70",
"icd10_code": "H3553",
"icd10_title": "Other dystrophies primarily involving the sensory retina"
},
{
"from_icd11": "9B70",
"icd10_code": "H3554",
"icd10_title": "Dystrophies primarily involving the retinal pigment epithelium"
},
{
"from_icd11": "9B70",
"icd10_code": "H355",
"icd10_title": "Hereditary retinal dystrophy"
},
{
"from_icd11": "LA05.Z",
"icd10_code": "Q048",
"icd10_title": "Other specified congenital malformations of brain"
},
{
"from_icd11": "LA05.Z",
"icd10_code": "Q043",
"icd10_title": "Other reduction deformities of brain"
},
{
"from_icd11": "LA05.Z",
"icd10_code": "Q049",
"icd10_title": "Congenital malformation of brain, unspecified"
}
] |
Z6379
|
Other stressful life events affecting family and household
|
The patient was a 62-year-old man who underwent gastric partial resection for GIST 2 years previously. Six months after the surgery, a single tumor emerged in the hepatic left lobe. Because it was thought that tumor was metastasis of the gastric GIST, he had started on imatinib based on the pathological and genetic evidence of the original lesion. Two months after beginning imatinib, the tumor had enlarged and the imatinib regimen was changed to sunitinib. Eleven months later, the tumor had grown further and he was referred to our hospital for surgery because the tumor was considered to be tolerant to tyrosine kinase inhibitors. His blood tests showed the following: aspartate aminotransferase, 32 U/L (normal range, 5 to 30 U/L); alanine phosphatase, 37 U/L (normal range, 10 to 30 U/L); total bilirubin 1.2 mg/dL, (normal range, 0.2 to 1.2 mg/dL); carcinoembryonic antigen, 3.5 ng/ml (normal range, < 5.0 ng/ml); and carbohydrate antigen 19–9, 8.0 U/ml (normal range, < 15 U/ml). An indocyanine green retention rate of 15 min was 15.1% with Child–Pugh grade A. Abdominal ultrasonography showed a 51-mm-wide tumor in hepatic segment 4 with heterogeneous echo and it didn't present bloodstreem increase. Sonazoid-enhanced ultrasonography with hypervolemic contrasting pattern revealed that the tumor was enhanced in the early phase and washed out in the late phase . Enhanced computed tomography showed a 40-mm-diameter tumor in hepatic segments 3 and 4 (S3 + 4) with an enhanced solid nodule along the wall . On the right side of the tumor, there was an additional 50-mm tumor, which suggested a hemorrhagic cyst . Gadolinium-enhanced magnetic resonance imaging also showed an enhanced S3 + 4 tumor, a hemorrhagic cyst, and small nodules, which represented enhancement defects in the hepatocyte phase in hepatic segments 6 (S6), 7 (S7), and 8 (S8) . 18 F-Fluorodeoxyglucose positron-emission tomography showed a high FDG uptake lesion in only the S3 + 4 tumor verge. No evidence of metastasis from other organs was observed . Although the imaging findings which suggested that the tumors were possibly other hepatic malignant tumors such as hepatocellular carcinoma had been considered, we diagnosed the tumors as hepatic metastases of gastric GIST because of the existence of multiple tumors and treatment progress. We performed hepatic left lobectomy and partial resections for three lesions. Intraoperative ultrasonography showed the tumor in hepatic medial segment and hematoma between the tumor and middle hepatic vein. The tumor measuring 73 mm × 65 mm × 36 mm in the resected left lobe showed a 40-mm white solid component, an adjoining 22-mm black nodule, and a cystic lesion with bleeding close to the margin . The histopathological findings showed that the spindle-shaped cells with nuclear atypia and eosinophilic cytoplasm proliferated diffusely in the solid component . Characteristically, the tumor cells were full of pleomorphism. The partially resected specimens did not contain tumor tissues. The S6 nodule was a cyst, while the S7 and S8 specimens represented dilated ducts. Accordingly, those lesions were not considered GIST metastases. Immunohistochemical analysis showed that desmin was positive, α-smooth muscle actin (α-SMA) was slightly positive, and heavy caldesmon and muscle actin (HHF35) were positive in 30% of the tumor tissue . S-100 protein and myogenic differentiation 1 (MyoD1) did not present significant staining , and c-kit and CD34 were negative. Fig. 1 Abdominal ultrasonography findings. A 51-mm-wide tumor in hepatic segment 4 with heterogeneous echo was detected and it didn't present bloodstream increase. Sonazoid enhanced ultrasonography with hypervolemic contrasting pattern revealed that the tumor was enhanced in the early phase and washed out in the late phase Fig. 2 Enhanced computed tomography findings. A 40-mm-diameter tumor in hepatic segments 3 and 4 (S3+4) with enhanced solid nodule along the wall was detected. On the right side of the tumor, there was a 50-mm tumor, which suggested hemorrhagic cyst Fig. 3 Gadolinium-enhanced magnetic resonance imaging findings. In addition to main tumor in S3+4 ( a ), small nodules that represented enhancement defect in the hepatocyte phase were detected in S6 (2 b ), S7 (2 c ), and S8 (2 d ) Fig. 4 18F‑fluorodeoxyglucose positron-emission tomography findings. The S3+4 tumor verge represented high FDG accumulation (SUVmax=12.13) Fig. 5 Photograph of resected specimen. The tumor measuring 73 mm × 65 mm × 36 mm in the resected left lobe showed a 40-mm white solid component and a 22-mm black nodule adjoining Fig. 6 Histopathological findings. The spindle‑shaped cells with nuclear atypia and eosinophilic cytoplasm proliferated diffusely. The tumor cells were full of pleomorphism. a : Hematoxylin-Eosin staining, ×50 b : Hematoxylin-Eosin staining, ×200 Fig. 7 Immunohistochemical findings. Desmin was positive ( a , ×200), α-smooth muscle actin (α-SMA) was slightly positive ( b , ×200), and heavy-caldesmon ( c , ×200) and muscle actin (HHF35) ( d , ×200) was positive in 30% of the tumor tissue. Myogenic differentiation 1 (MyoD1) ( e , ×200) did not present significant staining
| 4.066406
| 0.975098
|
sec[1]/p[0]
|
en
| 0.999998
|
30993477
|
https://doi.org/10.1186/s40792-019-0622-9
|
[
"tumor",
"hepatic",
"enhanced",
"that",
"phase",
"range",
"ultrasonography",
"solid",
"nodule",
"gist"
] |
[
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
},
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
=== GRAPH WALKS ===
--- Walk 1 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F92] Neoplasms of unknown behaviour of skin
--- Walk 2 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F92] Neoplasms of unknown behaviour of skin
--- Walk 3 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--PARENT--> [?] General symptoms
--- Walk 4 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--CHILD--> [?] Generalised lymph node enlargement
--- Walk 5 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system
--- Walk 6 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs
|
[
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F92] Neoplasms of unknown behaviour of skin",
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F92] Neoplasms of unknown behaviour of skin",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --PARENT--> [?] General symptoms",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --CHILD--> [?] Generalised lymph node enlargement",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs"
] |
2F9Z
|
Neoplasms of unknown behaviour of unspecified site
|
[
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2242",
"icd10_title": "Localized swelling, mass and lump, left lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2231",
"icd10_title": "Localized swelling, mass and lump, right upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2241",
"icd10_title": "Localized swelling, mass and lump, right lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2233",
"icd10_title": "Localized swelling, mass and lump, upper limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2243",
"icd10_title": "Localized swelling, mass and lump, lower limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2230",
"icd10_title": "Localized swelling, mass and lump, unspecified upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R220",
"icd10_title": "Localized swelling, mass and lump, head"
}
] |
D487
|
Neoplasm of uncertain behavior of other specified sites
|
A 55-year-old middle-aged woman was admitted to the hospital on April 22, 2023, with a history of cough and expectoration for over 20 days. Approximately 20 days prior, the patient experienced an unexplained onset of cough, producing a small amount of white sputum accompanied by chest tightness and dyspnea, which were predominant with exertion. There were no complaints of chest pain or hemoptysis. Initial antibiotic treatment at a local clinic was ineffective, prompting a visit to our outpatient department. A chest computed tomography (CT) scan revealed an irregular soft tissue density shadow at the left hilar region, with narrowing of the left main bronchus and the bronchi of the upper and lower lobes of the left lung. Additionally, a segmental consolidation shadow was observed in the lingual segment of the left upper lobe . The patient had a history of partial thyroidectomy and denied any history of hypertension, coronary artery disease, diabetes, or other underlying conditions. There was no history of hepatitis B, tuberculosis, human immunodeficiency virus, or other infectious diseases. Upon admission, the patient’s vital signs were normal. The patient was alert and in good spirits. Auscultation of the lungs revealed coarse breath sounds without adventitious sounds or pleural friction rub. The heart rhythm was regular, and no pathological murmurs were heard in any of the valve areas. The abdomen was soft, without tenderness or rebound tenderness, and there was no edema in the lower extremities. Further laboratory tests showed a C-reactive protein level of 14.48 mg/L, albumin 37.5 g/L, fasting blood glucose 7.76 mmol/L, with no significant abnormalities detected in the complete blood count, liver function, renal function, electrolytes, or coagulation profile. The test for Cryptococcus neoformans capsular antigen in blood was negative, suggesting a low likelihood of cryptococcal infection. Additionally, the Mycobacterium tuberculosis -specific T-cell detection test yielded negative results, indicating the absence of M tuberculosis -specific effector T lymphocytes in the patient’s blood specimen and making pulmonary tuberculosis less probable. A comprehensive ultrasound evaluation of the cervical and supraclavicular lymph nodes demonstrated multiple hypoechoic nodules in the left cervical region and left supraclavicular fossa. These nodules exhibited well-defined margins, rounded morphology (long-axis/short-axis ratio < 2) and loss of fatty hilum. The sonographic features are indicative of lymph nodes with atypical structures, and ultrasound-guided core needle biopsy is recommended for definitive histopathological characterization. Given the patient’s poor response to anti-infective treatment, the presence of atypical structural lymph nodes, and the characteristics of hilar mass on CT imaging, the possibility of lung malignancy was considered high. On April 25th, a contrast enhanced CT scan of the chest was performed, showing no absorption changes in the lesion, with heterogeneous enhancement, and strip-like consolidative atelectasis in the lingular segment of the left upper lobe, suggesting possible lung cancer . Further bronchoscopy revealed mucosal infiltrative changes at the distal end of the left main bronchus, with the lumen almost completely narrowed, preventing the bronchoscope from entering the upper and lower lobes of the left lung . Bronchoscopy also favored a diagnosis of lung cancer. Pathological results on April 29th indicated acute and chronic bronchial inflammation with inflammatory and fibrinous exudates. The histopathological nature of the patient’s tissue was difficult to definitively characterize. Immunohistochemical studies were supplemented to assist in diagnosis, with leukocyte common antigen positivity localized to lymphocytes, low molecular weight cytokeratin and cytokeratin positivity localized to epithelial cells, favoring an inflammatory process. The final pathological diagnosis confirmed acute and chronic inflammation of the bronchial mucosa, accompanied by inflammatory infiltrates and fibrinous exudates. Pathologists at Shandong Tumor Hospital reviewed slides and described acute and chronic bronchial inflammation with squamous metaplasia and exudative tissue. Pathology suggested inflammatory disease, and the patient received azithromycin and ceftriaxone for infection during hospitalization but showed little improvement in symptoms. To clarify the nature of the pulmonary lesion, the pathological tissue wax block underwent metagenomic next-generation sequencing (NGS) and detected Nocardia farcinica (607 sequences), Supplemental Digital Content, https://links.lww.com/MD/O946 . The final diagnosis was PN ( N farcinica ). After discharge, the patient was prescribed oral trimethoprim-sulfamethoxazole (TMP-SMX) at a dose of 2 tablets (400 mg sulfamethoxazole/160 mg trimethoprim) 4 times daily for a 6-month treatment course. Follow-up outpatient chest CT scans on June 1, 2023 and November 2, 2023 showed a significant reduction in lesion extent and bronchial lumen patency has slightly improved . Another scan on April 14, 2024 showed roughly similar lesions to the previous scans.
| 4.105469
| 0.969238
|
sec[1]/p[0]
|
en
| 0.999999
|
40388761
|
https://doi.org/10.1097/MD.0000000000042524
|
[
"chest",
"lung",
"april",
"tissue",
"tuberculosis",
"pathological",
"blood",
"bronchial",
"inflammatory",
"scan"
] |
[
{
"code": "CB7Z",
"title": "Diseases of the respiratory system, unspecified"
},
{
"code": "CB27",
"title": "Pleural effusion"
},
{
"code": "CA44",
"title": "Pyothorax"
},
{
"code": "MD30.Z",
"title": "Chest pain, unspecified"
},
{
"code": "NA80.Y&XJ1C6",
"title": "Thoracic haematoma"
},
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "LA75.1",
"title": "Agenesis of lung"
},
{
"code": "CA40.Z",
"title": "Pneumonia, organism unspecified"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "NB32.3Y",
"title": "Other injury of lung"
}
] |
=== ICD-11 CODES FOUND ===
[CB7Z] Diseases of the respiratory system, unspecified
Also known as: Diseases of the respiratory system, unspecified | disorder of respiratory system | respiratory disease NOS | respiratory tract disease | respiratory disorder NOS
[CB27] Pleural effusion
Definition: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces.
Also known as: Pleural effusion | PE - [pleural effusion] | Pleurisy with effusion | pleurisy with effusion NOS | pleural effusion with transudate
Includes: Pleurisy with effusion
Excludes: Tuberculosis of the respiratory system | Chylous effusion | Pleurisy
[CA44] Pyothorax
Definition: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or penetrating trauma with a secondary infection.
Also known as: Pyothorax | empyema | pyopneumothorax | Pyothorax with fistula | empyema with fistula
Includes: empyema | pyopneumothorax
Excludes: due to tuberculosis
[MD30.Z] Chest pain, unspecified
Also known as: Chest pain, unspecified | Pain in throat or chest | chest pain NOS | pain in chest | chest pressure
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[LA75.1] Agenesis of lung
Definition: This refers to the absence or rudimentary residua of an undeveloped lung.
Also known as: Agenesis of lung | Pulmonary agenesis | absence of lung | aplasia of lung | apulmonism
[CA40.Z] Pneumonia, organism unspecified
Also known as: Pneumonia, organism unspecified | Pneumonia | infectious pneumonia | PN - [pneumonia] | lobar pneumonia NOS
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[NB32.3Y] Other injury of lung
Also known as: Other injury of lung | Haematoma of lung | Traumatic hydropneumothorax | Acute traumatic lung congestion | Rupture of lung
=== GRAPH WALKS ===
--- Walk 1 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases
Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....
--- Walk 2 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases
Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....
--- Walk 3 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Pleurisy
Def: Pleurisy or Pleuritis is the medical term for inflammation of the pleura. The most common cause of pleuritis is infection, but it can also be caused by lupus, rheumatoid arthritis, and certain medicin...
--CHILD--> [?] Chronic pleurisy
--- Walk 4 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Chylous effusion
Def: A chylothorax (chylous effusion) signifies leakage of chyle from the thoracic duct. A pleural fluid triglyceride concentration of more than 110 mg per decilitre signifies a high likelihood of chylotho...
--PARENT--> [?] Other pleural conditions
Def: Any other condition effecting the thin serous membrane enveloping the lungs and lining the thoracic cavity...
--- Walk 5 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--CHILD--> [?] Tuberculous empyema, without mention of bacteriological or histological confirmation
--- Walk 6 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...
|
[
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases\n Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....",
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --EXCLUDES--> [?] Endocrine, nutritional or metabolic diseases\n Def: This chapter includes endocrine diseases, nutritional diseases as well as metabolic diseases....",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Pleurisy\n Def: Pleurisy or Pleuritis is the medical term for inflammation of the pleura. The most common cause of pleuritis is infection, but it can also be caused by lupus, rheumatoid arthritis, and certain medicin...\n --CHILD--> [?] Chronic pleurisy",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Chylous effusion\n Def: A chylothorax (chylous effusion) signifies leakage of chyle from the thoracic duct. A pleural fluid triglyceride concentration of more than 110 mg per decilitre signifies a high likelihood of chylotho...\n --PARENT--> [?] Other pleural conditions\n Def: Any other condition effecting the thin serous membrane enveloping the lungs and lining the thoracic cavity...",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --CHILD--> [?] Tuberculous empyema, without mention of bacteriological or histological confirmation",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba..."
] |
CB7Z
|
Diseases of the respiratory system, unspecified
|
[
{
"from_icd11": "CB7Z",
"icd10_code": "J989",
"icd10_title": "Respiratory disorder, unspecified"
},
{
"from_icd11": "CB7Z",
"icd10_code": "X",
"icd10_title": ""
},
{
"from_icd11": "CB7Z",
"icd10_code": "J09-J18",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J910",
"icd10_title": "Malignant pleural effusion"
},
{
"from_icd11": "CB27",
"icd10_code": "J918",
"icd10_title": "Pleural effusion in other conditions classified elsewhere"
},
{
"from_icd11": "CB27",
"icd10_code": "J90",
"icd10_title": "Pleural effusion, not elsewhere classified"
},
{
"from_icd11": "CB27",
"icd10_code": "J90-J94",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J91",
"icd10_title": "Pleural effusion in conditions classified elsewhere"
},
{
"from_icd11": "CA44",
"icd10_code": "J869",
"icd10_title": "Pyothorax without fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J860",
"icd10_title": "Pyothorax with fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J85-J86",
"icd10_title": ""
},
{
"from_icd11": "CA44",
"icd10_code": "J86",
"icd10_title": "Pyothorax"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0781",
"icd10_title": "Pleurodynia"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0782",
"icd10_title": "Intercostal pain"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R079",
"icd10_title": "Chest pain, unspecified"
}
] |
J989
|
Respiratory disorder, unspecified
|
A 62-year-old female patient had an unremarkable clinical history until the age of 41, when a diagnosis of autoimmune thyroiditis with euthyroidism was established. At age of 47, she experienced bilateral ptosis, diplopia, weakness of masticatory muscles and generalized fatigability involving four limbs. Diagnosis of myasthenia gravis (MG) was posed on the basis of a positive repetitive nerve stimulation test and circulating anti acetylcholine-receptor antibodies. MG was found to be associated with a thymoma treated with thymectomy. At age of 59, due to onset of acute diarrhea (up to 10 bowel movements / day) with fecal incontinence, the colon-ileoscopy of the patient showed a normal large bowel and terminal ileum mucosa. A summary of the most relevant clinical, laboratory and histopathological findings has been reported in Table 1 . A few months later, the patient experienced worsening of the diarrhea (up to 15 bowel movements / day) with abdominal pain, weight loss (about 8 kg in the last 6 months), muscle cramps and numbness. Blood tests revealed low levels of Vitamin D3, serum albumin, and electrolytes (i.e., Ca++, Mg++, K+). Serological tests for celiac disease (i.e., IgA tissue transglutaminase – tTGA; IgA endomysial – EmA; and IgG deamidated gliadin antibodies - DGP) were negative. Total serum IgA levels resulted in the normal range. Screening for immune markers showed a positive result for antinuclear antibodies on HEp2-cells (ANA 1:80 with a nucleolar pattern). Due to the persistence of severe malabsorption syndrome, the patient underwent an upper gastrointestinal endoscopy with duodenal biopsy, which revealed subtotal villous atrophy (grade III according to Marsh classification) ( 6 ). Genetic testing was consistent with CD diagnosis and showed positive HLA-DQ2 in heterozygosis. Based on the histopathological and genetic findings, the patient was diagnosed as seronegative CD and started GFD. Despite adherence to gluten withdrawal, her condition continued to worsen due to persistent diarrhea and significant laboratory abnormalities, i.e. low levels of albumin, folic acid, Mg++ and K+. The lack of response to GFD was attributed to an inadvertent gluten contamination since the patient was a baker. The patient was hospitalized in the Department of Gastroenterology of the University of Pisa, because symptoms (diarrhea, nausea and anorexia) did not resolve. On admission, physical examination revealed a malnourished patient (BMI = 19) and laboratory tests showed a macrocytic anemia (Hb 11.5 g / dL), low levels of folic acid, vitamin D3, albumin and Mg++. Due to lack of clinical and laboratory responses to GFD, an upper gastrointestinal endoscopy was performed to check the status of small intestinal mucosa. The duodenal biopsy documented a persistent subtotal villous atrophy with crypt hyperplasia and increased number of IELs (40%-60%), thus challenging the diagnosis of CD. Other causes of villous atrophy, including: parasitic infection ( Giardia lamblia ), small intestine bacterial overgrowth, immunodeficiencies, eosinophilc gastroenteritis, drug-induced enteropathy (related to non-steroidal anti-inflammatory drugs and angiotensin II inhibitors) and Whipple disease were excluded by appropriate investigations. The patient was re-hydrated and treated with parenteral nutrition, electrolyte supplementation and albumin; gluten was reintroduced in the diet. Following a partial improvement (mild weight increase), the patient was discharged. However, she was re-admitted in the same Gastroenterology unit few months later due to sudden deterioration characterized by hypocalcaemia-related tetany, mild macrocytic anemia, low serum levels of Mg++ and severe hypoalbuminemia with mild ascites confirmed by CT scan. Serology for CD (EmA, tTGA, DGP) was confirmed to be negative. Apart from ANA and anti-acetylcholine-receptor antibodies, a thorough autoimmune profile, including: non-organ specific (smooth muscle, mitochondrial and liver-kidney microsomal) and organ specific (gastric parietal cells, glutamate decarboxylase, neurohypophysis) antibodies were negative. EAA, performed in the Immunology Laboratory of the Bologna University, disclosed positivity for IgG and IgA antibodies at the titer of 1:400 and 1:100, respectively . Due to this finding, supporting the diagnosis of autoimmune enteropathy, the patient started methylprednisolone (0.5 mg/kg/day) and azathioprine (50 mg/day for 7 days and then increased up to 100 mg/day) and showed a rapid significant clinical improvement. Diarrhea resolved in 15 days and the patient gained weight progressively until reaching a normal BMI in a few months. Laboratory findings progressively normalized due to the improved mineral and vitamin absorption. After 6 months of immunosuppressive treatment, EAA IgA antibodies were negative, whereas EAA IgG antibodies persisted positive at a reduced titer (1:100). Methylprednisolone was progressively tapered down to 4 mg/day, whereas azathioprine was replaced by 6-mercaptopurine due to vomiting. The patient’s clinical conditions are steadily improving with a complete remission of symptoms and weight gain after six months of follow-up.
| 4.136719
| 0.97168
|
sec[1]/p[0]
|
en
| 0.999998
|
27099674
|
N/A
|
[
"antibodies",
"laboratory",
"diarrhea",
"weight",
"albumin",
"autoimmune",
"anti",
"bowel",
"vitamin",
"serum"
] |
[
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MA14.14",
"title": "Anti-nuclear antibody positive"
},
{
"code": "MA14.13",
"title": "Anti-nuclear antibody negative"
},
{
"code": "JA86.0",
"title": "Maternal care for red cell antibodies"
},
{
"code": "MA14.1C",
"title": "Raised antibody titre"
},
{
"code": "QA00.C",
"title": "Laboratory examination"
},
{
"code": "MG71.Z",
"title": "Abnormal laboratory results, not elsewhere classified, unspecified"
},
{
"code": "MG71.Y",
"title": "Other specified abnormal laboratory results, not elsewhere classified"
},
{
"code": "QA0B",
"title": "Preprocedural examination"
},
{
"code": "MA14.0",
"title": "Laboratory evidence of human immunodeficiency virus"
}
] |
=== ICD-11 CODES FOUND ===
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MA14.14] Anti-nuclear antibody positive
Also known as: Anti-nuclear antibody positive | ANA - [anti-nuclear antibody] positive
[MA14.13] Anti-nuclear antibody negative
Also known as: Anti-nuclear antibody negative | ANA - [anti-nuclear antibody] negative
[JA86.0] Maternal care for red cell antibodies
Definition: Maternal care for rhesus or other isoimmunization
Also known as: Maternal care for red cell antibodies | Maternal care for rhesus isoimmunization | Rh factor immunization affecting management of pregnancy | Rh incompatibility | Rh incompatibility with hydrops fetalis
[MA14.1C] Raised antibody titre
Also known as: Raised antibody titre | antibody titre above reference range | high antibody titre | increased antibody titre
Excludes: isoimmunization, in pregnancy affecting fetus or newborn
[QA00.C] Laboratory examination
Also known as: Laboratory examination | laboratory test
[MG71.Z] Abnormal laboratory results, not elsewhere classified, unspecified
Also known as: Abnormal laboratory results, not elsewhere classified, unspecified | Abnormal laboratory results, not elsewhere classified
[MG71.Y] Other specified abnormal laboratory results, not elsewhere classified
Also known as: Other specified abnormal laboratory results, not elsewhere classified
[QA0B] Preprocedural examination
Definition: Evaluation and testing for assessment and proactive management of risks of perioperative morbidity and mortality and implements measurements to minimize risks.
Also known as: Preprocedural examination | Encounter for preoperative examinations | Preprocedural general examination | Encounter for preprocedural examination NOS | preoperative assessment
[MA14.0] Laboratory evidence of human immunodeficiency virus
Also known as: Laboratory evidence of human immunodeficiency virus | human immunodeficiency virus test positive | positive test for HIV | laboratory evidence of HIV | Nonconclusive HIV-test finding in infants
Excludes: Human immunodeficiency disease complicating pregnancy, childbirth or the puerperium | Human immunodeficiency virus disease | Asymptomatic human immunodeficiency virus infection
=== GRAPH WALKS ===
--- Walk 1 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--CHILD--> [JA86.0] Maternal care for red cell antibodies
Def: Maternal care for rhesus or other isoimmunization...
--- Walk 2 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia
--- Walk 3 ---
[MA14.14] Anti-nuclear antibody positive
--PARENT--> [MA14.1] Certain specified immunological findings
--PARENT--> [MA14] Immunological findings in blood, blood-forming organs, or the immune system
--- Walk 4 ---
[MA14.14] Anti-nuclear antibody positive
--PARENT--> [MA14.1] Certain specified immunological findings
--CHILD--> [MA14.12] Anticitrullinated protein antibody positive
--- Walk 5 ---
[MA14.13] Anti-nuclear antibody negative
--PARENT--> [MA14.1] Certain specified immunological findings
--CHILD--> [MA14.10] Abnormal reaction to tuberculin test
--- Walk 6 ---
[MA14.13] Anti-nuclear antibody negative
--PARENT--> [MA14.1] Certain specified immunological findings
--CHILD--> [MA14.11] Anticitrullinated protein antibody negative
|
[
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --CHILD--> [JA86.0] Maternal care for red cell antibodies\n Def: Maternal care for rhesus or other isoimmunization...",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia",
"[MA14.14] Anti-nuclear antibody positive\n --PARENT--> [MA14.1] Certain specified immunological findings\n --PARENT--> [MA14] Immunological findings in blood, blood-forming organs, or the immune system",
"[MA14.14] Anti-nuclear antibody positive\n --PARENT--> [MA14.1] Certain specified immunological findings\n --CHILD--> [MA14.12] Anticitrullinated protein antibody positive",
"[MA14.13] Anti-nuclear antibody negative\n --PARENT--> [MA14.1] Certain specified immunological findings\n --CHILD--> [MA14.10] Abnormal reaction to tuberculin test",
"[MA14.13] Anti-nuclear antibody negative\n --PARENT--> [MA14.1] Certain specified immunological findings\n --CHILD--> [MA14.11] Anticitrullinated protein antibody negative"
] |
JA86.Y
|
Maternal care for other specified fetal problems
|
[
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360930",
"icd10_title": "Maternal care for other rhesus isoimmunization, third trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360920",
"icd10_title": "Maternal care for other rhesus isoimmunization, second trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360130",
"icd10_title": "Maternal care for anti-D [Rh] antibodies, third trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360932",
"icd10_title": "Maternal care for other rhesus isoimmunization, third trimester, fetus 2"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360922",
"icd10_title": "Maternal care for other rhesus isoimmunization, second trimester, fetus 2"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360990",
"icd10_title": "Maternal care for other rhesus isoimmunization, unspecified trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360110",
"icd10_title": "Maternal care for anti-D [Rh] antibodies, first trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360120",
"icd10_title": "Maternal care for anti-D [Rh] antibodies, second trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360910",
"icd10_title": "Maternal care for other rhesus isoimmunization, first trimester, not applicable or unspecified"
},
{
"from_icd11": "JA86.0",
"icd10_code": "O360",
"icd10_title": "Maternal care for rhesus isoimmunization"
},
{
"from_icd11": "MA14.1C",
"icd10_code": "R760",
"icd10_title": "Raised antibody titer"
}
] |
O26841
| |
A 59-year-old man (170 cm, 78 kg) had cerebral infarction of the right precentral gyrus 2 years prior presentation and was diagnosed with bilateral ICA stenosis. He was treated conservatively (oral cilostazol and clopidogrel) and followed up; however, the stenosis of the left ICA progressed. Therefore, he was scheduled for CEA. There were no apparent complications related to his previous cerebral infarction. He was receiving an oral treatment for hypertension and dyslipidemia and had a long history of smoking (40 cigarettes per day for 40 years). There were no other notable findings in preoperative examinations. On the day of surgery, he was admitted to the operating room without premedication. Pre-oxygenation was performed using a mask without headband. Anesthesia was induced using 200 μg fentanyl and 5 mg midazolam, and 60 mg rocuronium was given to facilitate tracheal intubation. A Macintosh laryngoscope was used to expose the larynx. The view was classified as Cormack III. We attempted a tracheal intubation with a endotracheal tube (Shiley™ Endotracheal Tube with TaperGuard™ Cuff 7.5 mm), but the esophagus was inadvertently intubated, so it was removed. The second tracheal intubation by using a Macintosh laryngoscope was successful. Wheals appeared on the upper limbs, neck, and precordium without any vital sign changes after infusion of cefazolin sodium as a preoperative antibiotic, so administration was discontinued. The skin signs were believed to be an allergic reaction to cefazolin, which was changed to fosfomycin, and the patient also received an intravenous infusion containing 200 mg of hydrocortisone sodium phosphate. During surgery, he was placed in the supine position, but the neck was slightly rotated and lateroflexed to the right to secure the surgical field. Anesthesia was maintained with 1.4% sevoflurane and remifentanil at a dose of 0.2 μg/kg/min. Mild hypotension was observed intraoperatively. This was managed with fluid infusions and continuous administration of an appropriate dose of noradrenaline. Surgery was concluded without problems, and the preoperatively observed wheals resolved. Endotracheal aspiration was performed after waking up the patient, but it triggered a strong cough reflex. The patient was then extubated. The duration of surgery was 4 h and 57 min, the duration of anesthesia was 6 h and 29 min, the volume of blood loss was negligible, the in-out balance was + 3210 mL , and mild swelling of the face and both upper limbs was noted. The patient was admitted to the intensive care unit (ICU) in a lucid state with a blood pressure of 120/70 mmHg, a heart rate of 110 beats/min, oxygen saturation of 100% on 3 L of nasal oxygen and respiratory rate of 12 breaths/min. His arterial blood gas analysis was normal, and mild hoarseness was noted without swelling of the neck or stridor. Six hours after admission to the ICU mild bilateral neck swelling appeared. The hoarseness rapidly worsened, and tachypnea and stridor appeared 1 h later without oxygen desaturation. Emergency intubation with a tube (Shiley™ Evac Endotracheal Tube with TaperGuard™ Cuff 7.5 mm) was immediately performed with mild sedation with propofol under spontaneous breathing on suspicion of upper airway obstruction. We used a video laryngoscope (HOYA Co. Ltd., airway scope) with a gum elastic bougie tube introducer. Laryngopharyngeal findings at this time included no epiglottic edema. However, the edema of the lateral and posterior pharyngeal walls was present, and it narrowed the oral and pharyngeal cavities. The neck swelling was pronounced, and the neck circumference was 63 cm . A CT scan was performed to investigate the cause and to facilitate differential diagnosis of possible postoperative hemorrhage, but no bleeding was observed. The bilateral parotid and salivary glands were markedly swollen , and the edema of the posterior pharyngeal wall was developed when compared to the preoperative state. Blood test results revealed a leukocyte count of 8000/μL (eosinophils 0%), amylase at 1790 U/L, mumps immunoglobulin G (IgG) at 16.6 (+), mumps IgM at 0.27 (−), and C-reactive protein at 0.18. Based on these findings, we concluded that the patient had previously suffered from a mumps infection, but had no active disease. Moreover, he only presented with the clinical features of sialadenitis. We commenced administration of steroids to reduce the edema. On postoperative day (POD) 2, the serum amylase decreased to 457 U/L, gradual improvement of the bilateral parotid gland swelling was observed, and the patient was extubated. The subsequent clinical course was favorable, and the neck swelling disappeared. The general condition, airways, and ability to swallow were all normal when the patient was discharged on POD 11. Fig. 1 Photograph showing the swelling of his neck 7 h after the operation Fig. 2 Post-operative image of computed tomography scans at the parotid glands level shows the bilateral parotid glands were swollen compared to the pre-operative state Fig. 3 Post-operative image of computed tomography scans shows the edema of the posterior pharyngeal wall was developed compared to the pre-operative state
| 3.828125
| 0.977051
|
sec[1]/p[0]
|
en
| 0.999997
|
32025931
|
https://doi.org/10.1186/s40981-018-0159-0
|
[
"neck",
"swelling",
"without",
"tube",
"edema",
"intubation",
"endotracheal",
"blood",
"state",
"pharyngeal"
] |
[
{
"code": "ME86.C",
"title": "Symptom or complaint of the neck"
},
{
"code": "LA6Z",
"title": "Structural developmental anomalies of the neck, unspecified"
},
{
"code": "ME84.0",
"title": "Cervical spine pain"
},
{
"code": "FA71",
"title": "Torticollis"
},
{
"code": "NA23.4Y",
"title": "Other specified strain or sprain of cervical spine"
},
{
"code": "FA36.Z",
"title": "Effusion of joint, unspecified"
},
{
"code": "MA01.Z",
"title": "Enlarged lymph nodes, unspecified"
},
{
"code": "MD82",
"title": "Intra-abdominal or pelvic swelling, mass or lump"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "GB90.Y",
"title": "Other specified disorders of kidney or ureter"
}
] |
=== ICD-11 CODES FOUND ===
[ME86.C] Symptom or complaint of the neck
Also known as: Symptom or complaint of the neck | Neck syndrome
Excludes: Chronic primary musculoskeletal pain | Chronic secondary musculoskeletal pain
[LA6Z] Structural developmental anomalies of the neck, unspecified
Also known as: Structural developmental anomalies of the neck, unspecified | Malformations of the neck
[ME84.0] Cervical spine pain
Definition: This is a condition which is usually characterised by pain or discomfort in the neck region and can be caused by numerous spinal problems. It may be a feature of virtually every disorder and disease that occurs above the shoulder blades.
Also known as: Cervical spine pain | cervical pain | neck ache | nonspecific pain in the neck region | cervicalgia
Includes: cervicalgia
Excludes: cervical disc degeneration | Chronic primary cervical pain | Chronic secondary musculoskeletal pain
[FA71] Torticollis
Also known as: Torticollis | contracture of neck | wry neck | wry neck/torticollis | Intermittent torticollis
Excludes: Cervical dystonia | Congenital torticollis | current injury - see injury of spine by body region
[NA23.4Y] Other specified strain or sprain of cervical spine
Also known as: Other specified strain or sprain of cervical spine | Strain of cervical spine | cervical strain | Strain of cervical anterior longitudinal ligament | Sprain of cervical spine
[FA36.Z] Effusion of joint, unspecified
Also known as: Effusion of joint, unspecified | Effusion of joint | effusion into joint | effusion of joint, site unspecified | hydrarthrosis
[MA01.Z] Enlarged lymph nodes, unspecified
Also known as: Enlarged lymph nodes, unspecified | Enlarged lymph nodes | swollen glands | Lymphadenopathy | adenopathy
[MD82] Intra-abdominal or pelvic swelling, mass or lump
Definition: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation.
Also known as: Intra-abdominal or pelvic swelling, mass or lump | Abdominal mass without further specification | mass in abdomen | intra-abdominal lump | intra-abdominal mass
Excludes: Abdominal distension | Ascites
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[GB90.Y] Other specified disorders of kidney or ureter
Also known as: Other specified disorders of kidney or ureter | Other secondary disorders of kidney or ureter | Other disorders of kidney and ureter NEC | Inflammatory diseases of the renal pelvis or the ureter without tubulo-interstitial nephritis | Infectious diseases of the renal pelvis or the ureter without tubulo-interstitial nephritis
=== GRAPH WALKS ===
--- Walk 1 ---
[ME86.C] Symptom or complaint of the neck
--PARENT--> [ME86] Symptom or complaint of a body part
--CHILD--> [ME86.0] Symptom or complaint of the ankle
--- Walk 2 ---
[ME86.C] Symptom or complaint of the neck
--EXCLUDES--> [?] Chronic secondary musculoskeletal pain
Def: Chronic secondary musculoskeletal pain is chronic pain arising from bone(s), joint(s), muscle(s), vertebral column, tendon(s) or related soft tissue(s). It is a heterogeneous group of chronic pain con...
--EXCLUDES--> [?] Chronic neuropathic pain
Def: Chronic neuropathic pain is chronic pain caused by a lesion or disease of the somatosensory nervous system. The pain may be spontaneous or evoked, as an increased response to a painful stimulus (hyper...
--- Walk 3 ---
[LA6Z] Structural developmental anomalies of the neck, unspecified
--PARENT--> [?] Structural developmental anomalies of the neck
Def: Any condition caused by failure of the neck to correctly develop during the antenatal period....
--CHILD--> [LA61] Congenital sternomastoid tumour
--- Walk 4 ---
[LA6Z] Structural developmental anomalies of the neck, unspecified
--PARENT--> [?] Structural developmental anomalies of the neck
Def: Any condition caused by failure of the neck to correctly develop during the antenatal period....
--CHILD--> [LA61] Congenital sternomastoid tumour
--- Walk 5 ---
[ME84.0] Cervical spine pain
Def: This is a condition which is usually characterised by pain or discomfort in the neck region and can be caused by numerous spinal problems. It may be a feature of virtually every disorder and disease t...
--EXCLUDES--> [?] Chronic secondary musculoskeletal pain
Def: Chronic secondary musculoskeletal pain is chronic pain arising from bone(s), joint(s), muscle(s), vertebral column, tendon(s) or related soft tissue(s). It is a heterogeneous group of chronic pain con...
--EXCLUDES--> [?] Chronic primary pain
Def: Chronic primary pain is chronic pain in one or more anatomical regions that is characterised by significant emotional distress (anxiety, anger/frustration or depressed mood) or functional disability (...
--- Walk 6 ---
[ME84.0] Cervical spine pain
Def: This is a condition which is usually characterised by pain or discomfort in the neck region and can be caused by numerous spinal problems. It may be a feature of virtually every disorder and disease t...
--EXCLUDES--> [?] Intervertebral disc degeneration
--CHILD--> [?] Intervertebral disc degeneration of cervical spine with bony spur at the vertebra
|
[
"[ME86.C] Symptom or complaint of the neck\n --PARENT--> [ME86] Symptom or complaint of a body part\n --CHILD--> [ME86.0] Symptom or complaint of the ankle",
"[ME86.C] Symptom or complaint of the neck\n --EXCLUDES--> [?] Chronic secondary musculoskeletal pain\n Def: Chronic secondary musculoskeletal pain is chronic pain arising from bone(s), joint(s), muscle(s), vertebral column, tendon(s) or related soft tissue(s). It is a heterogeneous group of chronic pain con...\n --EXCLUDES--> [?] Chronic neuropathic pain\n Def: Chronic neuropathic pain is chronic pain caused by a lesion or disease of the somatosensory nervous system. The pain may be spontaneous or evoked, as an increased response to a painful stimulus (hyper...",
"[LA6Z] Structural developmental anomalies of the neck, unspecified\n --PARENT--> [?] Structural developmental anomalies of the neck\n Def: Any condition caused by failure of the neck to correctly develop during the antenatal period....\n --CHILD--> [LA61] Congenital sternomastoid tumour",
"[LA6Z] Structural developmental anomalies of the neck, unspecified\n --PARENT--> [?] Structural developmental anomalies of the neck\n Def: Any condition caused by failure of the neck to correctly develop during the antenatal period....\n --CHILD--> [LA61] Congenital sternomastoid tumour",
"[ME84.0] Cervical spine pain\n Def: This is a condition which is usually characterised by pain or discomfort in the neck region and can be caused by numerous spinal problems. It may be a feature of virtually every disorder and disease t...\n --EXCLUDES--> [?] Chronic secondary musculoskeletal pain\n Def: Chronic secondary musculoskeletal pain is chronic pain arising from bone(s), joint(s), muscle(s), vertebral column, tendon(s) or related soft tissue(s). It is a heterogeneous group of chronic pain con...\n --EXCLUDES--> [?] Chronic primary pain\n Def: Chronic primary pain is chronic pain in one or more anatomical regions that is characterised by significant emotional distress (anxiety, anger/frustration or depressed mood) or functional disability (...",
"[ME84.0] Cervical spine pain\n Def: This is a condition which is usually characterised by pain or discomfort in the neck region and can be caused by numerous spinal problems. It may be a feature of virtually every disorder and disease t...\n --EXCLUDES--> [?] Intervertebral disc degeneration\n --CHILD--> [?] Intervertebral disc degeneration of cervical spine with bony spur at the vertebra"
] |
ME86.C
|
Symptom or complaint of the neck
|
[
{
"from_icd11": "LA6Z",
"icd10_code": "Q680",
"icd10_title": "Congenital deformity of sternocleidomastoid muscle"
},
{
"from_icd11": "LA6Z",
"icd10_code": "Q180",
"icd10_title": "Sinus, fistula and cyst of branchial cleft"
},
{
"from_icd11": "LA6Z",
"icd10_code": "Q188",
"icd10_title": "Other specified congenital malformations of face and neck"
},
{
"from_icd11": "LA6Z",
"icd10_code": "Q10-Q18",
"icd10_title": ""
},
{
"from_icd11": "LA6Z",
"icd10_code": "Q182",
"icd10_title": "Other branchial cleft malformations"
},
{
"from_icd11": "ME84.0",
"icd10_code": "M542",
"icd10_title": "Cervicalgia"
},
{
"from_icd11": "ME84.0",
"icd10_code": "M530",
"icd10_title": "Cervicocranial syndrome"
},
{
"from_icd11": "ME84.0",
"icd10_code": "M531",
"icd10_title": "Cervicobrachial syndrome"
},
{
"from_icd11": "FA71",
"icd10_code": "M436",
"icd10_title": "Torticollis"
},
{
"from_icd11": "FA71",
"icd10_code": "M43",
"icd10_title": "Other deforming dorsopathies"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25471",
"icd10_title": "Effusion, right ankle"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25461",
"icd10_title": "Effusion, right knee"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25462",
"icd10_title": "Effusion, left knee"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25431",
"icd10_title": "Effusion, right wrist"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25472",
"icd10_title": "Effusion, left ankle"
}
] |
Q680
|
Congenital deformity of sternocleidomastoid muscle
|
A 38-year-old woman with a never smoking history, was found to have multiple head subcutaneous nodules in June 2021. The diameter of the most noticeable nodule was 0.5 cm, and the nodule was hard with an unclear boundary. In July, the nodules were found to be enlarged, and the most noticeable one had a diameter of 1 cm. Then the patient went to Zhuhai Third People’s Hospital, and she underwent a fine needle aspiration biopsy of the nodules. The pathological report revealed the nodules were adenocarcinoma (ADC). The patient felt weak and dizzy, occasionally coughed with little white sputum, and the multiple subcutaneous nodules were continually growing up. On August 10th, she got a recurrent fever for several days, and her temperature fluctuated within the range of 37.2-39°C. On September 10th, positron emission tomography/computed tomography (PET/CT) at the Fifth Affiliated Hospital of Sun Yat-sen University showed positive lesions in the left hilar central lung cancer, and multicenter peripheral lung cancer at the apical posterior end of the upper lobe of the left lung. Multiple metastases were observed in both lungs, multiple lymph nodes, bilateral pleural, the left parotid gland, bilateral mammary gland, pancreatic head, bilateral adrenal gland, bilateral kidney, bones, muscles, and subcutaneous throughout the body. On September 18 th , the patient came to our hospital for treatment. A contrast-enhanced computed tomography (CT) scan of the chest confirmed the mass in the upper lobe of the left lung . A fibrobronchoscope brush biopsy was performed on the left main bronchus tumor, and the primary provided an unexpected diagnosis of squamous cell carcinoma (SQCC) with negative results for TTF-1 and positive results for CK7 and P40 . The pathological slices of the subcutaneous nodules of the scalp were borrowed from Zhuhai Third People’s Hospital. Pathological diagnosis in our hospital confirmed they were medium-differentiated ADC with a conspicuous acinar growth pattern and extracelluar mucus production . Immunohistochemically, the nodules were negative for TTF-1, Napsin A, but showed positive expression of CK7 . Given her rapidly deteriorated condition, before the NGS test report came out the patient received one cycle of chemotherapy with albumin-paclitaxel 300 mg combined with nedaplatin 80 mg injection on September 28, 2021. A panel-based next-generation sequencing (NGS) consisting of 689 cancer-associated genes ( Supplementary Table 1 ) was performed individually in the primary and subcutaneous nodules. NGS indicated ALK-EML4 (E13; A20) fusion and other mutations were shared in the two different histologic tumors with the exception of a mutation in the FARS1 gene, which was exclusively present in subcutaneous nodules, indicating they originated from the same clone ( Supplementary Tables 2 , 3 ). In the ADC of metastatic nodules, the variant allele frequency (VAF)s of EML4-ALK , STK11 , FOXP1 , CIC , and FARS1 gene were 45.21%, 35.20%, 38.82%, 40.16%, and 24.35%, respectively, while in the SQCC of main lung tumor, they were 76.33%, 56.55%, 54.47%, 49.98%, and 0 correspondingly . Finally, the patient was diagnosed with clinical stage IVB, T4N3M1c of the lung cancer possessing an ALK gene rearrangement and multiple distant metastases with an Eastern Cooperative Oncology Group performance status (ECOG PS) of 2-3. According to the 2021 National Comprehensive Cancer Network (NCCN) guidelines, and taking into account the patient’s ECOG PS, we interrupted the patient’s current chemotherapy regimen and started on alectinib 600 mg orally twice a day from September 30 th . Radiotherapy was not an option due to the extensive metastasis of the tumors. Eight weeks after this administration, the efficacy was evaluated as a partial response (PR) as CT imaging showed the shrinkage of the lung . Her ECOG PS decreased from 2-3 to 1, with improvement of hypoxia, cancer pain, and cachexia. Interestingly, subcutaneous nodules with ADC in morphology shrank more than the lung lesions (ADC). The efficacy of alectinib was evaluated as stable disease in May 2022. However, enlargement of subcutaneous nodules was noted in August 2022. In addition, the chest/abdomen/pelvic CT scans indicated the enlargement of the primary lesions and metastatic lesions . The treatment efficacy was progressive disease (PD). Therefore, we replaced with the third-generation ALK -TKI lorlatinib targeted therapy on August 25 th , 2022 for two months. The subcutaneous nodules significantly shrank and even disappeared, but the shortness of breath was aggravated after the administration of lorlatinib. She had her external plasma examined for ctDNA and found persistence of an EML4 - ALK rearrangement and an extra p.E542 mutation in PIK3CA gene ( Supplementary Table 4 ). Then the patient accepted one cycle of chemotherapy with albumin paclitaxel 350 mg and carbopoltin 400 mg combined with camrelizumab immunotherapy and recombinant human endostatinln 210 mg by injection on November 5, 2022. However, her respiratory condition deteriorated, and she died within a few days. A flowchart of the patient’s treatment timeline is provided in Figure 2J .
| 4.148438
| 0.953125
|
sec[1]/p[0]
|
en
| 0.999996
|
PMC10450948
|
https://doi.org/10.3389/fonc.2023.1209799
|
[
"nodules",
"subcutaneous",
"lung",
"cancer",
"multiple",
"september",
"lesions",
"gene",
"pathological",
"august"
] |
[
{
"code": "2E88",
"title": "Benign endometrial stromal nodule"
},
{
"code": "FA20.0",
"title": "Seropositive rheumatoid arthritis"
},
{
"code": "1F20.Z",
"title": "Aspergillosis, unspecified"
},
{
"code": "MF30",
"title": "Breast lump or mass female"
},
{
"code": "5A01.1",
"title": "Nontoxic single thyroid nodule"
},
{
"code": "EB90.40",
"title": "Dystrophic calcification of the skin of uncertain or unspecified aetiology"
},
{
"code": "ND56.0",
"title": "Superficial injury of unspecified body region"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "EM0Z",
"title": "Skin disease of unspecified nature"
},
{
"code": "EB90.2Z",
"title": "Cutaneous or subcutaneous xanthomata of unspecified type"
}
] |
=== ICD-11 CODES FOUND ===
[2E88] Benign endometrial stromal nodule
Also known as: Benign endometrial stromal nodule | benign endometrial stromal tumour | Endometrial node | Stromal nodule
[FA20.0] Seropositive rheumatoid arthritis
Also known as: Seropositive rheumatoid arthritis | high positive rheumatoid factor | low positive rheumatoid factor | high positive anticitrullinated protein antibody | low positive anticitrullinated protein antibody
[1F20.Z] Aspergillosis, unspecified
Also known as: Aspergillosis, unspecified | Aspergillosis | aspergilloma | aspergillus nodule | simple aspergilloma
[MF30] Breast lump or mass female
Also known as: Breast lump or mass female | breast irregular nodularity | breast node | lump in breast | lump or mass in breast NOS
[5A01.1] Nontoxic single thyroid nodule
Definition: Single tumour of the thyroid gland due to follicular multiplication, unaccompanied by hyperthyroidism or thyrotoxicosis
Also known as: Nontoxic single thyroid nodule | colloid goitre (in part) | follicular goitre | struma follicularis | parenchymatous goitre
[EB90.40] Dystrophic calcification of the skin of uncertain or unspecified aetiology
Definition: Abnormal deposition of calcium in the skin and subcutaneous tissues of unknown (idiopathic) or unspecified cause.
Also known as: Dystrophic calcification of the skin of uncertain or unspecified aetiology | Calcinosis cutis of uncertain or unspecified aetiology | Osteoma cutis | Cutaneous ossification | Subepidermal calcified nodule
Includes: Calcinosis cutis
[ND56.0] Superficial injury of unspecified body region
Also known as: Superficial injury of unspecified body region | superficial injury of limb NOS | Superficial injury NOS | scratch NOS | Cutaneous wounds, injuries or scars
Excludes: multiple superficial injuries NOS
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[EM0Z] Skin disease of unspecified nature
Also known as: Skin disease of unspecified nature | Diseases of cutaneous vasculature | Diseases of subcutaneous tissue | Diseases of the dermis | Diseases of the epidermis
[EB90.2Z] Cutaneous or subcutaneous xanthomata of unspecified type
Also known as: Cutaneous or subcutaneous xanthomata of unspecified type | Cutaneous or subcutaneous xanthomata | Xanthoma due to specified disorder of lipid metabolism
=== GRAPH WALKS ===
--- Walk 1 ---
[2E88] Benign endometrial stromal nodule
--PARENT--> [?] Benign mesenchymal neoplasms
Def: Bening neoplasms of muscle, fat, fibrous tissue, bone, cartilage, and blood vessels....
--CHILD--> [2E81] Benign vascular neoplasms
--- Walk 2 ---
[2E88] Benign endometrial stromal nodule
--PARENT--> [?] Benign mesenchymal neoplasms
Def: Bening neoplasms of muscle, fat, fibrous tissue, bone, cartilage, and blood vessels....
--CHILD--> [2E82] Benign chondrogenic tumours
--- Walk 3 ---
[FA20.0] Seropositive rheumatoid arthritis
--PARENT--> [FA20] Rheumatoid arthritis
Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...
--CHILD--> [FA20.1] Seronegative rheumatoid arthritis
--- Walk 4 ---
[FA20.0] Seropositive rheumatoid arthritis
--PARENT--> [FA20] Rheumatoid arthritis
Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...
--EXCLUDES--> [?] Acute rheumatic fever
Def: A disease of the connective tissue, caused by an infection with the gram-positive bacteria Streptococcus pyogenes (the disease may also affect the heart, joints, central nervous system, subcutaneous t...
--- Walk 5 ---
[1F20.Z] Aspergillosis, unspecified
--PARENT--> [1F20] Aspergillosis
Def: Aspergillosis is a disease caused by fungi of the genus Aspergillus. The organism is ubiquitous, being found in soil and water or in decaying vegetation. While Aspergillus is entirely harmless for mos...
--PARENT--> [?] Mycoses
--- Walk 6 ---
[1F20.Z] Aspergillosis, unspecified
--PARENT--> [1F20] Aspergillosis
Def: Aspergillosis is a disease caused by fungi of the genus Aspergillus. The organism is ubiquitous, being found in soil and water or in decaying vegetation. While Aspergillus is entirely harmless for mos...
--RELATED_TO--> [?] Aspergillus-induced allergic or hypersensitivity conditions
|
[
"[2E88] Benign endometrial stromal nodule\n --PARENT--> [?] Benign mesenchymal neoplasms\n Def: Bening neoplasms of muscle, fat, fibrous tissue, bone, cartilage, and blood vessels....\n --CHILD--> [2E81] Benign vascular neoplasms",
"[2E88] Benign endometrial stromal nodule\n --PARENT--> [?] Benign mesenchymal neoplasms\n Def: Bening neoplasms of muscle, fat, fibrous tissue, bone, cartilage, and blood vessels....\n --CHILD--> [2E82] Benign chondrogenic tumours",
"[FA20.0] Seropositive rheumatoid arthritis\n --PARENT--> [FA20] Rheumatoid arthritis\n Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...\n --CHILD--> [FA20.1] Seronegative rheumatoid arthritis",
"[FA20.0] Seropositive rheumatoid arthritis\n --PARENT--> [FA20] Rheumatoid arthritis\n Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...\n --EXCLUDES--> [?] Acute rheumatic fever\n Def: A disease of the connective tissue, caused by an infection with the gram-positive bacteria Streptococcus pyogenes (the disease may also affect the heart, joints, central nervous system, subcutaneous t...",
"[1F20.Z] Aspergillosis, unspecified\n --PARENT--> [1F20] Aspergillosis\n Def: Aspergillosis is a disease caused by fungi of the genus Aspergillus. The organism is ubiquitous, being found in soil and water or in decaying vegetation. While Aspergillus is entirely harmless for mos...\n --PARENT--> [?] Mycoses",
"[1F20.Z] Aspergillosis, unspecified\n --PARENT--> [1F20] Aspergillosis\n Def: Aspergillosis is a disease caused by fungi of the genus Aspergillus. The organism is ubiquitous, being found in soil and water or in decaying vegetation. While Aspergillus is entirely harmless for mos...\n --RELATED_TO--> [?] Aspergillus-induced allergic or hypersensitivity conditions"
] |
2E88
|
Benign endometrial stromal nodule
|
[
{
"from_icd11": "FA20.0",
"icd10_code": "M0569",
"icd10_title": "Rheumatoid arthritis of multiple sites with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0579",
"icd10_title": "Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M05612",
"icd10_title": "Rheumatoid arthritis of left shoulder with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0570",
"icd10_title": "Rheumatoid arthritis with rheumatoid factor of unspecified site without organ or systems involvement"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0560",
"icd10_title": "Rheumatoid arthritis of unspecified site with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0500",
"icd10_title": "Felty's syndrome, unspecified site"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0639",
"icd10_title": "Rheumatoid nodule, multiple sites"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0630",
"icd10_title": "Rheumatoid nodule, unspecified site"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M05",
"icd10_title": "Rheumatoid arthritis with rheumatoid factor"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M050",
"icd10_title": "Felty's syndrome"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M063",
"icd10_title": "Rheumatoid nodule"
},
{
"from_icd11": "1F20.Z",
"icd10_code": "B4489",
"icd10_title": "Other forms of aspergillosis"
},
{
"from_icd11": "1F20.Z",
"icd10_code": "B4481",
"icd10_title": "Allergic bronchopulmonary aspergillosis"
},
{
"from_icd11": "1F20.Z",
"icd10_code": "B441",
"icd10_title": "Other pulmonary aspergillosis"
},
{
"from_icd11": "1F20.Z",
"icd10_code": "B449",
"icd10_title": "Aspergillosis, unspecified"
}
] |
M0569
|
Rheumatoid arthritis of multiple sites with involvement of other organs and systems
|
An 8-year-old previously healthy boy was referred to the pediatric rheumatology center of Kerman University, in Southeast of Iran, for left side lower extremity gait disturbance and limping. This condition had appeared three weeks prior to his visit and he did not have any history of trauma or vigorous activity. However, he had experienced mild respiratory tract infection including low-grade fever and cough approximately one week before refusing to walk. During this time, he had visited an orthopedist. However, his condition was not diagnosed in that visit. Finally, he was referred to our clinic for more evaluations. At the time of his first visit, the patient did not have a fever. We performed a complete and systematic examination. He had an antalgic gait at his left side due to difficulty in weight bearing. His physical examination revealed pain and limitation in flexion, internal and external rotational movements of left hip with a positive FABER Test. There was not any evidence of other contributing factors and red flags, including organomegaly, lymphadenopathy, skin lesions, and neurological deficits. His laboratory evaluations revealed a White Blood Cell (WBC) count of 9 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\times$$\end{document} × 10 9 /L with an Absolute Neutrophil Count (ANC) of 3.2 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\times$$\end{document} × 10 9 /L and an Absolute Lymphocyte Count (ALC) of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$4.64\times$$\end{document} 4.64 × 10 9 /L, a platelet count of 312,000/µL, and a hemoglobin of 15.5 g/dl. The Erythrocyte Sediment Rate (ESR) and C-Reactive Protein (CRP) were 3mm/h and 3.5 mg/L, respectively (Table 1 ). Considering the preceding symptoms of fever and cough, a serological investigation for both IgM and IgG of SARS-CoV-2 infection was performed. The tests indicated a high IgM level of 3.4 (with a 1.1 cut off) in the first test, and a high IgG level of 3.8 (with a 1.1 cut off) in the second test, which was performed one week later. Detection of SARS-CoV-2 antibodies was performed using SARS-CoV-2 immunoglobulin M (IgM) ELISA kits (Pishtaz Teb, Iran, http://pishtazteb.com ) and SARS-CoV-2 IgG ELISA kits (Pishtaz Teb, Iran http://pishtazteb.com ) according to the manufacturer’s protocol (Specificity: 97.30 %; Sensitivity: 79.40 %) . The nasopharyngeal swab for coronavirus Polymerase Chain Reaction (PCR) assay was not tested due to latency evaluation from preceding symptoms and patient’s parents refusal. There was not any evidence of marked joint space widening, reactive bone and fatty changes and other pathologic findings in his hip X-Ray. In addition, his chest radiography was normal. He underwent hip joints ultrasound study with a result of 7mm effusion in left side. Finally, Magnetic Resonance Imaging (MRI) showed a moderate joint effusion at his left hip articulation and a minimal joint effusion at his right hip joint . Treatment was administered by skin traction and Naproxen 250 mg twice a day. The patient consequently recovered approximately one week later without any issues with either hip movement restriction or gait pattern and mobility. Table 1 The Laboratory finding of both patients at the time of limp. The acute phase reactant of both patient were in normal range after 1 week Laboratory Test Case-1 Case-2 WBC(5-14.5)10*3/µL 9.3 9.7 RBC(3.9–5.3)10*6/ µL 6.16 4.11 ANC 3255 5600 ALC 5700 2650 Hb (11.5–15.5 g/dl) 15.9 11.9 MCV(75–87 fL) 75.6 82 Platelet(172–450)10*3/ µL 310 511 ESR(0–15 mm/h) 7.0 39.0 CRP(0–10 mg/l) 13.0 12.0 PBS for blast Negative Negative BUN 10 7 Cr (0.5-1 mg/dl) 0.5 0.6 AST (5–60 IU/ml) 24 23 ALT (6–50 IU/ml) 17 12 ALP (180–1200 IU/ml 558 339 Ferritin(11–92 ng/ml) N.A 49.30 LDH (< 746 U/L) 385 409 Uric Acid (3-6.4 mg/dl) 2.1 N.A Wright Agglutination Test Negative Negative 2ME Negative Negative Coombs Wright Negative Negative ASO-Titer (up to 200 IU/ml) 62 31 ANA (IU/ml) Negative (0.2) Negative RF (< 16 IU/ml) 27 Negative Coronavirus IgM (< 1.1)* Indirect ELISA 3.8 1.2 Coronavirus IgG (< 1.1)** Indirect ELISA 3.4 0.35 Coronavirus PCR N.A Positive * & **: Detection of SARS-CoV-2 antibodies was performed using SARS-CoV-2 immunoglobulin M (IgM) ELISA kits (Pishtaz Teb, Iran, http://pishtazteb.com ) and SARS-CoV-2 IgG ELISA kits (Pishtaz Teb, Iran http://pishtazteb.com ) according to the manufacturer’s protocol. Pishtaz Teb Zaman diagnostic Kits (Specificity: 97.30 %; Sensitivity: 79.40 %) Fig. 1 STIR sequencing MRI of both hip joints of the first patients. a-b Coronal view. c Axial view. d Sagittal view. Both hip joints effusion, especially in left side
| 4.023438
| 0.976074
|
sec[1]/sec[0]/p[0]
|
en
| 0.999995
|
34118941
|
https://doi.org/10.1186/s12969-021-00555-9
|
[
"usepackage",
"sars",
"document",
"elisa",
"iran",
"both",
"kits",
"pishtaz",
"side",
"count"
] |
[
{
"code": "1D65",
"title": "Severe acute respiratory syndrome"
},
{
"code": "RA01.0",
"title": "COVID-19, virus identified"
},
{
"code": "RA01.0/CA40.1Z",
"title": "COVID-19 with pneumonia, SARS-CoV-2 identified"
},
{
"code": "RA01.1/CA40.1Z",
"title": "COVID-19 with pneumonia, SARS-CoV-2 not identified"
},
{
"code": "PL14.7",
"title": "Problem associated with clinical documentation"
},
{
"code": "QA87",
"title": "Problem with clinical documentation without injury or harm"
},
{
"code": "QA50",
"title": "Embolisation without injury or harm"
},
{
"code": "QA89",
"title": "Incorrect diagnosis without injury or harm"
},
{
"code": "QA63",
"title": "Obstruction of device without injury or harm"
},
{
"code": "LB99.6",
"title": "Acheiria"
}
] |
=== ICD-11 CODES FOUND ===
[1D65] Severe acute respiratory syndrome
Definition: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to pneumonia. Transmission is by direct contact, inhalation of infected respiratory secretions, or airborne transmission. Confirmation is by identification of coronavirus in a blood, stool, respiratory secretions, or body tissue sample.
Also known as: Severe acute respiratory syndrome | SARS - [severe acute respiratory syndrome]
Excludes: COVID-19, virus identified | COVID-19, virus not identified
[RA01.0] COVID-19, virus identified
Also known as: COVID-19, virus identified | 2019-new Coronavirus acute respiratory disease (deprecated) | 2019-nCoV acute respiratory disease [temporary name] (deprecated) | Coronavirus disease 2019 | SARS-CoV-2 disease
Includes: Coronavirus disease 2019 | COVID-19 NOS
Excludes: Coronavirus infection, unspecified site | Middle East respiratory syndrome | Severe acute respiratory syndrome
[PL14.7] Problem associated with clinical documentation
Definition: Clinical documentation error or omission led to injury of patient
Also known as: Problem associated with clinical documentation
[QA87] Problem with clinical documentation without injury or harm
Definition: Documentation on wrong patient; incomplete documentation; incorrect documentation identified as inconsistent with other source, but without documented injury or harm to the patient.
Also known as: Problem with clinical documentation without injury or harm | documentation on wrong patient without documented injury or harm | incomplete documentation without documented injury or harm | incorrect documentation identified as inconsistent with other source without documented injury or harm
Excludes: Problem associated with clinical documentation
[QA50] Embolisation without injury or harm
Definition: An embolisation without documented injury or harm occurs when a solid object within the venous or arterial circulation propagates to a distal location and becomes lodged there.
Also known as: Embolisation without injury or harm | Embolic phenomenon without documented injury or harm | Air embolism without documented injury or harm | Injection of air without injury or harm
Excludes: Embolisation, as mode of injury or harm
[QA89] Incorrect diagnosis without injury or harm
Definition: Diagnosis changed after further study and as a result, treatment was incorrect; misdiagnosis; conflicting diagnoses
Also known as: Incorrect diagnosis without injury or harm | conflicting diagnoses without documented injury or harm | misdiagnosis without documented injury or harm
Excludes: Incorrect diagnosis
[QA63] Obstruction of device without injury or harm
Definition: A device that has become obstructed or blocked but without any documented injury or harm.
Also known as: Obstruction of device without injury or harm | Blockage of device without documented injury or harm | Blocked tube causing obstruction without documented injury or harm | Occlusion of device without documented injury or harm | Thrombosis of device without documented injury or harm
Excludes: Obstruction of device, as mode of injury or harm
[LB99.6] Acheiria
Definition: A condition caused by failure of one or both hands to develop during the antenatal period.
Also known as: Acheiria | Congenital absence of hand | agenesis of hand | congenital absence of hand and finger | congenital absence of hand and wrist
=== GRAPH WALKS ===
--- Walk 1 ---
[1D65] Severe acute respiratory syndrome
Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...
--EXCLUDES--> [?] COVID-19, virus identified
--CHILD--> [?] COVID-19 with pneumonia, SARS-CoV-2 identified
--- Walk 2 ---
[1D65] Severe acute respiratory syndrome
Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...
--EXCLUDES--> [?] COVID-19, virus not identified
--EXCLUDES--> [?] COVID-19, virus identified
--- Walk 3 ---
[RA01.0] COVID-19, virus identified
--EXCLUDES--> [?] Middle East respiratory syndrome
Def: A disease caused by an infection with Middle East Respiratory Syndrome coronavirus (MERS-CoA). This disease is characterised by severe acute respiratory illness with fever, cough, and shortness of bre...
--PARENT--> [?] Certain zoonotic viral diseases
--- Walk 4 ---
[RA01.0] COVID-19, virus identified
--EXCLUDES--> [?] Coronavirus infection, unspecified site
--EXCLUDES--> [?] Severe acute respiratory syndrome
Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...
--- Walk 5 ---
[PL14.7] Problem associated with clinical documentation
Def: Clinical documentation error or omission led to injury of patient...
--PARENT--> [PL14] Mode of injury or harm associated with other health care related causes
--EXCLUDES--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--- Walk 6 ---
[PL14.7] Problem associated with clinical documentation
Def: Clinical documentation error or omission led to injury of patient...
--PARENT--> [PL14] Mode of injury or harm associated with other health care related causes
--EXCLUDES--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
|
[
"[1D65] Severe acute respiratory syndrome\n Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...\n --EXCLUDES--> [?] COVID-19, virus identified\n --CHILD--> [?] COVID-19 with pneumonia, SARS-CoV-2 identified",
"[1D65] Severe acute respiratory syndrome\n Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...\n --EXCLUDES--> [?] COVID-19, virus not identified\n --EXCLUDES--> [?] COVID-19, virus identified",
"[RA01.0] COVID-19, virus identified\n --EXCLUDES--> [?] Middle East respiratory syndrome\n Def: A disease caused by an infection with Middle East Respiratory Syndrome coronavirus (MERS-CoA). This disease is characterised by severe acute respiratory illness with fever, cough, and shortness of bre...\n --PARENT--> [?] Certain zoonotic viral diseases",
"[RA01.0] COVID-19, virus identified\n --EXCLUDES--> [?] Coronavirus infection, unspecified site\n --EXCLUDES--> [?] Severe acute respiratory syndrome\n Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...",
"[PL14.7] Problem associated with clinical documentation\n Def: Clinical documentation error or omission led to injury of patient...\n --PARENT--> [PL14] Mode of injury or harm associated with other health care related causes\n --EXCLUDES--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance",
"[PL14.7] Problem associated with clinical documentation\n Def: Clinical documentation error or omission led to injury of patient...\n --PARENT--> [PL14] Mode of injury or harm associated with other health care related causes\n --EXCLUDES--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance"
] |
1D65
|
Severe acute respiratory syndrome
|
[
{
"from_icd11": "1D65",
"icd10_code": "U04",
"icd10_title": ""
},
{
"from_icd11": "1D65",
"icd10_code": "U049",
"icd10_title": ""
},
{
"from_icd11": "QA87",
"icd10_code": "XXI",
"icd10_title": ""
},
{
"from_icd11": "LB99.6",
"icd10_code": "Q7131",
"icd10_title": "Congenital absence of right hand and finger"
},
{
"from_icd11": "LB99.6",
"icd10_code": "Q7133",
"icd10_title": "Congenital absence of hand and finger, bilateral"
},
{
"from_icd11": "LB99.6",
"icd10_code": "Q7130",
"icd10_title": "Congenital absence of unspecified hand and finger"
},
{
"from_icd11": "LB99.6",
"icd10_code": "Q713",
"icd10_title": "Congenital absence of hand and finger"
}
] |
U04
| |
A 42-year-old man with a cardiac tamponade was referred to the Department of Cardiovascular Surgery of our hospital to be submitted to an urgent pericardiotomy following a median sternotomy. His medical history dated back to July 2006 when he was admitted to the Cardiological Department of General Hospital in a suburb of Florence, complaining of a three-week history of chest pain and dyspnea. On admission, the patient was in good general condition. Blood pressure (BP) and pulse were normal. Heart auscultation was unremarkable except for a faint pericardial rub; chest examination showed normal breath sounds. Blood tests showed hemoglobin 11.5 g/dl, leukocyte count 7000/mm 3 , platelet count 250 × 10 3 /mm 3 ; liver and renal biochemistry, clotting profile, and erythrocyte sedimentation rate (ESR) were normal. At this time chest X-ray showed a mild cardiomegaly. An electrocardiogram (EKG) showed normal sinus rhythm without acute ischemic alterations. Subsequently, he was submitted to transthoracic echocardiography (TTE) that documented a voluminous pericardial effusion with normal left ventricular function. The patient was treated with pericardiocentesis, and a total of 1500 cc of hemorrhagic pericardial fluid was aspirated. Laboratory and cytological analysis of the pericardial fluid resulted negative for malignancy. After a complete diagnostic work-up he was diagnosed as having acute pericarditis (of likely viral origin) and he was discharged in good condition from the hospital for follow-up and ambulatory investigation. A month after discharge, the patient returned to the emergency room of our hospital with a second episode of chest pain, rapidly progressive dyspnea, hypotension, and tachycardia. The TTE confirmed the clinical suspect of recurrent pericardial effusion complicated by a cardiac tamponade. Then it was necessary to again perform an emergency pericardiocentesis with aspiration of 70 cc alone of hemorrhagic pericardial fluid and to refer the patient to the Department of Cardiovascular Surgery. The patient underwent an urgent operation consisting in a median sternotomy and longitudinal pericardiotomy. During the operation a tumoral tissue was found covering the surface of the right atrium and most of the anterolateral pericardium. The tumor was then partially excised. The histological examination revealed the presence of a moderately differentiated angiosarcoma. The histological features of the neoplasm were quite variable among the different zones of the lesion. At low power, the tumor showed an alternation of hyper- and hypocellular areas with the presence of dense keloid-type collagen alternating to myxoid areas ( Figure 1(a) ). Due to these features, on frozen section examination, the hypothesis of solitary fibrous tumor was raised. In areas, the tumor was virtually avascular and composed of compact masses of moderately pleomorphic spindled and epithelioid cells within a collagenous stroma. In other areas, the neoplasm showed clusters of small and short capillary-like slits, sometimes in stellate configuration, lined with variably atypical tumor cells ( Figure 1(b) ). In other portions, the tumor displayed large, well-formed, but irregularly contoured vascular spaces in continuity with small sinusoidal-type tributaries or a relatively pure sinusoidal vascular pattern, often intersected by broad collagenous bands. The immunohistochemical investigation documented that tumor cells were positive for CD31 ( Figure 1(c) ), CD34 ( Figure 1(d) ), Von Willebrand Factor (VWF) ( Figure 1(e) ), and about 60% of them were positive for Mib-1 ( Figure 1(f) ), whereas they were negative for EMA, bcl-2, smooth muscle actin, common muscle actin, desmin, and protein S-100. The patient was moved to the Department of Internal Medicine in our hospital. At that time, hemodynamic parameters were stable, chest X-ray showed cardiomegaly and left-sided pleural effusion and TTE detected only a small pericardial effusion with normal cardiac size and ventricular function (ejection fraction, evaluated with TTE, was 63%). A further evaluation with cardiac magnetic resonance imaging (MRI) showed a large mass (53 mm) extending from the free wall of the right atrium to the anterior mediastinum beside the superior vena cava and ascending aorta, above up to the right pulmonary artery, clearly revealed irregular signals in the mass after gadolinium enhancement . The extensive study using computed tomography (CT) of the brain, chest and abdomen and positron emission tomography (PET) showed no metastasis. The patient was then referred to our oncology unit and scheduled for a chemotherapeutic regimen including Epirubicin (EPI) (60 mg/m 2 , on days 1 and 2) plus Ifosfamide (IFO) and Uromitexan . All drugs were administered every three weeks. After two cycles, a restaging work-up with CT plus PET and cardiac MRI revealed a partial response. The treatment was well tolerated and continued for another two cycles. A new evaluation by cardiac MRI and total body CT evidenced a local progression of disease and appearance of pulmonary metastases. The patient died after three months for occurrence of acute respiratory failure.
| 4.066406
| 0.972656
|
sec[0]/p[0]
|
en
| 0.999995
|
19724650
|
https://doi.org/10.1155/2009/591512
|
[
"pericardial",
"tumor",
"cardiac",
"chest",
"department",
"effusion",
"areas",
"three",
"that",
"fluid"
] |
[
{
"code": "BB2Z",
"title": "Pericarditis, unspecified"
},
{
"code": "LA8D",
"title": "Congenital pericardial anomaly"
},
{
"code": "BB2Y",
"title": "Other specified pericarditis"
},
{
"code": "BB22",
"title": "Constrictive pericarditis"
},
{
"code": "GA10.E&XA2XU0",
"title": "Endometriosis of pericardium"
},
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
}
] |
=== ICD-11 CODES FOUND ===
[BB2Z] Pericarditis, unspecified
Also known as: Pericarditis, unspecified | pericarditis NOS | pericardial inflammation | pericardium inflammation
[LA8D] Congenital pericardial anomaly
Definition: A congenital cardiovascular malformation in which there is a structural and/or functional abnormality of the pericardium.
Also known as: Congenital pericardial anomaly | malformations of pericardium | structural developmental anomalies of the pericardium | congenital anomaly of pericardium | structural developmental anomaly of the pericardium
[BB2Y] Other specified pericarditis
Also known as: Other specified pericarditis | Certain diseases of pericardium | Chronic adhesive pericarditis | adherent pericarditis | adherent pericardium
[BB22] Constrictive pericarditis
Definition: Chronic fibrous pericarditis due to the presence of dense fibrous tissue between the parietal and visceral layers of pericardium and neighbouring structures.
Also known as: Constrictive pericarditis | pericarditis calculosa | Hutinel-Pick syndrome | chronic tamponade | chronic pericardial constriction
Includes: concretio cordis
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[BB2Z] Pericarditis, unspecified
--PARENT--> [?] Pericarditis
--PARENT--> [11] Diseases of the circulatory system
Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...
--- Walk 2 ---
[BB2Z] Pericarditis, unspecified
--PARENT--> [?] Pericarditis
--CHILD--> [BB21] Chronic rheumatic pericarditis
Def: Inflammation of the pericardium and of the surrounding mediastinal cellular tissue resulted from rheumatic etiology....
--- Walk 3 ---
[LA8D] Congenital pericardial anomaly
Def: A congenital cardiovascular malformation in which there is a structural and/or functional abnormality of the pericardium....
--PARENT--> [?] Structural developmental anomaly of heart or great vessels
Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....
--CHILD--> [LA80] Anomalous position-orientation of heart
Def: A congenital cardiovascular finding or malformation in which there is an abnormality of the position or orientation of heart....
--- Walk 4 ---
[LA8D] Congenital pericardial anomaly
Def: A congenital cardiovascular malformation in which there is a structural and/or functional abnormality of the pericardium....
--PARENT--> [?] Structural developmental anomaly of heart or great vessels
Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....
--RELATED_TO--> [?] Congenital great vessel related acquired abnormality
Def: Any postnatal pathological change in form or function of the heart and/or great vessels consequent to the presence of congenital cardiovascular disease....
--- Walk 5 ---
[BB2Y] Other specified pericarditis
--PARENT--> [?] Pericarditis
--CHILD--> [BB21] Chronic rheumatic pericarditis
Def: Inflammation of the pericardium and of the surrounding mediastinal cellular tissue resulted from rheumatic etiology....
--- Walk 6 ---
[BB2Y] Other specified pericarditis
--PARENT--> [?] Pericarditis
--CHILD--> [BB20] Acute pericarditis
Def: Acute pericarditis is defined as pericardial inflammation of no more than 1 to 2 weeks duration....
|
[
"[BB2Z] Pericarditis, unspecified\n --PARENT--> [?] Pericarditis\n --PARENT--> [11] Diseases of the circulatory system\n Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...",
"[BB2Z] Pericarditis, unspecified\n --PARENT--> [?] Pericarditis\n --CHILD--> [BB21] Chronic rheumatic pericarditis\n Def: Inflammation of the pericardium and of the surrounding mediastinal cellular tissue resulted from rheumatic etiology....",
"[LA8D] Congenital pericardial anomaly\n Def: A congenital cardiovascular malformation in which there is a structural and/or functional abnormality of the pericardium....\n --PARENT--> [?] Structural developmental anomaly of heart or great vessels\n Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....\n --CHILD--> [LA80] Anomalous position-orientation of heart\n Def: A congenital cardiovascular finding or malformation in which there is an abnormality of the position or orientation of heart....",
"[LA8D] Congenital pericardial anomaly\n Def: A congenital cardiovascular malformation in which there is a structural and/or functional abnormality of the pericardium....\n --PARENT--> [?] Structural developmental anomaly of heart or great vessels\n Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....\n --RELATED_TO--> [?] Congenital great vessel related acquired abnormality\n Def: Any postnatal pathological change in form or function of the heart and/or great vessels consequent to the presence of congenital cardiovascular disease....",
"[BB2Y] Other specified pericarditis\n --PARENT--> [?] Pericarditis\n --CHILD--> [BB21] Chronic rheumatic pericarditis\n Def: Inflammation of the pericardium and of the surrounding mediastinal cellular tissue resulted from rheumatic etiology....",
"[BB2Y] Other specified pericarditis\n --PARENT--> [?] Pericarditis\n --CHILD--> [BB20] Acute pericarditis\n Def: Acute pericarditis is defined as pericardial inflammation of no more than 1 to 2 weeks duration...."
] |
BB2Z
|
Pericarditis, unspecified
|
[
{
"from_icd11": "BB2Z",
"icd10_code": "I314",
"icd10_title": "Cardiac tamponade"
},
{
"from_icd11": "BB2Z",
"icd10_code": "I319",
"icd10_title": "Disease of pericardium, unspecified"
},
{
"from_icd11": "BB2Z",
"icd10_code": "I310",
"icd10_title": "Chronic adhesive pericarditis"
},
{
"from_icd11": "BB2Z",
"icd10_code": "I318",
"icd10_title": "Other specified diseases of pericardium"
},
{
"from_icd11": "BB2Z",
"icd10_code": "I31",
"icd10_title": "Other diseases of pericardium"
},
{
"from_icd11": "LA8D",
"icd10_code": "Q248",
"icd10_title": "Other specified congenital malformations of heart"
},
{
"from_icd11": "BB22",
"icd10_code": "I311",
"icd10_title": "Chronic constrictive pericarditis"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
}
] |
I314
|
Cardiac tamponade
|
A 48-year-old female with a history of kidney transplantation 15 years before the immunosuppressive treatment with cyclosporine, Cellcept, and mycophenolate mofetil (MMF) PO 500 mg twice daily (BID), was known to have hypertension (HTN) for 20 years and diabetes mellitus for 5 years who was under treatment with insulin injection. The patient also had a deep vein thrombosis (DVT) in the lower limb, which was treated with oral rivaroxaban 15 mg daily for three months. She got a COVID-19 infection confirmed by RT-PCR test. She was admitted to a small rural hospital and treated with four doses of dexamethasone (4 mg/twice daily/IV) and remdesivir (100 mg/daily/four days). Likewise, she was hospitalized two months after recovering from COVID-19 with a skin lesion on her right arm. Based on the appearance of the lesion, a prior intravascular device adhesive site-related process was suggested. The lesion appeared as an erythematous area and gradually enlarged into a violaceous plaque measuring 5 mm in diameter. The lesion was misdiagnosed as a bacterial infection and the treatment she received included meropenem 500 mg every 12 hours, and vancomycin 1 gr every day. Although the wound was regularly washed out and dressed, it progressed to a necrotizing ulcer with tissue invasion and failed to respond to the initial treatment. She was discharged without considerable relief. Two weeks after the prior admission, she was referred to our medical emergency center with a new skin lesion on the anterior side of the right forearm. Physical examination showed a dark red irregular plaque with a purulent effusion combined with a hemorrhagic keratotic eschar in size of 7 cm in diameter . The patient was febrile (39 Celsius degrees) and had numbness without enlarged lymph nodes in her right hand on admission and pitting edema of the lower limbs. She denied any trauma or injury to the right arm. Clinically, the lesion was an extensive deep invasion of the tissue which seemed to follow a venous track to the forearm. Laboratory examination results were as follows: white cell count of 15.6 leukocytes/mm3 with 88.6% neutrophils and 8.4% lymphocytes and her platelet count was 300 × 103/mcl. Hemoglobin: 9.9 g/dL, C-reactive protein: 80 mg/L, ESR: 92 mm/1 h, creatinine: 1.6 μmol/L, albumin 1.9 g/L, FBS: 340 mmol/L with HbA1c: 9.1%, urea: 117 mg/dL, ferritin: 674 μg/L, total bilirubin: 0.46 mg/dL and International Normalized Ratio (INR) of 1.71. Urine analysis showed 3+ proteinuria, +3 glucose, 2-3 red blood cells (RBCs)/HP, and 3-4 pus cells/high-power field (HPF). X-ray examination revealed subcutaneous skin thickening with extension into the muscular tissue without bony abnormality . The pitting edema index of her lower limb values were +1 on the right and +2 on the left. Eco-Doppler displayed the existence of hyperechogenic subcutaneous tissue. The forearm ulcer was expanding with central necrosis that required surgical debridement. The initial sample obtained was sent for histopathologic and microbiologic examination . Based on the aggressive clinical behavior of the lesion and the clinical suspicion of the fungus, an intravenous liposomal amphotericin B (AmB) (5 mg/kg/day) injection was started empirically after the first debridement. Direct examination with potassium hydroxide (KOH) and hematoxylin and eosin (H&E) staining revealed similar features including broad non-septated hyphae with irregular wide-angle branches . The culture of the eschar on Sabouraud dextrose agar medium at 25˚C and 37˚C showed growth of the fluffy grayish-white colonies. Molecular analysis was achieved by 18S ITS1-5.8S-ITS2-28S region of the ribosomal DNA amplification and sequencing using the universal primers ITS1-ITS4. The consensus sequence homology was checked and compared with the GenBank database (https://www.blast.ncbi.nlm.nih.gov/ Blast. cgi). The isolated pathogen was identified as Rhizopus oryzae. According to the CLSI-M38A2 guidelines, antifungal susceptibility testing was performed. The minimum inhibitory concentrations (MICs) were as follows: amphotericin B (1 µg/mL), posaconazole (6.5 µg/mL), voriconazole (8 µg/mL), and itraconazole (2 µg/mL). The possibility of dissemination of mucormycosis was evaluated by computed tomography (CT) imaging of the sinus, chest, and abdomen, and the evidence suggestive of rhinocerebral region and pulmonary region involvement was not found. Assessment with electromyography and nerve conduction analysis revealed myopathy illness. To avoid progression of the threatening infection, cellcept was stopped and cyclosporine was tapered to 25 mg every 12 hours. The patient had several predisposing factors including diabetes mellitus, hypertension, deep vein thrombosis (DVT), prolonged steroid use, and transplanted kidney insufficiency with increased levels of creatinine. Thirty days after admission, esophagogastroduodenoscopy (EGD) reported gastrointestinal bleeding (GIB). We thought that all these factors played roles in the worsening of hemodynamic state and cutaneous mucormycosis. Unfortunately, the patient died after a 32-day hospital stay. The time course of the patient is described in Figure 5 .
| 3.951172
| 0.980957
|
sec[1]/p[0]
|
en
| 0.999998
|
PMC11304458
|
https://doi.org/10.30699/IJP.2024.2006768.3143
|
[
"lesion",
"daily",
"tissue",
"infection",
"skin",
"every",
"without",
"forearm",
"region",
"kidney"
] |
[
{
"code": "FA5Z",
"title": "Arthropathies, unspecified"
},
{
"code": "FC0Z",
"title": "Diseases of the musculoskeletal system or connective tissue, unspecified"
},
{
"code": "ME60.Z",
"title": "Skin lesion of unspecified nature"
},
{
"code": "MD41",
"title": "Clinical findings on diagnostic imaging of lung"
},
{
"code": "GC2Z&XA6KU8",
"title": "Disease of kidney, not elsewhere classified"
},
{
"code": "QF21",
"title": "Difficulty or need for assistance with general life tasks or life management"
},
{
"code": "8A83",
"title": "Other primary headache disorder"
},
{
"code": "QB42",
"title": "Dependence on renal dialysis"
},
{
"code": "FB6Z",
"title": "Soft tissue disorders, unspecified"
},
{
"code": "MC85",
"title": "Gangrene"
}
] |
=== ICD-11 CODES FOUND ===
[FA5Z] Arthropathies, unspecified
Also known as: Arthropathies, unspecified | Disorders affecting predominantly peripheral joints | Disorders affecting predominantly peripheral limb joints | arthropathy NOS | arthropathic
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
Also known as: Diseases of the musculoskeletal system or connective tissue, unspecified | bone disease NOS | bone disorder NOS | bone lesion NOS | musculoskeletal complications NOS
[ME60.Z] Skin lesion of unspecified nature
Also known as: Skin lesion of unspecified nature | Skin lesion of uncertain or unspecified nature | Skin lesion without established diagnosis | Pigmented skin lesion of unspecified nature | Ulcer of skin of unspecified nature
[MD41] Clinical findings on diagnostic imaging of lung
Definition: Clinical findings on diagnostic imaging of lung is findings on diagnostic imaging of the lung which don't appear in normal status of the body. Diagnostic imaging refers to technologies that doctors use to look inside body for clues about a medical condition. X-rays, CT scans, nuclear medicine scans, MRI scans and ultrasound are all types of diagnostic imaging.
Also known as: Clinical findings on diagnostic imaging of lung | abnormal diagnostic imaging of lung | Hyperinflation of lung | Lung mass | Pulmonary lobe mass
[QF21] Difficulty or need for assistance with general life tasks or life management
Also known as: Difficulty or need for assistance with general life tasks or life management | difficulty with carrying out tasks and daily routine | life management problem | difficulty with life management tasks | Difficulty with dealing with change such as relocation
Includes: difficulty with carrying out tasks and daily routine
[8A83] Other primary headache disorder
Definition: A group of clinically heterogeneous headache disorders, believed to be primary. Although largely unrelated, they fall into four categories: headaches associated with physical exertion; headaches attributed to direct physical but innocuous stimuli; epicranial headaches; and other miscellaneous primary headache disorders.
Also known as: Other primary headache disorder | Primary cough headache | Primary exercise headache | Primary headache associated with sexual activity | Preorgasmic headache
[QB42] Dependence on renal dialysis
Also known as: Dependence on renal dialysis | renal dialysis status | presence of arteriovenous shunt for dialysis | dependence on haemodialysis | Dependence on renal dialysis, acute haemodialysis
Includes: renal dialysis status
Excludes: dialysis preparation, treatment or session
[FB6Z] Soft tissue disorders, unspecified
Also known as: Soft tissue disorders, unspecified | disease of soft tissue NOS | unspecified soft tissue disorder, site unspecified | disorder of soft tissue | disorder of soft tissue NOS
[MC85] Gangrene
Definition: Gangrene, not elsewhere classified is the death of tissues in the body which happens when a part of the body loses its blood supply.
Also known as: Gangrene | gangrene NOS | dry gangrene | wet gangrene | ulcerative gangrene
Excludes: Pyoderma gangrenosum | Gas gangrene | Polymicrobial necrotising fasciitis
=== GRAPH WALKS ===
--- Walk 1 ---
[FA5Z] Arthropathies, unspecified
--PARENT--> [?] Arthropathies
--CHILD--> [?] Infection related arthropathies
Def: A disease of the joints, caused by an infection with a bacterial, viral, fungal, or parasitic source.
Distinction is made between the following types of etiological relationship.
a) direct infection ...
--- Walk 2 ---
[FA5Z] Arthropathies, unspecified
--PARENT--> [?] Arthropathies
--CHILD--> [?] Osteoarthritis
Def: Osteoarthritis (OA) can be defined as a group of distinct, but overlapping diseases, which may have different etiologies, but similar biological, morphological, and clinical outcomes affecting the art...
--- Walk 3 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--RELATED_TO--> [?] Monogenic autoinflammatory syndromes
Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....
--- Walk 4 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--RELATED_TO--> [?] Monogenic autoinflammatory syndromes
Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....
--- Walk 5 ---
[ME60.Z] Skin lesion of unspecified nature
--PARENT--> [ME60] Skin lesion of uncertain or unspecified nature
Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...
--CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature
Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made....
--- Walk 6 ---
[ME60.Z] Skin lesion of unspecified nature
--PARENT--> [ME60] Skin lesion of uncertain or unspecified nature
Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...
--CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature
Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made....
|
[
"[FA5Z] Arthropathies, unspecified\n --PARENT--> [?] Arthropathies\n --CHILD--> [?] Infection related arthropathies\n Def: A disease of the joints, caused by an infection with a bacterial, viral, fungal, or parasitic source.\n\nDistinction is made between the following types of etiological relationship.\na) direct infection ...",
"[FA5Z] Arthropathies, unspecified\n --PARENT--> [?] Arthropathies\n --CHILD--> [?] Osteoarthritis\n Def: Osteoarthritis (OA) can be defined as a group of distinct, but overlapping diseases, which may have different etiologies, but similar biological, morphological, and clinical outcomes affecting the art...",
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --RELATED_TO--> [?] Monogenic autoinflammatory syndromes\n Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....",
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --RELATED_TO--> [?] Monogenic autoinflammatory syndromes\n Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....",
"[ME60.Z] Skin lesion of unspecified nature\n --PARENT--> [ME60] Skin lesion of uncertain or unspecified nature\n Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...\n --CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature\n Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made....",
"[ME60.Z] Skin lesion of unspecified nature\n --PARENT--> [ME60] Skin lesion of uncertain or unspecified nature\n Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...\n --CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature\n Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made...."
] |
FA5Z
|
Arthropathies, unspecified
|
[
{
"from_icd11": "FA5Z",
"icd10_code": "M00-M25",
"icd10_title": ""
},
{
"from_icd11": "FC0Z",
"icd10_code": "XIII",
"icd10_title": ""
},
{
"from_icd11": "ME60.Z",
"icd10_code": "L989",
"icd10_title": "Disorder of the skin and subcutaneous tissue, unspecified"
},
{
"from_icd11": "MD41",
"icd10_code": "R911",
"icd10_title": "Solitary pulmonary nodule"
},
{
"from_icd11": "MD41",
"icd10_code": "R91",
"icd10_title": "Abnormal findings on diagnostic imaging of lung"
},
{
"from_icd11": "QF21",
"icd10_code": "Z742",
"icd10_title": "Need for assistance at home and no other household member able to render care"
},
{
"from_icd11": "QF21",
"icd10_code": "Z600",
"icd10_title": "Problems of adjustment to life-cycle transitions"
},
{
"from_icd11": "8A83",
"icd10_code": "G44209",
"icd10_title": "Tension-type headache, unspecified, not intractable"
},
{
"from_icd11": "8A83",
"icd10_code": "G44221",
"icd10_title": "Chronic tension-type headache, intractable"
},
{
"from_icd11": "8A83",
"icd10_code": "G44229",
"icd10_title": "Chronic tension-type headache, not intractable"
},
{
"from_icd11": "8A83",
"icd10_code": "G44201",
"icd10_title": "Tension-type headache, unspecified, intractable"
},
{
"from_icd11": "8A83",
"icd10_code": "G44219",
"icd10_title": "Episodic tension-type headache, not intractable"
},
{
"from_icd11": "8A83",
"icd10_code": "G442",
"icd10_title": "Tension-type headache"
},
{
"from_icd11": "QB42",
"icd10_code": "Z992",
"icd10_title": "Dependence on renal dialysis"
},
{
"from_icd11": "FB6Z",
"icd10_code": "M60-M79",
"icd10_title": ""
}
] |
M00-M25
| |
A 32-year-old man was admitted to our hospital with appetite loss. He had a history of traumatic transverse cervical spinal cord injury at the C5 level due to suicide attempt at the age of 18. As a result of cervical spinal cord injury, he was paralyzed in the lower body. Contrast-enhanced computed tomography (CT) revealed a late-onset traumatic diaphragmatic hernia with strangulated ileum . The small intestine, transverse colon, and omentum were displaced into the left thoracic cavity, and some portions of these organs showed a decrease in blood flow. Left lung collapse and a compressed right lung with mediastinal shift were evident. The patient underwent emergency surgery. After replacing the incarcerated organs to their original positions, scattered areas of necrosis were identified in the small intestine, transverse colon, and omentum . By using interrupted sutures with non-absorbable 1–0 monofilament, the diaphragmatic orifice was closed. Wedge resection with primary closure was performed for the colonic necrosis in two places. Partial resection, 45 cm long, with end-to-end anastomosis was performed for the small intestine. The necrotic omentum was removed . In addition, a gastrostomy tube was placed since delayed initiation of oral intake was expected. The patient developed severe septic shock postoperatively. Treatment-resistant critical hypotension with non-compensatory tachycardia developed, likely due to parasympathetic nervous system damage related to the cervical spinal cord injury. On postoperative days (POD) 3 and 6, cardiac arrest occurred. Fortunately, he was rescued by cardiopulmonary resuscitation with administration of large doses of vasopressin and catecholamine. However, peripheral vasoconstriction, increased intra-abdominal pressure, and ischemia of the gastrointestinal tract developed, which resulted in colonic anastomotic leakage with diffuse peritonitis, abdominal wound dehiscence, and collapse of gastrostomy on POD 6 . The patient was unable to undergo surgical repair because of his poor general condition with continuing severe septic and neurogenic shock. Therefore, he underwent AVS through the open abdominal wound and it was the first procedure at the intensive care unit. The procedure of AVS was as follows: 1. the open wound and peritoneal cavity were rinsed with normal saline and necrotic and/or contaminated tissues were debrided ; 2. wound dressing materials (DUOACTIVE® ConvaTec, New Jersey, USA) for protecting healthy skin around the open wound were patched along the abdominal wound in piecemeal fashion so as to adjust dressing materials to the complicated shape of the wound ; 3. two drainage tubes with multiple side holes, up to 30 cm from the tip, were placed in the abdominal cavity through the open abdomen and the enteric contents were suctioned through the drainage tubes using a Continuous Suction Unit MERA Sacuum (Senko Medical Instrument Manufacturing CO, Tokyo, Japan) set to 50–75 mmHg continuous negative pressure; and 4) the entire wound was filled with saline-moistened gauzes and covered with polyurethane drape . The colonic anastomotic leakage showed gradual healing over the course of 2 months, followed by contraction and closure of wound dehiscence . Because the gastric fistula remained, a gastrostomy balloon catheter was placed through the gastric fistula. The patient resumed oral intake on POD 112 and left the hospital on POD 190 with the gastrostomy balloon catheter and without incisional hernia. Fig. 1 Contrast-enhanced computed tomography (CT). Images demonstrated the presence of a large diaphragmatic hernia, which allowed the small intestine, transverse colon, and omentum to herniate into the left chest. Portions of these herniated organs showed decreased blood flow. Collapse of the left lung and marked mediastinal shift to the right were apparent Fig. 2 Schemata of the operative findings. a Diaphragmatic hernia with strangulated ileus: scattered areas of necrosis in the small intestine (black arrow), transverse colon (white arrowheads), and omentum (black arrowhead) were evident. b The orifice of the diaphragmatic hernia was closed with interrupted sutures (1). The necrotic portions of the transverse colon (2) and small intestine (3) were resected and repaired. A gastrostomy was performed (4) Fig. 3 The open abdominal wound on postoperative day 6. Wound dehiscence with collapse of the colonic anastomosis (arrow) and gastrostomy (arrowhead) was recognized Fig. 4 Procedure for abdominal vacuum sealing. a The open wound and peritoneal cavity were washed with saline and necrotic and/or contaminated tissues were debrided. b Wound dressing materials were placed along the abdominal wound to protect healthy skin around the wound. c Two drainage tubes (arrows) with multiple side holes, up to 30 cm from the tip, were placed in the abdominal cavity through the open abdomen to drain the gastrointestinal contents. Gastrointestinal contents were suctioned through the drainage tubes with negative pressure. d The gastric fistula remained, but other gastrointestinal anastomotic leakages were healed. The gastrostomy balloon was inserted in the gastric fistula
| 3.916016
| 0.973633
|
sec[1]/p[0]
|
en
| 0.999997
|
29907107
|
https://doi.org/10.1186/s12893-018-0375-6
|
[
"wound",
"abdominal",
"gastrostomy",
"open",
"transverse",
"small",
"intestine",
"diaphragmatic",
"hernia",
"colon"
] |
[
{
"code": "MD11.5",
"title": "Dyspnoea"
},
{
"code": "NB32.3Z",
"title": "Injury of lung, unspecified"
},
{
"code": "NB91.1Z",
"title": "Injury of liver, unspecified"
},
{
"code": "NA01.Z&XA9T94",
"title": "Temporal wound"
},
{
"code": "ND56.1",
"title": "Open wound of unspecified body region"
},
{
"code": "MD81.3",
"title": "Acute abdomen"
},
{
"code": "JA01.0",
"title": "Abdominal pregnancy"
},
{
"code": "ME04.Z",
"title": "Ascites, unspecified"
},
{
"code": "NB51.0&XA3KX0",
"title": "Laceration without foreign body of abdominal wall"
},
{
"code": "NB9Y",
"title": "Other specified injuries to the abdomen, lower back, lumbar spine or pelvis"
}
] |
=== ICD-11 CODES FOUND ===
[MD11.5] Dyspnoea
Definition: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a presenting complaint of patients with a wide variety of medical diseases by multiple mechanisms.
Dyspnoea is considered acute when it lasts from hours up to 3 weeks, subacute from 3 weeks up to 8 weeks, and chronic dyspnoea lasts more than 8 weeks.
Also known as: Dyspnoea | difficulty breathing | respiration difficult | short of breath | winded
Includes: Orthopnoea
Excludes: Transient tachypnoea of newborn
[NB32.3Z] Injury of lung, unspecified
Also known as: Injury of lung, unspecified | Certain injuries of lung | injury of lung NOS | acute lung injury NOS | lung wound NOS
[NB91.1Z] Injury of liver, unspecified
Also known as: Injury of liver, unspecified | Injury of liver | liver wound NOS | liver fracture NOS | hepatocellular injury
[ND56.1] Open wound of unspecified body region
Also known as: Open wound of unspecified body region | cut NOS | open wound NOS | penetrating wound NOS | Puncture wound with foreign body unspecified body region
Excludes: Traumatic amputations involving multiple body regions | Open wounds involving multiple body regions | traumatic amputation NOS
[MD81.3] Acute abdomen
Definition: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases
Also known as: Acute abdomen | acute abdominal pain syndrome | surgical abdomen | abdominal acute syndrome | severe abdomen pain
[JA01.0] Abdominal pregnancy
Definition: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy.
Also known as: Abdominal pregnancy | abdomen pregnancy | intraperitoneal pregnancy
Excludes: Maternal care for viable fetus in abdominal pregnancy | Delivery of viable fetus in abdominal pregnancy
[ME04.Z] Ascites, unspecified
Also known as: Ascites, unspecified | Ascites | abdominal dropsy | hydrops abdominis | ascites NOS
[NB9Y] Other specified injuries to the abdomen, lower back, lumbar spine or pelvis
Also known as: Other specified injuries to the abdomen, lower back, lumbar spine or pelvis | Abdominal wall trauma | Injury of pelvic floor | pelvic floor blunt injury | pelvic floor blunt trauma
=== GRAPH WALKS ===
--- Walk 1 ---
[MD11.5] Dyspnoea
Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...
--EXCLUDES--> [?] Transient tachypnoea of newborn
Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....
--PARENT--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 2 ---
[MD11.5] Dyspnoea
Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...
--EXCLUDES--> [?] Transient tachypnoea of newborn
Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....
--PARENT--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 3 ---
[NB32.3Z] Injury of lung, unspecified
--PARENT--> [NB32.3] Certain injuries of lung
--CHILD--> [NB32.32] Inhalation injury of lung
--- Walk 4 ---
[NB32.3Z] Injury of lung, unspecified
--PARENT--> [NB32.3] Certain injuries of lung
--CHILD--> [NB32.32] Inhalation injury of lung
--- Walk 5 ---
[NB91.1Z] Injury of liver, unspecified
--PARENT--> [NB91.1] Injury of liver
Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....
--CHILD--> [NB91.11] Laceration of liver, minor
--- Walk 6 ---
[NB91.1Z] Injury of liver, unspecified
--PARENT--> [NB91.1] Injury of liver
Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....
--RELATED_TO--> [?] Birth injury to liver
Def: Rupture or subcapsular haemorrhage into the liver parenchyma as a result of birth trauma usually seen in large for gestational age infants, those with hepatomegaly, those born by breech delivery; may ...
|
[
"[MD11.5] Dyspnoea\n Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...\n --EXCLUDES--> [?] Transient tachypnoea of newborn\n Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....\n --PARENT--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[MD11.5] Dyspnoea\n Def: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a pres...\n --EXCLUDES--> [?] Transient tachypnoea of newborn\n Def: Transient tachypnoea of newborn is usually a benign self-limiting illness of term and near-term infants demonstrating increased respiratory rate and requiring supplementary oxygen after birth....\n --PARENT--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[NB32.3Z] Injury of lung, unspecified\n --PARENT--> [NB32.3] Certain injuries of lung\n --CHILD--> [NB32.32] Inhalation injury of lung",
"[NB32.3Z] Injury of lung, unspecified\n --PARENT--> [NB32.3] Certain injuries of lung\n --CHILD--> [NB32.32] Inhalation injury of lung",
"[NB91.1Z] Injury of liver, unspecified\n --PARENT--> [NB91.1] Injury of liver\n Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....\n --CHILD--> [NB91.11] Laceration of liver, minor",
"[NB91.1Z] Injury of liver, unspecified\n --PARENT--> [NB91.1] Injury of liver\n Def: Damage inflicted on the liver as the direct or indirect result of an external force, with or without disruption of structural continuity....\n --RELATED_TO--> [?] Birth injury to liver\n Def: Rupture or subcapsular haemorrhage into the liver parenchyma as a result of birth trauma usually seen in large for gestational age infants, those with hepatomegaly, those born by breech delivery; may ..."
] |
MD11.5
|
Dyspnoea
|
[
{
"from_icd11": "MD11.5",
"icd10_code": "R0603",
"icd10_title": "Acute respiratory distress"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0601",
"icd10_title": "Orthopnea"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0602",
"icd10_title": "Shortness of breath"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0600",
"icd10_title": "Dyspnea, unspecified"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R0609",
"icd10_title": "Other forms of dyspnea"
},
{
"from_icd11": "MD11.5",
"icd10_code": "R060",
"icd10_title": "Dyspnea"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27321A",
"icd10_title": "Contusion of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27322A",
"icd10_title": "Contusion of lung, bilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27331S",
"icd10_title": "Laceration of lung, unilateral, sequela"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27331A",
"icd10_title": "Laceration of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27329A",
"icd10_title": "Contusion of lung, unspecified, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27339A",
"icd10_title": "Laceration of lung, unspecified, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27391A",
"icd10_title": "Other injuries of lung, unilateral, initial encounter"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27391S",
"icd10_title": "Other injuries of lung, unilateral, sequela"
},
{
"from_icd11": "NB32.3Z",
"icd10_code": "S27321D",
"icd10_title": "Contusion of lung, unilateral, subsequent encounter"
}
] |
R0603
|
Acute respiratory distress
|
A 55-year-old woman presented with a painful and large palpable mass at the right upper quadrant of the abdomen. She reported that she had had this for 2 months prior to admission. This patient had no previous history of similar problems or any prior medical or surgical conditions. On physical examination, a right upper quadrant mass with tenderness was palpable. The laboratory examination revealed that the results of liver and renal function tests, urinary analysis, and complete blood count tests were within the normal ranges. Tumor marker levels, carcinoembryonic antigen (CEA:11.8 ng/ml) and carbohydrate antigen 19-9 , were elevated. Contrast-enhanced computed tomography (CT) showed a tumor in the fundus and body of the gallbladder, 6 × 4 cm in size, with a peripheral wall enhancement . This tumor extended to the liver and transverse colon . An enlarged lymph node with a diameter of 23 mm was detected in the area of the cystic duct . The RHA from the proper hepatic artery runs close to this lymph node , suggesting extracapsular invasion into the RHA. The estimated volume ratio of the left hepatic lobe to the whole liver was 0.3. Endoscopic retrograde cholangiography showed a stricture of the common hepatic duct and deficit of the cystic duct . Fluorodeoxyglucose positron emission tomography showed high fluorodeoxyglucose uptake (accumulation) in the gallbladder tumor and cystic duct lymph node , while there was no evidence of distant metastasis. Taken together with these examinations, this patient was diagnosed with locally advanced gallbladder cancer extending to the liver parenchyma and the transverse colon with lymph node metastasis in the area of the cystic duct, invading the RHA and common hepatic duct. We planned surgical intervention for curative intent since there was no evidence of distant metastasis.At laparotomy, neither peritoneal dissemination nor distant metastasis was detected. The transverse colon invaded by the tumor was partially resected. The lower common bile duct was dissected after its ligation as low as possible in the pancreas. The enlarged lymph node was involved in the RHA and tightly adhered to the common hepatic duct. This finding strongly indicated extracapsular invasion of the lymph node, extending to the RHA and the common hepatic duct. Intraoperative Doppler ultrasonography showed sufficient right intrahepatic arterial flow despite the clamp of the RHA. We speculated that the right intrahepatic arterial flow would be preserved by the interlobar hepatic artery at the hepatic hilum, perfused from the left hepatic artery. The patient underwent extended cholecystectomy with a 2-cm wedge resection of the liver parenchyma as a safety margin combined with regional lymph node dissection. The RHA was dissected at both the distal and proximal side, as much as possible, and divided without reconstruction. The right and left hepatic ducts were carefully dissected and divided with a preservation of the communication across the hilar plate to avoid injury of the interlobar hepatic artery . After this procedure, a specimen of the tumor substance was removed. The right intrahepatic arterial flow was detected by Doppler ultrasonography. Separate orifices of the right and left hepatic ducts were joined to form a single orifice and biliary reconstruction was performed using a Roux-en-Y hepaticojejunostomy. The duration of operation was 485 minutes and the amount of blood loss was 380 g without blood transfusion.Pathological examination revealed moderately differentiated adenocarcinoma situated mainly in the body and fundus of gallbladder, invading the transverse colon, liver parenchyma, and lymph node in the area of the cystic duct . The neck of the gallbladder was intact. There was no evidence of lymph node involvement in the hepatoduodenal ligament, behind the pancreatic head or in the common hepatic artery region. Extracapsular invasion of the lymph node extended to the common hepatic duct and periadventitial tissue of the RHA, while there was no evidence of invasion of the adventitia of the RHA . R0 resection was achieved. According to the International Union Against Cancer (UICC) classification system, pathological staging was pT3N1(1/16)M0, Stage IIB.At postoperative day 1, the bilirubin concentration in the drain fluid was 17.3 mg/dl, indicating leakage of the bilioenteric anastomosis. Contrast-enhanced CT was performed on the same day and revealed that there was no evidence of intra-abdominal fluid collection. Intrahepatic arterial flow was preserved in the right liver lobe, although parenchymal enhancement was delayed . Postoperative changes in serum biochemistry included a rapid increase of transaminase (aspartate transaminase, 830 U/l; alanine transaminase 495 U/l), lactate dehydrogenase (949 u/l), and total bilirubin (3.1 mg/dl) on postoperative day 1, while they decreased gradually after postoperative day 2. The leakage of the bilioenteric anastomosis was treated conservatively with continuous drainage, since the patient’s general condition was stable. This patient was discharged at postoperative day 45 and the drainage tube was removed at postoperative day 60.
| 4.039063
| 0.974609
|
sec[1]/p[0]
|
en
| 0.999996
|
24912578
|
https://doi.org/10.1186/1477-7819-12-183
|
[
"hepatic",
"duct",
"lymph",
"node",
"this",
"liver",
"common",
"tumor",
"postoperative",
"gallbladder"
] |
[
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
},
{
"code": "DC10.02",
"title": "Obstruction of bile duct"
},
{
"code": "DC10.00",
"title": "Obstruction of cystic duct"
},
{
"code": "DC13",
"title": "Cholangitis"
},
{
"code": "LB20.23",
"title": "Structural developmental anomalies of cystic duct"
},
{
"code": "DC10.2",
"title": "Fistula of gallbladder or bile duct"
}
] |
=== ICD-11 CODES FOUND ===
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
[DC10.02] Obstruction of bile duct
Also known as: Obstruction of bile duct | extrahepatic biliary obstruction | extrahepatic bile duct obstruction | bile duct obstruction | bile stasis
Excludes: with cholelithiasis
[DC10.00] Obstruction of cystic duct
Also known as: Obstruction of cystic duct | cystic duct obstruction | cystic ductal obstruction | obstructed cystic duct | Acquired cystic duct atresia
[DC13] Cholangitis
Also known as: Cholangitis | acute cholangiolitis | ascending cholangitis | cholangiolitis | cholangitis NOS
Excludes: chronic nonsuppurative destructive cholangitis | cholangitis with cholelithiasis | Primary sclerosing cholangitis
[LB20.23] Structural developmental anomalies of cystic duct
Also known as: Structural developmental anomalies of cystic duct | congenital deformity of cystic duct | cystic duct anomaly | cystic duct deformity | cystic duct distortion
[DC10.2] Fistula of gallbladder or bile duct
Definition: This is an abnormal connection or passageway between gallbladder or bile duct and other organs.
Also known as: Fistula of gallbladder or bile duct | fistula of gallbladder | gallbladder fistula | Cholecystocolic fistula | Cholecystoduodenal fistula
=== GRAPH WALKS ===
--- Walk 1 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--EXCLUDES--> [?] Unspecified jaundice
Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....
--- Walk 2 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--EXCLUDES--> [?] Unspecified jaundice
Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....
--- Walk 3 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--CHILD--> [DB97.2] Chronic hepatitis, not elsewhere classified
--- Walk 4 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--PARENT--> [?] Diseases of liver
--- Walk 5 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--EXCLUDES--> [?] Fibropolycystic liver disease
--- Walk 6 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium
Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium....
|
[
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --EXCLUDES--> [?] Unspecified jaundice\n Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....",
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --EXCLUDES--> [?] Unspecified jaundice\n Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --CHILD--> [DB97.2] Chronic hepatitis, not elsewhere classified",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --PARENT--> [?] Diseases of liver",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --EXCLUDES--> [?] Fibropolycystic liver disease",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium\n Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium...."
] |
DB9Z
|
Diseases of liver, unspecified
|
[
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K762",
"icd10_title": "Central hemorrhagic necrosis of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K70-K77",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K778",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K72",
"icd10_title": "Hepatic failure, not elsewhere classified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K76",
"icd10_title": "Other diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
}
] |
K7681
|
Hepatopulmonary syndrome
|
A 51-year-old male patient was admitted to the university hospital with chest discomfort, dyspnoea, and decreased exertion capacity. A physical examination on admission revealed an enlarged heart, a harsh systolic ejection murmur, and a decrescendo diastolic murmur in the aortic area. The electrocardiogram showed sinus rhythm with signs of left ventricular hypertrophy. The chest X-ray showed enlarged left heart chambers. Transthoracic echocardiography (TTE) revealed an ejection fraction (EF) of 43% (normal: >60%). No resting wall motion abnormality was detected, mixed aortic valve disease was confirmed, the stenosis gradient was 74/47 mmHg, the aortic valve area was 0.33 cm 2 , aortic insufficiency grade was found to be II–III, and the pressure half time value was 222 ms. Grade II tricuspid insufficiency with a pulmonary pressure of 70 mmHg was confirmed. The cardiac risk factors were hypertension, Type 2 diabetes mellitus, hyperlipidaemia, peripheral artery disease, and smoking. The right femoral common and right femoral superficial artery had been intervened prior to surgery. The left common iliac artery and left superficial femoral artery showed non-significant lesions at that time. Both common carotid arteries showed non-significant lesions. Coronary angiography revealed a non-significant proximal circumflex artery lesion. The Society of Thoracic Surgeons risk score (STS score) and EuroSCORE II before primary AVR were 0.842 and 2.8%, respectively. Aortic valve replacement was performed according to guidelines, and a LivaNova Bicarbon Slimline A-25 mm mechanical valve was implanted. Four days later, a reoperation had to be performed due to haematoma causing right heart compression, which was evacuated. Active bleeding was not revealed. Two weeks later, another reoperation had to be performed due to repeat haematoma formation in the pericardium. Discharge TTE showed good mechanical valve function with a peak gradient of 19 mmHg, and there was no sign of any PVL. Six months after discharge, the patient started to experience dyspnoea on exertion and also at rest. Upon readmission, haemolytic anaemia was discovered (Hgb: 92–82 g/dL, normal value: >130 g/dL, serum bilirubin level: 23.3 µmol/L, normal value <21 µmol/L). The patient was in a state of decompensation, partially reflected by brain natriuretic peptide level, which was 7244 pg/mL. Transoesophageal echocardiography and 3D TOE revealed severe PVL (the width of the regurgitation jet was 30–50% of the left ventricle width) located supposedly at the left coronary sinus . Computed tomography angiography helped to pinpoint the largest ostium of the PVL located at the left coronary sinus and quantify the regurgitation jet . Computed tomography angiography discovered a chronic occlusion of the right subclavian artery, and distal filling was provided by collaterals from the right vertebral artery. The left subclavian artery was free of disease. Pleural effusion was present in both pleural cavities, which also supported the diagnosis of cardiac decompensation. Shortly after readmission, the patient became noradrenaline dependent. The calculated STS score for mortality was 5.85%, which was in line with EuroSCORE II (42.35%). Both preoperative scores represent an extremely high surgical risk for mortality. Percutaneous PVL closure represented the consensus of the heart team. Due to peripheral vascular disease in both lower extremities and right subclavian artery occlusion, a decision was made to use the left DRA as the initial approach to reduce the potential risk of vascular access site complications and bleeding risk. The left DRA was punctured with ultrasound guidance , and a 6 French (F) Terumo radial sheath (Terumo, Japan) was introduced and later replaced with a Sheathless 8.5F MP1 catheter . Aortography confirmed a large-volume PVL . With fluoroscopy and TOE and 3D TOE guidance, a Gladius 0.018″ guidewire (Asahi, USA) could pass through the largest opening of the leak into the left ventricle. It was followed by a CXI 4.0 support catheter (Cook, USA). After exchanging it with Confida 0.035′ wire (Medtronic, USA), through the Sheathless guide catheter, a 14/5 mm Amplatzer Vascular plug III (AVPIII; Abbott, USA) was deployed after careful positioning to avoid mechanical valve leaflet interaction aided by TOE, 3D TOE, and fluoroscopy . Control angiography and TOE still revealed a large-volume residual leak . With a Halberd 0.018″ wire (Asahi, Japan), it was possible to cross the left ventricle beside the prior-implanted AVPIII through the remaining leak in the ostium. A 10/5 mm AVPIII was deployed in the largest remaining leak without compromising mechanical valve function . Final angiography revealed only a small volume of contrast entering the left ventricle through the leak . Transoesophageal echocardiography confirmed the angiography result . By the end of the procedure, no medical haemodynamic support had to be provided . The patient was discharged home five days later. Discharge TTE confirmed good mechanical aortic valve function, increased left ventricle EF, minimal regurgitation, and proper position of the deployed vascular plugs .
| 4.019531
| 0.976074
|
sec[2]/p[0]
|
en
| 0.999997
|
39108997
|
https://doi.org/10.1093/ehjcr/ytae366
|
[
"artery",
"valve",
"aortic",
"angiography",
"risk",
"mechanical",
"ventricle",
"leak",
"heart",
"both"
] |
[
{
"code": "BD5Z",
"title": "Diseases of arteries or arterioles, unspecified"
},
{
"code": "BD52",
"title": "Certain specified disorders of arteries or arterioles"
},
{
"code": "BD52.3",
"title": "Rupture of artery"
},
{
"code": "BD52.2",
"title": "Stricture of artery"
},
{
"code": "BD40.Z",
"title": "Atherosclerotic chronic arterial occlusive disease, unspecified"
},
{
"code": "GB61.Z",
"title": "Chronic kidney disease, stage unspecified"
},
{
"code": "BC00",
"title": "Multiple valve disease"
},
{
"code": "BB9Z",
"title": "Pulmonary valve disease, unspecified"
},
{
"code": "BB6Z",
"title": "Mitral valve disease, unspecified"
},
{
"code": "LA8Z",
"title": "Structural developmental anomaly of heart or great vessels, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[BD5Z] Diseases of arteries or arterioles, unspecified
Also known as: Diseases of arteries or arterioles, unspecified | artery disease NOS | arterial disease NOS | arteriolar disease NOS | disorder of artery NOS
[BD52] Certain specified disorders of arteries or arterioles
Also known as: Certain specified disorders of arteries or arterioles | Aortic dilatation - joint hypermobility - arterial tortuosity | Generalised arterial calcification of infancy | Median arcuate ligament syndrome | Aortic root abscess
Excludes: collagen (vascular) diseases | Hypersensitivity angiitis | Acute arterial occlusion
[BD52.3] Rupture of artery
Also known as: Rupture of artery | ruptured artery | artery fistula | Aortic duodenal fistula | Aortic colon fistula
Excludes: traumatic rupture of artery - see injury of blood vessel by body region
[BD52.2] Stricture of artery
Also known as: Stricture of artery | arterial stenosis | arterial stricture | artery stricture | stenosis of artery
[BD40.Z] Atherosclerotic chronic arterial occlusive disease, unspecified
Also known as: Atherosclerotic chronic arterial occlusive disease, unspecified | Atherosclerotic chronic arterial occlusive disease | arteriosclerosis, NOS | generalised atherosclerosis | atherosclerosis NOS
[GB61.Z] Chronic kidney disease, stage unspecified
Also known as: Chronic kidney disease, stage unspecified | Chronic kidney disease | chronic renal failure | chronic kidney failure | chronic renal disease
[BC00] Multiple valve disease
Also known as: Multiple valve disease | Multiple valve disease of unspecified origin | multiple valvular cardiac dysfunction | multivalvular cardiac dysfunction | Disorders of both mitral and aortic valves
[BB9Z] Pulmonary valve disease, unspecified
Also known as: Pulmonary valve disease, unspecified | rheumatic heart disease of pulmonary valve, unspecified | chronic rheumatic pulmonary valve endocarditis | chronic rheumatic pulmonary valvular endocarditis | rheumatic disease of pulmonary valve
[BB6Z] Mitral valve disease, unspecified
Also known as: Mitral valve disease, unspecified | noninfective endocarditis of mitral valve | rheumatic heart disease of mitral valve, unspecified | mitral valvulopathy | mitral valve cardiopathy
[LA8Z] Structural developmental anomaly of heart or great vessels, unspecified
Also known as: Structural developmental anomaly of heart or great vessels, unspecified | Heart malformations | Cardiac malformations | congenital anomaly of heart | congenital heart disease
=== GRAPH WALKS ===
--- Walk 1 ---
[BD5Z] Diseases of arteries or arterioles, unspecified
--PARENT--> [?] Diseases of arteries or arterioles
--CHILD--> [BD50] Aortic aneurysm or dissection
Def: Aortic aneurysm is a term for any swelling (dilation or aneurysm) of the aorta to greater than 1.5 times normal, usually representing an underlying weakness in the wall of the aorta at that location. ...
--- Walk 2 ---
[BD5Z] Diseases of arteries or arterioles, unspecified
--PARENT--> [?] Diseases of arteries or arterioles
--EXCLUDES--> [?] Diseases of coronary artery
Def: Conditions affecting the blood perfusion of the heart....
--- Walk 3 ---
[BD52] Certain specified disorders of arteries or arterioles
--EXCLUDES--> [?] Acute arterial occlusion
--CHILD--> [?] Acute aortoiliac occlusion
--- Walk 4 ---
[BD52] Certain specified disorders of arteries or arterioles
--EXCLUDES--> [?] Nonorgan specific systemic autoimmune disorders
--CHILD--> [?] Lupus erythematosus
Def: An autoimmune non-organ specific inflammatory disease characterised by the presence of antibodies to DNA, RNA and other components of the nucleus. It has a very variable clinical presentation and cour...
--- Walk 5 ---
[BD52.3] Rupture of artery
--EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes
Def: !markdown
In the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...
--EXCLUDES--> [?] Pathological fracture
--- Walk 6 ---
[BD52.3] Rupture of artery
--EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes
Def: !markdown
In the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...
--CHILD--> [?] Injuries to the neck
|
[
"[BD5Z] Diseases of arteries or arterioles, unspecified\n --PARENT--> [?] Diseases of arteries or arterioles\n --CHILD--> [BD50] Aortic aneurysm or dissection\n Def: Aortic aneurysm is a term for any swelling (dilation or aneurysm) of the aorta to greater than 1.5 times normal, usually representing an underlying weakness in the wall of the aorta at that location. ...",
"[BD5Z] Diseases of arteries or arterioles, unspecified\n --PARENT--> [?] Diseases of arteries or arterioles\n --EXCLUDES--> [?] Diseases of coronary artery\n Def: Conditions affecting the blood perfusion of the heart....",
"[BD52] Certain specified disorders of arteries or arterioles\n --EXCLUDES--> [?] Acute arterial occlusion\n --CHILD--> [?] Acute aortoiliac occlusion",
"[BD52] Certain specified disorders of arteries or arterioles\n --EXCLUDES--> [?] Nonorgan specific systemic autoimmune disorders\n --CHILD--> [?] Lupus erythematosus\n Def: An autoimmune non-organ specific inflammatory disease characterised by the presence of antibodies to DNA, RNA and other components of the nucleus. It has a very variable clinical presentation and cour...",
"[BD52.3] Rupture of artery\n --EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes\n Def: !markdown\nIn the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...\n --EXCLUDES--> [?] Pathological fracture",
"[BD52.3] Rupture of artery\n --EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes\n Def: !markdown\nIn the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...\n --CHILD--> [?] Injuries to the neck"
] |
BD5Z
|
Diseases of arteries or arterioles, unspecified
|
[
{
"from_icd11": "BD5Z",
"icd10_code": "I7389",
"icd10_title": "Other specified peripheral vascular diseases"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I7419",
"icd10_title": "Embolism and thrombosis of other parts of aorta"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I7411",
"icd10_title": "Embolism and thrombosis of thoracic aorta"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I7410",
"icd10_title": "Embolism and thrombosis of unspecified parts of aorta"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I7381",
"icd10_title": "Erythromelalgia"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I745",
"icd10_title": "Embolism and thrombosis of iliac artery"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I789",
"icd10_title": "Disease of capillaries, unspecified"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I748",
"icd10_title": "Embolism and thrombosis of other arteries"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I749",
"icd10_title": "Embolism and thrombosis of unspecified artery"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I781",
"icd10_title": "Nevus, non-neoplastic"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I788",
"icd10_title": "Other diseases of capillaries"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I744",
"icd10_title": "Embolism and thrombosis of arteries of extremities, unspecified"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I70-I79",
"icd10_title": ""
},
{
"from_icd11": "BD5Z",
"icd10_code": "I74",
"icd10_title": "Arterial embolism and thrombosis"
},
{
"from_icd11": "BD5Z",
"icd10_code": "I73",
"icd10_title": "Other peripheral vascular diseases"
}
] |
I7389
|
Other specified peripheral vascular diseases
|
A 58-year-old Japanese woman presented with chest discomfort and low-grade fever that had persisted for 2 months. She was a dental technician but did not regularly wear a dust mask in the workplace. She previously had a smoking history of 2 pack/year and no medical history. On admission, her body temperature was 37 °C. Physical examination results were almost normal. The laboratory examinations were also normal including blood smear differentials, C-reactive protein, serological tests for autoimmune disorders and malignant and hematological disorders, and serological tests for infectious diseases (Table 1 ). Chest X ray and computed tomography revealed multiple well-defined nodules in both lungs and fluorodeoxyglucose (FDG)-positron emission tomography revealed abnormal FDG uptake in the same lesions with a maximal standardized uptake value (SUV [max]) of 5.6 . Then, we performed thoracoscopic partial resection of the lesions in the right upper and middle lobes . Histological examination of the specimens revealed foreign body-type giant cells and mild and focal chronic inflammatory changes with the infiltration of lymphocytes and plasma cells together with eosin-positive deposits . The deposits were direct fast scarlet (DFS) staining positive and produced an apple-green birefringence under crossed polarized light . Congo-red staining was also positive . Based on these results, we concluded that the substance in the lesion was compatible with amyloid. Although we diagnosed the patient with pulmonary amyloidosis, there was no obvious underlying causes that could typically cause pulmonary amyloidosis, including rheumatoid arthritis, primary Sjögren’s syndrome or multiple myeloma. We also excluded plasma cell neoplasm and multicentric Castleman’s disease because there was no infiltration of atypical plasma cells nor formation of multicentric lymphoid follicles in the lesions. Consequently, we focused on her occupational history and performed electron probe X-ray microanalysis (EPMA) of the specimens to evaluate the cause of pulmonary amyloidosis. EPMA of the specimens revealed the deposition of silica throughout the granulomatous lesions as well as among giant cells . From these results, we finally diagnosed the patient with multiple lung granulomas with amyloid deposition caused by chronic silica exposure. Afterward, her symptoms improved and the disease has not progressed for 2 years since proper measures against additional occupational exposure were implemented. Table 1 Results of laboratory examinations on admission Blood count WBC 5800/μl Neut 56.7% Eos 3.6% Bas 1.0% Mo 4.9% Ly 33.8% RBC 430 × 10 4 /μl Hb 13.0 g/dl Plt 28.4 × 10 4 /μl Arterial blood gas (room air) pH 7.427 PaO 2 94.5 Torr PaCO 2 36.8 Torr HCO 3 - 23.7 mEq/l BE −0.3 mEq/l Blood chemistry TP 8.2 g/dl Alb 5.0 g/dl T-bil 0.3 mg/dl AST 16 IU/l ALT 16 IU/l LDH 178 IU/l ALP 242 IU/l γGTP 16 IU/l BUN 17.8 mg/dl Cre 0.6 mg/dl Na 143 mEq/l K 4.0 mEq/l Cl 108 mEq/l Ca 9.9 mg/dl Serum CRP 0.02 mg/dl IgG 1952 mg/dl IgA 309 mg/dl IgM 95 mg/dl IgG4 25 mg/dl CEA 1.96 ng/ml CA19-9 2.0 U/ml ANA x 40 Anti CCP antibody < 0.6 U/ml anti SS-Aantibody negative Anti SS-B antibody negative Serum amyloid A 2.9 μg/ml s-IL-2R 412 IU/ml β-D glucan < 5.0 pg/ml Cryptococcus antigen negative Aspergillus antigen negative Candida antigen negative T-SPOT negative Serum protein electrophoresis M protein negative Urine protein electrophoresis Bence-Jones protein negative Neut neutrophil, UA uric acid, CRP C-reactive protein, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, CCP cyclic citrullinated peptide, s-IL-2R soluble interluekin 2 receptor Fig. 1 a, b Chest X ray ( a ) and chest computed tomography on admission ( b ) revealed multiple well-defined nodules in both lungs. c Fluorodeoxyglucose (FDG)-positron emission tomography revealed abnormal FDG uptake in the same lesions with a maximal standardized uptake value (SUV [max]) of 5.6 Fig. 2 Histopathological findings of the lung nodules. a Macroscopic examination of a white hard nodule in the right middle lobe. b Low-magnification image of a hematoxylin and eosin (HE) stained specimen revealed granuloma formation with foreign body-type giant cells (arrow) and mild and focal chronic inflammatory changes with eosin-positive deposits (asterisk). c and d The images of direct fast scarlet (DFS) staining revealed that the deposits were DFS positive (asterisk) ( c , at lower-magnification, and d , at higher-magnification). e The DFS staining-positive lesions produced an apple-green birefringence under crossed polarized light (arrows) (× 100). The collagen fibrils appeared white (arrow heads). f The deposits were Congo red positive (asterisk). Foreign body-type giant cells were detected (arrows) (× 100). g and h A representative photograph of HE stained specimen ( g ) and its image of electron probe X-ray microanalysis (EPMA) ( h ). A two-dimension EPMA-wavelength dispersive spectrometer (WDS) image of an elemental map corresponding to the area shown in ( h ), showing orange dots indicating silica (Si) accumulated in giant cells (arrows). The distribution of amino nitrogen was colored green ( h )
| 4.136719
| 0.956055
|
sec[1]/p[0]
|
en
| 0.999999
|
29788999
|
https://doi.org/10.1186/s12890-018-0654-0
|
[
"cells",
"protein",
"lesions",
"giant",
"deposits",
"antigen",
"chest",
"that",
"body",
"blood"
] |
[
{
"code": "MF9Y",
"title": "Other specified clinical findings on examination of urine, without diagnosis"
},
{
"code": "5C56.20",
"title": "Mucolipidosis"
},
{
"code": "3A51.1",
"title": "Sickle cell disease without crisis"
},
{
"code": "9A96.3",
"title": "Primary anterior uveitis"
},
{
"code": "3A61.Z",
"title": "Acquired pure red cell aplasia, unspecified"
},
{
"code": "5B71",
"title": "Protein deficiency"
},
{
"code": "5B7Z",
"title": "Unspecified undernutrition"
},
{
"code": "DA96.02",
"title": "Malabsorption or intolerance of specific nutrients"
},
{
"code": "MF96.Z",
"title": "Proteinuria, unspecified"
},
{
"code": "3B61.1",
"title": "Acquired thrombophilia"
}
] |
=== ICD-11 CODES FOUND ===
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
Also known as: Other specified clinical findings on examination of urine, without diagnosis | Methaemoglobinuria | Other and unspecified abnormal findings in urine | Calciuria | Cells and casts in urine
[5C56.20] Mucolipidosis
Also known as: Mucolipidosis | Mucolipidosis type 3 | Pseudo-Hurler polydystrophy | Pseudo-Hurler disease | Mucolipidosis type 2
Excludes: Sialidosis (mucolipidosis type 1)
[3A51.1] Sickle cell disease without crisis
Definition: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may present with fatigue, shortness of breath, dizziness, headaches, pallor of skin or mucous membranes, and jaundice. This disorder is confirmed by identification of HbS mutation by genetic testing.
Also known as: Sickle cell disease without crisis | Hb-SS disease without crisis | HbSS without crisis | Sickle-cell anaemia without crisis | SCD - [sickle cell disease]
[9A96.3] Primary anterior uveitis
Definition: This refers to primary inflammation of the uvea. The uvea consists of the middle, pigmented, vascular structures of the eye and includes the iris, ciliary body, and choroid.
Also known as: Primary anterior uveitis | anterior chamber cell
[3A61.Z] Acquired pure red cell aplasia, unspecified
Also known as: Acquired pure red cell aplasia, unspecified | Acquired pure red cell aplasia | acquired red cell aplasia | red cell aplasia NOS | pure red cell aplastic anaemia
[5B71] Protein deficiency
Also known as: Protein deficiency | protein deprivation
[5B7Z] Unspecified undernutrition
Also known as: Unspecified undernutrition | Malnutrition NOS | nutritional deficiency NOS | nutritional depletion NOS | severe malnutrition NOS
[DA96.02] Malabsorption or intolerance of specific nutrients
Definition: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken for food allergy, which is primarily involving the immune reaction against the food.
Also known as: Malabsorption or intolerance of specific nutrients | Carbohydrate intolerance other than lactose | disorder of carbohydrate absorption | Malabsorption due to intolerance to carbohydrate | carbohydrate intolerance
[MF96.Z] Proteinuria, unspecified
Also known as: Proteinuria, unspecified | Proteinuria | Albuminuria NOS | Proteinuria NOS
[3B61.1] Acquired thrombophilia
Definition: A disease caused by determinants arising after birth. This disease is characterised by abnormality of blood coagulation that increases the risk of thrombosis, clots in blood vessels. This disease may present with deep vein thrombosis or pulmonary embolism. Confirmation is identification of abnormal blood coagulation in a blood sample.
Also known as: Acquired thrombophilia | Gaisbock syndrome | polycythaemia due to stress | stress erythrocytosis | stress polycythaemia
=== GRAPH WALKS ===
--- Walk 1 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--EXCLUDES--> [?] Inborn errors of carbohydrate metabolism
--- Walk 2 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--EXCLUDES--> [?] Inborn errors of carbohydrate metabolism
--- Walk 3 ---
[5C56.20] Mucolipidosis
--PARENT--> [5C56.2] Glycoproteinosis
Def: These are lysosomal storage diseases affecting glycoproteins, resulting from defects in lysosomal function. The term is sometimes reserved for conditions involving degradation of glycoproteins....
--CHILD--> [5C56.2Y] Other specified glycoproteinosis
--- Walk 4 ---
[5C56.20] Mucolipidosis
--EXCLUDES--> [?] Sialidosis
--PARENT--> [?] Oligosaccharidosis
--- Walk 5 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--CHILD--> [3A51.0] Sickle cell trait
Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ...
--- Walk 6 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--CHILD--> [3A51.0] Sickle cell trait
Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ...
|
[
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --EXCLUDES--> [?] Inborn errors of carbohydrate metabolism",
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --EXCLUDES--> [?] Inborn errors of carbohydrate metabolism",
"[5C56.20] Mucolipidosis\n --PARENT--> [5C56.2] Glycoproteinosis\n Def: These are lysosomal storage diseases affecting glycoproteins, resulting from defects in lysosomal function. The term is sometimes reserved for conditions involving degradation of glycoproteins....\n --CHILD--> [5C56.2Y] Other specified glycoproteinosis",
"[5C56.20] Mucolipidosis\n --EXCLUDES--> [?] Sialidosis\n --PARENT--> [?] Oligosaccharidosis",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --CHILD--> [3A51.0] Sickle cell trait\n Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ...",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --CHILD--> [3A51.0] Sickle cell trait\n Def: A disease caused by genetic inheritance of one abnormal allele of the haemoglobin gene. This disease does not display the severe symptoms of sickle cell disease that occurs in homozygous individuals. ..."
] |
MF9Y
|
Other specified clinical findings on examination of urine, without diagnosis
|
[
{
"from_icd11": "3A51.1",
"icd10_code": "D571",
"icd10_title": "Sickle-cell disease without crisis"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D609",
"icd10_title": "Acquired pure red cell aplasia, unspecified"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D608",
"icd10_title": "Other acquired pure red cell aplasias"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D60",
"icd10_title": "Acquired pure red cell aplasia [erythroblastopenia]"
},
{
"from_icd11": "5B71",
"icd10_code": "E46",
"icd10_title": "Unspecified protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E440",
"icd10_title": "Moderate protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E441",
"icd10_title": "Mild protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E640",
"icd10_title": "Sequelae of protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E44",
"icd10_title": "Protein-calorie malnutrition of moderate and mild degree"
},
{
"from_icd11": "5B71",
"icd10_code": "E45",
"icd10_title": "Retarded development following protein-calorie malnutrition"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E43",
"icd10_title": "Unspecified severe protein-calorie malnutrition"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E538",
"icd10_title": "Deficiency of other specified B group vitamins"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E569",
"icd10_title": "Vitamin deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E638",
"icd10_title": "Other specified nutritional deficiencies"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E639",
"icd10_title": "Nutritional deficiency, unspecified"
}
] |
D571
|
Sickle-cell disease without crisis
|
The patient was a 45-year-old man with a chief complaint of discomfort in the maxillary right central and lateral incisors for one year. Mucosal swelling and spontaneous pain were seen at the labial gingiva of the maxillary right lateral incisor, and tooth mobility started at three months before the initial examination ( Figure 1(a) ). Oral examination revealed the mobility of the maxillary right lateral incisor as grade 2 and that of the central incisor as grade 1. In addition, the patient had both spontaneous and occlusal pain. Intraoral periapical radiographs showed radiolucency at the apical regions of the central and lateral incisors, although no dental caries were detected in these incisors ( Figure 1(b) ). Both teeth had periodontal pockets around 1–2 mm circumferentially in depth, and there was no bleeding on probing sites. Furthermore, the cold thermal examination revealed normal responses of the vital dental pulp at both incisors. Panoramic radiography showed numerous dental caries and apical lesions in the oral cavity ( Figure 1(c) ). The closest lesion to the site of the chief complaint was detected at the maxillary right first premolar, which was previously treated by root canal treatment. A connecting bridge was attached, linking from the first premolar to the first molar, and there was no occlusal pain on percussion. The adjacent maxillary right canine was intact without caries or periodontal disease. Intraoral periapical radiography revealed an apical lesion in the maxillary right first premolar ( Figure 1(d) ). However, the apical lesion appeared small on intraoral periapical radiographs, there was no swelling of the mucosa around the root, and the patient had no symptoms. CBCT was performed using Trophypan Smart Osiris 3D (Carestream Dental, Atlanta, GA) to obtain three-dimensional information. The CBCT images revealed marked apical radiolucency and bone resorption around the lateral incisor. We also found apical radiolucency with destruction of the cortical bone on the buccal side, measuring ≥12 mm in diameter on the lateral incisor, and an apical radiolucency measuring ≥8 mm in diameter on the central incisor (Figures 2(a) – 2(c) ). Root canal filling material was found on the buccal root of the maxillary right first premolar, and no root canal filling agents were seen in the palatal root, with an apical lesion measuring more than 10 mm in diameter on the palatal side ( Figure 2(d) ). Furthermore, the apical lesion had spread extensively from the palatal apical lesion and reached the apical areas of the central and lateral incisors that were the sites of the chief complaint ( Figure 2(e) ). Based on these results, the clinical diagnostic was that the apical radiolucency of the chief complaint was derived from the apical lesion of the palatal root at the maxillary right first premolar. Therefore, we planned to retreat the root canal of the first premolar, which was considered as the causative tooth. To perform endodontic caries treatment, the connective bridge on the maxillary right molars was cut between the first and second premolars to remove the crown on the first premolar alone. Subsequently, we used a rubber dam and removed the gutta percha in the buccal roots using ProTaper Retreatment files D1 and D2 (Dentsply Sirona Endodontics, Ballaigues, Switzerland) and a #10 K-file (Dentsply Sirona Endodontics) to locate and measure the working length of the buccal and palatal root canals with an electronic apex locator (Root ZX; J. Morita Mfg. Corp., Kyoto, Japan). WaveOne Gold (Dentsply Sirona Endodontics) was then used to expand the root canal to have a large tip size. We used 6% sodium hypochlorite for all intermediary procedures. After root canal enlargement, we used 17% ethylenediaminetetraacetic acid (EDTA) for 1 min and ultrasound with an EndoActivator (Dentsply Sirona Endodontics) to irrigate the root canal wall dentin. The fluid inside the root canal was then aspirated and dried with a paper point, and calcium hydroxide (Fujifilm Wako Pure Chemical Corporation, Osaka, Japan) mixed with sterilized water was applied and given a temporary hydraulic seal with Caviton EX (GC Corp., Tokyo, Japan). On the second visit (four weeks later), root canal filling was performed using a resin sealer (AH Plus; Dentsply Sirona Endodontics) with the core carrier method (Gutta Core, Dentsply Sirona Endodontics). Abutment was prepared using a flowable resin composite, and a temporary crown was placed ( Figure 3(a) ). This treatment led to the disappearance of swelling at the maxillary right central and lateral incisors approximately two weeks postoperatively, and intraoral periapical radiographs showed a tendency of disappearance of the apical radiolucency approximately six months postoperatively ( Figure 3(c) ). After three years, intraoral periapical radiographs and CBCT images showed that apical radiolucency almost disappeared around the maxillary first premolar and incisors (Figures 3(b) , 3(d) , 4(a) , 4(b) , and 4(c) ). The mobility of the central and lateral incisors improved to grade 0, and the dental pulp was preserved, leaving vital teeth with no symptoms ( Figure 3(e) ).
| 4.121094
| 0.966797
|
sec[1]/p[0]
|
en
| 0.999997
|
33489383
|
https://doi.org/10.1155/2020/8830524
|
[
"apical",
"root",
"maxillary",
"canal",
"incisors",
"premolar",
"radiolucency",
"lesion",
"incisor",
"dentsply"
] |
[
{
"code": "BC46&XA7XU8",
"title": "Apical thrombosis"
},
{
"code": "DA09.71",
"title": "Chronic apical periodontitis"
},
{
"code": "BC43.5",
"title": "Stress-induced cardiomyopathy"
},
{
"code": "DA09.8",
"title": "Radicular cyst"
},
{
"code": "DA09.62",
"title": "Periapical abscess without sinus"
},
{
"code": "DA07.4",
"title": "Root anomaly"
},
{
"code": "DA0A.3",
"title": "Retained dental root"
},
{
"code": "MD80.Y",
"title": "Other specified symptoms or signs of the orofacial complex"
},
{
"code": "NA0D.06",
"title": "Root fracture"
},
{
"code": "8B9Z",
"title": "Nerve root or plexus disorders, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[DA09.71] Chronic apical periodontitis
Definition: A periapical inflammation characterised by dental granuloma formation.
Also known as: Chronic apical periodontitis | Apical periodontitis NOS | apex periodontitis | periapical infection NOS | Apical or periapical granuloma
[BC43.5] Stress-induced cardiomyopathy
Definition: Stress-induced or Takotsubo cardiomyopathy is a disease of the myocardium characterised by episodes of acute onset, reversible left ventricular apical wall motion abnormalities mimicking acute myocardial infarction, but with non-specific electrocardiographic ST elevation and T wave changes, and minimal myocardial enzymatic release, in the absence of coronary stenosis.
Also known as: Stress-induced cardiomyopathy | Takotsubo cardiomyopathy | stress cardiomyopathy | broken heart syndrome | apical ballooning syndrome
Includes: Takotsubo cardiomyopathy
[DA09.8] Radicular cyst
Definition: The radicular cyst is defined as an area of chronic inflammation exhibiting a closed central cavity surrounded by an epithelial lining.
Also known as: Radicular cyst | apical cyst | apical radicular cyst | periradicular cyst | radiculodental cyst
Excludes: lateral periodontal cyst
[DA09.62] Periapical abscess without sinus
Also known as: Periapical abscess without sinus | apical abscess | apical tooth abscess | suppurative apical periodontitis | apex abscess
[DA07.4] Root anomaly
Definition: Common presence of fused roots showed by X-ray film that short or long root, supernumerary root, or fused roots. These root anomalies are commonly seen in permanent molars, especially in third molars which are the most anomaly in one fused root, 2 or 3 fused roots, even 4 fused roots, round apical root or dilacerations.
Also known as: Root anomaly | Supernumerary roots
[DA0A.3] Retained dental root
Definition: Complete or fragment of root structure that remains in the jaw usually as result of fracture during the corresponding tooth extraction procedure.
Also known as: Retained dental root | dental root | dental root retention
[MD80.Y] Other specified symptoms or signs of the orofacial complex
Also known as: Other specified symptoms or signs of the orofacial complex | Bleeding gums | gum haemorrhage | gingival haemorrhage | gingiva haemorrhage
[NA0D.06] Root fracture
Definition: A fracture involving dentin, cementum and the pulp.
Also known as: Root fracture | Fracture of tooth root
[8B9Z] Nerve root or plexus disorders, unspecified
Also known as: Nerve root or plexus disorders, unspecified
=== GRAPH WALKS ===
--- Walk 1 ---
[DA09.71] Chronic apical periodontitis
Def: A periapical inflammation characterised by dental granuloma formation....
--PARENT--> [DA09.7] Periapical periodontitis
--CHILD--> [DA09.71] Chronic apical periodontitis
Def: A periapical inflammation characterised by dental granuloma formation....
--- Walk 2 ---
[DA09.71] Chronic apical periodontitis
Def: A periapical inflammation characterised by dental granuloma formation....
--PARENT--> [DA09.7] Periapical periodontitis
--CHILD--> [DA09.7Y] Other specified periapical periodontitis
--- Walk 3 ---
[BC43.5] Stress-induced cardiomyopathy
Def: Stress-induced or Takotsubo cardiomyopathy is a disease of the myocardium characterised by episodes of acute onset, reversible left ventricular apical wall motion abnormalities mimicking acute myocard...
--PARENT--> [BC43] Cardiomyopathy
Def: These are myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disea...
--RELATED_TO--> [?] Pacing-induced cardiomyopathy
Def: Pacing-induced cardiomyopathy is ventricular dilation, dysfunction (systolic and/or diastolic) and dyskinesia associated with chronic ventricular pacing in the absence of other causes of cardiomyopath...
--- Walk 4 ---
[BC43.5] Stress-induced cardiomyopathy
Def: Stress-induced or Takotsubo cardiomyopathy is a disease of the myocardium characterised by episodes of acute onset, reversible left ventricular apical wall motion abnormalities mimicking acute myocard...
--PARENT--> [BC43] Cardiomyopathy
Def: These are myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disea...
--EXCLUDES--> [?] Myocarditis
Def: Myocarditis (inflammatory cardiomyopathy) is inflammation of the heart muscle generally in the presence of a dilated cardiomyopathy that results from exposure to either discrete infectious external an...
--- Walk 5 ---
[DA09.8] Radicular cyst
Def: The radicular cyst is defined as an area of chronic inflammation exhibiting a closed central cavity surrounded by an epithelial lining....
--EXCLUDES--> [?] Developmental odontogenic cysts
Def: Cysts derived from odontogenic (tooth forming) tissue, usually containing fluid or semisolid material, which develop during various stages of odontogenesis....
--CHILD--> [?] Dental lamina keratocyst
--- Walk 6 ---
[DA09.8] Radicular cyst
Def: The radicular cyst is defined as an area of chronic inflammation exhibiting a closed central cavity surrounded by an epithelial lining....
--PARENT--> [DA09] Diseases of pulp or periapical tissues
Def: Dental pulp is that part of the tooth located in the centre of the coronal portion underneath dentin and composed of connective tissue, blood vessels and nerve endings.
Periapical tissues are designat...
--CHILD--> [DA09.1] Necrosis of pulp
Def: Necrosis of the dental pulp which clinically does not respond to thermal stimulation; the tooth may be asymptomatic or sensitive to percussion and palpation....
|
[
"[DA09.71] Chronic apical periodontitis\n Def: A periapical inflammation characterised by dental granuloma formation....\n --PARENT--> [DA09.7] Periapical periodontitis\n --CHILD--> [DA09.71] Chronic apical periodontitis\n Def: A periapical inflammation characterised by dental granuloma formation....",
"[DA09.71] Chronic apical periodontitis\n Def: A periapical inflammation characterised by dental granuloma formation....\n --PARENT--> [DA09.7] Periapical periodontitis\n --CHILD--> [DA09.7Y] Other specified periapical periodontitis",
"[BC43.5] Stress-induced cardiomyopathy\n Def: Stress-induced or Takotsubo cardiomyopathy is a disease of the myocardium characterised by episodes of acute onset, reversible left ventricular apical wall motion abnormalities mimicking acute myocard...\n --PARENT--> [BC43] Cardiomyopathy\n Def: These are myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disea...\n --RELATED_TO--> [?] Pacing-induced cardiomyopathy\n Def: Pacing-induced cardiomyopathy is ventricular dilation, dysfunction (systolic and/or diastolic) and dyskinesia associated with chronic ventricular pacing in the absence of other causes of cardiomyopath...",
"[BC43.5] Stress-induced cardiomyopathy\n Def: Stress-induced or Takotsubo cardiomyopathy is a disease of the myocardium characterised by episodes of acute onset, reversible left ventricular apical wall motion abnormalities mimicking acute myocard...\n --PARENT--> [BC43] Cardiomyopathy\n Def: These are myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disea...\n --EXCLUDES--> [?] Myocarditis\n Def: Myocarditis (inflammatory cardiomyopathy) is inflammation of the heart muscle generally in the presence of a dilated cardiomyopathy that results from exposure to either discrete infectious external an...",
"[DA09.8] Radicular cyst\n Def: The radicular cyst is defined as an area of chronic inflammation exhibiting a closed central cavity surrounded by an epithelial lining....\n --EXCLUDES--> [?] Developmental odontogenic cysts\n Def: Cysts derived from odontogenic (tooth forming) tissue, usually containing fluid or semisolid material, which develop during various stages of odontogenesis....\n --CHILD--> [?] Dental lamina keratocyst",
"[DA09.8] Radicular cyst\n Def: The radicular cyst is defined as an area of chronic inflammation exhibiting a closed central cavity surrounded by an epithelial lining....\n --PARENT--> [DA09] Diseases of pulp or periapical tissues\n Def: Dental pulp is that part of the tooth located in the centre of the coronal portion underneath dentin and composed of connective tissue, blood vessels and nerve endings.\nPeriapical tissues are designat...\n --CHILD--> [DA09.1] Necrosis of pulp\n Def: Necrosis of the dental pulp which clinically does not respond to thermal stimulation; the tooth may be asymptomatic or sensitive to percussion and palpation...."
] |
BC46&XA7XU8
|
Apical thrombosis
|
[
{
"from_icd11": "DA09.71",
"icd10_code": "K045",
"icd10_title": "Chronic apical periodontitis"
},
{
"from_icd11": "DA09.8",
"icd10_code": "K048",
"icd10_title": "Radicular cyst"
},
{
"from_icd11": "DA09.62",
"icd10_code": "K047",
"icd10_title": "Periapical abscess without sinus"
},
{
"from_icd11": "DA0A.3",
"icd10_code": "K083",
"icd10_title": "Retained dental root"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G542",
"icd10_title": "Cervical root disorders, not elsewhere classified"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G548",
"icd10_title": "Other nerve root and plexus disorders"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G544",
"icd10_title": "Lumbosacral root disorders, not elsewhere classified"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G549",
"icd10_title": "Nerve root and plexus disorder, unspecified"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G543",
"icd10_title": "Thoracic root disorders, not elsewhere classified"
},
{
"from_icd11": "8B9Z",
"icd10_code": "G54",
"icd10_title": "Nerve root and plexus disorders"
}
] |
K045
|
Chronic apical periodontitis
|
A 63-year-old female patient was admitted to the hospital in January 2019 after physical examination revealed "space occupying the right ureter with hydronephrosis in the right kidney for one month". Colour Doppler ultrasound revealed a 5.0 cm × 1.5 cm hypoechoic region was noted in the abdominal segment of the right ureter. CT revealed : the middle ureteral wall of the right side was thickened with stenosis and occlusion, with local nodular changes of approximately 4.5 cm in length. Cystoscopy of the urethra revealed no obvious abnormalities in the bladder and urethra. Upon urine exfoliative cytology examination, nuclear atypical cells were found. Accompanying transurethral right ureteroscopy biopsy revealed urothelial carcinoma. One week later, transabdominal robot-assisted laparoscopic right nephrectomy + right ureterectomy + bladder wall cuff resection was performed. Postoperative pathological diagnosis was high-grade urothelial carcinoma of the right ureter with squamous cell carcinoma and sarcomatoid carcinoma differentiation. The tumour infiltrated into the serosa of the ureteral wall, but the short end of the ureter, kidney and perirenal fat tissue were not involved. For a half a year after the operation, the patient was followed up regularly every 3 months by cystoscopy, and bladder perfusion was administered for symptomatic treatment to prevent bladder recurrence. No other abnormalities were noted during follow-up. Due to the COVID-19 epidemic, follow-up was interrupted for 8 months. Fifteen months after the operation, she was readmitted to the hospital for "abdominal pain, abdominal distension with no flatulence or defecation for 1 week". CT revealed a cystic shadow of the right pelvis can be seen in the lateral and rectal uterine depression, with blurred edges and unclear boundaries from the adjacent bowel. Tumour indicators CA125 and CA19-9 were 71.8 U/ml and 37.23 U/ml, respectively. The patient had obvious symptoms of gastrointestinal obstruction and required active surgical exploratory decompression treatment, Ileectomy + side-to-side anastomosis + release of intestinal adhesions + bowel decompression was performed. During the operation, a solid mass of 5 cm × 5 cm on the right posterior wall of the right pelvic cavity was fixed in the pelvic wall, and the small intestine were close to the bladder and 25 cm from the ileocecal part. The proximal obstructed small intestine was dilated, the mass was suspected of tumour recurrence. After communicating with the patient about their condition, the patient’s family requested that resection not be considered at that time. The pathological diagnosis was as follows: "ileum": consistent with secondary urothelial carcinoma. The maximum diameter of the tumour was approximately 4.5 cm, and it infiltrated the whole layer of the intestinal wall. There was no tumour invasion at the incisal margin, but tumour metastasis was noted in the peri-intestinal lymph nodes around the intestine (1/2). Molecular examination revealed no FGFR alteration was detected on the pathological slides, so she can't participate in clinical trials of targeted drug Erdafitinib in hospitals. Follow-up of CT showed : a patchy soft tissue shadow was observed adjacent to the right common iliac artery, and an irregular soft tissue mass was noted on the right side of the pelvis. The dorsal segment of the left lower lobe and the posterior segment of the right upper lobe were considered for lung metastasis. The patient was enrolled in a phase III clinical trial for the treatment of locally advanced or metastatic urothelial cancer, and tislelizumab immunotherapy combined with carboplatin + gemcitabine chemotherapy was administered every 3 weeks for a total of 4 cycles, but the effect was not optimal. Re-examination of chest and abdomen CT 20 at months after surgery revealed multiple groups of lymph node metastases in the retroperitoneum and in multiple organs, such as the liver, intestine, bladder, lumbar spine, pelvis, and left lung. She died of multiple organ failure 19 months after surgery. Fig. 1 The wall of the middle section of the right ureter is obviously thickened, with stenosis, occlusion, and local nodular changes observed Fig. 2 High-grade urothelial carcinoma of the right ureter with differentiation of squamous cell carcinoma and sarcomatoid carcinoma Fig. 3 A cystic shadow can be seen on the right side of the pelvis and the rectum and uterus, with blurred edges and unclear boundaries from the adjacent bowel Fig. 4 Diagnosis of secondary urothelial carcinoma in pathological specimens of the ileum Fig. 5 Irregular soft tissue mass shadows on the right side of the pelvis. Tumour metastasis with invasion of the inferior vena cava and right common iliac artery was considered Fig. 6 There is a mass shadow in the dorsal segment of the left lower lobe, approximately 35 × 24 × 32 mm in size, with lobes, cavities, uneven wall thickness, and enhancement Fig. 7 Tumour invades and wraps right iliac blood vessel Fig. 8 Retroperitoneal soft tissue density shadows, multiple retroperitoneal lymph nodes, pelvic, intestinal, and bladder lesions, and metastases were considered
| 3.869141
| 0.98291
|
sec[1]/p[0]
|
en
| 0.999997
|
33612111
|
https://doi.org/10.1186/s12893-021-01099-1
|
[
"carcinoma",
"wall",
"tumour",
"bladder",
"ureter",
"side",
"urothelial",
"tissue",
"pelvis",
"segment"
] |
[
{
"code": "2D41",
"title": "Unspecified carcinoma of unspecified site"
},
{
"code": "2C3Y",
"title": "Other specified malignant neoplasms of skin"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2C25.5",
"title": "Unspecified malignant epithelial neoplasm of bronchus or lung"
},
{
"code": "2C90.Y",
"title": "Other specified malignant neoplasms of kidney, except renal pelvis"
},
{
"code": "LB0Y",
"title": "Other specified structural developmental anomalies of the diaphragm, abdominal wall or umbilical cord"
},
{
"code": "PA82",
"title": "Unintentional striking against stationary object"
},
{
"code": "NB50.Y&XA3KX0&XJ1C6",
"title": "Haematoma of abdominal wall"
},
{
"code": "DC51.1",
"title": "Peritoneal adhesions"
},
{
"code": "LB73.1Z",
"title": "Structural developmental anomalies of chest wall, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[2D41] Unspecified carcinoma of unspecified site
Also known as: Unspecified carcinoma of unspecified site | carcinoma of unspecified primary site | carcinoma NOS | Carcinoma in polyp of unspecified site | Carcinoma with apocrine metaplasia of unspecified site
[2C3Y] Other specified malignant neoplasms of skin
Also known as: Other specified malignant neoplasms of skin | Malignant neoplasm of eyelid NOS | Malignant pilonidal cyst | Radiotherapy-induced skin malignancy | Cutaneous carcinoma
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2C25.5] Unspecified malignant epithelial neoplasm of bronchus or lung
Also known as: Unspecified malignant epithelial neoplasm of bronchus or lung | unspecified carcinoma of bronchus or lung | Metastatic lung carcinoma [primary lung carcinoma spreading elsewhere] | Metastatic carcinoma of lung [primary carcinoma of lung spreading elsewhere] | Lung carcinoma
[2C90.Y] Other specified malignant neoplasms of kidney, except renal pelvis
Also known as: Other specified malignant neoplasms of kidney, except renal pelvis | Congenital mesoblastic nephroma | Nephroblastoma | Wilms tumour of kidney | Wilms tumour of unspecified site
Includes: Nephroblastoma
[LB0Y] Other specified structural developmental anomalies of the diaphragm, abdominal wall or umbilical cord
Also known as: Other specified structural developmental anomalies of the diaphragm, abdominal wall or umbilical cord | Congenital deformity of abdominal wall | abdominal wall defect NOS
[PA82] Unintentional striking against stationary object
Also known as: Unintentional striking against stationary object | striking against stationary object | striking against or struck by other objects | Walked into wall
[DC51.1] Peritoneal adhesions
Definition: Disorders of peritoneum sticking by scar tissue or fibrosis
Also known as: Peritoneal adhesions | abdominal adhesion | adhesive peritoneal band | peritoneal adhesion | peritoneal band
Excludes: Adhesions of large intestine with obstruction | Postprocedural pelvic peritoneal adhesions | Intestinal adhesions or bands of small intestine with obstruction
[LB73.1Z] Structural developmental anomalies of chest wall, unspecified
Also known as: Structural developmental anomalies of chest wall, unspecified | Structural developmental anomalies of chest wall | Malformations of chest wall
=== GRAPH WALKS ===
--- Walk 1 ---
[2D41] Unspecified carcinoma of unspecified site
--PARENT--> [?] Malignant neoplasms of ill-defined or unspecified primary sites
--PARENT--> [?] Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
--- Walk 2 ---
[2D41] Unspecified carcinoma of unspecified site
--PARENT--> [?] Malignant neoplasms of ill-defined or unspecified primary sites
--CHILD--> [2D40] Adenocarcinoma of unspecified site
Def: A common cancer characterised by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to ...
--- Walk 3 ---
[2C3Y] Other specified malignant neoplasms of skin
--PARENT--> [?] Malignant neoplasms of skin
Def: A primary or metastatic tumour involving the skin. Primary malignant skin tumours most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or me...
--EXCLUDES--> [?] Metastatic malignant neoplasm involving skin
Def: Involvement of the skin by metastatic spread from a known or unknown primary malignant neoplasm. The secondary deposit may result from local migration of malignant cells, or from regional lymphatic or...
--- Walk 4 ---
[2C3Y] Other specified malignant neoplasms of skin
--PARENT--> [?] Malignant neoplasms of skin
Def: A primary or metastatic tumour involving the skin. Primary malignant skin tumours most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or me...
--EXCLUDES--> [?] Carcinoma in situ of skin
Def: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis....
--- Walk 5 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs
--- Walk 6 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs
|
[
"[2D41] Unspecified carcinoma of unspecified site\n --PARENT--> [?] Malignant neoplasms of ill-defined or unspecified primary sites\n --PARENT--> [?] Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues",
"[2D41] Unspecified carcinoma of unspecified site\n --PARENT--> [?] Malignant neoplasms of ill-defined or unspecified primary sites\n --CHILD--> [2D40] Adenocarcinoma of unspecified site\n Def: A common cancer characterised by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to ...",
"[2C3Y] Other specified malignant neoplasms of skin\n --PARENT--> [?] Malignant neoplasms of skin\n Def: A primary or metastatic tumour involving the skin. Primary malignant skin tumours most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or me...\n --EXCLUDES--> [?] Metastatic malignant neoplasm involving skin\n Def: Involvement of the skin by metastatic spread from a known or unknown primary malignant neoplasm. The secondary deposit may result from local migration of malignant cells, or from regional lymphatic or...",
"[2C3Y] Other specified malignant neoplasms of skin\n --PARENT--> [?] Malignant neoplasms of skin\n Def: A primary or metastatic tumour involving the skin. Primary malignant skin tumours most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or me...\n --EXCLUDES--> [?] Carcinoma in situ of skin\n Def: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis....",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs"
] |
2D41
|
Unspecified carcinoma of unspecified site
|
[
{
"from_icd11": "2E6Z",
"icd10_code": "D098",
"icd10_title": "Carcinoma in situ of other specified sites"
},
{
"from_icd11": "2E6Z",
"icd10_code": "D099",
"icd10_title": "Carcinoma in situ, unspecified"
},
{
"from_icd11": "2E6Z",
"icd10_code": "D00-D09",
"icd10_title": ""
},
{
"from_icd11": "2E6Z",
"icd10_code": "D09",
"icd10_title": "Carcinoma in situ of other and unspecified sites"
},
{
"from_icd11": "2E6Z",
"icd10_code": "D097",
"icd10_title": ""
},
{
"from_icd11": "PA82",
"icd10_code": "W2209XA",
"icd10_title": "Striking against other stationary object, initial encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W2201XA",
"icd10_title": "Walked into wall, initial encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W2211XA",
"icd10_title": "Striking against or struck by driver side automobile airbag, initial encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W228XXS",
"icd10_title": "Striking against or struck by other objects, sequela"
},
{
"from_icd11": "PA82",
"icd10_code": "W2203XD",
"icd10_title": "Walked into furniture, subsequent encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W2203XA",
"icd10_title": "Walked into furniture, initial encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W228XXD",
"icd10_title": "Striking against or struck by other objects, subsequent encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W2212XA",
"icd10_title": "Striking against or struck by front passenger side automobile airbag, initial encounter"
},
{
"from_icd11": "PA82",
"icd10_code": "W2209XS",
"icd10_title": "Striking against other stationary object, sequela"
},
{
"from_icd11": "PA82",
"icd10_code": "W228XXA",
"icd10_title": "Striking against or struck by other objects, initial encounter"
}
] |
D098
|
Carcinoma in situ of other specified sites
|
The index patient was born at a gestational age of 34 +5 weeks via emergent cesarean section because of maternal preeclampsia. His birth weight was 1.54 kg, and he was admitted to a neonatal intensive care unit for 1 month. He was readmitted for poor weight gain and unexplained pancytopenia at the age of 5 months. He was hypotonic and had delayed motor milestones. Laboratory tests indicated elevated liver enzymes and tubulopathy. By the age of 14 months, liver dysfunction had progressed to hepatic failure with cirrhotic changes, as confirmed by liver biopsy . Respiratory infections which required mechanical respiratory support and combined acute azotemia occurred repeatedly from the beginning of hospitalization, and he became dependent on 24-h oxygen at the age of 12 months. Computed tomography of the chest revealed extensive bilateral ground-glass opacity in the lungs. Lung biopsy performed at 19 months of age indicated diffuse interstitial thickening and fibrosis with focal cystic change and mild lymphocytic infiltration . Magnetic resonance imaging of the brain indicated brain atrophy at 11 months of age , and brain sonography performed at 20 months of age revealed increased echogenicity in both the basal ganglia, the pontine tegmentum and the dentate nucleus, suggesting calcification . He was hospitalized for over 2 years and was on a waiting list for liver and lung transplantations. Exome sequencing (ES) identified novel compound heterozygous variants, c.1040C > T (P347L) and c.1424G > A (R475Q), in FARSA (Additional file 1 ). After molecular diagnosis and comprehensive counselling, the parents declined to continue life-sustaining treatment, and the patient died at the age of 28 months. We identified 4 additional patients with FARSA variants through a literature review (Table 1 ) . All patients exhibited the common but various degrees of clinical symptoms of failure to thrive, hepatic dysfunction and progressive interstitial lung disease, although the age of onset and progression varied among them. The phenotypic comparison based on different literatures was challenging because authors might describe patients from different viewpoints in concise text. We compare the phenotypes based on some keys such as major organ involvements and their onset age, developmental milestones, final basic performance, and necessity of organ transplantations. The index patient had been bedridden throughout his life, and his hepatic and pulmonary dysfunction required organ transplantations despite of intensive care for 2 years. Therefore we decided the index case showed the most severe clinical course compared with other cases, except the Patient 4, who died of respiratory failure at 1.3 years old. To understand the molecular basis of variants, we performed a structural analysis and biochemical characterization of each variant in FARSA . Fig. 1 Pathologic and imaging findings of the patient. a Liver biopsy indicated periportal fibrosis and diffuse infiltration of inflammatory cells. b Lung tissues showed interstitial fibrosis with alveolar thickening. c – e Sequential chest CT revealed progressive diffuse ground-grass opacity. f – g Brain imaging indicated progressive brain atrophy, h bilateral calcifications at the basal ganglia (arrows) Table 1 Clinical features of patients with FARSA-related disorder Patient 1 (Present study) Patient 2 (Krenke et al.) Patient 3 (Schuch et al.) Patient 4 (Schuch et al.) Patient 5 (Schuch et al.) Sex Male Male Female Female Male Age at last examination Died at 28 months 15 years 17 years Died at 1.3 years Died at 12.9 years FARSA genotype Variant 1 c.1424G > A (R475Q) c.776 T > C (F256L) c.1210C > T (R404C) c.883C > T (R295W) c.829 T > G (F277V) Variant 2 c.1040C > T (P347L) c.1230C > A (N410K) c.1254G > C (E418D) c.883C > T (R295W) c.829 T > G (F277V) Central nervous system Neonatal hypotonia + + + + – Motor delay + + + + – Speech delay + – + + – Brain imaging Diffuse atrophy and calcifications at both deep grey matter Subcortical calcifications Periventricular cysts Multiple subcortical white matter lesions Elongated brain arteries Normal by 1 month Arachnoid cyst Nutrition and growth Feeding intolerance + + – + – Poor weight gain + + + + + Vomiting and diarrhoea + + – + – Lung involvement Recurrent respiratory infection + + + + + Interstitial lung disease + + + + + Cholesterol pneumonitis – + + + + Cystic lung disease – – – – + Others Renal involvement Proteinuria + – – – – Tubulopathy + – – + – Vesicourethral reflux – + – – – Others Increased renal echogenicity – – Nephrolithiasis Hepatic involvement Abnormal liver function + + + + + Hepatosplenomegaly + + + + – Liver steatosis + + + + – Liver fibrosis + – – Hormonal insufficiency Subclinical hypothyroidism Adrenal insufficiency Hypopituitarism Growth hormone resistance – Growth hormone deficiency Dysmorphism/malformation – Deep-set eyes, elfin-like face – – – Skeletal involvement – Scoliosis, arachnodactyly, pectus carinatum Hyperflexible joints Arachnoid fingers – Pectus carinatum, hyperflexible joint Others Pancytopenia Left inguinal hernia Microcytic anaemia – Intermittent nystagmus Sensorineural hearing loss
| 4.257813
| 0.630371
|
sec[1]/sec[0]/p[0]
|
en
| 0.999996
|
PMC9344665
|
https://doi.org/10.1186/s13023-022-02457-9
|
[
"liver",
"lung",
"brain",
"farsa",
"died",
"hepatic",
"respiratory",
"interstitial",
"fibrosis",
"imaging"
] |
[
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
},
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "LA75.1",
"title": "Agenesis of lung"
},
{
"code": "CA40.Z",
"title": "Pneumonia, organism unspecified"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "NB32.3Y",
"title": "Other injury of lung"
}
] |
=== ICD-11 CODES FOUND ===
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[LA75.1] Agenesis of lung
Definition: This refers to the absence or rudimentary residua of an undeveloped lung.
Also known as: Agenesis of lung | Pulmonary agenesis | absence of lung | aplasia of lung | apulmonism
[CA40.Z] Pneumonia, organism unspecified
Also known as: Pneumonia, organism unspecified | Pneumonia | infectious pneumonia | PN - [pneumonia] | lobar pneumonia NOS
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[NB32.3Y] Other injury of lung
Also known as: Other injury of lung | Haematoma of lung | Traumatic hydropneumothorax | Acute traumatic lung congestion | Rupture of lung
=== GRAPH WALKS ===
--- Walk 1 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--RELATED_TO--> [?] Metabolic or transporter liver disease
--- Walk 2 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--RELATED_TO--> [?] Viral hepatitis
Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...
--- Walk 3 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Drug-induced or toxic liver disease
Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....
--- Walk 4 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Acute or subacute hepatic failure
Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....
--- Walk 5 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium
Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium....
--- Walk 6 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium
Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium....
|
[
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --RELATED_TO--> [?] Metabolic or transporter liver disease",
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --RELATED_TO--> [?] Viral hepatitis\n Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Drug-induced or toxic liver disease\n Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Acute or subacute hepatic failure\n Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium\n Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium....",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium\n Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium...."
] |
DB9Z
|
Diseases of liver, unspecified
|
[
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K762",
"icd10_title": "Central hemorrhagic necrosis of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K70-K77",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K778",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K72",
"icd10_title": "Hepatic failure, not elsewhere classified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K76",
"icd10_title": "Other diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
}
] |
K7681
|
Hepatopulmonary syndrome
|
Physical examination on admission showed a child with a weight of 10 kg, body temperature of 38.5 °C, blood pressure of 79/41 mmHg, and a heart rate of 157 beats/min. Her weight was reduced from 11 kg (25th percentile) to 10 kg (10th percentile) over the past month alone. Immediately after admission, tracheal intubation was performed because of severe dyspnea, and she was transferred to a pediatric intensive care unit (PICU). Arterial blood gas analysis in the PICU showed PaO 2 of 60 mmHg, PaCO 2 of 59 mmHg, and pH 7.27 under mechanical ventilation with FiO 2 of 1.0, which resulted in a PaO 2 /FiO 2 (P/F) ratio of 60 mmHg and an oxygenation index (OI) of 29 (Table 1 ). A chest X-ray showed bilateral infiltration without findings of heart failure . Laboratory findings were as follows: white blood cell (WBC) count, 7000 cells/μl; red blood cell (RBC) count, 430 × 10 3 cells/μl; platelet (PLT) count, 223 × 10 3 cells/μl; aspartate aminotransferase (AST), 60 U/L; alanine aminotransferase (ALT), 13 U/L; blood urea nitrogen (BUN), 18.0 mg/dL; creatinine (Cre), 32 μmol/L; c-reactive protein (CRP), 7.3 mg/dL; fibrinogen, 2.79 g/L; and prothrombin time (PT), 16.1 s (Table 2 ). The results of a rapid influenza test were negative. Genomes of mycobacterium TB and cytomegalovirus (CMV) were detected in tracheal lavage fluid (TLF) by real-time polymerase chain reaction (rPCR) assay. Acid fast bacilli smear and culture were both positive. She was diagnosed as having severe ARDS that developed from TB pneumonia, and the standard anti-tuberculous drugs: rifampicin, 15 mg/kg/day; isoniazid, 10 mg/kg/day; pyrazinamide, 30 mg/kg/day; ethambutol, 20 mg/kg/day were administered. We also used colistin and levofloxacin for not only nosocomial infection, but also mycoplasma infection, which we could not rule out. However, her respiratory and circulatory conditions deteriorated despite high-frequency oscillating ventilation (HFO), vasopressor support (noradrenaline at 0.2 μg/kg/min), and administration of 1 g/kg of immunoglobulin. On the third day after admission, the patient’s International Society on Thrombosis and Hemostasis DIC score had increased to 5 . For the treatment of DIC, 380 U/kg of rTM was administered as an intravenous drip infusion for 6 consecutive days. After administration of rTM was completed, OI gradually decreased, and the mechanical ventilation mode was changed from HFO to synchronized intermittent mandatory ventilation . DIC score also gradually decreased. We measured plasma levels of soluble receptor for advanced glycan end products (sRAGE) and high mobility group box 1 (HMGB-1) before and after rTM administration, because increased levels of sRAGE and HMGB-1 are associated with death in patients with ARDS . After administration of rTM, HMGB-1 and sRAGE decreased , and inflammatory biomarkers, including interferon-gamma (IFN-γ) and interleukin-6 (IL-6), also decreased . Throughout the administration of rTM, there was no bleeding-related and other adverse event. Although severe ARDS (P/F ratio ≦ 100 mmHg) was sustained for 19 days, the patient’s OI and P/F ratio improved gradually , and she was extubated on the 27th day after admission. Although there was still a diffuse pattern in the chest X-ray just after extubation , her fever went down and her respiratory condition was stable (P/F ratio: 325, OI: 3). Therefore, she was moved from the PICU to the infectious disease department. The severe ARDS with DIC was successfully treated, and she was discharged from hospital on the 33rd day after admission. Table 1 Changes in vital sings Days after admission 1 st 3 rd 4 th 5 th 6 th 7 th 8 th 9 th 10 th 27 th Oxygenation Index 36 29 66 61.5 66.7 53 53.3 52 32 3 Ventilation mode PRVC HFO SIMV Extubation Blood Pressure (mmHg) 79/41 82/51 94/49 89/45 109/60 100/49 103/66 105/60 75/45 98/60 Heart Rate (bpm) 126 157 149 127 128 128 158 165 156 130 Body Temperature (°C) 38.5 38.5 38.2 38.6 38.8 38.6 39 39.3 39.7 36.7 PRVC Pressure regulated volume control, HFO high frequency oscillating ventilation, SIMV synchronized intermittent mandatory ventilation Fig. 1 Chest X-ray on admission to PICU Table 2 Changes in laboratory data Days after admission 1 st 3 rd 4 th 5 th 6 th 7 th 8 th 9 th 10 th 27 th WBC 7 6.7 3.7 6 5 6.6 10.5 12.2 7.7 13 Plt 223 153 76 65 60 67 81 142 123 291 AST (U/L) 60 70 92 92 87 87 73 73 95 170 ALT (U/L) 13 16 17 17 14 15 13 14 16 81 Cre (μmol/L) 32 50 45 52 47 43 41 48 41 39 BUN (mg/dL) 18 18 22.8 27 18.6 18 22 18 15 12 Fibrinogen (g/L) 2.79 2.11 2.05 2.1 2.3 1.53 0.8 0.75 2.22 4 D-dimer(ng/mL) 1140 5659 1212 1133 1316 1195 1250 6841 8442 916 PT (sec.) 16.1 23.3 20.9 19.4 16.6 18.4 22 16.4 13.7 10.9 DIC score 3 5 5 4 5 6 5 3 3 1 CRP (mg/dL) 7.3 13.0 12.2 15.8 4.7 3.9 2.6 Fig. 2 Changes in Oxygenation Index (OI) and PaO 2 /FiO2 (PF) ratio after admission to PICU Fig. 3 Changes in sRAGE and HMGB-1 before and after administration of rTM. sRAGE, soluble receptor for advanced glycan end products; HMGB-1, high mobility group box 1 Fig. 4 Changes in INF-γ and IL-6 before and after administration of rTM. INF-γ, interferon-gamma; IL-6, interleukin-6 Fig. 5 Chest X-ray just after extubation
| 4.046875
| 0.966797
|
sec[1]/p[1]
|
en
| 0.999998
|
29970013
|
https://doi.org/10.1186/s12879-018-3215-5
|
[
"ventilation",
"administration",
"blood",
"mmhg",
"picu",
"srage",
"hmgb",
"changes",
"chest",
"ards"
] |
[
{
"code": "MD11.Y",
"title": "Other specified abnormalities of breathing"
},
{
"code": "MD11.7",
"title": "Hyperventilation"
},
{
"code": "PK81.0",
"title": "Ventilation associated with injury or harm in therapeutic use"
},
{
"code": "QB41",
"title": "Dependence on respirator"
},
{
"code": "CA70.7",
"title": "Air conditioner or humidifier lung"
},
{
"code": "PL14.0",
"title": "Non-administration of necessary drug"
},
{
"code": "3B51",
"title": "Acquired fibrinolytic defects"
},
{
"code": "PL13.50",
"title": "Incorrect route of drug or medicament, as mode of injury"
},
{
"code": "PL13.52",
"title": "Incorrect timing of drug or medicament, as mode of injury"
},
{
"code": "QA01.Z",
"title": "Examination or encounter for administrative purposes, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[MD11.Y] Other specified abnormalities of breathing
Also known as: Other specified abnormalities of breathing | Bradypnoea | Choking sensation | Hypoventilation | hypoventilation syndrome NOS
[MD11.7] Hyperventilation
Definition: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the normal range of 37 to 43 mm Hg. Hyperventilation should be distinguished from tachypnoea, an increase in respiratory frequency, and from hyperpnea, an increase in minute volume of ventilation.
Also known as: Hyperventilation | hyperventilating | overbreathing | HV - [hyperventilation] | increased respiratory rate
[PK81.0] Ventilation associated with injury or harm in therapeutic use
Also known as: Ventilation associated with injury or harm in therapeutic use | complication during or following ventilation | Ventilator associated pneumonia | VAP - [ventilator associated pneumonia] | respirator associated pneumonia
Excludes: Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
[QB41] Dependence on respirator
Also known as: Dependence on respirator | dependence on iron lung | dependence on respiratory ventilator
[CA70.7] Air conditioner or humidifier lung
Definition: A form of the sick building syndrome caused by organisms that contaminate humidifiers and the piping of air conditioner ducts. The air conditioner blows cold air containing spores of the organisms throughout the building.
Also known as: Air conditioner or humidifier lung | air conditioner lung | air humidifier pneumonitis | humidifier lung | sauna takers lung
[PL14.0] Non-administration of necessary drug
Also known as: Non-administration of necessary drug | Nonadministration of necessary drug, medicament or biological substance
Excludes: Underdosing, as mode of injury or harm
[3B51] Acquired fibrinolytic defects
Definition: A disease caused by determinants arising after birth, affecting the fibrinolysis system which prevents blood clots from growing and becoming problematic. This disease is characterised by defects in the fibrinolysis system leading to coagulation of the blood. This disease may present with thrombosis.
Also known as: Acquired fibrinolytic defects | Drug-induced fibrinolytic disorder | medicament-induced fibrinolytic disorder | Fibrinolytic disorder due to administration of tissue-type plasminogen activator | Fibrinolytic disorder due to administration of tPA - [ tissue-type plasminogen activator]
[PL13.50] Incorrect route of drug or medicament, as mode of injury
Also known as: Incorrect route of drug or medicament, as mode of injury | wrong route of administration of drug | route error | administration error involving route of drug | medication error involving route of drug
Excludes: Overdose of substance, as mode of injury or harm
[PL13.52] Incorrect timing of drug or medicament, as mode of injury
Also known as: Incorrect timing of drug or medicament, as mode of injury | wrong timing of drug | timing error in giving drug | timing mistake in administration of drug | administration error involving timing of drug
Excludes: Problem with delayed treatment | Overdose of substance, as mode of injury or harm
[QA01.Z] Examination or encounter for administrative purposes, unspecified
Also known as: Examination or encounter for administrative purposes, unspecified | Examination or encounter for administrative purposes
=== GRAPH WALKS ===
--- Walk 1 ---
[MD11.Y] Other specified abnormalities of breathing
--PARENT--> [MD11] Abnormalities of breathing
Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....
--EXCLUDES--> [?] Respiratory failure of newborn
Def: Acute or chronic respiratory failure in a newborn. Neonates in acute respiratory failure require respiratory support....
--- Walk 2 ---
[MD11.Y] Other specified abnormalities of breathing
--PARENT--> [MD11] Abnormalities of breathing
Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....
--EXCLUDES--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 3 ---
[MD11.7] Hyperventilation
Def: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the ...
--PARENT--> [MD11] Abnormalities of breathing
Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....
--EXCLUDES--> [?] Respiratory distress of newborn
Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....
--- Walk 4 ---
[MD11.7] Hyperventilation
Def: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the ...
--PARENT--> [MD11] Abnormalities of breathing
Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....
--CHILD--> [MD11.0] Apnoea
--- Walk 5 ---
[PK81.0] Ventilation associated with injury or harm in therapeutic use
--EXCLUDES--> [?] Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
--EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical procedure
--- Walk 6 ---
[PK81.0] Ventilation associated with injury or harm in therapeutic use
--EXCLUDES--> [?] Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
--CHILD--> [?] Embolisation without injury or harm
Def: An embolisation without documented injury or harm occurs when a solid object within the venous or arterial circulation propagates to a distal location and becomes lodged there....
|
[
"[MD11.Y] Other specified abnormalities of breathing\n --PARENT--> [MD11] Abnormalities of breathing\n Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....\n --EXCLUDES--> [?] Respiratory failure of newborn\n Def: Acute or chronic respiratory failure in a newborn. Neonates in acute respiratory failure require respiratory support....",
"[MD11.Y] Other specified abnormalities of breathing\n --PARENT--> [MD11] Abnormalities of breathing\n Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....\n --EXCLUDES--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[MD11.7] Hyperventilation\n Def: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the ...\n --PARENT--> [MD11] Abnormalities of breathing\n Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....\n --EXCLUDES--> [?] Respiratory distress of newborn\n Def: A condition characterised by developmental insufficiency of surfactant associated proteins or surfactant production and structural immaturity in the lungs....",
"[MD11.7] Hyperventilation\n Def: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the ...\n --PARENT--> [MD11] Abnormalities of breathing\n Def: Abnormalities of breathing includes dyspnoea, stridor, wheezing, periodic breathing, hyperventilation, mouth breathing, hiccough, sneezing, and other abnormalities of breathing....\n --CHILD--> [MD11.0] Apnoea",
"[PK81.0] Ventilation associated with injury or harm in therapeutic use\n --EXCLUDES--> [?] Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm\n --EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical procedure",
"[PK81.0] Ventilation associated with injury or harm in therapeutic use\n --EXCLUDES--> [?] Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm\n --CHILD--> [?] Embolisation without injury or harm\n Def: An embolisation without documented injury or harm occurs when a solid object within the venous or arterial circulation propagates to a distal location and becomes lodged there...."
] |
MD11.Y
|
Other specified abnormalities of breathing
|
[
{
"from_icd11": "MD11.7",
"icd10_code": "R064",
"icd10_title": "Hyperventilation"
},
{
"from_icd11": "QB41",
"icd10_code": "Z9911",
"icd10_title": "Dependence on respirator [ventilator] status"
},
{
"from_icd11": "QB41",
"icd10_code": "Z991",
"icd10_title": "Dependence on respirator"
},
{
"from_icd11": "CA70.7",
"icd10_code": "J677",
"icd10_title": "Air conditioner and humidifier lung"
},
{
"from_icd11": "PL14.0",
"icd10_code": "Y636",
"icd10_title": "Underdosing and nonadministration of necessary drug, medicament or biological substance"
},
{
"from_icd11": "3B51",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z0289",
"icd10_title": "Encounter for other administrative examinations"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z0281",
"icd10_title": "Encounter for paternity testing"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z0283",
"icd10_title": "Encounter for blood-alcohol and blood-drug test"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z765",
"icd10_title": "Malingerer [conscious simulation]"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z02",
"icd10_title": "Encounter for administrative examination"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z028",
"icd10_title": "Encounter for other administrative examinations"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z029",
"icd10_title": "Encounter for administrative examinations, unspecified"
},
{
"from_icd11": "QA01.Z",
"icd10_code": "Z76",
"icd10_title": "Persons encountering health services in other circumstances"
}
] |
R064
|
Hyperventilation
|
According to the patient, she was apparently well around 9 years ago (the patient herself was not sure about the exact date) when she started developing increased urination, increased thirst, weakness, and occasional dizziness for a couple of months. She then visited a local health care facility near her hometown, where she was examined and sent for some blood and urine investigations (she has misplaced the lab reports, or probably lost them, according to her). According to her, she was told that she has high blood sugar levels and was advised to make some lifestyle modifications, such as dietary changes and increasing physical activities. She was also prescribed medication (she has no records of the medications prescribed then) and was asked to follow up in the next 3 months. Thereafter, she was doing fine with no complaints for a couple of years, and she never followed up with any healthcare facility until around 3–4 years ago , when she presented herself to a healthcare facility in Kathmandu city with complaints of fatigue, severe headaches, pain and discomfort in the abdomen, and occasional dizziness and a feeling of lightheadedness for a couple of months. She also complained of weakness and decreased tolerance for physical activity. Physical examination was unremarkable, and laboratory investigations revealed high blood glucose and serum triglyceride levels (fasting blood glucose: 175 mg/dL; postprandial blood glucose: 193 mg/dL; serum triglyceride: 290 mg/dL). Other investigations were within normal limits (Table 1 ). Table 1 Laboratory findings with normal reference ranges for the blood investigations (done at various times) S. No. Parameters Patient’s reading (reference range) May 2020 1 Fasting blood glucose 175 (70–99) mg/dL 2 Postprandial blood glucose 193 (< 140) mg/dL 3 Total cholesterol 163 (< 200) mg/dL 4 Low-density lipoprotein (LDL) cholesterol 61 (< 100) mg/dL 5 High-density lipoprotein (HDL) cholesterol 44 (< 40: low; 40–59: borderline; > 60: considered protective) mg/dL 6 Triglyceride 290 (50–150) mg/dL 1 January 2021 7 Total leucocyte count (TLC) 11,660 cells/mcL 8 Differential leucocyte count (DLC) N = 76 (40–60), L = 17 (20–40), M = 5 (2–8), E = 1 (1–4), B = 1 (0.5–1)% 9 Erythrocyte sedimentation rate (ESR) 10 (0–20) mm first hour 10 Platelet count 2,80,000 (150,000–450,000) cells/mcL 11 Hematocrit (Hct) 37.7 (38.3–48.6) % 12 Mean corpuscular volume (MCV) 64.4 (80–100) fL 13 Mean hemoglobin concentration (MCH) 21.9 (27–32) pg 14 Mean corpuscular hemoglobin concentration (MCHC) 34 (32–36) gm% or g/dL 15 Red cell distribution width-standard deviation (RDW-SD) 36.1 (40–55) fL 16 Red cell distribution width-coefficient of variation (RDW-CV) 17.3 (11–15) % 17 Postprandial blood glucose 294 (< 140) mg/dL 18 HbA1c 2.1 (< 5.7)% 19 Urea 16.8 (6–20) mg/dL 20 Creatinine (0.6–1.1) mg/dL 21 Sodium 136 (136–145) mEq/L 22 Potassium 4.27 (3.5–5.1) mEq/L 23 Total bilirubin 0.73 (0.2–1.2) mg/dL 24 Direct bilirubin 0.25 (0.0–0.4) mg/dL 25 Alanine transaminase (ALT) 17.9 (< 35) IU/L 26 Aspartate transaminase (AST) 13 (< 35 IU/L) 27 Alkaline phosphatase (ALP) 103 (38–154) U/L 28 Uric acid 5.5 (2.5–6.2) mg/dL 29 Phosphorous 3.24 (2.7–4.5) mg/dL 30 Calcium 10.48 (8.6–10) mg/dL 31 Total protein 7.8 (6–8) g/dL 32 Albumin 4.8 (3.5–5.5) g/dL 33 Thyroid stimulating hormone (TSH) 2.56 (0.5–5) mIU/L 21 January 2021; at NPHL 34 Hemoglobin (Hb) 13.6 (12–16) g/dL 35 Red blood cell (RBC) count 6.2 × 10 6 (3.5–5.0 × 10 6 ) cells/mcL 36 Total leucocyte count (TLC) 13,700 cells/mcL 37 Differential leucocyte count (DLC) N = 77 (40–60), L = 18 (20–40), M = 4 (2–8), E = 1 (1–4), B = 0 (0.5–1)% 38 Platelet count 2.8 × 10 5 (150,000–450,000) cells/mcL 39 Packed cell volume (PCV) 42.1 (38.3–48.6%) 40 Mean corpuscular volume (MCV) 67 (80–100) fL 41 Mean hemoglobin concentration (MCH) 21.7 (27–32) pg 42 Mean corpuscular hemoglobin concentration (MCHC) 32.3 (32–36) g/dL 43 Red cell distribution width–coefficient of variation (RDW-CV) 17.9 (11.0–15.0)% 44 Total cholesterol 163 (< 200 mg/dL) 45 Triglycerides 290 (50–150) mg/dL 46 High-density lipoprotein (HDL) cholesterol 44 (< 40: low; 40–59: borderline; > 60: considered protective) mg/dL 47 Very-low-density lipoprotein (VLDL) cholesterol 58 (2–40) mg/dL 48 Low-density lipoprotein (LDL) cholesterol 61 (< 100) mg/dL 49 Urea 16.8 (6–20) mg/dL 50 Creatinine 0.6 (0.6–1.1) mg/dL 51 Uric acid 5.8 (2.5–6.2) mg/dL 52 Sodium 134.8 (136–145) mEq/L 53 Potassium 4.5 (3.5 -5.1) mEq/L 54 Total bilirubin 1.3 (0.2–1.2) mg/dL 55 Direct bilirubin 0.2 (0.0–0.4) mg/dL 56 Aspartate transaminase (AST) 14.8 (< 35) IU/L 57 Alanine transaminase (ALT) 10.4 (< 35) IU/L 58 Serum iron 88.7 (50–170) mcg/dL 59 Unsaturated iron binding capacity (UIBC) 276.4 (111–343) mcg/dL 60 Total iron binding capacity (TIBC) 365 (300–450) mcg/dL 61 Calcium 9.3 (8.6–10) mg/dL 62 Phosphorus 3.0 (2.7–4.5) mg/dL 63 Creatine kinase 35.0 (34–145) IU/L 64 Lactate dehydrogenase (LDH) 137.5 (< 400) U/L 65 Total protein 8.2 (6–8) g/dL 66 Albumin 4.8 (3.5–5.5) g/dL 67 Albumin/globulin ratio 1 (1.0–1.8) 68 Alkaline phosphatase (ALP) 92.3 (38–154) U/L The values in bold indicate that the parameter is out of range
| 3.951172
| 0.958008
|
sec[1]/p[2]
|
en
| 0.999994
|
38877536
|
https://doi.org/10.1186/s13256-024-04518-y
|
[
"blood",
"total",
"cholesterol",
"count",
"glucose",
"mean",
"lipoprotein",
"cells",
"hemoglobin",
"cell"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "MB5Z",
"title": "Paralytic symptoms, unspecified"
},
{
"code": "LB9B",
"title": "Reduction defects of upper and lower limbs"
},
{
"code": "LA85.1",
"title": "Transposition of the great arteries"
},
{
"code": "LD40.Y",
"title": "Other specified complete trisomies of the autosomes"
},
{
"code": "9D90.6",
"title": "Blindness"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[MB5Z] Paralytic symptoms, unspecified
Also known as: Paralytic symptoms, unspecified | paralysis syndrome | incomplete paralysis | complete paralysis | paresis
[LB9B] Reduction defects of upper and lower limbs
Also known as: Reduction defects of upper and lower limbs | Tetraamelia | Total amelia | Split hand - split foot | Acheiropodia
[LA85.1] Transposition of the great arteries
Definition: A congenital cardiovascular malformation in which the morphologically right ventricle or its remnant connects to the aorta and the morphologically left ventricle or its remnant connects to the pulmonary trunk.
Also known as: Transposition of the great arteries | Discordant ventriculoarterial connection | complete transposition of great vessels | great vessels complete transposition | great vessels transposition
[LD40.Y] Other specified complete trisomies of the autosomes
Also known as: Other specified complete trisomies of the autosomes | Other complete trisomies | entire chromosome trisomy, meiotic nondisjunction | Other trisomy mosaicism | Whole chromosome trisomy, mosaicism disorder
[9D90.6] Blindness
Definition: The numerical definition used for WHO statistics refers to profound, near-total or total loss. The functional definition refers to individuals who have little or no residual vision and who have to rely predominantly on vision substitution skills, i.e. on using senses other than vision (Braille or talking books for reading, a long cane or guide dog for mobility, or touch for manipulation).
Also known as: Blindness | acquired amaurosis | acquired blindness | amaurosis | blindness, both eyes
Includes: visual impairment category 5 | visual impairment categories 4, 5, 6 in both eyes | visual impairment categories 4, 5, 6 in one eye and categories 1, 2, 3 or 9 in the other eye
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--RELATED_TO--> [?] Symptoms, signs or clinical findings of blood, blood-forming organs, or the immune system
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--RELATED_TO--> [?] Symptoms, signs or clinical findings of blood, blood-forming organs, or the immune system
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--EXCLUDES--> [?] Recurrent or persistent glomerular haematuria
Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.1] Finding of cocaine in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --RELATED_TO--> [?] Symptoms, signs or clinical findings of blood, blood-forming organs, or the immune system",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --RELATED_TO--> [?] Symptoms, signs or clinical findings of blood, blood-forming organs, or the immune system",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --EXCLUDES--> [?] Recurrent or persistent glomerular haematuria\n Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.1] Finding of cocaine in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
Table 1 summarizes the main demographic, clinical, and radiological findings in our patient cohort with BCS. A 34-year-old female with essential thrombocythemia (ET) presented to the emergency unit for body weight gain and increase in abdominal circumference; nocturnal pruritus and abdominal pain had been present since pregnancy. Doppler-ultrasound (US) established a diagnosis of BCS. An upper endoscopy (EGD) showed the presence of grade 1 esophageal varices (EV) and mild portal hypertensive gastropathy (PHG). TE evaluation at diagnosis showed LSM and SSM values of 75 kPa at both sides. For the following two years, caudate lobe hypertrophy and a macronodular liver pattern (>2.5 cm) developed. Most importantly, ascites was resistant and intolerant to diuretic therapy, leading to the readmission of the patient for severe hyponatremia and massive pleural effusion. TIPS was thus placed. In the following year, no liver-related complications were registered. EGD showed no signs of EV or PHG. At concomitant TE control, LSM was significantly reduced to 8 kPa, but high values of SSM persisted (65.2 kPa). A 65-year old female with a history of persistent abdominal pain presented with a recent increase in abdominal circumference. The CT scan evaluation provided the diagnosis of BCS. No EV or PHG were shown at EGD. LSM and SSM were both 75 kPa. The hematological evaluation established an ET diagnosis. In the following two years, EGD showed EV grade 1 and the patient developed recurrent episodes of ascites. At the last decompensating event, LSM and SSM were both 75 kPa. Accordingly, TIPS was placed and an evaluation for liver transplant was started. In the following month, the patient underwent OLT and no signs of BCS recurrence have been reported since then. A 25-year-old male with an initial diagnosis of decompensated cryptogenic cirrhosis was referred for OLT evaluation due to severe PH with repeated bleeding episodes. In our unit, Doppler-US showed obliterated hepatic veins (HVs) and signs of severe PH. BCS diagnosis was confirmed at vena cavography. LSM and SSM were both 75 kPa. At EGD controls, EV persisted (G1 with red signs) and PHG became severe. TIPS placement was attempted, but was unsuccessful. Consequently, in the following year, the patient developed numerous decompensating events. During one of these episodes, the bleeding could not be controlled, thus urgent OLT was attempted and successfully carried out. A 52-year-old male was admitted to our unit with suspected BCS. Vena cavography and HV catheterization indicated ICV thrombosis. Liver biopsy highlighted macro-vesicular steatosis, thus ruling out the presence of significant fibrosis. EGD screening revealed the presence of grade 1 gastric varices. In the following months, the patient presented several bleeding episodes which finally led to TIPS placement one year after BCS diagnosis. At TE evaluation before the intervention, LSM and SSM were both 75 kPa. During a follow-up of over ten years, TIPS remained patent and no variceal bleeding or ascites occurred. At TE evaluation, 10-year post-TIPS placement, LSM was 7.3 kPa, while high values of 75 kPa for SSM were reported. A 65-year-old female with BCS diagnosis presented the following medical history: long-standing Polycythemia Vera (PV); initial diagnosis of cryptogenic cirrhosis and idiopathic PH from diffuse nodular regenerative hyperplasia (NRH). Subsequently, serrated stenosis of right and left HVs were demonstrated. After percutaneous transluminal angioplasty (PTA) and TIPS placement, the patient remained compensated and was subsequently lost at follow-up. During evaluation in our center: EGD showed mild PHG, but no EV; US described signs suggestive of advanced liver disease, minimal ascites and normal TIPS flow velocity. However, in the following year, TIPS was obstructed and subsequently compensated by recanalization of the paraumbilical vein. LSM and SSM at this time were both 75 kPa. No events of clinical decompensation were reported in the follow-up although EGD showed the development of grade 1 EV. A 61-year-old female was referred to our center for mild and diffuse abdominal pain. Doppler-US described a narrowed and partly visible right HV. Caudate lobe hypertrophy and macronodules (>2 cm) were also described in the liver. No signs of portal hypertension were present. LSM and SSM were 34.8 kPa and 38.5 kPa, respectively. At follow-up over six years later, no decompensating events had developed. A repeated TE evaluation showed slightly reduced LSM and SSM values. A 23-year-old female with Behçet's disease was referred to our center for persistent fever. At CT-scan assessment, however, stenosed right and left HVs were described. Liver biopsy showed unspecific signs and ruled out significant fibrosis. At Doppler-US, no ascites was present, but a patent paraumbilical vein was observed, as well as a slight splenomegaly. EGD ruled out the presence of EV. LSM and SSM were 14.3 kPa and 47.2 kPa, respectively. During follow-up, no ascites or other hepatic decompensation events developed. At TE control three years after diagnosis, LSM and SSM were 11.8 and 40 kPa respectively.
| 4.109375
| 0.833984
|
sec[1]/p[0]
|
en
| 0.999998
|
30719429
|
https://doi.org/10.1155/2019/1673197
|
[
"tips",
"liver",
"both",
"ascites",
"abdominal",
"doppler",
"presence",
"grade",
"episodes",
"bleeding"
] |
[
{
"code": "FC00.3",
"title": "Acquired deformity of pelvis"
},
{
"code": "EA85.2Y",
"title": "Other specified dermatitis of hands"
},
{
"code": "2B62.Z",
"title": "Malignant neoplasms of other or unspecified parts of tongue, unspecified"
},
{
"code": "2E60.0",
"title": "Carcinoma in situ of lip, oral cavity or pharynx"
},
{
"code": "2E90.1",
"title": "Benign neoplasm of tongue"
},
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[FC00.3] Acquired deformity of pelvis
Also known as: Acquired deformity of pelvis | deformity of pelvis | pelvic deformity | ischium deformity | ilium deformity
Excludes: Maternal care for disproportion | Obstructed labour due to maternal pelvic abnormality | Obstructed labour due to deformed pelvis
[EA85.2Y] Other specified dermatitis of hands
Also known as: Other specified dermatitis of hands | Nummular dermatitis of hands | Discoid hand eczema | Fingertip dermatitis | Fingertip eczema
[2B62.Z] Malignant neoplasms of other or unspecified parts of tongue, unspecified
Also known as: Malignant neoplasms of other or unspecified parts of tongue, unspecified | Malignant neoplasms of other or unspecified parts of tongue | tongue cancer | malignant neoplasm of tip of tongue | primary malignant neoplasm of border of tongue
[2E60.0] Carcinoma in situ of lip, oral cavity or pharynx
Also known as: Carcinoma in situ of lip, oral cavity or pharynx | Carcinoma in situ of labial mucosa or vermilion border | carcinoma in situ of vermilion border of lip | carcinoma in situ of vermilion border of lower lip | carcinoma in situ of vermilion border of upper lip
Excludes: Carcinoma in situ of aryepiglottic fold, laryngeal aspect | Carcinoma in situ of epiglottis nos | Carcinoma in situ of epiglottis, suprahyoid portion
[2E90.1] Benign neoplasm of tongue
Definition: Abnormal growth, without malignant characteristics, of the cells that comprise the tongue.
Also known as: Benign neoplasm of tongue | benign tumour of tongue | Benign neoplasm of base of tongue | benign tumour of base of tongue | benign neoplasm of root of tongue
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
=== GRAPH WALKS ===
--- Walk 1 ---
[FC00.3] Acquired deformity of pelvis
--EXCLUDES--> [?] Maternal care for disproportion
Def: A condition characterised by the provision of health interventions to the mother due to the situation in which the head or body of the fetus is too large to fit through the pelvis of the mother....
--EXCLUDES--> [?] Obstructed labour due to maternal pelvic abnormality
Def: Obstructed labour means that, in spite of strong contractions of the uterus, the fetus cannot descend through the pelvis because there is an insurmountable barrier preventing its descent. Obstruction ...
--- Walk 2 ---
[FC00.3] Acquired deformity of pelvis
--PARENT--> [FC00] Certain specified acquired deformities of musculoskeletal system or connective tissue, not elsewhere classified
--CHILD--> [FC00.1] Acquired deformity of neck
--- Walk 3 ---
[EA85.2Y] Other specified dermatitis of hands
--PARENT--> [EA85.2] Dermatitis of hands
Def: Dermatitis or eczema involving predominantly the hands....
--RELATED_TO--> [?] Vesicular dermatitis of hands
Def: A vesicular eczema of uncertain cause and otherwise known as dyshidrotic eczema or cheiropompholyx localised to the palmar surfaces and sides of the hands and fingers....
--- Walk 4 ---
[EA85.2Y] Other specified dermatitis of hands
--PARENT--> [EA85.2] Dermatitis of hands
Def: Dermatitis or eczema involving predominantly the hands....
--RELATED_TO--> [?] Hyperkeratotic fissured palmar dermatitis
Def: A distinct and common form of hand eczema characterised by highly irritable, scaly, fissured, hyperkeratotic patches on the palms and palmar surfaces of the fingers. It may be accompanied by similar c...
--- Walk 5 ---
[2B62.Z] Malignant neoplasms of other or unspecified parts of tongue, unspecified
--PARENT--> [2B62] Malignant neoplasms of other or unspecified parts of tongue
--EXCLUDES--> [?] Malignant mesenchymal neoplasms
Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...
--- Walk 6 ---
[2B62.Z] Malignant neoplasms of other or unspecified parts of tongue, unspecified
--PARENT--> [2B62] Malignant neoplasms of other or unspecified parts of tongue
--CHILD--> [2B62.1] Malignant neoplasms of lingual tonsil
|
[
"[FC00.3] Acquired deformity of pelvis\n --EXCLUDES--> [?] Maternal care for disproportion\n Def: A condition characterised by the provision of health interventions to the mother due to the situation in which the head or body of the fetus is too large to fit through the pelvis of the mother....\n --EXCLUDES--> [?] Obstructed labour due to maternal pelvic abnormality\n Def: Obstructed labour means that, in spite of strong contractions of the uterus, the fetus cannot descend through the pelvis because there is an insurmountable barrier preventing its descent. Obstruction ...",
"[FC00.3] Acquired deformity of pelvis\n --PARENT--> [FC00] Certain specified acquired deformities of musculoskeletal system or connective tissue, not elsewhere classified\n --CHILD--> [FC00.1] Acquired deformity of neck",
"[EA85.2Y] Other specified dermatitis of hands\n --PARENT--> [EA85.2] Dermatitis of hands\n Def: Dermatitis or eczema involving predominantly the hands....\n --RELATED_TO--> [?] Vesicular dermatitis of hands\n Def: A vesicular eczema of uncertain cause and otherwise known as dyshidrotic eczema or cheiropompholyx localised to the palmar surfaces and sides of the hands and fingers....",
"[EA85.2Y] Other specified dermatitis of hands\n --PARENT--> [EA85.2] Dermatitis of hands\n Def: Dermatitis or eczema involving predominantly the hands....\n --RELATED_TO--> [?] Hyperkeratotic fissured palmar dermatitis\n Def: A distinct and common form of hand eczema characterised by highly irritable, scaly, fissured, hyperkeratotic patches on the palms and palmar surfaces of the fingers. It may be accompanied by similar c...",
"[2B62.Z] Malignant neoplasms of other or unspecified parts of tongue, unspecified\n --PARENT--> [2B62] Malignant neoplasms of other or unspecified parts of tongue\n --EXCLUDES--> [?] Malignant mesenchymal neoplasms\n Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...",
"[2B62.Z] Malignant neoplasms of other or unspecified parts of tongue, unspecified\n --PARENT--> [2B62] Malignant neoplasms of other or unspecified parts of tongue\n --CHILD--> [2B62.1] Malignant neoplasms of lingual tonsil"
] |
FC00.3
|
Acquired deformity of pelvis
|
[
{
"from_icd11": "FC00.3",
"icd10_code": "M955",
"icd10_title": "Acquired deformity of pelvis"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C029",
"icd10_title": "Malignant neoplasm of tongue, unspecified"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C023",
"icd10_title": "Malignant neoplasm of anterior two-thirds of tongue, part unspecified"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C021",
"icd10_title": "Malignant neoplasm of border of tongue"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C028",
"icd10_title": "Malignant neoplasm of overlapping sites of tongue"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C024",
"icd10_title": "Malignant neoplasm of lingual tonsil"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C020",
"icd10_title": "Malignant neoplasm of dorsal surface of tongue"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C02",
"icd10_title": "Malignant neoplasm of other and unspecified parts of tongue"
},
{
"from_icd11": "2B62.Z",
"icd10_code": "C022",
"icd10_title": "Malignant neoplasm of ventral surface of tongue"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0000",
"icd10_title": "Carcinoma in situ of oral cavity, unspecified site"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0001",
"icd10_title": "Carcinoma in situ of labial mucosa and vermilion border"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0002",
"icd10_title": "Carcinoma in situ of buccal mucosa"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0003",
"icd10_title": "Carcinoma in situ of gingiva and edentulous alveolar ridge"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0004",
"icd10_title": "Carcinoma in situ of soft palate"
},
{
"from_icd11": "2E60.0",
"icd10_code": "D0005",
"icd10_title": "Carcinoma in situ of hard palate"
}
] |
M955
|
Acquired deformity of pelvis
|
We present the case of a premenopausal, employed, unmarried, urbanite, nulliparous, 31-year-old patient with a negative personal and familial medical history. In December 2015, she was diagnosed clinically and by imaging with a tumor formation in her left breast, in the lower inner quadrant of 25/13/16 mm. The patient delayed the definite diagnosis by performing the biopsy 1 year later, in November 2016. The pathology examination revealed a hormone-dependent (ER = 90, PR = 30%), Ki67 = 30%, HER2 = 3 + (positive) infiltrative ductal breast carcinoma (IDC), G2, with an “in situ” ductal component of the comedo type. The preoperative assessment consisted of performing a bilateral mammogram and a bilateral breast MRI, thus avoiding the diagnosis of liver metastases at the time of diagnosis. The patient was initially clinically staged T2N0, being considered a nonmetastatic disease. On 8 December 2016, a left breast conserving surgery and a sentinel node biopsy was performed. Postoperative histopathological examination confirmed a infiltrative ductal carcinoma with components of “in situ” breast carcinoma; Nsn = 0/2 lymph nodes examined (pT2Nsn0). Immunohistochemistry (IHC) revealed an RE = 80%, RP = 20%, Ki 67 = 30% and HER2 = 3 + (positive) profile. On the CT scan performed during the pretherapeutic assessment on 19 December 2016, two liver metastases of 31 mm and 12 mm were observed in the 4th and 2nd segment . The CA15-3 tumor marker had a value of 86.8 U/mL. First-line treatment with docetaxel 75 mg/m 2 iv, trastuzumab 600 mg/5 mL sq./21 days and medical ovarian suppression (goserelin 3.6 mg sq./28 days) was initiated. The treatment was well tolerated by the patient, with no significant side effects. The CT scan performed in May 2017, after six cycles of treatment, highlighted a partial response: the liver lesion in the 4th segment had decreased dimensions (15 mm vs. 31 mm), and the lesion in segment II was in complete remission . The treatment was continued for three more cycles. The PET-CT performed in July 2017 described a single liver lesion of 22.3 mm in the 2nd segment, intensely metabolically active (SUV = 6.4) . Transaminases, both after the 6th and 9th cycle, were within normal limits. For the remaining liver injury, the patient performed, in August 2017, two ablation sessions with an MW of 6 and 4 min at 32 W with a temperature set at 96 degrees. Due to the favorable evolution of the disease and the strong desire to have a child, the patient refused to continue any oncological treatment, including ovarian ablation and the recommended hormone therapy (tamoxifen). The psychiatric consultation highlighted an anxious and depressive reaction for which individual and couple psychotherapy sessions were recommended. The patient only attended regular individual psychotherapy sessions, because at that time she had no life partner. Three months later, in January 2018, the CT scan highlighted a progressive disease of the 4th liver segment lesion (from 33 mm to 55 mm) . She was proposed a 2nd-line treatment with the resumption of the ovarian suppression with goserelin, but the patient refused any additional oncological treatment. In July 2018, the patient presented to the clinic after an emergency consultation, being pregnant for 15 weeks and complaining of abdominal pain. Ultrasound revealed multiple hepatic lesions suggestive of metastases. Tumor marker CA 15-3 had a value of 2400 U/mL, and the common liver tests were slightly above the normal limit (AST = 50 U/L; ALAT = 80 U/L, TB = 1.8 mg/dL). Although the patient was informed about the prognosis at this stage of the disease and about the potential vital risks in case of pregnancy, she wanted to keep the pregnancy, being aware of the consequences of this decision on the evolution of the disease and survival. She did not consult with her parents or with her life partner. Psychological counselling was carried out individually only with the patient, who did not want the family present at the counselling sessions. The psychiatric evaluation performed did not find the existence of any psychiatric pathology that would affect her decision making. We proposed the initiation of chemotherapy, but the patient refused, wanting to go abroad for a second-opinion consultation. She hoped that this consultation would give her a lifesaving solution for the clinical situation she was in. At the end of August 2018, the patient was transported to the emergency department with an affected general state, diffuse abdominal pain and liver failure . The abdominal ultrasound that was performed in the OBGYN department revealed a 21-week-old pregnancy halted in evolution, the absence of fetal heartbeat, biometrics corresponding to an 18-week-old pregnancy, amniotic fluid in normal quantity, multiple liver metastases that almost entirely occupied the liver parenchyma and ascites in large quantities. Given the serious general condition and the impossibility of evacuating the pregnancy by surgery (uterine curettage or total hysterectomy) due to the very high risk of anesthetic death, she was transferred to the intensive care unit where she died a few hours later.
| 3.998047
| 0.978516
|
sec[1]/p[0]
|
en
| 0.999997
|
37232822
|
https://doi.org/10.3390/curroncol30050364
|
[
"liver",
"breast",
"segment",
"that",
"pregnancy",
"metastases",
"lesion",
"sessions",
"consultation",
"december"
] |
[
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
},
{
"code": "GB23",
"title": "Certain specified disorders of breast"
},
{
"code": "GB21.Z",
"title": "Inflammatory disorders of breast, unspecified"
},
{
"code": "GB21.Y",
"title": "Other specified inflammatory disorders of breast"
},
{
"code": "QF01.0",
"title": "Acquired absence of breast"
},
{
"code": "GB23.3",
"title": "Atrophy of breast"
}
] |
=== ICD-11 CODES FOUND ===
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
[GB23] Certain specified disorders of breast
Definition: Any disorder of the breast or breast tissue, characterised by pathological changes, not classified elsewhere.
Also known as: Certain specified disorders of breast | disease of breast | mastopathy
[GB21.Z] Inflammatory disorders of breast, unspecified
Also known as: Inflammatory disorders of breast, unspecified | Inflammatory disorders of breast | breast inflammation | inflammatory breast disease | mastitis NOS
[GB21.Y] Other specified inflammatory disorders of breast
Also known as: Other specified inflammatory disorders of breast | Breast antibioma | Infective mastitis | acute infective mastitis | nonpuerperal infective mastitis
[QF01.0] Acquired absence of breast
Also known as: Acquired absence of breast | absence of breast | mastectomy status | Acquired absence of breast, partial | Acquired absence of breast, total
[GB23.3] Atrophy of breast
Definition: A condition of the breast, caused by apoptosis of the cells commonly due to prolonged estrogen reduction, diminished cellular proliferation, decreased cellular volume, decreased function, ischaemia, malnutrition, disease, or mutation. This condition is characterised by a partial or complete decrease in size and function of the breast tissue.
Also known as: Atrophy of breast | Hypoplasia of breast | hypoplastic breast | mammary hypoplasia
=== GRAPH WALKS ===
--- Walk 1 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--RELATED_TO--> [?] Structural developmental anomalies of liver
--- Walk 2 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--EXCLUDES--> [?] Unspecified jaundice
Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....
--- Walk 3 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Drug-induced or toxic liver disease
Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....
--- Walk 4 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Acute viral hepatitis
Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...
--- Walk 5 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--EXCLUDES--> [?] Fibropolycystic liver disease
--- Walk 6 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--CHILD--> [DB99.2] Hepatorenal syndrome
|
[
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --RELATED_TO--> [?] Structural developmental anomalies of liver",
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --EXCLUDES--> [?] Unspecified jaundice\n Def: A clinical manifestation of hyperbilirubinemia of unspecified origin, characterised by the yellowish staining of the skin; mucus membranes and sclera....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Drug-induced or toxic liver disease\n Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Acute viral hepatitis\n Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --EXCLUDES--> [?] Fibropolycystic liver disease",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --CHILD--> [DB99.2] Hepatorenal syndrome"
] |
DB9Z
|
Diseases of liver, unspecified
|
[
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K762",
"icd10_title": "Central hemorrhagic necrosis of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K70-K77",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K778",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K72",
"icd10_title": "Hepatic failure, not elsewhere classified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K76",
"icd10_title": "Other diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
}
] |
K7681
|
Hepatopulmonary syndrome
|
A 59-year-old male had undergone implantation of a cystoatrial shunt for treatment of an arachnoid cyst of the right frontal lobe in 1976; no revision of the implant was ever performed. In 2014, he underwent kidney transplantation for end stage polycystic kidney disease. After transplantation, the patient presented with recurrent urosepsis. In 2016, during a mild septic episode, a floating atrial thrombus associated to the VAS catheter tip was revealed by transoesophageal echocardiography (TEE). Cerebrospinal fluid (CSF) collected by direct puncture of the valve of the VAS was sterile, and biochemical and cellular parameters were normal. During 4 weeks of antibiotic and low molecular weight heparin treatment repeated examinations by (TEE) demonstrated a progressive reduction in the size of the thrombus until it completely disappeared. One month after suspension of antibiotic therapy, the patient was readmitted to the hospital with a new mild septic episode, a methycillin resistant S. aureus was isolated in the hemocultures, and an atrial thrombus associated with the catheter tip was again visible at TEE. Considering failure of conservative treatment, we decided to remove the atrial catheter , we exposed the VAS catheter at its entrance into the venous system distal to the valve at the neck, and after cutting the catheter, its proximal stump was connected to an external ventricular drainage (EVD), the intravascular portion of the catheter was anchored to the wall of the superior vena cava where pericatheter calcifications were demonstrated by CT scan and could not be removed by simple manual traction. Applying a refinement of the endoluminal dilation technique as pioneered by Hong the catheter was uneventfully removed . Briefly: we inserted a 4Fr valved sheath (Terumo) through the catheter exposed at the cervical level, then we advanced a 0.018 guidewire through the lumen of the catheter and navigated in the inferior vena cava, after performing several dilations of the catheter with a 6 diameter Sterling balloon catheter (Boston SC), leaving the guidewire in place, we again pulled on the atrial catheter that broke at the level of the calcifications. After removal of the segment of the catheter proximal to the calcifications, we captured from femoral approach with a 30-mm snare (Goose Neck, Bard) both the distal end of the guidewire and the distal segment of the catheter and completely removed it through a combined endovascular access through the internal jugular and femoral veins. After the procedure, the patient was progressively weaned from the EVD which was then closed 2 weeks after surgery and completely removed 5 days after closure of the EVD. The neurological examination of the patient remained normal and repeated CT scans did not show any relapse of the arachnoid cyst . Four years after VAS removal, the neurological condition of the patient remains stable without new septic episodes. Fig. 1 Atrial condition before VAS removal. a Preoperative thoracic axial CT scan with contrast at the level of the atrium showing the VAS catheter (arrow) in patient 1. b Preoperative coronal reconstruction of the trajectory of the VAS catheter in patient 1 in the internal jugular vein, superior vena cava and atrium, radiolucency of the catheter was increased by calcium deposition in the reactive tissue surrounding the catheter, the arrow indicates the presence of macroscopic calcifications around the catheter. c Preoperative thoracic axial CT scan with contrast at the level of the atrium showing the VAS catheter in patient 2. The arrow indicates a large atrial thrombus associated with the catheter. d Axial thoracic CT scan of patient 2, the arrow indicates the VA catheter inside the right atrium. e [ 18 F] fluoro-2-deoxy-d-glucose (FDG) PET scan image corresponding to thoracic CT scan in 1d, FDG accumulation (SUV 7.4) in close association with the position of the VAS-catheter (arrow) is visible. f Composite image demonstrating the colocalization of the FDG accumulation with the thrombus and reactive tissue surrounding the atrial catheter (arrow) Fig. 2 Removal of VAS catheter in patient 1. a Preoperative 3D CT scan reconstruction of the VAS catheter path from the valve to the right atrium, white asterisk (*) marks the site of macroscopic calcifications surrounding the catheter. b Fluoroscopy antero-posterior projection, the 0,018 inch guidewire is visible inside the VAS catheter, black asterisk (*) marks the site of the same macroscopic calcification shown in Fig. 1a . c Fluoroscopy antero-posterior projection, the VAS catheter was dilated by a 6 mm diameter Sterling balloon catheter. The calcification surrounding the VAS catheter partially restricts the dilation of the lumen compared to the adjacent segments (arrows), asterisk as in Fig. 1b . d Fluoroscopy antero-posterior projection, obtained after complete removal of the VAS catheter arrow points to an angiography catheter introduced after the VAS catheter was completely removed. e Picture of the distal portion of the VAS catheter immediately after extraction, the catheter is encrusted by calcified reactive tissue and partially deformed
| 4.042969
| 0.969727
|
sec[2]/sec[0]/p[0]
|
en
| 0.999997
|
33330950
|
https://doi.org/10.1007/s00701-020-04675-1
|
[
"catheter",
"atrial",
"scan",
"arrow",
"thrombus",
"calcifications",
"removal",
"atrium",
"completely",
"guidewire"
] |
[
{
"code": "QB62.Z",
"title": "Attention to artificial openings, unspecified"
},
{
"code": "QB30.5",
"title": "Fitting or adjustment of urinary device"
},
{
"code": "PK93.10",
"title": "Gastroenterology or urology devices associated with injury or harm, urinary catheter"
},
{
"code": "PK90.1",
"title": "Anaesthesiology devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices"
},
{
"code": "PK91.2Y",
"title": "Other specified cardiovascular devices associated with injury or harm, prosthetic or other implants, materials or accessory devices"
},
{
"code": "BC46&XA91S4",
"title": "Atrial thrombosis"
},
{
"code": "LA8Z",
"title": "Structural developmental anomaly of heart or great vessels, unspecified"
},
{
"code": "BC40.Z",
"title": "Acquired atrial abnormality, unspecified"
},
{
"code": "BC81.2Z",
"title": "Macro reentrant atrial tachycardia, unspecified"
},
{
"code": "LA8Y",
"title": "Other specified structural developmental anomaly of heart or great vessels"
}
] |
=== ICD-11 CODES FOUND ===
[QB62.Z] Attention to artificial openings, unspecified
Also known as: Attention to artificial openings, unspecified | Attention to artificial openings | toilet or cleansing of artificial opening | removal of catheter | passage of sounds or bougies
[QB30.5] Fitting or adjustment of urinary device
Also known as: Fitting or adjustment of urinary device | change of indwelling catheter | Removal of indwelling urinary catheter | removal of urinary catheter | removal of indwelling catheter
[PK93.10] Gastroenterology or urology devices associated with injury or harm, urinary catheter
Also known as: Gastroenterology or urology devices associated with injury or harm, urinary catheter | Gastroenterology or urology devices associated with adverse incidents, Foley catheter | Gastroenterology or urology devices associated with adverse incidents, indwelling urinary catheter | Mechanical complication of urinary catheter | Mechanical complication of urinary indwelling catheter
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
[PK90.1] Anaesthesiology devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices
Definition: An anaesthesiology device was involved in an adverse incident that occurred in a therapeutic (nonsurgical) and rehabilitative task
Also known as: Anaesthesiology devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices | Anaesthesiology devices associated with injury or harm, spinal catheter | Mechanical complication of spinal catheter | Anaesthesiology devices associated with injury or harm, epidural catheter | Anaesthesiology devices associated with injury or harm, endotracheal tube
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
[PK91.2Y] Other specified cardiovascular devices associated with injury or harm, prosthetic or other implants, materials or accessory devices
Also known as: Other specified cardiovascular devices associated with injury or harm, prosthetic or other implants, materials or accessory devices | Cardiovascular devices associated with injury or harm, conduits | Mechanical complication of other cardiac and vascular devices and implants | Mechanical complication of artificial heart | Mechanical complication of vascular balloon implant or device
[LA8Z] Structural developmental anomaly of heart or great vessels, unspecified
Also known as: Structural developmental anomaly of heart or great vessels, unspecified | Heart malformations | Cardiac malformations | congenital anomaly of heart | congenital heart disease
[BC40.Z] Acquired atrial abnormality, unspecified
Also known as: Acquired atrial abnormality, unspecified | Acquired atrial abnormality
[BC81.2Z] Macro reentrant atrial tachycardia, unspecified
Also known as: Macro reentrant atrial tachycardia, unspecified | Macro reentrant atrial tachycardia | MRAT - [macro re-entrant atrial tachycardia] | intra-atrial re-entry tachycardia | Atrial flutter NOS
[LA8Y] Other specified structural developmental anomaly of heart or great vessels
Also known as: Other specified structural developmental anomaly of heart or great vessels | Congenital anomaly of position or spatial relationships of thoraco-abdominal organs | Usual atrial arrangement | atrial situs solitus | Abnormal atrial arrangement
=== GRAPH WALKS ===
--- Walk 1 ---
[QB62.Z] Attention to artificial openings, unspecified
--PARENT--> [QB62] Attention to artificial openings
--EXCLUDES--> [?] Tracheostomy malfunction
--- Walk 2 ---
[QB62.Z] Attention to artificial openings, unspecified
--PARENT--> [QB62] Attention to artificial openings
--CHILD--> [QB62.2] Attention to ileostomy
--- Walk 3 ---
[QB30.5] Fitting or adjustment of urinary device
--PARENT--> [QB30] Adjustment or management of implanted devices
--PARENT--> [?] Fitting, adjustment or management of devices
--- Walk 4 ---
[QB30.5] Fitting or adjustment of urinary device
--PARENT--> [QB30] Adjustment or management of implanted devices
--CHILD--> [QB30.2] Adjustment or management of cardiac devices
--- Walk 5 ---
[PK93.10] Gastroenterology or urology devices associated with injury or harm, urinary catheter
--EXCLUDES--> [?] Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
--EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical device, implant or graft
--- Walk 6 ---
[PK93.10] Gastroenterology or urology devices associated with injury or harm, urinary catheter
--EXCLUDES--> [?] Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
--EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical device, implant or graft
|
[
"[QB62.Z] Attention to artificial openings, unspecified\n --PARENT--> [QB62] Attention to artificial openings\n --EXCLUDES--> [?] Tracheostomy malfunction",
"[QB62.Z] Attention to artificial openings, unspecified\n --PARENT--> [QB62] Attention to artificial openings\n --CHILD--> [QB62.2] Attention to ileostomy",
"[QB30.5] Fitting or adjustment of urinary device\n --PARENT--> [QB30] Adjustment or management of implanted devices\n --PARENT--> [?] Fitting, adjustment or management of devices",
"[QB30.5] Fitting or adjustment of urinary device\n --PARENT--> [QB30] Adjustment or management of implanted devices\n --CHILD--> [QB30.2] Adjustment or management of cardiac devices",
"[PK93.10] Gastroenterology or urology devices associated with injury or harm, urinary catheter\n --EXCLUDES--> [?] Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm\n --EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical device, implant or graft",
"[PK93.10] Gastroenterology or urology devices associated with injury or harm, urinary catheter\n --EXCLUDES--> [?] Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm\n --EXCLUDES--> [?] Mode of injury or harm associated with a surgical or other medical device, implant or graft"
] |
QB62.Z
|
Attention to artificial openings, unspecified
|
[
{
"from_icd11": "QB62.Z",
"icd10_code": "Z436",
"icd10_title": "Encounter for attention to other artificial openings of urinary tract"
},
{
"from_icd11": "QB62.Z",
"icd10_code": "Z434",
"icd10_title": "Encounter for attention to other artificial openings of digestive tract"
},
{
"from_icd11": "QB62.Z",
"icd10_code": "Z438",
"icd10_title": "Encounter for attention to other artificial openings"
},
{
"from_icd11": "QB62.Z",
"icd10_code": "Z439",
"icd10_title": "Encounter for attention to unspecified artificial opening"
},
{
"from_icd11": "QB62.Z",
"icd10_code": "Z43",
"icd10_title": "Encounter for attention to artificial openings"
},
{
"from_icd11": "QB30.5",
"icd10_code": "Z466",
"icd10_title": "Encounter for fitting and adjustment of urinary device"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83022A",
"icd10_title": "Displacement of nephrostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83020A",
"icd10_title": "Displacement of cystostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83032A",
"icd10_title": "Leakage of nephrostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83092A",
"icd10_title": "Other mechanical complication of nephrostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83021A",
"icd10_title": "Displacement of indwelling urethral catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83028A",
"icd10_title": "Displacement of other urinary catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83090A",
"icd10_title": "Other mechanical complication of cystostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83012A",
"icd10_title": "Breakdown (mechanical) of nephrostomy catheter, initial encounter"
},
{
"from_icd11": "PK93.10",
"icd10_code": "T83030A",
"icd10_title": "Leakage of cystostomy catheter, initial encounter"
}
] |
Z436
|
Encounter for attention to other artificial openings of urinary tract
|
A 69 years-old woman, with a history of papillary thyroid carcinoma, type 2 diabetes mellitus (T2DM) treated with metformin, and hypertension on treatment with angiotensin II receptor blockers (ARB), calcium antagonists, and β-blockers, was diagnosed in October 2015 as having a right-sided AI during a routine abdominal ultrasound exam. A contrast-enhanced computed tomography (CT) scan of the abdomen showed a homogeneous right adrenal mass of 32 × 40 mm with density of 35 HU and relative contrast washout of 21% . Basal plasma cortisol, ACTH, and overnight 1 mg dexamethasone suppression test (DST) were normal. Similarly, 24 h urine cortisol, catecholamine, dopamine, and plasma vanilmandelic acid concentrations were within normal ranges. Plasma renin activity and aldosterone levels were not measured because of the concomitant therapy with ARB. The AI was then labeled as a non-functional benign adrenal adenoma. Clinical and biochemical characteristics were recorded yearly during the follow-up and shown in Table 1 . The non-contrast CT-scan performed after 8 months from the diagnosis confirmed the substantial dimensional stability of the adrenal mass . Given the indeterminate radiological features of the lesion, the same exam was repeated in October 2017, showing a slight dimensional growth of the nodule (32 × 44 mm) and change in its density (39 HU) . Nevertheless, the patient was normotensive (110/80 mmHg) and T2DM was well controlled (HbA1c 51 mmol/mol), without clear signs or symptoms of adrenal hormones excess. In January 2018, the patient reported worsening of diabetes [average fasting plasma glucose (FPG): 185 mg/dL] and hypertension [mean blood pressure (BP) 150/95 mmHg] despite no treatment modification. For this reason, in May 2018 she was referred to our department for further investigations. On admission, she was completely asymptomatic, with a BP of 160/90 mmHg, a heart rate of 76 bpm, and FPG of 167 mg/dL. Her recent history was unremarkable, with no relevant signs or symptoms reported. During the second day of evaluation, she complained of palpitations, chest pain, diaphoresis, and profound asthenia. On examination, blood pressure and heart rate were high (210/115 mmHg; 115 bpm), while there was evidence of marked hyperglycemia (300 mg/dl) at the capillary blood glucose monitoring. Suspecting an acute coronary syndrome (ACS), she was sent to the emergency department, where the electrocardiogram (EKG) performed showed a diffuse ST elevation, with ST-depression in leads aVR and V1. The initial laboratory work-up showed: CK-MB 58.13 μg/L (normal <2.88), high-sensitivity Troponin I 1754 ng/L (normal <14), BNP 2623 pg/mL (normal <100), corroborating the diagnosis of acute myocardial infarction. Therefore, she underwent cardiac catheterization, revealing the absence of obstructing coronary artery disease. However, ventriculography showed left ventricular apical akinesia, basal hyperkinesia, and depressed systolic function, with an ejection fraction (LVEF) of 35% . Based on these findings, she was diagnosed as having TTS. In the following days, she developed type 1 respiratory failure, so she was admitted to the intensive care unit and treated with non-invasive ventilation. Intravenous urapidil, esmolol, and subcutaneous insulin were started for hypertension, tachycardia, and hyperglycemia, respectively, with a complete recovery after 72 h. Thus, she was transferred to our department for further investigations. Considering the patient's clinical history, a pheochromocytoma was suspected. A 24 h urine collection was performed and revealed high metanephrine and normetanephrine levels. A contrast-enhanced abdominal MRI was ordered, which displayed a right adrenal mass measuring 50 × 53 mm, with hyperintense T2-weighted images and a decrease in signal intensity of 12% . The patient was managed with doxazosin, atenolol, and massive hydration for 1 week, then she underwent laparoscopic right adrenalectomy, which was performed without any complication. Following the surgical procedure, all symptoms resolved. Blood pressure remained stable off all medications and glycemia was well-controlled with metformin. The histological examination showed a tumoral mass positive for chromogranin and synaptophysin immunostaining, with a Ki-67 index <1% and a PASS score of 7. Morphological and immunophenotypical findings were consistent with a diagnosis of pheochromocytoma . How suggested by international guidelines, several genes associated with pheochromocytoma were sequenced (SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, MAX, TMEM127, RET, EPAS1, FH, EGLN1, and KIF1Bβ), without any evidence of pathogenic mutations. The post-operative 24 h urine metanephrine levels were within normal reference values (metanephrine 20.9 μg/24 h; normetanephrine 268.3 μg/24 h) and BNP progressively returned to the normal value (210 pg/mL). She was discharged from hospital on 5th post-operative day, on therapy with aspirin and ace-inhibitor. We couldn't prescribe β-blocker because of the prolonged QTc at EKG. After 12 months of follow-up, the patient remained asymptomatic, with no echocardiographic or EKG stigmata of TTS.
| 4.058594
| 0.976074
|
sec[1]/p[0]
|
en
| 0.999996
|
32117073
|
https://doi.org/10.3389/fendo.2020.00051
|
[
"adrenal",
"contrast",
"plasma",
"mmhg",
"blood",
"hypertension",
"urine",
"without",
"pressure",
"department"
] |
[
{
"code": "5A76.Y",
"title": "Other specified disorders of adrenal gland"
},
{
"code": "5A7Z",
"title": "Disorders of the adrenal glands or adrenal hormone system, unspecified"
},
{
"code": "5A74.Z",
"title": "Adrenocortical insufficiency, unspecified"
},
{
"code": "5A74.Y",
"title": "Other specified adrenocortical insufficiency"
},
{
"code": "LC8Z",
"title": "Structural developmental anomalies of the adrenal glands, unspecified"
},
{
"code": "9D43",
"title": "Impairment of contrast vision"
},
{
"code": "QA00.6Y",
"title": "Other specified examination of eyes or vision"
},
{
"code": "NE60",
"title": "Harmful effects of drugs, medicaments or biological substances, not elsewhere classified"
},
{
"code": "PB28",
"title": "Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance"
},
{
"code": "PC98",
"title": "Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance"
}
] |
=== ICD-11 CODES FOUND ===
[5A76.Y] Other specified disorders of adrenal gland
Also known as: Other specified disorders of adrenal gland | Suprarenal gland abscess | Suprarenal abscess | Adrenal gland inflammation | adrenal glandular inflammation
[5A7Z] Disorders of the adrenal glands or adrenal hormone system, unspecified
Also known as: Disorders of the adrenal glands or adrenal hormone system, unspecified | Adrenal gland disease, not elsewhere classified | adrenal cortex disease | adrenal cortical disease | adrenal glandular disease
[5A74.Z] Adrenocortical insufficiency, unspecified
Also known as: Adrenocortical insufficiency, unspecified | Adrenocortical insufficiency | adrenal failure NOS | Hypoadrenocorticism | adrenocortical hypofunction
[5A74.Y] Other specified adrenocortical insufficiency
Also known as: Other specified adrenocortical insufficiency | Congenital adrenocortical insufficiency | Congenital isolated ACTH deficiency | Familial adrenal hypoplasia | Familial hypoadrenocorticism
[LC8Z] Structural developmental anomalies of the adrenal glands, unspecified
Also known as: Structural developmental anomalies of the adrenal glands, unspecified | adrenal anomaly | adrenal gland anomaly | congenital anomaly of adrenal gland | congenital malformation of adrenal gland
[9D43] Impairment of contrast vision
Definition: Contrast sensitivity refers to the ability to distinguish small differences in brightness between adjacent surfaces.
Peak Contrast sensitivity refers to the smallest differences that are discernible for large stimuli.
For smaller objects, such as those involved in many Activities of Daily Living, contrast sensitivity interacts with visual acuity and visual field. Better contrast makes smaller details visible. The visual field is larger for stronger stimuli.
Also known as: Impairment of contrast vision | Moderate impairment of contrast vision | Profound impairment of contrast vision
[QA00.6Y] Other specified examination of eyes or vision
Also known as: Other specified examination of eyes or vision | No Impairment of Contrast vision | Normal colour vision | No Impairment of Dark adaptation | No diplopia
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
Also known as: Harmful effects of drugs, medicaments or biological substances, not elsewhere classified | drugs, medicaments or biological substances, toxicity not elsewhere classified | adverse drug effects | drug reaction NOS | drug allergy NOS
Excludes: Alcohol intoxication | pathological drug intoxication | hypersensitivity reaction to correctly administered drug
[PB28] Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance
Also known as: Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance | accidental overdose of other or unspecified drug, medicament or biological substance | accidental poisoning by other or unspecified drug, medicament or biological substance | other or unspecified drug, medicament or biological substance taken in error | accidental drug overdose
[PC98] Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance
Also known as: Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance | Intentional self-poisoning by and exposure to other or unspecified drug, medicament or biological substance | Intentional overdose of other or unspecified drug, medicament or biological substance | self-administered overdose by drugs | Intentional self-harm by exposure to or harmful effects of systemic antibiotics
=== GRAPH WALKS ===
--- Walk 1 ---
[5A76.Y] Other specified disorders of adrenal gland
--PARENT--> [5A76] Certain specified disorders of adrenal gland
--CHILD--> [5A76.Y] Other specified disorders of adrenal gland
--- Walk 2 ---
[5A76.Y] Other specified disorders of adrenal gland
--PARENT--> [5A76] Certain specified disorders of adrenal gland
--CHILD--> [5A76.Y] Other specified disorders of adrenal gland
--- Walk 3 ---
[5A7Z] Disorders of the adrenal glands or adrenal hormone system, unspecified
--PARENT--> [?] Disorders of the adrenal glands or adrenal hormone system
--CHILD--> [5A70] Cushing syndrome
Def: Cushing syndrome results from excess of corticosteroid hormones in the body due to overstimulation of the adrenal glands by excessive amounts of the hormone ACTH, secreted either by a tumuor of the pi...
--- Walk 4 ---
[5A7Z] Disorders of the adrenal glands or adrenal hormone system, unspecified
--PARENT--> [?] Disorders of the adrenal glands or adrenal hormone system
--RELATED_TO--> [?] Gonadotropin deficiency
Def: Deficiency of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) resulting in hypogonadism (male and female). Includes deficiency of Gonadotropin Releasing Hormone (GnRH, LHRH)....
--- Walk 5 ---
[5A74.Z] Adrenocortical insufficiency, unspecified
--PARENT--> [5A74] Adrenocortical insufficiency
Def: A condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol. It may also include impaired production of aldosterone (a mineralocorticoid), which reg...
--CHILD--> [5A74.0] Acquired adrenocortical insufficiency
Def: This is a acquired condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol; but may also include impaired production of aldosterone (a mineralocor...
--- Walk 6 ---
[5A74.Z] Adrenocortical insufficiency, unspecified
--PARENT--> [5A74] Adrenocortical insufficiency
Def: A condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol. It may also include impaired production of aldosterone (a mineralocorticoid), which reg...
--RELATED_TO--> [?] Neonatal haemorrhage originating in adrenal gland
Def: A condition characterised by bleeding into the adrenal glands in a newborn....
|
[
"[5A76.Y] Other specified disorders of adrenal gland\n --PARENT--> [5A76] Certain specified disorders of adrenal gland\n --CHILD--> [5A76.Y] Other specified disorders of adrenal gland",
"[5A76.Y] Other specified disorders of adrenal gland\n --PARENT--> [5A76] Certain specified disorders of adrenal gland\n --CHILD--> [5A76.Y] Other specified disorders of adrenal gland",
"[5A7Z] Disorders of the adrenal glands or adrenal hormone system, unspecified\n --PARENT--> [?] Disorders of the adrenal glands or adrenal hormone system\n --CHILD--> [5A70] Cushing syndrome\n Def: Cushing syndrome results from excess of corticosteroid hormones in the body due to overstimulation of the adrenal glands by excessive amounts of the hormone ACTH, secreted either by a tumuor of the pi...",
"[5A7Z] Disorders of the adrenal glands or adrenal hormone system, unspecified\n --PARENT--> [?] Disorders of the adrenal glands or adrenal hormone system\n --RELATED_TO--> [?] Gonadotropin deficiency\n Def: Deficiency of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) resulting in hypogonadism (male and female). Includes deficiency of Gonadotropin Releasing Hormone (GnRH, LHRH)....",
"[5A74.Z] Adrenocortical insufficiency, unspecified\n --PARENT--> [5A74] Adrenocortical insufficiency\n Def: A condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol. It may also include impaired production of aldosterone (a mineralocorticoid), which reg...\n --CHILD--> [5A74.0] Acquired adrenocortical insufficiency\n Def: This is a acquired condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol; but may also include impaired production of aldosterone (a mineralocor...",
"[5A74.Z] Adrenocortical insufficiency, unspecified\n --PARENT--> [5A74] Adrenocortical insufficiency\n Def: A condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol. It may also include impaired production of aldosterone (a mineralocorticoid), which reg...\n --RELATED_TO--> [?] Neonatal haemorrhage originating in adrenal gland\n Def: A condition characterised by bleeding into the adrenal glands in a newborn...."
] |
5A76.Y
|
Other specified disorders of adrenal gland
|
[
{
"from_icd11": "5A7Z",
"icd10_code": "E2740",
"icd10_title": "Unspecified adrenocortical insufficiency"
},
{
"from_icd11": "5A7Z",
"icd10_code": "E2749",
"icd10_title": "Other adrenocortical insufficiency"
},
{
"from_icd11": "5A7Z",
"icd10_code": "E279",
"icd10_title": "Disorder of adrenal gland, unspecified"
},
{
"from_icd11": "5A7Z",
"icd10_code": "E27",
"icd10_title": "Other disorders of adrenal gland"
},
{
"from_icd11": "5A7Z",
"icd10_code": "E274",
"icd10_title": "Other and unspecified adrenocortical insufficiency"
},
{
"from_icd11": "LC8Z",
"icd10_code": "Q891",
"icd10_title": "Congenital malformations of adrenal gland"
},
{
"from_icd11": "9D43",
"icd10_code": "H538",
"icd10_title": "Other visual disturbances"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95A",
"icd10_title": "Adverse effect of other bacterial vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z15A",
"icd10_title": "Adverse effect of immunoglobulin, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z95A",
"icd10_title": "Adverse effect of other vaccines and biological substances, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95S",
"icd10_title": "Adverse effect of other bacterial vaccines, sequela"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B95A",
"icd10_title": "Adverse effect of other viral vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A25A",
"icd10_title": "Adverse effect of mixed bacterial vaccines without a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A91A",
"icd10_title": "Poisoning by other bacterial vaccines, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T498X5A",
"icd10_title": "Adverse effect of other topical agents, initial encounter"
}
] |
E2740
|
Unspecified adrenocortical insufficiency
|
A 34-year-old female visited our hospital in July 2016 because of a 4-month history of intermittent epigastralgia and poor appetite. The symptoms were not associated with food intake or daily exercise, and there was no relieving or aggravating factor. After admission, body check showed no swelling of the salivary glands and the cervical lymph nodes were not palpable. Her laboratory tests revealed elevated liver enzymes, including glutamate pyruvate transaminase (ALT) of 449 IU/L (reference range, 9–60 IU/L), glutamate oxaloacetate transaminase (AST) of 383 IU/L (reference range, 15–45 IU/L), gamma Glutamyl transpeptidase (GGT) of 823 IU/L (reference range, 10–60 IU/L, alkaline hosphate (ALP) of 1170 IU/L (reference range, 35–100 IU/L), total bilirubin (Tbil) of 183 μmol/L (reference range, 1.7–21 mg/dL), conjugated bilirubin (Dbil) of 142.1 μmol/L (reference range, 0.0–6.8 μmol/L), and unconjugated bilirubin (Ibil) of 40.9 μmol/L (reference range, 1.7–14.2 μmol/L). The results of other laboratory tests, including cholesterol profile, electrolytes, a complete blood count/differential count, renal function parameters and most tumor markers were within the normal range except high elevation of CA50, CA19–9, CA242, TPS and TPA (Table 1 ). Esophagogastroduodenoscopy revealed enlargement of duodenal papilla and external compression of the duodenum, which raised suspicion for a pancreatic tumor. Abdominal ultrasonography showed a mass in the uncinate process of the pancreas. Abdominal computed tomography (CT) with contrast enhancement revealed a mass arising in the end of dilated lower bile duct. Abdominal MRI depicted dilatation of the intrahepatic, extrahepatic bile ducts and main pancreatic duct caused by 5.5-cm mass lesion in the pancreatic head, with encasement of superior mesenteric vein. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT was performed and showed an FDG-avid, hypermetabolic, swollen soft tissue mass in the pancreatic head with a maximum standardized uptake value of 8.3. Adjacent low-grade FDG-avid lymph nodes with a maximum standardized uptake value of 3.0 were also noted. No FDG-avid lesions were present in the bilateral salivary glands, retroperitoneal spaces, orbiliary tracts . In all, these findings were highly suggestive of obstructive jaundice due to a malignant pancreatic tumor with no distant metastasis. As the patient refuse to take US-guided biopsy and PC was highly suspected, the patient underwent pancreaticoduodenectomy and recover well. However, postoperative histologic analysis of the pancreatic head revealed moderate lymphoplasmacytic infiltration with obliterative venulitis and stromal fibrosis. Immunohistochemically, abundant IgG4-positive plasma cells (> 20/hpf and IgG4+/IgG+ plasma cell ratio > 40%) were observed infiltrating the head of the pancreas, consistent with AIP . Further examination showed all the serum immune antibody including IgG4 were within normal range except slightly elevation of IgM and AMA (Table 2 ). Table 1 Changes of tumor markers in two cases Case 1 Case 2 Reference time 27 days 31 days 37 days 3 days 15 days 64 days CEA 1.46 0.84 0.75 1.5 0.80 0.15 <3 μ g/L CA199 426.50↑ 227.89↑ 282.22↑ 1.1 2.05 0.55 <20 U/mL CA242 43.34↑ 40.92↑ 1.03 1.65 <12 U/mL AFP 2.92 4.35 4.16 6.0 5.17 6.15 <15 μ g/L CA724 4.25 1.55 0.82 0.66 <10 U/mL CA50 222.70↑ 32.44 51.52 13.55 <20 U/mL SCC 0.24 0.27 0.19 <1 ng/mL TPA 5.25↑ 9.28↑ 14.63↑ <2 ng/mL TPS 234.57↑ 765.82↑ 1010.07↑ <150 U/L VEGF 300.00 257.66 617.26 62–707 pg/mL CA125 28 5.75 <35 U/mL CA153 7.5 <31.3 U/mL Table 2 Serological immune realted antibody: ↑ represent higher than reference, ↓ represent lower than reference. Immunoturbidimetry (ITM), Western blotting (WB), indirect immunofluorescence (IFL), blank no test Case 1 (postoperative) Case 2 Reference (unit) method preoperative postoperative IgA 1.66 2.14 2.23 0.7–4.0 g/L Elisa IgG 13.34 11.34 16.3 7–16 g/L Elisa IgM 3.25↑ 0.67 0.909 0.4–2.3 g/L Elisa IgE 657.50↑ 20~200 IU/mL Elisa t-PSA 0.831 0–4 ng/mL Elisa f-PSA 0.301 0–4 ng/mL Elisa ASO < 25.0 0–116 IU/mL Elisa Anti-CCP 1.75 0–25 IU/mL Elisa anti-TB negative negative Elisa AMA-M2 8.12 0–25 IU/mL Elisa Anti-a-Fodrin negative negative Elisa Complement 3 1.09 0.740↓ 0.79–1.52 g/L ITM Complement 4 0.14 0.069↓ 0.1–0.4 g/L ITM RF 1.95 73.1↑ <20 IU/mL ITM IgG1 1170.0↑ 405–1011 mg/dL ITM IgG2 234 169–768 mg/dL ITM IgG3 32.8 11–85 mg/dL ITM IgG4 5.43 98 266.0↑ <201 mg/dL ITM ANA negative negative negative IFL AKA negative negative IFL ASMA negative negative IFL AMA 1:100 ↑ negative IFL AMA-M2 negative negative negative WB Sp100 negative negative negative WB LKM1 negative negative negative WB Gp210 negative negative negative WB LC1 negative negative negative WB SLA negative negative negative WB Anti-Nucleosomes negative negative WB Anti-dsDNA negative negative WB SmD1 negative negative WB Anti-PO negative negative WB Anti-Histones negative negative WB U1-SnRNP negative negative WB Anti-SSA/Ro60 negative negative WB Anti-SSA/Ro52 negative negative WB SSB/La negative negative WB Anti-Slc-70 negative negative WB Anti-CENP-B negative negative WB Anti-Jo-1 negative negative WB
| 4.058594
| 0.963867
|
sec[2]/sec[0]/p[0]
|
en
| 0.999997
|
31699117
|
https://doi.org/10.1186/s13023-019-1217-z
|
[
"anti",
"reference",
"elisa",
"range",
"pancreatic",
"tumor",
"head",
"including",
"bilirubin",
"abdominal"
] |
[
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MB23.1",
"title": "Antisocial behaviour"
},
{
"code": "3B4Z",
"title": "Coagulation defects, unspecified"
},
{
"code": "4A45.Z",
"title": "Antiphospholipid syndrome, unspecified"
},
{
"code": "4A43.Y",
"title": "Other specified overlap non-organ specific systemic autoimmune disease"
},
{
"code": "6B22.Z",
"title": "Olfactory reference disorder, unspecified"
},
{
"code": "MB26.03",
"title": "Delusion of reference"
},
{
"code": "6B22.1",
"title": "Olfactory reference disorder with poor to absent insight"
},
{
"code": "4B00.0Z",
"title": "Neutropaenia, unspecified"
},
{
"code": "3B63.1Z",
"title": "Acquired thrombocytosis, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MB23.1] Antisocial behaviour
Definition: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated.
Also known as: Antisocial behaviour | Child or adolescent antisocial behaviour
[3B4Z] Coagulation defects, unspecified
Also known as: Coagulation defects, unspecified | blood clotting disturbance | blood clotting defect | blood clotting factor deficiency | clotting abnormality
[4A45.Z] Antiphospholipid syndrome, unspecified
Also known as: Antiphospholipid syndrome, unspecified | Antiphospholipid syndrome | Hughes syndrome | Anticardiolipin syndrome
[4A43.Y] Other specified overlap non-organ specific systemic autoimmune disease
Also known as: Other specified overlap non-organ specific systemic autoimmune disease | Antisynthetase syndrome | Reynolds syndrome | Syndromic multisystem autoimmune disease due to ITCH deficiency | Eosinophilia myalgia syndrome
[6B22.Z] Olfactory reference disorder, unspecified
Also known as: Olfactory reference disorder, unspecified | Olfactory reference disorder | Delusions of malodour
[MB26.03] Delusion of reference
Definition: A delusion that events, objects, or other people in the person's immediate environment have a particular and unusual personal significance, usually of a negative or pejorative nature.
Also known as: Delusion of reference
[6B22.1] Olfactory reference disorder with poor to absent insight
Definition: All definitional requirements of olfactory reference disorder are met. Most or all of the time, the individual is convinced that the disorder-specific beliefs are true and cannot accept an alternative explanation for their experience. The lack of insight exhibited by the individual does not vary markedly as a function of anxiety level.
Also known as: Olfactory reference disorder with poor to absent insight
[4B00.0Z] Neutropaenia, unspecified
Also known as: Neutropaenia, unspecified | Neutropenia | Disorders with decreased neutrophil counts | neutropaenic disorder | neutrophil count below reference range
[3B63.1Z] Acquired thrombocytosis, unspecified
Also known as: Acquired thrombocytosis, unspecified | Acquired thrombocytosis | Idiopathic haemorrhagic thrombocythaemia | Essential thrombocythaemia | primary haemorrhagic thrombocythaemia
=== GRAPH WALKS ===
--- Walk 1 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--EXCLUDES--> [?] Labour or delivery complicated by fetal distress
--- Walk 2 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--EXCLUDES--> [?] Labour or delivery complicated by fetal distress
--- Walk 3 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--- Walk 4 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--RELATED_TO--> [?] Speech dysfluency
Def: Speech dysfluency is characterised by the frequent or pervasive disruption of the rhythmic flow of speech that arises subsequent to the developmental period (i.e., adult onset) and is outside the limi...
--- Walk 5 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--PARENT--> [?] Coagulation defects, purpura or other haemorrhagic or related conditions
Def: A condition caused by determinants arising during the antenatal period, after birth or by genetically inherited factors, leading to coagulation defects. This condition is characterised by increased br...
--- Walk 6 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--CHILD--> [3B4Z] Coagulation defects, unspecified
|
[
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --EXCLUDES--> [?] Labour or delivery complicated by fetal distress",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --EXCLUDES--> [?] Labour or delivery complicated by fetal distress",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --RELATED_TO--> [?] Speech dysfluency\n Def: Speech dysfluency is characterised by the frequent or pervasive disruption of the rhythmic flow of speech that arises subsequent to the developmental period (i.e., adult onset) and is outside the limi...",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --PARENT--> [?] Coagulation defects, purpura or other haemorrhagic or related conditions\n Def: A condition caused by determinants arising during the antenatal period, after birth or by genetically inherited factors, leading to coagulation defects. This condition is characterised by increased br...",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --CHILD--> [3B4Z] Coagulation defects, unspecified"
] |
JA86.Y
|
Maternal care for other specified fetal problems
|
[
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D688",
"icd10_title": "Other specified coagulation defects"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D689",
"icd10_title": "Coagulation defect, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D699",
"icd10_title": "Hemorrhagic condition, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D698",
"icd10_title": "Other specified hemorrhagic conditions"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D65-D69",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D69",
"icd10_title": "Purpura and other hemorrhagic conditions"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6861",
"icd10_title": "Antiphospholipid syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6869",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6862",
"icd10_title": "Lupus anticoagulant syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D686",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "6B22.Z",
"icd10_code": "F428",
"icd10_title": "Other obsessive-compulsive disorder"
}
] |
O26841
| |
A 28 year-old nulliparous woman, previously diagnosed for HWWS, was referred to San Camillo-Forlanini Hospital during her third spontaneous pregnancy. The clinical history of our patient began when at her birth, the ectrodactyly of the right foot (absence of the 2 medial rays), immediately became apparent. The karyotype analysis was normal 46 XX. At age 1, she underwent a surgical correction of this anomaly with consequent partial improvement of a functional deficiency. An upper abdominal ultrasound, performed after a history of recurrent urinary tract infections and pyelonephritis, revealed the absence of the left kidney and the right megaureter. At 12 years, after 2 months from menarche, due to severe acute pelvic pain, a pelvic ultrasound and a magnetic resonance imaging (MRI) were performed. MRI showed a left blind hemivagina with hematocolpos, uterus didelphys with hematometra in the left hemiuterus and ipsilateral hematosalpinx. These imaging findings were later confirmed by the diagnostic laparoscopy which showed normal right uterus, right fallopian tube and both regular ovaries. Consequently, she underwent a surgical reconstruction of the vagina consisting in the drainage of hematocolpos and the removal of the vaginal septum, whereas an abdominal left hemi- hysterectomy and ipsilateral salpingectomy were performed through a Pfannenstiel incision. Her obstetric history was significant for two spontaneous abortion at the age of 26, occurred at 7th and 12th weeks respectively. She had no problem of fertility in anamnesis. The woman came to our observation for the first time at 15 weeks of pregnancy for abortion threats resolved with vaginal progesterone. Singleton fetus was anatomically in the norm. The patient had a moderate protenuria of 1400 mg in 24 hours, so she started a proper diet and a monitor of urine proteins. Close and regular surveillance (clinical, laboratory, and ultrasound) was initiated. The obstetric ultrasound controls revealed adequate growth of a fetus without major malformations, and normal Doppler indices of the fetal, feto-maternal and utero-placental vessels. During the three trimesters, frequent urinary infections occurred that were appropriately treated after urine culture and antibiogram test. At 33 weeks + 5 days of gestational age she was admitted to our hospital for premature spontaneous rupture of membranes (pPROM): she reported light amniotic fluid leak one hour before our observation. The admission assessment detected a reduced amniotic fluid index, a regular fetal growth and posterior placenta in the norm; the umbilical artery Doppler values were in the range, the fetal cardiac monitoring was regular and uterine contractions were present. The vaginal examination revealed a soft cervix, 80% effaced, dilated about 2 cm, and the fetus was in breech at station -3. The ultrasound cervical length was 24 mm. A single course of antenatal corticosteroid therapy for fetal lungs maturity induction and tocolytic drugs were administered. On the second day of hospitalization, an emergency caesarean section was performed because the cervix was modified (dilatation about 4 cm), uterine contractility increased while persisting breech presentation . A female infant was born weighing 2278 gr, with Apgar scores 8/9/9 at 1, 5, and 10 minutes respectively; the umbilical artery ph was 7.35. The placenta weighed 380 grams. The mother and the newborn, made an uncomplicated post-surgical/postnatal course and were discharged on day 3 and 15 respectively. Seventeen days after caesarean section, the woman came back again to our institution for a complaint of asthenia and fever ( > 38°C), resistant to paracetamol for five days. On physical examination, she had abdominal tenderness in the lower quadrants and physiological vaginal lochia. Blood exams showed increased leukocyte and inflammatory markers: white blood cells (WBC) were 14,2 x 10 3 /ml (range 4,0-10,0 x 10 3 /ml); C-reactive protein (CRP) was 19.98 mg/l (range 0,01-1 mg/dl) and procalcitonin was 0.22 ng/ml (negative: <0,05 ng/ml). The pelvic ultrasound and the computerized tomography (CT) demonstrated a pelvic abscess neighboring to the lower anterior wall of the uterus with dimensions of 53 x 47 mm . The treatment started immediately and consisted in intravenous antibiotic therapy with Meropenem 500 mg three times a day and low- molecular weight heparin (LMWH), Enoxaparin 4000 UI subcutaneous daily. Six days after the hospital admission with the right therapy, the inflammatory indices reduced: WBC were 9,8 x 10 3 /ml, PCR was 4.37 mg/l and procalcitonin was 0.12 ng/ml. After discharge, we started a follow-up to assess the clinical conditions of our patient: she was asymptomatic, her blood exams were within normal ranges and the pelvic abscess was significantly decreased. Histopathologic examination of the placenta and umbilical cord obtained after about 40 days, not identified signs of chorioamnionitis and/or funisitis. Fig. 1 Uterus at the time of caesarean delivery Fig. 2 Pelvic Abscess at the ultrasound imaging. Abscess neighboring to the lower anterior wall of the uterus with dimensions of 53 x 47 mm
| 3.994141
| 0.979492
|
sec[1]/p[0]
|
en
| 0.999997
|
30558561
|
https://doi.org/10.1186/s12884-018-2133-2
|
[
"ultrasound",
"pelvic",
"uterus",
"regular",
"vaginal",
"fetal",
"abscess",
"spontaneous",
"abdominal",
"imaging"
] |
[
{
"code": "JB07.Z",
"title": "Labour or delivery complicated by fetal distress, unspecified"
},
{
"code": "NE8Y",
"title": "Other specified injury or harm arising from surgical or medical care, not elsewhere classified"
},
{
"code": "JA66.3",
"title": "Abnormal ultrasonic finding on antenatal screening of mother"
},
{
"code": "PK9A.1",
"title": "Physical medicine devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices"
},
{
"code": "QA45.Y",
"title": "Other specified antenatal screening"
},
{
"code": "FC00.3",
"title": "Acquired deformity of pelvis"
},
{
"code": "GA34.Y",
"title": "Other specified female pelvic pain associated with genital organs or menstrual cycle"
},
{
"code": "LB30.7",
"title": "Ectopic or pelvic kidney"
},
{
"code": "MD82",
"title": "Intra-abdominal or pelvic swelling, mass or lump"
},
{
"code": "GA05.Z",
"title": "Female pelvic inflammatory diseases, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
Also known as: Labour or delivery complicated by fetal distress, unspecified | Labour or delivery complicated by fetal distress | Labour and delivery complicated by fetal stress | fetal distress affecting labour and delivery | Electrocardiographic evidence of fetal distress
[NE8Y] Other specified injury or harm arising from surgical or medical care, not elsewhere classified
Also known as: Other specified injury or harm arising from surgical or medical care, not elsewhere classified | Other injury or harm from surgical or medical care, not elsewhere classified | Complication of ultrasound therapy | Sequelae of complications of surgical and medical care, not elsewhere classified
[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother
Definition: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother.
Also known as: Abnormal ultrasonic finding on antenatal screening of mother | antenatal ultrasound scan abnormal
[PK9A.1] Physical medicine devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices
Definition: A physical medicine device was involved in an adverse incident that occurred in a therapeutic (nonsurgical) and rehabilitative task
Also known as: Physical medicine devices associated with injury or harm, therapeutic, nonsurgical or rehabilitative devices | Physical medicine devices associated with adverse incidents, therapeutic ultrasound | Physical medicine devices associated with adverse incidents, chilling or heating units | Physical medicine devices associated with adverse incidents, exercise equipment | Physical medicine devices associated with adverse incidents, massagers
[QA45.Y] Other specified antenatal screening
Also known as: Other specified antenatal screening | Other antenatal screening based on amniocentesis | antenatal screening using amniocentesis | Antenatal screening for malformations using ultrasound or other physical methods | Antenatal screening for fetal growth retardation using ultrasound or other physical methods
[FC00.3] Acquired deformity of pelvis
Also known as: Acquired deformity of pelvis | deformity of pelvis | pelvic deformity | ischium deformity | ilium deformity
Excludes: Maternal care for disproportion | Obstructed labour due to maternal pelvic abnormality | Obstructed labour due to deformed pelvis
[GA34.Y] Other specified female pelvic pain associated with genital organs or menstrual cycle
Also known as: Other specified female pelvic pain associated with genital organs or menstrual cycle | Pelvic congestion syndrome | Pelvic varicosities | Female frozen pelvis | Female intrapelvic haemorrhage
[LB30.7] Ectopic or pelvic kidney
Definition: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones
Also known as: Ectopic or pelvic kidney | Congenital displaced kidney | congenital misplaced kidney | congenital malposition of kidney | congenital prolapsed kidney
Includes: Congenital displaced kidney | Malrotation of kidney
[MD82] Intra-abdominal or pelvic swelling, mass or lump
Definition: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation.
Also known as: Intra-abdominal or pelvic swelling, mass or lump | Abdominal mass without further specification | mass in abdomen | intra-abdominal lump | intra-abdominal mass
Excludes: Abdominal distension | Ascites
[GA05.Z] Female pelvic inflammatory diseases, unspecified
Also known as: Female pelvic inflammatory diseases, unspecified | Female pelvic inflammatory diseases | PID - [pelvic inflammatory disease] | pelvic inflammatory disease NOS | Parametritis
=== GRAPH WALKS ===
--- Walk 1 ---
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
--PARENT--> [JB07] Labour or delivery complicated by fetal distress
--CHILD--> [JB07.1] Labour or delivery complicated by meconium in amniotic fluid
Def: A condition characterised by complications during labour and delivery that is caused by meconium in amniotic fluid....
--- Walk 2 ---
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
--PARENT--> [JB07] Labour or delivery complicated by fetal distress
--CHILD--> [JB07.0] Labour or delivery complicated by fetal heart rate anomaly
Def: A condition characterised by an abnormal fetal heart rate. This condition leads to further difficulties and complications during labour and delivery. Confirmation is by Doppler ultrasound....
--- Walk 3 ---
[NE8Y] Other specified injury or harm arising from surgical or medical care, not elsewhere classified
--PARENT--> [?] Injury or harm arising from surgical or medical care, not elsewhere classified
--RELATED_TO--> [?] Complications of anaesthesia during pregnancy
--- Walk 4 ---
[NE8Y] Other specified injury or harm arising from surgical or medical care, not elsewhere classified
--PARENT--> [?] Injury or harm arising from surgical or medical care, not elsewhere classified
--RELATED_TO--> [?] Complications of intrauterine procedures, not elsewhere classified
Def: A group of conditions characterised as an unfavourable evolution of a condition (complication) due to a health intervention applied inside of the uterus....
--- Walk 5 ---
[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother
Def: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother....
--PARENT--> [JA66] Clinical findings on antenatal screening of mother
Def: Any sign characterised by an abnormality detected during an antenatal screening of the mother....
--EXCLUDES--> [?] Maternal care related to the fetus, amniotic cavity or possible delivery problems
Def: A group of conditions characterised by the provision of health interventions to the mother due to conditions associated with the fetus, the amniotic cavity, or to issues associated with labour and del...
--- Walk 6 ---
[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother
Def: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother....
--PARENT--> [JA66] Clinical findings on antenatal screening of mother
Def: Any sign characterised by an abnormality detected during an antenatal screening of the mother....
--CHILD--> [JA66.2] Abnormal cytological finding on antenatal screening of mother
Def: A sign characterised by an abnormality detected by cytology during an antenatal screening of the mother....
|
[
"[JB07.Z] Labour or delivery complicated by fetal distress, unspecified\n --PARENT--> [JB07] Labour or delivery complicated by fetal distress\n --CHILD--> [JB07.1] Labour or delivery complicated by meconium in amniotic fluid\n Def: A condition characterised by complications during labour and delivery that is caused by meconium in amniotic fluid....",
"[JB07.Z] Labour or delivery complicated by fetal distress, unspecified\n --PARENT--> [JB07] Labour or delivery complicated by fetal distress\n --CHILD--> [JB07.0] Labour or delivery complicated by fetal heart rate anomaly\n Def: A condition characterised by an abnormal fetal heart rate. This condition leads to further difficulties and complications during labour and delivery. Confirmation is by Doppler ultrasound....",
"[NE8Y] Other specified injury or harm arising from surgical or medical care, not elsewhere classified\n --PARENT--> [?] Injury or harm arising from surgical or medical care, not elsewhere classified\n --RELATED_TO--> [?] Complications of anaesthesia during pregnancy",
"[NE8Y] Other specified injury or harm arising from surgical or medical care, not elsewhere classified\n --PARENT--> [?] Injury or harm arising from surgical or medical care, not elsewhere classified\n --RELATED_TO--> [?] Complications of intrauterine procedures, not elsewhere classified\n Def: A group of conditions characterised as an unfavourable evolution of a condition (complication) due to a health intervention applied inside of the uterus....",
"[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother\n Def: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother....\n --PARENT--> [JA66] Clinical findings on antenatal screening of mother\n Def: Any sign characterised by an abnormality detected during an antenatal screening of the mother....\n --EXCLUDES--> [?] Maternal care related to the fetus, amniotic cavity or possible delivery problems\n Def: A group of conditions characterised by the provision of health interventions to the mother due to conditions associated with the fetus, the amniotic cavity, or to issues associated with labour and del...",
"[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother\n Def: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother....\n --PARENT--> [JA66] Clinical findings on antenatal screening of mother\n Def: Any sign characterised by an abnormality detected during an antenatal screening of the mother....\n --CHILD--> [JA66.2] Abnormal cytological finding on antenatal screening of mother\n Def: A sign characterised by an abnormality detected by cytology during an antenatal screening of the mother...."
] |
JB07.Z
|
Labour or delivery complicated by fetal distress, unspecified
|
[
{
"from_icd11": "JB07.Z",
"icd10_code": "O68",
"icd10_title": "Labor and delivery complicated by abnormality of fetal acid-base balance"
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O682",
"icd10_title": ""
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O688",
"icd10_title": ""
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O689",
"icd10_title": ""
},
{
"from_icd11": "JA66.3",
"icd10_code": "O283",
"icd10_title": "Abnormal ultrasonic finding on antenatal screening of mother"
},
{
"from_icd11": "JA66.3",
"icd10_code": "O283 ",
"icd10_title": ""
},
{
"from_icd11": "PK9A.1",
"icd10_code": "Y801",
"icd10_title": "Therapeutic (nonsurgical) and rehabilitative physical medicine devices associated with adverse incidents"
},
{
"from_icd11": "FC00.3",
"icd10_code": "M955",
"icd10_title": "Acquired deformity of pelvis"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q632",
"icd10_title": "Ectopic kidney"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q63",
"icd10_title": "Other congenital malformations of kidney"
},
{
"from_icd11": "MD82",
"icd10_code": "R1900",
"icd10_title": "Intra-abdominal and pelvic swelling, mass and lump, unspecified site"
},
{
"from_icd11": "MD82",
"icd10_code": "R1909",
"icd10_title": "Other intra-abdominal and pelvic swelling, mass and lump"
},
{
"from_icd11": "MD82",
"icd10_code": "R1902",
"icd10_title": "Left upper quadrant abdominal swelling, mass and lump"
},
{
"from_icd11": "MD82",
"icd10_code": "R1904",
"icd10_title": "Left lower quadrant abdominal swelling, mass and lump"
},
{
"from_icd11": "MD82",
"icd10_code": "R1903",
"icd10_title": "Right lower quadrant abdominal swelling, mass and lump"
}
] |
O68
|
Labor and delivery complicated by abnormality of fetal acid-base balance
|
A 15-year-old boy was admitted to the Polish Mother’s Memorial Hospital Research Institute (PMMHRI) Emergency Unit due to VC injury. The boy was jumping on beaten and in one of the high jumps missed it, landing on hard ground on the back, without loss of consciousness. Because of the injury and strong pain in the thoracic VC, an ambulance was called and the patient was carried on stiff board to the Emergency Unit. At admission, CT scans were made revealing A2.2 (AO/Magerl) fracture of Th8 and A1.2 (AO/Magerl) of Th9 VB. No neurological symptoms were diagnosed. VAS was estimated on 8/10. The angle of thoracic kyphosos (AK) was 24.5° (all angles were measured on digital pictures with Osirix Computer software). According to TLISS/TLICS and AO/Magerl classification, conservative treatment with long-roll Jevett brace and pharmacotherapy was commissioned. The patient after supply was discharged home with recommendations—long-roll brace, pharmacotherapy, and avoidance of physical exercises. After that, he visited several orthopedics who recommended continuation of conservative and pharmacological treatment. After 6 months, the patient was for the first time seen by a neurosurgeon. Still, the patient was in long-roll brace, no neurological symptoms, and VAS was estimated on 7–8/10. Control CT scan was performed. AK was 31.5° which meant 29 % increase compared to first CT. During all that time, the patient was released from any kind of physical exercises. The patient only attended to school classes and was still on pharmacological painkillers. Oswestry Disability Index (ODI) was evaluated as 48 % which meant severe disability. Because of insufficient conservative treatment, surgical procedures were proposed. The surgical procedure was performed under general anesthesia in standard position for posterior VC approach. To eliminate all inconvenience associated with standard techniques, it was decided to use intravertebral Spine Jack® fixation system offered by Vexim™. To avoid use of pure PMMA cement (Cohesion™), we decided to use Interface™ bone rebuilt cement also offered by Vexim™ in order to target patients with high reossification potential, like young ones. The system was designed for adults and standard implant dimensions are customized to fully growth pedicles. The smallest implant is 4.2 mm in diameter. The pedicle of fractured VB was 4.1 mm. The implant was bigger in diameter than the pedicle itself, not mentioning maintenance of safe 2-mm bone margin around the planned approach. The extrapedicular approach was chosen as the method to place the implant in the planned final location. Spine Jack® 4.2-mm implant was chosen and Interface™ cement. The whole procedure took 45 min. The implants were placed under fluoroscopic imaging . After proper positioning of the implant in Th8 VB , it was fully expanded followed by cementation of the implant and VB with Interface™ bone rebuilt cement (total amount of 1.8cm 3 on side—total volume of 3.6cm 3 ). Cement was applied with very low pressure (indispensable to push through the cement application tubes). After obtaining full hemostasis, sutures were applied on the fascia and skin. The skin incision was 1.5 cm in length on side . After procedure, CT scan was performed revealing proper implant position and proper cement placement . AK was measured at the level of 27.1°—14 % of rebalance was achieved. In postoperative 3D mapping, reduction of fracture is clearly visible especially regarding anterior column of VB (Denis classification) and almost ideal distribution of forces acting on endplates . Surgical procedure was performed in the 25th week after injury. It was an old fracture; in fractures operated till the 6th week after injury, the percentage of height recovery is significantly higher. Complete mobilization of the patient was done 4 h after the procedure. There were no neurological symptoms. Local wound pain was evaluated as VAS = 1/10. There was no need for the brace or pharmacotherapy. The patient was discharged from the hospital 72 h after admission. In the 10th day after the procedure, stitches were removed. The patient was on control visit 1 and 3 and 6 months after the procedure. Control CT was performed. AK is stable at the level of 27.2° on all control studies. There were no pain (VAS = 0/10) and no brace. Postoperative wound was hardly visible . ODI was evaluated as 0 % which meant complete recovery. The patient returned to all activities of daily life and to active outdoor sports. Fig. 1 CT scan of fractured VB (sagittal) Fig. 2 CT scan of fractured VB (axial) Fig. 3 CT scan of fractured VB (coronal) Fig. 4 Spine Jack ® expandable implant Fig. 5 Intraoperative positioning of implant before cementation Fig. 6 Postoperative wound Fig. 7 CT control scan of VB (sagittal) Fig. 8 CT control scan of VB (axial) Fig. 9 CT control scan of VB (coronal) Fig. 10 3D mapping reconstruction of pre- and postoperative VB Fig. 11 3D mapping reconstruction of pre- and postoperative VB Fig. 12 3D mapping reconstruction of pre- and postoperative VB Fig. 13 3D mapping reconstruction of pre- and postoperative VB Fig. 14 Postoperative wound—control
| 4.019531
| 0.970703
|
sec[0]/sec[0]/p[0]
|
en
| 0.999996
|
27669697
|
https://doi.org/10.1007/s00381-016-3250-8
|
[
"implant",
"control",
"scan",
"postoperative",
"cement",
"brace",
"mapping",
"injury",
"fractured",
"wound"
] |
[
{
"code": "GC7A",
"title": "Disorders of breast augmentation"
},
{
"code": "QB51.7",
"title": "Presence of orthopaedic joint implants"
},
{
"code": "QB51.Y",
"title": "Presence of other specified devices other than cardiac or vascular implants"
},
{
"code": "QB51.5",
"title": "Presence of endocrine implants"
},
{
"code": "QB51.6",
"title": "Presence of tooth-root or mandibular implants"
},
{
"code": "6C01.Z",
"title": "Encopresis, unspecified"
},
{
"code": "6C00.Z",
"title": "Enuresis, unspecified"
},
{
"code": "MF50.2Z",
"title": "Urinary incontinence, unspecified"
},
{
"code": "5A14",
"title": "Diabetes mellitus, type unspecified"
},
{
"code": "6C0Z",
"title": "Elimination disorders, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[GC7A] Disorders of breast augmentation
Definition: A group of disorders that may arise in concert with or subsequent to the surgical placement of breast implants.
Also known as: Disorders of breast augmentation | Capsule contraction or scarring | Implant rupture
[QB51.7] Presence of orthopaedic joint implants
Also known as: Presence of orthopaedic joint implants | presence of joint implant | replacement of joint by artificial or mechanical device or prosthesis | Presence of shoulder-joint implant | presence of shoulder joint replacment prosthesis
[QB51.Y] Presence of other specified devices other than cardiac or vascular implants
Also known as: Presence of other specified devices other than cardiac or vascular implants | Presence of bone or tendon implants other than orthopaedic joint implants | replacement of tendon by artificial or mechanical device or prosthesis | presence of tendon implant | Presence of skull plate
[QB51.5] Presence of endocrine implants
Also known as: Presence of endocrine implants | presence of insulin pump
Includes: presence of insulin pump
[QB51.6] Presence of tooth-root or mandibular implants
Also known as: Presence of tooth-root or mandibular implants | presence of tooth root implant | presence of mandibular implant
[6C01.Z] Encopresis, unspecified
Also known as: Encopresis, unspecified | Encopresis | Problems of bowel control | encopresis of nonorganic origin | faecal incontinence of nonorganic origin
[6C00.Z] Enuresis, unspecified
Also known as: Enuresis, unspecified | Enuresis | Functional enuresis | Problems of bladder control | enuresis NOS
[MF50.2Z] Urinary incontinence, unspecified
Also known as: Urinary incontinence, unspecified | Urinary incontinence | urinary incontinence, NOS | bladder incontinence NOS | absence of bladder continence
[5A14] Diabetes mellitus, type unspecified
Also known as: Diabetes mellitus, type unspecified | diabetes NOS | DM - [diabetes mellitus] NOS | severe diabetes mellitus | sudden-onset diabetes mellitus
Excludes: Idiopathic Type 1 diabetes mellitus | Type 2 diabetes mellitus | Diabetes mellitus, other specified type
[6C0Z] Elimination disorders, unspecified
Also known as: Elimination disorders, unspecified | Problems of bowel or bladder control
=== GRAPH WALKS ===
--- Walk 1 ---
[GC7A] Disorders of breast augmentation
Def: A group of disorders that may arise in concert with or subsequent to the surgical placement of breast implants....
--PARENT--> [?] Postprocedural disorders of genitourinary system
Def: Any disorder caused by or subsequent to any intervention of the genitourinary system....
--EXCLUDES--> [?] States associated with artificial menopause
Def: Any condition caused by the artificial cessation of menstruation induced by surgical or pharmacological effects....
--- Walk 2 ---
[GC7A] Disorders of breast augmentation
Def: A group of disorders that may arise in concert with or subsequent to the surgical placement of breast implants....
--PARENT--> [?] Postprocedural disorders of genitourinary system
Def: Any disorder caused by or subsequent to any intervention of the genitourinary system....
--CHILD--> [GC72] Postprocedural urethral stricture
Def: Urethral stricture caused by catheterization, transurethral manipulations (e.g. transurethral resections), urethral instillations, or irradiation exposure...
--- Walk 3 ---
[QB51.7] Presence of orthopaedic joint implants
--PARENT--> [QB51] Presence of devices other than cardiac or vascular implants
--PARENT--> [?] Presence of device, implants or grafts
--- Walk 4 ---
[QB51.7] Presence of orthopaedic joint implants
--PARENT--> [QB51] Presence of devices other than cardiac or vascular implants
--CHILD--> [QB51.1] Presence of urogenital implants
--- Walk 5 ---
[QB51.Y] Presence of other specified devices other than cardiac or vascular implants
--PARENT--> [QB51] Presence of devices other than cardiac or vascular implants
--PARENT--> [?] Presence of device, implants or grafts
--- Walk 6 ---
[QB51.Y] Presence of other specified devices other than cardiac or vascular implants
--PARENT--> [QB51] Presence of devices other than cardiac or vascular implants
--EXCLUDES--> [?] Fitting, adjustment or management of devices
|
[
"[GC7A] Disorders of breast augmentation\n Def: A group of disorders that may arise in concert with or subsequent to the surgical placement of breast implants....\n --PARENT--> [?] Postprocedural disorders of genitourinary system\n Def: Any disorder caused by or subsequent to any intervention of the genitourinary system....\n --EXCLUDES--> [?] States associated with artificial menopause\n Def: Any condition caused by the artificial cessation of menstruation induced by surgical or pharmacological effects....",
"[GC7A] Disorders of breast augmentation\n Def: A group of disorders that may arise in concert with or subsequent to the surgical placement of breast implants....\n --PARENT--> [?] Postprocedural disorders of genitourinary system\n Def: Any disorder caused by or subsequent to any intervention of the genitourinary system....\n --CHILD--> [GC72] Postprocedural urethral stricture\n Def: Urethral stricture caused by catheterization, transurethral manipulations (e.g. transurethral resections), urethral instillations, or irradiation exposure...",
"[QB51.7] Presence of orthopaedic joint implants\n --PARENT--> [QB51] Presence of devices other than cardiac or vascular implants\n --PARENT--> [?] Presence of device, implants or grafts",
"[QB51.7] Presence of orthopaedic joint implants\n --PARENT--> [QB51] Presence of devices other than cardiac or vascular implants\n --CHILD--> [QB51.1] Presence of urogenital implants",
"[QB51.Y] Presence of other specified devices other than cardiac or vascular implants\n --PARENT--> [QB51] Presence of devices other than cardiac or vascular implants\n --PARENT--> [?] Presence of device, implants or grafts",
"[QB51.Y] Presence of other specified devices other than cardiac or vascular implants\n --PARENT--> [QB51] Presence of devices other than cardiac or vascular implants\n --EXCLUDES--> [?] Fitting, adjustment or management of devices"
] |
GC7A
|
Disorders of breast augmentation
|
[
{
"from_icd11": "QB51.7",
"icd10_code": "Z96652",
"icd10_title": "Presence of left artificial knee joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96649",
"icd10_title": "Presence of unspecified artificial hip joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96641",
"icd10_title": "Presence of right artificial hip joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96653",
"icd10_title": "Presence of artificial knee joint, bilateral"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96651",
"icd10_title": "Presence of right artificial knee joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96643",
"icd10_title": "Presence of artificial hip joint, bilateral"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96642",
"icd10_title": "Presence of left artificial hip joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96611",
"icd10_title": "Presence of right artificial shoulder joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96619",
"icd10_title": "Presence of unspecified artificial shoulder joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96612",
"icd10_title": "Presence of left artificial shoulder joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96659",
"icd10_title": "Presence of unspecified artificial knee joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96629",
"icd10_title": "Presence of unspecified artificial elbow joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96661",
"icd10_title": "Presence of right artificial ankle joint"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96691",
"icd10_title": "Finger-joint replacement of right hand"
},
{
"from_icd11": "QB51.7",
"icd10_code": "Z96698",
"icd10_title": "Presence of other orthopedic joint implants"
}
] |
Z96652
|
Presence of left artificial knee joint
|
A 28-year-old Caucasian female with a past medical history of hypothyroidism presented for evaluation of a new onset shortness of breath associated with cough productive of whitish-colored sputum for one week. Few days prior to the presentation, patient visited another medical facility for same complaints where she was diagnosed with community acquired pneumonia for which antibiotics were given. Symptoms progressively worsened despite of being on antibiotics. On the night of presentation patient woke up suddenly due to acute worsening of breathing difficulty. Patient also noted acute worsening of left leg swelling, and that swelling had become painful. Rest of review of symptoms was significant for history of chest tightness for few hours, leg swelling for last two days, exertional dyspnea and nonspecific myalgia for one week. There was no history of sick contacts, recent travel, trauma, fever, or chills. Patient had never smoked prior to presentation. There was no history of prior clotting problem or clotting problem in the family. At the time of presentation patient was taking levothyroxine and birth control pills. Initial vitals at the time of presentation were: blood pressure of 127/68 mm Hg, pulse 92 beats per minute, temperature 98.4 F (36.7°C), respiratory rate of 19 per minute with an oxygen saturation of 97% on room air. Patient was 5 feet 4 inches tall and weighed 290 pounds. Physical exam revealed young obese female in no acute distress; lungs were clear to auscultation; heart rhythm was regular, no added heart sound, murmur, rub, or gallop; abdomen was soft with positive bowel sounds. Significant physical examination findings were, tender erythematous swelling of left leg from ankle to the thigh; left calf measured 22 inches, whereas right calf measured 20 inches; pulses were palpable in bilateral lower extremities. Considering a very high probability of DVT and pulmonary embolism (PE) patient was given one-time dose of therapeutic subcutaneous enoxaparin. Basic workup including complete blood count, comprehensive metabolic panel, chest X-ray, and coagulation profile (international normalized ratio, prothrombin time, and activated partial thromboplastin time) was within normal limits. EKG and transthoracic echocardiogram were within normal limits and were negative for right ventricular strain pattern. Lower extremity doppler was significant for extensive thrombosis of left common femoral, femoral, great saphenous, posterior tibial, popliteal, and peroneal vein as shown in Figures 1(a) – 1(f) . CT scan of chest with intravenous contrast revealed massive bilateral PE ( Figure 2(a) ). CT scan of abdomen and pelvis with intravenous contrast was done to localize extent of the thrombosis and for clinical suspicion of the MTS. CT abdomen supported the diagnosis of MTS as shown in Figures 2(c) and 2(d) and showed extension of the clot all the way through left common iliac vein ( Figure 2(b) ) into inferior vena cava (IVC). Subsequently the patient underwent interventional radiology (IR) guided venography (Figures 3(a) and 3(b) ) and local thrombolysis with the alteplase followed by continuous infusion of alteplase and heparin through catheter laid across femoral and iliac veins with a closer monitoring of CBC and coagulation profile. On a subsequent day patient underwent IR guided venography revealing duplicate femoral veins ( Figure 3(c) ), pharmacomechanical thrombolysis, and thrombectomy of left iliofemoral veins. Thrombolysis was done with use of alteplase and angiojet device. Clot was removed with suction thrombectomy using 6 French-catheter and with mechanical thrombectomy using 14 mm × 3 cm balloon resulting in a significant decrease in the clot burden. Alteplase infusion and heparin therapy was continued with close monitoring. On the subsequent day patient underwent repeat venography which showed no significant thrombus burden but revealed narrowing of the left common iliac vein (Figures 3(d) and 3(e) ) which confirmed the diagnosis of MTS, venoplasty was done, and two stents made of nitinol (nickel-titanium alloy) measuring 14 mm × 8 cm and 14 mm × 3 cm were deployed in iliocaval junction with a good flow through stent into IVC ( Figure 3(f) ). On the subsequent day alteplase was discontinued, heparin was held for concerns of heparin induced thrombocytopenia which later was found to be negative on serotonin release assay, anticoagulation was continued with fondaparinux, and coumadin was started. Patient was also started on aspirin indefinitely and clopidogrel for at least six weeks. Subsequently patient did well and was discharged home on coumadin and a bridging dose of fondaparinux with instructions to closely followup with primary care physician. Patient was instructed to continue coumadin at least for six months unless she was found to have any thrombophilia, to discontinue birth control pills, and use an alternative form of contraception. Subsequent hypercoagulable workup excluded diagnosis of protein C, protein S, antithrombin III deficiency, factor V Leiden mutation, prothrombin gene mutation, antiphospholipid antibody syndrome, and hyperhomocysteinemia.
| 3.929688
| 0.981445
|
sec[1]/p[0]
|
en
| 0.999996
|
23509664
|
https://doi.org/10.1155/2013/740182
|
[
"time",
"alteplase",
"which",
"swelling",
"femoral",
"figures",
"heparin",
"chest",
"inches",
"abdomen"
] |
[
{
"code": "PL13.52",
"title": "Incorrect timing of drug or medicament, as mode of injury"
},
{
"code": "QF2A",
"title": "Difficulty or need for assistance with community participation"
},
{
"code": "MF50.1",
"title": "Pollakiuria"
},
{
"code": "JA25.3",
"title": "Eclampsia, time period unspecified"
},
{
"code": "KD3B.Z",
"title": "Unspecified time of fetal death, cause not specified"
},
{
"code": "BD50.41",
"title": "Abdominal aortic aneurysm with rupture"
},
{
"code": "EK91",
"title": "Dermatoses which may presage cutaneous lymphoma"
},
{
"code": "MH12.1",
"title": "Death occurring less than 24 hours from onset of symptoms, not otherwise explained"
},
{
"code": "8A44.3",
"title": "Certain specified leukodystrophies"
},
{
"code": "FA36.Z",
"title": "Effusion of joint, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[PL13.52] Incorrect timing of drug or medicament, as mode of injury
Also known as: Incorrect timing of drug or medicament, as mode of injury | wrong timing of drug | timing error in giving drug | timing mistake in administration of drug | administration error involving timing of drug
Excludes: Problem with delayed treatment | Overdose of substance, as mode of injury or harm
[QF2A] Difficulty or need for assistance with community participation
Also known as: Difficulty or need for assistance with community participation | difficulty with community participation | need for assistance with community participation | need for assistance with community, social and civic life | difficulty with community, social and civic life
Includes: Lack of relaxation or leisure
[MF50.1] Pollakiuria
Also known as: Pollakiuria | pollakisuria | Daytime frequency of micturition
[JA25.3] Eclampsia, time period unspecified
Definition: Onset of convulsions in a woman with pre-eclampsia not attributable to other causes without a specific onset time.
Also known as: Eclampsia, time period unspecified | Eclampsia NOS | eclamptic coma | eclamptic toxaemia | toxaemia with convulsions
[KD3B.Z] Unspecified time of fetal death, cause not specified
Also known as: Unspecified time of fetal death, cause not specified | Fetal death, cause not specified | stillbirth NOS | stillborn NOS | intrauterine fetal demise
[BD50.41] Abdominal aortic aneurysm with rupture
Also known as: Abdominal aortic aneurysm with rupture | abdominal aorta aneurysm rupture | abdominal aorta aneurysm ruptured | abdominal aortic aneurysm which has ruptured | ruptured AAA
[EK91] Dermatoses which may presage cutaneous lymphoma
Definition: Dermatoses which may represent the earliest stages of cutaneous lymphoma but where it is not possible to confirm their neoplastic nature.
Also known as: Dermatoses which may presage cutaneous lymphoma
[MH12.1] Death occurring less than 24 hours from onset of symptoms, not otherwise explained
Also known as: Death occurring less than 24 hours from onset of symptoms, not otherwise explained | died without sign of disease | Death known not to be violent or instantaneous for which no cause can be discovered | death known not to be violent or instantaneous, cause unknown | Death without sign of disease
Includes: Death known not to be violent or instantaneous for which no cause can be discovered | Death without sign of disease
[8A44.3] Certain specified leukodystrophies
Also known as: Certain specified leukodystrophies | CACH syndrome | Vanishing white matter disease | Childhood ataxia with central nervous system hypomyelination | Congenital or early infantile CACH syndrome
[FA36.Z] Effusion of joint, unspecified
Also known as: Effusion of joint, unspecified | Effusion of joint | effusion into joint | effusion of joint, site unspecified | hydrarthrosis
=== GRAPH WALKS ===
--- Walk 1 ---
[PL13.52] Incorrect timing of drug or medicament, as mode of injury
--EXCLUDES--> [?] Overdose of substance, as mode of injury or harm
Def: Incorrect dose - too high...
--EXCLUDES--> [?] Overdose of substance without injury or harm
Def: Overdose of a substance occurs when a patient is given more of a prescribed drug or other substance than is intended. Can be the result of inaccurate measurement of drug, including oral administration...
--- Walk 2 ---
[PL13.52] Incorrect timing of drug or medicament, as mode of injury
--EXCLUDES--> [?] Overdose of substance, as mode of injury or harm
Def: Incorrect dose - too high...
--EXCLUDES--> [?] Unintentional exposure to or harmful effects of drugs, medicaments or biological substances
--- Walk 3 ---
[QF2A] Difficulty or need for assistance with community participation
--PARENT--> [?] Difficulty or need for assistance with activities
Def: Identifies activities for which the person needs assistance or has such difficulty with, that it affects their need for health services or their treatment....
--CHILD--> [QF20] Difficulty or need for assistance with learning
--- Walk 4 ---
[QF2A] Difficulty or need for assistance with community participation
--PARENT--> [?] Difficulty or need for assistance with activities
Def: Identifies activities for which the person needs assistance or has such difficulty with, that it affects their need for health services or their treatment....
--EXCLUDES--> [?] Dependence on enabling machines or devices
--- Walk 5 ---
[MF50.1] Pollakiuria
--PARENT--> [MF50] Abnormal micturition
--CHILD--> [MF50.2] Urinary incontinence
Def: Any condition of the urinary system, caused by determinants arising during the antenatal period or after birth, leading to loss of voluntary control or support of the urethra. These conditions are cha...
--- Walk 6 ---
[MF50.1] Pollakiuria
--PARENT--> [MF50] Abnormal micturition
--CHILD--> [MF50.0] Frequent micturition
Def: Needing to urinate more often than normal....
|
[
"[PL13.52] Incorrect timing of drug or medicament, as mode of injury\n --EXCLUDES--> [?] Overdose of substance, as mode of injury or harm\n Def: Incorrect dose - too high...\n --EXCLUDES--> [?] Overdose of substance without injury or harm\n Def: Overdose of a substance occurs when a patient is given more of a prescribed drug or other substance than is intended. Can be the result of inaccurate measurement of drug, including oral administration...",
"[PL13.52] Incorrect timing of drug or medicament, as mode of injury\n --EXCLUDES--> [?] Overdose of substance, as mode of injury or harm\n Def: Incorrect dose - too high...\n --EXCLUDES--> [?] Unintentional exposure to or harmful effects of drugs, medicaments or biological substances",
"[QF2A] Difficulty or need for assistance with community participation\n --PARENT--> [?] Difficulty or need for assistance with activities\n Def: Identifies activities for which the person needs assistance or has such difficulty with, that it affects their need for health services or their treatment....\n --CHILD--> [QF20] Difficulty or need for assistance with learning",
"[QF2A] Difficulty or need for assistance with community participation\n --PARENT--> [?] Difficulty or need for assistance with activities\n Def: Identifies activities for which the person needs assistance or has such difficulty with, that it affects their need for health services or their treatment....\n --EXCLUDES--> [?] Dependence on enabling machines or devices",
"[MF50.1] Pollakiuria\n --PARENT--> [MF50] Abnormal micturition\n --CHILD--> [MF50.2] Urinary incontinence\n Def: Any condition of the urinary system, caused by determinants arising during the antenatal period or after birth, leading to loss of voluntary control or support of the urethra. These conditions are cha...",
"[MF50.1] Pollakiuria\n --PARENT--> [MF50] Abnormal micturition\n --CHILD--> [MF50.0] Frequent micturition\n Def: Needing to urinate more often than normal...."
] |
PL13.52
|
Incorrect timing of drug or medicament, as mode of injury
|
[
{
"from_icd11": "QF2A",
"icd10_code": "Z7389",
"icd10_title": "Other problems related to life management difficulty"
},
{
"from_icd11": "QF2A",
"icd10_code": "Z7382",
"icd10_title": "Dual sensory impairment"
},
{
"from_icd11": "QF2A",
"icd10_code": "Z73",
"icd10_title": "Problems related to life management difficulty"
},
{
"from_icd11": "QF2A",
"icd10_code": "Z732",
"icd10_title": "Lack of relaxation and leisure"
},
{
"from_icd11": "QF2A",
"icd10_code": "Z738",
"icd10_title": "Other problems related to life management difficulty"
},
{
"from_icd11": "QF2A",
"icd10_code": "Z739",
"icd10_title": "Problem related to life management difficulty, unspecified"
},
{
"from_icd11": "MF50.1",
"icd10_code": "R351",
"icd10_title": "Nocturia"
},
{
"from_icd11": "MF50.1",
"icd10_code": "R358",
"icd10_title": "Other polyuria"
},
{
"from_icd11": "MF50.1",
"icd10_code": "R35",
"icd10_title": "Polyuria"
},
{
"from_icd11": "JA25.3",
"icd10_code": "O159",
"icd10_title": "Eclampsia, unspecified as to time period"
},
{
"from_icd11": "KD3B.Z",
"icd10_code": "P95",
"icd10_title": "Stillbirth"
},
{
"from_icd11": "BD50.41",
"icd10_code": "I713",
"icd10_title": "Abdominal aortic aneurysm, ruptured"
},
{
"from_icd11": "EK91",
"icd10_code": "L989",
"icd10_title": "Disorder of the skin and subcutaneous tissue, unspecified"
},
{
"from_icd11": "MH12.1",
"icd10_code": "R961",
"icd10_title": ""
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25471",
"icd10_title": "Effusion, right ankle"
}
] |
Z7389
|
Other problems related to life management difficulty
|
A case of a 4-year-old Caucasian man admitted in the Lazzaro Spallanzani National Institute for Infectious Diseases in Rome, Italy, due to “fever in returning travellers” was reported. At admission, the patient, a healthy man with benign prostatic hyperplasia only, in his medical history, was in good condition. He reported one week of asthenia, headache, night sweats, loss of appetite and, the day before, high fever with syncope. The patient reported travel to South Korea and, two weeks earlier, to Guinea Conakry without taking any anti-malarial chemoprophylaxis. On admission, blood tests showed thrombocytopenia (platelet count 50.000/mmc), C-reactive protein (CRP) 10.6 mg/dl, procalcitonin (PCT) 1.05 ng/ml, aspartate aminotransferase 103 U/L, alanine aminotransferase 67 U/L, gamma-glutamyl transferase 173U/L, with normal renal function and coagulation . Pan-malarial rapid test was positive for non-falciparum malaria and Plasmodium vivax rapid test was negative, thick and thin blood smear were positive and showed the presence of P. ovale trophozoites, with a 0.001% parasitaemia (40 parasites/µl). Oral chloroquine, 10 mg/kg as initial dose followed by 10 mg/kg on the second day and 5 mg/kg on the third day, was prescribed. In-house nested-polymerase chain reaction (PCR) confirmed the diagnosis of P. ovale excluding mixed infections . Plasmodium ovale wallikeri was identified by using a nested PCR followed by 2% agarose gel electrophoresis (a 245 bp band confirmed P. o. wallikeri ) and verified with amplicon sequencing . Blood PCR for Leishmania and Dengue were negative; serology for Leishmania , Schistosoma , Strongyloides, Dengue, Chikungunya, HCV, HBV, HIV, HEV, Widal-Wright reaction for Salmonella and blood cultures were negative. Multiplex Real-Time PCR (Norovirus GII, Rotavirus A, Astrovirus, Norovirus G I, Cryptosporidium spp, Entamoeba histolytica , Giardia lamblia , Cyclospora cayetanensis , Vibrio parahaemolyticus , Clostridium difficile toxin A/B, Vibrio vulnificus , Enteropathogenic Escherichia coli , Campylobacter spp., Yersinia enterocolitica , Enterotoxigenic E. coli (It/st), Enteroinvasive E. coli / Shigella . STEC (stx1/stx2), Enteroaggregative E. coli , Salmonella spp., Plesiomonas shigelloides , Sapovirus . Vibrio cholerae STEC-0157:H7, Adenovirus F40/F41) on stool was negative. Posterior-anterior chest X-ray showed bilateral and diffused peribronchovascular thickening and abdominal ultrasound confirmed mild splenomegaly (bipolar diameter 15.5 cm) with homogeneous structure. The day after admission, despite a negative thick smear, the patient’s condition suddenly worsened: he developed dyspnea with a increased respiratory rate of 40 breaths per minute, low peripheral oxygen saturation less than 90%, and acute hypoxaemia confirmed by blood gas analysis. Chest auscultation revealed bilateral crackles in both respiratory phases. The patient started oxygen supplementation with 40% fractional inspired oxygen (FiO2) Venturi mask with improvement of blood gas analysis: PH: 7.47, pCO2: 31, PO2: 104 mmHg with an arterial oxygen tension (PaO2/FiO2 ratio) of 260. Therefore, antibacterial therapy with intravenous ceftriaxone 2 g daily was started. A multiplex Real-Time RT-PCR on sputum was positive for Staphylococcus aureus ; sputum cultures, quantiferon TB Gold, nasopharynx swab for SARS-CoV-2 and pneumococcal/legionella urine antigen test were negative. After 24 h arterial blood gas analysis showed a reduced oxygen tension (pO2 72, pCo2 29, PaO2/FiO2 ratio of 180), Continuous positive airway pressure (CPAP) by using 40%FiO2 Boussignac mask and 5 mmhg positive end-expiratory pressure (PEEP) was started. A chest and abdomen computed tomography scan with intravenous contrast showed interstitial ground glass opacities involving all right and left lobes with early parenchymal lung consolidation, bilateral pleural and pericardium effusion and in the abdomen there was hypodense area with triangular morphology at splenic site . The findings of the CT scan lay for cardiogenic oedema and triangle splenic infarction. The patient had no abdominal pain. Patient fluid balance was initially positive. Intravenous furosemide (20 mg every 12 h) and piperacillin/tazobactam (4.5 g every 8 h), oral doxycycline (100 mg every 12 h), enoxaparin 40 mg subcutaneous daily were started . In the following days, the patient gradually improved with decreasing the needs of oxygen until the definitive ending on day 15 since admission. Oral primaquine (30 mg daily for 14 days) was given after confirming a normal level of glucose-6-phosphate dehydrogenase activity in erythrocytes. The patient was discharged in good clinical condition after 18 days of hospitalization, with normal blood tests. Two weeks later at follow-up visit, blood tests were repeated with unremarkable results and no evidences of sequelae or relapse were reported. Fig. 1 Chest X-ray during at hospital admission Fig. 2 Chest computed tomography during Plasmodium ovale malaria showing interstitial bilateral pneumonia with consensual pleural effusion Fig. 3 Computed tomography during Plasmodium ovale malaria showing splenic infarction
| 4.109375
| 0.969727
|
sec[1]/p[0]
|
en
| 0.999997
|
PMC10993526
|
https://doi.org/10.1186/s12936-024-04911-4
|
[
"blood",
"oxygen",
"ovale",
"chest",
"plasmodium",
"coli",
"malaria",
"oral",
"vibrio",
"intravenous"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "MD11.1",
"title": "Asphyxia"
},
{
"code": "NE60",
"title": "Harmful effects of drugs, medicaments or biological substances, not elsewhere classified"
},
{
"code": "3A51.7",
"title": "High affinity haemoglobin"
},
{
"code": "NF05",
"title": "Asphyxiation"
},
{
"code": "PB08",
"title": "Unintentional threat to breathing from low oxygen environment"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[MD11.1] Asphyxia
Definition: Asphyxia is a life-threatening condition in which oxygen is prevented from reaching the tissues by obstruction of or damage to any part of the respiratory system. More generally the term indicates all the conditions generating impaired or impeded breathing.
Also known as: Asphyxia | pathological asphyxia | decreased oxygen supply | oxygen deficiency | positional asphyxia
Excludes: asphyxia due to foreign body in respiratory tract | asphyxia due to carbon monoxide | asphyxia due to traumatic
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
Also known as: Harmful effects of drugs, medicaments or biological substances, not elsewhere classified | drugs, medicaments or biological substances, toxicity not elsewhere classified | adverse drug effects | drug reaction NOS | drug allergy NOS
Excludes: Alcohol intoxication | pathological drug intoxication | hypersensitivity reaction to correctly administered drug
[3A51.7] High affinity haemoglobin
Definition: A disease caused by determinants arising after birth, in the antenatal period or by genetically inherited factors leading to high oxygen affinity haemoglobin. This disease is characterised by abnormalities in the globin chains that alter the affinity of the haemoglobin molecule for oxygen, affecting the normal loading of oxygen in the lungs and delivery of oxygen to the tissues.
Also known as: High affinity haemoglobin | Haemoglobins with abnormal oxygen affinity
[NF05] Asphyxiation
Also known as: Asphyxiation | suffocation NOS | traumatic asphyxia | positional asphyxiation | asphyxia (ligature)
Excludes: Respiratory distress of newborn | Adult acute respiratory distress syndrome | asphyxia from carbon monoxide
[PB08] Unintentional threat to breathing from low oxygen environment
Also known as: Unintentional threat to breathing from low oxygen environment | confined to or trapped in a low-oxygen environment | Accidental mechanical suffocation in refrigerator | Diving with insufficient air supply | Accidentally shut in other airtight space
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues
Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Certain conditions originating in the perinatal period
Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.4Z] Haematuria, unspecified
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.40] Macroscopic haematuria
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues\n Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Certain conditions originating in the perinatal period\n Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.4Z] Haematuria, unspecified",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.40] Macroscopic haematuria",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
As soon as the diagnosis was made, continued perfusion of unfractionated heparin was performed to maintain an APTT of 60–80 s. Subsequently, the patient underwent interventional therapy in the angiography room. AngioJet (Boston Scientific, Marlborough, Massachusetts, USA) pharmacomechanical thrombectomy and transluminal balloon angioplasty were immediately performed. The process was as follows: the sheath was inserted into the left femoral vein using Seldinger’s method. Cavography was performed routinely in the anteroposterior and lateral positions using a 5-F pigtail catheter (Cordis, Tipperary, Ireland) to confirm the absence of thrombosis in the IVC and access veins. An Aegisy vena cava filter (LifeTech Scientific Co. Ltd, Shenzhen, China) was then placed in the IVC to prevent pulmonary embolism. Ultrasound-guided sheathing of the right popliteal vein and 5-F pigtail catheterization revealed filling defects in the allograft, anastomosis, and right lower extremity veins (comparable to the CT findings) with collateral circulation and contrast reflux. A 0.035-inch guidewire (Radifocus®; Terumo, Tokyo, Japan) fed into a 5-F VER catheter (Cordis, Tipperary, Ireland) was introduced from the right popliteal vein, into the allograft vein, and into the IVC through the thrombus. The Amplatz Fixed Core Wire Guide (Boston Scientific) was introduced to guide the AngioJet Thrombectomy catheter Solent™ Omni (Boston Scientific) to the thrombus lumen. Local injection thrombolysis mode (PowerPulse™ Delivery) was used. Afterward, 250 mL of 0.9% NaCl solution containing 200,000 units of urokinase was injected into the thrombus. Urokinase was retained for 30 min, and then the rheological suction mode for thrombus aspiration was implemented 4 . Following the aforementioned procedures, angiography showed a dislodged thrombus captured below the IVC filter. Thrombus residue occupied the venous lumen causing segmental narrowing in the veins of the allograft and the right lower extremity, including the anastomosis. Balloon (Boston Scientific, Marlborough, Massachusetts, USA) angioplasty was performed until 12 atm for 3 min followed by repeated aspiration venous thrombectomy, and total blood loss was controlled within 200 mL. The final phlebography showed patency with excellent flow in allograft, anastomosis, and the ipsilateral lower extremities . Iodixanol (150 mL; 32 g iodine per 100 mL) was used during the procedure. Figure 3 ( a )–( e ): DSA post-anterior view showing filling defects in the proximal main vein of the transplanted kidney and the right popliteal vein, femoral vein, common femoral vein, external iliac vein and common iliac vein. ( a ): The red arrow shows a limited filling defect at the confluence of the vein of the transplanted kidney into the right external iliac vein. ( b ): The lumen of the original vascular filling defect in the vein of the transplanted kidney, shown by the red arrow, is open and restored to its normal lumen diameter. Pharmarcomechanical mechanical thrombectomy plus transluminal balloon angioplasty after post-DSA contrast angiography shows a significant improvement in the lumen of the former limited filling defect in the vein of the transplanted kidney after treatment, with contrast filling. ( c ): Blue arrows show contrast filling defects and stagnant flow in the lumen of the right external iliac vein and common iliac vein. ( d ): Patency of the right external iliac vein and common iliac vein lumen, as indicated by the blue arrows, with thrombus clearance and smooth contrast reflux. The original right lower limb DVT-filled vessel lumen was largely cleared and the vessel lumen was restored to patency with smooth contrast return, no contrast stagnation, reflux or collateral vessel formation was observed. ( e ): Free thrombus captured underneath the pre-positioned inferior vena cava filter shown by the green arrow. Partial thrombus dislodgement during Pharmarcomechanical mechanical thrombectomy plus transluminal balloon angioplasty, DSA angiography shows a limited filling defect in the lumen of the inferior vena cava below the filter as a dislodged thrombus. ( f )–( g ): Doppler ultrasound 6 months after surgery. ( f ): Six months after the operation, Doppler ultrasound showed that the transplanted kidney could be detected in the right iliac fossa, with normal kidney morphology, parenchymal echogenicity, and no significant abnormalities in the renal sinuses. End-lateral anastomosis of the renal artery to the right external iliac artery, average renal artery resistance index, RI: 0.82, end-lateral anastomosis of the renal vein to the right external iliac vein. No significant abnormalities in renal artery and renal vein blood flow were noted. (The lumen of the aortic vessel of the transplanted kidney is patent, as indicated by the red arrow) (The lumen of the central vein of the transplanted kidney is patent, as indicated by the blue arrow). ( g ): The right common femoral, femoral, deep femoral, anterior tibial, posterior tibial, and popliteal veins are normal in diameter, with good intraventricular sound, unobstructed flow, and average flow spectrum pattern.
| 4.011719
| 0.950195
|
sec[1]/sec[1]/p[0]
|
en
| 0.999995
|
37828079
|
https://doi.org/10.1038/s41598-023-44514-8
|
[
"vein",
"lumen",
"thrombus",
"iliac",
"filling",
"kidney",
"contrast",
"transplanted",
"femoral",
"renal"
] |
[
{
"code": "BD7Z",
"title": "Diseases of veins, unspecified"
},
{
"code": "MC88",
"title": "Prominent veins"
},
{
"code": "BD7Y",
"title": "Other specified diseases of veins"
},
{
"code": "BD75.Y",
"title": "Venous varicosities of other specified sites"
},
{
"code": "BD73.2Z",
"title": "Systemic vein obstruction, unspecified"
},
{
"code": "BA41.Z",
"title": "Acute myocardial infarction, unspecified"
},
{
"code": "PL12.3",
"title": "Obstruction of device, as mode of injury or harm"
},
{
"code": "BD5Y",
"title": "Other specified diseases of arteries or arterioles"
},
{
"code": "BA60.7&XA91S4",
"title": "Atrial thrombus as current complication following acute myocardial infarction"
},
{
"code": "BA60.7&XA7XU8",
"title": "Ventricular thrombus as current complication following acute myocardial infarction"
}
] |
=== ICD-11 CODES FOUND ===
[BD7Z] Diseases of veins, unspecified
Also known as: Diseases of veins, unspecified
[MC88] Prominent veins
Also known as: Prominent veins
[BD7Y] Other specified diseases of veins
Also known as: Other specified diseases of veins
[BD75.Y] Venous varicosities of other specified sites
Also known as: Venous varicosities of other specified sites | Caput medusae | Jugular venous aneurysm | jugular vein aneurysm | Orbital varices
[BD73.2Z] Systemic vein obstruction, unspecified
Also known as: Systemic vein obstruction, unspecified | Systemic vein obstruction
[BA41.Z] Acute myocardial infarction, unspecified
Also known as: Acute myocardial infarction, unspecified | Acute myocardial infarction | cardiac attack | heart attack | acute cardiac infarction
[PL12.3] Obstruction of device, as mode of injury or harm
Definition: Obstruction associated with prosthetic devices, grafts or implants
Also known as: Obstruction of device, as mode of injury or harm | occlusion shunt | blockage of device causing obstruction as mode of injury | blocked tube causing obstruction as mode of injury | occlusion of device causing obstruction as mode of injury
Excludes: Obstruction of device without injury or harm
[BD5Y] Other specified diseases of arteries or arterioles
Also known as: Other specified diseases of arteries or arterioles | Arterial or microvascular embolism classified by source | Cardiac embolism | heart embolism | Thrombotic cardiac embolism
=== GRAPH WALKS ===
--- Walk 1 ---
[BD7Z] Diseases of veins, unspecified
--PARENT--> [?] Diseases of veins
--RELATED_TO--> [?] Venous complications in pregnancy
--- Walk 2 ---
[BD7Z] Diseases of veins, unspecified
--PARENT--> [?] Diseases of veins
--RELATED_TO--> [?] Venous complications in pregnancy
--- Walk 3 ---
[MC88] Prominent veins
--PARENT--> [?] Symptoms or signs involving the circulatory system
--CHILD--> [MC80] Abnormal blood-pressure reading, without diagnosis
Def: Abnormal blood-pressure reading, without diagnosis is a reading of blood pressure which is higher than normal blood pressure or lower than normal blood pressure, without diagnosis....
--- Walk 4 ---
[MC88] Prominent veins
--PARENT--> [?] Symptoms or signs involving the circulatory system
--CHILD--> [MC82] Cardiac arrest
Def: A sudden, sometimes temporary, cessation of heart function resulting in hemodynamic collapse....
--- Walk 5 ---
[BD7Y] Other specified diseases of veins
--PARENT--> [?] Diseases of veins
--RELATED_TO--> [?] Other venous complications following abortion, ectopic or molar pregnancy
--- Walk 6 ---
[BD7Y] Other specified diseases of veins
--PARENT--> [?] Diseases of veins
--CHILD--> [BD72] Venous thromboembolism
|
[
"[BD7Z] Diseases of veins, unspecified\n --PARENT--> [?] Diseases of veins\n --RELATED_TO--> [?] Venous complications in pregnancy",
"[BD7Z] Diseases of veins, unspecified\n --PARENT--> [?] Diseases of veins\n --RELATED_TO--> [?] Venous complications in pregnancy",
"[MC88] Prominent veins\n --PARENT--> [?] Symptoms or signs involving the circulatory system\n --CHILD--> [MC80] Abnormal blood-pressure reading, without diagnosis\n Def: Abnormal blood-pressure reading, without diagnosis is a reading of blood pressure which is higher than normal blood pressure or lower than normal blood pressure, without diagnosis....",
"[MC88] Prominent veins\n --PARENT--> [?] Symptoms or signs involving the circulatory system\n --CHILD--> [MC82] Cardiac arrest\n Def: A sudden, sometimes temporary, cessation of heart function resulting in hemodynamic collapse....",
"[BD7Y] Other specified diseases of veins\n --PARENT--> [?] Diseases of veins\n --RELATED_TO--> [?] Other venous complications following abortion, ectopic or molar pregnancy",
"[BD7Y] Other specified diseases of veins\n --PARENT--> [?] Diseases of veins\n --CHILD--> [BD72] Venous thromboembolism"
] |
BD7Z
|
Diseases of veins, unspecified
|
[
{
"from_icd11": "BD7Z",
"icd10_code": "I82412",
"icd10_title": "Acute embolism and thrombosis of left femoral vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82621",
"icd10_title": "Acute embolism and thrombosis of deep veins of right upper extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82432",
"icd10_title": "Acute embolism and thrombosis of left popliteal vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82C11",
"icd10_title": "Acute embolism and thrombosis of right internal jugular vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82441",
"icd10_title": "Acute embolism and thrombosis of right tibial vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82422",
"icd10_title": "Acute embolism and thrombosis of left iliac vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82622",
"icd10_title": "Acute embolism and thrombosis of deep veins of left upper extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I824Z1",
"icd10_title": "Acute embolism and thrombosis of unspecified deep veins of right distal lower extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82401",
"icd10_title": "Acute embolism and thrombosis of unspecified deep veins of right lower extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I824Z2",
"icd10_title": "Acute embolism and thrombosis of unspecified deep veins of left distal lower extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82612",
"icd10_title": "Acute embolism and thrombosis of superficial veins of left upper extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82721",
"icd10_title": "Chronic embolism and thrombosis of deep veins of right upper extremity"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82C12",
"icd10_title": "Acute embolism and thrombosis of left internal jugular vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82B12",
"icd10_title": "Acute embolism and thrombosis of left subclavian vein"
},
{
"from_icd11": "BD7Z",
"icd10_code": "I82421",
"icd10_title": "Acute embolism and thrombosis of right iliac vein"
}
] |
I82412
|
Acute embolism and thrombosis of left femoral vein
|
The present study describes the case of a young pregnant woman diagnosed with OS in the distal fibula, who was successfully treated with surgery and adjuvant chemotherapy. It is important to highlight that the woman in the present case report had no evident risk factors for developing OS. Thus, this clearly demonstrates the unpredictable nature of this neoplasm in young individuals. Fortunately, long-term follow-up reports for this woman indicate that both she and the gestational product are in good health, with no pathologies linked to the primary tumor or arising from the treatment. Notably, the occurrence of neoplasms during pregnancy is rare, with an incidence of ~1 case per 1,000 pregnancies ( 11 ). A previous review suggested that the incidence of OS in pregnant women may be on the rise due to the increasing trend of delaying pregnancy until later ages ( 12 ). However, the age of the patient in the present study does not align with this trend. Therefore, it can be hypothesized that the patient in the present case report likely had more subtle risk factors that predisposed her to develop this neoplastic lesion, probably of a polygenic nature or related to specific age-related risk factors. As regards the latter, a previous retrospective study observed that the age group of 15 to 25 years was the one with the most significant increase in OS diagnoses over recent decades compared with other age groups ( 13 ). Additionally, previous reports have documented incidental diagnoses of OS in pregnant women and women on reproductive age while they were being treated for other conditions ( 14 , 15 ). In the patient described herein, the clinical manifestations observed were consistent with the typical presentations of OS in the appendicular skeleton ( 16 ). The initial evaluation of the edema and pain involved an ankle X-ray, which revealed radiodense and lytic lesions typical of this neoplasm ( 17 ). Although positron emission tomography is the ideal diagnostic tool for identifying metastases ( 18 ), herein, its use was restricted due to the pregnancy of the patient. Consequently, contrast-enhanced MRI was employed, as it effectively visualizes the extent of soft tissue involvement and the overall disease progression ( 17 , 19 ). In the absence of metastasis, surgical treatment combined with adjuvant chemotherapy was selected. Previous studies have demonstrated that this approach can preserve the affected limb and ensure a favorable long-term prognosis ( 9 , 20 ). Although surgery is a valid approach for treating localized stages of osteosarcoma, it can cause localized cellular stress, potentially leading to immune dysregulation and increasing the risk of tumor recurrence over time ( 21 ). Considering this and the young age of the patient in the present case report, the medical team decided on a combined treatment plan of surgery and adjuvant chemotherapy. Drug management during pregnancy has historically been contentious; advancements in pharmacokinetics and pharmacovigilance now support the safe use of medications during pregnancy for both the mother and fetus ( 22 , 23 ). In addition, recent advancements in therapies, particularly those utilizing nanoparticles, have demonstrated their effectiveness in the treatment of OS ( 24 ). However, the availability of antineoplastic drugs in the authors' hospital (Hospital Star Médica Chihuahua) is limited. Consequently, the selection of the medication was based on the established therapeutic efficacy of the drug for this type of cancer. Since the 1970s, the use of cisplatin has been shown to be associated with improved survival rates in OS by 90% and extended relapse-free periods by 60% ( 25 ). However, in the case described herein, cisplatin and doxorubicin were selected, as it remains effective at low doses for these lesions ( 26-28 ). The follow-up data confirmed a satisfactory antitumor response in the patient, along with the birth of the product without significant complications. As regards the treatment used, while the management of OS depends on the tumor stage, it is also closely aligned with the treatment protocols specific to each hospital ( 29 ). Cytotoxic therapies used in OS include alkylating agents (ifosfamide and cisplatin), antimetabolites (methotrexate and gemcitabine), topoisomerase inhibitors (etoposide), anthracyclines (doxorubicin), or microtubule inhibitors. Additionally, recent studies suggest that PD-1 inhibitors may serve as an effective adjuvant immunotherapy for patients with OS who have already undergone standard chemotherapy; this treatment has the potential to increase survival rates and lower the risk of long-term tumor recurrence ( 30 , 31 ). Other potential treatments include RNA silencers and certain nucleotide analogs, which have proven effective in other types of solid tumors. However, these are still in phase I and II clinical trials: and will require time before they become standard practice ( 32 ). In the authors' opinion, the treatment selected for the patient in the present case report was the most suitable, considering her personal circumstances and the available resources at the hospital.
| 4.324219
| 0.701172
|
sec[2]/p[0]
|
en
| 0.999998
|
39483928
|
https://doi.org/10.3892/mi.2024.197
|
[
"this",
"that",
"present",
"risk",
"pregnancy",
"adjuvant",
"chemotherapy",
"tumor",
"however",
"pregnant"
] |
[
{
"code": "4A01.03",
"title": "Transient hypogammaglobulinaemia of infancy"
},
{
"code": "8A80.Z",
"title": "Migraine, unspecified"
},
{
"code": "QA76",
"title": "Medication or substance that is known to be an allergen without injury or harm"
},
{
"code": "PL13.6",
"title": "Medication or substance that is known to be an allergen, as mode of injury or harm"
},
{
"code": "9C40.A0",
"title": "Papilloedema"
},
{
"code": "PA6Z",
"title": "Unintentional fall from unspecified height"
},
{
"code": "JA82.2",
"title": "Maternal care for transverse or oblique lie"
},
{
"code": "JA82.1",
"title": "Maternal care for breech presentation"
},
{
"code": "JA82.Z",
"title": "Maternal care for malpresentation of fetus, unspecified"
},
{
"code": "JA82.6",
"title": "Maternal care for compound presentation"
}
] |
=== ICD-11 CODES FOUND ===
[4A01.03] Transient hypogammaglobulinaemia of infancy
Also known as: Transient hypogammaglobulinaemia of infancy | immunoglobulin maturational delay | THI - [transient hypogammaglobulinaemia of infancy]
[8A80.Z] Migraine, unspecified
Also known as: Migraine, unspecified | Migraine
[QA76] Medication or substance that is known to be an allergen without injury or harm
Definition: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm.
Also known as: Medication or substance that is known to be an allergen without injury or harm
Excludes: Medication or substance that is known to be an allergen, as mode of injury or harm
[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm
Also known as: Medication or substance that is known to be an allergen, as mode of injury or harm | medication error relating to known allergy to drug or substance | adverse drug event relating to known allergy to drug or substance
[9C40.A0] Papilloedema
Definition: Optic disc swelling that results from increased intracranial pressure
Also known as: Papilloedema | Optic disc swelling that results from increased intracranial pressure
Includes: Optic disc swelling that results from increased intracranial pressure
[PA6Z] Unintentional fall from unspecified height
Also known as: Unintentional fall from unspecified height | fall NOS | accidental fall | fall causing injury that resulted in death | fell NOS
[JA82.2] Maternal care for transverse or oblique lie
Also known as: Maternal care for transverse or oblique lie | Maternal care for oblique presentation | Maternal care for prolapse of arm or hand | Maternal care for transverse presentation of fetus | transverse presentation
[JA82.1] Maternal care for breech presentation
Also known as: Maternal care for breech presentation | breech fetal presentation | breech presentation | malposition of fetus in breech presentation | positions of breech presentation
[JA82.Z] Maternal care for malpresentation of fetus, unspecified
Also known as: Maternal care for malpresentation of fetus, unspecified | Maternal care for malpresentation of fetus | abnormal fetal presentation | malpresentation of fetus | fetal malpresentation
[JA82.6] Maternal care for compound presentation
Also known as: Maternal care for compound presentation | compound presentation of fetus
=== GRAPH WALKS ===
--- Walk 1 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--CHILD--> [4A01.02] Specific antibody deficiency with normal immunoglobulin concentrations or normal number of B cells
--- Walk 2 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--CHILD--> [4A01.01] Immunodeficiencies with severe reduction in at least two serum immunoglobulin isotypes with normal or low numbers of B cells
Def: This refers to a nonfamilial type of primary immune deficiency disease characterised by a reduction in at least two serum immunoglobulin isotypes. Circulating B cells may be normal or low....
--- Walk 3 ---
[8A80.Z] Migraine, unspecified
--PARENT--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
--CHILD--> [8A80.1] Migraine with aura
Def: Recurrent attacks, lasting minutes, of unilateral fully-reversible visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by headache and asso...
--- Walk 4 ---
[8A80.Z] Migraine, unspecified
--PARENT--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
--CHILD--> [8A80.1] Migraine with aura
Def: Recurrent attacks, lasting minutes, of unilateral fully-reversible visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by headache and asso...
--- Walk 5 ---
[QA76] Medication or substance that is known to be an allergen without injury or harm
Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....
--EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--- Walk 6 ---
[QA76] Medication or substance that is known to be an allergen without injury or harm
Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....
--EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
|
[
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --CHILD--> [4A01.02] Specific antibody deficiency with normal immunoglobulin concentrations or normal number of B cells",
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --CHILD--> [4A01.01] Immunodeficiencies with severe reduction in at least two serum immunoglobulin isotypes with normal or low numbers of B cells\n Def: This refers to a nonfamilial type of primary immune deficiency disease characterised by a reduction in at least two serum immunoglobulin isotypes. Circulating B cells may be normal or low....",
"[8A80.Z] Migraine, unspecified\n --PARENT--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...\n --CHILD--> [8A80.1] Migraine with aura\n Def: Recurrent attacks, lasting minutes, of unilateral fully-reversible visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by headache and asso...",
"[8A80.Z] Migraine, unspecified\n --PARENT--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...\n --CHILD--> [8A80.1] Migraine with aura\n Def: Recurrent attacks, lasting minutes, of unilateral fully-reversible visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by headache and asso...",
"[QA76] Medication or substance that is known to be an allergen without injury or harm\n Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....\n --EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance",
"[QA76] Medication or substance that is known to be an allergen without injury or harm\n Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....\n --EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance"
] |
4A01.03
|
Transient hypogammaglobulinaemia of infancy
|
[
{
"from_icd11": "4A01.03",
"icd10_code": "D807",
"icd10_title": "Transient hypogammaglobulinemia of infancy"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43B0",
"icd10_title": "Ophthalmoplegic migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43409",
"icd10_title": "Hemiplegic migraine, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43A0",
"icd10_title": "Cyclical vomiting, in migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43D0",
"icd10_title": "Abdominal migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43709",
"icd10_title": "Chronic migraine without aura, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43A1",
"icd10_title": "Cyclical vomiting, in migraine, intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43509",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43719",
"icd10_title": "Chronic migraine without aura, intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43501",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, with status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43C0",
"icd10_title": "Periodic headache syndromes in child or adult, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43401",
"icd10_title": "Hemiplegic migraine, not intractable, with status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43419",
"icd10_title": "Hemiplegic migraine, intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43B1",
"icd10_title": "Ophthalmoplegic migraine, intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43C1",
"icd10_title": "Periodic headache syndromes in child or adult, intractable"
}
] |
D807
|
Transient hypogammaglobulinemia of infancy
|
After formal consent of the owner, the patient underwent general anesthesia, using a standard clinical protocol: fasting for 12 h and free access to water; premedication was performed with methadone (0.2 mg/kg IV; Semfortan, Dechra Pharmaceutics, Northwich, UK); 10 min after premedication, anesthesia was induced with propofol (4 mg/kg IV; PropoVet, Zoetis Italia S.r.l., Rome, Italy) and midazolam (0.2 mg/kg IV; Midazolam Accord Healthcare, Accord Healthcare Italia S.r.l., Milan, Italy) through a cephalic venous cannula previously and aseptically placed. Following tracheal intubation, the dog was connected to a rebreathing circuit (50 mL/kg oxygen flow) and maintained with isoflurane (1.2–2.0%; Isoflo, Zoetis Italia S.r.l, Rome, Italy) in 100% oxygen. The patient was mechanically ventilated during anesthesia. Lactated Ringer solution (10 mL/kg/h CRI) was infused during the entire anesthetic procedure. Meloxicam (0.2 mg/kg, SC; Metacam, Boehringer Ingelheim Italia S.p.a., Milan, Italy) and cefazolin (30 mg/kg IV; Cefazolina Teva, Teva Italia S.r.l., Assago, Italy) were administered during patient preparation and at least 120 min prior to surgery. After the routine aseptically preparation of the operative field, a ventral midline sternotomy was performed. Intraoperative echocardiography was used to evaluate the localization of the foreign body and confirm its position through the interventricular septum. The pericardium did not show any modification. A small pericardiectomy (4 × 4 cm) was carried out to provide a clearer exposure of the epicardium wall. A small bulging round area was noted at the apex of the left ventricular wall; however, the quill was not yet visible on the cardiac surface. An ultrasound probe, encased in a sterile protective cover, was placed over the cardiac apex and intraoperative ultrasonography allowed to visualize the quill and its tip. A double horizontal mattress suture tension (3-0 polypropylene) was placed in the epicardium wall around the area of the tip of the quill (at about 10 mm from the apex of the heart). Under ultrasonographic direct visualization, a small (8 mm) incision of the ventricular wall was carried out by n. 11 scalpel blade; the depth of the incision was about 6 mm; through the incision, a small, curved tip hemostatic forceps were introduced, and under ultrasound guide, the quill was grasped and gently pulled out from the heart . No cardiac arrhythmias were recorded during the removal of the quill. A swab of the area housing the quill was performed, and the double sutures were tightened to prevent hemorrhage. The swab, as well as the quill, were submitted for aerobic and anaerobic culture. Intraoperative ultrasonographic examination performed after the removal did not visualize any fragmented parts of the extracted quill. The thoracic cavity was explored to rule out lung lobes damage. Before closure, the chest cavity was flushed with a lukewarm sterile saline solution and inspected for air leakage from the lung lobes. A 12 French gauge thoracostomy tube was inserted in the left hemithorax. The thoracic cavity was closed with 18-gauge stainless steel wires placed around the sternebrae in an X-cross interrupted pattern. The pectoral muscles were closed with 0 polydioxanone sutures in a cruciate mattress pattern technique. The subcutaneous tissues were closed with a simple continuous pattern of 3-0 polydioxanone, and the skin was closed with an intradermic simple continuous pattern of 4-0 poliglecaprone. Following surgery, the dog was weaned from mechanical ventilation without complication. Recovery from anesthesia was uneventful, with extubation 15 min after inhalant anesthesia was discontinued. The thoracostomy tube was removed 24 h later. Initial treatment post-operatively included cefazolin (30 mg/kg IV q12 h; Cefazolina Teva, Teva Italia S.r.l., Assago, Italy), lactated Ringer’s solution (2 mL/kg/h IV), and meloxicam (0.1 mg/kg SC q24 h, Metacam, Boehringer Ingelheim Italia S.p.a., Noventana, Italy). For pain management, the initial treatment included methadone (Semfortan, Dechra Pharmaceutics, Northwich, UK) 0.2 mg/kg IM q4 h. Two days post-operatively, results from the cultures revealed the growth of an amoxicillin-resistant Pseudomonas aeruginosa with sensitivity to amikacin, gentamicin, enrofloxacin, and marbofloxacin. Therefore, antibiotic therapy was changed to enrofloxacin (5 mg/kg PO q24 h for six weeks; Baytril Flavour, Elanco Italia S.p.a, Sesto Fiorentino, Italy). A few days after the surgery, a surgical site infection (SSI) of the wound involving pectoral muscles was noted and treated by surgical curettage of the sternal area, local swab for antimicrobial testing, and abundant lavage. Two days later, preliminary culture results from the infected wound indicated growth of Pseudomonas aeruginosa that was only sensitive to clindamycin, amikacin, gentamicin, enrofloxacin, and marbofloxacin. Amikacin (10 mg/kg; Amikacina Teva, Teva Italia S.r.l., Assago, Italy) was infiltrated locally three times a week. The wound improved, and the draining tract resolved, so the dog was discharged after four weeks after the surgery.
| 4.136719
| 0.874023
|
sec[1]/sec[1]/p[0]
|
en
| 0.999997
|
36548861
|
https://doi.org/10.3390/vetsci9120700
|
[
"italia",
"italy",
"quill",
"teva",
"anesthesia",
"small",
"wall",
"area",
"closed",
"pattern"
] |
[
{
"code": "1D45",
"title": "Sandfly fever"
},
{
"code": "MB40.3",
"title": "Anaesthesia of skin"
},
{
"code": "9A78.6",
"title": "Anaesthesia of cornea"
},
{
"code": "MG30.5Z",
"title": "Chronic neuropathic pain, unspecified"
},
{
"code": "JA67.Z",
"title": "Complications of anaesthesia during pregnancy, unspecified"
},
{
"code": "JB43.Z",
"title": "Complications of anaesthesia during the puerperium, unspecified"
},
{
"code": "MF54.2",
"title": "Small kidney"
},
{
"code": "DA9Z",
"title": "Diseases of small intestine, unspecified"
},
{
"code": "GA16.Y",
"title": "Other specified acquired abnormalities of uterus, except cervix"
},
{
"code": "KA20.0Z",
"title": "Small for gestational age, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[1D45] Sandfly fever
Also known as: Sandfly fever | sandfly-borne phleboviral disease | pappataci fever | phlebotomus fever | three day fever
Includes: pappataci fever | phlebotomus fever
[MB40.3] Anaesthesia of skin
Definition: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy.
Also known as: Anaesthesia of skin | Hypoaesthesia of skin | Loss of cutaneous sensation | Numbness of skin | Loss of sensation
Includes: Numbness of skin
[9A78.6] Anaesthesia of cornea
Definition: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber.
Also known as: Anaesthesia of cornea | corneal anaesthesia
[MG30.5Z] Chronic neuropathic pain, unspecified
Also known as: Chronic neuropathic pain, unspecified | Chronic neuropathic pain | anaesthesia dolorosa | neuralgia | chronic neurogenic pain (deprecated)
[JA67.Z] Complications of anaesthesia during pregnancy, unspecified
Also known as: Complications of anaesthesia during pregnancy, unspecified | Complications of anaesthesia during pregnancy
[JB43.Z] Complications of anaesthesia during the puerperium, unspecified
Also known as: Complications of anaesthesia during the puerperium, unspecified | Complications of anaesthesia during the puerperium
[MF54.2] Small kidney
Definition: A condition characterised by a kidney smaller in size and weight than the average (less than 11 centimetres long, 5-7.5 centimetres wide, 2.5 centimetres thick, and weighing less than 120 grams).
Also known as: Small kidney | Small kidney, unilateral | unilateral small kidney | Small kidney, bilateral
[DA9Z] Diseases of small intestine, unspecified
Also known as: Diseases of small intestine, unspecified
[GA16.Y] Other specified acquired abnormalities of uterus, except cervix
Also known as: Other specified acquired abnormalities of uterus, except cervix | Polyp of corpus uteri | intrauterine polyp | polyp of body of uterus | polyp of uterus
[KA20.0Z] Small for gestational age, unspecified
Also known as: Small for gestational age, unspecified | Small for gestational age | Small-for-dates | small fetus or newborn for gestational age | dysmaturity
=== GRAPH WALKS ===
--- Walk 1 ---
[1D45] Sandfly fever
--PARENT--> [?] Certain arthropod-borne viral fevers
--RELATED_TO--> [?] Central European tick-borne encephalitis
--- Walk 2 ---
[1D45] Sandfly fever
--PARENT--> [?] Certain arthropod-borne viral fevers
--RELATED_TO--> [?] Dengue
Def: Dengue is a viral disease transmitted by the bite of a mosquito infected by dengue viruses. It is one disease entity with different clinical presentations and often with unpredictable clinical evoluti...
--- Walk 3 ---
[MB40.3] Anaesthesia of skin
Def: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy....
--PARENT--> [MB40] Sensation disturbance
--CHILD--> [MB40.0] Asomatognosia
--- Walk 4 ---
[MB40.3] Anaesthesia of skin
Def: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy....
--PARENT--> [MB40] Sensation disturbance
--CHILD--> [MB40.1] Allodynia
Def: Pain due to a normally non-painful stimulus...
--- Walk 5 ---
[9A78.6] Anaesthesia of cornea
Def: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber....
--PARENT--> [9A78] Certain specified disorders of cornea
--CHILD--> [9A78.2] Corneal oedema
--- Walk 6 ---
[9A78.6] Anaesthesia of cornea
Def: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber....
--PARENT--> [9A78] Certain specified disorders of cornea
--RELATED_TO--> [?] Ocular laceration or rupture with prolapse or loss of intraocular tissue, unilateral
Def: Forcible or traumatic tearing or breaking of the eyeball with protrusion or loss of the tissues and fluids located within the eyeball....
|
[
"[1D45] Sandfly fever\n --PARENT--> [?] Certain arthropod-borne viral fevers\n --RELATED_TO--> [?] Central European tick-borne encephalitis",
"[1D45] Sandfly fever\n --PARENT--> [?] Certain arthropod-borne viral fevers\n --RELATED_TO--> [?] Dengue\n Def: Dengue is a viral disease transmitted by the bite of a mosquito infected by dengue viruses. It is one disease entity with different clinical presentations and often with unpredictable clinical evoluti...",
"[MB40.3] Anaesthesia of skin\n Def: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy....\n --PARENT--> [MB40] Sensation disturbance\n --CHILD--> [MB40.0] Asomatognosia",
"[MB40.3] Anaesthesia of skin\n Def: Partial or complete loss of sensation affecting the skin, most commonly affecting a circumscribed area and resulting from sensory nerve damage as from injury or leprosy....\n --PARENT--> [MB40] Sensation disturbance\n --CHILD--> [MB40.1] Allodynia\n Def: Pain due to a normally non-painful stimulus...",
"[9A78.6] Anaesthesia of cornea\n Def: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber....\n --PARENT--> [9A78] Certain specified disorders of cornea\n --CHILD--> [9A78.2] Corneal oedema",
"[9A78.6] Anaesthesia of cornea\n Def: This is the condition of having sensation (including the feeling of pain) blocked or temporarily taken away, of the transparent front part of the eye that covers the iris, pupil, and anterior chamber....\n --PARENT--> [9A78] Certain specified disorders of cornea\n --RELATED_TO--> [?] Ocular laceration or rupture with prolapse or loss of intraocular tissue, unilateral\n Def: Forcible or traumatic tearing or breaking of the eyeball with protrusion or loss of the tissues and fluids located within the eyeball...."
] |
1D45
|
Sandfly fever
|
[
{
"from_icd11": "1D45",
"icd10_code": "A931",
"icd10_title": "Sandfly fever"
},
{
"from_icd11": "MB40.3",
"icd10_code": "R200",
"icd10_title": "Anesthesia of skin"
},
{
"from_icd11": "MB40.3",
"icd10_code": "R201",
"icd10_title": "Hypoesthesia of skin"
},
{
"from_icd11": "JA67.Z",
"icd10_code": "O298X1",
"icd10_title": "Other complications of anesthesia during pregnancy, first trimester"
},
{
"from_icd11": "JA67.Z",
"icd10_code": "O29",
"icd10_title": "Complications of anesthesia during pregnancy"
},
{
"from_icd11": "JA67.Z",
"icd10_code": "O295",
"icd10_title": "Other complications of spinal and epidural anesthesia during pregnancy"
},
{
"from_icd11": "JA67.Z",
"icd10_code": "O298",
"icd10_title": "Other complications of anesthesia during pregnancy"
},
{
"from_icd11": "JA67.Z",
"icd10_code": "O299",
"icd10_title": "Unspecified complication of anesthesia during pregnancy"
},
{
"from_icd11": "JB43.Z",
"icd10_code": "O898",
"icd10_title": "Other complications of anesthesia during the puerperium"
},
{
"from_icd11": "JB43.Z",
"icd10_code": "O89",
"icd10_title": "Complications of anesthesia during the puerperium"
},
{
"from_icd11": "JB43.Z",
"icd10_code": "O893",
"icd10_title": "Toxic reaction to local anesthesia during the puerperium"
},
{
"from_icd11": "JB43.Z",
"icd10_code": "O899",
"icd10_title": "Complication of anesthesia during the puerperium, unspecified"
},
{
"from_icd11": "MF54.2",
"icd10_code": "N270",
"icd10_title": "Small kidney, unilateral"
},
{
"from_icd11": "MF54.2",
"icd10_code": "N279",
"icd10_title": "Small kidney, unspecified"
},
{
"from_icd11": "MF54.2",
"icd10_code": "N271",
"icd10_title": "Small kidney, bilateral"
}
] |
A931
|
Sandfly fever
|
We evaluated a 24-year-old Syrian female with active chronic Crohn’s disease, diagnosed 11 years ago. She was classified as A1L3B1P according to the Montreal classification . She had no prior surgical history; her past medications included azathioprine 2.5 mg/kg/day since diagnosis until now and prednisolone 1 mg/kg up to 40 mg during flares, then tapering . Furthermore, she did not use oral contraceptive pills. Her weight was 50 kg, her height was 161 cm, and she had a body mass index of 19.29 kg/m 2 . She complained of watery, bloody diarrhea up to eight times a day, accompanied by abdominal pain in the prior month. Her Crohn’s disease activity index (CDAI) was 390 points. Initial blood tests confirmed leukocytosis, anemia, elevated fecal calprotectin (FC), and C-reactive protein (CRP) levels. Stool cultures, Clostridium difficile toxin, Escherichia coli , and Cryptosporidium , as well as microscopy for ova and parasites, all returned negative. The hypercoagulability work-up revealed negative results for anti-Beta-2 Glycoprotein-1 IgM antibodies, antinuclear antibodies (ANA), fibrinogen, protein S (activity), antithrombin III, and homocysteine, whereas lupus anticoagulant (LA1, LA2) was positive. Factor II mutation and factor V Leiden mutation were normal, whereas the methylenetetrahydrofolate reductase mutation was a homozygous mutant gene. The portal system and suprahepatic vein ultrasound revealed a thrombus that covered nearly half of the lumen of the portal vein and splenomegaly. Gogastroduodenoscopy showed grade I esophageal varices (less than 5 mm, without bleeding risk signs), which indicate portal vein hypertension owing to splenomegaly and esophageal varices. In light of the patient’s recent onset of abdominal pain and the absence of portosystemic collaterals on Doppler ultrasound, a recent PVT is a strong possibility . The colonoscopy revealed several deep ulcers in the sigmoid, rectum, and descending colon Fig. 1 . The biopsies were negative for Clostridium difficile , and immunohistochemical staining was negative for cytomegalovirus (CMV) . The median liver stiffness measured by FibroScan was 2.4 kPa, which suggests the absence of fibrosis. Protein electrophoresis was normal. The abdomen and pelvis contrast-enhanced computed tomography (CT) scan confirmed the PVT and displayed thickening in the descending colon . Antiphospholipid syndrome was initially diagnosed on the basis of an antiphospholipid profile, a history of PVT (thrombotic event), and an association with Crohn’s disease . She initially received corticosteroids to achieve disease remission, followed by ustekinumab to induce and maintain therapy (390 mg intravenous induction followed by 90 mg subcutaneous every 8 weeks) owing to moderate-to-severe Crohn’s disease unresponsive to azathioprine . She began on low-molecular-weight heparin (LMWH) for 1 week, and warfarin for 3 months with an international normalized ratio (INR) target of 2–3. The lupus anticoagulant (LA1, LA2) was retested after 12 weeks and returned to negative , so we switched to apixaban, a novel oral anticoagulant (NOAC) . The 1-year reevaluation indicated clinical, biochemical, and endoscopic remission with CDAI of 150 points, normal lab test, and normal endoscopy. The patient’s tests are presented in Table 1 . Despite 1 year of treatment, a CT scan revealed no improvement in portal vein recanalization. We continued 90 mg of subcutaneous (SC) ustekinumab every 8 weeks, while we stopped apixaban . Fig. 1 Colonoscopy revealed several ulcerations in the sigmoid, rectum, and descending colon Fig. 2 The contrast-enhanced computed tomography scan of the abdomen, which shows portal vein thrombosis Table 1 Patient’s tests Test On admission 1 year later Normal limits Unit WBC 13,200 6300 4500–10500 /mm 3 Hemoglobin 9.9 11.2 12–16 g/dl Platelets 73 119 150–450 X 1000 mm 3 Urea 28 19 15–54 mg/dl Creatinine 0.11 0.13 0.5–1.3 mg/dl ANA Negative < 1/40 titer ASMA Negative < 1/20 titer AMA-M2 Negative titer CRP 36 5 Up to 6 mg/l Fecal calprotectin 520 49 < 150 µg/g ALT 11 13 5–45 U/L AST 35 20 8–40 U/L Total bilirubin 0.8 0.9 0.5–1.2 mg/dl Direct bilirubin 0.2 0.2 0–0.3 mg/dl Total protein 7.2 7.5 6.2–8 g/dl Albumin 4.2 4.6 3.8–5.1 g/dl INR 1.2 1 Glucose 89 86 74–106 mg/dl Uric acid 3.2 2.9 2.5–6.5 mg/dl HBsAg Negative Anti-HCV Negative Anti beta-2 glycoprotein-1 IgM antibodies < 3 < 12 U/mL Antinuclear antibodies (ANA) Hep-2 cells and primate liver by IFA Negative Up to 1/40 Fibrinogen 304.1 280 180–380 mg/dl Lupus anticoagulant LA 1 84.8 Negative 31–44 Sec LA2 70.7 Negative 30–38 Sec Protein S (activity) 147 115 60–150 % Antithrombin III (activity) 95 60–150 % Homocysteine (total) 9.86 4.6–12.5 umol/L Thyroid-stimulating hormone 1.76 0.27–4.2 uIU/ml Factor II mutation Normal Factor V Leiden mutation Normal Methylenetetrahydrofolate reductase mutation Homozygous mutant gene WBC white blood cells, ANA antinuclear antibody, CRP C-reactive protein, ALT alanine aminotransferase, AST aspartate aminotransferase, INR international normalized ratio, HbsAg hepatitis B surface antigen, Anti-HCV hepatitis C antibody, HbcAb hepatitis B core antibody
| 4.128906
| 0.97168
|
sec[1]/p[0]
|
en
| 0.999997
|
38741148
|
https://doi.org/10.1186/s13256-024-04560-w
|
[
"protein",
"mutation",
"portal",
"vein",
"crohn",
"activity",
"anti",
"antibodies",
"anticoagulant",
"factor"
] |
[
{
"code": "5B71",
"title": "Protein deficiency"
},
{
"code": "5B7Z",
"title": "Unspecified undernutrition"
},
{
"code": "DA96.02",
"title": "Malabsorption or intolerance of specific nutrients"
},
{
"code": "MF96.Z",
"title": "Proteinuria, unspecified"
},
{
"code": "3B61.1",
"title": "Acquired thrombophilia"
},
{
"code": "GB90.4A",
"title": "Nephrogenic diabetes insipidus"
},
{
"code": "8A02.12",
"title": "Dystonia associated with heredodegenerative disorders"
},
{
"code": "4A01.21",
"title": "Immune dysregulation syndromes presenting primarily with autoimmunity"
},
{
"code": "8C73.Z",
"title": "Mitochondrial myopathies, unspecified"
},
{
"code": "8E02.0",
"title": "Genetic Creutzfeldt-Jakob disease"
}
] |
=== ICD-11 CODES FOUND ===
[5B71] Protein deficiency
Also known as: Protein deficiency | protein deprivation
[5B7Z] Unspecified undernutrition
Also known as: Unspecified undernutrition | Malnutrition NOS | nutritional deficiency NOS | nutritional depletion NOS | severe malnutrition NOS
[DA96.02] Malabsorption or intolerance of specific nutrients
Definition: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken for food allergy, which is primarily involving the immune reaction against the food.
Also known as: Malabsorption or intolerance of specific nutrients | Carbohydrate intolerance other than lactose | disorder of carbohydrate absorption | Malabsorption due to intolerance to carbohydrate | carbohydrate intolerance
[MF96.Z] Proteinuria, unspecified
Also known as: Proteinuria, unspecified | Proteinuria | Albuminuria NOS | Proteinuria NOS
[3B61.1] Acquired thrombophilia
Definition: A disease caused by determinants arising after birth. This disease is characterised by abnormality of blood coagulation that increases the risk of thrombosis, clots in blood vessels. This disease may present with deep vein thrombosis or pulmonary embolism. Confirmation is identification of abnormal blood coagulation in a blood sample.
Also known as: Acquired thrombophilia | Gaisbock syndrome | polycythaemia due to stress | stress erythrocytosis | stress polycythaemia
[GB90.4A] Nephrogenic diabetes insipidus
Definition: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipatio
Also known as: Nephrogenic diabetes insipidus | renal diabetes insipidus | familial nephrogenic diabetes | antidiuretic-hormone-resistant diabetes insipidus | adiuretin-resistant diabetes insipidus
Excludes: Central diabetes insipidus
[8A02.12] Dystonia associated with heredodegenerative disorders
Definition: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen.
Also known as: Dystonia associated with heredodegenerative disorders | Dystonia due to autosomal dominant disorders | Rapid-onset dystonia-parkinsonism | Dystonia due to dentatorubropallidoluysian atrophy | Dystonia due to Huntington disease
[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity
Also known as: Immune dysregulation syndromes presenting primarily with autoimmunity | Syndrome with autoimmunity | Immunodeficiency syndromes presenting primarily with autoimmunity | FADD-related immunodeficiency | X-linked immune dysregulation – polyendocrinopathy – enteropathy
[8C73.Z] Mitochondrial myopathies, unspecified
Also known as: Mitochondrial myopathies, unspecified | Mitochondrial myopathies | Myopathies in mitochondrial disorders
[8E02.0] Genetic Creutzfeldt-Jakob disease
Definition: A disease of the brain, that is associated with a prion. This disease is characterised by neurological deficits, and is fatal. Confirmation is by pathological examination of the brain.
Also known as: Genetic Creutzfeldt-Jakob disease | CJD - [Creutzfeldt-Jakob disease] | Creutzfeldt-Jakob | Creutzfeldt-Jakob disease | JCD - [Jakob-Creutzfeldt disease]
=== GRAPH WALKS ===
--- Walk 1 ---
[5B71] Protein deficiency
--PARENT--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--EXCLUDES--> [?] Effects of hunger
--- Walk 2 ---
[5B71] Protein deficiency
--PARENT--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--EXCLUDES--> [?] Intestinal malabsorption
Def: Intestinal malabsorption (syndrome) occurs due to pathological interference with the normal physiological sequence of digestion (intraluminal process), absorption (mucosal process), and transport (pos...
--- Walk 3 ---
[5B7Z] Unspecified undernutrition
--PARENT--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--RELATED_TO--> [?] Fetal intrauterine malnutrition without mention of small for gestational age
Def: Neonate, not light or small for gestational age, showing signs of fetal malnutrition, such as dry, peeling skin or loss of subcutaneous tissue....
--- Walk 4 ---
[5B7Z] Unspecified undernutrition
--PARENT--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--CHILD--> [5B52] Acute malnutrition in infants, children or adolescents
--- Walk 5 ---
[DA96.02] Malabsorption or intolerance of specific nutrients
Def: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken ...
--PARENT--> [DA96.0] Intestinal malabsorption
Def: Intestinal malabsorption (syndrome) occurs due to pathological interference with the normal physiological sequence of digestion (intraluminal process), absorption (mucosal process), and transport (pos...
--RELATED_TO--> [?] Neonatal malabsorption syndromes
--- Walk 6 ---
[DA96.02] Malabsorption or intolerance of specific nutrients
Def: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken ...
--RELATED_TO--> [?] Lactose intolerance
Def: Lactose intolerance is the inability to digest lactose, a sugar found in milk and some dairy products, due to a deficiency of lactase, the enzyme that metabolizes lactose. Lactose intolerance occurs w...
--CHILD--> [?] Secondary lactase deficiency
Def: This form of lactase deficiency results from some sort of damage to the intestines either due to a disease or surgery....
|
[
"[5B71] Protein deficiency\n --PARENT--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...\n --EXCLUDES--> [?] Effects of hunger",
"[5B71] Protein deficiency\n --PARENT--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...\n --EXCLUDES--> [?] Intestinal malabsorption\n Def: Intestinal malabsorption (syndrome) occurs due to pathological interference with the normal physiological sequence of digestion (intraluminal process), absorption (mucosal process), and transport (pos...",
"[5B7Z] Unspecified undernutrition\n --PARENT--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...\n --RELATED_TO--> [?] Fetal intrauterine malnutrition without mention of small for gestational age\n Def: Neonate, not light or small for gestational age, showing signs of fetal malnutrition, such as dry, peeling skin or loss of subcutaneous tissue....",
"[5B7Z] Unspecified undernutrition\n --PARENT--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...\n --CHILD--> [5B52] Acute malnutrition in infants, children or adolescents",
"[DA96.02] Malabsorption or intolerance of specific nutrients\n Def: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken ...\n --PARENT--> [DA96.0] Intestinal malabsorption\n Def: Intestinal malabsorption (syndrome) occurs due to pathological interference with the normal physiological sequence of digestion (intraluminal process), absorption (mucosal process), and transport (pos...\n --RELATED_TO--> [?] Neonatal malabsorption syndromes",
"[DA96.02] Malabsorption or intolerance of specific nutrients\n Def: Food intolerance is a term used for difficulty in digesting a food due to various physiological responses associated with a particular food, or compound found. Food intolerance should not be mistaken ...\n --RELATED_TO--> [?] Lactose intolerance\n Def: Lactose intolerance is the inability to digest lactose, a sugar found in milk and some dairy products, due to a deficiency of lactase, the enzyme that metabolizes lactose. Lactose intolerance occurs w...\n --CHILD--> [?] Secondary lactase deficiency\n Def: This form of lactase deficiency results from some sort of damage to the intestines either due to a disease or surgery...."
] |
5B71
|
Protein deficiency
|
[
{
"from_icd11": "5B71",
"icd10_code": "E46",
"icd10_title": "Unspecified protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E440",
"icd10_title": "Moderate protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E441",
"icd10_title": "Mild protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E640",
"icd10_title": "Sequelae of protein-calorie malnutrition"
},
{
"from_icd11": "5B71",
"icd10_code": "E44",
"icd10_title": "Protein-calorie malnutrition of moderate and mild degree"
},
{
"from_icd11": "5B71",
"icd10_code": "E45",
"icd10_title": "Retarded development following protein-calorie malnutrition"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E43",
"icd10_title": "Unspecified severe protein-calorie malnutrition"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E538",
"icd10_title": "Deficiency of other specified B group vitamins"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E569",
"icd10_title": "Vitamin deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E638",
"icd10_title": "Other specified nutritional deficiencies"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E639",
"icd10_title": "Nutritional deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E41",
"icd10_title": "Nutritional marasmus"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E539",
"icd10_title": "Vitamin B deficiency, unspecified"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E568",
"icd10_title": "Deficiency of other vitamins"
},
{
"from_icd11": "5B7Z",
"icd10_code": "E649",
"icd10_title": "Sequelae of unspecified nutritional deficiency"
}
] |
E46
|
Unspecified protein-calorie malnutrition
|
A 66-year-old man visited our hospital complaining of fever with chill which has started three days prior. The patient had a history of appendectomy for appendicitis, hypertension, hyperuricemia, and gastroesophageal reflux disease, which were managed with allopurinol 100 mg once a daily, amlodipine 5 mg once a daily, and vonoprazan 20 mg once a daily. The patient had no history of dental treatment in the past decade. The patient drank about 2 glasses of Awamori, a type of rice wine with 30–40 % alcohol content unique to Okinawa, daily and has smoked 60 cigarettes a day for past 44 years. He denied having sexual intercourse in the past year and denied having homosexual intercourse. Vital signs on arrival showed a temperature of 39.7°, heart rate of 128 beat per minute, blood pressure of 106/62 mmHg, SpO 2 of 95 % in room air. Physical examination showed that his conscious was clear, and his abdomen was soft and had no significant tenderness. Laboratory tests revealed high hepatic enzymes and C-reactive protein (CRP), and increased white blood cells with neutrocyte dominant ( Table 1 ). Computed tomography (CT) scan revealed that the small hypodense area in S4 and a huge hypodense area with the well-defined boundary of more than 100 mm in diameter in S5–6 . Initially, we suspected metastatic liver tumor, but we could not rule out liver abscess, thus the patient was admitted to our hospital to start intravenous administration of meropenem 1.0 g per 8 h after collected two sets of blood culture. On the hospital day 8, blood culture on admission day reported Streptococcus intermedius was positive in both two sets. In view of the findings of bacteremia and low-density area in the liver on CT scan, we finally diagnosed pyogenic liver abscess. We could not point out any other abscesses through head and body imaging. Based on bacterial susceptibility, antibiotics was changed from meropenem to ceftriaxone 2 g per a day plus metronidazole 500 mg per 8 h. We had recommended percutaneous drainage to the patient, but he refused because of needle phobia, thus we continue antibiotics alone. His fever resolved on the day 5 and CRP was on downtrend with the treatment . Two sets of blood cultures taken on days 8 and 15 were both negative. On the day 27, the patient again had a fever of 38.3 degrees, and tested for SARS-CoV-2 antigen was positive. Because of the outbreak in the hospital, he was diagnosed with nosocomial COVID-19, however his symptom was recovered within 2 days. On day 29, blood test showed white blood cell count of 2900/µL, whose percentages of neutrophil was 40.7 %. Because of the gradual decrease in white blood cell count, drug-induced neutropenia was suspected, and vonoprazan was discontinued and filgrastim 75 µg was administered. On the day 40, neutrophil counts were recovered to 4400/µL with 52 % of neutrocyte. A total of 6 weeks of antimicrobial therapy was completed on day 40, and we confirmed that liver abscess had been almost completely diminished on enhanced CT scan . Esophagogastroduodenoscopy (EGD) and colonoscopy (CS) were performed to search the bacterial entry. There was no suspicious findings of on esophagus and stomach, but there were the brownish stains under the patient’s teeth, suggesting that periodontal disease . CS revealed diverticulum and 0-Isp polyp on sigmoid colon; pathological diagnosis was low grade tubular adenoma. After discharge from our hospital on day 42, the patient was followed up in an outpatient clinic for 3 months. There was no recurrence of liver abscess and no elevation of CRP. Table 1 Laboratory data on the day of admission. Table 1 Hematology Chemistry White blood cells 14,500 /µL Total bilirubin 2.3 mg/dL Hemoglobin A1c 6.0 % Lymphocyte 3.2 % Direct bilirubin 1.0 mg/dL Total Protein 6.6 g/dL Neutrocyte 87.7 % Amylase 54 U/L Albumin 2.6 g/dL Eosinocyte 0 % Aspartate aminotransferase 134 U/L Sodium 125 mmol/L Basocyte 0.1 % Alanine aminotransferase 91 U/L Potassium 3.1 mmol/L Red blood cells 446 × 10 4 /µL Lactate dehydrogenase 323 U/L Chloride 88 mmol/L Hemoglobin 14.6 g/dL γ-Glutamyl transpeptidase 202 IU/L Calcium 8.3 mg/dL Hematocrit 36.9 % Alkaline phosphatase 104 IU/L C-reactive protein > 32.0 mg/dL Mean corpuscular volume 94.6 fL Blood urea nitrogen 22.5 mg/dL Procalcitonin > 10.0 ng/mL Platelets 14.5 × 10 4 /µL Serum creatinine 1.42 mg/dL Estimated glomerular filtration rate 40.0 mL/min/1.73 m 2 Fig. 1 Enhanced Computed tomography scan series of liver abscess. There is multifocal liver abscess (white arrowhead) in S4, S5–6 of the liver on Day 1 and 10. Liver abscess appears to have resolved on day 40. Fig. 1 Fig. 2 C-reactive protein (CRP) and Body temperature (BT) during treatment. The patient presented with high CRP level on admission day, however it rapidly downtrending after starting antibiotics therapy. BT was transiently elevated by COVID-19 on day 27–29 but remained normal after treatment. (*: Due to the testing equipment, the upper limit for CRP was 32, and the exact value was not known.). Fig. 2 Fig. 3 Image of the oral cavity of the patient and the findings of periodontal disease (white arrowheads). Fig. 3
| 3.806641
| 0.982422
|
sec[1]/p[0]
|
en
| 0.999997
|
PMC9801097
|
https://doi.org/10.1016/j.idcr.2022.e01662
|
[
"blood",
"liver",
"abscess",
"white",
"daily",
"that",
"protein",
"scan",
"fever",
"past"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--PARENT--> [?] ICD-11 for Mortality and Morbidity Statistics
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--CHILD--> [?] Diseases of spleen
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --PARENT--> [?] ICD-11 for Mortality and Morbidity Statistics",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --CHILD--> [?] Diseases of spleen",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
A 37-year-old asymptomatic female patient was referred to our hospital with an enlarged cardiac silhouette found on her screening chest X-ray . She had no history of cardiovascular disease. She had a spontaneous abortion 3 years previously, and she is a mother of three children. She has a positive family history of cardiovascular diseases and cancer (lung adenocarcinoma and brain tumour). Physical examination revealed distant heart sounds, a regular rate and rhythm. The echocardiographic examination revealed pericardial effusion and an inhomogeneous mobile mass located in the pericardial sac around the left ventricle . Subsequently, cardiac magnetic resonance imaging (MRI) was performed, which showed an intrapericardial, semilunar-shaped mass with a size of 10 × 4 × 9 cm attached to the pulmonary trunk surrounding the aortic root, left atrium and left ventricle . The tumour had well-demarcated margins and did not invade the blood vessels or myocardium. The caudal part of the tumour was mobile, while its cranial part was fixed to the pulmonary trunk (Additional file 2 ). The MRI scan detected intermediate signal intensity on proton density-weighted images and high signal intensity on T2-weighted spectral fat saturation inversion recovery (SPIR) images . Both first-pass perfusion and early and late gadolinium-enhanced (LGE) images showed that the mass was vascularized and showed septated, patchy, inhomogeneous LGE . Coronary computed tomography angiography (CTA) was performed to see whether the coronary arteries were affected. The coronary CTA proved that coronaries were not invaded by the tumour . We have evaluated the previous screening chest X-rays of the patient that were acquired during the past 10 years. Based on these chest X-rays, we can conclude that the mass had started to form at least 7 years ago . No abnormalities were found by the abdominal ultrasound examination, the results of hormone tests were normal, and a hormone-secreting nature of the tumour was excluded. Open heart surgery was indicated through median sternotomy . The intraoperative findings confirmed the MRI and coronary CTA results. The tumour was intrapericardial, attached to the lateral wall of the pulmonary trunk, 2 cm distal from the commissures of the pulmonary valve. The tumour did not invade any other structures of the heart. Complete resection of the tumour with partial resection of the pulmonary trunk was performed using cardiopulmonary bypass. The pulmonary trunk was reconstructed with a round-shaped bovine pericardial patch . The intra- and postoperative course were uneventful. Histological evaluation of the septated, cystic mass revealed tumour cells forming an irregular pattern, the so-called “patternless pattern” . Immunohistochemically, the cells tested positive for vimentin, CD34, CD99 and STAT6 but negative for keratin (AE1-AE3), CD31 and S100. Thus, the diagnosis of a primary cardiac solitary fibrous tumour (SFT) was established. The tumour was classified as non-malignant because of the lack of increased mitotic activity, an intact capsule and no sign of vascular invasion. Regular and long-term clinical and MRI follow-up were indicated (every 6 months in the first year, later annually) because of the risk of late local recurrence. At the 3-year follow-up, the patient had no symptoms, and MRI did not show recurrence of the tumour . The patient’s clinical history is summarized in a timeline, prepared in accordance with CARE guideline (Additional file 3 ). Fig. 1 Chest X-ray examinations performed in 2004 (panel a ), 2007 (panel b ), 2010 (panel c ) and in 2014 (panel d ). Arrows show the enlarged cardiac silhouette Fig. 2 Transthoracic 2D echocardiography in the parasternal long-axis plane (panel a ), short-axis plane (panel b ) and apical four-chamber view (panel c ). Arrows show the intrapericardial mass Fig. 3 Cine movie MRI images in the long- (panel a , b ) and short-axis planes in diastolic phase (panel c and d ). Intermediate signal intensity on proton density-weighted images (panel e ) and high signal intensity on T2-weighted SPIR images (panel f ). LGE images in the long- (panel g ) and short-axis planes (panel h ). Arrows show the intrapericardial tumour Fig. 4 Coronary CTA images (panel a : axial plane, panel b : two-chamber view reconstruction) showed that coronary arteries were not invaded by the tumour. Arrows show the left anterior descending artery Fig. 5 The intraoperative images show the complete resection of the tumour and partial resection of the pulmonary trunk (panel a ). The pulmonary trunk was reconstructed using the pericardial patch technique (panel b ). The encapsulated giant tumour with the size of 10 × 11 × 4 cm; the arrow shows the resected part of the pulmonary trunk (panel c ) Fig. 6 Histology: Haematoxylin and eosin, spindle-shaped cells with the “patternless pattern” (panel a , b ). Immunohistochemistry: the cells were positive for vimentin (panel c ), CD34 (panel d ), CD99 (panel e ) and STAT6 (panel f ) Fig. 7 Cine movie MRI images in transverse planes in the diastolic phase before surgery ( a - c ) and at the three-year follow-up ( d - f )
| 4.082031
| 0.971191
|
sec[1]/p[0]
|
en
| 0.999997
|
28865431
|
https://doi.org/10.1186/s12885-017-3574-0
|
[
"panel",
"tumour",
"pulmonary",
"trunk",
"coronary",
"that",
"cardiac",
"chest",
"pericardial",
"intrapericardial"
] |
[
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
},
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "LA75.1",
"title": "Agenesis of lung"
},
{
"code": "CA40.Z",
"title": "Pneumonia, organism unspecified"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "NB32.3Y",
"title": "Other injury of lung"
}
] |
=== ICD-11 CODES FOUND ===
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[LA75.1] Agenesis of lung
Definition: This refers to the absence or rudimentary residua of an undeveloped lung.
Also known as: Agenesis of lung | Pulmonary agenesis | absence of lung | aplasia of lung | apulmonism
[CA40.Z] Pneumonia, organism unspecified
Also known as: Pneumonia, organism unspecified | Pneumonia | infectious pneumonia | PN - [pneumonia] | lobar pneumonia NOS
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[NB32.3Y] Other injury of lung
Also known as: Other injury of lung | Haematoma of lung | Traumatic hydropneumothorax | Acute traumatic lung congestion | Rupture of lung
=== GRAPH WALKS ===
--- Walk 1 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--PARENT--> [02] Neoplasms
Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....
--- Walk 2 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs
--- Walk 3 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--PARENT--> [?] Symptoms or signs involving the skin
Def: This category allows the capture of imprecise data where a more specific diagnosis cannot be made or to supplement information about a specific diagnosis....
--CHILD--> [ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--- Walk 4 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--PARENT--> [?] General symptoms
--- Walk 5 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs
--- Walk 6 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E60] Carcinoma in situ of oral cavity, oesophagus or stomach
|
[
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --PARENT--> [02] Neoplasms\n Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....",
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --PARENT--> [?] Symptoms or signs involving the skin\n Def: This category allows the capture of imprecise data where a more specific diagnosis cannot be made or to supplement information about a specific diagnosis....\n --CHILD--> [ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --PARENT--> [?] General symptoms",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E61] Carcinoma in situ of other or unspecified digestive organs",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E60] Carcinoma in situ of oral cavity, oesophagus or stomach"
] |
2F9Z
|
Neoplasms of unknown behaviour of unspecified site
|
[
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2242",
"icd10_title": "Localized swelling, mass and lump, left lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2231",
"icd10_title": "Localized swelling, mass and lump, right upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2241",
"icd10_title": "Localized swelling, mass and lump, right lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2233",
"icd10_title": "Localized swelling, mass and lump, upper limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2243",
"icd10_title": "Localized swelling, mass and lump, lower limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2230",
"icd10_title": "Localized swelling, mass and lump, unspecified upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R220",
"icd10_title": "Localized swelling, mass and lump, head"
}
] |
D487
|
Neoplasm of uncertain behavior of other specified sites
|
The patient was a 6-year-old boy born via normal delivery at 39 weeks of gestation to nonconsanguineous parents without any specific family history. His mother had no remarkable pre- or perinatal history. His parents brought him to a secondary care hospital on the 28th day after birth due to sudden-onset feeding difficulty and impaired consciousness. Brain CT and magnetic resonance imaging (MRI) revealed high-intensity signals in the bilateral thalamus, putamen and globus pallidus . Metabolic encephalopathy was suspected, and he was transferred to a tertiary care center on the same day for more intensive treatment and diagnostic tests. His CSF levels of lactate and pyruvate were slightly elevated (lactate/pyruvate: CSF 2.6/0.15 mmol/L, normal range of lactate <1.8 mmol/L, CSF L/P ratio 16.7, normal range <15). Neonatal tandem mass screening showed no abnormalities. Urine organic acid analysis revealed elevated dicarboxylic acid (adipic acid, suberic acid, sebacic acid), 3-OH-butyrate and acetoacetate levels. After 3 weeks of hospitalization, the patient was diagnosed with Leigh syndrome based on the MRI findings and elevated lactate level. Vitamin treatment (thiamine 6.6 mg/kg, ascorbic acid 78.7 mg/kg, tocopherol 7.9 mg/kg, and carnitine 65.6 mg/kg) was initiated. He had an episode of acute bronchitis at 4 months and febrile status epilepticus at 10 months, but there was no evidence of elevated lactic acid and pyruvate or transaminases at either of these times. His electroencephalogram was normal, and phenobarbital suppository was initiated when he developed fever. As the clinical course and MRI images were suggestive of BBGD, biotin 10–15 mg/kg/day was initiated at this time in addition to an increased dosage of thiamine 10–20 mg/kg/day, and no recurrence of encephalopathy or other crisis occurred. After initiating biotin and thiamine, he gradually gained eye tracking and smiling and developed shyness. After obtaining informed consent, target sequencing was performed for the patient using a modified version of a previously described method 4 . Briefly, indexed genomic DNA (gDNA) libraries were prepared from gDNA of the patient’s blood, and target regions, including 264 genes and the entire mitochondrial genome, were captured using SureSelect Custom Target DNA Enrichment kits (Agilent Technologies) in accordance with the manufacturer’s protocol; 150-bp paired-end read sequencing was performed using MiSeq (Illumina). We used Sanger sequencing to confirm the mutations identified and assess the carrier status of unaffected family members. PCR direct sequencing was performed using a BigDye v3.1 cycle sequencing kit (Thermo Fisher Scientific) and Genetic Analyzer. A compound heterozygous SLC19A3 mutation, NM_025243.4: [c.384_387del,p.Tyr128fs];[c.265A>C,p.Ser89Arg], was identified in the patient. A novel truncating mutation [c.384_387del,p.Tyr128fs] inherited from the mother appears to be pathogenic. A variant [c.265A>C,p.Ser89Arg] inherited from the father is likely pathogenic because it has already been reported in four cases 3 , 5 , 6 ; it is predicted to be deleterious/damaging by 4 of 5 variant prediction programs (Supplementary Table 1 ). We classified the variants according to the ACMG_AMP classification guideline 7 . [c.384_387del,p.Tyr128fs] is thought to be pathogenic in PVS1 (the variant is thought to cause early truncation resulting in loss of function), PM2 (extremely low frequency), and PP4 (not been reported, but the phenotype of the compound mutations with other clinical BBGD cases is very specific). [c.265A>C,p. Ser89Arg] is likely pathogenic in PM2 , PM3 (the other allele is thought to cause early truncation resulting in loss of function, and the phenotype is thought to be a recessive disorder), PP3 (multiple lines of computational evidence of a deleterious effect of the variant are provided in Supplementary Table 1 ), and PP4 (reported in four cases with LS or BBGD 3 , 5 , 6 , clinically specific phenotypes for the gene). Sanger sequencing for the parents and patient confirmed the mutations identified . We did not find any SNPs that account for the developmental delay, only the SLC19A3 aberration. The patient’s follow-up brain MRI showed high-intensity signals in the bilateral thalamus, liquefaction of the dorsal putamen, and atrophy in the cortex, subcortical white matter, and white matter as sequelae of neonatal encephalopathy . The patient now smiles and follows objects with his eyes. However, he displays severe intellectual disability without the ability to form words. His muscle tone is hypotonic, and tendon reflexes are elevated with a positive Babinski sign. The patient cannot hold his head or roll over. Due to swallowing difficulty, he is fed by gastrostomy. Fig. 1 The patient’s magnetic resonance images. a , b Acute-phase brain MRI showed high-intensity signals in the bilateral thalamus, putamen and globus pallidus. c , d Follow-up brain MRI showed high-intensity signals in the bilateral thalamus, liquefaction of the dorsal putamen, and atrophy in the cortex, subcortical white matter, and white matter as sequelae of neonatal encephalopathy.
| 4.261719
| 0.929688
|
sec[0]/p[2]
|
en
| 0.999998
|
36175418
|
https://doi.org/10.1038/s41439-022-00210-z
|
[
"acid",
"sequencing",
"brain",
"intensity",
"signals",
"thalamus",
"putamen",
"encephalopathy",
"lactate",
"using"
] |
[
{
"code": "5C73.Z",
"title": "Acidosis, unspecified"
},
{
"code": "DA22.Z",
"title": "Gastro-oesophageal reflux disease, unspecified"
},
{
"code": "DA41.2",
"title": "Acid hypersecretion"
},
{
"code": "5B5C.Z",
"title": "Vitamin B3 deficiency, unspecified"
},
{
"code": "5C64.3",
"title": "Disorders of phosphorus metabolism or phosphatases"
},
{
"code": "LB73.10",
"title": "Poland syndrome"
},
{
"code": "LD44.N0",
"title": "CATCH 22 phenotype"
},
{
"code": "LB31.3",
"title": "Exstrophy of urinary bladder"
},
{
"code": "LD2F.1Y",
"title": "Other specified syndromes with multiple structural anomalies, not of environmental origin"
},
{
"code": "LA56",
"title": "Pierre Robin syndrome"
}
] |
=== ICD-11 CODES FOUND ===
[5C73.Z] Acidosis, unspecified
Also known as: Acidosis, unspecified | Acidosis | acidosis NOS | metabolic acidaemia | lactic acidosis
[DA22.Z] Gastro-oesophageal reflux disease, unspecified
Also known as: Gastro-oesophageal reflux disease, unspecified | Gastro-oesophageal reflux disease | GORD - [gastro-oesophageal reflux disease] | gastroesophageal reflux disease | acid reflux disease
[DA41.2] Acid hypersecretion
Definition: Acid hypersecretion is a condition due to basal hypersecretion of gastric acid in the stomach, resulting in peptic ulcer and steatorrhoea.
Also known as: Acid hypersecretion | acid peptic disease
Excludes: Zollinger-Ellison syndrome
[5B5C.Z] Vitamin B3 deficiency, unspecified
Also known as: Vitamin B3 deficiency, unspecified | Vitamin B3 deficiency | nicotinic acid deficiency | vitamin B3 deficiency NOS | deficiency of niacin-tryptophan
[5C64.3] Disorders of phosphorus metabolism or phosphatases
Definition: Any condition caused by errors in phosphorus metabolism, or in phosphatase activity.
Also known as: Disorders of phosphorus metabolism or phosphatases | disorders of phosphorus metabolism | Hypophosphatasia | Rathbun syndrome | Congenital hypophosphatasia
Includes: Hypophosphatasia
Excludes: Adult osteomalacia | Osteoporosis
[LB73.10] Poland syndrome
Definition: Poland syndrome is characterised by a unilateral absence or hypoplasia of the pectoralis major muscle (most frequently involving the sternocostal portion), and a variable degree of ipsilateral hand anomalies, including symbrachydactyly.
Also known as: Poland syndrome | Poland sequence | Poland anomaly
[LD44.N0] CATCH 22 phenotype
Definition: Monosomy 22q11 (DiGeorge Velocardiofacial syndrome, DGS/VCF) syndrome is a chromosomal anomaly characterised by the association of several variable malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal heart defects, a subtle but characteristic facial dysmorphism, cleft palate or velar insufficiency, and learning difficulties.
Also known as: CATCH 22 phenotype | Conotruncal anomalies face syndrome | Velocardiofacial syndrome | Shprintzen syndrome | Sedlackova syndrome
Includes: Pharyngeal pouch syndrome | DiGeorge syndrome | Velocardiofacial syndrome
[LB31.3] Exstrophy of urinary bladder
Definition: Bladder exstrophy (or classic bladder exstrophy) is a congenital genitourinary malformation belonging to the spectrum of the exstrophy-epispadias complex and is characterised by an evaginated bladder plate, epispadias and an anterior defect of the pelvis, pelvic floor and abdominal wall.
Also known as: Exstrophy of urinary bladder | Ectopia vesicae | Extroversion of bladder | bladder ectopia | congenital ectopic bladder
Includes: Ectopia vesicae | Extroversion of bladder
[LD2F.1Y] Other specified syndromes with multiple structural anomalies, not of environmental origin
Also known as: Other specified syndromes with multiple structural anomalies, not of environmental origin | 46,XX disorder of sex development - anorectal anomalies | 46,XX DSD - anorectal anomalies | Aarskog-Scott syndrome | Aarskog syndrome
[LA56] Pierre Robin syndrome
Definition: Pierre-Robin syndrome (or Pierre-Robin sequence) is characterised by triad of orofacial morphological anomalies consisting of retrognathism, glossoptosis and a posterior median velopalatal cleft. This condition is referred to as a sequence because the posterior cleft palate is a secondary defect associated with abnormal mandibular development: mandibular hypoplasia occurring early in gestation causes the tongue to be maintained high-up in the oral cavity, preventing fusion of the palatal shelves
Also known as: Pierre Robin syndrome | Pierre Robin sequence
=== GRAPH WALKS ===
--- Walk 1 ---
[5C73.Z] Acidosis, unspecified
--PARENT--> [5C73] Acidosis
Def: Acidosis is an abnormally acidic state of the blood and tissues....
--EXCLUDES--> [?] Diabetes mellitus
Def: A metabolic disorder with heterogenous aetiologies which is characterised by chronic hyperglycaemia and disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secre...
--- Walk 2 ---
[5C73.Z] Acidosis, unspecified
--PARENT--> [5C73] Acidosis
Def: Acidosis is an abnormally acidic state of the blood and tissues....
--RELATED_TO--> [?] Kussmaul respiration
--- Walk 3 ---
[DA22.Z] Gastro-oesophageal reflux disease, unspecified
--PARENT--> [DA22] Gastro-oesophageal reflux disease
Def: A condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications...
--CHILD--> [DA22.1] Erosive gastro-oesophageal reflux disease
Def: Erosive gastro-oesophageal reflux disease is defined endoscopically by visible breaks of the distal oesophageal mucosa....
--- Walk 4 ---
[DA22.Z] Gastro-oesophageal reflux disease, unspecified
--PARENT--> [DA22] Gastro-oesophageal reflux disease
Def: A condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications...
--RELATED_TO--> [?] Gastro-oesophageal reflux disease in newborn
Def: A condition which develops when the reflux of stomach contents causes the newborn to vomit with associated discomfort, difficulty feeding and/or weight loss....
--- Walk 5 ---
[DA41.2] Acid hypersecretion
Def: Acid hypersecretion is a condition due to basal hypersecretion of gastric acid in the stomach, resulting in peptic ulcer and steatorrhoea....
--EXCLUDES--> [?] Zollinger-Ellison syndrome
Def: A syndrome characterised by the presence of a gastrin-secreting tumour, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms ...
--CHILD--> [?] Gastric ulcer due to Zollinger-Ellison syndrome
Def: Zollinger-Ellison syndrome is a rare cause of gastric ulcer secondary to gastric acid hypersecretion due to unregulated gastrin release from a non-? cell endocrine tumour (gastrinoma) of pancreas or d...
--- Walk 6 ---
[DA41.2] Acid hypersecretion
Def: Acid hypersecretion is a condition due to basal hypersecretion of gastric acid in the stomach, resulting in peptic ulcer and steatorrhoea....
--EXCLUDES--> [?] Zollinger-Ellison syndrome
Def: A syndrome characterised by the presence of a gastrin-secreting tumour, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms ...
--CHILD--> [?] Gastric ulcer due to Zollinger-Ellison syndrome
Def: Zollinger-Ellison syndrome is a rare cause of gastric ulcer secondary to gastric acid hypersecretion due to unregulated gastrin release from a non-? cell endocrine tumour (gastrinoma) of pancreas or d...
|
[
"[5C73.Z] Acidosis, unspecified\n --PARENT--> [5C73] Acidosis\n Def: Acidosis is an abnormally acidic state of the blood and tissues....\n --EXCLUDES--> [?] Diabetes mellitus\n Def: A metabolic disorder with heterogenous aetiologies which is characterised by chronic hyperglycaemia and disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secre...",
"[5C73.Z] Acidosis, unspecified\n --PARENT--> [5C73] Acidosis\n Def: Acidosis is an abnormally acidic state of the blood and tissues....\n --RELATED_TO--> [?] Kussmaul respiration",
"[DA22.Z] Gastro-oesophageal reflux disease, unspecified\n --PARENT--> [DA22] Gastro-oesophageal reflux disease\n Def: A condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications...\n --CHILD--> [DA22.1] Erosive gastro-oesophageal reflux disease\n Def: Erosive gastro-oesophageal reflux disease is defined endoscopically by visible breaks of the distal oesophageal mucosa....",
"[DA22.Z] Gastro-oesophageal reflux disease, unspecified\n --PARENT--> [DA22] Gastro-oesophageal reflux disease\n Def: A condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications...\n --RELATED_TO--> [?] Gastro-oesophageal reflux disease in newborn\n Def: A condition which develops when the reflux of stomach contents causes the newborn to vomit with associated discomfort, difficulty feeding and/or weight loss....",
"[DA41.2] Acid hypersecretion\n Def: Acid hypersecretion is a condition due to basal hypersecretion of gastric acid in the stomach, resulting in peptic ulcer and steatorrhoea....\n --EXCLUDES--> [?] Zollinger-Ellison syndrome\n Def: A syndrome characterised by the presence of a gastrin-secreting tumour, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms ...\n --CHILD--> [?] Gastric ulcer due to Zollinger-Ellison syndrome\n Def: Zollinger-Ellison syndrome is a rare cause of gastric ulcer secondary to gastric acid hypersecretion due to unregulated gastrin release from a non-? cell endocrine tumour (gastrinoma) of pancreas or d...",
"[DA41.2] Acid hypersecretion\n Def: Acid hypersecretion is a condition due to basal hypersecretion of gastric acid in the stomach, resulting in peptic ulcer and steatorrhoea....\n --EXCLUDES--> [?] Zollinger-Ellison syndrome\n Def: A syndrome characterised by the presence of a gastrin-secreting tumour, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms ...\n --CHILD--> [?] Gastric ulcer due to Zollinger-Ellison syndrome\n Def: Zollinger-Ellison syndrome is a rare cause of gastric ulcer secondary to gastric acid hypersecretion due to unregulated gastrin release from a non-? cell endocrine tumour (gastrinoma) of pancreas or d..."
] |
5C73.Z
|
Acidosis, unspecified
|
[
{
"from_icd11": "5C73.Z",
"icd10_code": "E872",
"icd10_title": "Acidosis"
},
{
"from_icd11": "DA22.Z",
"icd10_code": "K219",
"icd10_title": "Gastro-esophageal reflux disease without esophagitis"
},
{
"from_icd11": "DA22.Z",
"icd10_code": "K210",
"icd10_title": "Gastro-esophageal reflux disease with esophagitis"
},
{
"from_icd11": "DA22.Z",
"icd10_code": "K21",
"icd10_title": "Gastro-esophageal reflux disease"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K31819",
"icd10_title": "Angiodysplasia of stomach and duodenum without bleeding"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K31811",
"icd10_title": "Angiodysplasia of stomach and duodenum with bleeding"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K3189",
"icd10_title": "Other diseases of stomach and duodenum"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K3182",
"icd10_title": "Dieulafoy lesion (hemorrhagic) of stomach and duodenum"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K3183",
"icd10_title": "Achlorhydria"
},
{
"from_icd11": "DA41.2",
"icd10_code": "K318",
"icd10_title": "Other specified diseases of stomach and duodenum"
},
{
"from_icd11": "5C64.3",
"icd10_code": "E8339",
"icd10_title": "Other disorders of phosphorus metabolism"
},
{
"from_icd11": "5C64.3",
"icd10_code": "E8332",
"icd10_title": "Hereditary vitamin D-dependent rickets (type 1) (type 2)"
},
{
"from_icd11": "5C64.3",
"icd10_code": "E8331",
"icd10_title": "Familial hypophosphatemia"
},
{
"from_icd11": "5C64.3",
"icd10_code": "E8330",
"icd10_title": "Disorder of phosphorus metabolism, unspecified"
},
{
"from_icd11": "5C64.3",
"icd10_code": "E833",
"icd10_title": "Disorders of phosphorus metabolism and phosphatases"
}
] |
E872
|
Acidosis
|
In 2007, a 32-year-old male patient was being worked up for a potential sinus surgery and was found to have a right sided neck mass. He underwent a surgical resection with histologic confirmation of a paraganglioma. Prior to his surgery he had no clinical evidence of catecholamine excess. In 2011, the patient underwent a scheduled surgery on his ankle which was complicated by a hypertensive crisis. He was found to have elevated plasma metanephrines and urinary catecholamines. On imaging work up, he was found to have a tumor involving his aorta originating from the organ of Zuckerkandl. After being started on phenoxybenzamine, he underwent surgery with resection of this tumor. In 2012, he was evaluated by a geneticist and reported no family history of malignancy. Genetic testing for SDHB, SHDC , and SDHD gene mutations by aCGH (ExonArrayDx) did not detect any disease-associated mutations in exons 1-8 of the SDHB gene, exons 1-6 of the SDHC gene, exons 1-4 of the SDHD gene, or the c.232 G>A in exon 3 of the SDHAF2 gene (required for flavination of the SDHA subunit). He did not have detected mutations in the von Hippel-Lindau ( VHL ) SDHA , and Fumarase ( FH ) genes. In 2014 he suffered a transient ischemic attack with left-sided weakness that self-resolved within 24 h. At that time, his blood pressure was minimally elevated with systolic blood pressure in the 140–150 mm Hg range. In 2015, he was diagnosed with multiple metastatic lymph nodes involving his retroperitoneum encasing his left ureter. He again underwent surgical resection with eventual ureteral stent placement. In late 2015, he was found to have a metastatic tumor involving the caudate lobe of his liver for which he underwent trans-catheter arterial chemoembolization. In 2016, he underwent an octreotide nuclear scan of his abdomen. He was found to have a new metastatic lesion involving his sacrum and a left-sided skull-based lesion. In addition, a new retroperitoneal lesion was identified and the lesion involving the caudate lobe of the liver remained stable. The tumors showed I 131 -MIBG uptake. In 2016, he had resection of his caudate lobe and resection of the pre-aortic tumor. Soon after he was found to have disease progression in a para-aortic lymph node and within multiple bony lesions including his calvarium, thoracic spine, rib cage, and sacrum. He was enrolled in a clinical trial and received cabozantinib 60 mg by mouth daily on protocol. The patient was on study for 7.5 months prior to developing progressive disease in multiple known and new bone metastases, development of a new pulmonary metastasis, and progression of his known retroperitoneal lymph nodes. In 2017, the patient enrolled on a basket clinical trial with pembrolizumab and received 200 mg intravenously every 3 weeks for 5 months prior to experiencing disease progression in retroperitoneal and pelvic lymph nodes, new soft tissue metastasis within the abdomen, additional lung metastasis, and progression of multiple bone metastasis including the development of a new femoral lesion. His best response on the study was considered stable disease. He then received three cycles of cyclophosphamide, vincristine, and dacarbazine. His treatment course was complicated by severe myelosuppression. He required admission for neutropenic fever and received multiple transfusions of both packed red blood cells and platelets. With chemotherapy he had evidence of disease response with a 12.2% reduction in his measurable disease with stability in his bone metastasis. However, within 3 months of ending chemotherapy he had progressive pain in his back and was found to have progression of disease in vertebral column bone metastases. A timeline of his systemic treatment is provided in Figure 1 . The patient was started on off label cabozantinib and nivolumab. Cabozantinib was dosed at 40 mg by mouth daily and nivolumab was provided at 240 mg IV every 2 weeks as per the phase I study by Apolo et al. ( 19 ) Figure 2 contrasts his baseline imaging studies with the ones obtained 18 months after treatment initiation. The patient’s course was complicated by several events including ulcerations on his lower extremities shown in Figure 3 . A biopsy of these ulcerations found evidence of mild epithelial spongiosis with focal parakeratosis. There was evidence of a superficial perivascular lymphocytic infiltrate with scattered eosinophils. The dermatopathology group at MD Anderson Cancer Center determined these findings were most consistent with a hypersensitivity reaction to an internal medication. Breaks from cabozantinib allowed these ulcerations to heal. At present the patient remains on this regimen 22 months after initiation with evidence of continued clinical benefit. He had significant tumor reduction with decrease in size of lung, abdominal, bone and retroperitoneal lesions. On treatment his plasma metanephrines decreased from a baseline level of 14 nmol/L to 3.6 nmol/L. In addition, the patient symptomatically improved without signs of catecholamine excess and his blood pressure remains very well controlled after being started on both alpha and beta blockers.
| 4.027344
| 0.977051
|
sec[1]/p[0]
|
en
| 0.999996
|
33329398
|
https://doi.org/10.3389/fendo.2020.594264
|
[
"resection",
"evidence",
"tumor",
"involving",
"gene",
"multiple",
"lesion",
"progression",
"bone",
"metastasis"
] |
[
{
"code": "QA04.Y",
"title": "Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes"
},
{
"code": "JB07.Z",
"title": "Labour or delivery complicated by fetal distress, unspecified"
},
{
"code": "MA14.0",
"title": "Laboratory evidence of human immunodeficiency virus"
},
{
"code": "2C64",
"title": "Solid papillary carcinoma of breast with evidence of invasion"
},
{
"code": "JB07.2",
"title": "Labour or delivery complicated by biochemical evidence of fetal stress"
},
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
}
] |
=== ICD-11 CODES FOUND ===
[QA04.Y] Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes
Also known as: Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes | Examination and observation following other inflicted injury | Examination of victim or culprit following other inflicted injury | Observation for concussion | Request for expert evidence
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
Also known as: Labour or delivery complicated by fetal distress, unspecified | Labour or delivery complicated by fetal distress | Labour and delivery complicated by fetal stress | fetal distress affecting labour and delivery | Electrocardiographic evidence of fetal distress
[MA14.0] Laboratory evidence of human immunodeficiency virus
Also known as: Laboratory evidence of human immunodeficiency virus | human immunodeficiency virus test positive | positive test for HIV | laboratory evidence of HIV | Nonconclusive HIV-test finding in infants
Excludes: Human immunodeficiency disease complicating pregnancy, childbirth or the puerperium | Human immunodeficiency virus disease | Asymptomatic human immunodeficiency virus infection
[2C64] Solid papillary carcinoma of breast with evidence of invasion
Also known as: Solid papillary carcinoma of breast with evidence of invasion
[JB07.2] Labour or delivery complicated by biochemical evidence of fetal stress
Definition: A condition characterised by complications during labour and delivery that is caused by biochemical evidence of fetal distress. Confirmation is by a fetal blood sample from a scalp prick through the open cervix during labour.
Also known as: Labour or delivery complicated by biochemical evidence of fetal stress | Labour or delivery complicated by abnormal fetal acid-base balance | Labour or delivery complicated by abnormal fetal acidaemia
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[QA04.Y] Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes
--PARENT--> [QA04] Examination or observation for reasons other than suspected diseases or conditions or administrative purposes
--CHILD--> [QA04.1] Alcohol and drug testing other than by blood
--- Walk 2 ---
[QA04.Y] Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes
--PARENT--> [QA04] Examination or observation for reasons other than suspected diseases or conditions or administrative purposes
--CHILD--> [QA04.0] Blood-alcohol or blood-drug test
--- Walk 3 ---
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
--PARENT--> [JB07] Labour or delivery complicated by fetal distress
--CHILD--> [JB07.1] Labour or delivery complicated by meconium in amniotic fluid
Def: A condition characterised by complications during labour and delivery that is caused by meconium in amniotic fluid....
--- Walk 4 ---
[JB07.Z] Labour or delivery complicated by fetal distress, unspecified
--PARENT--> [JB07] Labour or delivery complicated by fetal distress
--PARENT--> [?] Complications of labour or delivery
Def: Any complication characterised by the adverse evolution of a condition that arises during any one of the three stages of labour and delivery....
--- Walk 5 ---
[MA14.0] Laboratory evidence of human immunodeficiency virus
--EXCLUDES--> [?] Asymptomatic human immunodeficiency virus infection
Def: A condition caused by an infection with human immunodeficiency virus. This condition is characterised by fever, swollen lymph nodes, sore throat, or rash. This condition may also present with headache...
--EXCLUDES--> [?] Contact with or exposure to human immunodeficiency virus
--- Walk 6 ---
[MA14.0] Laboratory evidence of human immunodeficiency virus
--EXCLUDES--> [?] Human immunodeficiency disease complicating pregnancy, childbirth or the puerperium
--PARENT--> [?] Maternal infectious diseases classifiable elsewhere but complicating pregnancy, childbirth or the puerperium
Def: Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth or the puerperium...
|
[
"[QA04.Y] Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes\n --PARENT--> [QA04] Examination or observation for reasons other than suspected diseases or conditions or administrative purposes\n --CHILD--> [QA04.1] Alcohol and drug testing other than by blood",
"[QA04.Y] Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes\n --PARENT--> [QA04] Examination or observation for reasons other than suspected diseases or conditions or administrative purposes\n --CHILD--> [QA04.0] Blood-alcohol or blood-drug test",
"[JB07.Z] Labour or delivery complicated by fetal distress, unspecified\n --PARENT--> [JB07] Labour or delivery complicated by fetal distress\n --CHILD--> [JB07.1] Labour or delivery complicated by meconium in amniotic fluid\n Def: A condition characterised by complications during labour and delivery that is caused by meconium in amniotic fluid....",
"[JB07.Z] Labour or delivery complicated by fetal distress, unspecified\n --PARENT--> [JB07] Labour or delivery complicated by fetal distress\n --PARENT--> [?] Complications of labour or delivery\n Def: Any complication characterised by the adverse evolution of a condition that arises during any one of the three stages of labour and delivery....",
"[MA14.0] Laboratory evidence of human immunodeficiency virus\n --EXCLUDES--> [?] Asymptomatic human immunodeficiency virus infection\n Def: A condition caused by an infection with human immunodeficiency virus. This condition is characterised by fever, swollen lymph nodes, sore throat, or rash. This condition may also present with headache...\n --EXCLUDES--> [?] Contact with or exposure to human immunodeficiency virus",
"[MA14.0] Laboratory evidence of human immunodeficiency virus\n --EXCLUDES--> [?] Human immunodeficiency disease complicating pregnancy, childbirth or the puerperium\n --PARENT--> [?] Maternal infectious diseases classifiable elsewhere but complicating pregnancy, childbirth or the puerperium\n Def: Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth or the puerperium..."
] |
QA04.Y
|
Other specified examination or observation for reasons other than suspected diseases or conditions or administrative purposes
|
[
{
"from_icd11": "JB07.Z",
"icd10_code": "O68",
"icd10_title": "Labor and delivery complicated by abnormality of fetal acid-base balance"
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O682",
"icd10_title": ""
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O688",
"icd10_title": ""
},
{
"from_icd11": "JB07.Z",
"icd10_code": "O689",
"icd10_title": ""
},
{
"from_icd11": "MA14.0",
"icd10_code": "R75",
"icd10_title": "Inconclusive laboratory evidence of human immunodeficiency virus [HIV]"
},
{
"from_icd11": "JB07.2",
"icd10_code": "O683",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2242",
"icd10_title": "Localized swelling, mass and lump, left lower limb"
}
] |
O68
|
Labor and delivery complicated by abnormality of fetal acid-base balance
|
According to a review of the literature (shown in Table 1 ), leiomyosarcoma is a rare and aggressive soft tissue tumor, originating from smooth muscle cells, which tends to occur in the alimentary tract, uterus, and retroperitoneum. Only 3% of leiomyosarcoma cases occur in the head and neck regions . The most common sites in the sinonasal tract include the maxillary sinus, nasal cavity and ethmoid sinuses . Leiomyosarcoma of the sinonasal tract may originate from the smooth muscles of blood vessels, which are the only structures containing smooth muscles in the area . Our patient was diagnosed with leiomyosarcoma in the left maxillary sinus, which is a rare observation. Generally, the treatment of leiomyosarcoma poses a challenge due to the high rate of recurrence and metastasis and poor prognosis. Our patient was 24 years old, which is the most common age for leiomyosarcoma with the age range of 21-73 years . Leiomyosarcoma of soft tissue commonly presents as a slow-growing painless mass, which can cause a variety of symptoms, depending on its location . Previous studies have reported leiomyosarcoma as a large soft tissue mass , which can invade the maxillary walls and cause obstruction and destruction . The common presentations in the maxillofacial region include nasal obstruction, epistaxis, local pain, and facial swelling. Patients initially notice facial swelling with stretched skin ; long-term rhinorrhea is also possible . In cases where the tumor invades the orbit, eye movements may be restricted . The oral mucosa may remain normal or become erythematous, similar to our case, who reported oral lesions in the left maxilla five months before diagnosis . Our patient had undergone a nasal polyp surgery one year before diagnosis, which could be a primary manifestation of the tumor, though without any related findings at that time. When leiomyosarcoma is suspected, a CT scan should be requested in the first step. Usually, it presents as a bulky lesion that can remodel the bone and shows mild to moderate enhancement. In addition, it commonly shows extensive necrotic or cystic changes and does not show calcification . The imaging of our patient had all these features and showed mucosal thickening in the left maxillary sinus. In this regard, Taghipour et al. reported mucosal thickening of the left maxillary sinus. In our patient, the MRI showed intermediate to high signals on the T2-weighted image, but intermediate signals on the T1-weighted image, which could be attributed to the surrounding fat and indicative of lymphadenopathy . Differential diagnoses, based on all findings were a list of undifferentiated pleomorphic sarcoma, rhabdomyosarcoma, leiomyosarcoma, malignant peripheral nerve sheath tumor, fibrosarcoma, synovial sarcoma, sarcomatoid carcinoma, metastatic lesions, and fungal infections . To confirm the diagnosis of the lesion, an incisional biopsy was taken. The results of the biopsy showed spindle-shaped cells with oval to elongated nuclei, mitosis, hyalinization, necrosis, eosinophilic cytoplasm, and inflammatory infiltration . In our case, the IHC analysis of the specimen showed vimentin, SMA and desmin staining , indicative of leiomyosarcoma. The gross pathology of leiomyosarcoma indicated a firm reddish-brown appearance on the surface and a solid yellowish-white fibrous cut surface with hemorrhage and necrosis ; a grayish color was also observed . Moreover, the pathological features were consistent with the biopsy results . Studies of maxillofacial leiomyosarcoma show poor prognosis and a high recurrence rate . Overall, surgical treatment with clear margins is recommended to control the recurrence of leiomyosarcoma . The risk of recurrence is higher in maxillary leiomyosarcoma with a poorer prognosis, because of difficult access to some anatomical sites and free margins . Overall, an accurate diagnosis and a proper combined treatment plan can produce favorable outcomes . Surgery, chemotherapy, and radiotherapy are treatment modalities of leiomyosarcoma, based on clinical and tumor features. Surgical excision seems to have the best outcomes, if the tumor could be removed completely. Leiomyosarcoma is generally considered radio resistant, but the benefits of radiotherapy have been also reported. Chemotherapy is often used for metastatic lesions, as well as inoperable tumors as a palliative therapy . In cases where tumor invasion is not extensive, chemotherapy may be the first-line of treatment. In this regard, Zahir et al. used three courses of chemotherapy, including Adriamycin (35mg) plus normal saline (100cc) for three days; intravenous injection of Ifosfamide (350mg) plus n ormal saline (500cc) for three days; and intravenous injection of Mesna (400, 800 and 800 at 0, 4, and 8 hours, respectively) for three consecutive days, along w ith intravenous injection of dacarbazine (500 mg) plus normal saline (500 cc) for three consecutive days. In addition, Nishi et al. administered 8-10 mg/ day of Adriamycin for four days, along with cyclophosphamide. However, in their study, the patient failed to respond to treatment, and radiotherapy was administered.
| 4.257813
| 0.461914
|
sec[2]/p[0]
|
en
| 0.999998
|
36380835
|
https://doi.org/10.30476/DENTJODS.2021.89153.1398
|
[
"leiomyosarcoma",
"which",
"tumor",
"maxillary",
"three",
"sinus",
"recurrence",
"chemotherapy",
"soft",
"tissue"
] |
[
{
"code": "2B58.Y",
"title": "Leiomyosarcoma, other specified primary site"
},
{
"code": "2B58.1",
"title": "Leiomyosarcoma of uterus"
},
{
"code": "2B58.Y&XA0828",
"title": "Leiomyosarcoma of oesophagus"
},
{
"code": "2B58.2",
"title": "Leiomyosarcoma of stomach"
},
{
"code": "2C6Y",
"title": "Other specified malignant neoplasms of breast"
},
{
"code": "BD50.41",
"title": "Abdominal aortic aneurysm with rupture"
},
{
"code": "EK91",
"title": "Dermatoses which may presage cutaneous lymphoma"
},
{
"code": "MH12.1",
"title": "Death occurring less than 24 hours from onset of symptoms, not otherwise explained"
},
{
"code": "8A44.3",
"title": "Certain specified leukodystrophies"
},
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
}
] |
=== ICD-11 CODES FOUND ===
[2B58.Y] Leiomyosarcoma, other specified primary site
Also known as: Leiomyosarcoma, other specified primary site | Leiomyosarcoma of oesophagus | Leiomyosarcoma of duodenum | Small intestinal leiomyosarcoma | Cutaneous leiomyosarcoma
[2B58.1] Leiomyosarcoma of uterus
Also known as: Leiomyosarcoma of uterus | uterine leiomyosarcoma | Leiomyosarcoma of cervix uteri
[2B58.2] Leiomyosarcoma of stomach
Definition: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle.
Also known as: Leiomyosarcoma of stomach
[2C6Y] Other specified malignant neoplasms of breast
Also known as: Other specified malignant neoplasms of breast | Metaplastic carcinoma of breast | Hereditary breast cancer | Paget disease of breast | areola cancer
[BD50.41] Abdominal aortic aneurysm with rupture
Also known as: Abdominal aortic aneurysm with rupture | abdominal aorta aneurysm rupture | abdominal aorta aneurysm ruptured | abdominal aortic aneurysm which has ruptured | ruptured AAA
[EK91] Dermatoses which may presage cutaneous lymphoma
Definition: Dermatoses which may represent the earliest stages of cutaneous lymphoma but where it is not possible to confirm their neoplastic nature.
Also known as: Dermatoses which may presage cutaneous lymphoma
[MH12.1] Death occurring less than 24 hours from onset of symptoms, not otherwise explained
Also known as: Death occurring less than 24 hours from onset of symptoms, not otherwise explained | died without sign of disease | Death known not to be violent or instantaneous for which no cause can be discovered | death known not to be violent or instantaneous, cause unknown | Death without sign of disease
Includes: Death known not to be violent or instantaneous for which no cause can be discovered | Death without sign of disease
[8A44.3] Certain specified leukodystrophies
Also known as: Certain specified leukodystrophies | CACH syndrome | Vanishing white matter disease | Childhood ataxia with central nervous system hypomyelination | Congenital or early infantile CACH syndrome
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
=== GRAPH WALKS ===
--- Walk 1 ---
[2B58.Y] Leiomyosarcoma, other specified primary site
--PARENT--> [2B58] Leiomyosarcoma, primary site
--PARENT--> [?] Malignant mesenchymal neoplasms
Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...
--- Walk 2 ---
[2B58.Y] Leiomyosarcoma, other specified primary site
--PARENT--> [2B58] Leiomyosarcoma, primary site
--CHILD--> [2B58.0] Leiomyosarcoma of retroperitoneum or peritoneum
--- Walk 3 ---
[2B58.1] Leiomyosarcoma of uterus
--PARENT--> [2B58] Leiomyosarcoma, primary site
--PARENT--> [?] Malignant mesenchymal neoplasms
Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...
--- Walk 4 ---
[2B58.1] Leiomyosarcoma of uterus
--PARENT--> [2B58] Leiomyosarcoma, primary site
--CHILD--> [2B58.2] Leiomyosarcoma of stomach
Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....
--- Walk 5 ---
[2B58.2] Leiomyosarcoma of stomach
Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....
--PARENT--> [2B58] Leiomyosarcoma, primary site
--CHILD--> [2B58.2] Leiomyosarcoma of stomach
Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....
--- Walk 6 ---
[2B58.2] Leiomyosarcoma of stomach
Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....
--PARENT--> [2B58] Leiomyosarcoma, primary site
--CHILD--> [2B58.1] Leiomyosarcoma of uterus
|
[
"[2B58.Y] Leiomyosarcoma, other specified primary site\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --PARENT--> [?] Malignant mesenchymal neoplasms\n Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...",
"[2B58.Y] Leiomyosarcoma, other specified primary site\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --CHILD--> [2B58.0] Leiomyosarcoma of retroperitoneum or peritoneum",
"[2B58.1] Leiomyosarcoma of uterus\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --PARENT--> [?] Malignant mesenchymal neoplasms\n Def: A usually aggressive malignant mesenchymal cell tumour most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The progn...",
"[2B58.1] Leiomyosarcoma of uterus\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --CHILD--> [2B58.2] Leiomyosarcoma of stomach\n Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....",
"[2B58.2] Leiomyosarcoma of stomach\n Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --CHILD--> [2B58.2] Leiomyosarcoma of stomach\n Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....",
"[2B58.2] Leiomyosarcoma of stomach\n Def: This is a malignant nonepithelial tumour that arises from cells lining the stomach that develop into smooth-muscle....\n --PARENT--> [2B58] Leiomyosarcoma, primary site\n --CHILD--> [2B58.1] Leiomyosarcoma of uterus"
] |
2B58.Y
|
Leiomyosarcoma, other specified primary site
|
[
{
"from_icd11": "BD50.41",
"icd10_code": "I713",
"icd10_title": "Abdominal aortic aneurysm, ruptured"
},
{
"from_icd11": "EK91",
"icd10_code": "L989",
"icd10_title": "Disorder of the skin and subcutaneous tissue, unspecified"
},
{
"from_icd11": "MH12.1",
"icd10_code": "R961",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
}
] |
I713
|
Abdominal aortic aneurysm, ruptured
|
A Korean male infant with a weight of 1760 g (81st percentile) was born to a 22-year-old primigravid woman at 30 +4 weeks’ gestation via an emergency cesarean section delivery due to fetal distress with 2-day duration of premature rupture of the membranes (PROM). The mother was diagnosed with clinical chorioamnionitis based on the clinical findings at admission: a body temperature of 38.4 °C, a total white blood cell (WBC) count of 23,220 cells/mm 3 with 89% polymorphonuclear leukocytes, a heart rate of 129 beats/min, uterine fundal tenderness, and foul odor of the amniotic fluid. The mother had received no antenatal care including rectovaginal GBS screening and antepartum antibiotic administration without other particular medical history. Apgar scores were 4 and 7 at 1 and 5 minutes after birth, respectively. At birth, the infant presented with no initial crying, depressed muscle tone, and a heart rate of <100 beats/min, improved with resuscitation with positive pressure ventilation. Because of poor respiratory effort, the infant received ventilator support for 3 days with an episode of respiratory distress syndrome ameliorated by administrating a single dose of exogenous surfactant. The infant's body temperature was 36.9 °C. Empiric antimicrobial therapy with parenteral ampicillin (200 mg/kg/d) and gentamicin (4.5 mg/kg/36 h) was initiated for suspected perinatally acquired sepsis. The cord blood culture showed rapid growth of Gram-positive cocci in chains at 8 hours incubation, identified as S agalactiae at 48 hours. The mother developed postoperative surgical site infection with pelvic abscesses. Cultures from the maternal surgical wound and abscesses 2 days postpartum revealed GBS. Table 1 shows the flow of the infant's laboratory and clinical data. Initial cultures of the infant's blood, nasal mucosa, gastric aspirate, rectum and axilla specimens all grew GBS, and the urine culture was sterile. Initial laboratory evaluation demonstrated elevated C-reactive protein (CRP, 1.05 vs control <0.3 mg/dL). Blood culture repeated after 48 hours of antimicrobial administration was sterile. On postnatal day 5, gentamicin was discontinued. Ampicillin was ceased on day 15. On day 24, it was noted that the nasal mucosal swab culture performed 7 days after cessation of antibiotic administration yielded GBS. However, oral rifampicin as a decolonization therapy was not considered. On day 28 (13 days after completion of the first course of antibiotic therapy), respiratory distress was noted with apnea, a heart rate of 70 beats/min, and oxygen saturation 60% on room air. Cultures from blood and urine were obtained. The infant was afebrile (37.2 °C). The WBC count was 8140 cells/mm 3 with 16% segmented neutrophils and 71% lymphocytes. The CRP level was initially negative (<0.03 mg/dL), however, 2 days later the positive conversion (3.93 mg/dL) was observed. Initial broad-spectrum antimicrobial therapy consisted of 5 days of intravenous vancomycin, ampicillin, and gentamicin. Subsequent to antimicrobial therapy, the symptoms promptly resolved. The blood culture yielded GBS at 48 hours incubation and ampicillin was sustained for a total duration of 15 days. The urine culture was sterile. After 48 hours of antibiotic administration, repeat blood culture was sterile and cerebrospinal fluid (CSF) analysis and culture showed a WBC count of 1 cell/mm 3 , a protein level of 150 mg/dL, a glucose level of 39 mg/dL, and CSF sterility. Serial sonographic brain scanning on days 2, 16, 31, and 47 revealed progressive WMI consisting of bilateral periventricular echodensities evolving into focal cystic degeneration and bilateral asymmetric lateral ventriculomegaly, which was confirmed by brain magnetic resonance imaging on day 51 . Quantitative immunoglobulin profile was evaluated in the cord serum and the infant's serum on day 36; all the assessed levels of immunoglobulins G, A, and M were lower than the reference values established in similar-aged healthy infants. The Profile of T-, B-, and natural killer cell subset percentages on day 36 showed normal values. Complement profile was evaluated on day 42 of hemolytic complement activity, C3 and C4, of which all the serum levels were decreased compared with the reference values determined in sera of premature or term infants comparable in postnatal age. The infant's initial feeds comprised total parenteral nutrition, which maintained until day 13, and gavage feeds with preterm formula milk with no introduction to breastfeeding during the admission period. Oral feeding was added on day 14 and full oral feeding was achieved on day 37. Cultures from the infant's blood and nose and axilla swabs on days 36 and 49 were negative for GBS. Serological assays for toxoplasmosis, rubella, cytomegalovirus, herpes, and human immunodeficiency virus were negative. Abdominal ultrasound, echocardiography, and radiographic skeletal survey examination were normal. After the second set of GBS sepsis episodes, no further relapses have occurred. However, the infant was about 6 months delayed in motor development at 15 months of follow-up (12 months’ corrected age).
| 4.054688
| 0.975586
|
sec[2]/p[0]
|
en
| 0.999997
|
34160417
|
https://doi.org/10.1097/MD.0000000000026387
|
[
"blood",
"culture",
"hours",
"antibiotic",
"administration",
"antimicrobial",
"ampicillin",
"cultures",
"sterile",
"distress"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "QE00",
"title": "Acculturation difficulty"
},
{
"code": "MD40.51",
"title": "Positive sputum culture"
},
{
"code": "MD40.52",
"title": "Positive throat culture"
},
{
"code": "QE0Z",
"title": "Problems associated with social or cultural environment, unspecified"
},
{
"code": "MG65",
"title": "Abnormal microbiological findings in specimens from other organs, systems and tissues"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[QE00] Acculturation difficulty
Definition: Problems resulting from the inability to adjust to a different culture or environment.
Also known as: Acculturation difficulty | acculturation problem | cultural shock | social migrant difficulty | migration
Excludes: Disorders specifically associated with stress
[MD40.51] Positive sputum culture
Also known as: Positive sputum culture
[MD40.52] Positive throat culture
Also known as: Positive throat culture
[QE0Z] Problems associated with social or cultural environment, unspecified
Also known as: Problems associated with social or cultural environment, unspecified | social environment problem
[MG65] Abnormal microbiological findings in specimens from other organs, systems and tissues
Also known as: Abnormal microbiological findings in specimens from other organs, systems and tissues | positive wound culture | Positive culture findings on specimen from other organs, systems and tissue
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Diseases of the immune system
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--PARENT--> [MF50] Abnormal micturition
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Diseases of the immune system",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --PARENT--> [MF50] Abnormal micturition",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
A cyst is a clearly demarcated lesion consisting of an epithelial sac and can be divided into soft tissue and bone cysts, depending on the site of occurrence, with many occurring in the jawbone in the stomatognathic region. Odontogenic epithelium, which normally disappears during tooth eruption, causes cyst formation. The presence of salivary glands, which develop when the epithelium invaginates through the mesenchymal tissue, is also a factor in cyst development. According to the World Health Organization, dentigerous cysts are classified as developmental cysts, which are odontogenic among jawbone cysts. The treatment methods for cysts include fenestration, the Partch I method (marsupialization), the Partch II method (enucleation and primary closure), and open cyst removal (packed open method). The basic treatment is enucleation, however, if enlarged cysts are removed, the surgical intervention can become more invasive, giving rise to concerns about complications such as cortical bone disappearance , the cyst being in contact with the mandibular canal , or the risk of a pathological fracture. Furthermore, since it is desirable to preserve an adjacent impacted tooth, a two-step treatment may be performed in which fenestration is first performed, and the cyst cavity is then removed after it has shrunk . Fenestration is generally the treatment of choice for children and is considered useful because it preserves permanent teeth, is less invasive as a simpler procedure, and has a good prognosis . In this case, fenestration was chosen because of the patient's age, lesion size, and the goal of preserving the permanent teeth. After the fenestration of a cystic lesion, the gauze is typically replaced to prevent the extraction socket from closing. However, in this case, considering the burden of changing the dressing gauze for our minor patient, we practiced placing and removing the obturator before fenestration. Moreover, by using the device immediately after surgery under general anesthesia, we were able to replace the gauze after surgery. It is possible to maintain an open wound without the burden of replacement. Although the period of use of this obturator was short, it alleviated the burden on the patient. In addition, the ability to use the device as a retainer played an important role in securing the eruption space. Dentigerous cysts generally resemble radicular cysts in X-ray appearance, making it difficult to differentiate between them based on X-ray and clinical findings. Dentigerous cysts are caused by cyst formation in the enamel organ during tooth germ development. In contrast, radicular cysts are generally believed to arise when inflammation caused by pulp necrosis stimulates and proliferates the epithelial rests of Malassez. In the present case, a vitality test of the dental pulp was not performed before surgery. However, the mandibular left deciduous lateral incisor, which is suspected to be the cause of the cyst, did not exhibit signs of caries reaching the dental pulp . The CT image indicated that the lingual side of the root exhibited an irregular surface and signs of inflammatory root resorption, highly suggesting that it was a nonvital tooth . The cause of the pulp necrosis of the left mandibular deciduous lateral incisor is unknown. However, the tooth has been displaced to the labial side, suggesting a history of trauma or a worn-down incisal edge. Moreover, the CT image indicates that the pulp cavity has reached the incisal edge, suggesting pulp exposure . Pathological findings indicated inflammatory cell infiltration in the cyst wall, suggesting that the cyst was caused by an apical lesion of the left mandibular deciduous lateral incisor. Lustman and Shear outlined the following three conditions as diagnostic criteria for radicular cysts of deciduous teeth : (1) the presence of a nonvital deciduous tooth closely associated with a radiolucent lesion; (2) the presence of radicular cyst epithelium in the affected area; and (3) lack of a permanent tooth crown in the cyst cavity. In the present case, the deciduous anterior tooth, which was suspected to be the cause of the cyst, was highly likely to have been a nonvital tooth, as evidenced by the surgical findings indicating continuity between the cyst and the root of the deciduous tooth. Based on these findings, along with the histopathological findings, the diagnosis was a radicular cyst. The lesions are usually noticed by routine radiographic examination of primary teeth endodontic problems while some long-standing lesions may cause appreciable expansion of the cortical bone and display clinical signs and symptoms like swelling, tooth mobility, and displacement of a successful tooth. Radicular cysts often occur in association with endodontically treated primary teeth, so close follow-up is required after endodontic treatment. However, there are also cases where no endodontic treatment has been performed, as in this case, and no history of injury. In such cases, the lesion is discovered after some symptoms have developed, but it is necessary to diagnose and treat it promptly after the symptoms appear.
| 4.351563
| 0.504395
|
sec[2]/p[0]
|
en
| 0.999994
|
PMC11297190
|
https://doi.org/10.7759/cureus.63782
|
[
"cyst",
"cysts",
"tooth",
"deciduous",
"lesion",
"which",
"fenestration",
"radicular",
"pulp",
"however"
] |
[
{
"code": "FB80.5",
"title": "Solitary bone cyst"
},
{
"code": "EK70.Z",
"title": "Cutaneous cysts, unspecified"
},
{
"code": "FB4Y",
"title": "Other specified disorders of synovium or tendon"
},
{
"code": "CA0C",
"title": "Cyst or mucocele of nose or nasal sinus"
},
{
"code": "9A7Y",
"title": "Other specified disorders of the cornea"
},
{
"code": "DA07.6Y",
"title": "Other specified disturbances in tooth eruption"
},
{
"code": "LA30.0",
"title": "Anodontia"
},
{
"code": "QA00.8",
"title": "Dental examination"
},
{
"code": "LA30.3",
"title": "Hyperdontia"
},
{
"code": "DA0A.Y",
"title": "Other specified disorders of teeth and supporting structures"
}
] |
=== ICD-11 CODES FOUND ===
[FB80.5] Solitary bone cyst
Definition: A solitary bone cyst is a benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cases involving the jaw bone have been reported.
Also known as: Solitary bone cyst | cyst of bone | local cyst of bone | simple bone cyst | solitary bone cyst, unspecified site
Excludes: solitary cyst of jaw
[EK70.Z] Cutaneous cysts, unspecified
Also known as: Cutaneous cysts, unspecified | Cutaneous cysts | Follicular cysts of skin and subcutaneous tissue
[FB4Y] Other specified disorders of synovium or tendon
Also known as: Other specified disorders of synovium or tendon | Shortening of tendon | short tendon | Shortening of tibialis anterior | Contracture of tendon
[CA0C] Cyst or mucocele of nose or nasal sinus
Definition: A condition which refers to diseases of the nose and nasal sinus that cause a cyst or mucocele.
A mucocele is any dilatation (typically pathologic) with accumulation of mucus. Mucoceles are benign, epithelium-lined cysts filled with mucus, which can form in the paranasal sinuses. These structures may cause symptoms if sufficiently large or if exerting pressure on surrounding anatomic structures. Symptomatic mucoceles typically require surgical intervention. Mucoceles should be differentiated fro
Also known as: Cyst or mucocele of nose or nasal sinus | cyst of sinus | mucocele of sinus | Cyst of maxillary sinus | cyst of maxillary antrum
[9A7Y] Other specified disorders of the cornea
Also known as: Other specified disorders of the cornea | Secondary disorders of sclera or cornea | Disorders of sclera and cornea in diseases classified elsewhere | Secondary keratitis or keratoconjunctivitis | Keratitis and keratoconjunctivitis in other diseases classified elsewhere
[DA07.6Y] Other specified disturbances in tooth eruption
Also known as: Other specified disturbances in tooth eruption | Neonatal teeth | Natal teeth | Advanced tooth eruption | precocious dentition
Includes: Neonatal teeth | Advanced tooth eruption
[LA30.0] Anodontia
Definition: Anodontia is a genetic disorder commonly defined as the absence of all teeth, affecting both temporary and permanent dentitions, and is extremely rarely encountered in a pure form without any associated abnormalities. Rare but more common than complete anodontia is hypodontia.
Also known as: Anodontia | agomphiasis | agomphosis | anodontism | complete absence of teeth
[QA00.8] Dental examination
Also known as: Dental examination | examination of teeth
[LA30.3] Hyperdontia
Definition: Hyperdontia is the condition of having supernumerary teeth, or teeth which appear in addition to the regular number of teeth.
Also known as: Hyperdontia | Supplementary teeth | Supernumerary teeth | supernumerary tooth | supplemental teeth
Includes: Supplementary teeth | Supernumerary teeth | distomolar
[DA0A.Y] Other specified disorders of teeth and supporting structures
Also known as: Other specified disorders of teeth and supporting structures | Alveolar process haemorrhage | alveolar haemorrhage | Barodontalgia | aerodontalgia
=== GRAPH WALKS ===
--- Walk 1 ---
[FB80.5] Solitary bone cyst
Def: A solitary bone cyst is a benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cas...
--EXCLUDES--> [?] Other cysts of jaw
Def: This is mostly odontogenic cysts but may be also of non-odontogenic source. The mandible and maxilla are the bones with the highest prevalent of cysts in the human body owing to odontogenic and develo...
--CHILD--> [?] Aneurysmal cyst of jaw
--- Walk 2 ---
[FB80.5] Solitary bone cyst
Def: A solitary bone cyst is a benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cas...
--EXCLUDES--> [?] Other cysts of jaw
Def: This is mostly odontogenic cysts but may be also of non-odontogenic source. The mandible and maxilla are the bones with the highest prevalent of cysts in the human body owing to odontogenic and develo...
--CHILD--> [?] Solitary cyst jaw
--- Walk 3 ---
[EK70.Z] Cutaneous cysts, unspecified
--PARENT--> [EK70] Cutaneous cysts
--CHILD--> [EK70.1] Trichilemmal cyst
Def: A trichilemmal (pilar) cyst is a common, typically non-tender, intradermal or subcutaneous cyst. The cysts are typically confined to the scalp and are often multiple. They usually occur sporadically b...
--- Walk 4 ---
[EK70.Z] Cutaneous cysts, unspecified
--PARENT--> [EK70] Cutaneous cysts
--RELATED_TO--> [?] Neonatal milia
--- Walk 5 ---
[FB4Y] Other specified disorders of synovium or tendon
--PARENT--> [?] Disorders of synovium or tendon
Def: This is a group of disorders which affect the synovial joint lining (synovium) and also tendons....
--PARENT--> [?] Soft tissue disorders
--- Walk 6 ---
[FB4Y] Other specified disorders of synovium or tendon
--PARENT--> [?] Disorders of synovium or tendon
Def: This is a group of disorders which affect the synovial joint lining (synovium) and also tendons....
--CHILD--> [FB41] Spontaneous rupture of synovium or tendon
Def: This is a spontaneous rupture to a fluid-filled sac containing viscous fluid which normally acts to decrease friction and also provides a cushion between bones and tendons and/or muscles around a join...
|
[
"[FB80.5] Solitary bone cyst\n Def: A solitary bone cyst is a benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cas...\n --EXCLUDES--> [?] Other cysts of jaw\n Def: This is mostly odontogenic cysts but may be also of non-odontogenic source. The mandible and maxilla are the bones with the highest prevalent of cysts in the human body owing to odontogenic and develo...\n --CHILD--> [?] Aneurysmal cyst of jaw",
"[FB80.5] Solitary bone cyst\n Def: A solitary bone cyst is a benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cas...\n --EXCLUDES--> [?] Other cysts of jaw\n Def: This is mostly odontogenic cysts but may be also of non-odontogenic source. The mandible and maxilla are the bones with the highest prevalent of cysts in the human body owing to odontogenic and develo...\n --CHILD--> [?] Solitary cyst jaw",
"[EK70.Z] Cutaneous cysts, unspecified\n --PARENT--> [EK70] Cutaneous cysts\n --CHILD--> [EK70.1] Trichilemmal cyst\n Def: A trichilemmal (pilar) cyst is a common, typically non-tender, intradermal or subcutaneous cyst. The cysts are typically confined to the scalp and are often multiple. They usually occur sporadically b...",
"[EK70.Z] Cutaneous cysts, unspecified\n --PARENT--> [EK70] Cutaneous cysts\n --RELATED_TO--> [?] Neonatal milia",
"[FB4Y] Other specified disorders of synovium or tendon\n --PARENT--> [?] Disorders of synovium or tendon\n Def: This is a group of disorders which affect the synovial joint lining (synovium) and also tendons....\n --PARENT--> [?] Soft tissue disorders",
"[FB4Y] Other specified disorders of synovium or tendon\n --PARENT--> [?] Disorders of synovium or tendon\n Def: This is a group of disorders which affect the synovial joint lining (synovium) and also tendons....\n --CHILD--> [FB41] Spontaneous rupture of synovium or tendon\n Def: This is a spontaneous rupture to a fluid-filled sac containing viscous fluid which normally acts to decrease friction and also provides a cushion between bones and tendons and/or muscles around a join..."
] |
FB80.5
|
Solitary bone cyst
|
[
{
"from_icd11": "FB80.5",
"icd10_code": "M85412",
"icd10_title": "Solitary bone cyst, left shoulder"
},
{
"from_icd11": "FB80.5",
"icd10_code": "M85441",
"icd10_title": "Solitary bone cyst, right hand"
},
{
"from_icd11": "FB80.5",
"icd10_code": "M8548",
"icd10_title": "Solitary bone cyst, other site"
},
{
"from_icd11": "FB80.5",
"icd10_code": "M8540",
"icd10_title": "Solitary bone cyst, unspecified site"
},
{
"from_icd11": "FB80.5",
"icd10_code": "M854",
"icd10_title": "Solitary bone cyst"
},
{
"from_icd11": "EK70.Z",
"icd10_code": "L729",
"icd10_title": "Follicular cyst of the skin and subcutaneous tissue, unspecified"
},
{
"from_icd11": "EK70.Z",
"icd10_code": "L728",
"icd10_title": "Other follicular cysts of the skin and subcutaneous tissue"
},
{
"from_icd11": "EK70.Z",
"icd10_code": "L60-L75",
"icd10_title": ""
},
{
"from_icd11": "EK70.Z",
"icd10_code": "L72",
"icd10_title": "Follicular cysts of skin and subcutaneous tissue"
},
{
"from_icd11": "CA0C",
"icd10_code": "J341",
"icd10_title": "Cyst and mucocele of nose and nasal sinus"
},
{
"from_icd11": "LA30.0",
"icd10_code": "K000",
"icd10_title": "Anodontia"
},
{
"from_icd11": "QA00.8",
"icd10_code": "Z012",
"icd10_title": "Encounter for dental examination and cleaning"
},
{
"from_icd11": "LA30.3",
"icd10_code": "K001",
"icd10_title": "Supernumerary teeth"
}
] |
M85412
|
Solitary bone cyst, left shoulder
|
A 65-year-old patient diagnosed with severe and chronic TRD and complex PTSD presented with low mood, emotional lability, anhedonia, loss of energy, intrusions and flashbacks, hypervigilance, suicidal thoughts and a wish for euthanasia. The traumatic experiences consisted of maltreatment and emotional neglect in her early childhood and repeated sexual abuse. Recurrent depressive episodes started at the age of 42 years. Current medication consisted of fluoxetine, bupropion, trazodone, lorazepam and oxycodone (for chronic pain). There was a family history of depression, borderline personality disorder and autism spectrum disorder. Previous pharmacotherapy consisted of treatment with selective serotonin and noradrenaline reuptake inhibitors (SSRIs and SNRIs), mirtazapine, bupropion, tricyclic antidepressants (TCAs), lithium, monoamine oxidase inhibitors (MAOIs), pregabaline, quetiapine, doxazosine and benzodiazepines. Trauma therapy including Eye Movement Desensitization and Reprocessing (EMDR) had been unsuccessful because the patient felt flooded with anxiety and it triggered self-harm and suicidality. Esketamine was titrated to a maximum dose of 2.0 mg/kg. Acute side effects consisted of drowsiness, light-headedness, headache, numbness of the body, nausea, and dizziness. Intrusions and dissociation occurred and resulted in anxiety. The patient repeatedly experienced flashbacks of the traumatic events, occurring within 24 h after esketamine administration. The staff offered reassurance and holding. The patient experienced a reduction in the burden caused by the traumatic experiences after experiencing flashbacks. Her mood improved, she was less emotionally unstable and more motivated to undertake activities. The total HDRS and IDS-SR scores decreased from baseline to week 6 from 29 to 25 and 56 to 47 respectively. Trauma therapy was then retried in the form of imaginary exposure (IE), thrice weekly on days that the patient did not receive esketamine. We observed a broader ‘window of tolerance’ during exposure in comparison to the earlier trial of trauma therapy. After several weeks of combined IE and esketamine treatment, flashbacks and intrusions had become less frequent. The esketamine treatment had a total duration of five months and was tapered down before discharge from the ward. We intended to continue outpatient psychotherapy, but this was interrupted due to COVID-19 restrictions. The patient reported that for the first time, she felt safe and resilient enough to talk about her traumatic experiences. The complete narrative can be found in Table 1 . Table 1 Patient characteristics, esketamine treatment, depressive symptoms and patient's narratives. Table 1 Patient characteristics Esketamine treatment HDRS & IDS-SR Patient's perspective Case 1 Female 65 yo TRD, PTSD Titrated to 2 mg/kg, twice weekly for 5 months HDRS 6 → 29 IDS-SR 56 → 47 “The combined treatment with esketamine and IE was arduous because the flashbacks and the exposure were difficult to endure. However, the esketamine treatment enabled me to carry on during psychotherapy. It felt calmer in my mind and less chaotic, and it was ‘easier to let the misery come out’. I had never wanted to talk about the traumatic experiences but now felt safe and resilient enough to do so.” Case 2 Female 66 yo TRD, PTSD Titrated to 2 mg/kg, once or twice weekly for 5 months HDRS 18 → 8 IDS-SR 35 → 45 Missing. Case 3 Female 57 yo TRD, PTSD Titrated to 0.75 mg/kg, twice weekly for 6 weeks HDRS 22 → 26 IDS-SR 58 → 32 “I had put all my hopes on esketamine as the results are very promising. The first session was a strange experience, I couldn't see anymore, couldn't speak properly and I couldn't read well. I was also very nauseous. With the higher dose, I didn't respond well. My whole body cramped, and I couldn't move anymore. Everything hurt from head to toe. I had a very bad feeling in my head, that the trauma was coming back. The last session was like a nightmare from the past, the cramping of my body and the feeling that the trauma had taken over.” Case 4 Female 34 yo TRD, PTSD, personality disorder, OCD and binge-eating Titrated to 1.5 mg/kg, twice weekly, treatment ongoing (>6 weeks) HDRS 30 → 11 IDS-SR 57 → 27 “The esketamine treatment has clearly improved my depression. When I'm depressed, my thoughts are running from left to right, everything is mixed up and I become entangled in it. During the esketamine I feel disconnected from reality. Thoughts, but also (traumatic) events and (unprocessed) emotions come and go. I've noticed that at that time, I can better let go and observe, and put things into perspective much better. After the esketamine dose, I feel significantly better within a few hours. It seems to help me feel better about myself and to feel calmer.” Case 5 Female, 54 yo TRD, PTSD Titrated to 3 mg/kg, twice weekly, treatment ongoing (> a year) HDRS 25 → 15 IDS-SR missing Not requested. HDRS = Hamilton Depression Rating Scale, IDS-SR = Inventory of Depressive Symptomatology – Self Rated, OCD = obsessive compulsive disorder, PTSD = posttraumatic stress disorder, TRD = treatment-resistant depression.
| 4.089844
| 0.967285
|
sec[2]/sec[0]/p[0]
|
en
| 0.999996
|
PMC10200841
|
https://doi.org/10.1016/j.heliyon.2023.e15883
|
[
"esketamine",
"hdrs",
"ptsd",
"traumatic",
"titrated",
"weekly",
"that",
"flashbacks",
"trauma",
"twice"
] |
[
{
"code": "LD27.0Y",
"title": "Other specified ectodermal dysplasia syndromes"
},
{
"code": "6B40",
"title": "Post traumatic stress disorder"
},
{
"code": "6B41",
"title": "Complex post traumatic stress disorder"
},
{
"code": "DA0C.Y",
"title": "Other specified periodontal disease"
},
{
"code": "ND56.8",
"title": "Traumatic amputation of unspecified body region"
},
{
"code": "EF31",
"title": "Traumatic purpura"
},
{
"code": "9A72",
"title": "Traumatic keratitis"
},
{
"code": "8A80.Z",
"title": "Migraine, unspecified"
},
{
"code": "QA76",
"title": "Medication or substance that is known to be an allergen without injury or harm"
},
{
"code": "PL13.6",
"title": "Medication or substance that is known to be an allergen, as mode of injury or harm"
}
] |
=== ICD-11 CODES FOUND ===
[LD27.0Y] Other specified ectodermal dysplasia syndromes
Also known as: Other specified ectodermal dysplasia syndromes | Absence of fingerprints-congenital milia syndrome | Ackerman syndrome | ADULT syndrome | Acro-dermato-ungual-lacrimal-tooth syndrome
[6B40] Post traumatic stress disorder
Definition: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing the traumatic event or events in the present in the form of vivid intrusive memories, flashbacks, or nightmares. Re-experiencing may occur via one or multiple sensory modalities and is typically accompanied by strong or overwhelming emotions, particularly fear or horror, and strong physical sensatio
Also known as: Post traumatic stress disorder | Traumatic neurosis | PTSD - [post traumatic stress disorder] | trauma-related disorders | Battered person syndrome
Includes: Traumatic neurosis
Excludes: Acute stress reaction | Complex post traumatic stress disorder
[6B41] Complex post traumatic stress disorder
Definition: Complex post traumatic stress disorder (Complex PTSD) is a disorder that may develop following exposure to an event or series of events of an extremely threatening or horrific nature, most commonly prolonged or repetitive events from which escape is difficult or impossible (e.g. torture, slavery, genocide campaigns, prolonged domestic violence, repeated childhood sexual or physical abuse). All diagnostic requirements for PTSD are met. In addition, Complex PTSD is characterised by severe and pers
Also known as: Complex post traumatic stress disorder | enduring personality change after catastrophic experience | complex PTSD | personality change after disasters | Personality change after concentration camp experiences
Excludes: Post traumatic stress disorder | Personality disorder
[DA0C.Y] Other specified periodontal disease
Also known as: Other specified periodontal disease | Chronic periodontitis | Adult periodontitis | adult-onset periodontitis | chronic pericementitis
[ND56.8] Traumatic amputation of unspecified body region
Also known as: Traumatic amputation of unspecified body region | avulsion NOS | Traumatic amputation NOS | traumatic avulsion NOS | traumatic extremity loss
Excludes: multiple: crushing injuries NOS | multiple traumatic amputations NOS
[EF31] Traumatic purpura
Definition: Purpura and bruising attributable to trauma which may be self-induced (as from rubbing itchy skin), due to friction from clothing or due to man-handling, particularly of debilitated elderly patients.
Also known as: Traumatic purpura
[9A72] Traumatic keratitis
Also known as: Traumatic keratitis | Photokeratitis | photophthalmia | snow blindness
Excludes: Foreign body in cornea
[8A80.Z] Migraine, unspecified
Also known as: Migraine, unspecified | Migraine
[QA76] Medication or substance that is known to be an allergen without injury or harm
Definition: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm.
Also known as: Medication or substance that is known to be an allergen without injury or harm
Excludes: Medication or substance that is known to be an allergen, as mode of injury or harm
[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm
Also known as: Medication or substance that is known to be an allergen, as mode of injury or harm | medication error relating to known allergy to drug or substance | adverse drug event relating to known allergy to drug or substance
=== GRAPH WALKS ===
--- Walk 1 ---
[LD27.0Y] Other specified ectodermal dysplasia syndromes
--PARENT--> [LD27.0] Ectodermal dysplasia syndromes
Def: Ectodermal dysplasias (EDs) are a heterogeneous group of syndromes characterised by developmental dystrophies of ectodermal structures, such as hypohidrosis, hypotrichosis, onychodysplasia and hypodon...
--RELATED_TO--> [?] Langer-Giedion syndrome
Def: Langer-Giedion syndrome or trichorhinophalangeal syndrome type 2 is a chromosomal anomaly syndrome characterised by the association of intellectual deficit and numerous other anomalies including redun...
--- Walk 2 ---
[LD27.0Y] Other specified ectodermal dysplasia syndromes
--PARENT--> [LD27.0] Ectodermal dysplasia syndromes
Def: Ectodermal dysplasias (EDs) are a heterogeneous group of syndromes characterised by developmental dystrophies of ectodermal structures, such as hypohidrosis, hypotrichosis, onychodysplasia and hypodon...
--RELATED_TO--> [?] Solitary median maxillary central incisor syndrome
Def: Presence of a single maxillary central incisor possibly caused by a mutation in the Sonic hedgehog gene...
--- Walk 3 ---
[6B40] Post traumatic stress disorder
Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...
--PARENT--> [?] Disorders specifically associated with stress
Def: Disorders specifically associated with stress are directly related to exposure to a stressful or traumatic event, or a series of such events or adverse experiences. For each of the disorders in this g...
--EXCLUDES--> [?] Acute stress reaction
Def: Acute stress reaction refers to the development of transient emotional, somatic, cognitive, or behavioural symptoms as a result of exposure to an event or situation (either short- or long-lasting) of ...
--- Walk 4 ---
[6B40] Post traumatic stress disorder
Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...
--PARENT--> [?] Disorders specifically associated with stress
Def: Disorders specifically associated with stress are directly related to exposure to a stressful or traumatic event, or a series of such events or adverse experiences. For each of the disorders in this g...
--EXCLUDES--> [?] Burnout
Def: Burnout is a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed. It is characterised by three dimensions: 1) feelings of energy depletion or exha...
--- Walk 5 ---
[6B41] Complex post traumatic stress disorder
Def: Complex post traumatic stress disorder (Complex PTSD) is a disorder that may develop following exposure to an event or series of events of an extremely threatening or horrific nature, most commonly pr...
--EXCLUDES--> [?] Personality disorder
Def: Personality disorder is characterised by problems in functioning of aspects of the self (e.g., identity, self-worth, accuracy of self-view, self-direction), and/or interpersonal dysfunction (e.g., abi...
--CHILD--> [?] Severe personality disorder
Def: All general diagnostic requirements for Personality Disorder are met. There are severe disturbances in functioning of the self (e.g., sense of self may be so unstable that individuals report not havin...
--- Walk 6 ---
[6B41] Complex post traumatic stress disorder
Def: Complex post traumatic stress disorder (Complex PTSD) is a disorder that may develop following exposure to an event or series of events of an extremely threatening or horrific nature, most commonly pr...
--EXCLUDES--> [?] Post traumatic stress disorder
Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...
--CHILD--> [?] Combat neurosis
|
[
"[LD27.0Y] Other specified ectodermal dysplasia syndromes\n --PARENT--> [LD27.0] Ectodermal dysplasia syndromes\n Def: Ectodermal dysplasias (EDs) are a heterogeneous group of syndromes characterised by developmental dystrophies of ectodermal structures, such as hypohidrosis, hypotrichosis, onychodysplasia and hypodon...\n --RELATED_TO--> [?] Langer-Giedion syndrome\n Def: Langer-Giedion syndrome or trichorhinophalangeal syndrome type 2 is a chromosomal anomaly syndrome characterised by the association of intellectual deficit and numerous other anomalies including redun...",
"[LD27.0Y] Other specified ectodermal dysplasia syndromes\n --PARENT--> [LD27.0] Ectodermal dysplasia syndromes\n Def: Ectodermal dysplasias (EDs) are a heterogeneous group of syndromes characterised by developmental dystrophies of ectodermal structures, such as hypohidrosis, hypotrichosis, onychodysplasia and hypodon...\n --RELATED_TO--> [?] Solitary median maxillary central incisor syndrome\n Def: Presence of a single maxillary central incisor possibly caused by a mutation in the Sonic hedgehog gene...",
"[6B40] Post traumatic stress disorder\n Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...\n --PARENT--> [?] Disorders specifically associated with stress\n Def: Disorders specifically associated with stress are directly related to exposure to a stressful or traumatic event, or a series of such events or adverse experiences. For each of the disorders in this g...\n --EXCLUDES--> [?] Acute stress reaction\n Def: Acute stress reaction refers to the development of transient emotional, somatic, cognitive, or behavioural symptoms as a result of exposure to an event or situation (either short- or long-lasting) of ...",
"[6B40] Post traumatic stress disorder\n Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...\n --PARENT--> [?] Disorders specifically associated with stress\n Def: Disorders specifically associated with stress are directly related to exposure to a stressful or traumatic event, or a series of such events or adverse experiences. For each of the disorders in this g...\n --EXCLUDES--> [?] Burnout\n Def: Burnout is a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed. It is characterised by three dimensions: 1) feelings of energy depletion or exha...",
"[6B41] Complex post traumatic stress disorder\n Def: Complex post traumatic stress disorder (Complex PTSD) is a disorder that may develop following exposure to an event or series of events of an extremely threatening or horrific nature, most commonly pr...\n --EXCLUDES--> [?] Personality disorder\n Def: Personality disorder is characterised by problems in functioning of aspects of the self (e.g., identity, self-worth, accuracy of self-view, self-direction), and/or interpersonal dysfunction (e.g., abi...\n --CHILD--> [?] Severe personality disorder\n Def: All general diagnostic requirements for Personality Disorder are met. There are severe disturbances in functioning of the self (e.g., sense of self may be so unstable that individuals report not havin...",
"[6B41] Complex post traumatic stress disorder\n Def: Complex post traumatic stress disorder (Complex PTSD) is a disorder that may develop following exposure to an event or series of events of an extremely threatening or horrific nature, most commonly pr...\n --EXCLUDES--> [?] Post traumatic stress disorder\n Def: Post traumatic stress disorder (PTSD) may develop following exposure to an extremely threatening or horrific event or series of events. It is characterised by all of the following: 1) re-experiencing ...\n --CHILD--> [?] Combat neurosis"
] |
LD27.0Y
|
Other specified ectodermal dysplasia syndromes
|
[
{
"from_icd11": "6B40",
"icd10_code": "F4310",
"icd10_title": "Post-traumatic stress disorder, unspecified"
},
{
"from_icd11": "6B40",
"icd10_code": "F4312",
"icd10_title": "Post-traumatic stress disorder, chronic"
},
{
"from_icd11": "6B40",
"icd10_code": "F4311",
"icd10_title": "Post-traumatic stress disorder, acute"
},
{
"from_icd11": "6B40",
"icd10_code": "F431",
"icd10_title": "Post-traumatic stress disorder (PTSD)"
},
{
"from_icd11": "6B40",
"icd10_code": "F620",
"icd10_title": ""
},
{
"from_icd11": "6B41",
"icd10_code": "F62",
"icd10_title": ""
},
{
"from_icd11": "ND56.8",
"icd10_code": "T147",
"icd10_title": ""
},
{
"from_icd11": "EF31",
"icd10_code": "D692",
"icd10_title": "Other nonthrombocytopenic purpura"
},
{
"from_icd11": "EF31",
"icd10_code": "D69",
"icd10_title": "Purpura and other hemorrhagic conditions"
},
{
"from_icd11": "9A72",
"icd10_code": "H16122",
"icd10_title": "Filamentary keratitis, left eye"
},
{
"from_icd11": "9A72",
"icd10_code": "H16129",
"icd10_title": "Filamentary keratitis, unspecified eye"
},
{
"from_icd11": "9A72",
"icd10_code": "H16102",
"icd10_title": "Unspecified superficial keratitis, left eye"
},
{
"from_icd11": "9A72",
"icd10_code": "H16142",
"icd10_title": "Punctate keratitis, left eye"
},
{
"from_icd11": "9A72",
"icd10_code": "H16103",
"icd10_title": "Unspecified superficial keratitis, bilateral"
},
{
"from_icd11": "9A72",
"icd10_code": "H16139",
"icd10_title": "Photokeratitis, unspecified eye"
}
] |
F4310
|
Post-traumatic stress disorder, unspecified
|
In August 2022, a 55-year-old Korean man visited an outside hospital because of dyspepsia for 1 month and weight loss of 10 kg in 1 year. Initial abdominal computed tomography revealed mildly decreased and heterogeneous attenuation in the liver with mild periportal edema . A calcified nodule was also observed in the posterior segment of the liver. In October 2022, preliminary laboratory tests performed at another hospital revealed mild anemia (red blood cell count, 3.90 × 10 6 /µL; hemoglobin level, 12.7 g/dL; and hematocrit level, 36.0%) and erythrocyte sedimentation rate of 30 mm. Preliminary liver function test revealed significantly abnormal levels: aspartate aminotransferase, 55.5 U/L; alanine aminotransferase, 24.3 U/L; alkaline phosphatase, 1532 U/L; total bilirubin, 1.67 mg/dL; direct bilirubin, 0.91 mg/dL; gamma-glutamyl transferase, >1500 U/L; and prothrombin time international normalized ratio, 12.3. The patient was treated for an unspecified liver disease; however, his jaundice gradually worsened. Therefore, he visited our outpatient hepatology clinic in December 2022 for further evaluation. He had no significant family or past histological findings. Although he had lost 10 kg in 1 year, other significant symptoms had not appeared until recently. He denied any history of smoking but regularly drank 10 single shots (50 mL) of Soju (popular alcoholic beverage in Korea) (20% alcohol by volume) over 20 years. To improve his symptoms, he had been taking herbal medicine for the past 2 months. Preliminary liver function tests performed 3 months after the onset of symptoms showed more severe abnormal levels: aspartate aminotransferase, 110 U/L; alanine aminotransferase, 57 U/L; alkaline phosphatase, 794 U/L; total bilirubin, 4.21 mg/dL; direct bilirubin, 2.57 mg/dL; gamma-glutamyl transferase, 2846 U/L; and prothrombin time-international normalized ratio, 13. Serological tests for hepatitis B virus, hepatitis C virus, and autoimmune hepatitis were negative. Moreover, no signs of mild anemia were observed (red blood cell count, 3.98 × 10 6 /µL; hemoglobin concentration level, 13.1 g/dL; and hematocrit level, 39.1%). A tumor marker level test revealed significantly elevated levels of carbohydrate antigen 19-9 and β2-microglobulin (3.91 mg/L). Urinalysis revealed dark yellow urine, and bilirubin (3+) was detected. Magnetic resonance cholangiography revealed liver cirrhosis with severe hepatomegaly, but no evidence of splenomegaly or biliary dilatation was noted . Mild ascites in the pelvic cavity were also observed. However, no abnormalities were observed in either of the kidneys. For diagnosis, an ultrasound-guided needle biopsy of the liver was performed using an 18-gauge TSK gun. Hematoxylin and eosin staining of the liver biopsy specimen showed diffuse extracellular, pink-colored amorphous deposits in the perisinusoidal spaces, and most of the hepatocytes were compressed by the deposits . To differentiate it from amyloidosis, Congo red staining was performed, but no apple green birefringence was noted. Immunohistochemically, these deposits were strongly positive for kappa LCs and weakly positive for lambda LCs . Accordingly, the patient was diagnosed with LCDD and further systemic examination was performed. 18 F-fluorodeoxyglucose positron emission tomography revealed no significant abnormal uptake (maximum standardized uptake value of 2.8), with large amounts of ascites and edema in the lower trunk and extremities. However, the serum immunofixation test indicated a distinct M-spike in the β-region, and a monoclonal gammopathy pattern was identified. In contrast, no monoclonal gammopathy pattern was observed on the urine immunofixation test. Bone marrow aspiration and trephine biopsy revealed an increased proportion of neoplastic plasma cells (22.6%) . Therefore, the patient was diagnosed with PCM. In cytogenetic analysis, bone marrow Karyotype with 46, XY was observed, and no numerical or structural abnormalities of chromosomes were found. In addition, no variation in Tier 1 to 3 was observed in the performance of next-generation sequencing using customized multiple myeloma panels consisting of 24 genes via the MiSeqDx instrument (Illumina, CA). In fluorescence in situ hybridization, CKS1B / CDKN2C (P18) amplification/deletion, IGH / MAFB rearrangement, IGH / MAF rearrangement, IGH / FGFR3 rearrangement, IGH / CCND1 rearrangement, TP53 deletion, and atypical anomaly were also not observed. Serum and urine protein electrophoresis tests revealed that the level of free kappa LCs significantly increased , whereas that of free lambda LCs slightly elevated to 35.44 mg/L. These findings are compatible with those of LCDD. Transthoracic echocardiography revealed septal hypertrophy and no abnormalities in left ventricular systolic function. The patient received bortezomib/lenalidomide/dexamethasone (1 cycle) as the treatment regimen for PCM. After 3 days, the patient tested positive for coronavirus disease 2019 and suffered multiple infectious complications, such as general weakness, seizures, and dyspnea, in January 2023, and died 1 month after the liver biopsy.
| 4.042969
| 0.970703
|
sec[1]/p[1]
|
en
| 0.999998
|
PMC10063314
|
https://doi.org/10.1097/MD.0000000000033406
|
[
"liver",
"bilirubin",
"aminotransferase",
"biopsy",
"rearrangement",
"preliminary",
"function",
"significantly",
"however",
"hepatitis"
] |
[
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
},
{
"code": "5C90.1",
"title": "Liver diseases due to disorders of porphyrin or bilirubin metabolism or transport"
},
{
"code": "5C58.00",
"title": "Crigler-Najjar syndrome"
},
{
"code": "5C58.0Z",
"title": "Disorders of bilirubin metabolism or excretion, unspecified"
},
{
"code": "5C58.Z",
"title": "Inborn errors of porphyrin or heme metabolism, unspecified"
},
{
"code": "KA86",
"title": "Neonatal kernicterus"
}
] |
=== ICD-11 CODES FOUND ===
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
[5C90.1] Liver diseases due to disorders of porphyrin or bilirubin metabolism or transport
Definition: These are liver diseases due to disorders of porphyrin and bilirubin metabolism and transport
Also known as: Liver diseases due to disorders of porphyrin or bilirubin metabolism or transport | disease of bilirubin metabolism | disorder of bilirubin metabolism | Liver diseases due to porphyria | Other disorders of bilirubin metabolism or excretion
Excludes: Defects of catalase and peroxidase
[5C58.00] Crigler-Najjar syndrome
Definition: Crigler-Najjar syndrome is an autosomal recessive disorder of bilirubin metabolism characterised by unconjugated hyperbilirubinemia due to a hepatic deficit of bilirubin glucuronosyltransferase activity. Two types have been described, CNS types 1 and 2, depending on whether the enzymatic deficit is complete or partial: clinical manifestations vary accordingly. Patients present with isolated jaundice that appears early in life. Biological analyses detect severe unconjugated hyperbilirubinemia wit
Also known as: Crigler-Najjar syndrome | Bilirubin uridinediphosphate glucuronosyltransferase deficiency | Hereditary unconjugated hyperbilirubinaemia | Bilirubin-UGT deficiency | UGT deficiency
[5C58.0Z] Disorders of bilirubin metabolism or excretion, unspecified
Also known as: Disorders of bilirubin metabolism or excretion, unspecified | Disorders of bilirubin metabolism or excretion
[5C58.Z] Inborn errors of porphyrin or heme metabolism, unspecified
Also known as: Inborn errors of porphyrin or heme metabolism, unspecified | Inborn errors of porphyrin or heme metabolism | defects of catalase and peroxidase | disorders of porphyrin and bilirubin metabolism | Disorders of porphyrin or heme metabolism
[KA86] Neonatal kernicterus
Definition: Kernicterus is a pathologic diagnosis of the neonate that is characterised by yellow staining of the basal ganglia following elevated bilirubin concentrations in the blood and/or a breech in the blood brain barrier more common in the premature infant or the sick term neonate. It is characterised later in infancy and childhood by hearing deficits, choreoathetosis, and varying degrees of cognitive deficit.
Also known as: Neonatal kernicterus | bilirubin encephalopathy | nuclear jaundice | kernicterus of newborn NOS | hyperbilirubinaemia encephalopathy
Excludes: kernicterus due to inborn errors of metabolism
=== GRAPH WALKS ===
--- Walk 1 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--CHILD--> [DB92] Non-alcoholic fatty liver disease
Def: NAFLD is characterised by fatty liver related to insulin resistance in the absence of significant alcohol consumption. It embraces a pathological spectrum from simple steatosis to steatohepatitis. 10-...
--- Walk 2 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--RELATED_TO--> [?] Metabolic or transporter liver disease
--- Walk 3 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Drug-induced or toxic liver disease
Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....
--- Walk 4 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Drug-induced or toxic liver disease
Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....
--- Walk 5 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--CHILD--> [DB99.0] Chronic liver disease
--- Walk 6 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--EXCLUDES--> [?] Hepatic vein thrombosis
Def: Venous thrombosis within the hepatic vein....
|
[
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --CHILD--> [DB92] Non-alcoholic fatty liver disease\n Def: NAFLD is characterised by fatty liver related to insulin resistance in the absence of significant alcohol consumption. It embraces a pathological spectrum from simple steatosis to steatohepatitis. 10-...",
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --RELATED_TO--> [?] Metabolic or transporter liver disease",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Drug-induced or toxic liver disease\n Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Drug-induced or toxic liver disease\n Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --CHILD--> [DB99.0] Chronic liver disease",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --EXCLUDES--> [?] Hepatic vein thrombosis\n Def: Venous thrombosis within the hepatic vein...."
] |
DB9Z
|
Diseases of liver, unspecified
|
[
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K762",
"icd10_title": "Central hemorrhagic necrosis of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K70-K77",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K778",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K72",
"icd10_title": "Hepatic failure, not elsewhere classified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K76",
"icd10_title": "Other diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
}
] |
K7681
|
Hepatopulmonary syndrome
|
A 72-year-old woman was diagnosed twice (at 22 and 33 years of age) with hemolytic anemia and admitted to another hospital. Her medical condition improved after corticosteroid administration, and she was recommended to avoid cold conditions. Subsequently, her medical condition was stable without treatment; however, she experienced sun sensitivity and Raynaud's phenomenon in winters. She was admitted to our hospital due to dyspnea and severe anemia. She experienced progressive shortness of breath and weakness in the lower extremities 1 month before admission. She visited another clinic where laboratory tests revealed severe anemia and jaundice. There was no family history of thromboembolism. She had experienced an anaphylactic shock supposedly due to an antibiotic at 45 years of age and was diagnosed with chronic obstructive pulmonary disease at the age of 68 years. She had no history of thromboembolism and abortion. She had a history of smoking 20 cigarettes per day when she was aged 22–55 years, but she was not a habitual drinker. Her mother had rheumatoid arthritis and SLE. Her husband died of adult T-cell leukemia (ATL). Her daughter is a human T-cell leukemia virus type-1 (HTLV-1) carrier. On admission, her height and body weight were 164 cm and 41 kg, respectively. Her body temperature, blood pressure, pulse rate, and oxygen saturation were 36.8°C, 108/59 mmHg, 78 beats/min, and 92% under room air, respectively. Her eyelid conjunctiva was anemic and ocular conjunctiva was jaundiced. No heart murmur or abnormal chest sounds were heard on auscultation, and no edema was observed in her extremities. The laboratory findings revealed a red blood cell count of 1.3 × 10 6 / μ L, hemoglobin level of 7.2 g/dL, hematocrit level of 18.4%, total bilirubin level of 6.44 mg/dL, indirect bilirubin level of 5.98 mg/dL, lactate dehydrogenase level of 513 U/L, antinuclear antibody titer of 1 : 640 (speckled and cytoplasmic pattern), cold agglutinin titer of 1 : 512, and positivity for cryoglobulin and direct and indirect Coombs tests. Antibodies against hepatitis C virus and HTLV-1 were also detected. The direct antiglobulin test (DAT) revealed positivity for IgG and complement components ( Table 1 ). Peripheral blood smear examination revealed flower cells (3.5% of leukocyte fraction) and red blood cell agglutination . Chest X-ray revealed cardiac enlargement and emphysematous shadows in both the lungs, and computed tomography revealed emphysematous shadows in almost all lung fields, left-side pleural effusion, and splenomegaly . However, brain magnetic resonance imaging revealed no ischemic findings, and no thrombi were detected upon performing venous echocardiography of the lower extremities. Nevertheless, a ventilation/perfusion lung scan revealed several small wedge-shaped defects in the peripheral lung field. An echocardiogram revealed a high right ventricular pressure of 58.3 mmHg, suggesting overload in the right heart. The patient was diagnosed with AIHA based on splenomegaly, low hemoglobin level, increased reticulocyte count, high titer of indirect bilirubin and lactate dehydrogenase, and positive Coombs tests . In addition, according to the European League Against Rheumatism/American College of Rheumatology classification criteria for SLE , she was diagnosed with SLE as she met the criteria of having an antinuclear antibody titer >1 : 80, autoimmune hemolysis (4), pleural effusion (4), lupus anticoagulant (2), and low C3 and C4 levels (4); her total score was 14, which satisfied the requirement for a total score ≥10 for SLE diagnosis. Furthermore, she was diagnosed with APS using the Sydney criteria for APS classification based on the detection of vascular thrombosis (pulmonary thrombosis) and lupus anticoagulant (LAC) in the plasma twice at an interval ≥12 weeks. Furthermore, she was diagnosed as an HTLV-1 carrier because no ATL lesion was observed and only 3.5% of atypical lymphoma was present in the peripheral blood . Subsequently, as both DAT (IgG and complements) and cold agglutinin test were positive, we evaluated the thermal amplitude to exclude the possibility of the presence of clinically insignificant polyclonal cold agglutinins. The thermal amplitude was found to be 30°C (2 times dilution) in this patient. Therefore, she was diagnosed with mixed-type AIHA based on a positive DAT for IgG and C3 and positive cold agglutinin test with a thermal amplitude ≥30°C . She received oxygen on admission. After the diagnosis of SLE and mixed-type AIHA, she was administered prednisolone (40 mg/day) since day 7 of hospitalization. Her dyspnea and hemolytic findings gradually improved after treatment, and oxygen supplementation was discontinued on day 16 of hospitalization. She refused to take warfarin, which was proposed for the treatment of APS. She was discharged on day 26 of hospitalization. The prednisolone dose was tapered during the follow-up period. As she was an HTLV-1 carrier, no immunosuppressants were administered. Although the prednisolone dose was reduced to 10 mg/day, she maintained a good condition with improved right heart overload 6 months later .
| 4.089844
| 0.975098
|
sec[1]/p[0]
|
en
| 0.999998
|
PMC10522428
|
https://doi.org/10.1155/2023/4963196
|
[
"diagnosed",
"cold",
"blood",
"cell",
"htlv",
"titer",
"anemia",
"improved",
"experienced",
"extremities"
] |
[
{
"code": "1F45",
"title": "Malaria without parasitological confirmation"
},
{
"code": "RA01.1",
"title": "COVID-19, virus not identified"
},
{
"code": "CA00",
"title": "Acute nasopharyngitis"
},
{
"code": "CA22.Z",
"title": "Chronic obstructive pulmonary disease, unspecified"
},
{
"code": "NF03.Z",
"title": "Unspecified effects of reduced temperature"
},
{
"code": "1F00.01",
"title": "Herpes simplex labialis"
},
{
"code": "3A20.1",
"title": "Autoimmune haemolytic anaemia, cold type"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
}
] |
=== ICD-11 CODES FOUND ===
[1F45] Malaria without parasitological confirmation
Definition: Clinically diagnosed malaria without parasitological confirmation
Also known as: Malaria without parasitological confirmation | marsh fever | remittent congestive fever | coastal fever | remittent gastric fever
Includes: clinically diagnosed malaria without parasitological confirmation
[RA01.1] COVID-19, virus not identified
Also known as: COVID-19, virus not identified | clinically diagnosed COVID-19 | suspected COVID-19 | probable COVID-19 | clinical COVID-19
Excludes: COVID-19, virus identified | Coronavirus infection, unspecified site | Special screening examination for other viral diseases
[CA00] Acute nasopharyngitis
Definition: A disease of the upper respiratory tract, caused by an infection with rhinovirus. This disease is characterised by pharyngitis, runny nose, stuffy nose, or cough. Transmission is by inhalation of infected respiratory secretions, or direct contact.
Also known as: Acute nasopharyngitis | acute infective rhinitis | cold | common cold | coryza
Excludes: Chronic nasopharyngitis | pharyngitis NOS | Acute pharyngitis
[CA22.Z] Chronic obstructive pulmonary disease, unspecified
Also known as: Chronic obstructive pulmonary disease, unspecified | Chronic obstructive pulmonary disease | COPD - [chronic obstructive pulmonary disease] | COAD - [chronic obstructive airways disease] | COLD - [chronic obstructive lung disease]
[NF03.Z] Unspecified effects of reduced temperature
Also known as: Unspecified effects of reduced temperature | Other effects of reduced temperature | adverse effect of cold | cold effects | exposure to cold
[1F00.01] Herpes simplex labialis
Also known as: Herpes simplex labialis | cold sore | herpes simplex infection of lip | fever blister | herpetic fever
Includes: cold sore
[3A20.1] Autoimmune haemolytic anaemia, cold type
Definition: Cold autoimmune haemolytic anaemia comprises two types of autoimmune haemolytic anaemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold haemoglobinuria (PCH). CAD is more common in people over the age of 55 years, while PCH typically presents in young children. CAD is caused by IgM autoantibodies while PCH is caused by an IgG immunoglobulin.
Also known as: Autoimmune haemolytic anaemia, cold type | autoimmune haemolytic anaemia due to cold antibodies | idiopathic cold autoimmune haemolytic anaemia | autoimmune cold sense | autoimmune cold sensitivity
Includes: Cold haemagglutinin disease
Excludes: Immune thrombocytopenic purpura | Haemolytic disease of fetus or newborn
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
=== GRAPH WALKS ===
--- Walk 1 ---
[1F45] Malaria without parasitological confirmation
Def: Clinically diagnosed malaria without parasitological confirmation...
--PARENT--> [?] Malaria
Def: A disease caused by an infection with a protozoan parasite from the Plasmodium genus. This disease commonly presents with fever, chills, headache, nausea and vomiting, or malaise. Transmission is thro...
--RELATED_TO--> [?] HIV disease clinical stage 3 associated with malaria
--- Walk 2 ---
[1F45] Malaria without parasitological confirmation
Def: Clinically diagnosed malaria without parasitological confirmation...
--PARENT--> [?] Malaria
Def: A disease caused by an infection with a protozoan parasite from the Plasmodium genus. This disease commonly presents with fever, chills, headache, nausea and vomiting, or malaise. Transmission is thro...
--CHILD--> [1F41] Malaria due to Plasmodium vivax
Def: A disease caused by an infection with the protozoan parasite Plasmodium vivax. This disease is characterised by fever, chills, headache, nausea and vomiting, body aches, or general malaise. Transmissi...
--- Walk 3 ---
[RA01.1] COVID-19, virus not identified
--EXCLUDES--> [?] COVID-19, virus identified
--EXCLUDES--> [?] Middle East respiratory syndrome
Def: A disease caused by an infection with Middle East Respiratory Syndrome coronavirus (MERS-CoA). This disease is characterised by severe acute respiratory illness with fever, cough, and shortness of bre...
--- Walk 4 ---
[RA01.1] COVID-19, virus not identified
--EXCLUDES--> [?] Coronavirus infection, unspecified site
--EXCLUDES--> [?] Severe acute respiratory syndrome
Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...
--- Walk 5 ---
[CA00] Acute nasopharyngitis
Def: A disease of the upper respiratory tract, caused by an infection with rhinovirus. This disease is characterised by pharyngitis, runny nose, stuffy nose, or cough. Transmission is by inhalation of infe...
--EXCLUDES--> [?] Acute pharyngitis
Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o...
--EXCLUDES--> [?] Chronic pharyngitis
Def: Persistent or recurrent inflammation of the pharynx; the funnel-shaped fibromuscular tube which conducts food to the oesophagus and air to the larynx....
--- Walk 6 ---
[CA00] Acute nasopharyngitis
Def: A disease of the upper respiratory tract, caused by an infection with rhinovirus. This disease is characterised by pharyngitis, runny nose, stuffy nose, or cough. Transmission is by inhalation of infe...
--EXCLUDES--> [?] Acute pharyngitis
Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o...
--EXCLUDES--> [?] Chronic pharyngitis
Def: Persistent or recurrent inflammation of the pharynx; the funnel-shaped fibromuscular tube which conducts food to the oesophagus and air to the larynx....
|
[
"[1F45] Malaria without parasitological confirmation\n Def: Clinically diagnosed malaria without parasitological confirmation...\n --PARENT--> [?] Malaria\n Def: A disease caused by an infection with a protozoan parasite from the Plasmodium genus. This disease commonly presents with fever, chills, headache, nausea and vomiting, or malaise. Transmission is thro...\n --RELATED_TO--> [?] HIV disease clinical stage 3 associated with malaria",
"[1F45] Malaria without parasitological confirmation\n Def: Clinically diagnosed malaria without parasitological confirmation...\n --PARENT--> [?] Malaria\n Def: A disease caused by an infection with a protozoan parasite from the Plasmodium genus. This disease commonly presents with fever, chills, headache, nausea and vomiting, or malaise. Transmission is thro...\n --CHILD--> [1F41] Malaria due to Plasmodium vivax\n Def: A disease caused by an infection with the protozoan parasite Plasmodium vivax. This disease is characterised by fever, chills, headache, nausea and vomiting, body aches, or general malaise. Transmissi...",
"[RA01.1] COVID-19, virus not identified\n --EXCLUDES--> [?] COVID-19, virus identified\n --EXCLUDES--> [?] Middle East respiratory syndrome\n Def: A disease caused by an infection with Middle East Respiratory Syndrome coronavirus (MERS-CoA). This disease is characterised by severe acute respiratory illness with fever, cough, and shortness of bre...",
"[RA01.1] COVID-19, virus not identified\n --EXCLUDES--> [?] Coronavirus infection, unspecified site\n --EXCLUDES--> [?] Severe acute respiratory syndrome\n Def: A disease of the respiratory system, caused by an infection with coronavirus. This disease is characterised by fever, headache, cough, myalgia, tachycardia, or diarrhoea. This disease may also lead to...",
"[CA00] Acute nasopharyngitis\n Def: A disease of the upper respiratory tract, caused by an infection with rhinovirus. This disease is characterised by pharyngitis, runny nose, stuffy nose, or cough. Transmission is by inhalation of infe...\n --EXCLUDES--> [?] Acute pharyngitis\n Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o...\n --EXCLUDES--> [?] Chronic pharyngitis\n Def: Persistent or recurrent inflammation of the pharynx; the funnel-shaped fibromuscular tube which conducts food to the oesophagus and air to the larynx....",
"[CA00] Acute nasopharyngitis\n Def: A disease of the upper respiratory tract, caused by an infection with rhinovirus. This disease is characterised by pharyngitis, runny nose, stuffy nose, or cough. Transmission is by inhalation of infe...\n --EXCLUDES--> [?] Acute pharyngitis\n Def: Acute pharyngitis is defined as an infection or irritation of the pharynx and/or tonsils and is a part of the common cold symptoms. The etiology is usually infectious, with most cases being of viral o...\n --EXCLUDES--> [?] Chronic pharyngitis\n Def: Persistent or recurrent inflammation of the pharynx; the funnel-shaped fibromuscular tube which conducts food to the oesophagus and air to the larynx...."
] |
1F45
|
Malaria without parasitological confirmation
|
[
{
"from_icd11": "1F45",
"icd10_code": "B54",
"icd10_title": "Unspecified malaria"
},
{
"from_icd11": "CA00",
"icd10_code": "J00",
"icd10_title": "Acute nasopharyngitis [common cold]"
},
{
"from_icd11": "CA22.Z",
"icd10_code": "J449",
"icd10_title": "Chronic obstructive pulmonary disease, unspecified"
},
{
"from_icd11": "CA22.Z",
"icd10_code": "J440",
"icd10_title": "Chronic obstructive pulmonary disease with (acute) lower respiratory infection"
},
{
"from_icd11": "CA22.Z",
"icd10_code": "J44",
"icd10_title": "Other chronic obstructive pulmonary disease"
},
{
"from_icd11": "CA22.Z",
"icd10_code": "J448",
"icd10_title": ""
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T699XXA",
"icd10_title": "Effect of reduced temperature, unspecified, initial encounter"
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T699XXS",
"icd10_title": "Effect of reduced temperature, unspecified, sequela"
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T698XXA",
"icd10_title": "Other specified effects of reduced temperature, initial encounter"
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T69",
"icd10_title": "Other effects of reduced temperature"
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T698",
"icd10_title": "Other specified effects of reduced temperature"
},
{
"from_icd11": "NF03.Z",
"icd10_code": "T699",
"icd10_title": "Effect of reduced temperature, unspecified"
},
{
"from_icd11": "1F00.01",
"icd10_code": "B0089",
"icd10_title": "Other herpesviral infection"
},
{
"from_icd11": "1F00.01",
"icd10_code": "B0082",
"icd10_title": "Herpes simplex myelitis"
},
{
"from_icd11": "1F00.01",
"icd10_code": "B0081",
"icd10_title": "Herpesviral hepatitis"
}
] |
B54
|
Unspecified malaria
|
We characterized, both clinically and genetically, a consanguineous Pakistani family suffering from pyruvate kinase deficiency (PKD). The family belonged to a Pashtun ethnic group living in the Peshawar municipality, and consisted of three patients; the proband (III.6), her brother (III.4), and one first cousin (III.1), all born to consanguineous parents . However, genetic testing was performed on the proband only. The proband is currently a 13-year-old female who was born full term to a consanguineous couple. At clinical examination, the proband experienced chronic, most likely congenital nonautoimmune hemolytic anemia at birth, and thus was recommended for transfusion. Transfusion was started regularly since she was 22 days old, with a frequency of once a month to once every 3 months. Along with transfusion, an oral supplementation of folic acid 1 mg, daily was recommended for 30 days to stabilize the patient’s hemoglobin level. The proband had an axillary temperature of 36.1 °C, peripheral pulse rate of 114 beats per minute, respiratory rate of 24 breaths per minute, systolic blood pressure of 94 mm Hg, diastolic blood pressure of 500 mm Hg, oxygen saturation of 99%, height of 94.3 cm, weight of 13.4 kg, body mass index of 15.1 kg/m 2 , and body surface area of 0.59 m 2 . The proband’s height and weight remained at the third percentile though her both parents were relatively tall, likely indicating a lack of expected normal physiological development in childhood. The proband’s blood group type was AB-negative. Immunization was up to date, and no known allergies were revealed upon clinical investigation. Echocardiogram (echo) was unremarkable. Examination of the musculoskeletal, neurologic, lymphatic, and integumentary systems revealed no adverse outcomes. Abdominal examination revealed hepatomegaly (palpable, 2.6 cm below the right costal margin, smooth, not tender), splenomegaly (palpable, 2 cm below left costal margin, smooth edged, not tender; spleen size 8.8 cm). Bone marrow aspirate showed a markedly decreased myeloid to erythroid (M/E) ratio, and marked hypercellular marrow particles due to hyperplasia of the erythroid elements with normal maturation. However, myeloid maturation was normal and the number of megakaryocytes were also within the normal range, thus excluding evidence of red cell aplasia, myelodysplastic syndrome, or congenital dyserythropoietic anemia (CDA). Screening for paroxysmal nocturnal hemoglobinuria (PNH) was also negative. Measurements of blood hemoglobin (Hb) and pyruvate kinase (PK) levels were extremely low at 7.6 g/dL and 12.4 U/g Hb, respectively (Table 1 ). Based on the clinical findings, a final diagnosis of pyruvate kinase deficiency (PKD) was confirmed in the proband. Fig. 1 Pedigree of a Pakistani family segregating PKLR mutation. Filled symbols indicate patients while blank symbols represent healthy individuals. Symbols carrying a central dot shows obligate carriers. M = Mutation; + = Wild-type allele. Proband in the pedigree is indicated by a small arrow Table 1 Clinical and genetic data of a Pakistani family with pyruvate kinase deficiency. Demographic and clinical information Genetic findings Age 13 years Basic variant information Sex Female Chromosome location 1q22 Residence Peshawar Genomic position 155264127 Ethnicity/language Pashtun/Pashto Gene symbol PKLR ABO, Rh blood type AB, negative Gene name Pyruvate kinase L/R Hemoglobin (Hb) 7.6 gm/dL Ensembl Gene ID ENSG00000143627 Pyruvate kinase (PK) 12.4 U/g Hb OMIM ID 609712 Spleen Palpable, splenomegaly (spleen size 8.8 cm) Transcript ID NM_000298.6 Liver Palpable, hepatomegaly Protein ID NP_000289.1 Temperature (Axillary) 36.1 °C Exon number 7 Peripheral pulse rate 114 cDNA change c.1015G > A Respiratory rate 24 br/minute Protein change p.Asp339Asn Systolic blood pressure 94 mm Hg Variant type SNV Diastolic blood pressure 50 mm Hg Variant status Novel Oxygen saturation 0.99 RS ID rs747097960 Height (third percentile) 94.3 cm In silico analysis Weight (third percentile) 13.4 kg gnomAD (All) MAF 0.00001592 Body surface area (BSA) 0.59 m 2 gnomAD (South Asian) MAF 0.0001307 Body mass index (BMI) 15.1 kg/m 2 gnomAD homozygotes 0 Folic acid 1 mg, PO, daily, 30 days ACMG classification Likely pathogenic Transfusion started 22 days after birth ClinVar/HGMD N/A Transfusion frequency Once a month to once every 3 months DEOGEN2 Damaging Allergies No known allergies LRT Deleterious Bone marrow biopsy Marked erythroid hyperplasia with marked reticulocytosis MutPred Pathogenic Musculoskeletal Normal strength Mutation assessor Highly damaging Lymphatics No lymphadenopathy MutationTaster Disease causing Integumentary No rash PROVEAN Damaging Neurologic Alert PrimateAI Damaging Sodium level 137 mmol/L REVEL Pathogenic Potassium level 4.1 mmol/L SIFT Damaging Chloride Level 109 mmol/L Polyphen-2 Probably damaging CO 2 22 mmol/L FATHMM-MKL Damaging AGAP 6 mmol/L DANN 0.9993 Miscellaneous Lack of expected normal physiological development in childhood CADD PHRED score (GRCh37-v1.6) 29.5 Final diagnosis Pyruvate kinase deficiency Evolutionary conservation score (PhyloP100way) 7.564
| 4.234375
| 0.584473
|
sec[2]/sec[0]/p[0]
|
en
| 0.999996
|
35168679
|
https://doi.org/10.1186/s13256-022-03292-z
|
[
"proband",
"pyruvate",
"kinase",
"blood",
"damaging",
"transfusion",
"mmol",
"family",
"deficiency",
"pressure"
] |
[
{
"code": "5C53.0Z",
"title": "Disorders of pyruvate metabolism, unspecified"
},
{
"code": "5C53.0Y",
"title": "Other specified disorders of pyruvate metabolism"
},
{
"code": "5C53.02",
"title": "Pyruvate dehydrogenase complex deficiency"
},
{
"code": "5C53.00",
"title": "Pyruvate kinase deficiency"
},
{
"code": "5C53.03",
"title": "Pyruvate carboxylase deficiency"
},
{
"code": "5C51.1",
"title": "Disorders of glycerol metabolism"
},
{
"code": "5C52.10",
"title": "Disorders of cholesterol synthesis"
},
{
"code": "5C54.2",
"title": "Disorders of multiple glycosylation or other pathways"
},
{
"code": "5C51.3",
"title": "Glycogen storage disease"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[5C53.0Z] Disorders of pyruvate metabolism, unspecified
Also known as: Disorders of pyruvate metabolism, unspecified | Disorders of pyruvate metabolism | disorders of pyruvate metabolism and gluconeogenesis | Gluconeogenesis disorder
[5C53.0Y] Other specified disorders of pyruvate metabolism
Also known as: Other specified disorders of pyruvate metabolism | Phosphoenolpyruvate carboxykinase deficiency | PEPCK - [Phosphoenolpyruvate carboxykinase] deficiency | Phosphoenolpyruvate carboxykinase 1 deficiency | PEPCK 1 - [Phosphoenolpyruvate carboxykinase 1] deficiency
[5C53.02] Pyruvate dehydrogenase complex deficiency
Definition: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestations range from often fatal, severe, neonatal to later-onset neurological disorders.
Also known as: Pyruvate dehydrogenase complex deficiency | Ataxia with lactic acidosis | PDC - [Pyruvate dehydrogenase complex] deficiency | pyruvate dehydrogenase deficiency | ataxia with lactic acidosis 1
[5C53.00] Pyruvate kinase deficiency
Definition: This refers to an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP.
Also known as: Pyruvate kinase deficiency
[5C53.03] Pyruvate carboxylase deficiency
Definition: This is a deficiency in the enzyme of the ligase class that catalyzes the (depending on the species) irreversible carboxylation of pyruvate to form oxaloacetate (OAA).
Also known as: Pyruvate carboxylase deficiency | Ataxia with lactic acidosis type II
[5C51.1] Disorders of glycerol metabolism
Also known as: Disorders of glycerol metabolism | Glycerol kinase deficiency | Hyperglycerolaemia | Isolated glycerol kinase deficiency | Glycerol kinase deficiency - contiguous gene syndrome
[5C52.10] Disorders of cholesterol synthesis
Also known as: Disorders of cholesterol synthesis | Mevalonate kinase deficiency | Mevalonic aciduria | Smith-Lemli-Opitz syndrome | 7-dehydrocholesterol reductase deficiency
[5C54.2] Disorders of multiple glycosylation or other pathways
Also known as: Disorders of multiple glycosylation or other pathways | Dolichol-phosphate-mannose synthase 1 deficiency | GDP-Man: Dol-P-mannosyltransferase deficiency | Carbohydrate deficient glycoprotein syndrome type 1E | Congenital disorder of glycosylation type 1E
[5C51.3] Glycogen storage disease
Definition: The term Glycogen storage disease characterises a group of heterogeneous diseases resulting from defects in the process of glycogen synthesis or breakdown within muscles, liver, and other cell types.
Also known as: Glycogen storage disease | Glycogenosis | GSD - [Glycogen storage disease] | glycogen thesaurismosis | diffuse glycogenosis
Includes: Glycogen storage disease due to LAMP-2 deficiency | Glycogen storage disease due to glycogen debranching enzyme deficiency | Glycogen storage disease due to muscle glycogen phosphorylase deficiency
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[5C53.0Z] Disorders of pyruvate metabolism, unspecified
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--PARENT--> [5C53] Inborn errors of energy metabolism
--- Walk 2 ---
[5C53.0Z] Disorders of pyruvate metabolism, unspecified
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency
Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...
--- Walk 3 ---
[5C53.0Y] Other specified disorders of pyruvate metabolism
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--CHILD--> [5C53.00] Pyruvate kinase deficiency
Def: This refers to an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP....
--- Walk 4 ---
[5C53.0Y] Other specified disorders of pyruvate metabolism
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency
Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...
--- Walk 5 ---
[5C53.02] Pyruvate dehydrogenase complex deficiency
Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency
Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...
--- Walk 6 ---
[5C53.02] Pyruvate dehydrogenase complex deficiency
Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...
--PARENT--> [5C53.0] Disorders of pyruvate metabolism
--CHILD--> [5C53.01] Lactate dehydrogenase deficiency
Def: This refers to a deficiency in the enzyme present in a wide variety of organisms, including plants and animals. This exists in four distinct enzyme classes. Two of them are cytochrome c-dependent enzy...
|
[
"[5C53.0Z] Disorders of pyruvate metabolism, unspecified\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --PARENT--> [5C53] Inborn errors of energy metabolism",
"[5C53.0Z] Disorders of pyruvate metabolism, unspecified\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency\n Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...",
"[5C53.0Y] Other specified disorders of pyruvate metabolism\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --CHILD--> [5C53.00] Pyruvate kinase deficiency\n Def: This refers to an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP....",
"[5C53.0Y] Other specified disorders of pyruvate metabolism\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency\n Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...",
"[5C53.02] Pyruvate dehydrogenase complex deficiency\n Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --CHILD--> [5C53.02] Pyruvate dehydrogenase complex deficiency\n Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...",
"[5C53.02] Pyruvate dehydrogenase complex deficiency\n Def: Pyruvate dehydrogenase deficiency (PDHD) is a rare neurometabolic disorder characterised by a wide range of clinical signs with metabolic and neurological components of varying severity. Manifestation...\n --PARENT--> [5C53.0] Disorders of pyruvate metabolism\n --CHILD--> [5C53.01] Lactate dehydrogenase deficiency\n Def: This refers to a deficiency in the enzyme present in a wide variety of organisms, including plants and animals. This exists in four distinct enzyme classes. Two of them are cytochrome c-dependent enzy..."
] |
5C53.0Z
|
Disorders of pyruvate metabolism, unspecified
|
[
{
"from_icd11": "5C53.0Z",
"icd10_code": "E744",
"icd10_title": "Disorders of pyruvate metabolism and gluconeogenesis"
},
{
"from_icd11": "5C54.2",
"icd10_code": "E778",
"icd10_title": "Other disorders of glycoprotein metabolism"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7401",
"icd10_title": "von Gierke disease"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7404",
"icd10_title": "McArdle disease"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7402",
"icd10_title": "Pompe disease"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7403",
"icd10_title": "Cori disease"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7409",
"icd10_title": "Other glycogen storage disease"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E7400",
"icd10_title": "Glycogen storage disease, unspecified"
},
{
"from_icd11": "5C51.3",
"icd10_code": "E740",
"icd10_title": "Glycogen storage disease"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
}
] |
E744
|
Disorders of pyruvate metabolism and gluconeogenesis
|
The woman was asymptomatic, and two day-3 embryos were transferred. The luteal phase was supported with vaginal progesterone at a dose of 200 mg, twice a day (Prometrium®, Rottapharm). Twelve days after embryo transfer, the patient began to develop nausea and vomiting, abdominal pain, dyspnea and oliguria. Physical examination revealed paleness, dehydration, abdominal tension and lung hypoventilation. The patient was apyretic and had normal blood pressure, pulse rate and oxygen saturation values. The patient’s weight was 86.5 kg at the first control. Transvaginal sonography demonstrated an ovarian enlargement (left ovary 84 × 63 mm, right ovary 79 × 61 mm) and massive ascites. Blood analysis indicated hemoconcentration (hematocrit 46,1%, white blood cells 19.010/ml, platelets 855.000/ml), hyperkalemia (5,1 mmol/l) and hypoproteinemia (total protein concentration 59 g/l and albumin 27 g/l). There was no evidence of renal and hepatic failure. Serum b-hCG was 182 U/L. The patient was admitted to the Hospital with a diagnosis of critical OHSS and underwent continuous monitoring and a supportive therapy consisting of oral and intravenous hydration, colloid fluids, crystalloid fluids, human albumin infusion and prophylactic doses of low molecular weight heparin. Daily records of fluid intake and urine output were performed. Despite a conservative approach, the clinical condition did not improve, the intensity of dyspnea and abdominal tension increased, and the patient’s weight reached 87,5 kg. After 4 days of treatment the patient complained of dyspnea, tachycardia and sweating, and was therefore treated also with oxygen, furosemide (10 mg/day) and cabergoline (0,5 mg/day) and underwent abdominal paracentesis. The patient was transferred to the Intensive Care Unit (ICU) of the Hospital because of the onset of mild hydropericardium and moderate pleural effusion. The cabergolin therapy was not tolerated by the patient, due to severe asthenia, and was therefore interrupted. During the recovery in ICU, the patient was treated with parental nutrition, continuous dopamine infusion (3 γ /kg/min), intravenous hydration and plasma expanders; paracentesis was repeated, and an albumin therapy was started for ascites and mild pleural and pericardiac effusion. When the respiratory and abdominal symptoms worsened, beta-hCG level was 1057 U/L. At that time, the ultrasound scan showed a single gestational sac with a fetus at the 5 th week of gestation. Laboratory tests revealed a reduction in hemoconcentration (hematocrit 41,5%, white blood cells 13.000/ml, platelets 385.000/ml), but an increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), which were 0,67 ukat/l and 1,17 ukat/l, respectively. Over the next 15 days, a gradual reduction of ovarian size and ascites, as well as of the pleural and pericardial effusions, were achieved and the patient was transferred to the Obstetric Unit. A new transvaginal ultrasound exam revealed two gestational sacs, one containing a fetus at 6 weeks of gestational age, while the other one was a blighted ovum; in addition, ultrasound scan revealed a reduced ascites and ovarian volume. A few days later, the patient complained of a generalized itch and jaundice. Laboratory tests highlighted hematocrit 31,2%, platelets 636.000/ml, increased liver enzymes (AST 3,2 ukat/l, ALT 9,55 ukat/l), total bilirubin 7,9 umol/L, increased bile acids 48 umol/L. Viral hepatology tests (hepatitis A, B and C) were negative. Hepatic ultrasound scan showed a slightly inhomogeneous liver structure, dense bile and non-dilated bile ducts. Gastroenterologic advice diagnosed advanced ICP following OHSS. The patient started a treatment with ursodeoxycholic acid 300, mg twice a day, which brought to an improvement of her clinical conditions. A new ultrasound scan showed two gestational sacs, one containing a fetus at 8 weeks of gestational age and the other without embryo. Free fluid was absent and ovaries presented a regular volume. Laboratory analysis showed that AST, ALT and bile acid levels were 0,42 ukat/l, 2,23 ukat/l, and 4,1 umol/L respectively, and reached normal levels in one week, so the patient was discharged. Blood tests performed during pregnancy and after delivery showed a normal liver function. The pregnancy continued without other complications until the 36 th week of gestation, when the patient developed ICP in the third trimester, becoming symptomatic (itch). The patient underwent cesarean section because of increased levels of bile acids (86 umol/L) and acute fetal distress during cardiotocographic (CTG) monitoring; the newborn was a healthy baby of 2500 g with an Apgar score of 9–10. Both the post-partum and the puerperium periods had a regular course. Based on a multidisciplinary discussion with gynecologists, anesthesiologists, gastroenterologists and a molecular biologist expert in genetics predisposition, a genetic study was performed on the patient analyzing the possible presence of multi-drug-resistance protein 3 ( MDR3 ) gene variants in exons 14, 15 and 16, but the sequence analysis of the polymorphisms resulted negative.
| 3.888672
| 0.977539
|
sec[1]/p[1]
|
en
| 0.999998
|
37330509
|
https://doi.org/10.1186/s12905-023-02471-4
|
[
"ukat",
"abdominal",
"blood",
"ultrasound",
"gestational",
"bile",
"ascites",
"scan",
"umol",
"transferred"
] |
[
{
"code": "MD81.3",
"title": "Acute abdomen"
},
{
"code": "JA01.0",
"title": "Abdominal pregnancy"
},
{
"code": "ME04.Z",
"title": "Ascites, unspecified"
},
{
"code": "NB51.0&XA3KX0",
"title": "Laceration without foreign body of abdominal wall"
},
{
"code": "NB9Y",
"title": "Other specified injuries to the abdomen, lower back, lumbar spine or pelvis"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
}
] |
=== ICD-11 CODES FOUND ===
[MD81.3] Acute abdomen
Definition: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases
Also known as: Acute abdomen | acute abdominal pain syndrome | surgical abdomen | abdominal acute syndrome | severe abdomen pain
[JA01.0] Abdominal pregnancy
Definition: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy.
Also known as: Abdominal pregnancy | abdomen pregnancy | intraperitoneal pregnancy
Excludes: Maternal care for viable fetus in abdominal pregnancy | Delivery of viable fetus in abdominal pregnancy
[ME04.Z] Ascites, unspecified
Also known as: Ascites, unspecified | Ascites | abdominal dropsy | hydrops abdominis | ascites NOS
[NB9Y] Other specified injuries to the abdomen, lower back, lumbar spine or pelvis
Also known as: Other specified injuries to the abdomen, lower back, lumbar spine or pelvis | Abdominal wall trauma | Injury of pelvic floor | pelvic floor blunt injury | pelvic floor blunt trauma
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
=== GRAPH WALKS ===
--- Walk 1 ---
[MD81.3] Acute abdomen
Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...
--PARENT--> [MD81] Abdominal or pelvic pain
Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....
--EXCLUDES--> [?] Flatulence and related conditions
Def: Production or presence of gas in the gastrointestinal tract which may be expelled through the anus and other conditions associated with the production or presence of gas in the GI tract....
--- Walk 2 ---
[MD81.3] Acute abdomen
Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...
--PARENT--> [MD81] Abdominal or pelvic pain
Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....
--EXCLUDES--> [?] Renal colic
Def: A severe paroxysmal pain in the flank radiating to the groin, scrotum or labia, caused by blockage of the renal pelvis or ureter most commonly by a renal stone. May be associated with nausea and vomit...
--- Walk 3 ---
[JA01.0] Abdominal pregnancy
Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....
--EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy
Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...
--PARENT--> [?] Other assisted single delivery
--- Walk 4 ---
[JA01.0] Abdominal pregnancy
Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....
--EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy
Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...
--PARENT--> [?] Other assisted single delivery
--- Walk 5 ---
[ME04.Z] Ascites, unspecified
--PARENT--> [ME04] Ascites
Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...
--CHILD--> [ME04.Y] Other specified ascites
--- Walk 6 ---
[ME04.Z] Ascites, unspecified
--PARENT--> [ME04] Ascites
Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...
--CHILD--> [ME04.Y] Other specified ascites
|
[
"[MD81.3] Acute abdomen\n Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...\n --PARENT--> [MD81] Abdominal or pelvic pain\n Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....\n --EXCLUDES--> [?] Flatulence and related conditions\n Def: Production or presence of gas in the gastrointestinal tract which may be expelled through the anus and other conditions associated with the production or presence of gas in the GI tract....",
"[MD81.3] Acute abdomen\n Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...\n --PARENT--> [MD81] Abdominal or pelvic pain\n Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....\n --EXCLUDES--> [?] Renal colic\n Def: A severe paroxysmal pain in the flank radiating to the groin, scrotum or labia, caused by blockage of the renal pelvis or ureter most commonly by a renal stone. May be associated with nausea and vomit...",
"[JA01.0] Abdominal pregnancy\n Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....\n --EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy\n Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...\n --PARENT--> [?] Other assisted single delivery",
"[JA01.0] Abdominal pregnancy\n Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....\n --EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy\n Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...\n --PARENT--> [?] Other assisted single delivery",
"[ME04.Z] Ascites, unspecified\n --PARENT--> [ME04] Ascites\n Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...\n --CHILD--> [ME04.Y] Other specified ascites",
"[ME04.Z] Ascites, unspecified\n --PARENT--> [ME04] Ascites\n Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...\n --CHILD--> [ME04.Y] Other specified ascites"
] |
MD81.3
|
Acute abdomen
|
[
{
"from_icd11": "MD81.3",
"icd10_code": "R100",
"icd10_title": "Acute abdomen"
},
{
"from_icd11": "JA01.0",
"icd10_code": "O0000",
"icd10_title": "Abdominal pregnancy without intrauterine pregnancy"
},
{
"from_icd11": "JA01.0",
"icd10_code": "O000",
"icd10_title": "Abdominal pregnancy"
},
{
"from_icd11": "ME04.Z",
"icd10_code": "R180",
"icd10_title": "Malignant ascites"
},
{
"from_icd11": "ME04.Z",
"icd10_code": "R18",
"icd10_title": "Ascites"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
}
] |
R100
|
Acute abdomen
|
A 90-year-old man was referred to our institution in May 2017 for diagnosis and treatment of an oral lesion. He had first noticed the lesion approximately 1 year earlier. The lesion grew gradually and showed rapid enlargement in the last 6 months. The patient's medical history included atrial fibrillation treated with warfarin, hyperlipidemia, resected rectal cancer, and internal carotid artery stenosis treated by carotid endarterectomy. All of these conditions were followed up and controlled by the patient's physicians. He had smoked cigarettes from age 23 to 48 years, resulting in a Brinkman index of 3,000. His family history was unremarkable. Intraoral examination revealed that a hard mass measuring 35 × 27 mm was located on the floor of the oral cavity and attached to the bone. The overlying oral mucosa was partially ulcerated. The growth of the mass displaced the tongue posteriorly, resulting in a Mallampati score of IV ; therefore, he experienced difficulty with speech and swallowing. There was no evidence of cranial nerve paralysis or cervical lymphadenopathy. Cone-beam computed tomography (CT) (3D Accuitomo F17; Morita, Kyoto, Japan) revealed that the mass was connected to the cortical bone of the mandible. The mass was inhomogeneous and spread to the left mandibular body . Magnetic resonance imaging was performed with a 3.0-Tesla system (MR750; General Electric Company, Boston, MA, USA). On T1- and T2-weighted axial images, the mass showed low signal intensity relative to muscle. Positron emission tomography (PET)/CT was performed with a Discovery PET/CT 600 scanner (General Electric Company). The image showed abnormal accumulation of fluorodeoxyglucose in the mandibular lesion (maximum standardized uptake value: 7.2) . There was no abnormal accumulation of fluorodeoxyglucose in any other organ. Biopsy of the mandibular mass was suspicious for chondrosarcoma. The American Society of Anesthesiologists (ASA) physical status was class 3. Echocardiography revealed an ejection fraction of 64% without ischemic or valvular heart disease. Spirography revealed that forced expiratory volume in 1 second was 64.8%, suggesting slight obstructive ventilation disorder. Magnetic resonance angiography of the internal carotid artery revealed no evidence of restenosis after carotid endarterectomy. Preoperative examination did not detect critical risks for general anesthesia and surgery, although their duration was reduced as much as possible. No method other than surgical treatment could have resolved his chief complaint. Heparin bridging was scheduled for atrial fibrillation treated with warfarin before surgery. Based on a clinical diagnosis of a malignant bone tumor of the mandible (cT1N0M0), segmental mandibular resection with reconstruction using a titanium plate was performed in June. Although the Mallampati score was IV, tracheal intubation was not difficult without trismus. During the operation, a surgical safety margin of about 10 mm was set in the normal-looking tissue. First, we reached the inferior border of the mandible through cervical incision. Next, we made an intraoral incision on the buccal gingiva. By resecting soft tissue around the tumor, we connected the oral wound to the cervical one. This procedure exposed the lateral surface of the tumor with surrounding soft tissue. The medial border was cut by the surgical saw, and the mandible was swung to the left side to visualize the inner surface of the tumor. By directly viewing the tumor attached to the bone, the oral floor was incised . Resection of the tumor with surrounding normal soft tissue was performed backward, and the inferior alveolar nerve and vascular bundles were ligated and cut. Finally, mandibular segmental resection was completed by cutting the mandibular ramus at the distal border. After removal of the tumor, the mandible was reconstructed using a titanium plate that was prepared preoperatively based on a 3D mandibular model. Operation time was 5 h, and the amount of bleeding was 389 g. After the operation, the patient received frequent nursing care. The resected mandibular specimen revealed dominant exophilic proliferation ( Figure 5(a) ), and the cut surface of the tumor after fixing with formalin showed infiltration to the alveolar bone ( Figure 5(b) ). Histopathological examination revealed that trabeculae with low calcification spread radially in the periphery of the tumor. Tumor cells with mild atypia were present densely with partial cartilage ossification . The surgically resected margins were negative for tumor. The final histopathological diagnosis was low-grade osteosarcoma (stage IA). Surgical site infection occurred on postoperative day 12, which was resolved by drainage, local irrigation, and administration of antibiotics. There was no delirium or cardiovascular or pulmonary complications. Surgery resolved the patient's speech and swallowing difficulties. He continued to come to our hospital alone on foot for regular clinical check-up. There was no evidence of tumor recurrence or metastasis 4 years after surgery by evaluation with panoramic radiography and chest X-ray.
| 3.972656
| 0.97998
|
sec[1]/p[0]
|
en
| 0.999998
|
PMC8947915
|
https://doi.org/10.1155/2022/2622551
|
[
"tumor",
"mandibular",
"oral",
"that",
"bone",
"mandible",
"lesion",
"carotid",
"tissue",
"treated"
] |
[
{
"code": "2F9Z",
"title": "Neoplasms of unknown behaviour of unspecified site"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "2E6Z",
"title": "Carcinoma in situ of unspecified site"
},
{
"code": "2F91.1",
"title": "Neoplasms of unknown behaviour of trachea, bronchus or lung"
},
{
"code": "2F92",
"title": "Neoplasms of unknown behaviour of skin"
},
{
"code": "DA0E.8",
"title": "Temporomandibular joint disorders"
},
{
"code": "DA0E.0Y&XA51B7",
"title": "Mandibular hypoplasia"
},
{
"code": "QB51.6",
"title": "Presence of tooth-root or mandibular implants"
},
{
"code": "LD2F.16",
"title": "Otomandibular dysplasia"
},
{
"code": "NA02.7Z",
"title": "Fracture of mandible, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[2F9Z] Neoplasms of unknown behaviour of unspecified site
Also known as: Neoplasms of unknown behaviour of unspecified site | neoplasia | neoplasm growth NOS | tumour of unspecified site | tumourlet of unspecified site
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[2E6Z] Carcinoma in situ of unspecified site
Also known as: Carcinoma in situ of unspecified site | carcinoma in situ of unspecified site | carcinoma in situ NOS | carcinoma in situ | in situ neoplasm
[2F91.1] Neoplasms of unknown behaviour of trachea, bronchus or lung
Also known as: Neoplasms of unknown behaviour of trachea, bronchus or lung | trachea, bronchus or lung tumour NOS | Intravascular bronchial alveolar tumour of unspecified site | Bronchial adenoma of unknown behaviour of unspecified site | Intravascular bronchial alveolar tumour unknown behaviour of unspecified site
[2F92] Neoplasms of unknown behaviour of skin
Also known as: Neoplasms of unknown behaviour of skin | skin tumour NOS
[DA0E.8] Temporomandibular joint disorders
Definition: This is an umbrella term covering acute or chronic pain, especially in the muscles of mastication and/or inflammation of the temporomandibular joint, which connects the mandible to the skull.
Also known as: Temporomandibular joint disorders | temporomandibular joint disease | temporomandibular jaw disorder | TMJ - [temporomandibular joint] disorder | temporomandibular developmental disorder of jaw
Includes: Temporomandibular joint-pain-dysfunction syndrome | Derangement of temporomandibular joint | Chronic temporomandibular disorder pain
Excludes: current temporomandibular joint: strain | current temporomandibular joint: dislocation
[QB51.6] Presence of tooth-root or mandibular implants
Also known as: Presence of tooth-root or mandibular implants | presence of tooth root implant | presence of mandibular implant
[LD2F.16] Otomandibular dysplasia
Definition: Any condition characterised by malformation of facial bones and muscles. These conditions may present with eyes that slant downward, sparse eyelashes, eyelid coloboma, hearing loss, underdeveloped or absent vertebrae, or cleft palate.
Also known as: Otomandibular dysplasia | Oculo-auriculo-vertebral spectrum with radial defects | Auriculo-condylar syndrome | Goldenhar syndrome | Hemifacial microsomia
[NA02.7Z] Fracture of mandible, unspecified
Also known as: Fracture of mandible, unspecified | Fracture of mandible | fracture of lower jaw | mandibular fracture | jaw fracture
=== GRAPH WALKS ===
--- Walk 1 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--PARENT--> [02] Neoplasms
Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....
--- Walk 2 ---
[2F9Z] Neoplasms of unknown behaviour of unspecified site
--PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs
--- Walk 3 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Localised adiposity
Def: A condition characterised by accumulation of adipose tissue in specific regions of the body....
--CHILD--> [?] Fatty apron
--- Walk 4 ---
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...
--EXCLUDES--> [?] Breast lump or mass female
--PARENT--> [?] Symptoms, signs or clinical findings involving the female genital system
--- Walk 5 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system
--- Walk 6 ---
[2E6Z] Carcinoma in situ of unspecified site
--PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
--CHILD--> [2E60] Carcinoma in situ of oral cavity, oesophagus or stomach
|
[
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --PARENT--> [02] Neoplasms\n Def: An abnormal or uncontrolled cellular proliferation which is not coordinated with an organism's requirements for normal tissue growth, replacement or repair....",
"[2F9Z] Neoplasms of unknown behaviour of unspecified site\n --PARENT--> [?] Neoplasms of unknown behaviour, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2F91] Neoplasms of unknown behaviour of middle ear, respiratory or intrathoracic organs",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Localised adiposity\n Def: A condition characterised by accumulation of adipose tissue in specific regions of the body....\n --CHILD--> [?] Fatty apron",
"[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature\n Def: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature...\n --EXCLUDES--> [?] Breast lump or mass female\n --PARENT--> [?] Symptoms, signs or clinical findings involving the female genital system",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E62] Carcinoma in situ of middle ear or respiratory system",
"[2E6Z] Carcinoma in situ of unspecified site\n --PARENT--> [?] In situ neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues\n --CHILD--> [2E60] Carcinoma in situ of oral cavity, oesophagus or stomach"
] |
2F9Z
|
Neoplasms of unknown behaviour of unspecified site
|
[
{
"from_icd11": "2F9Z",
"icd10_code": "D487",
"icd10_title": "Neoplasm of uncertain behavior of other specified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D482",
"icd10_title": "Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D37-D48",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D377",
"icd10_title": ""
},
{
"from_icd11": "2F9Z",
"icd10_code": "D48",
"icd10_title": "Neoplasm of uncertain behavior of other and unspecified sites"
},
{
"from_icd11": "2F9Z",
"icd10_code": "D489",
"icd10_title": "Neoplasm of uncertain behavior, unspecified"
},
{
"from_icd11": "ME61",
"icd10_code": "R2240",
"icd10_title": "Localized swelling, mass and lump, unspecified lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2232",
"icd10_title": "Localized swelling, mass and lump, left upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2242",
"icd10_title": "Localized swelling, mass and lump, left lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2231",
"icd10_title": "Localized swelling, mass and lump, right upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2241",
"icd10_title": "Localized swelling, mass and lump, right lower limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R2233",
"icd10_title": "Localized swelling, mass and lump, upper limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2243",
"icd10_title": "Localized swelling, mass and lump, lower limb, bilateral"
},
{
"from_icd11": "ME61",
"icd10_code": "R2230",
"icd10_title": "Localized swelling, mass and lump, unspecified upper limb"
},
{
"from_icd11": "ME61",
"icd10_code": "R220",
"icd10_title": "Localized swelling, mass and lump, head"
}
] |
D487
|
Neoplasm of uncertain behavior of other specified sites
|
A healthy five-year-old African American girl was admitted on the sixth day of fever (> 39 °C) and severe headache after 3 days of amoxicillin treatment for group A streptococcal pharyngitis. Initial laboratory data included a white blood cell count of 10.8 bil/L (lymphocytes 1.8 bil/L), Westergren sedimentation rate 30 mm/h, sodium 133 mmol/L, normal liver enzyme concentrations, and clear chest radiograph. Nasopharyngeal swab was positive for SARS-CoV-2 RNA using the NxTAG® CoV Extended Panel (Luminex). Her parents were recently ill with respiratory tract infections and SARS-CoV-2 IgG was positive after their recovery. Daily fever and headache persisted. A head CT scan on day 9 of illness was normal. She was discharged on day 10 but then readmitted later that evening following an episode of confusion and associated extremity stiffening with the appearance of staring into space, which lasted for 2 min. On readmission, CSF studies showed clear fluid with a white blood cell count of 24/μL (96% lymphocytes), red blood cell count 152/μL, protein 85 mg/dL (normal range, 15–45), and glucose 22 mg/dL (normal range, 50–80). Meningitis/encephalitis nucleic acid amplification panel using FilmArray® ME (Biofire) was negative for herpes simplex virus, human herpes virus VI (HHV-6), varicella-zoster virus, enterovirus, cytomegalovirus, parechovirus, Cryptococcus neoformans/gatti , Escherichia coli K1, Haemophilus influenzae type b, Listeria monocytogenes , Neisseria meningitidis , Streptococcus agalactiae , and Streptococcus pneumoniae . SARS-CoV-2 RNA was not detected in CSF using the Centers for Disease Control and Prevention 2019-nCoV Real-Time Reverse Transcriptase-PCR Diagnostic Panel (CDC qPCR). CSF bacterial culture was sterile. Her peripheral blood white blood cell count was 11.1 bil/L (lymphocytes 1.1 bil/L), platelet count 366 bil/L, sodium 130 mmol/L, ferritin 137 ng/mL, lactate dehydrogenase (LDH) 411 U/L, d-dimer 972 ng/mL, fibrinogen 316 mg/dL, troponin I < 0.01 ng/mL, and interleukin 6 level < 5 pg/mL. Oral hydroxychloroquine (6.5 mg/kg/dose every 12 h for two doses and then 3.5 mg/kg/dose per dose every 12 h for four more days) plus oral azithromycin 10 mg/kg/day for 5 days were started. Magnetic resonance imaging (MRI) of the brain with gadolinium on day 12 of illness revealed a 7 mm area of restriction diffusion involving the subcortical white matter of the medial aspect of the left anterior frontal lobe with increased T2 FLAIR signal without pathological enhancement . Mild leptomeningeal enhancement was noted . She developed SIADH (syndrome of inappropriate secretion of antidiuretic hormone) that was managed with fluid restriction and frequent 3% saline boluses. Her fever persisted but she was neurologically stable with waxing and waning cognition and headache, until day 15 when she became more lethargic and developed asymmetric pupils. Head CT scan showed enlargement of the lateral, third, and fourth ventricles. On day 16, repeat lumbar puncture showed an opening pressure of 35 cm of water. CSF studies revealed a hazy fluid with a white blood cell count of 160/μL (44% neutrophils, 51% lymphocytes, 5% monocytes), red blood cell count 7/μL, glucose 30 mg/dL, and protein 112 mg/dL; HHV-6 DNA was detected but not SARS-CoV-2 RNA. An external ventricular drain was placed the same day and the CSF was negative for both HHV-6 DNA and SARS-CoV-2 RNA. She had no HHV-6 DNA in plasma and her HHV-6 IgM was < 1:20 and HHV-6 IgG 1:320 (negative if < 1:10), suggesting that the detection of HHV-6 DNA on lumbar CSF was a false-positive result. MRI of the brain showed extensive progression of the meningoencephalitis to her cerebellum and corpus callosum, with leptomeningeal enhancement especially over the surface of the brainstem and into the auditory canals; magnetic resonance angiography (MRA) was normal . Intravenous dexamethasone was initiated. On day 17, she was intubated for worsening encephalopathy and intravenous remdesivir was started. Her chest radiograph showed early perihilar streaky opacities. Ferritin, interleukin 6, and LDH concentrations were again normal. Fig. 1 Selected sequential MRI/MRA images. a Diffusion-weighted image shows a 7 mm area of restriction diffusion in the left anterior frontal lobe subcortical white matter (arrow), day 12 of illness; b T1-weighted image with gadolinium showing mild leptomeningeal enhancement along the tentorium, day 12; c Diffusion-weighted image showing no restriction diffusion in the left anterior frontal lobe subcortical white matter, day 16; d T2 FLAIR shows abnormal increased signal mainly involving the midbrain, bilateral deep frontal, and bilateral medial temporal areas, day 16; e 3-D time of flight MRA shows a normal circle of Willis, day 16; f T1-weighted image with gadolinium showing diffuse leptomeningeal enhancement, day 16; g T2 FLAIR showing extensive grey matter lesions involving the deep frontal lobe, temporal lobe, midbrain, and cerebellar vermis, with no obvious cerebellar involvement, day 30; h 3-D time of flight MRA showing no flow in intracranial vessels with flow in extracranial vessels, day 30
| 4.09375
| 0.969727
|
sec[1]/p[0]
|
en
| 0.999996
|
32907595
|
https://doi.org/10.1186/s12887-020-02308-1
|
[
"white",
"blood",
"count",
"cell",
"sars",
"diffusion",
"frontal",
"lobe",
"enhancement",
"lymphocytes"
] |
[
{
"code": "EF5Y",
"title": "Other specified dermatoses attributable to hyperviscosity or microvascular occlusion"
},
{
"code": "JB41.1",
"title": "Deep phlebothrombosis in the puerperium"
},
{
"code": "EB60.Y",
"title": "Lichen sclerosus of other specified sites"
},
{
"code": "MC80.00",
"title": "White coat hypertension"
},
{
"code": "1F2D.2",
"title": "White piedra"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
}
] |
=== ICD-11 CODES FOUND ===
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
Also known as: Other specified dermatoses attributable to hyperviscosity or microvascular occlusion | Cutaneous microvascular occlusion by platelet plugs | Cutaneous microvascular disturbances due to myeloproliferative disorder-associated platelet plugs | Cutaneous microvascular disturbances due to paroxysmal nocturnal haemoglobinuria-associated platelet plugs | Cutaneous microvascular occlusion by emboli
[JB41.1] Deep phlebothrombosis in the puerperium
Also known as: Deep phlebothrombosis in the puerperium | postnatal deep vein thrombosis | postpartum deep phlebothrombosis | postpartum deep-vein thrombosis | DVT - [deep venous thrombosis] postnatal
[EB60.Y] Lichen sclerosus of other specified sites
Also known as: Lichen sclerosus of other specified sites | Extragenital lichen sclerosus | Guttate lichen sclerosus | White spot disease | Guttate scleroderma
[MC80.00] White coat hypertension
Definition: Persistently elevated office blood pressure readings with persistently normal out-of-the-office readings.
Also known as: White coat hypertension | white coat syndrome
[1F2D.2] White piedra
Definition: A disease of the hair shaft, caused by an infection with the fungi Trichosporon beigelii. This disease is characterised by irregular, soft, white, or light brown nodules which adhere to the hair follicle. Transmission is by direct contact with contaminated soil or water, or by airborne transmission. Confirmation is by identification of Trichosporon beigelii in a hair follicle sample.
Also known as: White piedra | Trichosporosis nodosa
Includes: Trichosporosis nodosa
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
=== GRAPH WALKS ===
--- Walk 1 ---
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
--PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion
Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....
--RELATED_TO--> [?] Disseminated intravascular coagulation
Def: A disorder that is characterised by the systemic intravascular activation of the coagulation system, simultaneously leading to intravascular thrombi, compromising an adequate blood supply to the organ...
--- Walk 2 ---
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
--PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion
Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....
--PARENT--> [?] Disorders of cutaneous blood and lymphatic vessels
--- Walk 3 ---
[JB41.1] Deep phlebothrombosis in the puerperium
--PARENT--> [JB41] Venous complications in the puerperium
--CHILD--> [JB41.2] Haemorrhoids in the puerperium
--- Walk 4 ---
[JB41.1] Deep phlebothrombosis in the puerperium
--PARENT--> [JB41] Venous complications in the puerperium
--EXCLUDES--> [?] Venous complications in pregnancy
--- Walk 5 ---
[EB60.Y] Lichen sclerosus of other specified sites
--PARENT--> [EB60] Lichen sclerosus
Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...
--CHILD--> [EB60.Y] Lichen sclerosus of other specified sites
--- Walk 6 ---
[EB60.Y] Lichen sclerosus of other specified sites
--PARENT--> [EB60] Lichen sclerosus
Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...
--CHILD--> [EB60.Y] Lichen sclerosus of other specified sites
|
[
"[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion\n --PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion\n Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....\n --RELATED_TO--> [?] Disseminated intravascular coagulation\n Def: A disorder that is characterised by the systemic intravascular activation of the coagulation system, simultaneously leading to intravascular thrombi, compromising an adequate blood supply to the organ...",
"[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion\n --PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion\n Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....\n --PARENT--> [?] Disorders of cutaneous blood and lymphatic vessels",
"[JB41.1] Deep phlebothrombosis in the puerperium\n --PARENT--> [JB41] Venous complications in the puerperium\n --CHILD--> [JB41.2] Haemorrhoids in the puerperium",
"[JB41.1] Deep phlebothrombosis in the puerperium\n --PARENT--> [JB41] Venous complications in the puerperium\n --EXCLUDES--> [?] Venous complications in pregnancy",
"[EB60.Y] Lichen sclerosus of other specified sites\n --PARENT--> [EB60] Lichen sclerosus\n Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...\n --CHILD--> [EB60.Y] Lichen sclerosus of other specified sites",
"[EB60.Y] Lichen sclerosus of other specified sites\n --PARENT--> [EB60] Lichen sclerosus\n Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...\n --CHILD--> [EB60.Y] Lichen sclerosus of other specified sites"
] |
EF5Y
|
Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
|
[
{
"from_icd11": "JB41.1",
"icd10_code": "O871",
"icd10_title": "Deep phlebothrombosis in the puerperium"
},
{
"from_icd11": "1F2D.2",
"icd10_code": "B362",
"icd10_title": "White piedra"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
}
] |
O871
|
Deep phlebothrombosis in the puerperium
|
A 51-year-old man was admitted to our hospital for further examination and treatment, including surgery for a pancreatic tumor, detected using abdominal ultrasound (US) and computed tomography (CT). He had no history of malignancy, and physical and laboratory examinations, including tumor markers, revealed no specific findings. Contrast-enhanced CT and gadolinium-ethoxybenzyl-diethylenetriamine pantaacetic acid (Gd-EOB-DPTA)–enhanced magnetic resonance imaging (MRI) revealed a nodule that was gradually contrasted in the pancreatic head . No enlarged lymph nodes or distant metastases were evident. Endoscopic retrograde cholangiopancreatography showed no pancreatic duct dilation or irregularity. Pancreatic juice cytology showed no malignancy. Endoscopic US revealed a well-defined hypoechoic 19 × 13 mm mass on the ventral side of the pancreatic head. Accordingly, pancreatic cancer was suspected and PD with D2 lymph node dissection was performed. A macroscopic examination of the resected specimen showed a well-circumscribed 21 × 15 mm nodule in the pancreatic head . A postoperative pathological examination revealed a well-differentiated invasive ductal adenocarcinoma with lymphatic invasion and lymph node metastasis (N1; 1/19) . The tumor was classified as stage IIB (pT2N1M0) according to the 8th edition of the International Union Against Cancer Tumor Node Metastasis classification. The patient experienced postoperative pancreatic fistula (Clavien–Dindo grade IIIa) , which was treated with drainage and antibiotic agents, and was discharged on postoperative day 50. Two months after the surgery, adjuvant chemotherapy containing gemcitabine was administered at a dose of 1700 mg on days 1, 8, and 15 every 4 weeks for 1 year. Thereafter, the carbohydrate antigen 19-9 (CA19-9) level was within the normal range and a follow-up CT revealed no local recurrence or distant metastasis. However, at 8 years after the first surgery, the serum CA19-9 level was elevated (130.3 U/mL). Additionally, CT identified a 10-mm low-density area in liver segment 5 , while Gd-EOB-DPTA–enhanced MRI revealed a well-defined mass in the area . Positron emission tomography/CT also revealed high fluorine-18-fluorodeoxyglucose uptake only in this hepatic tumor . Furthermore, upper and lower gastrointestinal endoscopy revealed no malignant findings. No other distant metastases were observed. Accordingly, he was diagnosed with liver metastasis of PDAC. Because the liver metastasis was isolated long after the initial surgery, we decided to resect it using laparoscopic partial hepatectomy of segment 5 at 8 years and 1 month after the PD. A macroscopic examination of the resected specimen revealed a 10 × 9 mm nodular tumor under the liver subcapsular region . A postoperative pathological examination demonstrated well to moderately differentiated adenocarcinoma with no continuity between the liver tumor and the peripheral bile duct. Additionally, immunostaining was positive for cytokeratin 17 (CK17) and MUC5AC, and the immunostaining findings of the metastatic lesion were consistent with those of the primary lesion . Based on the above results, the final pathological diagnosis was liver metastasis of PDAC. We planned to administer chemotherapy for 6 months. However, the patient strongly hoped to continue adjuvant chemotherapy beyond that period. For this reason, he received adjuvant chemotherapy for 1 year. No evidence of recurrence was noted at 11 years after the PD and 3 years after the hepatic resection. Fig. 1 Contrast-enhanced CT and Gd-EOB-DPTA–enhanced MRI revealed a nodule that was gradually contrasted in the pancreatic head (arrow). a Arterial phase of CT. b Portal phase of CT. c Early phase of MRI. d Late phase of MRI. CT, computed tomography; Gd-EOB-DPTA, gadolinium-ethoxybenzyl-diethylenetriamine; MRI, magnetic resonance imaging Fig. 2 Macroscopic examination of the resected specimen identified a well-circumscribed 21 × 15mm nodule in the pancreatic head (arrow) Fig. 3 Histopathological findings (hematoxylin–eosin staining) showing well-differentiated invasive ductal adenocarcinoma with lymphatic invasion. a × 4 and b × 40 original magnification Fig. 4 a Contrast-enhanced CT showing a 10-mm low-density area in liver segment 5 (arrow). b Gd-EOB-DPTA–enhanced MRI showing a well-defined mass in liver segment 5 (arrow). c PET/CT showing the liver mass with high fluorine-18-fluorodeoxyglucose uptake (arrow). CT, computed tomography; Gd-EOB-DPTA, gadolinium-ethoxybenzyl-diethylenetriamine; MRI, magnetic resonance imaging; PET, positron emission tomography Fig. 5 Macroscopic examination of the revealed specimen showed a nodular 10 × 9 mm tumor under the liver subcapsular region Fig. 6 Histopathological findings (hematoxylin–eosin staining) showing a well to moderately differentiated adenocarcinoma compatible with a metastasis of pancreatic ductal adenocarcinoma. a × 4 and b × 40 original magnification Fig. 7 Histopathological findings (immunostaining × 4 original magnification) showing positive cytokeratin 17 and MUC5AC results in the primary lesion ( a , b ) and metastatic lesion ( c , d )
| 4.003906
| 0.974121
|
sec[1]/p[0]
|
en
| 0.999996
|
32621095
|
https://doi.org/10.1186/s40792-020-00924-8
|
[
"pancreatic",
"liver",
"well",
"tumor",
"enhanced",
"metastasis",
"dpta",
"tomography",
"head",
"adenocarcinoma"
] |
[
{
"code": "DC3Z",
"title": "Diseases of pancreas, unspecified"
},
{
"code": "DC3Y",
"title": "Other specified diseases of pancreas"
},
{
"code": "LB21.3",
"title": "Agenesis-aplasia of pancreas"
},
{
"code": "LB21.Z",
"title": "Structural developmental anomalies of pancreas, unspecified"
},
{
"code": "DC35.0",
"title": "Atrophy of pancreas"
},
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[DC3Z] Diseases of pancreas, unspecified
Also known as: Diseases of pancreas, unspecified
[DC3Y] Other specified diseases of pancreas
Also known as: Other specified diseases of pancreas | Calculus of pancreas | pancreas calculi | pancreas duct calculus | pancreas duct lithiasis
[LB21.3] Agenesis-aplasia of pancreas
Definition: This refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue of the pancreas.
Also known as: Agenesis-aplasia of pancreas | Congenital absence of pancreas | Congenital pancreas absence | Congenital pancreatic absence | Absent pancreas
[LB21.Z] Structural developmental anomalies of pancreas, unspecified
Also known as: Structural developmental anomalies of pancreas, unspecified | Structural developmental anomalies of pancreas | malformations of pancreas | anomalies of pancreas | congenital abnormality of pancreas
[DC35.0] Atrophy of pancreas
Also known as: Atrophy of pancreas | pancreatic atrophy | pancreas ductal atrophy
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
=== GRAPH WALKS ===
--- Walk 1 ---
[DC3Z] Diseases of pancreas, unspecified
--PARENT--> [?] Diseases of pancreas
Def: This is a group of conditions characterised as being in or associated with the pancreas....
--CHILD--> [DC32] Chronic pancreatitis
--- Walk 2 ---
[DC3Z] Diseases of pancreas, unspecified
--PARENT--> [?] Diseases of pancreas
Def: This is a group of conditions characterised as being in or associated with the pancreas....
--RELATED_TO--> [?] Structural developmental anomalies of pancreas
--- Walk 3 ---
[DC3Y] Other specified diseases of pancreas
--PARENT--> [?] Diseases of pancreas
Def: This is a group of conditions characterised as being in or associated with the pancreas....
--CHILD--> [DC30] Cystic diseases of the pancreas
Def: This is a closed sac, having a distinct membrane and division compared to the nearby tissue, which may contain air, fluids, or semi-solid material, of the pancreas....
--- Walk 4 ---
[DC3Y] Other specified diseases of pancreas
--PARENT--> [?] Diseases of pancreas
Def: This is a group of conditions characterised as being in or associated with the pancreas....
--CHILD--> [DC31] Acute pancreatitis
Def: Inflammation of the pancreas with sudden onset. Pathological changes range from oedema to necrosis. While mild cases often recover without complications, severe cases have high mortality due to system...
--- Walk 5 ---
[LB21.3] Agenesis-aplasia of pancreas
Def: This refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue of the pancreas....
--PARENT--> [LB21] Structural developmental anomalies of pancreas
--CHILD--> [LB21.2] Accessory pancreas
Def: Accessory pancreas is an asymptomatic embryopathy characterised by the presence of pancreatic tissue in other sites of the body such as the splenic pedicle, gonadic pedicles, intestinal mesentery, duo...
--- Walk 6 ---
[LB21.3] Agenesis-aplasia of pancreas
Def: This refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue of the pancreas....
--PARENT--> [LB21] Structural developmental anomalies of pancreas
--CHILD--> [LB21.0] Annular pancreas
Def: Annular pancreas is a distinct form of duodenal atresia in which the head of the pancreas forms a ring around the second portion of the duodenum. During the neonatal period, the clinical picture is do...
|
[
"[DC3Z] Diseases of pancreas, unspecified\n --PARENT--> [?] Diseases of pancreas\n Def: This is a group of conditions characterised as being in or associated with the pancreas....\n --CHILD--> [DC32] Chronic pancreatitis",
"[DC3Z] Diseases of pancreas, unspecified\n --PARENT--> [?] Diseases of pancreas\n Def: This is a group of conditions characterised as being in or associated with the pancreas....\n --RELATED_TO--> [?] Structural developmental anomalies of pancreas",
"[DC3Y] Other specified diseases of pancreas\n --PARENT--> [?] Diseases of pancreas\n Def: This is a group of conditions characterised as being in or associated with the pancreas....\n --CHILD--> [DC30] Cystic diseases of the pancreas\n Def: This is a closed sac, having a distinct membrane and division compared to the nearby tissue, which may contain air, fluids, or semi-solid material, of the pancreas....",
"[DC3Y] Other specified diseases of pancreas\n --PARENT--> [?] Diseases of pancreas\n Def: This is a group of conditions characterised as being in or associated with the pancreas....\n --CHILD--> [DC31] Acute pancreatitis\n Def: Inflammation of the pancreas with sudden onset. Pathological changes range from oedema to necrosis. While mild cases often recover without complications, severe cases have high mortality due to system...",
"[LB21.3] Agenesis-aplasia of pancreas\n Def: This refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue of the pancreas....\n --PARENT--> [LB21] Structural developmental anomalies of pancreas\n --CHILD--> [LB21.2] Accessory pancreas\n Def: Accessory pancreas is an asymptomatic embryopathy characterised by the presence of pancreatic tissue in other sites of the body such as the splenic pedicle, gonadic pedicles, intestinal mesentery, duo...",
"[LB21.3] Agenesis-aplasia of pancreas\n Def: This refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue of the pancreas....\n --PARENT--> [LB21] Structural developmental anomalies of pancreas\n --CHILD--> [LB21.0] Annular pancreas\n Def: Annular pancreas is a distinct form of duodenal atresia in which the head of the pancreas forms a ring around the second portion of the duodenum. During the neonatal period, the clinical picture is do..."
] |
DC3Z
|
Diseases of pancreas, unspecified
|
[
{
"from_icd11": "DC3Z",
"icd10_code": "K8681",
"icd10_title": "Exocrine pancreatic insufficiency"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K8689",
"icd10_title": "Other specified diseases of pancreas"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K869",
"icd10_title": "Disease of pancreas, unspecified"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K868",
"icd10_title": "Other specified diseases of pancreas"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K87",
"icd10_title": "Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K80-K87",
"icd10_title": ""
},
{
"from_icd11": "DC3Z",
"icd10_code": "K86",
"icd10_title": "Other diseases of pancreas"
},
{
"from_icd11": "DC3Z",
"icd10_code": "K871",
"icd10_title": ""
},
{
"from_icd11": "LB21.Z",
"icd10_code": "Q450",
"icd10_title": "Agenesis, aplasia and hypoplasia of pancreas"
},
{
"from_icd11": "LB21.Z",
"icd10_code": "Q38-Q45",
"icd10_title": ""
},
{
"from_icd11": "LB21.Z",
"icd10_code": "Q45",
"icd10_title": "Other congenital malformations of digestive system"
},
{
"from_icd11": "LB21.Z",
"icd10_code": "Q452",
"icd10_title": "Congenital pancreatic cyst"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
}
] |
K8681
|
Exocrine pancreatic insufficiency
|
We report the clinical case of a 63‐year‐old Caucasian Italian housewife, who came to our observation from the emergency room complaining an acute progressive abdominal pain and distension, dyspepsia, nausea, diarrhea, and in the last 2 days rectal passage of blood and mucous. She also referred to recurring palpitation and weakness since 3 months. She presented a severe grade of anemia (Hb 7.4 g/dL) requiring blood transfusion, piastrinopenia, a significantly high level of LDH (554 U/L), and leukocytosis with hypereosinophilia. Blood pressure was 95/60 mm Hg, heart rate 95/min, and Glasgow Coma Scale 15. She had an history of atherosclerotic disease and an acute myocardial infarction with cardiac arrest, undergone double coronary bypass. After that event, a thoracic aortic dissection occurred, so an endovascular prosthesis was positioned. During the long recovery because of an acute cardiac tamponade, she underwent surgery again and a pericardial‐pleural window was made. After 2 weeks, she developed apical right pneumothorax, due to emphysematous bullae rupture, and pneumomediastinum was treated by drainage insertion. On our clinical inspection, the patient presented many millimetric papular lesions and petechiae on the anterior part of the thorax and on the central part of the abdomen. Other similar centimetric lesions could be detected on the anterior surface of both legs and arms. She regularly took anticoagulant and cardioaspirin since the first cardiac surgery. To physical examination, the abdomen was no tractable, with signs of peritonitis. Shallow breathing was evident. Abdominal CT scan revealed free subphrenic air and free fluid, due to a probable perforation of the upper digestive tract, with thickening and edema of the intestinal loops. No air‐fluid levels were seen. Other incidental findings were as follows: two calcific nodules in the right lung (10 and 5 mm diameter max); significant pleural and pericardial effusion; an adenoma‐like lesion in the right adrenal gland (25 mm diameter max) and a similar one in the left adrenal gland (12 mm diameter max); and a small calcific left ovarian cyst. CT scan showed also an exophytic lesion of unclear nature (22 mm diameter max) in the upper pole of the right kidney . Small eccentric thrombotic clots were detected in the suprarenal aorta lumen, without hemodynamic meaning. All these reports were unknown at the previous imaging reports introduced by the patient (chest X‐ray and CT scan; abdomen CT scan, performed about 3 months before). Because of the important pericardial effusion, in consideration of the clinical history a preoperative echocardiogram was needed to study the hemodynamic patient status. It helped us to exclude a cardiac tamponade but also revealed a pericardial effusion with a separation of pericardial layers of 1.5 cm and collapse of the vena cava, likely due to hypovolemia. No ventricular failure was detected. After this assessment of cardiac condition, 3 she was sent to operating room. Despite the preoperative suspicion of gastric perforation, we did not perform a laparoscopic approach because of the high risk of the patient (ASA score 4) and severe grade of anemia and we decided for a midline laparotomy. 4 , 5 , 6 , 7 , 8 At the opening of the abdominal cavity, air and copious quantities of feces came out, as a massive colic perforation and faecalis peritonitis. We detected multiple centimetric perforation areas on the medium transverse colon wall with many millimetric ischemic areas along the entire length of the right colon. Both the mucosa and the sierosa were congested, with a brownish red appearance. All these macroscopic data could lead to an ischemic origin of the perforation. We detected no palpable macroscopic lesions during the exploration, besides the CT scan‐evidenced left ovarian one. Left colon was normal without evidence of stenosis or inflammation. We carried out an extended right colectomy but no ileo‐cholic anastomosis could be done in consideration of the severe sepsis and the associated comorbidities, and we performed a terminal ileostomy. We washed the peritoneal cavity with more than 10 liters of warm saline solution, and we used a direct closure of the abdomen without advanced dressing (eg, Negative Wound Pressure Therapy, NWPT, on open abdomen). After surgical treatment, the patient went to intensive care unit (ICU) for management of septic shock and she received antibiotic therapy with piperacillin + tazobactam, metronidazole, and meropenem. CT scan of the chest and abdomen performed 7 days after surgery showed a bronchopneumonic process with no significant abdominal findings. We transferred the patient to internal medicine unit but she died of heart attack 4 weeks after surgery. Pathological examination revealed an irregular mucosa with ulcerated areas and aphtoid lesions. Histology showed multiple areas of erosions and thinning altered with necrosis zones ending in perforation. Several spherical calcifications were objectivated, mostly in the subserosa and the submucosa, suggestive of calcificated Schistosoma larvae's eggs in advanced involution phase.
| 3.984375
| 0.981445
|
sec[1]/p[0]
|
en
| 0.999997
|
31110726
|
https://doi.org/10.1002/ccr3.2138
|
[
"abdomen",
"scan",
"perforation",
"cardiac",
"pericardial",
"abdominal",
"lesions",
"diameter",
"areas",
"blood"
] |
[
{
"code": "MD81.3",
"title": "Acute abdomen"
},
{
"code": "JA01.0",
"title": "Abdominal pregnancy"
},
{
"code": "ME04.Z",
"title": "Ascites, unspecified"
},
{
"code": "NB51.0&XA3KX0",
"title": "Laceration without foreign body of abdominal wall"
},
{
"code": "NB9Y",
"title": "Other specified injuries to the abdomen, lower back, lumbar spine or pelvis"
},
{
"code": "MB71.Y",
"title": "Other specified clinical findings on diagnostic imaging of central nervous system"
},
{
"code": "NE60",
"title": "Harmful effects of drugs, medicaments or biological substances, not elsewhere classified"
},
{
"code": "JA66.3",
"title": "Abnormal ultrasonic finding on antenatal screening of mother"
},
{
"code": "PB28",
"title": "Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance"
},
{
"code": "PC98",
"title": "Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance"
}
] |
=== ICD-11 CODES FOUND ===
[MD81.3] Acute abdomen
Definition: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases
Also known as: Acute abdomen | acute abdominal pain syndrome | surgical abdomen | abdominal acute syndrome | severe abdomen pain
[JA01.0] Abdominal pregnancy
Definition: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy.
Also known as: Abdominal pregnancy | abdomen pregnancy | intraperitoneal pregnancy
Excludes: Maternal care for viable fetus in abdominal pregnancy | Delivery of viable fetus in abdominal pregnancy
[ME04.Z] Ascites, unspecified
Also known as: Ascites, unspecified | Ascites | abdominal dropsy | hydrops abdominis | ascites NOS
[NB9Y] Other specified injuries to the abdomen, lower back, lumbar spine or pelvis
Also known as: Other specified injuries to the abdomen, lower back, lumbar spine or pelvis | Abdominal wall trauma | Injury of pelvic floor | pelvic floor blunt injury | pelvic floor blunt trauma
[MB71.Y] Other specified clinical findings on diagnostic imaging of central nervous system
Also known as: Other specified clinical findings on diagnostic imaging of central nervous system | Epidural haemorrhage, localised, no generalised mass effect or midline shift | Epidural haemorrhage, confined to a small region in relation to a fracture | Epidural haemorrhage, size less than 1 x 1 x 1 cm, not in relation to a fracture | Epidural haemorrhage, mass effect or midline shift less than 0.5 cm
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
Also known as: Harmful effects of drugs, medicaments or biological substances, not elsewhere classified | drugs, medicaments or biological substances, toxicity not elsewhere classified | adverse drug effects | drug reaction NOS | drug allergy NOS
Excludes: Alcohol intoxication | pathological drug intoxication | hypersensitivity reaction to correctly administered drug
[JA66.3] Abnormal ultrasonic finding on antenatal screening of mother
Definition: A sign characterised by an abnormality detected by ultrasound during an antenatal screening of the mother.
Also known as: Abnormal ultrasonic finding on antenatal screening of mother | antenatal ultrasound scan abnormal
[PB28] Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance
Also known as: Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance | accidental overdose of other or unspecified drug, medicament or biological substance | accidental poisoning by other or unspecified drug, medicament or biological substance | other or unspecified drug, medicament or biological substance taken in error | accidental drug overdose
[PC98] Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance
Also known as: Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance | Intentional self-poisoning by and exposure to other or unspecified drug, medicament or biological substance | Intentional overdose of other or unspecified drug, medicament or biological substance | self-administered overdose by drugs | Intentional self-harm by exposure to or harmful effects of systemic antibiotics
=== GRAPH WALKS ===
--- Walk 1 ---
[MD81.3] Acute abdomen
Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...
--PARENT--> [MD81] Abdominal or pelvic pain
Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....
--EXCLUDES--> [?] Spinal pain
Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine....
--- Walk 2 ---
[MD81.3] Acute abdomen
Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...
--PARENT--> [MD81] Abdominal or pelvic pain
Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....
--EXCLUDES--> [?] Spinal pain
Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine....
--- Walk 3 ---
[JA01.0] Abdominal pregnancy
Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....
--EXCLUDES--> [?] Maternal care for viable fetus in abdominal pregnancy
--PARENT--> [?] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--- Walk 4 ---
[JA01.0] Abdominal pregnancy
Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....
--EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy
Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...
--PARENT--> [?] Other assisted single delivery
--- Walk 5 ---
[ME04.Z] Ascites, unspecified
--PARENT--> [ME04] Ascites
Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...
--PARENT--> [?] Symptoms related to the lower gastrointestinal tract or abdomen
--- Walk 6 ---
[ME04.Z] Ascites, unspecified
--PARENT--> [ME04] Ascites
Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...
--CHILD--> [ME04.0] Fluid in peritoneal cavity
|
[
"[MD81.3] Acute abdomen\n Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...\n --PARENT--> [MD81] Abdominal or pelvic pain\n Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....\n --EXCLUDES--> [?] Spinal pain\n Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine....",
"[MD81.3] Acute abdomen\n Def: A clinical syndrome with acute abdominal pain that is severe, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases...\n --PARENT--> [MD81] Abdominal or pelvic pain\n Def: Pain, an unpleasant distress sensation occurring in varying degrees of severity, received by nerve ending in the abdominal and pelvic region....\n --EXCLUDES--> [?] Spinal pain\n Def: This is a condition characterised by pain felt in the back that usually originates from the muscles, nerves, bones, joints or other structures in the spine....",
"[JA01.0] Abdominal pregnancy\n Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....\n --EXCLUDES--> [?] Maternal care for viable fetus in abdominal pregnancy\n --PARENT--> [?] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....",
"[JA01.0] Abdominal pregnancy\n Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....\n --EXCLUDES--> [?] Delivery of viable fetus in abdominal pregnancy\n Def: A condition caused by the development of a viable fetus to the culmination of the pregnancy period. This condition is characterised by parturition of a viable neonate from the abdominal cavity, at the...\n --PARENT--> [?] Other assisted single delivery",
"[ME04.Z] Ascites, unspecified\n --PARENT--> [ME04] Ascites\n Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...\n --PARENT--> [?] Symptoms related to the lower gastrointestinal tract or abdomen",
"[ME04.Z] Ascites, unspecified\n --PARENT--> [ME04] Ascites\n Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...\n --CHILD--> [ME04.0] Fluid in peritoneal cavity"
] |
MD81.3
|
Acute abdomen
|
[
{
"from_icd11": "MD81.3",
"icd10_code": "R100",
"icd10_title": "Acute abdomen"
},
{
"from_icd11": "JA01.0",
"icd10_code": "O0000",
"icd10_title": "Abdominal pregnancy without intrauterine pregnancy"
},
{
"from_icd11": "JA01.0",
"icd10_code": "O000",
"icd10_title": "Abdominal pregnancy"
},
{
"from_icd11": "ME04.Z",
"icd10_code": "R180",
"icd10_title": "Malignant ascites"
},
{
"from_icd11": "ME04.Z",
"icd10_code": "R18",
"icd10_title": "Ascites"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95A",
"icd10_title": "Adverse effect of other bacterial vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z15A",
"icd10_title": "Adverse effect of immunoglobulin, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z95A",
"icd10_title": "Adverse effect of other vaccines and biological substances, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95S",
"icd10_title": "Adverse effect of other bacterial vaccines, sequela"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B95A",
"icd10_title": "Adverse effect of other viral vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A25A",
"icd10_title": "Adverse effect of mixed bacterial vaccines without a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A91A",
"icd10_title": "Poisoning by other bacterial vaccines, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T498X5A",
"icd10_title": "Adverse effect of other topical agents, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48905A",
"icd10_title": "Adverse effect of unspecified agents primarily acting on the respiratory system, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48995A",
"icd10_title": "Adverse effect of other agents primarily acting on the respiratory system, initial encounter"
}
] |
R100
|
Acute abdomen
|
An 11-year-old female patient presented to the emergency department with progressive bilateral lower limb weakness, more severe on the right side, localized pain, and segmental distribution over one week. She was unable to stand for approximately three days and reported urinary urgency and straining. The patient had no history of trauma, congenital disorders, or familial illnesses, and denied previous surgeries or medication use. Vital signs and blood tests were within normal limits. Physical examination revealed proximal muscle weakness in both lower limbs (2/5 right thigh and 3/5 left thigh), along with hyperactive patellar and achilles reflexes, and decreased abdominal reflexes. Following the physical examination, non-contrast and contrast magnetic resonance imaging (MRI) revealed a tumorous lesion at the level of the D6 and D7 vertebrae, measuring about 4 cm × 4 cm × 5 cm. The lesion showed high signal intensity on T2-weighted images, low signal intensity on T1-weighted images, and heterogeneous enhancement post-contrast image, with erotion of the D6 posterior arch and the right pedicle, causing spinal cord compression. [ Fig. 1 ]. Based upon the neurologic symptomatology and radiological findings, surgical excision was recommended, with the patient's consent obtained and medical consultations prior to the procedure revealing no objections. The surgery was performed two days after imaging. A neurosurgery specialist performed tumor resection, revealing the mass to be fragile, bleeding, and highly vascularized from a subcostal artery, eroding the bone [ Fig. 2 ]. Spinal stabilization was achieved using eight pedicle screws, rods, and a bridge, with cervical screws employed due to the unavailability of pediatric screws [ Fig. 3 ]. Regarding the difficulties in using screws in the child, the decision was challenging due to the unavailability of pediatric-specific screws. Cervical screws were used and reinforced with adult-sized fixation rods using a connecting device. In addition, there were numerous anatomical challenges during the child's surgery, including the need to minimize bleeding, the mismatch between the size of surgical instruments and the child's size, the small size of muscle mass and bony elements, and the proximity of anatomical structures, which posed challenges during fixation. A biopsy of the tumor was taken after excision and sent for pathological examination, which showed bone trabeculae and a tumor comprised mainly of multinucleated giant osteoclasts and spindle-shaped mononuclear macrophage-like cells. The stroma contains blood vessels and diffuse hemorrhagic regions, with no signs of sarcomatous change [ Fig. 4 ]. Differential diagnosis initially raised suspicion of spinal tuberculosis, which was excluded by histopathological examination. Based on the aforementioned histological findings, the diagnosis of GCT in the seventh thoracic vertebra was made. Postoperatively, the patient received dexamethasone at a dosage of 2.5 mg twice daily (0.15 mg/kg based on a weight of 35 kg). Within 48 h, a significant muscle strength improvement was observed, enabling ambulation with assistance and the commencement of early physical therapy. One week post-discharge, the patient ambulated independently with full bladder control. Sutures were removed after two weeks, with continued physical therapy, and The patient was followed up after one and three months, respectively, with a normal neurological examination and no complications, recurrence of the tumor, or need for further intervention. An MRI was performed after six months as a follow-up, which was normal. Fig. 1 Non-contrast (images A, B, and C) and contrast (image D) magnetic resonance imaging revealed a tumorous lesion at the level of the D6 and D7 vertebrae, measuring about 4 cm × 4 cm × 5 cm. The lesion showed high signal intensity on T2-weighted images, low signal intensity on T1-weighted images, and heterogeneous enhancement post-contrast image, with erotion of the D6 posterior arch and the right pedicle, causing spinal cord compression. (A: Sagittal section of T1-weighted sequence, B: Axial section of T2-weighted sequence, C: Sagittal section of T2-weighted sequence, D: Sagittal section of T1-weighted sequence). Fig. 1 Fig. 2 Intraoperative images demonstrate that the lesion eroded the right lamina, facet joint, and rib junction (image B). Following complete tumor resection, a defect in the vertebral body was visibled, with the spinal cord having been relieved from compression (image A). Fig. 2 Fig. 3 Anteroposterior (image B) and lateral (image A) X-rays of the thoracic spine reveal a transpedicular fixation device comprising eight pedicle screws at T5, T6, T8, and T9 levels, along with connectors and four rods. Lateral mass screws were utilized due to the unavailability of pediatric devices. Fig. 3 Fig. 4 Histological examination showed bone trabecula and a tumor comprised mainly of multinucleated giant osteoclasts and spindle-shaped mononuclear macrophage-like cells. The stroma contains blood vessels and diffuse hemorrhagic regions, with no signs of sarcomatous change. Fig. 4
| 4.011719
| 0.978027
|
sec[0]/p[3]
|
en
| 0.999997
|
39813982
|
https://doi.org/10.1016/j.ijscr.2025.110890
|
[
"weighted",
"screws",
"contrast",
"tumor",
"lesion",
"spinal",
"physical",
"signal",
"intensity",
"pedicle"
] |
[
{
"code": "MG43.5",
"title": "Excessive weight loss"
},
{
"code": "MG43.6",
"title": "Excessive weight gain"
},
{
"code": "MG44.11",
"title": "Failure to thrive in infant or child"
},
{
"code": "5B80.0Z",
"title": "Overweight, unspecified"
},
{
"code": "JA65.2",
"title": "Excessive weight gain in pregnancy"
},
{
"code": "QB84",
"title": "Follow-up care involving removal of fracture plate or other internal fixation device"
},
{
"code": "DA21.20",
"title": "Hypertensive peristalsis"
},
{
"code": "PK99.3",
"title": "Orthopaedic devices associated with injury or harm, surgical instruments, materials or devices"
},
{
"code": "9D43",
"title": "Impairment of contrast vision"
},
{
"code": "QA00.6Y",
"title": "Other specified examination of eyes or vision"
}
] |
=== ICD-11 CODES FOUND ===
[MG43.5] Excessive weight loss
Definition: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health.
Also known as: Excessive weight loss | abnormal decrease in weight | abnormal weight loss | unintended weight loss | weight loss NOS
[MG43.6] Excessive weight gain
Definition: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantity or rate to create risk to the individual’s health.
Also known as: Excessive weight gain | abnormal increase in weight | abnormal weight gain | unintended weight gain
Excludes: Obesity
[MG44.11] Failure to thrive in infant or child
Definition: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender.
Also known as: Failure to thrive in infant or child | failure to gain weight | failure to thrive NOS | FTT - [failure to thrive] syndrome
Excludes: Failure to thrive in newborn | Anorexia Nervosa | Avoidant-restrictive food intake disorder
[5B80.0Z] Overweight, unspecified
Also known as: Overweight, unspecified | Overweight
[JA65.2] Excessive weight gain in pregnancy
Definition: Any reason for encounter to assess (or care for) a mother for excessive weight gain during pregnancy.
Also known as: Excessive weight gain in pregnancy | excessive weight gain in pregnancy, unspecified trimester | maternal obesity syndrome | maternal obesity without hypertension | abnormal weight gain in pregnancy
Excludes: Gestational oedema without hypertension
[QB84] Follow-up care involving removal of fracture plate or other internal fixation device
Also known as: Follow-up care involving removal of fracture plate or other internal fixation device | Change of internal fixation device | change of fixation device | change of Kirschner wire | Checking of internal fixation device
Excludes: removal of external fixation device
[DA21.20] Hypertensive peristalsis
Definition: This is a motility disorder of oesophagus characterised by hypertensive peristalsis. This motility abnormality includes nutcracker oesophagus that has been reported in association with dysphagia, non-cardiac chest pain, and heartburn.
Also known as: Hypertensive peristalsis | Bársony-Polgár Syndrome II | corkscrew oesophagus | curling of oesophagus | Nutcracker oesophagus
[PK99.3] Orthopaedic devices associated with injury or harm, surgical instruments, materials or devices
Definition: Orthopaedic related surgical instruments like materials and devices (including sutures) were involved in an adverse related incident
Also known as: Orthopaedic devices associated with injury or harm, surgical instruments, materials or devices | Orthopaedic devices associated with injury or harm, suture material | Orthopaedic devices associated with injury or harm, scalpel | Orthopaedic devices associated with injury or harm, cautery device | Orthopaedic devices associated with injury or harm, laser
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
[9D43] Impairment of contrast vision
Definition: Contrast sensitivity refers to the ability to distinguish small differences in brightness between adjacent surfaces.
Peak Contrast sensitivity refers to the smallest differences that are discernible for large stimuli.
For smaller objects, such as those involved in many Activities of Daily Living, contrast sensitivity interacts with visual acuity and visual field. Better contrast makes smaller details visible. The visual field is larger for stronger stimuli.
Also known as: Impairment of contrast vision | Moderate impairment of contrast vision | Profound impairment of contrast vision
[QA00.6Y] Other specified examination of eyes or vision
Also known as: Other specified examination of eyes or vision | No Impairment of Contrast vision | Normal colour vision | No Impairment of Dark adaptation | No diplopia
=== GRAPH WALKS ===
--- Walk 1 ---
[MG43.5] Excessive weight loss
Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....
--PARENT--> [MG43] Symptoms or signs concerning food or fluid intake
Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...
--EXCLUDES--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--- Walk 2 ---
[MG43.5] Excessive weight loss
Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....
--PARENT--> [MG43] Symptoms or signs concerning food or fluid intake
Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...
--EXCLUDES--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--- Walk 3 ---
[MG43.6] Excessive weight gain
Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...
--EXCLUDES--> [?] Obesity
Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...
--CHILD--> [?] Obesity due to energy imbalance
Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...
--- Walk 4 ---
[MG43.6] Excessive weight gain
Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...
--EXCLUDES--> [?] Obesity
Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...
--CHILD--> [?] Obesity due to energy imbalance
Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...
--- Walk 5 ---
[MG44.11] Failure to thrive in infant or child
Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....
--EXCLUDES--> [?] Failure to thrive in newborn
Def: When newborn’s current weight or rate of weight gain is significantly below that of other newborns of similar age and gender....
--PARENT--> [?] Feeding problems of newborn
Def: A lack of interest in feeding or a problem receiving the proper amount of nutrition in a newborn....
--- Walk 6 ---
[MG44.11] Failure to thrive in infant or child
Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....
--EXCLUDES--> [?] Anorexia Nervosa
Def: Anorexia Nervosa is characterised by significantly low body weight for the individual’s height, age and developmental stage that is not due to another health condition or to the unavailability of food...
--CHILD--> [?] Anorexia Nervosa in recovery with normal body weight
Def: Among individuals who are recovering from Anorexia Nervosa and whose body weight is more than 18.5 kg/m2 for adults or over the fifth percentile for BMI-for-age for children and adolescents, the diagn...
|
[
"[MG43.5] Excessive weight loss\n Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....\n --PARENT--> [MG43] Symptoms or signs concerning food or fluid intake\n Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...\n --EXCLUDES--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...",
"[MG43.5] Excessive weight loss\n Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....\n --PARENT--> [MG43] Symptoms or signs concerning food or fluid intake\n Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...\n --EXCLUDES--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...",
"[MG43.6] Excessive weight gain\n Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...\n --EXCLUDES--> [?] Obesity\n Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...\n --CHILD--> [?] Obesity due to energy imbalance\n Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...",
"[MG43.6] Excessive weight gain\n Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...\n --EXCLUDES--> [?] Obesity\n Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...\n --CHILD--> [?] Obesity due to energy imbalance\n Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...",
"[MG44.11] Failure to thrive in infant or child\n Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....\n --EXCLUDES--> [?] Failure to thrive in newborn\n Def: When newborn’s current weight or rate of weight gain is significantly below that of other newborns of similar age and gender....\n --PARENT--> [?] Feeding problems of newborn\n Def: A lack of interest in feeding or a problem receiving the proper amount of nutrition in a newborn....",
"[MG44.11] Failure to thrive in infant or child\n Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....\n --EXCLUDES--> [?] Anorexia Nervosa\n Def: Anorexia Nervosa is characterised by significantly low body weight for the individual’s height, age and developmental stage that is not due to another health condition or to the unavailability of food...\n --CHILD--> [?] Anorexia Nervosa in recovery with normal body weight\n Def: Among individuals who are recovering from Anorexia Nervosa and whose body weight is more than 18.5 kg/m2 for adults or over the fifth percentile for BMI-for-age for children and adolescents, the diagn..."
] |
MG43.5
|
Excessive weight loss
|
[
{
"from_icd11": "MG43.5",
"icd10_code": "R634",
"icd10_title": "Abnormal weight loss"
},
{
"from_icd11": "MG43.6",
"icd10_code": "R635",
"icd10_title": "Abnormal weight gain"
},
{
"from_icd11": "5B80.0Z",
"icd10_code": "E669",
"icd10_title": "Obesity, unspecified"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2603",
"icd10_title": "Excessive weight gain in pregnancy, third trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2601",
"icd10_title": "Excessive weight gain in pregnancy, first trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2602",
"icd10_title": "Excessive weight gain in pregnancy, second trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O260",
"icd10_title": "Excessive weight gain in pregnancy"
},
{
"from_icd11": "QB84",
"icd10_code": "Z4733",
"icd10_title": "Aftercare following explantation of knee joint prosthesis"
},
{
"from_icd11": "QB84",
"icd10_code": "Z4732",
"icd10_title": "Aftercare following explantation of hip joint prosthesis"
},
{
"from_icd11": "QB84",
"icd10_code": "Z472",
"icd10_title": "Encounter for removal of internal fixation device"
},
{
"from_icd11": "QB84",
"icd10_code": "Z471",
"icd10_title": "Aftercare following joint replacement surgery"
},
{
"from_icd11": "QB84",
"icd10_code": "Z4731",
"icd10_title": "Aftercare following explantation of shoulder joint prosthesis"
},
{
"from_icd11": "QB84",
"icd10_code": "Z4781",
"icd10_title": "Encounter for orthopedic aftercare following surgical amputation"
},
{
"from_icd11": "QB84",
"icd10_code": "Z4789",
"icd10_title": "Encounter for other orthopedic aftercare"
},
{
"from_icd11": "QB84",
"icd10_code": "Z47",
"icd10_title": "Orthopedic aftercare"
}
] |
R634
|
Abnormal weight loss
|
We present the case of a 79-year-old male patient, who is admitted to our center for endoprosthetic orthopedic surgery of St. Vincenz-Hospital, Menden, Germany. The patient is admitted with a 5-day history of pain, swelling, and motility disorder of the right knee. The medical history of the patient included polyarthritis rheumatica, obstructive sleep apnea syndrome, pacemaker implantation (Biotronik Talos DR) in 2005 for atrial fibrillation, condition after angioplasty for coronary disease , degenerative disc disease, obesity, antral gastritis, endoscopic Zenker's diverticulum repair performed in 2014, and uncontrolled type 2 diabetes. The surgical history of the patient included sigma resection for complicated diverticulitis with hemorrhage in 2004 and the substrate of our case represented by the presence of a right bicondylar knee replacement surgery, which was performed due to gonarthrosis 17 years ago. On clinical examination we suspected a local infection due to the presence of the Celsian clinical features for acute inflammation, represented by pain, swelling, local heat, erythema, and movement disorder with partial loss of function (functio laesa). The radiographies of the right knee revealed no signs of displacement, loosening of the prothesis, or other pathological signs which would include unsealing, fracture, or cortical bone modifications. Without the presence of SIRS (Systemic Inflammatory Response Syndrome) that collection of blood cultures is unnecessary and we decided to aspirate the knee joint. A seropurulent fluid is extracted and sent for microbiological examination. A Bruker MALDI-TOF Biotyper was used and the result showed us the presence of isolated Lactococcus garvieae , which according to the antibiogram showed susceptibility to Erythromycin, Cefazolin, Cefuroxime, Cefotaxime, Imipenem, Meropenem, Ertapenem, and Linezolid. Correlating our findings, clinically, microbiologically, and with the pathological modified laboratory data, which included a leukocyte count of 10.4/nL (normal range: 4.0–10.0), creatinine: 1.4 mg/dL (normal range: 0.00–1.20), and a C-reactive protein of 12.5 mg/dL (normal range < 0.50), we decided to institute an intravenous therapy with Cefazolin 2 g for every 8 hours. After 6 days without a remarkably improvement of the symptoms or of the joint motility, we performed an exploratory arthroscopy of the affected joint. During the arthroscopic lavage, partial synovectomy was performed. Furthermore 4 samples have been taken and sent for culture and microbiological examinations. For the postoperative secretion control we placed 2 Redon drains in the knee joint. The microbiological report from the medial synovial membrane showed no bacterial growth, but the examination of the sample taken from the upper recess of the knee and from the synovial fluid confirmed once again the infection with Lactococcus garvieae . After 11 more days of Cefazolin therapy, the laboratory findings have shown a satisfactory decrease of the C-reactive protein to a value of 2.92 mg/dL, contrary to the clinical findings, which showed the persistence of swelling, pain, and motility disorder. Based on the constellation of the clinical and laboratory findings we decided that an open revision surgery of the knee is rational. The intraoperative findings revealed a partially delaminated inlay which required no urgent replacement and an inflamed synovia. The quadriceps and patellar tendons were intact and had no role in the etiology of the motility disorder of the knee joint. Under these circumstances we decided to take samples again, perform a synovial resection, jet lavage joint cleansing, and debridement, and use a vacuum-assisted negative pressure wound closure therapy system (V.A.C-Ulta™ Therapy). The microbiological analyses of the samples have attested once more the presence of Lactococcus garvieae and a third surgical procedure was performed 6 days later in the context of revision surgery. During the procedure we did probe preservation, joint lavage, and the change of the V.A.C-Ulta system. During this period of time the patient had received without disruption the initial intravenous antibiotic therapy with Cefazolin. The latest microbiological findings showed no growth of Lactococcus garvieae and we decided after 10 days from the last surgery to remove the V.A.C-Ulta system and to perform probe preservation, drainage, and secondary wound closure. After 2 days we removed the drains and sent the intra-articular part of the Redon tubes for microbiological analysis. The results were negative for infection and after physiotherapy combined with continuous passive motion (CPM) the patient managed to improve his right knee range of motion to 0/0/95 degrees. After 44 days of therapy (24 days with Cefazolin antibiotic therapy) we managed to discharge the patient with no signs of infection and with satisfactory joint mobility. At the follow-up controls at 2, 4, and 6 weeks after discharge, evidences of recurrence infection were not present. With further unaffected joint motility, our patient remains satisfied with the therapeutic outcomes.
| 4.023438
| 0.975586
|
sec[1]/p[0]
|
en
| 0.999996
|
27833769
|
https://doi.org/10.1155/2016/5053640
|
[
"knee",
"joint",
"which",
"microbiological",
"motility",
"presence",
"infection",
"decided",
"cefazolin",
"lactococcus"
] |
[
{
"code": "FA2Z",
"title": "Inflammatory arthropathies, unspecified"
},
{
"code": "NC90.Y",
"title": "Other specified superficial injury of knee or lower leg"
},
{
"code": "FA34.4",
"title": "Ankylosis of joint"
},
{
"code": "FA33.4Z",
"title": "Chronic instability of knee, unspecified"
},
{
"code": "NC90.0",
"title": "Abrasion of knee"
},
{
"code": "FA5Z",
"title": "Arthropathies, unspecified"
},
{
"code": "FA36.Z",
"title": "Effusion of joint, unspecified"
},
{
"code": "FA37.Y",
"title": "Other specified certain joint disorders, not elsewhere classified"
},
{
"code": "FA34.3",
"title": "Contracture of joint"
},
{
"code": "BD50.41",
"title": "Abdominal aortic aneurysm with rupture"
}
] |
=== ICD-11 CODES FOUND ===
[FA2Z] Inflammatory arthropathies, unspecified
Also known as: Inflammatory arthropathies, unspecified | polyarthritis NOS | inflammatory joint disease NOS | nonpyogenic arthritis NOS | arthritic nodosa
[NC90.Y] Other specified superficial injury of knee or lower leg
Also known as: Other specified superficial injury of knee or lower leg | Nonthermal blister of other or unspecified parts of lower leg | Nonvenomous insect bite of other or unspecified parts of lower leg | Superficial foreign body in other or unspecified parts of lower leg | Splinter in other or unspecified parts of lower leg
[FA34.4] Ankylosis of joint
Definition: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition.
Also known as: Ankylosis of joint | ankylosis | ankylosis of joint, site unspecified | frozen joint | fusion of joint
Excludes: stiffness of joint without ankylosis | Ankylosis of spinal joint
[FA33.4Z] Chronic instability of knee, unspecified
Also known as: Chronic instability of knee, unspecified | Chronic instability of knee | instability of knee | old disruption of ligament of knee
[NC90.0] Abrasion of knee
Also known as: Abrasion of knee
[FA5Z] Arthropathies, unspecified
Also known as: Arthropathies, unspecified | Disorders affecting predominantly peripheral joints | Disorders affecting predominantly peripheral limb joints | arthropathy NOS | arthropathic
[FA36.Z] Effusion of joint, unspecified
Also known as: Effusion of joint, unspecified | Effusion of joint | effusion into joint | effusion of joint, site unspecified | hydrarthrosis
[FA37.Y] Other specified certain joint disorders, not elsewhere classified
Also known as: Other specified certain joint disorders, not elsewhere classified | Calcification of joint | Periarticular calcification | Periarticular ossification | Fistula of joint
[FA34.3] Contracture of joint
Also known as: Contracture of joint | contracture of joint, site unspecified | joint contraction | joint contracture | abduction contracture joint
Excludes: Dupuytren contracture | contracture of tendon (sheath) without contracture of joint | acquired deformities of limbs
[BD50.41] Abdominal aortic aneurysm with rupture
Also known as: Abdominal aortic aneurysm with rupture | abdominal aorta aneurysm rupture | abdominal aorta aneurysm ruptured | abdominal aortic aneurysm which has ruptured | ruptured AAA
=== GRAPH WALKS ===
--- Walk 1 ---
[FA2Z] Inflammatory arthropathies, unspecified
--PARENT--> [?] Inflammatory arthropathies
--CHILD--> [FA20] Rheumatoid arthritis
Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...
--- Walk 2 ---
[FA2Z] Inflammatory arthropathies, unspecified
--PARENT--> [?] Inflammatory arthropathies
--CHILD--> [FA21] Psoriatic arthritis
Def: Psoriatic arthritis, a member of the spondyloarthritis family, is defined as an inflammatory arthropathy associated with psoriasis that is usually rheumatic factor negative. It is characterised by var...
--- Walk 3 ---
[NC90.Y] Other specified superficial injury of knee or lower leg
--PARENT--> [NC90] Superficial injury of knee or lower leg
--EXCLUDES--> [?] Superficial injury of ankle or foot
--- Walk 4 ---
[NC90.Y] Other specified superficial injury of knee or lower leg
--PARENT--> [NC90] Superficial injury of knee or lower leg
--CHILD--> [NC90.2] Abrasion of other or unspecified parts of lower leg
--- Walk 5 ---
[FA34.4] Ankylosis of joint
Def: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition....
--EXCLUDES--> [?] Stiffness of joint
Def: Lack of range of motion of a joint secondary to pain, disease process or congenital malformation not detailed in or used in conjunction with other codes....
--PARENT--> [?] Certain joint disorders, not elsewhere classified
--- Walk 6 ---
[FA34.4] Ankylosis of joint
Def: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition....
--EXCLUDES--> [?] Ankylosis of spinal joint
--CHILD--> [?] Ankylosis of cervical spinal joint
|
[
"[FA2Z] Inflammatory arthropathies, unspecified\n --PARENT--> [?] Inflammatory arthropathies\n --CHILD--> [FA20] Rheumatoid arthritis\n Def: Rheumatoid arthritis (RA) is persistent and/or erosive disease that is defined as the confirmed presence of synovitis in at least 1 joint, absence of an alternative diagnosis that better explains the ...",
"[FA2Z] Inflammatory arthropathies, unspecified\n --PARENT--> [?] Inflammatory arthropathies\n --CHILD--> [FA21] Psoriatic arthritis\n Def: Psoriatic arthritis, a member of the spondyloarthritis family, is defined as an inflammatory arthropathy associated with psoriasis that is usually rheumatic factor negative. It is characterised by var...",
"[NC90.Y] Other specified superficial injury of knee or lower leg\n --PARENT--> [NC90] Superficial injury of knee or lower leg\n --EXCLUDES--> [?] Superficial injury of ankle or foot",
"[NC90.Y] Other specified superficial injury of knee or lower leg\n --PARENT--> [NC90] Superficial injury of knee or lower leg\n --CHILD--> [NC90.2] Abrasion of other or unspecified parts of lower leg",
"[FA34.4] Ankylosis of joint\n Def: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition....\n --EXCLUDES--> [?] Stiffness of joint\n Def: Lack of range of motion of a joint secondary to pain, disease process or congenital malformation not detailed in or used in conjunction with other codes....\n --PARENT--> [?] Certain joint disorders, not elsewhere classified",
"[FA34.4] Ankylosis of joint\n Def: The term ankylosis denotes restricted movement in the joint, and it can be bony or fibrous. Most cases are caused by trauma, infection, radiotherapy, or severe arthritic condition....\n --EXCLUDES--> [?] Ankylosis of spinal joint\n --CHILD--> [?] Ankylosis of cervical spinal joint"
] |
FA2Z
|
Inflammatory arthropathies, unspecified
|
[
{
"from_icd11": "FA2Z",
"icd10_code": "M1389",
"icd10_title": "Other specified arthritis, multiple sites"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M1380",
"icd10_title": "Other specified arthritis, unspecified site"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13862",
"icd10_title": "Other specified arthritis, left knee"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13872",
"icd10_title": "Other specified arthritis, left ankle and foot"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13871",
"icd10_title": "Other specified arthritis, right ankle and foot"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13861",
"icd10_title": "Other specified arthritis, right knee"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13879",
"icd10_title": "Other specified arthritis, unspecified ankle and foot"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13842",
"icd10_title": "Other specified arthritis, left hand"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13841",
"icd10_title": "Other specified arthritis, right hand"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13811",
"icd10_title": "Other specified arthritis, right shoulder"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13162",
"icd10_title": "Monoarthritis, not elsewhere classified, left knee"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13869",
"icd10_title": "Other specified arthritis, unspecified knee"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M1388",
"icd10_title": "Other specified arthritis, other site"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13171",
"icd10_title": "Monoarthritis, not elsewhere classified, right ankle and foot"
},
{
"from_icd11": "FA2Z",
"icd10_code": "M13152",
"icd10_title": "Monoarthritis, not elsewhere classified, left hip"
}
] |
M1389
|
Other specified arthritis, multiple sites
|
She ultimately was able to achieve full remission from BED over the course of 6 months, reporting significant reduction in overvaluation of her shape and weight, a sense of self-efficacy around eating flexibly, finding forms of physical movement that she enjoyed and were not compulsive, and maintaining weight around the 90th percentile. She preferred not to engage in many common body image-related skills, instead prioritizing other values (e.g., relationships and education), a focus of CBT-E. Other modalities were also drawn from to further strengthen her connection with these aspects of identity (Mindfulness-Based Self-Compassion and Acceptance and Commitment Therapy). Thus, she did not participate in many behavioral activities included within CBT-E, an adaptation that was agreed upon to empower Eva to make informed decisions about her treatment goals. Table 1 Experiences, challenges, and adaptations made during ED treatment to respond to weight stigma Megan Emily Eva Etiology • Weight-based teasing; bullying • Internalized weight bias contributed to restriction, purging (self-induced vomiting, laxative misuse), binge eating, chewing and spitting • Preference for foods parents considered “unhealthy” • Significant physical activity despite low weight • Weight-based teasing; comments about body size by caregivers and peers • Internalized weight bias contributing to restriction and exercise Diagnosis and Assessment • Delayed ED diagnosis related to size/weight bias within assessment practices (i.e., SCOFF, PCP visit), despite high weight suppression • Parents and doctors unconcerned about chronic poor nourishment and low weight, delaying diagnosis of ARFID • Athlete status contributed to reduced concern about low weight • Not observed Medical Care and ED treatment • Delayed referral to specialized ED care • Early discharge from residential ED treatment due to insurance denying coverage related to weight-bias embedded within policies • Continued encouragement to “eat healthy” and lose weight before and after treatment • Disagreement between caregivers and medical providers regarding increasing caloric intake and weight goal • Anxiety about transgressing family’s food-related values and becoming “unhealthy” • Terminated care at 55th BMI%ile despite historically tracking at 89th BMI%ile • 1.5 years following completion of FBT, relapse into restriction and exercise following weight gain Family and Peer Response • When expressed distress about weight, shape, and size, family encouraged exercise and healthy eating as means to change body composition • Caregivers equating health and morality with being “thin and fit” • Culturally normative terms of endearment were experienced by patient as distressing • Focus on eating “healthy foods” • Comments about not eating “too much” when trying to prevent binge eating • Parent attempted to restrict access to certain foods to prevent weight gain and distress related to binge eating Clinical Challenges • In-session weighing distressing • Reaching TGW “shocking” to patient, who reported feeling that she was not “sick” enough • Ongoing body dissatisfaction challenging to address given bullying and stigma • Continued avoidance of social activities involving movement (e.g., sports) • Patient and caregivers experienced anxiety related to weight gain in treatment • Patient reported weight gain conflicted with family's’ identified values • Difficulty understanding “flexible eating” in the context of ARFID treatment • FBT was concluded while patient remained weight-suppressed, given patient demonstrated little distress and eating was normalized • Patient unwilling to know weight or participate in body image exposures • Interaction of stigmatizing experiences, cultural identity, experiences of minority stress, trauma, internalized weight bias, and disordered eating Modifications to address weight stigma during treatment • Blind weighing • Shift from FBT to CBT-E due to ongoing and persistent body dissatisfaction • Addition of psychoeducation on body diversity and weight stigma • Psychoeducation on weight stigma to address caregiver concern for "unhealthy” foods being accepted for meals • Blind weighing • Avoided body image-related exposures and focused on values over changing body image • Incorporating weight stigma in CBT-E formulation • Psychoeducation about weight stigma and HAES • Self-compassion to mitigate internalized weight stigma • Trauma-informed formulation of ED and interventions Recovery • Negative comments by peers and adults about food choices • Continued messages from medical providers about weight and diet • Not observed • Confusion around TGW and not enforcing weight gain beyond mBMI, despite a higher historical weight • Reluctance to gain further weight upon first admission Note: ARFID = avoidant restrictive food intake disorder; BMI = body mass index; CBT-E = Enhanced Cognitive Behavior Therapy; ED = eating disorder; FBT = Family-Based Treatment; HAES = Health at Every Size; PCP = primary care physician; SCOFF = Sick-Control-One Stone-Fat-Food Assessment for Eating Disorders; TGW = treatment goal weight
| 4.160156
| 0.832031
|
sec[7]/sec[2]/p[1]
|
en
| 0.999997
|
39485638
|
https://doi.org/10.1007/s10802-024-01260-3
|
[
"weight",
"eating",
"body",
"about",
"stigma",
"related",
"gain",
"bias",
"family",
"self"
] |
[
{
"code": "MG43.5",
"title": "Excessive weight loss"
},
{
"code": "MG43.6",
"title": "Excessive weight gain"
},
{
"code": "MG44.11",
"title": "Failure to thrive in infant or child"
},
{
"code": "5B80.0Z",
"title": "Overweight, unspecified"
},
{
"code": "JA65.2",
"title": "Excessive weight gain in pregnancy"
},
{
"code": "6B8Z",
"title": "Feeding or eating disorders, unspecified"
},
{
"code": "MG43.1",
"title": "Overeating"
},
{
"code": "MG43.40",
"title": "Refusal of food, not elsewhere classified"
},
{
"code": "MG43.Y",
"title": "Other specified symptoms or signs concerning food or fluid intake"
},
{
"code": "6B8Y",
"title": "Other specified feeding or eating disorders"
}
] |
=== ICD-11 CODES FOUND ===
[MG43.5] Excessive weight loss
Definition: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health.
Also known as: Excessive weight loss | abnormal decrease in weight | abnormal weight loss | unintended weight loss | weight loss NOS
[MG43.6] Excessive weight gain
Definition: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantity or rate to create risk to the individual’s health.
Also known as: Excessive weight gain | abnormal increase in weight | abnormal weight gain | unintended weight gain
Excludes: Obesity
[MG44.11] Failure to thrive in infant or child
Definition: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender.
Also known as: Failure to thrive in infant or child | failure to gain weight | failure to thrive NOS | FTT - [failure to thrive] syndrome
Excludes: Failure to thrive in newborn | Anorexia Nervosa | Avoidant-restrictive food intake disorder
[5B80.0Z] Overweight, unspecified
Also known as: Overweight, unspecified | Overweight
[JA65.2] Excessive weight gain in pregnancy
Definition: Any reason for encounter to assess (or care for) a mother for excessive weight gain during pregnancy.
Also known as: Excessive weight gain in pregnancy | excessive weight gain in pregnancy, unspecified trimester | maternal obesity syndrome | maternal obesity without hypertension | abnormal weight gain in pregnancy
Excludes: Gestational oedema without hypertension
[6B8Z] Feeding or eating disorders, unspecified
Also known as: Feeding or eating disorders, unspecified | Eating disorder, not elsewhere classified | eating disorder NOS
[MG43.1] Overeating
Definition: The consumption of excess food in relation to energy and nutritional requirements.
Also known as: Overeating | Excessive eating | gluttony | hyperalimentation | Hyperalimentation NOS
Includes: Excessive eating
Excludes: Bipolar or related disorders | Depressive disorders | Feeding or eating disorders
[MG43.40] Refusal of food, not elsewhere classified
Also known as: Refusal of food, not elsewhere classified | stopped eating | refusal to eat
Excludes: Intentional self-harm by lack of food | Anorexia
[MG43.Y] Other specified symptoms or signs concerning food or fluid intake
Also known as: Other specified symptoms or signs concerning food or fluid intake | Eating problem in child
[6B8Y] Other specified feeding or eating disorders
Also known as: Other specified feeding or eating disorders
=== GRAPH WALKS ===
--- Walk 1 ---
[MG43.5] Excessive weight loss
Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....
--PARENT--> [MG43] Symptoms or signs concerning food or fluid intake
Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...
--EXCLUDES--> [?] Undernutrition
Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...
--- Walk 2 ---
[MG43.5] Excessive weight loss
Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....
--PARENT--> [MG43] Symptoms or signs concerning food or fluid intake
Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...
--CHILD--> [MG43.1] Overeating
Def: The consumption of excess food in relation to energy and nutritional requirements....
--- Walk 3 ---
[MG43.6] Excessive weight gain
Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...
--RELATED_TO--> [?] Excessive weight gain in pregnancy
Def: Any reason for encounter to assess (or care for) a mother for excessive weight gain during pregnancy....
--PARENT--> [?] Maternal care for other conditions predominantly related to pregnancy
Def: Any reason for encounter to assess (or care for) a mother for other conditions predominantly related to pregnancy....
--- Walk 4 ---
[MG43.6] Excessive weight gain
Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...
--EXCLUDES--> [?] Obesity
Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...
--CHILD--> [?] Drug-induced obesity
--- Walk 5 ---
[MG44.11] Failure to thrive in infant or child
Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....
--EXCLUDES--> [?] Anorexia Nervosa
Def: Anorexia Nervosa is characterised by significantly low body weight for the individual’s height, age and developmental stage that is not due to another health condition or to the unavailability of food...
--EXCLUDES--> [?] Anorexia
Def: Anorexia is a pathological lack or loss of appetite....
--- Walk 6 ---
[MG44.11] Failure to thrive in infant or child
Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....
--EXCLUDES--> [?] Avoidant-restrictive food intake disorder
Def: Avoidant-restrictive food intake disorder (ARFID) is characterised by avoidance or restriction of food intake that results in: 1) the intake of an insufficient quantity or variety of food to meet adeq...
--PARENT--> [?] Feeding or eating disorders
Def: Feeding and Eating Disorders involve abnormal eating or feeding behaviours that are not explained by another health condition and are not developmentally appropriate or culturally sanctioned. Feeding ...
|
[
"[MG43.5] Excessive weight loss\n Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....\n --PARENT--> [MG43] Symptoms or signs concerning food or fluid intake\n Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...\n --EXCLUDES--> [?] Undernutrition\n Def: Undernutrition is a condition in which the body’s requirements are unmet due to underconsumption or to impaired absorption and use of nutrients. It can be produced by lack of access to food, or as a c...",
"[MG43.5] Excessive weight loss\n Def: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health....\n --PARENT--> [MG43] Symptoms or signs concerning food or fluid intake\n Def: Symptoms or signs concerning food and fluid intake include anorexia, polydipsia, polyphagia, feeding difficulties or mismanagement, abnormal weight loss, abnormal weight gain, insufficient intake of f...\n --CHILD--> [MG43.1] Overeating\n Def: The consumption of excess food in relation to energy and nutritional requirements....",
"[MG43.6] Excessive weight gain\n Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...\n --RELATED_TO--> [?] Excessive weight gain in pregnancy\n Def: Any reason for encounter to assess (or care for) a mother for excessive weight gain during pregnancy....\n --PARENT--> [?] Maternal care for other conditions predominantly related to pregnancy\n Def: Any reason for encounter to assess (or care for) a mother for other conditions predominantly related to pregnancy....",
"[MG43.6] Excessive weight gain\n Def: An increase in total body mass, due to increase in fluid, fat or adipose tissue, or lean (muscle) mass that is outside the expected range for normal growth and development and is sufficient in quantit...\n --EXCLUDES--> [?] Obesity\n Def: Obesity is a chronic complex disease defined by excessive adiposity that can impair health. It is in most cases a multifactorial disease due to obesogenic environments, psycho-social factors and genet...\n --CHILD--> [?] Drug-induced obesity",
"[MG44.11] Failure to thrive in infant or child\n Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....\n --EXCLUDES--> [?] Anorexia Nervosa\n Def: Anorexia Nervosa is characterised by significantly low body weight for the individual’s height, age and developmental stage that is not due to another health condition or to the unavailability of food...\n --EXCLUDES--> [?] Anorexia\n Def: Anorexia is a pathological lack or loss of appetite....",
"[MG44.11] Failure to thrive in infant or child\n Def: When an infant or child's current weight or rate of weight gain is significantly below that of other children of similar age and gender....\n --EXCLUDES--> [?] Avoidant-restrictive food intake disorder\n Def: Avoidant-restrictive food intake disorder (ARFID) is characterised by avoidance or restriction of food intake that results in: 1) the intake of an insufficient quantity or variety of food to meet adeq...\n --PARENT--> [?] Feeding or eating disorders\n Def: Feeding and Eating Disorders involve abnormal eating or feeding behaviours that are not explained by another health condition and are not developmentally appropriate or culturally sanctioned. Feeding ..."
] |
MG43.5
|
Excessive weight loss
|
[
{
"from_icd11": "MG43.5",
"icd10_code": "R634",
"icd10_title": "Abnormal weight loss"
},
{
"from_icd11": "MG43.6",
"icd10_code": "R635",
"icd10_title": "Abnormal weight gain"
},
{
"from_icd11": "5B80.0Z",
"icd10_code": "E669",
"icd10_title": "Obesity, unspecified"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2603",
"icd10_title": "Excessive weight gain in pregnancy, third trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2601",
"icd10_title": "Excessive weight gain in pregnancy, first trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O2602",
"icd10_title": "Excessive weight gain in pregnancy, second trimester"
},
{
"from_icd11": "JA65.2",
"icd10_code": "O260",
"icd10_title": "Excessive weight gain in pregnancy"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F5082",
"icd10_title": "Avoidant/restrictive food intake disorder"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F5089",
"icd10_title": "Other specified eating disorder"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F5081",
"icd10_title": "Binge eating disorder"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F9829",
"icd10_title": "Other feeding disorders of infancy and early childhood"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F9821",
"icd10_title": "Rumination disorder of infancy"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F508",
"icd10_title": "Other eating disorders"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F509",
"icd10_title": "Eating disorder, unspecified"
},
{
"from_icd11": "6B8Z",
"icd10_code": "F50",
"icd10_title": "Eating disorders"
}
] |
R634
|
Abnormal weight loss
|
Diagnosis and subtyping of cyclic CS are difficult, especially when periods of hypercortisolism are short and interspersed by periods of near-normal cortisol levels. Several pitfalls are possible, and we report here such a classical scenario in a patient with rapidly cycling hypercortisolism. The patient experienced, within a 2-year period, six cycles lasting usually not more than 4 weeks, with pronounced hypokalemia occurring in each phase . In such a situation, results of biochemical testing might be conflicting, and therapeutic decision making will often be prolonged. In our patient, identification of the ACTH source turned out to be extremely challenging. The BIPSS performed during a phase of normal cortisol secretion raised the suspicion of Cushing’s disease and lead to unsuccessful pituitary surgery, also because initial 68Ga-DOTATATE PET/CT imaging did not reveal an ectopic source. The second BIPSS during an ‘on phase’ of CS lead to the correct diagnosis, showing a typical ectopic pattern without any gradient . In a similar case, BIPSS performed during a trough phase was misleading, wrongly suggesting a peripheral ACTH source . The confirmation of high basal serum cortisol on the day of performing BIPSS could be helpful to avoid diagnostic failure and unsuitable testing . Other mistakes in the diagnostic workout of cyclic CS might be due to discrepancies of test results. For example, cortisol response to dexamethasone suppression test can be misleading, reflecting increased or decreased levels of cortisol secretion . The real prevalence of cyclic CS is hard to establish because of many difficulties related to the diagnosis. In a review of 65 patients with cyclic CS, pituitary tumors accounted for 54%, followed by ectopic (26%) and adrenocortical tumors (11%). Considering the low prevalence of patients with CS secondary to ectopic tumors, an ectopic source of ACTH hypersecretion seems to be more frequent in patients with biochemical episode of cycling . Neuroendocrine tumors of the thymus are the most frequently represented, followed by neuroendocrine bronchial tumors [ 4 , 19 – 26 ]. Other tumors reported as responsible of cyclic ectopic CS are pancreatic, renal and gastric NET [ 27 – 29 ], epithelial thymoma , phaeochromocytoma , carotid glomus tumor and ectopic pituitary adenoma . Surprisingly, although small cell lung carcinoma is frequent in patients with ectopic CS, biochemical episodes of cycling seem to be rare. Differentiating between ectopic and central ACTH source in cyclic CS is extremely challenging and the localization of the tumor can be very difficult, especially when it is not visible by imaging, as the fluctuations of cortisol levels may lead to several pitfalls. In around 13% of cases, the primary tumor remains unknown . The 68Ga-DOTATATE PET/CT is the first-line PET-imaging and seems to have more accuracy compared with 18F-DOPA-PET/CT . However, in our patient 18F-DOPA PET/CT was suggestive for a pancreatic lesion, which was not identified by 68Ga-DOTATATE PET/CT. Another case, in which 18F-DOPA-PET/CT but no 68Ga-DOTATATE PET/CT was able to identify the tumor lesion, has been reported . In our patient, the histopathology was unexpected, identifying the ‘pancreatic’ lesion as lymph node metastasis of an occult NET located in the retro-duodenal tissue adjacent to the pancreatic head. Because of the incomplete tumor resection, the patient underwent bilateral adrenalectomy, resolving the symptomatology. Bilateral adrenalectomy is a safe and effective treatment when the primary source of ACTH secretion is not surgically removable . An Italian multicentre study conducted in patients with ectopic CS showed a better survival rate in those who underwent adrenalectomy, in the first 2 years after surgery . Several factors may affect the prognosis in ectopic CS, such as severity of hypercortisolism with relative comorbidities, presence of hypokalaemia, type and grade of the NET and presence of metastases . Avoiding all the potential pitfalls is of primary importance in order to speed-up the diagnosis and prevent unnecessary treatments. In summary, we reported here the challenging case of a patient with a rapidly cycling Cushing’s syndrome secondary to ACTH-secreting neuroendocrine intestinal tumor of unknown primary, in whom a BIPSS performed during a trough phase was wrongly suggestive of central ACTH overproduction. This case highlights the potential pitfalls occurring in diagnosis, subtyping and localization of a tumor, which is cyclically the source of ACTH hypersecretion. It also demonstrates the importance of performing diagnostic tests only during the phases of active cortisol secretion, as soon as first symptoms appear. In addition, our case is peculiar because of the histopathology of the suspected pancreatic lesion, surprisingly conclusive for lymphonode metastasis of an occult NET located in the retro-duodenal tissue. To our knowledge, no similar cases have been reported in the literature. Fig. 2 Potassium levels over the time (weeks). Oral potassium supplementation was regularly started after diagnosis of hypokalemia
| 4.4375
| 0.587891
|
sec[2]/p[0]
|
en
| 0.999998
|
31640675
|
https://doi.org/10.1186/s12902-019-0433-9
|
[
"ectopic",
"acth",
"cortisol",
"source",
"tumor",
"cyclic",
"tumors",
"phase",
"bipss",
"patients"
] |
[
{
"code": "JA01.Z",
"title": "Ectopic pregnancy, unspecified"
},
{
"code": "LB17.1",
"title": "Ectopic anus"
},
{
"code": "LB30.7",
"title": "Ectopic or pelvic kidney"
},
{
"code": "DA07.Y",
"title": "Other specified disorders of tooth development or eruption"
},
{
"code": "BC9Y",
"title": "Other specified cardiac arrhythmia"
},
{
"code": "5A74.Y",
"title": "Other specified adrenocortical insufficiency"
},
{
"code": "5A70.1",
"title": "Ectopic ACTH syndrome"
},
{
"code": "5A70.Z",
"title": "Cushing syndrome, unspecified"
},
{
"code": "5A70.Y",
"title": "Other specified Cushing syndrome"
},
{
"code": "5A70.0",
"title": "Pituitary-dependent Cushing disease"
}
] |
=== ICD-11 CODES FOUND ===
[JA01.Z] Ectopic pregnancy, unspecified
Also known as: Ectopic pregnancy, unspecified | Ectopic pregnancy | extrauterine gestation or pregnancy | extrauterine pregnancy | EP - [ectopic pregnancy]
[LB17.1] Ectopic anus
Definition: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. This mild mislocation of the anus has been termed anterior ectopic anus. Anterior ectopic anus is different from imperforate anus with perineal fistula in that the anal opening is usually of normal size, and only mildly misplaced. Most of these children come to medical attention due to severe consti
Also known as: Ectopic anus | Misplaced anus | Anal ectopia
[LB30.7] Ectopic or pelvic kidney
Definition: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones
Also known as: Ectopic or pelvic kidney | Congenital displaced kidney | congenital misplaced kidney | congenital malposition of kidney | congenital prolapsed kidney
Includes: Congenital displaced kidney | Malrotation of kidney
[DA07.Y] Other specified disorders of tooth development or eruption
Also known as: Other specified disorders of tooth development or eruption | Enamel hypoplasia | enamel hypoplasia of single tooth | hypoplasia of enamel of teeth | localised enamel or dentine hypoplasia
[BC9Y] Other specified cardiac arrhythmia
Also known as: Other specified cardiac arrhythmia | Ectopic arrhythmia | ectopic cardiac arrhythmia | ectopic atrial pacemaker | ectopic rhythm NOS
[5A74.Y] Other specified adrenocortical insufficiency
Also known as: Other specified adrenocortical insufficiency | Congenital adrenocortical insufficiency | Congenital isolated ACTH deficiency | Familial adrenal hypoplasia | Familial hypoadrenocorticism
[5A70.1] Ectopic ACTH syndrome
Also known as: Ectopic ACTH syndrome | Cushing syndrome secondary to ectopic ACTH-secretion | Ectopic Cushing syndrome | hypercortisolism due to nonpituitary tumour | ectopic ACTH - [adrenocorticotropic hormone] secretion
[5A70.Z] Cushing syndrome, unspecified
Also known as: Cushing syndrome, unspecified | Cushing syndrome | Hyperadrenocorticism | Hypercortisolism | Cushing syndrome NOS
[5A70.Y] Other specified Cushing syndrome
Also known as: Other specified Cushing syndrome | ACTH-dependent Cushing syndrome | ACTH-independent Cushing syndrome | ACTH-independent Cushing syndrome due to bilateral adrenocortical hyperplasia | ACTH-independent macronodular adrenal hyperplasia
[5A70.0] Pituitary-dependent Cushing disease
Definition: Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical exper
Also known as: Pituitary-dependent Cushing disease | Overproduction of pituitary ACTH | Pituitary-dependent hyperadrenocorticism | Corticotroph pituitary adenoma | ACTH- [adrenocorticotropic hormone] secreting pituitary adenoma
=== GRAPH WALKS ===
--- Walk 1 ---
[JA01.Z] Ectopic pregnancy, unspecified
--PARENT--> [JA01] Ectopic pregnancy
Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....
--CHILD--> [JA01.2] Ovarian pregnancy
Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....
--- Walk 2 ---
[JA01.Z] Ectopic pregnancy, unspecified
--PARENT--> [JA01] Ectopic pregnancy
Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....
--CHILD--> [JA01.0] Abdominal pregnancy
Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....
--- Walk 3 ---
[LB17.1] Ectopic anus
Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...
--PARENT--> [LB17] Structural developmental anomalies of anal canal
--CHILD--> [LB17.1] Ectopic anus
Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...
--- Walk 4 ---
[LB17.1] Ectopic anus
Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...
--PARENT--> [LB17] Structural developmental anomalies of anal canal
--CHILD--> [LB17.0] Anorectal malformations
Def: Anorectal malformations (ARMs) are birth defects (due to alterations in embryo development of hindgut or proctodeum) where the anus and rectum (the lower end of the digestive tract) do not develop pro...
--- Walk 5 ---
[LB30.7] Ectopic or pelvic kidney
Def: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones...
--PARENT--> [LB30] Structural developmental anomalies of kidneys
Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....
--CHILD--> [LB30.2] Congenital single renal cyst
Def: A single cyst in a kidney, noted in utero or from birth. No other structural abnormality of the kidney or urinary tract noted....
--- Walk 6 ---
[LB30.7] Ectopic or pelvic kidney
Def: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones...
--PARENT--> [LB30] Structural developmental anomalies of kidneys
Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....
--CHILD--> [LB30.0] Renal agenesis or other reduction defects of kidney
Def: A series of conditions resulting in reduced kidney function including a congenital absence of both kidneys...
|
[
"[JA01.Z] Ectopic pregnancy, unspecified\n --PARENT--> [JA01] Ectopic pregnancy\n Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....\n --CHILD--> [JA01.2] Ovarian pregnancy\n Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....",
"[JA01.Z] Ectopic pregnancy, unspecified\n --PARENT--> [JA01] Ectopic pregnancy\n Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....\n --CHILD--> [JA01.0] Abdominal pregnancy\n Def: A condition characterised by implantation of the embryo within the peritoneal cavity during pregnancy....",
"[LB17.1] Ectopic anus\n Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...\n --PARENT--> [LB17] Structural developmental anomalies of anal canal\n --CHILD--> [LB17.1] Ectopic anus\n Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...",
"[LB17.1] Ectopic anus\n Def: While children with imperforate or obviously mislocated anus are identified in the newborn period, some children with a very mild abnormality may escape identification until after the newborn period. ...\n --PARENT--> [LB17] Structural developmental anomalies of anal canal\n --CHILD--> [LB17.0] Anorectal malformations\n Def: Anorectal malformations (ARMs) are birth defects (due to alterations in embryo development of hindgut or proctodeum) where the anus and rectum (the lower end of the digestive tract) do not develop pro...",
"[LB30.7] Ectopic or pelvic kidney\n Def: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones...\n --PARENT--> [LB30] Structural developmental anomalies of kidneys\n Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....\n --CHILD--> [LB30.2] Congenital single renal cyst\n Def: A single cyst in a kidney, noted in utero or from birth. No other structural abnormality of the kidney or urinary tract noted....",
"[LB30.7] Ectopic or pelvic kidney\n Def: A birth defect characterised by an abnormally positioned kidney; may be asymptomatic or result in urine blockage, infection or kidney stones...\n --PARENT--> [LB30] Structural developmental anomalies of kidneys\n Def: Any condition caused by failure of the kidneys to correctly develop during the antenatal period....\n --CHILD--> [LB30.0] Renal agenesis or other reduction defects of kidney\n Def: A series of conditions resulting in reduced kidney function including a congenital absence of both kidneys..."
] |
JA01.Z
|
Ectopic pregnancy, unspecified
|
[
{
"from_icd11": "JA01.Z",
"icd10_code": "O0081",
"icd10_title": "Other ectopic pregnancy with intrauterine pregnancy"
},
{
"from_icd11": "JA01.Z",
"icd10_code": "O0080",
"icd10_title": "Other ectopic pregnancy without intrauterine pregnancy"
},
{
"from_icd11": "JA01.Z",
"icd10_code": "O0090",
"icd10_title": "Unspecified ectopic pregnancy without intrauterine pregnancy"
},
{
"from_icd11": "JA01.Z",
"icd10_code": "O008",
"icd10_title": "Other ectopic pregnancy"
},
{
"from_icd11": "JA01.Z",
"icd10_code": "O009",
"icd10_title": "Ectopic pregnancy, unspecified"
},
{
"from_icd11": "JA01.Z",
"icd10_code": "O00",
"icd10_title": "Ectopic pregnancy"
},
{
"from_icd11": "LB17.1",
"icd10_code": "Q435",
"icd10_title": "Ectopic anus"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q632",
"icd10_title": "Ectopic kidney"
},
{
"from_icd11": "LB30.7",
"icd10_code": "Q63",
"icd10_title": "Other congenital malformations of kidney"
},
{
"from_icd11": "5A70.1",
"icd10_code": "E243",
"icd10_title": "Ectopic ACTH syndrome"
},
{
"from_icd11": "5A70.Z",
"icd10_code": "E242",
"icd10_title": "Drug-induced Cushing's syndrome"
},
{
"from_icd11": "5A70.Z",
"icd10_code": "E249",
"icd10_title": "Cushing's syndrome, unspecified"
},
{
"from_icd11": "5A70.Z",
"icd10_code": "E248",
"icd10_title": "Other Cushing's syndrome"
},
{
"from_icd11": "5A70.Z",
"icd10_code": "E24",
"icd10_title": "Cushing's syndrome"
},
{
"from_icd11": "5A70.0",
"icd10_code": "E240",
"icd10_title": "Pituitary-dependent Cushing's disease"
}
] |
O0081
|
Other ectopic pregnancy with intrauterine pregnancy
|
MALT lymphoma is considered an extranodal variant of marginal zone B-cell lymphoma and is a distinct entity of NHL . It is more frequent in women older than 60 years of age, but some cases have been reported in children, as shown by the literature data summarised in Table 1 . This subtype of B-cell lymphoma has a better prognosis than its nodal counterparts, with a rather indolent evolution and a tendency to remain localised, as approximately only a quarter of the cases tend to disseminate to multiple sites. The most common site of development is the stomach, and the majority of gastric MALT lymphomas are associated with Helicobacter pylori infection . Salivary and thyroid MALT lymphomas are associated with autoimmune disorders, such as Sjögren syndrome and Hashimoto disease, respectively . Their occurrence on the mucosa of the oral cavity as primary tumours is extremely rare , and they present mainly as mass swellings on the tongue or as nodular forms in the lip or buccal mucosa (Table 1 ). The clinical manifestation may lead to the histological diagnosis on a biopsy sample or a resected specimen. In our reported case, the patient did not present any clinical manifestations or symptomatology. The nodule under the mucosal lesion was discovered fortuitously during a careful clinical examination of a 73-year-old woman with a history of IgM kappa MGUS for more than 13 years with no known or identified lesions and no specific clinical manifestation. No superficial adenomegaly or splenomegaly was highlighted on physical examination, but electrophoresis of plasma proteins showed an IgM level of 5.4 g/L at the time of MGUS discovery, which increased gradually to 13.16 g/L at the time of detection of the right cheek mucosal nodule. The LDH level was normal, and beta-2 microglobulin level was 2.45 mg/L. Blood tests for autoimmunity were performed (anti-Sm, anti-RNP, anti-SS-A, anti-SS-B, anti-Sc70, anti-JO-1) and found to be normal, as were thyrostimulin (TSH) and thyroxin (T4) levels. Renal and liver function tests, as well as blood cell count, were normal. No proteinuria was evidenced. Serology for C hepatitis (HCV) was negative, and endoscopic examination of the gastrointestinal tract showed no particularity. Overall, our patient presented no specific risk factors for the development of MALT lymphoma, more particularly, of the oral mucosa, which is a rare and atypical extra nodal localisation of this type of lymphoma. Table 1 Clinical and pathological characteristics of reported cases of isolated oral MALT lymphoma without autoimmune or infection diseases Case References Country Age (years) Sex Site CD5 Light chain Clinical manifestation Involvement MSG Management Recurrence Κ λ 1 Iftikhar et al. Pakistan 61 M BoT + NK NK Dysphagia − CT − 2 Song et al. Korea 29 F BoT NK NK NK Mass involving T lymphoma history − RT − 3 Gotri et al. Italy 80 F BoT + + − Dysphagia − SR − 4 Ferry et al. USA 62 F BoT + − + Mass − NK Spread 5 Kojima et al. Japan 51 M SP − + − ND + SR − 6 60 M BM − − − ND − SR + RT − 7 64 F SP − + − ND + SR + 8 78 F Ging − − − ND − RT − 9 83 M Ging − − − ND − CT + 10 Sakabe et al. Japan 61 F BoT + NK NK Mass + SR − 11 Ayers et al. USA 64 F HP NK NK NK Mass + NK NK 12 Bombeccari et al. Italy 11 M LL − + NK Swelling − SR − 13 Kojima et al. Japan 78 F BM − − + Swelling − NK NK 14 Kolokotronis et al. Greece 68 M Ts NK NK NK NK NK SR + CT + 15 73 F HP NK NK NK NK NK SR + 16 48 F Ts NK NK NK NK NK SR + 17 Crandley et al. USA 9 F LL NK − + Swelling + SR − 18 Frazier et al. USA 50 M UL − + − Swelling + SR − 19 Abe et al. Japan 64 F HP + + + Swelling − SR + RT + CT NK 20 Berrebi et al. France 10 M LL NK NK NK Mass + SR − 21 Eder UK 52 M FoM NK NK NK Mass NK SR − 22 Gabali et al. USA 11 M LL − − − Swelling + SR NK 23 Ruy et al. Korea 7 F LL − + − Mass CT − 24 Tanaka et al. Japan 66 F BM + + + Swelling − SR − 25 Gerami USA 57 F LL, To then UL − NK NK Swelling − CT + 26 Honda et al. Japan 71 F FOM NK + NK Swelling NK RT − 27 Kaplan et al. Israel 59 F LL − NK NK NK + CT + anti-CD20 − 87 F LL − NK NK Mass + SR − 82 F UL − NK NK Mass + SR − 82 F LL − NK NK Mass + SR − 66 F LL − NK NK Mass + SR − 71 F UL and later LL − NK NK Mass − SR − 33 Kawasaki et al. Japan 27 M UL and LL NK NK NK Mass + SR − 34 Song et al. Korea 29 F BoT − NK NK Mass RT − 35 Mo et al. USA 12 M LL − + − Mass + CT − 36 Zehani et al. Tunis 28 F Cheek − + − Swelling − NK NK 37 Zambrano et al. USA 14 M UL − + + Mass NK NK NK 38 Urano et al. Japan 62 F Cheek NK − + Swelling RT + anti-CD20 − 39 Ma et al. China 59 F Ts − − − Swelling − SR + RT − 40 Manveen et al. India 40 M HP + NK NK Swelling − SR − 41 Bianco et al. Italy 82 M UL − NK NK Swelling − CT + RT − 42 Tauber et al. Germany 71 F HP NK NK NK Mass NK SR − MSG minor salivary gland, BOT base of the tongue, SP soft palate, BM buccal mucosa, Ging gingiva, HP hard palate, LL lower lip, Ts tonsil, UL upper lip, FoM floor of the mouth, To tongue, SR surgical resection, CT chemotherapy, RT radiotherapy, NK not known, –/+ absence/presence of marker expression (CD5, Κ, λ), absence/presence of salivary gland structure, no recurrence/recurrence
| 4.257813
| 0.495361
|
sec[2]/p[2]
|
en
| 0.999995
|
34814897
|
https://doi.org/10.1186/s12903-021-01960-y
|
[
"swelling",
"anti",
"japan",
"lymphoma",
"malt",
"mucosa",
"cell",
"cases",
"salivary",
"oral"
] |
[
{
"code": "FA36.Z",
"title": "Effusion of joint, unspecified"
},
{
"code": "MA01.Z",
"title": "Enlarged lymph nodes, unspecified"
},
{
"code": "MD82",
"title": "Intra-abdominal or pelvic swelling, mass or lump"
},
{
"code": "ME61",
"title": "Subcutaneous swelling, mass or lump of uncertain or unspecified nature"
},
{
"code": "GB90.Y",
"title": "Other specified disorders of kidney or ureter"
},
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MB23.1",
"title": "Antisocial behaviour"
},
{
"code": "3B4Z",
"title": "Coagulation defects, unspecified"
},
{
"code": "4A45.Z",
"title": "Antiphospholipid syndrome, unspecified"
},
{
"code": "4A43.Y",
"title": "Other specified overlap non-organ specific systemic autoimmune disease"
}
] |
=== ICD-11 CODES FOUND ===
[FA36.Z] Effusion of joint, unspecified
Also known as: Effusion of joint, unspecified | Effusion of joint | effusion into joint | effusion of joint, site unspecified | hydrarthrosis
[MA01.Z] Enlarged lymph nodes, unspecified
Also known as: Enlarged lymph nodes, unspecified | Enlarged lymph nodes | swollen glands | Lymphadenopathy | adenopathy
[MD82] Intra-abdominal or pelvic swelling, mass or lump
Definition: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation.
Also known as: Intra-abdominal or pelvic swelling, mass or lump | Abdominal mass without further specification | mass in abdomen | intra-abdominal lump | intra-abdominal mass
Excludes: Abdominal distension | Ascites
[ME61] Subcutaneous swelling, mass or lump of uncertain or unspecified nature
Definition: One or more localised subcutaneous soft tissue masses of undetermined or unspecified nature
Also known as: Subcutaneous swelling, mass or lump of uncertain or unspecified nature | localised swelling, mass or lump of skin and subcutaneous tissue | localised subcutaneous nodules | subcutaneous nodules | superficial subcutaneous nodules
Excludes: localized adiposity | mass and lump: breast | enlarged lymph nodes
[GB90.Y] Other specified disorders of kidney or ureter
Also known as: Other specified disorders of kidney or ureter | Other secondary disorders of kidney or ureter | Other disorders of kidney and ureter NEC | Inflammatory diseases of the renal pelvis or the ureter without tubulo-interstitial nephritis | Infectious diseases of the renal pelvis or the ureter without tubulo-interstitial nephritis
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MB23.1] Antisocial behaviour
Definition: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated.
Also known as: Antisocial behaviour | Child or adolescent antisocial behaviour
[3B4Z] Coagulation defects, unspecified
Also known as: Coagulation defects, unspecified | blood clotting disturbance | blood clotting defect | blood clotting factor deficiency | clotting abnormality
[4A45.Z] Antiphospholipid syndrome, unspecified
Also known as: Antiphospholipid syndrome, unspecified | Antiphospholipid syndrome | Hughes syndrome | Anticardiolipin syndrome
[4A43.Y] Other specified overlap non-organ specific systemic autoimmune disease
Also known as: Other specified overlap non-organ specific systemic autoimmune disease | Antisynthetase syndrome | Reynolds syndrome | Syndromic multisystem autoimmune disease due to ITCH deficiency | Eosinophilia myalgia syndrome
=== GRAPH WALKS ===
--- Walk 1 ---
[FA36.Z] Effusion of joint, unspecified
--PARENT--> [FA36] Effusion of joint
Def: Increased intra-articular fluid secondary to trauma and/or other acquired conditions not detailed in other codes....
--EXCLUDES--> [?] Tertiary yaws
Def: Tertiary yaws develops in <10% of untreated infected individuals after and interval of 5 years or more. The late stage skin lesions are characterised by gummatous nodules with necrotic tissue destruct...
--- Walk 2 ---
[FA36.Z] Effusion of joint, unspecified
--PARENT--> [FA36] Effusion of joint
Def: Increased intra-articular fluid secondary to trauma and/or other acquired conditions not detailed in other codes....
--CHILD--> [FA36.Z] Effusion of joint, unspecified
--- Walk 3 ---
[MA01.Z] Enlarged lymph nodes, unspecified
--PARENT--> [MA01] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--CHILD--> [MA01.0] Localised lymph node enlargement
--- Walk 4 ---
[MA01.Z] Enlarged lymph nodes, unspecified
--PARENT--> [MA01] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--EXCLUDES--> [?] Chronic lymphadenitis
--- Walk 5 ---
[MD82] Intra-abdominal or pelvic swelling, mass or lump
Def: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation....
--EXCLUDES--> [?] Ascites
Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...
--CHILD--> [?] Fluid in peritoneal cavity
--- Walk 6 ---
[MD82] Intra-abdominal or pelvic swelling, mass or lump
Def: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation....
--EXCLUDES--> [?] Abdominal distension
Def: This is a condition in which the abdomen feels full and tight because of swelling of the abdomen, usually due to an increased amount of intestinal gas, but occurs sometimes when fluid, substances or m...
--PARENT--> [?] Symptoms related to the lower gastrointestinal tract or abdomen
|
[
"[FA36.Z] Effusion of joint, unspecified\n --PARENT--> [FA36] Effusion of joint\n Def: Increased intra-articular fluid secondary to trauma and/or other acquired conditions not detailed in other codes....\n --EXCLUDES--> [?] Tertiary yaws\n Def: Tertiary yaws develops in <10% of untreated infected individuals after and interval of 5 years or more. The late stage skin lesions are characterised by gummatous nodules with necrotic tissue destruct...",
"[FA36.Z] Effusion of joint, unspecified\n --PARENT--> [FA36] Effusion of joint\n Def: Increased intra-articular fluid secondary to trauma and/or other acquired conditions not detailed in other codes....\n --CHILD--> [FA36.Z] Effusion of joint, unspecified",
"[MA01.Z] Enlarged lymph nodes, unspecified\n --PARENT--> [MA01] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --CHILD--> [MA01.0] Localised lymph node enlargement",
"[MA01.Z] Enlarged lymph nodes, unspecified\n --PARENT--> [MA01] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....\n --EXCLUDES--> [?] Chronic lymphadenitis",
"[MD82] Intra-abdominal or pelvic swelling, mass or lump\n Def: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation....\n --EXCLUDES--> [?] Ascites\n Def: Accumulation or retention of free fluid in the abdominal peritoneal cavity between the tissues lining the abdomen and abdominal organs. The fluid may be serous, haemorrhagic, or the result of inflamma...\n --CHILD--> [?] Fluid in peritoneal cavity",
"[MD82] Intra-abdominal or pelvic swelling, mass or lump\n Def: This refers to the presence of abdominal or pelvic wall swelling, mass or tumour in the abdominal and pelvic regions. These mass or tumours can be recognised by visual examination and/or palpation....\n --EXCLUDES--> [?] Abdominal distension\n Def: This is a condition in which the abdomen feels full and tight because of swelling of the abdomen, usually due to an increased amount of intestinal gas, but occurs sometimes when fluid, substances or m...\n --PARENT--> [?] Symptoms related to the lower gastrointestinal tract or abdomen"
] |
FA36.Z
|
Effusion of joint, unspecified
|
[
{
"from_icd11": "FA36.Z",
"icd10_code": "M25471",
"icd10_title": "Effusion, right ankle"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25461",
"icd10_title": "Effusion, right knee"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25462",
"icd10_title": "Effusion, left knee"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25431",
"icd10_title": "Effusion, right wrist"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25472",
"icd10_title": "Effusion, left ankle"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25451",
"icd10_title": "Effusion, right hip"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M2548",
"icd10_title": "Effusion, other site"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25411",
"icd10_title": "Effusion, right shoulder"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25441",
"icd10_title": "Effusion, right hand"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25452",
"icd10_title": "Effusion, left hip"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25421",
"icd10_title": "Effusion, right elbow"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25432",
"icd10_title": "Effusion, left wrist"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25473",
"icd10_title": "Effusion, unspecified ankle"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25412",
"icd10_title": "Effusion, left shoulder"
},
{
"from_icd11": "FA36.Z",
"icd10_code": "M25422",
"icd10_title": "Effusion, left elbow"
}
] |
M25471
|
Effusion, right ankle
|
A 64-year-old male presented to the ED three days after having dental implants placed in the maxilla for a fixed hybrid denture prosthesis. The patient had mentioned to the Oral and Maxillofacial Surgeon that he was taking clopidogrel, but the physician decided discontinuation was unnecessary. In smaller procedures such as simple extractions, the continuation of OACs may be advisable. In this case, however, discontinuation should have been considered due to the more invasive nature of this particular procedure. The patient received a right-side dental implant-supported fixed denture, replacing all maxillary teeth. This requires multiple dental implants in the right and left maxilla for retention of the prosthesis. Upon arrival to the ED, the patient appeared disheveled, in a moderate amount of distress, and was wearing a blood-soaked t-shirt from an obvious oral bleed. The patient remained alert and oriented for the entirety of the visit. The patient stated that the bleed began approximately six hours before arrival, with the implant procedure being three days prior. No bleeding was noticed or appreciated until the initial onset six hours beforehand. On examination, the patient was bleeding from somewhere beneath his recently placed right-sided maxillary dental implants, but the exact source of the bleed could not be seen. His maxillary denture was fixed to the recently placed implants, and could not be removed to observe the bleeding site as they are meant to be permanent. The bleed was slow but constant, and suction was required every 10-15 minutes to maintain the patient’s airway efficiently due to pooling blood in the back of the oropharynx. International normalized ratio (INR) values, explained later, are used to measure blood coagulability. The patient had an INR of 1.3 on ED bloodwork which is considered mildly elevated. Although the discontinuation of OAC prior to surgery can be controversial depending on the procedure, both systematic review and retrospective analysis suggest that the absolute risk is low and there is no need to discontinue or alter the dose of the antithrombotic treatment for implant placement surgery safely . It is still highly recommended to thoroughly screen patients for the medications they are on, but in this particular case, the discontinuation of clopidogrel may not have been advisable. Given that the location of the bleed was beneath the fixed denture and unreachable by the Emergency Physician, as opposed to an easily accessible tooth extraction site, for example, alternative measures to compression with topical clotting agents were needed when multiple local compression attempts had failed. The following sequence was used, in order, to try and resolve the bleeding following the failure of compression and topical clotting agent. Tranexamic acid (TXA) via soaked gauze was used. TXA is also a commonly used topical agent in cases of epistaxis, so utilizing the agent in other ENT situations would likely prove to be effective. In the case of this patient, however, the TXA-soaked gauze did not effectively control the bleeding. This is most likely once again attributed to the inability to reach the bleeding site beneath the prosthetic implant. The next attempt was aimed at using a mouth rinse of a brand-name nasal decongestant known as Afrin (oxymetazoline HCl). Traditionally, the medication is used for vasoconstriction of nasal blood vessels which will decrease mucous secretions. In this case, however, the vasoconstrictive properties would help sequester bleeding and potentially have a better chance of reaching the bleed being a liquid solution. Unfortunately, this was not effective in controlling the bleed, and additional measures were needed. By this point, Oral Surgery was consulted on the case by the Emergency Physician and the surgeon came in to evaluate the patient. Upon arrival, the surgeon requested local lidocaine 1% with epinephrine. While lidocaine is traditionally used for pain management during local procedures, the true purpose of this solution was for the epinephrine it contained. Epinephrine is a potent vasoconstrictor, and it happens to be injectable subcutaneously when necessary. The decision to inject areas of branching vessels surrounding the prosthetic was made to more effectively control the bleed further away from the actual site that remained invisible. The surgeon injected 4 mL of lidocaine with epinephrine (1:100,000) into the right hard and soft palate, as well as the buccal gingiva to gain full coverage around the prosthetic. After just a few minutes, the bleeding subsided. If the bleeding was unable to be controlled, the fixed dental prosthesis would have had to be removed and the site of the wound cauterized. This removal process is a technical dental procedure requiring special equipment and would take additional time to perform. The patient required intravenous fluids for volume replacement after losing approximately 1 L of blood while in the ED over the course of 2.5 hours. The patient was able to be discharged with a follow-up with his primary care provider in three to five days.
| 4.070313
| 0.958984
|
sec[1]/p[0]
|
en
| 0.999998
|
PMC9588282
|
https://doi.org/10.7759/cureus.29495
|
[
"this",
"bleeding",
"bleed",
"dental",
"used",
"fixed",
"that",
"blood",
"site",
"implants"
] |
[
{
"code": "4A01.03",
"title": "Transient hypogammaglobulinaemia of infancy"
},
{
"code": "MG27",
"title": "Haemorrhage, not elsewhere classified"
},
{
"code": "GA21.0",
"title": "Postcoital or contact bleeding"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "DB98.A",
"title": "Hepatic haemorrhage"
},
{
"code": "GA20.3",
"title": "Abnormal regularity of uterine bleeding"
},
{
"code": "DA07.3",
"title": "Disturbances in tooth formation"
},
{
"code": "DA09.61",
"title": "Periapical abscess with sinus"
},
{
"code": "QA00.8",
"title": "Dental examination"
},
{
"code": "DA08.0",
"title": "Dental caries"
}
] |
=== ICD-11 CODES FOUND ===
[4A01.03] Transient hypogammaglobulinaemia of infancy
Also known as: Transient hypogammaglobulinaemia of infancy | immunoglobulin maturational delay | THI - [transient hypogammaglobulinaemia of infancy]
[MG27] Haemorrhage, not elsewhere classified
Definition: Bleeding or escape of blood from a vessel.
Also known as: Haemorrhage, not elsewhere classified | arterial haemorrhage | bleeding | extravasation of blood | Haemorrhage NOS
Excludes: Obstetric haemorrhage | Haemorrhage or haematoma complicating a procedure, not elsewhere classified | Fetal blood loss
[GA21.0] Postcoital or contact bleeding
Definition: A condition of the genital system, caused by infection, cervical ectropion, cervical or endometrial polyps, cancer, or trauma to the cervix or vagina. This condition is characterised by non-menstrual bleeding after sexual intercourse. Confirmation is by transvaginal imaging to identify any structural abnormalities.
Also known as: Postcoital or contact bleeding | Postcoital bleeding | bleeding after intercourse | PCB - [postcoital bleeding] | postcoital haemorrhage
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[DB98.A] Hepatic haemorrhage
Definition: Traumatic or nontraumatic spontaneous bleeding in the liver. The most common cause of the latter is the rupture of liver tumours.
Also known as: Hepatic haemorrhage | haemorrhage of liver | hepatic bleeding | hepatorrhagia | liver haemorrhage
Excludes: Hepatic haemorrhage due to hepatocellular carcinoma
[GA20.3] Abnormal regularity of uterine bleeding
Definition: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days.
Also known as: Abnormal regularity of uterine bleeding | Irregular menstrual bleeding | irregular cycle menstruation | irregular menses | irregular menstrual cycle
[DA07.3] Disturbances in tooth formation
Definition: A group of conditions characterised by disturbances in tooth formation.
Also known as: Disturbances in tooth formation | disturbance of tooth formation | Dental dysplasia | disorder of tooth formation | Florid cemento-osseous dysplasia
Includes: Dental dysplasia | Florid cemento-osseous dysplasia | Regional odontodysplasia
Excludes: Hutchinson teeth and mulberry molars in congenital syphilis | mottled teeth
[DA09.61] Periapical abscess with sinus
Also known as: Periapical abscess with sinus | Dental abscess with sinus | Dentoalveolar abscess with sinus | Dental sinus | periapical abscess fistula
Includes: Dental abscess with sinus | Dentoalveolar abscess with sinus | Dental sinus
[QA00.8] Dental examination
Also known as: Dental examination | examination of teeth
[DA08.0] Dental caries
Definition: A condition characterised by localised destruction of calcified tissue, initiated on the tooth surface by decalcification of the enamel, followed by the enzymatic lysis of organic structures, resulting in cavity formation.
Also known as: Dental caries | Dental decay | carious teeth | dental cavity | saprodontia
Includes: Dental decay
=== GRAPH WALKS ===
--- Walk 1 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--PARENT--> [4A01] Primary immunodeficiencies due to disorders of adaptive immunity
--- Walk 2 ---
[4A01.03] Transient hypogammaglobulinaemia of infancy
--PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects
Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...
--CHILD--> [4A01.00] Hereditary agammaglobulinaemia with profoundly reduced or absent B cells
Def: This refers to a hereditary type of primary immune deficiency disease characterised by a reduction in all types of gamma globulins, and rare X-linked genetic disorder that affects the body's ability t...
--- Walk 3 ---
[MG27] Haemorrhage, not elsewhere classified
Def: Bleeding or escape of blood from a vessel....
--EXCLUDES--> [?] Obstetric haemorrhage
--CHILD--> [?] Antepartum haemorrhage
--- Walk 4 ---
[MG27] Haemorrhage, not elsewhere classified
Def: Bleeding or escape of blood from a vessel....
--EXCLUDES--> [?] Haemorrhage or haematoma complicating a procedure, not elsewhere classified
--CHILD--> [?] Haematoma of surgical wound of skin
Def: Collection of blood within skin and soft tissues following surgical wound of skin usually resulting from defective haemostasis...
--- Walk 5 ---
[GA21.0] Postcoital or contact bleeding
Def: A condition of the genital system, caused by infection, cervical ectropion, cervical or endometrial polyps, cancer, or trauma to the cervix or vagina. This condition is characterised by non-menstrual ...
--PARENT--> [GA21] Nonmenstrual bleeding disorders
--RELATED_TO--> [?] Postprocedural nonmenstrual uterine bleeding
Def: Uterine bleeding occurring after procedure (i.e. uterine surgery, induced abortion, …)...
--- Walk 6 ---
[GA21.0] Postcoital or contact bleeding
Def: A condition of the genital system, caused by infection, cervical ectropion, cervical or endometrial polyps, cancer, or trauma to the cervix or vagina. This condition is characterised by non-menstrual ...
--PARENT--> [GA21] Nonmenstrual bleeding disorders
--CHILD--> [GA21.Y] Other specified nonmenstrual bleeding disorders
|
[
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --PARENT--> [4A01] Primary immunodeficiencies due to disorders of adaptive immunity",
"[4A01.03] Transient hypogammaglobulinaemia of infancy\n --PARENT--> [4A01.0] Immunodeficiencies with predominantly antibody defects\n Def: A disorder characterised by an inability to mount a normal immune response due to antibody (i.e. immunoglobulin) defects...\n --CHILD--> [4A01.00] Hereditary agammaglobulinaemia with profoundly reduced or absent B cells\n Def: This refers to a hereditary type of primary immune deficiency disease characterised by a reduction in all types of gamma globulins, and rare X-linked genetic disorder that affects the body's ability t...",
"[MG27] Haemorrhage, not elsewhere classified\n Def: Bleeding or escape of blood from a vessel....\n --EXCLUDES--> [?] Obstetric haemorrhage\n --CHILD--> [?] Antepartum haemorrhage",
"[MG27] Haemorrhage, not elsewhere classified\n Def: Bleeding or escape of blood from a vessel....\n --EXCLUDES--> [?] Haemorrhage or haematoma complicating a procedure, not elsewhere classified\n --CHILD--> [?] Haematoma of surgical wound of skin\n Def: Collection of blood within skin and soft tissues following surgical wound of skin usually resulting from defective haemostasis...",
"[GA21.0] Postcoital or contact bleeding\n Def: A condition of the genital system, caused by infection, cervical ectropion, cervical or endometrial polyps, cancer, or trauma to the cervix or vagina. This condition is characterised by non-menstrual ...\n --PARENT--> [GA21] Nonmenstrual bleeding disorders\n --RELATED_TO--> [?] Postprocedural nonmenstrual uterine bleeding\n Def: Uterine bleeding occurring after procedure (i.e. uterine surgery, induced abortion, …)...",
"[GA21.0] Postcoital or contact bleeding\n Def: A condition of the genital system, caused by infection, cervical ectropion, cervical or endometrial polyps, cancer, or trauma to the cervix or vagina. This condition is characterised by non-menstrual ...\n --PARENT--> [GA21] Nonmenstrual bleeding disorders\n --CHILD--> [GA21.Y] Other specified nonmenstrual bleeding disorders"
] |
4A01.03
|
Transient hypogammaglobulinaemia of infancy
|
[
{
"from_icd11": "4A01.03",
"icd10_code": "D807",
"icd10_title": "Transient hypogammaglobulinemia of infancy"
},
{
"from_icd11": "MG27",
"icd10_code": "R58",
"icd10_title": "Hemorrhage, not elsewhere classified"
},
{
"from_icd11": "GA21.0",
"icd10_code": "N930",
"icd10_title": "Postcoital and contact bleeding"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R3129",
"icd10_title": "Other microscopic hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R3121",
"icd10_title": "Asymptomatic microscopic hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R311",
"icd10_title": "Benign essential microscopic hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R319",
"icd10_title": "Hematuria, unspecified"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R31",
"icd10_title": "Hematuria"
},
{
"from_icd11": "DB98.A",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB98.A",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB98.A",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N926",
"icd10_title": "Irregular menstruation, unspecified"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N925",
"icd10_title": "Other specified irregular menstruation"
}
] |
D807
|
Transient hypogammaglobulinemia of infancy
|
He was then hospitalized at the age of 32 for severe diarrhea and progressive epigastric pain. He had rectal bleeding and his disease activity was severe according to the Truelove and Witts’ severity index. On physical examination at the time of hospitalization, body temperature was 39.8°C and the abdomen was diffusely tender without muscular guarding or rigidity. Laboratory data, including complete blood count and coagulation profile, were within normal range aside from microcytic and hypochromic anemia with a hemoglobin level of 11.5 g/dL. Serum C-reactive protein (CRP) level was elevated at 23.9 mg/L. Serum tumor markers were within the normal range. Blood, stool, and urine cultures were negative. Cytomegalovirus (CMV) antigenemia test was negative, and antinuclear antibody and serum complement were both in the normal range. Contrast-enhanced computed tomography (CT) showed marked colonic wall thickening extending from the transverse colon to the rectum, but there was no abnormality in the mesenteric vessels and no abdominal free air . Colonoscopy revealed highly edematous mucosa, complete obliteration of the vascular pattern, and multiple deep ulcerations extending from the transverse colon to the rectum . Histopathology of biopsies obtained during colonoscopy showed findings consistent with possible UC. Basal plasmacytosis and eosinophil infiltration were unremarkable and there was no typical “owl eye” inclusion indicating CMV infection . Based on clinical findings, Buerger’s disease, Behçet’s disease, rheumatoid arthritis, and systemic lupus erythematosus were excluded. A diagnosis of severe UC was made and intravenous steroids and antibiotic therapy were started. Since the clinical symptoms and laboratory blood data were not improved by the systemic steroid therapy, the dose of steroids was decreased gradually on the 10th hospital day, while oral administration of tacrolimus was started and maintained at a high trough level. However, his clinical symptoms were completely unresponsive to tacrolimus therapy and surgical colectomy was recommended, but he strongly refused surgery, and consent was not obtained. We performed four sessions of granulocyte and monocyte adsorption apheresis as an additional therapy. On the 35th hospital day, his abdominal pain had worsened with rebound tenderness and ultimately led to a state of shock. CT revealed dilated loops of colon and abdominal free air . Following a diagnosis of perforation peritonitis complicated with toxic megacolon, subtotal colectomy and ileostomy were performed . Histopathology of the surgically resected colon showed only minor changes in the mucosal histological structure; however, many veins present from the submucosal layer to the subserosal layer demonstrated prominent myointimal hyperplasia with narrowed lumens in contrast to arteries that were essentially normal . Vasculitis of the small mesenteric veins and their intramural tributaries with thrombosis was also observed . These findings confirmed the diagnosis of MIVOD. Despite the occurrence of various postoperative complications, including acute respiratory distress syndrome (ARDS), CMV infection (Given the positive finding of CMV-C7HRP in his blood during management in the postoperative ICU, administration of ganciclovir was performed and we confirmed a negative result for CMV-C7HRP 14 days after administration of ganciclovir.), rectal hemorrhage, and renal failure, the patient gradually improved with multidisciplinary treatment and was discharged after 6 months of hospitalization. He is in remission with oral administration of 5ASA after discharge. The clinical course of this patient is shown in Fig. 5 . Fig. 2 a Contrast-enhanced computed tomography showed long segment marked colonic wall thickening extending from the transverse colon to the distal rectum on the first day of hospitalization. b Computed tomography revealed abdominal free air and dilated loops of colon on the 35th hospital day Fig. 3 a Colonoscopy showed confluent deep ulceration and loss of mucosal architecture. b Pathological findings were consistent with possible ulcerative colitis. Hematoxylin-eosin staining Fig. 4 a Gross feature of surgical excision specimen. Deep longitudinal ulcers with fusion tendency were scattered in the large intestine. The yellow line indicates the site where the following tissue examination was performed. b Histopathology showed only minor changes in the mucosalstructure, but many veins in submucosal layer demonstrated prominent myointimal hyperplasia with narrowed lumens. Hematoxylin-eosin staining. c Arteries of submucosal layer were essentially normal (*). Venous thrombi of varying age were identified (arrow heads). d Small mesenteric vein and its intramural tributaries showed partly organized thrombi. Hematoxylin-eosin staining Fig. 5 The clinical course of this patient. CT: Computed tomography; CRP: C-reactive protein; CMV: Cytomegalovirus; GMA: Granulocyte Monocyte Apheresis; LVFX: Levofloxacin; MIVOD: Mesenteric inflammatory veno-occlusive disease; PSL: Prednisolone; UC: Ulcerative colitis; 5-ASA: 5-aminosalicylic acid
| 4.03125
| 0.976563
|
sec[1]/p[1]
|
en
| 0.999996
|
29325532
|
https://doi.org/10.1186/s12876-018-0737-7
|
[
"colon",
"blood",
"computed",
"tomography",
"mesenteric",
"abdominal",
"administration",
"layer",
"hospitalization",
"range"
] |
[
{
"code": "1A40.0&XA03U9",
"title": "Colon inflammation"
},
{
"code": "DB30.Y&XA03U9",
"title": "Obstructed colon"
},
{
"code": "NB91.81",
"title": "Laceration of colon"
},
{
"code": "DD3Z",
"title": "Ischaemic vascular disorders of intestine, unspecified"
},
{
"code": "DB32.2Z&XA03U9",
"title": "Colonic dilatation"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
}
] |
=== ICD-11 CODES FOUND ===
[NB91.81] Laceration of colon
Definition: A tear or wound of large intestine.
Also known as: Laceration of colon
[DD3Z] Ischaemic vascular disorders of intestine, unspecified
Also known as: Ischaemic vascular disorders of intestine, unspecified | Vascular disorder of intestine, not elsewhere classified | vascular disorder of intestine | vascular bowel disease | ischaemic gut NOS
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
=== GRAPH WALKS ===
--- Walk 1 ---
[NB91.81] Laceration of colon
Def: A tear or wound of large intestine....
--PARENT--> [NB91.8] Injury of colon
--CHILD--> [NB91.82] Primary blast injury of colon
Def: An injury to large intestine resulting from direct or indirect exposure to explosion. Primary injuries are caused by high-order explosives or shock waves....
--- Walk 2 ---
[NB91.81] Laceration of colon
Def: A tear or wound of large intestine....
--PARENT--> [NB91.8] Injury of colon
--CHILD--> [NB91.82] Primary blast injury of colon
Def: An injury to large intestine resulting from direct or indirect exposure to explosion. Primary injuries are caused by high-order explosives or shock waves....
--- Walk 3 ---
[DD3Z] Ischaemic vascular disorders of intestine, unspecified
--PARENT--> [?] Ischaemic vascular disorders of intestine
Def: Intestinal ischemia characterised by blood supply to the gastrointestinal tract that is inadequate to meet its metabolic demand...
--EXCLUDES--> [?] Necrotising enterocolitis of newborn
Def: This is a fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal haemorrhage, and necrosis usually of the right colon, caecum, terminal il...
--- Walk 4 ---
[DD3Z] Ischaemic vascular disorders of intestine, unspecified
--PARENT--> [?] Ischaemic vascular disorders of intestine
Def: Intestinal ischemia characterised by blood supply to the gastrointestinal tract that is inadequate to meet its metabolic demand...
--CHILD--> [DD31] Chronic vascular disorders of intestine
|
[
"[NB91.81] Laceration of colon\n Def: A tear or wound of large intestine....\n --PARENT--> [NB91.8] Injury of colon\n --CHILD--> [NB91.82] Primary blast injury of colon\n Def: An injury to large intestine resulting from direct or indirect exposure to explosion. Primary injuries are caused by high-order explosives or shock waves....",
"[NB91.81] Laceration of colon\n Def: A tear or wound of large intestine....\n --PARENT--> [NB91.8] Injury of colon\n --CHILD--> [NB91.82] Primary blast injury of colon\n Def: An injury to large intestine resulting from direct or indirect exposure to explosion. Primary injuries are caused by high-order explosives or shock waves....",
"[DD3Z] Ischaemic vascular disorders of intestine, unspecified\n --PARENT--> [?] Ischaemic vascular disorders of intestine\n Def: Intestinal ischemia characterised by blood supply to the gastrointestinal tract that is inadequate to meet its metabolic demand...\n --EXCLUDES--> [?] Necrotising enterocolitis of newborn\n Def: This is a fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal haemorrhage, and necrosis usually of the right colon, caecum, terminal il...",
"[DD3Z] Ischaemic vascular disorders of intestine, unspecified\n --PARENT--> [?] Ischaemic vascular disorders of intestine\n Def: Intestinal ischemia characterised by blood supply to the gastrointestinal tract that is inadequate to meet its metabolic demand...\n --CHILD--> [DD31] Chronic vascular disorders of intestine"
] |
1A40.0&XA03U9
|
Colon inflammation
|
[
{
"from_icd11": "DD3Z",
"icd10_code": "K559",
"icd10_title": "Vascular disorder of intestine, unspecified"
},
{
"from_icd11": "DD3Z",
"icd10_code": "K558",
"icd10_title": "Other vascular disorders of intestine"
},
{
"from_icd11": "DD3Z",
"icd10_code": "K55-K64",
"icd10_title": ""
},
{
"from_icd11": "DD3Z",
"icd10_code": "K55",
"icd10_title": "Vascular disorders of intestine"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
}
] |
K559
|
Vascular disorder of intestine, unspecified
|
A peripheral blood film noted microcytic and hypochromic red blood cells without the presence of teardrop poikilocytes, schistocytes, blasts, or other morphologically diagnostic or sinister findings . No monoclonal paraprotein was found, Parvovirus-B19 serology was negative, and haemoglobin electrophoresis did not suggest the presence of a hemoglobinopathy. Hepatitis B, Hepatitis C, and HIV serology were negative. Aside from a low-titre anti-nuclear antigen antibodies (ANA) of 1:80, serum autoantibodies including antineutrophil cytoplasmic antibodies (ANCA), extractable nuclear antigen antibodies (ENA), and rheumatoid factor were all negative. His progressive, and symptomatic, bicytopenia (haemoglobin 85 g/L, platelets 38 X 10^9/L) requiring intermittent transfusions of packed red blood cells prompted a bone marrow aspirate and trephine. This identified a hypercellular marrow with increased granulopoiesis, reduced erythropoiesis, megakaryocyte clustering and dysplasia in association with grade 2 fibrosis . A subsequent JAK2 V617F, CALR, and MPL mutation analysis was negative. With the renal function deteriorating, a kidney biopsy was performed with simultaneous platelet transfusion. Light microscopy showed mild expansion of the mesangial matrix, with increased endocapillary cellularity of the glomeruli , with variable thickening of the capillary walls and patchy double contour changes. There were no thrombi, sclerosing or necrotising lesions. Additionally, there was no tubular atrophy, interstitial fibrosis, or interstitial inflammation, and no features suggestive of an arteritis, vasculitis, or cholesterol emboli . Congo red staining was negative. Immunofluorescence and C4d staining were unremarkable. The overall appearance of the biopsy was in keeping with an atypical thrombotic microangiopathy. The electron microscopy had significant reprocessing artefact but excluded immune-complex deposition, and demonstrated an expanded mesangium occupied by swollen cells and diffuse glomerular basement membrane (GBM) thickening. . Oligo-anuria with worsening pulmonary oedema prompted the initiation of haemodialysis at a creatinine peak of 531 μmol/L. A whole-body PET scan noted low metabolically active nodal disease above and below the diaphragm (SUV max 4.2), diffuse metabolic activity throughout the bone marrow and spleen, as well as pleural effusions, a pericardial effusion and abdominal ascites. A decision was made to forego a lymph node biopsy as the patient already fulfilled criteria for a diagnosis of TAFRO syndrome (meeting all 3 of the major criteria, and 3 of the 4 minor criteria), having excluded other possible haematologic and autoimmune conditions, 2 weeks into his hospital admission. Pulse intravenous methylprednisolone was administered over 3 consecutive days, followed by daily oral prednisolone therapy. Although the HHV8 PCR was negative, the initial Interleukin-6 (IL-6) sample was not collected in the appropriate manner with the repeat sample being sent 1 week after initiation of methylprednisolone. This made the result (< 2.1 pg/mL) difficult to interpret. The renal dysfunction improved rapidly upon steroid initiation, with only 4 sessions of dialysis required during the admission. After 25 days in hospital, and 9 doses of glucocorticoid, the creatinine had improved to 165 μmol/L, with a persistent bicytopenia (Hb 105 g/L, Plts 51 X 10^9/L). After discharge, the patient received 800 mg of intravenous rituximab (375 mg/m 2 ) administered weekly over 4 weeks, with the prednisolone weaned gradually. Over 6 months of follow-up, the bicytopenia resolved (Hb 135 g/L, Plts 246 X 10^9/L) and the renal function stabilised with a creatinine of 100–110 μmol/L, eGFR 70–75 mL/Min/1.73m 2 , without proteinuria. Repeat testing of VEGF and IL-6 10 months from the initial presentation confirmed elevated levels of 1155 ng/L, and 410.0 ng/L, respectively. Given these results, an IL-6 inhibitor, siltuximab, was initiated. Fig. 1 Hematologic Investigations: A ) peripheral blood film – mild anisocytosis, hypersegmented neutrophils (black arrow), occasional giant platelets (asterisk) B ) Bone Marrow Trephine (H&E stain) – hypercellular with normal lamellar bone C ) Bone Marrow Trephine (CD61) – Megakaryocyte clustering and dysplasia. D ) Bone Marrow Trephine (Reticulin) – consistent with grade 2 fibrosis (black arrows) Fig. 2 Renal Biopsy: A ) Tubulointerstitium (H&E stain) - no significant interstitial fibrosis, tubular atrophy, or interstitial inflammation. B ) Glomerulus (H&E stain) - mild expansion of mesangial matrix with patch endocapillary cellularity (black asterisks) and focal double contours (black arrows). No thrombi, sclerosing lesions, or necrotising lesions. C ) Artery (H&E stain) – normal thickness with no fibrointimal hyperplasia or hylanosis. No evidence of arteritis, vasculitis or cholesterol emobli. D ) Electron micrograph – swollen mesangial cells (white asterisks) with no electron-dense deposits or abnormal fibrils. Diffuse glomerular basement membrane thickening (white arrow). Tubules, interstitium, and vessels predominantly normal
| 4.1875
| 0.95752
|
sec[1]/p[1]
|
en
| 0.999997
|
34991522
|
https://doi.org/10.1186/s12882-022-02660-7
|
[
"bone",
"marrow",
"blood",
"cells",
"trephine",
"fibrosis",
"renal",
"biopsy",
"interstitial",
"black"
] |
[
{
"code": "FC0Z",
"title": "Diseases of the musculoskeletal system or connective tissue, unspecified"
},
{
"code": "FB84.Z",
"title": "Osteomyelitis or osteitis, unspecified"
},
{
"code": "FB80.Z",
"title": "Disorder of bone density or structure, unspecified"
},
{
"code": "FB86.11",
"title": "Hypertrophy of bone"
},
{
"code": "FB86.1Z",
"title": "Bone hyperplasias, unspecified"
},
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "3A70.Z",
"title": "Aplastic anaemia, unspecified"
},
{
"code": "3C0Y",
"title": "Other specified diseases of the blood or blood-forming organs"
},
{
"code": "3A70.12",
"title": "Idiopathic aplastic anaemia"
},
{
"code": "NE84",
"title": "Failure or rejection of transplanted organs or tissues"
}
] |
=== ICD-11 CODES FOUND ===
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
Also known as: Diseases of the musculoskeletal system or connective tissue, unspecified | bone disease NOS | bone disorder NOS | bone lesion NOS | musculoskeletal complications NOS
[FB84.Z] Osteomyelitis or osteitis, unspecified
Also known as: Osteomyelitis or osteitis, unspecified | Osteomyelitis or osteitis | bone inflammation | bone ulcer | bone inflammatory disease
[FB80.Z] Disorder of bone density or structure, unspecified
Also known as: Disorder of bone density or structure, unspecified | Certain specified disorders of bone density or structure
[FB86.11] Hypertrophy of bone
Also known as: Hypertrophy of bone | bone thickening | periosteum thickening | Infantile cortical hyperostoses | Post traumatic subperiosteal ossification
[FB86.1Z] Bone hyperplasias, unspecified
Also known as: Bone hyperplasias, unspecified | Bone hyperplasias
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[3A70.Z] Aplastic anaemia, unspecified
Also known as: Aplastic anaemia, unspecified | Aplastic anaemia | erythroid aplasia | AA - [aplastic anaemia] | haematopoietic aplasia
[3C0Y] Other specified diseases of the blood or blood-forming organs
Also known as: Other specified diseases of the blood or blood-forming organs | Congenital anomaly blood or lymph other | Blood dyscrasia | blood dyscrasia NOS | Bone marrow hyperplasia
[3A70.12] Idiopathic aplastic anaemia
Also known as: Idiopathic aplastic anaemia | Idiopathic bone marrow failure | idiopathic aplastic anaemia NOS
[NE84] Failure or rejection of transplanted organs or tissues
Also known as: Failure or rejection of transplanted organs or tissues | organ transplant rejection | transplant failure | transplant rejection | Bone-marrow transplant rejection
=== GRAPH WALKS ===
--- Walk 1 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes
Def: !markdown
In the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...
--- Walk 2 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 3 ---
[FB84.Z] Osteomyelitis or osteitis, unspecified
--PARENT--> [FB84] Osteomyelitis or osteitis
--CHILD--> [FB84.0] Acute haematogenous osteomyelitis
--- Walk 4 ---
[FB84.Z] Osteomyelitis or osteitis, unspecified
--PARENT--> [FB84] Osteomyelitis or osteitis
--CHILD--> [FB84.1] Other acute osteomyelitis
--- Walk 5 ---
[FB80.Z] Disorder of bone density or structure, unspecified
--PARENT--> [FB80] Certain specified disorders of bone density or structure
--EXCLUDES--> [?] Osteopoikilosis
--- Walk 6 ---
[FB80.Z] Disorder of bone density or structure, unspecified
--PARENT--> [FB80] Certain specified disorders of bone density or structure
--CHILD--> [FB80.0] Fibrous dysplasia of bone
Def: Fibrous dysplasia of bone is a congenital non-hereditary benign bone disease, where normal bone is replaced by a fibrous-like tissue with immature osteogenesis. Bone lesions are mono- or polyostotic a...
|
[
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --EXCLUDES--> [?] Injury, poisoning or certain other consequences of external causes\n Def: !markdown\nIn the ICD, injury means physical or physiological bodily harm resulting from interaction of the body with energy (mechanical, thermal, electrical, chemical or radiant, or due to extreme pre...",
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[FB84.Z] Osteomyelitis or osteitis, unspecified\n --PARENT--> [FB84] Osteomyelitis or osteitis\n --CHILD--> [FB84.0] Acute haematogenous osteomyelitis",
"[FB84.Z] Osteomyelitis or osteitis, unspecified\n --PARENT--> [FB84] Osteomyelitis or osteitis\n --CHILD--> [FB84.1] Other acute osteomyelitis",
"[FB80.Z] Disorder of bone density or structure, unspecified\n --PARENT--> [FB80] Certain specified disorders of bone density or structure\n --EXCLUDES--> [?] Osteopoikilosis",
"[FB80.Z] Disorder of bone density or structure, unspecified\n --PARENT--> [FB80] Certain specified disorders of bone density or structure\n --CHILD--> [FB80.0] Fibrous dysplasia of bone\n Def: Fibrous dysplasia of bone is a congenital non-hereditary benign bone disease, where normal bone is replaced by a fibrous-like tissue with immature osteogenesis. Bone lesions are mono- or polyostotic a..."
] |
FC0Z
|
Diseases of the musculoskeletal system or connective tissue, unspecified
|
[
{
"from_icd11": "FC0Z",
"icd10_code": "XIII",
"icd10_title": ""
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86672",
"icd10_title": "Other chronic osteomyelitis, left ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86172",
"icd10_title": "Other acute osteomyelitis, left ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86171",
"icd10_title": "Other acute osteomyelitis, right ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86671",
"icd10_title": "Other chronic osteomyelitis, right ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X7",
"icd10_title": "Other osteomyelitis, ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X8",
"icd10_title": "Other osteomyelitis, other site"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X6",
"icd10_title": "Other osteomyelitis, lower leg"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X9",
"icd10_title": "Other osteomyelitis, unspecified sites"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M8668",
"icd10_title": "Other chronic osteomyelitis, other site"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86662",
"icd10_title": "Other chronic osteomyelitis, left tibia and fibula"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86151",
"icd10_title": "Other acute osteomyelitis, right femur"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86141",
"icd10_title": "Other acute osteomyelitis, right hand"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86641",
"icd10_title": "Other chronic osteomyelitis, right hand"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M8669",
"icd10_title": "Other chronic osteomyelitis, multiple sites"
}
] |
XIII
| |
A 36-year-old Japanese man with a 14-month history of HIV infection presented with fever, pulsating headache, lumbago, nausea, and vomiting four week prior to his admission. Although highly active anti-retroviral therapy (HAART) had been started (lamivudine, azidothymidine, and lopinavir plus ritonavir) after completion of treatment for pneumocystis pneumonia, which had been the initial clinical manifestation of our patient, his CD4-positive lymphocyte counts in peripheral blood has never recovered to more than 200 cells/mm 3 . Therefore, three months before admission, abacavir was given instead of azidothymidine, but was also insufficient for increasing CD4-positive lymphocytes. Furthermore, according to the guidelines, prophylaxis against Pneumocystis jirovecii had been started. In our case, atovaquone had been administered, because sulfamethoxazole-trimethoprim and pentamidine had caused hepatic and renal insufficiency, respectively. On physical examination, our patient reported headache with neck stiffness. His axillary temperature was 38.2°C. Chest radiography and computed tomography (CT) of the brain showed no abnormalities. He was diagnosed as purulent meningitis, initially, because of an increasing of neutrophils count in cerebrospinal fluid (CSF). Broad-spectrum antimicrobials, however, had no effect on this meningitis. CD4-positive lymphocyte counts 146/μl in peripheral blood. He did not show increasing of immunoglobulin G (IgG) and immunoglobulin M (IgM) fraction of anti-T. gondii antibody (enzyme-linked immunosorbant assay, ELISA). Three weeks after admission, due to worsened headache and lumbago, magnetic resonance imaging (MRI) of the brain and lumbar vertebrae was performed and showed enhanced small nodules at right superior pons and bilateral superior cerebellum, peripheral enhancement at the bilateral superior pons, and enhanced lesions which was parallel to left inner ear. These findings strongly suggested meningitis with granuloma formation, such as tuberculosis. Furthermore, MRI of the lumber vertebrae also suggested the presence of the granulomatous lesion. However, the PCR assay targeting mycobacterium tuberculosis was negative. Therefore, bone marrow aspiration biopsy was performed for histopathological examination to elucidate the causative agent of generalized infection. The specimen, bone marrow aspiration clot, was fixed with 10% formalin and embedded in paraffin wax after dehydration which was cut into 3 μm-thick sections, and routinely stained with hematoxylin and eosin double stain. Histopathological examination indicated hypocellular bone marrow in which clustered intra-cellular basophilic granuli were present . These were confirmed as microcalcification by Von Kossa's stain. Therefore, the PCR assay with toxoplasma-specific primer was performed using nucleic acid extracted from the formalin-fixed and paraffin-embedded tissue (bone marrow aspiration) section. In the procedure, paraffin-embedded tissue sections (bone marrow aspiration clot) were deparaffinized by xylene and immersed in absolute ethanol. The air-dried pellets of dehydrated section were then resuspended in extraction buffer (Tris-HCl [50 mM, pH 8.5], NaCl [50 mM], EDTA [10 mM], sodium dodecyl sulfate [0.5%], proteinase K [10 mg/mL]) at 95°C. The samples were completely submerged in the extraction buffer and incubated at 56°C for 12 hours. The supernatant was then purified by phenol-chloroform extraction and ethanol precipitation, and was resuspended in 25 mL of DNase-free buffer (Tris-HCl [10 mM], EDTA [1 mM]), and was stored at 20°C until use for DNA amplification. PCR for B1 gene of T. gondii was carried out following the previous description of Tachikawa et al. . The primers used in the assay are summarized in Additional file 1 . Conditions of nested PCR for T. gondii were 0.5 pmol/L primer, 2.5 mM MgCl 2 , 0.2 mM dNTP, and 0.02 U/L Taq DNA polymerase. First PCR was performed in thermal cycler starting with a pre-incubation at 94°C for three minutes, followed by 40 PCR cycles of one minute denaturation at 94°C, one minute annealing at 58°C, one minute elongation at 72°C. The first PCR product was added to a new reaction mixture. Compositions and PCR cycles were same as the first PCR. Second PCR product was electrophoresed on a 3% agarose gel. As a result, the specific PCR product of T. gondii was obtained from the extract from paraffin-embedded tissue sections of the bone marrow biopsy . Anti -T. gondii therapy consisting of pyrimethamine, clindamycin, and leucovorin had been started. After sulfadiazine desensitization, clindamycin was replaced with sulfadiazine. Together with this, although our patient was negative on frequent PCR assay for tuberculosis, anti-tubercular treatment had been continued due to suspected tuberculosis from MRI. According to this, his fever was improved, but other clinical symptoms remained. Finally, anti -T. gondii therapy consisting pyrimethamine, sulfadiazine, and leucovorin plus prednisolone had an effect on improving his clinical symptoms and he was referred to other hospital in his home city at his request.
| 4.199219
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|
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|
en
| 0.999998
|
20701779
|
https://doi.org/10.1186/1752-1947-4-265
|
[
"gondii",
"bone",
"marrow",
"anti",
"assay",
"which",
"tuberculosis",
"aspiration",
"embedded",
"paraffin"
] |
[
{
"code": "1F57.Y/GB5Z",
"title": "Renal tubulo-interstitial disorders due to toxoplasmoa gondii"
},
{
"code": "1F57.2",
"title": "Pulmonary toxoplasmosis due to Toxoplasma gondii"
},
{
"code": "1F57.3",
"title": "Eye disease due to Toxoplasma gondii"
},
{
"code": "1F57.Z",
"title": "Toxoplasmosis, unspecified"
},
{
"code": "1F57.1",
"title": "Meningoencephalitis due to Toxoplasma gondii"
},
{
"code": "FC0Z",
"title": "Diseases of the musculoskeletal system or connective tissue, unspecified"
},
{
"code": "FB84.Z",
"title": "Osteomyelitis or osteitis, unspecified"
},
{
"code": "FB80.Z",
"title": "Disorder of bone density or structure, unspecified"
},
{
"code": "FB86.11",
"title": "Hypertrophy of bone"
},
{
"code": "FB86.1Z",
"title": "Bone hyperplasias, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii
Definition: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, or cytotoxic drugs and those with hematologic malignancies, organ transplants, or acquired immunodeficiency syndrome (AIDS).
Pulmonary toxoplasmosis in the immunodeficient patient may appear in the form of interstitial pneumonitis, necrotizing pneumonitis, consolidation, pleural effusion, or empyema
Also known as: Pulmonary toxoplasmosis due to Toxoplasma gondii | pneumonia with toxoplasmosis | pneumonitis due to acquired toxoplasmosis | pneumonitis due to toxoplasmosis | toxoplasma pneumonia
Includes: Pulmonary toxoplasmosis
[1F57.3] Eye disease due to Toxoplasma gondii
Definition: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tachyzoites. Focal necrotizing retinitis is the characteristic lesion, but retinal scars from prior reactivation are typically present.
Also known as: Eye disease due to Toxoplasma gondii | Toxoplasma oculopathy | Toxoplasma posterior uveitis | Toxoplasma chorioretinitis | chorioretinitis due to toxoplasmosis
Includes: Toxoplasma oculopathy
[1F57.Z] Toxoplasmosis, unspecified
Also known as: Toxoplasmosis, unspecified | Toxoplasmosis | acquired toxoplasmosis | toxoplasmosis disease or disorder | infection by toxoplasma gondii
[1F57.1] Meningoencephalitis due to Toxoplasma gondii
Definition: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations in behaviour, cognition, or consciousness. Transmission is by haematogenous spread to the meninges and brain after direct ingestion of contaminated food, or indirect transmission by consumption of food or water contaminated with infected cat faeces. Confirmation is by detection of antibodies against
Also known as: Meningoencephalitis due to Toxoplasma gondii | acquired toxoplasmal meningoencephalitis | meningoencephalitis due to acquired toxoplasmosis | meningoencephalitis due to toxoplasmosis | Toxoplasma meningoencephalitis
Includes: Toxoplasma meningoencephalitis
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
Also known as: Diseases of the musculoskeletal system or connective tissue, unspecified | bone disease NOS | bone disorder NOS | bone lesion NOS | musculoskeletal complications NOS
[FB84.Z] Osteomyelitis or osteitis, unspecified
Also known as: Osteomyelitis or osteitis, unspecified | Osteomyelitis or osteitis | bone inflammation | bone ulcer | bone inflammatory disease
[FB80.Z] Disorder of bone density or structure, unspecified
Also known as: Disorder of bone density or structure, unspecified | Certain specified disorders of bone density or structure
[FB86.11] Hypertrophy of bone
Also known as: Hypertrophy of bone | bone thickening | periosteum thickening | Infantile cortical hyperostoses | Post traumatic subperiosteal ossification
[FB86.1Z] Bone hyperplasias, unspecified
Also known as: Bone hyperplasias, unspecified | Bone hyperplasias
=== GRAPH WALKS ===
--- Walk 1 ---
[1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii
Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii
Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...
--- Walk 2 ---
[1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii
Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii
Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...
--- Walk 3 ---
[1F57.3] Eye disease due to Toxoplasma gondii
Def: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tac...
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii
Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...
--- Walk 4 ---
[1F57.3] Eye disease due to Toxoplasma gondii
Def: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tac...
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--CHILD--> [1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii
Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...
--- Walk 5 ---
[1F57.Z] Toxoplasmosis, unspecified
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--RELATED_TO--> [?] Congenital toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii in utero. This disease is characterised by chorioretinitis, hydrocephalus, intracranial calcifications, anaemia, or neuro...
--- Walk 6 ---
[1F57.Z] Toxoplasmosis, unspecified
--PARENT--> [1F57] Toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...
--RELATED_TO--> [?] Congenital toxoplasmosis
Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii in utero. This disease is characterised by chorioretinitis, hydrocephalus, intracranial calcifications, anaemia, or neuro...
|
[
"[1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii\n Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii\n Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...",
"[1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii\n Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii\n Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...",
"[1F57.3] Eye disease due to Toxoplasma gondii\n Def: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tac...\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --CHILD--> [1F57.1] Meningoencephalitis due to Toxoplasma gondii\n Def: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations i...",
"[1F57.3] Eye disease due to Toxoplasma gondii\n Def: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tac...\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --CHILD--> [1F57.2] Pulmonary toxoplasmosis due to Toxoplasma gondii\n Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...",
"[1F57.Z] Toxoplasmosis, unspecified\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --RELATED_TO--> [?] Congenital toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii in utero. This disease is characterised by chorioretinitis, hydrocephalus, intracranial calcifications, anaemia, or neuro...",
"[1F57.Z] Toxoplasmosis, unspecified\n --PARENT--> [1F57] Toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of cont...\n --RELATED_TO--> [?] Congenital toxoplasmosis\n Def: A disease caused by an infection with the protozoan parasite Toxoplasma gondii in utero. This disease is characterised by chorioretinitis, hydrocephalus, intracranial calcifications, anaemia, or neuro..."
] |
1F57.Y/GB5Z
|
Renal tubulo-interstitial disorders due to toxoplasmoa gondii
|
[
{
"from_icd11": "1F57.2",
"icd10_code": "B583",
"icd10_title": "Pulmonary toxoplasmosis"
},
{
"from_icd11": "1F57.3",
"icd10_code": "B5800",
"icd10_title": "Toxoplasma oculopathy, unspecified"
},
{
"from_icd11": "1F57.3",
"icd10_code": "B580",
"icd10_title": "Toxoplasma oculopathy"
},
{
"from_icd11": "1F57.Z",
"icd10_code": "B5889",
"icd10_title": "Toxoplasmosis with other organ involvement"
},
{
"from_icd11": "1F57.Z",
"icd10_code": "B589",
"icd10_title": "Toxoplasmosis, unspecified"
},
{
"from_icd11": "1F57.Z",
"icd10_code": "B58",
"icd10_title": "Toxoplasmosis"
},
{
"from_icd11": "1F57.Z",
"icd10_code": "B588",
"icd10_title": "Toxoplasmosis with other organ involvement"
},
{
"from_icd11": "1F57.1",
"icd10_code": "B582",
"icd10_title": "Toxoplasma meningoencephalitis"
},
{
"from_icd11": "FC0Z",
"icd10_code": "XIII",
"icd10_title": ""
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86672",
"icd10_title": "Other chronic osteomyelitis, left ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86172",
"icd10_title": "Other acute osteomyelitis, left ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86171",
"icd10_title": "Other acute osteomyelitis, right ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M86671",
"icd10_title": "Other chronic osteomyelitis, right ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X7",
"icd10_title": "Other osteomyelitis, ankle and foot"
},
{
"from_icd11": "FB84.Z",
"icd10_code": "M868X8",
"icd10_title": "Other osteomyelitis, other site"
}
] |
B583
|
Pulmonary toxoplasmosis
|
We present a 32-year-old woman referred to the hospital due to facial swelling and shortness of breath. Her lower left incisor, molar, and premolar teeth were extracted at a private dentist's office at 8 p.m. On the next day, at 10 a.m., she woke up with pain in the left jaw and swelling that gradually expanded to the left side of her cheek and neck until, at noon (2 p.m.), she reported experiencing shortness of breath after walking approximately 100 m, which caused her to stop and catch her breath before continuing, hoarseness, and fever, and she reached out to the hospital. She had a history of polycystic ovaries but mentioned no medical history in her family. Upon admission, she denied using any drugs, either daily or after the dental surgery. Her blood pressure was 160/80 mmHg, respiratory rate was 28 per minute, pulse rate was 125 beats per minute, and body temperature was 38 °C. She had an oxygen saturation (SpO2) of 58% in the room air, which increased to 85% after receiving 100% oxygen via a reservoir bag and being placed in a sitting position. In the physical examination, her appearance showed swelling and local heat in the left temporomandibular joint (TMJ) and masseter, and her face was asymmetrical. Upon examining the patient's oral cavity, she had poor oral hygiene, and other teeth on the right side required dental treatment. A tooth located in the upper right molar area had been extracted, and the space was empty. Her left mandibular region was tender, and two mobile, tender lymph nodes were palpable in the left submandibular and anterior cervical regions with an approximate size of 1.5 × 1.5 cm. In lung auscultation, crackles and decreased breathing sounds were detectable in the base of the lungs. Due to her condition, she was immediately transferred to the intensive care unit (ICU). The arterial blood gas analysis (ABG) at the ICU showed PH 7.25, PaO2 81%, PaCO2 43.2, and HCO3 18.1. She suddenly experienced tachycardia, increased respiratory rate, cyanosis, gasping respiration, use of accessory muscles, hypoxemia, and her SpO2 decreased to 75% with 100% o2 with the reservoir bag mask; her auscultation showed diffuse wheeze and crackle along with reduced breath sounds in lower lungs. This sudden worsening of her condition led to intubation. The patient was intubated after receiving 100 mcg of fentanyl and 2 mg of midazolam. During intubation, the operator claims proximity of the vocal cords and bucking during the endotracheal tube (ETT) passage, along with pink and frothy secretions coming out of the ETT. Her Spo2 after intubation, despite receiving Fio2 100%, increased to 85%. A lung CT scan showed bilateral pleural effusion and patchy ground glass opacities . These findings suggested a viral or bacterial infection, cardiogenic pulmonary edema, or non-cardiogenic pulmonary edema as differential diagnoses. The treatment began with 40 mg of furosemide amp as a bolus dose and then an infusion of 8 mg/hr., 1 g of vancomycin amp two times a day, and 600 mg of clindamycin three times a day. During her cardiac consultation and echocardiography, the cardiologist reported an ejection fraction of 55%, a pulmonary artery pressure (PAP) of 42 mm Hg, and up to moderate posterior mitral valve regurgitation. The cardiologist expressed that cardiac pathologies were less likely based on these findings. All workups for connective tissue diseases, vasculitis, COVID-19, and influenza were negative ( Table 1 ). Fig. 1 Patient's chest Imaging. a, b, chest CT scan at the first day of admission after laryngospasm displaying bilateral pleural effusion (Blue arrow) and bilateral ground glass opacities (Red arrow). c, d, chest radiography at the second and third day of admission. Fig. 1 Table 1 The laboratory results of the patient during her admission. Table 1 Lab tests Normal range Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 WBC count, count/mm 4000–10000 10.100 9900 5800 Hemoglobin, mg/dl 12–15 13.6 11.6 12.4 MCV, fl 80–96 87 85 85 ESR, mm/hr >21 26 CRP Neg Neg. Platelet, count/mm 150000–450000 303.000 216.000 BUN, mg/dl 15–45 56 55 62 61 62 59 Cr, mg/dl 0.5–1.4 1.1 1.3 1.2 1.5 1.2 1.2 INR 1–1.4 1.1 1.3 Troponin, ng/mL 0–0.04 0.039 0.03 TSH, micIU/ml 0.35–4.94 1.2 2.3 LDH, U/L 0–500 539 AST, IU/l <41 20 ALT, IU/l <41 24 CPK, mcg/L 0–120 185 ALP, IU/l 120 ds-DNA Neg. Neg. Blood culture Neg. Neg. Urine culture Neg. Neg. C3, mg/dl 75 to 175 113.8 C4, mg/dl 16 to 48 22 CH50, U/mL 42 to 95 110 ANA <0.5 0.1 P-ANCA Neg. Neg. C-ANCA Neg. Neg. D-dimer Neg. Neg. 24 hr. urine Cr. Pr. Vol. 13.2 592 1600 WBC : White blood cells; Hb: Hemoglobin MCV : Mean corpuscular volume; LDH : Lactate dehydrogenase; Cr : Creatinine; CRP : C-reactive protein; ESR : Erythrocyte sedimentation rate; INR : International normalized ratio; PTT : Partial thromboplastin time; BUN : Blood urea nitrogen; TSH : Thyroid-stimulating hormone; AST : Aspartate aminotransferase; ALT : Alanine aminotransferase; ALP : Alkaline phosphatase; CPK : Creatinine phosphokinase ; ANA : Anti-nuclear antibody; ANCA : Antineutrophil cytoplasmic antibodies; ds-DNA : Double stranded deoxyribonucleic acid.
| 3.878906
| 0.981445
|
sec[1]/p[0]
|
en
| 0.999995
|
38571620
|
https://doi.org/10.1016/j.heliyon.2024.e28470
|
[
"blood",
"breath",
"swelling",
"receiving",
"intubation",
"pulmonary",
"chest",
"count",
"anca",
"shortness"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "MD11.Z",
"title": "Abnormalities of breathing, unspecified"
},
{
"code": "MD11.Y",
"title": "Other specified abnormalities of breathing"
},
{
"code": "MD11.5",
"title": "Dyspnoea"
},
{
"code": "MD11.7",
"title": "Hyperventilation"
},
{
"code": "MD11.8Z",
"title": "Mouth breathing, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[MD11.Z] Abnormalities of breathing, unspecified
Also known as: Abnormalities of breathing, unspecified | Abnormalities of breathing | abnormal respiration | abnormal breath sounds | abnormal respiratory rate
[MD11.Y] Other specified abnormalities of breathing
Also known as: Other specified abnormalities of breathing | Bradypnoea | Choking sensation | Hypoventilation | hypoventilation syndrome NOS
[MD11.5] Dyspnoea
Definition: Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a presenting complaint of patients with a wide variety of medical diseases by multiple mechanisms.
Dyspnoea is considered acute when it lasts from hours up to 3 weeks, subacute from 3 weeks up to 8 weeks, and chronic dyspnoea lasts more than 8 weeks.
Also known as: Dyspnoea | difficulty breathing | respiration difficult | short of breath | winded
Includes: Orthopnoea
Excludes: Transient tachypnoea of newborn
[MD11.7] Hyperventilation
Definition: Hyperventilation refers to an increase in the rate of alveolar ventilation that is excessive for the rate of metabolic carbon dioxide production, resulting in a decrease in arterial PCO2 to below the normal range of 37 to 43 mm Hg. Hyperventilation should be distinguished from tachypnoea, an increase in respiratory frequency, and from hyperpnea, an increase in minute volume of ventilation.
Also known as: Hyperventilation | hyperventilating | overbreathing | HV - [hyperventilation] | increased respiratory rate
[MD11.8Z] Mouth breathing, unspecified
Also known as: Mouth breathing, unspecified | Mouth breathing | breathing orally | mouth respiration
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.4Z] Haematuria, unspecified
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.4Z] Haematuria, unspecified
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.4Z] Haematuria, unspecified",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.4Z] Haematuria, unspecified",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --PARENT--> [?] Clinical findings in blood, blood-forming organs, or the immune system",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
We present the case of a 54-year-old male patient, suffering from headache since childhood. His family history is positive for migraine and his past medical history includes a head trauma occurred when he was 3 years old. During the years, the patient has presented two types of headache with variable frequency: migraine without aura since school-age, and a disabling tension-type headache, started in adulthood. Sleep deprivation, alcohol, traveling represent his main trigger factors. His clinical history is summarized in Figure 1 . Since 2008, his migraine became “chronic” according to ICHD-3beta version definition ( 1 ). At that time, neurological examination was normal and brain MRI showed two subcortical small high T2-weighted lesions, diagnosed as aspecific gliosis. To counteract this chronic headache, he has been prescribed several preventive therapies including topiramate, sodium valproate, propranolol, flunarizine, amitriptyline at the recommended therapeutic dosage according to guidelines ( 2 ). In most cases, the patient reported a transient benefit on headache frequency and intensity, lasting only few months. He treated acute episodes with multiple painkillers, i.e., triptans and nonsteroidal anti-inflammatory drugs (NSAIDs), up to five symptomatic drugs per attack. Hence, he was also diagnosed a medication overuse headache (MOH). In 2009, the patient underwent a first detoxification treatment with glutathione, cyanocobalamin, folic acid, nicotinamide, ascorbic acid, delorazepam, and metoclopramide, without any benefit. In 2010, our headache center started taking care of the patient. At that time, he suffered from chronic migraine and MOH. The most effective symptomatic drug was indomethacin 50 mg, which he took almost on a daily basis. He underwent a second detoxification treatment with intravenous steroids (prednisone) and diazepam at our hospital. The treatment was effective only for few weeks, then migraine returned chronic and the patient resumed to abuse symptomatic drugs. Moreover, since he had to travel abroad very often, he started experiencing anticipatory fear of suffering from severe headaches, making painkiller and steroid assumption more frequent. Then, the patient received six detoxification treatments with intravenous steroids and diazepam, almost twice per year, until 2015. These treatments were necessary as they provided relief and allowed the patient to attend his work. After each detoxification treatment, a short cycle of oral methylprednisolone and different preventive therapies (i.e., topiramate, amitriptyline, trazodone, propranolol) were prescribed. After a transient improvement, headache returned daily once again. In 2012, he underwent radiofrequency ablation of cervical ganglion without clinical benefit. In 2013, the patient presented a transient global amnesia, brain MRI evidenced an acute hippocampal lesion, transcranial doppler, and echocardiography with bubble test showed a patent foramen ovale with atrial septal aneurysm. We prescribed aspirin 100 mg/day. In 2014, arterial hypertension was diagnosed, so he started taking candesartan 16 mg/day for his additional action in preventing migraine. Given the persistence of headache and failure of the preventive drugs, Onabotulinumtoxin-A treatment was started in September 2014 for 1 year, according to PREEMPT protocol. He still presented 12–13 attacks per month, but a reduction of the headache intensity and, to a lesser extent, of painkillers assumption (i.e., zolmitriptan, indomethacin, paracetamol) was observed. At that time headache-related disability measures showed a HIT-6 score of 64, a MIDAS-score of 70, a headache intensity of 5 out 10 at 11-point Box scale (BS-11). Since the repeated therapeutic attempts led only to minimum benefit, in March 2016, the patient decided, on his own free will, to get a “daith piercing,” which is an ear piercing located at the crus of the helix , bilaterally. At that time, he was on therapy with amitriptyline 25 mg/bid, aspirin 100 mg/day, he suffered from headache at least 15 days per month and took up to 15 painkillers per month. On the following months, he experienced an important reduction of migraine attacks, which returned episodic, and infrequent, less disabling episodes of tension-type headache. Head pain has become less intense than before, with a score of 3 out 10 at BS-11: he describes pain as oppressive and annoying, affecting concentration but rarely interfering with his work and other daily activities (HIT-6 score 56). In addition, he has suffered from headache only 13 days in the last 3 months (MIDAS-score 27) and treated each with a single painkiller. Today, after one and half year, the patient is satisfied and can better attend to his work, traveling and alcohol do not trigger headaches anymore. Migraine attacks are very rare (none in the last 2 months) and he only suffers from infrequent episodic tensive-type headache. He currently takes amitriptyline 25 mg per day. Painkiller assumption is much decreased: he takes only one tablet of indomethacin 50 mg to treat attacks, about four times per month.
| 3.953125
| 0.981445
|
sec[0]/p[0]
|
en
| 0.999996
|
29230190
|
https://doi.org/10.3389/fneur.2017.00624
|
[
"headache",
"migraine",
"since",
"score",
"that",
"time",
"amitriptyline",
"benefit",
"drugs",
"detoxification"
] |
[
{
"code": "MB4D",
"title": "Headache, not elsewhere classified"
},
{
"code": "8A8Z",
"title": "Headache disorders, unspecified"
},
{
"code": "8A8Y",
"title": "Other specified headache disorders"
},
{
"code": "8A82",
"title": "Trigeminal autonomic cephalalgias"
},
{
"code": "8A83",
"title": "Other primary headache disorder"
},
{
"code": "8A80.Z",
"title": "Migraine, unspecified"
},
{
"code": "8A80.Y",
"title": "Other specified migraine"
},
{
"code": "8A80.2",
"title": "Chronic migraine"
},
{
"code": "8A80.1Z",
"title": "Migraine with aura, unspecified"
},
{
"code": "8A80.0",
"title": "Migraine without aura"
}
] |
=== ICD-11 CODES FOUND ===
[MB4D] Headache, not elsewhere classified
Definition: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above.
Also known as: Headache, not elsewhere classified | cephalalgia | cephalgia | cephalodynia | pain in head NOS
Excludes: Trigeminal neuralgia | Atypical facial pain | Acute headache, not elsewhere classified
[8A8Z] Headache disorders, unspecified
Also known as: Headache disorders, unspecified
[8A8Y] Other specified headache disorders
Also known as: Other specified headache disorders
[8A82] Trigeminal autonomic cephalalgias
Definition: A group of related primary headache disorders essentially characterised by unilateral headache and trigeminal autonomic activation. In most but not all of these disorders, the headache is short-lasting and very frequently recurring, but sometimes remitting for long periods.
Also known as: Trigeminal autonomic cephalalgias | Cluster headache | Horton headache | Episodic cluster headache | Chronic cluster headache
[8A83] Other primary headache disorder
Definition: A group of clinically heterogeneous headache disorders, believed to be primary. Although largely unrelated, they fall into four categories: headaches associated with physical exertion; headaches attributed to direct physical but innocuous stimuli; epicranial headaches; and other miscellaneous primary headache disorders.
Also known as: Other primary headache disorder | Primary cough headache | Primary exercise headache | Primary headache associated with sexual activity | Preorgasmic headache
[8A80.Z] Migraine, unspecified
Also known as: Migraine, unspecified | Migraine
[8A80.Y] Other specified migraine
Also known as: Other specified migraine | Episodic syndromes that may be associated with migraine | Recurrent gastrointestinal disturbance | Benign paroxysmal vertigo of childhood | Benign nonfamilial infantile seizures
[8A80.2] Chronic migraine
Definition: Headache occurring on 15 or more days per month for more than three months, which, on at least eight days per month, has the features of migraine headache and is not associated with medication overuse.
Also known as: Chronic migraine
[8A80.1Z] Migraine with aura, unspecified
Also known as: Migraine with aura, unspecified | Migraine with aura | Migraine accompagnée | Complicated migraine | Classical migraine
[8A80.0] Migraine without aura
Definition: Recurrent headache disorder manifesting in attacks lasting 4-72 hours. The duration of attacks may be shorter in children. Typical characteristics of the headache are unilateral location, pulsating quality, moderate or severe intensity, aggravation by routine physical activity and association with nausea and/or photophobia and phonophobia.
Also known as: Migraine without aura | Common migraine | Acute migraine without aura
=== GRAPH WALKS ===
--- Walk 1 ---
[MB4D] Headache, not elsewhere classified
Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....
--EXCLUDES--> [?] Trigeminal neuralgia
Def: Trigeminal neuralgia is a manifestation of orofacial neuropathic pain restricted to one or more divisions of the trigeminal nerve. The pain is recurrent, abrupt in onset and termination, triggered by ...
--CHILD--> [?] Idiopathic trigeminal neuralgia
Def: Idiopathic trigeminal neuralgia is a persistent facial pain that does not have the characteristics of cranial neuralgias and cannot be attributed to a different disorder...
--- Walk 2 ---
[MB4D] Headache, not elsewhere classified
Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....
--EXCLUDES--> [?] Trigeminal neuralgia
Def: Trigeminal neuralgia is a manifestation of orofacial neuropathic pain restricted to one or more divisions of the trigeminal nerve. The pain is recurrent, abrupt in onset and termination, triggered by ...
--CHILD--> [?] Idiopathic trigeminal neuralgia
Def: Idiopathic trigeminal neuralgia is a persistent facial pain that does not have the characteristics of cranial neuralgias and cannot be attributed to a different disorder...
--- Walk 3 ---
[8A8Z] Headache disorders, unspecified
--PARENT--> [?] Headache disorders
--CHILD--> [8A81] Tension-type headache
Def: A primary and highly prevalent headache disorder, in most cases episodic. Attacks of highly variable frequency and duration are characterised by mild-to-moderate headache without associated symptoms, ...
--- Walk 4 ---
[8A8Z] Headache disorders, unspecified
--PARENT--> [?] Headache disorders
--CHILD--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
--- Walk 5 ---
[8A8Y] Other specified headache disorders
--PARENT--> [?] Headache disorders
--EXCLUDES--> [?] Headache, not elsewhere classified
Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....
--- Walk 6 ---
[8A8Y] Other specified headache disorders
--PARENT--> [?] Headache disorders
--CHILD--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
|
[
"[MB4D] Headache, not elsewhere classified\n Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....\n --EXCLUDES--> [?] Trigeminal neuralgia\n Def: Trigeminal neuralgia is a manifestation of orofacial neuropathic pain restricted to one or more divisions of the trigeminal nerve. The pain is recurrent, abrupt in onset and termination, triggered by ...\n --CHILD--> [?] Idiopathic trigeminal neuralgia\n Def: Idiopathic trigeminal neuralgia is a persistent facial pain that does not have the characteristics of cranial neuralgias and cannot be attributed to a different disorder...",
"[MB4D] Headache, not elsewhere classified\n Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....\n --EXCLUDES--> [?] Trigeminal neuralgia\n Def: Trigeminal neuralgia is a manifestation of orofacial neuropathic pain restricted to one or more divisions of the trigeminal nerve. The pain is recurrent, abrupt in onset and termination, triggered by ...\n --CHILD--> [?] Idiopathic trigeminal neuralgia\n Def: Idiopathic trigeminal neuralgia is a persistent facial pain that does not have the characteristics of cranial neuralgias and cannot be attributed to a different disorder...",
"[8A8Z] Headache disorders, unspecified\n --PARENT--> [?] Headache disorders\n --CHILD--> [8A81] Tension-type headache\n Def: A primary and highly prevalent headache disorder, in most cases episodic. Attacks of highly variable frequency and duration are characterised by mild-to-moderate headache without associated symptoms, ...",
"[8A8Z] Headache disorders, unspecified\n --PARENT--> [?] Headache disorders\n --CHILD--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...",
"[8A8Y] Other specified headache disorders\n --PARENT--> [?] Headache disorders\n --EXCLUDES--> [?] Headache, not elsewhere classified\n Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....",
"[8A8Y] Other specified headache disorders\n --PARENT--> [?] Headache disorders\n --CHILD--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a..."
] |
MB4D
|
Headache, not elsewhere classified
|
[
{
"from_icd11": "8A8Z",
"icd10_code": "G43B0",
"icd10_title": "Ophthalmoplegic migraine, not intractable"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G4453",
"icd10_title": "Primary thunderclap headache"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43409",
"icd10_title": "Hemiplegic migraine, not intractable, without status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43A0",
"icd10_title": "Cyclical vomiting, in migraine, not intractable"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43D0",
"icd10_title": "Abdominal migraine, not intractable"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43709",
"icd10_title": "Chronic migraine without aura, not intractable, without status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43A1",
"icd10_title": "Cyclical vomiting, in migraine, intractable"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43509",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, without status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43719",
"icd10_title": "Chronic migraine without aura, intractable, without status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G4459",
"icd10_title": "Other complicated headache syndrome"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43501",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, with status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G4452",
"icd10_title": "New daily persistent headache (NDPH)"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43C0",
"icd10_title": "Periodic headache syndromes in child or adult, not intractable"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43401",
"icd10_title": "Hemiplegic migraine, not intractable, with status migrainosus"
},
{
"from_icd11": "8A8Z",
"icd10_code": "G43419",
"icd10_title": "Hemiplegic migraine, intractable, without status migrainosus"
}
] |
G43B0
|
Ophthalmoplegic migraine, not intractable
|
In March 2018, a 69-year-old woman with a history of follicular thyroid cancer presented with a 3-month history of masses in the left chest. She had undergone total thyroidectomy with right-sided cervical lymphadenectomy in our department and pathological diagnosis was thyroid follicular carcinoma , followed postoperative iodine treatment 10 years previously. Two years later, the patient developed a recurrence of left cervical lymphadenopathy, for which she underwent left-sided modified radical neck dissection. Unfortunately, she experienced left supraclavicular and left axillary lymph node recurrence in 2013 and underwent a third operation to resect these metastatic lesions. Following the third iodine treatment, levothyroxine tablets were administered. Physical examination revealed solid, mobile, painless masses in the left chest wall, the largest of which was approximately 4 × 3.5 cm in size below the left clavicle; a medium-sized mass was found in the second intercostal space that was 2.5 × 2 cm in size, while the smallest mass was in the third intercostal space and measured 1 × 1 cm in size . Ultrasonographic examination revealed hypoechoic lymph nodes. A computed tomography (CT) scan of the chest showed lymph node enlargement in the subclavian area, and no pulmonary metastases were found . Systemic and local scans were performed 48 h after oral administration of iodine-131 5 mCi. There was no significant radioactive concentration in the thyroid region, but there was radioactive concentration under the left clavicle and increased point-like radioactive uptake in the left chest wall. Left subclavian and thoracic lymph node metastases of thyroid carcinoma were considered . Cranial and abdominal CT and whole-body bone scans did not reveal further pathology. Laboratory test results revealed normal T4 and T3 levels, a thyroid-stimulating hormone (TSH) level of 2.5 pg/ml (normal < 10 pg/ml) and serum thyroglobulin (TG) level of 3000 ng/ml (normal < 50 ng/ml). Ultrasound-guided core-needle biopsy of the mass revealed a follicular thyroid neoplasm with lymph node metastases. The results of immunohistochemical analysis indicated TTF, CK7, and thyroglobulin positivity and partial CD56 positivity, while the test for CgA was negative; the Ki67 index was 5%. Mass resection was performed on the left chest wall under local anesthesia. Multiple lymph nodes were found to be enlarged under the left clavicle, and a total of 4 lymph nodes were removed, with a maximum diameter of 3 cm. The second intercostal lymph node was 1.5 cm in diameter, and the diameter of the third intercostal lymph node was 0.6 cm . The final pathological diagnosis was thyroid follicular carcinoma metastasis to the lymph node . Following a I 131 radiotherapy session, TSH suppression therapy was continued. Nearly 1 year after the last operation, the patient’s serum thyroglobulin level has remained below the threshold, and no local recurrence or distant metastasis has been observed. Fig. 1 Tumor tissue infiltration was observed in the local capsule ( a ) and ( b ), and tumor tissue invasion was observed in the capsule vessels( c ) and ( d ). (Original magnification qre 40x in A and C, 200x in B and D) Fig. 2 Masses observed in the left chest wall. The largest one was in the left subclavian area, with a size of 4 × 3.5 cm; the intermediate and smallest masses were located in the second and third intercostal levels and were 2.5 × 2 cm and 1 × 1 cm in size, respectively. Scars from the previous three operations are clearly visible Fig. 3 CT scan showing the shadow of the horizontal cutaneous nodules (red circle) in the left subclavian region ( a ) and the second ( b ) and third ( c ) intercostal spaces of the left anterior chest wall. The largest one is in the left subclavian area, which measured approximately 3 × 3 cm (yellow arrow); the density was uniform, the boundary was clear, the enhancement scan was non-uniform and significantly enhanced, and lymph node metastasis was considered. A B Fig. 4 Systemic and local scans were performed at 48 h after treatment with oral I131 5 mCi. No thyroid development was observed. The left subclavian reflex concentration is considered thyroid cancer metastasis to the left subclavian lymph node Fig. 5 The tumor cells were mildly dysplastic and formed follicular structures of different sizes. Glial secretions were seen in some follicular cavities( a ), Immunohistochemical staining for TTF1( b ), CK7( c ), thyroglobulin( d ) and CD56( e ) were positive. (original magnification, 200x) Fig. 6 A total of 4 lymph nodes were removed from under the left clavicle with a maximum diameter of 3 cm. The second intercostal lymph node was 1.5 cm in diameter; the diameter of the third intercostal lymph node was 0.6 cm, and it was completely removed through the second incision Fig. 7 In the lymph node, dysplastic cells were found to be arranged in a microfollicular or trabecular shape; no papillary structure, no obvious increase in cell volume, and no obvious nuclear pseudoinclusion body were observed (hematoxylin-eosin staining; original magnification, 200x)
| 4.023438
| 0.979492
|
sec[1]/p[0]
|
en
| 0.999997
|
31747942
|
https://doi.org/10.1186/s13000-019-0907-0
|
[
"lymph",
"node",
"thyroid",
"intercostal",
"chest",
"subclavian",
"follicular",
"diameter",
"wall",
"local"
] |
[
{
"code": "BD9Z",
"title": "Disorders of lymphatic vessels or lymph nodes, unspecified"
},
{
"code": "BD90.Z",
"title": "Lymphadenitis, unspecified"
},
{
"code": "BD90.Y",
"title": "Other specified lymphadenitis"
},
{
"code": "BD9Y",
"title": "Other specified disorders of lymphatic vessels or lymph nodes"
},
{
"code": "MA01.Z",
"title": "Enlarged lymph nodes, unspecified"
},
{
"code": "FA20.0",
"title": "Seropositive rheumatoid arthritis"
},
{
"code": "MF30",
"title": "Breast lump or mass female"
},
{
"code": "BB40",
"title": "Acute or subacute infectious endocarditis"
},
{
"code": "FA0Z",
"title": "Osteoarthritis, unspecified"
},
{
"code": "FA85.10",
"title": "Localised central endplate defect"
}
] |
=== ICD-11 CODES FOUND ===
[BD9Z] Disorders of lymphatic vessels or lymph nodes, unspecified
Also known as: Disorders of lymphatic vessels or lymph nodes, unspecified | Lymphatic system disorders | lymph disease NOS | lymph gland disease | Lymphatic system disease NOS
[BD90.Z] Lymphadenitis, unspecified
Also known as: Lymphadenitis, unspecified | Lymphadenitis | adenitis NOS | inflammation of gland | lymphatic gland inflammation
[BD90.Y] Other specified lymphadenitis
Also known as: Other specified lymphadenitis | Dermatopathic lymphadenopathy | lipomelanotic reticulosis | Infective inguinal bubo | bubo
[BD9Y] Other specified disorders of lymphatic vessels or lymph nodes
Also known as: Other specified disorders of lymphatic vessels or lymph nodes | Chylous cyst | Mesentery chylous cyst | Peritoneum chylous cyst | Lymphocele
[MA01.Z] Enlarged lymph nodes, unspecified
Also known as: Enlarged lymph nodes, unspecified | Enlarged lymph nodes | swollen glands | Lymphadenopathy | adenopathy
[FA20.0] Seropositive rheumatoid arthritis
Also known as: Seropositive rheumatoid arthritis | high positive rheumatoid factor | low positive rheumatoid factor | high positive anticitrullinated protein antibody | low positive anticitrullinated protein antibody
[MF30] Breast lump or mass female
Also known as: Breast lump or mass female | breast irregular nodularity | breast node | lump in breast | lump or mass in breast NOS
[BB40] Acute or subacute infectious endocarditis
Also known as: Acute or subacute infectious endocarditis | subacute infective endocarditis NOS | infective endocarditis NOS | acute infective endocarditis NOS | infectious endocarditis
Excludes: Infectious myocarditis
[FA0Z] Osteoarthritis, unspecified
Also known as: Osteoarthritis, unspecified | osteoarthritis NOS | arthrosis NOS | OA - [osteoarthritis] | Osteoarthritis with determinants
[FA85.10] Localised central endplate defect
Also known as: Localised central endplate defect | Schmorl nodes | schmorl's nodes | schmorl's nodules
=== GRAPH WALKS ===
--- Walk 1 ---
[BD9Z] Disorders of lymphatic vessels or lymph nodes, unspecified
--PARENT--> [?] Disorders of lymphatic vessels or lymph nodes
Def: Disorders due to developmental and acquired disturbances of lymph circulation and drainage and to infective disorders of lymph vessels and nodes....
--CHILD--> [BD90] Lymphadenitis
--- Walk 2 ---
[BD9Z] Disorders of lymphatic vessels or lymph nodes, unspecified
--PARENT--> [?] Disorders of lymphatic vessels or lymph nodes
Def: Disorders due to developmental and acquired disturbances of lymph circulation and drainage and to infective disorders of lymph vessels and nodes....
--CHILD--> [BD92] Lymphangiectasia
--- Walk 3 ---
[BD90.Z] Lymphadenitis, unspecified
--PARENT--> [BD90] Lymphadenitis
--CHILD--> [BD90.2] Chronic lymphadenitis
--- Walk 4 ---
[BD90.Z] Lymphadenitis, unspecified
--PARENT--> [BD90] Lymphadenitis
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--- Walk 5 ---
[BD90.Y] Other specified lymphadenitis
--PARENT--> [BD90] Lymphadenitis
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
--- Walk 6 ---
[BD90.Y] Other specified lymphadenitis
--PARENT--> [BD90] Lymphadenitis
--EXCLUDES--> [?] Enlarged lymph nodes
Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....
|
[
"[BD9Z] Disorders of lymphatic vessels or lymph nodes, unspecified\n --PARENT--> [?] Disorders of lymphatic vessels or lymph nodes\n Def: Disorders due to developmental and acquired disturbances of lymph circulation and drainage and to infective disorders of lymph vessels and nodes....\n --CHILD--> [BD90] Lymphadenitis",
"[BD9Z] Disorders of lymphatic vessels or lymph nodes, unspecified\n --PARENT--> [?] Disorders of lymphatic vessels or lymph nodes\n Def: Disorders due to developmental and acquired disturbances of lymph circulation and drainage and to infective disorders of lymph vessels and nodes....\n --CHILD--> [BD92] Lymphangiectasia",
"[BD90.Z] Lymphadenitis, unspecified\n --PARENT--> [BD90] Lymphadenitis\n --CHILD--> [BD90.2] Chronic lymphadenitis",
"[BD90.Z] Lymphadenitis, unspecified\n --PARENT--> [BD90] Lymphadenitis\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....",
"[BD90.Y] Other specified lymphadenitis\n --PARENT--> [BD90] Lymphadenitis\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes....",
"[BD90.Y] Other specified lymphadenitis\n --PARENT--> [BD90] Lymphadenitis\n --EXCLUDES--> [?] Enlarged lymph nodes\n Def: Enlarged lymph node is called lymphadenopathy which means the abnormal enlargement of lymph nodes...."
] |
BD9Z
|
Disorders of lymphatic vessels or lymph nodes, unspecified
|
[
{
"from_icd11": "BD9Z",
"icd10_code": "I898",
"icd10_title": "Other specified noninfective disorders of lymphatic vessels and lymph nodes"
},
{
"from_icd11": "BD9Z",
"icd10_code": "I899",
"icd10_title": "Noninfective disorder of lymphatic vessels and lymph nodes, unspecified"
},
{
"from_icd11": "BD9Z",
"icd10_code": "I89",
"icd10_title": "Other noninfective disorders of lymphatic vessels and lymph nodes"
},
{
"from_icd11": "BD90.Z",
"icd10_code": "I889",
"icd10_title": "Nonspecific lymphadenitis, unspecified"
},
{
"from_icd11": "BD90.Z",
"icd10_code": "I88",
"icd10_title": "Nonspecific lymphadenitis"
},
{
"from_icd11": "BD90.Z",
"icd10_code": "I888",
"icd10_title": "Other nonspecific lymphadenitis"
},
{
"from_icd11": "BD90.Z",
"icd10_code": "L00-L08",
"icd10_title": ""
},
{
"from_icd11": "MA01.Z",
"icd10_code": "R599",
"icd10_title": "Enlarged lymph nodes, unspecified"
},
{
"from_icd11": "MA01.Z",
"icd10_code": "R59",
"icd10_title": "Enlarged lymph nodes"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0569",
"icd10_title": "Rheumatoid arthritis of multiple sites with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0579",
"icd10_title": "Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M05612",
"icd10_title": "Rheumatoid arthritis of left shoulder with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0570",
"icd10_title": "Rheumatoid arthritis with rheumatoid factor of unspecified site without organ or systems involvement"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0560",
"icd10_title": "Rheumatoid arthritis of unspecified site with involvement of other organs and systems"
},
{
"from_icd11": "FA20.0",
"icd10_code": "M0500",
"icd10_title": "Felty's syndrome, unspecified site"
}
] |
I898
|
Other specified noninfective disorders of lymphatic vessels and lymph nodes
|
A 37-year-old woman with moderate myopia presented with complaints of blurred vision and photopsia in her right eye for 1 week. She had no antecedent flu-like illness. The patient’s medical and family histories were unremarkable. Best-corrected visual acuity (BCVA) with a Japanese standard Landolt visual acuity chart was 0.09 OD and 1.2 OS. Left eye showed normal appearance. Slit lamp examination showed 2+ cells in the anterior vitreous OD. Funduscopic examination showed foveal granularity and multiple white dots extending from the posterior pole to the retinal midperiphery. Some white dots in the temporal fovea were relatively large . Fluorescein angiography (FA) showed hyperfluorescent spots from the initial phase, corresponding to the white dots, and the staining of retinal veins and the optic disc in the late phase. ICGA was normal in the early phase, but in the late phase numerous hypofluorescent spots were scattered over a wider area with and without white dots . Goldmann perimetry showed a blind spot enlargement and a small central scotoma OD. Additionally, EDI-OCT showed hyper-reflective lesions in the ganglion cell layer (GCL) , the loss of photoreceptor inner segment/outer segment junction (IS/OS) line, detachment between the RPE and Bruch’s membrane, moderately reflective, dome-shaped focal lesions within the photoreceptor layer , and locally thickened choroid compared with neighboring areas, corresponding to the large white dots in the temporal fovea and inferotemporal perifovea with pigment epithelium detachment. Multiple ruptures of the RPE and Bruch’s membrane were apparently observed in the temporal lesion , whereas Bruch’s membrane underlying the damaged RPE was found to be continuous in the inferotemporal lesion . Choroidal thickness at the fovea and the adjacent temporal lesion was 243 and 330 μm OD, respectively . The patient received a diagnosis of MEWDS OD. Figure 1 Photographs of the right eye in a patient with multiple evanescent white dot syndrome at the initial visit (A-C) and 3 months later (D). A , Multiple white dots (white arrows) with foveal granularity extending from the posterior pole to the midperiphery were seen. Relatively large white dots were also observed in the temporal fovea (yellow arrows). B , Late-phase fluorescein angiography showing hyperfluorescence corresponding to white dots (white and yellow arrows), retinal vasculitis (black arrows), and optic disc staining. C , Late–phase indocyanine green angiography images showing multiple hypofluorescent spots scattered over a wider area than the white dots (white and yellow arrows). D , White dots spontaneously disappeared, but large white dots (yellow arrows) in the temporal fovea developed scars. Figure 2 Horizontal enhanced depth imaging optical coherence tomography (EDI-OCT) images across the fovea of the right eye. Right panels are magnified views of the area indicated in the left panels. A , At the initial visit, ganglion cell layer (GCL) hyper-reflectivity (black arrowheads), photoreceptor inner segment/outer segment junction boundary loss, detachment between the retinal pigment epithelium (RPE) and Bruch’s membrane, moderately reflective, dome-shaped focal lesions (white arrowheads) in the photoreceptor layer were present and corresponded to the large white dot at the temporal fovea. The site with pigment epithelium detachment involved the RPE/Bruch’s membrane ruptures (red and yellow arrowheads). Choroidal thickness at the fovea and the adjacent temporal lesion was 243 and 330 μm, respectively. B , One month later, the pigment epithelium detachment and abnormal GCL hyper-reflectivity spontaneously resolved. Focal lesions in the photoreceptor layer also markedly decreased. However, this region developed a conforming-type focal choroidal excavation (FCE) and the choroidal thickness at the fovea and the FCE lesion decreased to 210 and 140 μm, respectively. An abnormal hyper-reflective lesion also appeared within the choroid beneath the FCE (arrow). C , Three months after the initial visit, focal lesions in the photoreceptor layer almost resolved, but cystoid changes in the inner retinal layers and marked outer layer thinning occurred. The abnormal hyper-reflective lesion (yellow arrows) in the region of the scar within the choroid increased in size compared to that at 1 month . The subfoveal choroidal thickness further decreased to 181 μm. Figure 3 EDI-OCT images through a white dot at the inferotemporal side of the fovea. A , At the initial visit, the white dot involved inner and outer retinal morphological abnormalities including pigment epithelium detachment and moderately reflective focal lesions (white arrowheads) within photoreceptor layer as well as the other white dot at the temporal fovea . However, there was no apparent rupture of Bruch’s membrane (yellow arrowheads) underlying the damaged RPE (red arrowheads). B , Three months later, the lesion showed the resolution of the pigment epithelium detachment and the appearance of an abnormal hyper-reflective lesion within the choroid (arrows), but no apparent sign of FCE development.
| 4.160156
| 0.951172
|
sec[1]/p[0]
|
en
| 0.999999
|
25410093
|
https://doi.org/10.1186/1471-2415-14-135
|
[
"white",
"dots",
"fovea",
"temporal",
"lesion",
"layer",
"arrows",
"reflective",
"photoreceptor",
"detachment"
] |
[
{
"code": "EF5Y",
"title": "Other specified dermatoses attributable to hyperviscosity or microvascular occlusion"
},
{
"code": "JB41.1",
"title": "Deep phlebothrombosis in the puerperium"
},
{
"code": "EB60.Y",
"title": "Lichen sclerosus of other specified sites"
},
{
"code": "MC80.00",
"title": "White coat hypertension"
},
{
"code": "1F2D.2",
"title": "White piedra"
},
{
"code": "LA12.1",
"title": "Congenital cataract"
},
{
"code": "9B65.0",
"title": "Noninfectious posterior uveitis"
},
{
"code": "9B71.1&XS00",
"title": "Hypertensive Retinopathy, Stage 3, Haemorrhage, blot, dot, or flame-shaped, microaneurysm, cotton-wool spot, hard exudate, or combination of these signs"
},
{
"code": "LA13.3",
"title": "Congenital vitreoretinal dysplasia"
},
{
"code": "4A44.2",
"title": "Giant cell arteritis"
}
] |
=== ICD-11 CODES FOUND ===
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
Also known as: Other specified dermatoses attributable to hyperviscosity or microvascular occlusion | Cutaneous microvascular occlusion by platelet plugs | Cutaneous microvascular disturbances due to myeloproliferative disorder-associated platelet plugs | Cutaneous microvascular disturbances due to paroxysmal nocturnal haemoglobinuria-associated platelet plugs | Cutaneous microvascular occlusion by emboli
[JB41.1] Deep phlebothrombosis in the puerperium
Also known as: Deep phlebothrombosis in the puerperium | postnatal deep vein thrombosis | postpartum deep phlebothrombosis | postpartum deep-vein thrombosis | DVT - [deep venous thrombosis] postnatal
[EB60.Y] Lichen sclerosus of other specified sites
Also known as: Lichen sclerosus of other specified sites | Extragenital lichen sclerosus | Guttate lichen sclerosus | White spot disease | Guttate scleroderma
[MC80.00] White coat hypertension
Definition: Persistently elevated office blood pressure readings with persistently normal out-of-the-office readings.
Also known as: White coat hypertension | white coat syndrome
[1F2D.2] White piedra
Definition: A disease of the hair shaft, caused by an infection with the fungi Trichosporon beigelii. This disease is characterised by irregular, soft, white, or light brown nodules which adhere to the hair follicle. Transmission is by direct contact with contaminated soil or water, or by airborne transmission. Confirmation is by identification of Trichosporon beigelii in a hair follicle sample.
Also known as: White piedra | Trichosporosis nodosa
Includes: Trichosporosis nodosa
[LA12.1] Congenital cataract
Definition: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness; typically diagnosed at birth
Also known as: Congenital cataract | congenita cataracta | congenital cortical cataract | crystalline cataract | Volkmann-type congenital cataract
[9B65.0] Noninfectious posterior uveitis
Also known as: Noninfectious posterior uveitis | noninfectious choroiditis | Posterior uveitis due to Vogt Koyanagi Harada syndrome | Sympathetic Ophthalmia | sympathetic ophthalmitis
[LA13.3] Congenital vitreoretinal dysplasia
Definition: Any disease caused by the maldevelopment of the vitreous and retina.
Also known as: Congenital vitreoretinal dysplasia | Familial exudative vitreoretinopathy | Criswick-Schepens syndrome | FEVR - [familial exudative vitreoretinopathy] | Teratogenic congenital retinal dysplasia
[4A44.2] Giant cell arteritis
Definition: Arteritis, often granulomatous, usually affecting the aorta and/or its major branches, with a predilection for the branches of the carotid artery. Often involves the temporal artery. Onset usually in patients older than 50 and often associated with polymyalgia rheumatica.
Also known as: Giant cell arteritis | GCA - [giant cell arteritis] | temporal arteritis | cranial arteritis | Horton disease
=== GRAPH WALKS ===
--- Walk 1 ---
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
--PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion
Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....
--CHILD--> [EF50] Livedoid vasculopathy
--- Walk 2 ---
[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
--PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion
Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....
--RELATED_TO--> [?] Thrombotic thrombocytopenic purpura
Def: This condition is idiopathic. This condition is characterised by abnormality of blood coagulation causing extensive microscopic clots to form in the small blood vessels throughout the body resulting i...
--- Walk 3 ---
[JB41.1] Deep phlebothrombosis in the puerperium
--PARENT--> [JB41] Venous complications in the puerperium
--EXCLUDES--> [?] Venous complications in pregnancy
--- Walk 4 ---
[JB41.1] Deep phlebothrombosis in the puerperium
--PARENT--> [JB41] Venous complications in the puerperium
--EXCLUDES--> [?] Venous complications in pregnancy
--- Walk 5 ---
[EB60.Y] Lichen sclerosus of other specified sites
--PARENT--> [EB60] Lichen sclerosus
Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...
--CHILD--> [EB60.1] Lichen sclerosus of penis
Def: Lichen sclerosus of the penis develops almost exclusively in uncircumcised males and is the result of chronic occluded contact of susceptible epithelium to urine. It often causes dyspareunia and diffi...
--- Walk 6 ---
[EB60.Y] Lichen sclerosus of other specified sites
--PARENT--> [EB60] Lichen sclerosus
Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...
--CHILD--> [EB60.Y] Lichen sclerosus of other specified sites
|
[
"[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion\n --PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion\n Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....\n --CHILD--> [EF50] Livedoid vasculopathy",
"[EF5Y] Other specified dermatoses attributable to hyperviscosity or microvascular occlusion\n --PARENT--> [?] Dermatoses attributable to hyperviscosity or microvascular occlusion\n Def: A range of disorders characterised by vascular occlusion but attributable not to primary vascular inflammation but to intravascular occlusion....\n --RELATED_TO--> [?] Thrombotic thrombocytopenic purpura\n Def: This condition is idiopathic. This condition is characterised by abnormality of blood coagulation causing extensive microscopic clots to form in the small blood vessels throughout the body resulting i...",
"[JB41.1] Deep phlebothrombosis in the puerperium\n --PARENT--> [JB41] Venous complications in the puerperium\n --EXCLUDES--> [?] Venous complications in pregnancy",
"[JB41.1] Deep phlebothrombosis in the puerperium\n --PARENT--> [JB41] Venous complications in the puerperium\n --EXCLUDES--> [?] Venous complications in pregnancy",
"[EB60.Y] Lichen sclerosus of other specified sites\n --PARENT--> [EB60] Lichen sclerosus\n Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...\n --CHILD--> [EB60.1] Lichen sclerosus of penis\n Def: Lichen sclerosus of the penis develops almost exclusively in uncircumcised males and is the result of chronic occluded contact of susceptible epithelium to urine. It often causes dyspareunia and diffi...",
"[EB60.Y] Lichen sclerosus of other specified sites\n --PARENT--> [EB60] Lichen sclerosus\n Def: Lichen sclerosus is a chronic inflammatory dermatosis of unknown aetiology. It affects both women and men of all ages. It is characterised by the development of white, smooth, atrophic plaques on vulv...\n --CHILD--> [EB60.Y] Lichen sclerosus of other specified sites"
] |
EF5Y
|
Other specified dermatoses attributable to hyperviscosity or microvascular occlusion
|
[
{
"from_icd11": "JB41.1",
"icd10_code": "O871",
"icd10_title": "Deep phlebothrombosis in the puerperium"
},
{
"from_icd11": "1F2D.2",
"icd10_code": "B362",
"icd10_title": "White piedra"
},
{
"from_icd11": "LA12.1",
"icd10_code": "Q120",
"icd10_title": "Congenital cataract"
},
{
"from_icd11": "LA13.3",
"icd10_code": "Q141",
"icd10_title": "Congenital malformation of retina"
},
{
"from_icd11": "4A44.2",
"icd10_code": "M316",
"icd10_title": "Other giant cell arteritis"
}
] |
O871
|
Deep phlebothrombosis in the puerperium
|
A 28-year-old unmarried woman with regular menstruation reported vaginal bleeding 1 week after her last menstrual cycle. The initial serum hCG level was 44,681 mIU/mL during the first examination performed at another hospital. Color Doppler ultrasound revealed a teratoma approximately 3.8 × 3.4 cm 2 in size in the right adnexa area. A hypoechoic mass, 3.1 × 2.1 cm 2 in size, was observed in the left adnexal area, along with a strong adjacent echo, 1.5 × 1.3 cm 2 in size. The lesion in the left adnexal region was speculated as ectopic pregnancy. The patient had no abdominal pain or other discomfort and was recommended to be hospitalized for surgical intervention. She declined the diagnosis of ectopic pregnancy based on strict contraceptive measures and approached the Reproductive Department of our hospital for further diagnosis and treatment. Ultrasound examination detected a teratoma sized 3.7 × 3.5 × 3.8 cm 3 in the right ovary. A slightly strong echo, approximately 1.5 × 1.6 × 1.5 cm 3 in size, was observed in the left ovary, with a distinct boundary and no blood flow signal detected. Another heterogeneous echogenic mass was detected in the left adnexal area, approximately 3.9 × 4.2 × 5.2 cm 3 in size, along with an unclear boundary between the mass and ovary and abundant blood flow signals . The slightly strong echo on the left ovary was speculated to be an ovarian teratoma. A heterogeneous echogenic mass in the left adnexal area was considered ovarian pregnancy. The patient exhibited elevated levels of serum hCG (137,822.2 mIU/mL) and carbohydrate antigen 19-9 (CA 19-9) (102.6 U/mL; normal reference value < 30.9 U/mL), along with other tumor markers, such as cancer antigen 125 (CA-125), alpha-fetoprotein, carcinoembryonic antigen, and neuron-specific enolase, which were within the normal range. Given the rarity of clinical features, we invited experts in gynecological oncology, gynecological radiochemotherapy, and medical imaging to discuss this case, supplemented with unenhanced and enhanced multidetector computed tomography images of the head, chest, abdomen, and pelvis. No other lesions were detected. To obtain histological evidence, the patient consented to undergo laparoscopic surgery. No ascites were detected during surgery, and no abnormalities were identified in the uterus, omentum, intestine, diaphragm, liver, or peritoneum. A mass, approximately 6 cm in diameter, was observed in the left ovary, presented as a nodular, uneven, and kermesinus protrusion with dilated blood vessels on the surface . The tumor exhibited a soft and fragile texture, and sections were kermesinus and spongy, with evident bleeding and necrosis . Furthermore, the right ovary presented a cyst approximately 4 cm in diameter, smooth in appearance and containing hair and fat. The ovarian tumors were resected, placed in specimen bags, and extracted via the trocar port in the abdomen. Rapid freezing pathological examination revealed the following: <left ovarian tumor> a large number of dysplastic trophoblasts with hemorrhage and necrosis and no precise placental villi were observed; <right ovarian cyst> mature cystic teratoma. On the second day postsurgery, the patient presented reduced hCG and CA 19-9 levels (46,252.8 mIU/mL and 78.1 U/mL, respectively). The final pathology findings postsurgery were as follows: <left ovarian tumor> mixed germ cell neoplasms: choriocarcinoma mixed with mature teratoma; <right ovarian cyst> mature teratoma. The Department of Gynecological Oncology and Chemoradiotherapy, along with clinical pharmacists, worked to develop a suitable chemotherapy regimen for this patient: 15, 30, and 15 mg bleomycin on days 1, 4, and 15; 100 mg etoposide on days 1 to 5; 30, 20, 20, 20, and 20 mg cisplatin on days 1 to 5. Goserelin acetate was used to protect ovarian function. The patient developed adverse reactions, such as grade IV bone marrow suppression, oral ulcers, and hair loss, after the first chemotherapy cycle. One month later, serum hCG and CA19-9 levels decreased to normal levels . Subsequently, a laparoscopic fertility-preserving comprehensive staging surgery was performed: left salpingo-oophorectomy, pelvic lymph node dissection, omentectomy, and appendectomy. Histological examination of specimens from the second surgery, including 31 pelvic lymph nodes, showed no malignant tumor involvement. In addition, the pelvic–abdominal cavity washing fluid was negative, with several mature teratoma components detected in the left ovary. The final diagnosis was stage IA mixed germ cell tumor of the left ovary (nongestational choriocarcinoma of the ovary mixed with mature teratoma). The patient completed 2 cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy after comprehensive staging surgery and experienced no significant change in body weight during the 6 months of treatment. She was followed up every 3 months for 2 years postsurgery. Menstruation resumed 4 months after completing the last chemotherapy cycle, and tumor indicators were within the normal range. No signs of recurrence were observed after the 36-month follow-up.
| 3.990234
| 0.977051
|
sec[1]/p[0]
|
en
| 0.999997
|
PMC11062740
|
https://doi.org/10.1097/MD.0000000000036996
|
[
"ovary",
"teratoma",
"ovarian",
"tumor",
"approximately",
"mature",
"area",
"adnexal",
"along",
"mixed"
] |
[
{
"code": "GA1Z&XA1QK0",
"title": "Noninflammatory disorders of ovary"
},
{
"code": "GA07.Z&XA1QK0",
"title": "Inflammation of ovary"
},
{
"code": "GA30.6",
"title": "Premature ovarian failure"
},
{
"code": "JA01.2",
"title": "Ovarian pregnancy"
},
{
"code": "QF01.10",
"title": "Acquired absence of female genital organs"
},
{
"code": "2F32.0",
"title": "Cystic teratoma"
},
{
"code": "2F00.Y",
"title": "Other specified benign neoplasm of middle ear or respiratory system"
},
{
"code": "2A00.1Y",
"title": "Other specified embryonal tumours of brain"
},
{
"code": "2F32.Y",
"title": "Other specified benign neoplasm of ovary"
},
{
"code": "2C80.2",
"title": "Germ cell tumour of testis"
}
] |
=== ICD-11 CODES FOUND ===
[GA30.6] Premature ovarian failure
Definition: Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conceiving and delivering a pregnancy. POF/POI occurs mostly without a known cause, but can be caused by the following conditions: numerical and structural chromosomal abnormalities, Fragile X (FMR1) premutations, autoimmune disorders, radiation therapy, chemotherapy, galactosemia, and other rare enzyme
Also known as: Premature ovarian failure | female hypergonadotropic hypogonadism | hypergonadotrophic ovarian failure | primary female hypogonadism | POF - [premature ovarian failure]
Excludes: Isolated gonadotropin deficiency | Postprocedural ovarian failure
[JA01.2] Ovarian pregnancy
Definition: A condition characterised by implantation of the embryo within the ovary during pregnancy.
Also known as: Ovarian pregnancy
[QF01.10] Acquired absence of female genital organs
Also known as: Acquired absence of female genital organs | Acquired absence of cervix | amputation of cervix | Acquired absence of the uterus | acquired uterine absence
[2F32.0] Cystic teratoma
Definition: A condition of the ovary, caused by abnormal proliferation due to genetic mutations, abnormal growth or division of germ cells. This condition is characterised by a benign ovarian neoplasm, and abdominal pain, mass or swelling, or abnormal uterine bleeding, and may lead to ovarian torsion or cystic rupture. Confirmation is by imaging.
Also known as: Cystic teratoma
[2F00.Y] Other specified benign neoplasm of middle ear or respiratory system
Also known as: Other specified benign neoplasm of middle ear or respiratory system | Benign neoplasm of middle ear, nasal cavity or accessory sinuses | Transphenoidal adenoma | Benign neoplasm of accessory sinus | Benign neoplasm of cartilage of nose
[2A00.1Y] Other specified embryonal tumours of brain
Also known as: Other specified embryonal tumours of brain | Atypical teratoid rhabdoid tumour of brain | Choriocarcinoma of the central nervous system | Germinoma of the central nervous system | germinoma of unspecified site
[2F32.Y] Other specified benign neoplasm of ovary
Also known as: Other specified benign neoplasm of ovary | Serous or mucinous ovarian cystadenoma of childhood | Benign androblastoma of ovary | tubular androblastoma of unspecified site, female | Adenofibroma of ovary
[2C80.2] Germ cell tumour of testis
Definition: A germ cell tumour arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumour.
Also known as: Germ cell tumour of testis | Choriocarcinoma of testis | choriocarcinoma of unspecified site, male | chorionic carcinoma of unspecified site, male | Malignant trophoblastic tumour of testis
=== GRAPH WALKS ===
--- Walk 1 ---
[GA30.6] Premature ovarian failure
Def: Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conce...
--EXCLUDES--> [?] Postprocedural ovarian failure
Def: A condition in women characterised by amenorrhea, caused by or subsequent to any intervention. This condition may also present with hot flashes, night sweats, irritability, poor concentration, decreas...
--PARENT--> [?] Menopausal or perimenopausal disorders
Def: Any disorder affecting females, characterised by pathological changes during the menopausal and perimenopausal periods....
--- Walk 2 ---
[GA30.6] Premature ovarian failure
Def: Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conce...
--RELATED_TO--> [?] Secondary amenorrhoea
Def: In women who have menstruated previously, no menses for an interval of time equivalent to a total of at least 3 previous cycles, or 6 months...
--PARENT--> [?] Amenorrhoea
Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...
--- Walk 3 ---
[JA01.2] Ovarian pregnancy
Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....
--PARENT--> [JA01] Ectopic pregnancy
Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....
--CHILD--> [JA01.1] Tubal pregnancy
Def: A condition characterised by implantation of the embryo within the fallopian tube (ampullary, isthmus, interstitium) during pregnancy....
--- Walk 4 ---
[JA01.2] Ovarian pregnancy
Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....
--PARENT--> [JA01] Ectopic pregnancy
Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....
--CHILD--> [JA01.2] Ovarian pregnancy
Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....
--- Walk 5 ---
[QF01.10] Acquired absence of female genital organs
--RELATED_TO--> [?] Traumatic amputation of part of vulva
--PARENT--> [?] Acquired absence of female genital organs
--- Walk 6 ---
[QF01.10] Acquired absence of female genital organs
--RELATED_TO--> [?] Traumatic amputation of entire vulva
--EXCLUDES--> [?] Female Genital Mutilation
Def: A condition caused by procedures or other interventions for non-medical purposes. This condition is characterised by the partial or total removal of the external female genitalia or other injury to th...
|
[
"[GA30.6] Premature ovarian failure\n Def: Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conce...\n --EXCLUDES--> [?] Postprocedural ovarian failure\n Def: A condition in women characterised by amenorrhea, caused by or subsequent to any intervention. This condition may also present with hot flashes, night sweats, irritability, poor concentration, decreas...\n --PARENT--> [?] Menopausal or perimenopausal disorders\n Def: Any disorder affecting females, characterised by pathological changes during the menopausal and perimenopausal periods....",
"[GA30.6] Premature ovarian failure\n Def: Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conce...\n --RELATED_TO--> [?] Secondary amenorrhoea\n Def: In women who have menstruated previously, no menses for an interval of time equivalent to a total of at least 3 previous cycles, or 6 months...\n --PARENT--> [?] Amenorrhoea\n Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...",
"[JA01.2] Ovarian pregnancy\n Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....\n --PARENT--> [JA01] Ectopic pregnancy\n Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....\n --CHILD--> [JA01.1] Tubal pregnancy\n Def: A condition characterised by implantation of the embryo within the fallopian tube (ampullary, isthmus, interstitium) during pregnancy....",
"[JA01.2] Ovarian pregnancy\n Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....\n --PARENT--> [JA01] Ectopic pregnancy\n Def: Any condition characterised by implantation of the embryo outside the endometrium and endometrial cavity during pregnancy....\n --CHILD--> [JA01.2] Ovarian pregnancy\n Def: A condition characterised by implantation of the embryo within the ovary during pregnancy....",
"[QF01.10] Acquired absence of female genital organs\n --RELATED_TO--> [?] Traumatic amputation of part of vulva\n --PARENT--> [?] Acquired absence of female genital organs",
"[QF01.10] Acquired absence of female genital organs\n --RELATED_TO--> [?] Traumatic amputation of entire vulva\n --EXCLUDES--> [?] Female Genital Mutilation\n Def: A condition caused by procedures or other interventions for non-medical purposes. This condition is characterised by the partial or total removal of the external female genitalia or other injury to th..."
] |
GA1Z&XA1QK0
|
Noninflammatory disorders of ovary
|
[
{
"from_icd11": "GA30.6",
"icd10_code": "E2839",
"icd10_title": "Other primary ovarian failure"
},
{
"from_icd11": "GA30.6",
"icd10_code": "E28319",
"icd10_title": "Asymptomatic premature menopause"
},
{
"from_icd11": "GA30.6",
"icd10_code": "E28310",
"icd10_title": "Symptomatic premature menopause"
},
{
"from_icd11": "GA30.6",
"icd10_code": "E283",
"icd10_title": "Primary ovarian failure"
},
{
"from_icd11": "JA01.2",
"icd10_code": "O00201",
"icd10_title": "Right ovarian pregnancy without intrauterine pregnancy"
},
{
"from_icd11": "JA01.2",
"icd10_code": "O002",
"icd10_title": "Ovarian pregnancy"
}
] |
E2839
|
Other primary ovarian failure
|
Laboratory data showed that the patient’s white blood cell count, haemoglobin level and platelet count were normal. C-reactive protein and lactate dehydrogenase (LDH) levels were elevated at 151.00 mg/L (normal range: 0~8 mg/L) and 395.00 U/L (0~247 U/L). Tumour markers, such as CEA, NSE, SCCA, ProGRP and CYFRA21-1, were all in the normal range. HIV serology was also negative. Computed tomography (CT) of the chest showed bilateral cavitating lesions with mediastinal enlarged lymph nodes . The patient was started on empiric antibiotic treatment with cefoperazone-sulbactam. After 3 days of therapy, his temperature was still above 38.5 °C. A CT-guided biopsy of the pulmonary cavity was performed on the 4th day after admission. Pathology revealed mild atypical alveolar epithelioid cells and chronic interstitial fibrous tissue proliferation with necrosis. The tissue was negative on smear and culture for acid-fast bacilli. Periodic Acid-Schiff (PAS) stain was also negative. The patient’s antibiotics were changed to imipenem-cilastin sodium and metronidazole. However, the second combination of antibiotics was ineffective. The patient was still febrile, and further blood cultures remained negative. On the fifth day, he underwent bronchoscopy and bronchoalveolar lavage, which were negative for any masses, abscesses or areas of bleeding. However, the patient tested positive for galactomannan antigenemia in bronchoalveolar lavage fluid (BALF) and blood. Aspergillus fumigatus complex was identified from the BALF culture on the 10th day. Due to the new microbiological findings, the patient was treated with voriconazole. In addition, the patient was still treated with linezolid, moxifloxacin and imipenem-cilastin sodium combined with metronidazole successively during the third round of antibiotic use. He was persistently febrile and developed breathing difficulties. We recommended the patient undergo positron emission tomography/computed tomography (PET-CT) to assess the possibility of haematological malignancies. It was refused because of the financial burden. We performed bone marrow aspiration on the 20th day. No abnormal cells were observed in the bone marrow examination. A CT scan performed 23rd day revealed further expanding consolidation and bilateral pleural effusion . Thoracentesis was performed on the 24th day. Pleural fluid analysis revealed a red blood cell count of 16,320 cells/μL and a nucleated cell count of 1280 cells/μL (31% lymphocytes and 54% segmented cells), and the Rivalta test was negative. LDH and adenosine deaminase (ADA) levels were 381.00 U/L (0~247 U/L) and 15.00 U/L, respectively. There were no malignant cells in the pleural effusion. Considering the possibility of opportunistic pathogens, additional drugs were added to cover nocardia and pneumocystic infections. However, his temperature still increased to 40 °C. A second CT-guided biopsy was performed on 27th day to find the cause of repeated fever, and the pathological examination of the specimen revealed polygonal atypical lymphoid cell proliferation with necrosis. The second PAS staining and tissue culture were also negative. Immunohistochemical staining on 35th day showed positive markers for CD20, EBER, BCL-2, PAX5, MUM-1 and a Ki-67 rate of 70% , which was consistent with a diagnosis of diffuse large B-cell lymphoma (DLBCL). He also had a serum IgM test for Epstein–Barr virus (EBV) and other viruses, including influenza and toxoplasma, rubella virus, cytomegalovirus, herpes virus (TORCH), which were all negative. The EBV load was less than 5*10 3 (< 5*10 3 ). He was therefore diagnosed with synchronous pulmonary aspergillosis and DLBCL. Despite the combined R-COPE chemotherapy (rituximab 600 mg d 0 + cyclophosphamide 0.4 g d1–2 + vindesine 4 mg d1 + dexamethasone 20 mg d1–4 + VP-16 0.1 g d1–2) starting 38th days after hospitalization, the patient’s situation continued to deteriorate. He developed cervical, axillary and inguinal lymph node enlargement, which were unremarkable on admission. His LDH increased to 1627 U/L. The following CT scan showed bilateral pleural effusion, atelectasis and consolidations of all right lung lobes with air bronchograms. Then, the patient died of progressive respiratory failure on the 52nd day. Fig. 1 Chest CT findings during hospitalization. a - c : A CT scan of the chest (on admission) showing multiple nodules (thick arrows) and thick-walled cavities (black triangle) in lung fields as well as enlarged mediastinal lymph nodes. d - f : Subsequent chest CT (23rd day) showing new emerging round opacities (thick arrows), expending lung abscess and cavities (black stars), bilateral pleural effusion (thin arrows). g - i : Subsequent chest CT (49th day) showing increased pleural effusion, atelectasis and consolidations on both sides with air bronchograms (white star) Fig. 2 Pathological staining and immunohistochemical results. a - b : Coagulative necrosis and polygonal atypical lymphoid cell proliferation. Immunohistochemical staining shows positive markers for EBER ( c , 400×) and CD20 ( d , 400×) with a Ki-67 rate of 70% ( e , 400×)
| 3.966797
| 0.974121
|
sec[0]/sec[0]/p[2]
|
en
| 0.999999
|
31906982
|
https://doi.org/10.1186/s12885-019-6471-x
|
[
"cell",
"cells",
"pleural",
"chest",
"effusion",
"blood",
"count",
"still",
"which",
"staining"
] |
[
{
"code": "MF9Y",
"title": "Other specified clinical findings on examination of urine, without diagnosis"
},
{
"code": "5C56.20",
"title": "Mucolipidosis"
},
{
"code": "3A51.1",
"title": "Sickle cell disease without crisis"
},
{
"code": "9A96.3",
"title": "Primary anterior uveitis"
},
{
"code": "3A61.Z",
"title": "Acquired pure red cell aplasia, unspecified"
},
{
"code": "CB2Z",
"title": "Pleural, diaphragm or mediastinal disorders, unspecified"
},
{
"code": "LA76",
"title": "Structural developmental anomalies of pleura"
},
{
"code": "MD31",
"title": "Pleurisy"
},
{
"code": "NB32.60",
"title": "Laceration of pleura"
},
{
"code": "2F91.Y&XA5TT2",
"title": "Neoplasms of unknown behaviour of pleura"
}
] |
=== ICD-11 CODES FOUND ===
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
Also known as: Other specified clinical findings on examination of urine, without diagnosis | Methaemoglobinuria | Other and unspecified abnormal findings in urine | Calciuria | Cells and casts in urine
[5C56.20] Mucolipidosis
Also known as: Mucolipidosis | Mucolipidosis type 3 | Pseudo-Hurler polydystrophy | Pseudo-Hurler disease | Mucolipidosis type 2
Excludes: Sialidosis (mucolipidosis type 1)
[3A51.1] Sickle cell disease without crisis
Definition: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may present with fatigue, shortness of breath, dizziness, headaches, pallor of skin or mucous membranes, and jaundice. This disorder is confirmed by identification of HbS mutation by genetic testing.
Also known as: Sickle cell disease without crisis | Hb-SS disease without crisis | HbSS without crisis | Sickle-cell anaemia without crisis | SCD - [sickle cell disease]
[9A96.3] Primary anterior uveitis
Definition: This refers to primary inflammation of the uvea. The uvea consists of the middle, pigmented, vascular structures of the eye and includes the iris, ciliary body, and choroid.
Also known as: Primary anterior uveitis | anterior chamber cell
[3A61.Z] Acquired pure red cell aplasia, unspecified
Also known as: Acquired pure red cell aplasia, unspecified | Acquired pure red cell aplasia | acquired red cell aplasia | red cell aplasia NOS | pure red cell aplastic anaemia
[CB2Z] Pleural, diaphragm or mediastinal disorders, unspecified
Also known as: Pleural, diaphragm or mediastinal disorders, unspecified
[LA76] Structural developmental anomalies of pleura
Definition: Anomalies of the lining of the lung (visceral pleura) and thoracic cavity (parietal pleura)
Also known as: Structural developmental anomalies of pleura | Malformations of pleura | anomaly of pleura | abnormal pleura | pleural anomaly
[MD31] Pleurisy
Definition: Pleurisy or Pleuritis is the medical term for inflammation of the pleura. The most common cause of pleuritis is infection, but it can also be caused by lupus, rheumatoid arthritis, and certain medicines. Pleurisy or pleuritis usually accumulates exudative pleural effusions.
Also known as: Pleurisy | pleuritis | pleurisy NOS | double pleurisy | pleurisy without effusion
Excludes: pleurisy with effusion
[NB32.60] Laceration of pleura
Also known as: Laceration of pleura
=== GRAPH WALKS ===
--- Walk 1 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--EXCLUDES--> [?] Inborn errors of carbohydrate metabolism
--- Walk 2 ---
[MF9Y] Other specified clinical findings on examination of urine, without diagnosis
--PARENT--> [?] Clinical findings on examination of urine, without diagnosis
--EXCLUDES--> [?] Inborn errors of amino acid or other organic acid metabolism
--- Walk 3 ---
[5C56.20] Mucolipidosis
--EXCLUDES--> [?] Sialidosis
--CHILD--> [?] Sialidosis type 1
Def: Type 1 sialidosis, also called normomorphic or 'cherry-red-spot, myoclonus' syndrome is a form of sialidosis, a lysosomal storage disease belonging to the group of oligosaccharidoses or glycoproteinos...
--- Walk 4 ---
[5C56.20] Mucolipidosis
--RELATED_TO--> [?] Wolman disease
Def: Wolman disease represents the most severe manifestation of lysosomal acid lipase deficiency and can present in the fetus (hepatomegaly, ascites, calcified adrenal glands), or more typically in the fir...
--PARENT--> [?] Lysosomal acid lipase deficiency
Def: Lysosomal Acid Lipase (LAL) Deficiency happens when the body does not produce enough active lysosomal acid lipase (LAL or LIPA) enzyme. This enzyme plays an important role in breaking down fatty mater...
--- Walk 5 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--CHILD--> [3A51.2] Sickle cell disease with crisis
Def: Sickle cell crisis occurs when the sickle cells block blood flow, thus decreasing oxygen delivery to the tissues. This results in intense to severe pain in the extremities, lower back, abdomen, and ch...
--- Walk 6 ---
[3A51.1] Sickle cell disease without crisis
Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...
--PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies
Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...
--RELATED_TO--> [?] Osteonecrosis due to haemoglobinopathy
|
[
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --EXCLUDES--> [?] Inborn errors of carbohydrate metabolism",
"[MF9Y] Other specified clinical findings on examination of urine, without diagnosis\n --PARENT--> [?] Clinical findings on examination of urine, without diagnosis\n --EXCLUDES--> [?] Inborn errors of amino acid or other organic acid metabolism",
"[5C56.20] Mucolipidosis\n --EXCLUDES--> [?] Sialidosis\n --CHILD--> [?] Sialidosis type 1\n Def: Type 1 sialidosis, also called normomorphic or 'cherry-red-spot, myoclonus' syndrome is a form of sialidosis, a lysosomal storage disease belonging to the group of oligosaccharidoses or glycoproteinos...",
"[5C56.20] Mucolipidosis\n --RELATED_TO--> [?] Wolman disease\n Def: Wolman disease represents the most severe manifestation of lysosomal acid lipase deficiency and can present in the fetus (hepatomegaly, ascites, calcified adrenal glands), or more typically in the fir...\n --PARENT--> [?] Lysosomal acid lipase deficiency\n Def: Lysosomal Acid Lipase (LAL) Deficiency happens when the body does not produce enough active lysosomal acid lipase (LAL or LIPA) enzyme. This enzyme plays an important role in breaking down fatty mater...",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --CHILD--> [3A51.2] Sickle cell disease with crisis\n Def: Sickle cell crisis occurs when the sickle cells block blood flow, thus decreasing oxygen delivery to the tissues. This results in intense to severe pain in the extremities, lower back, abdomen, and ch...",
"[3A51.1] Sickle cell disease without crisis\n Def: A disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may pr...\n --PARENT--> [3A51] Sickle cell disorders or other haemoglobinopathies\n Def: Any disorder caused by a HbS mutation in the haemoglobin gene. This disorder is characterised by abnormal rigid sickle-shaped red blood cells decreasing its ability to carry oxygen. This disorder may ...\n --RELATED_TO--> [?] Osteonecrosis due to haemoglobinopathy"
] |
MF9Y
|
Other specified clinical findings on examination of urine, without diagnosis
|
[
{
"from_icd11": "3A51.1",
"icd10_code": "D571",
"icd10_title": "Sickle-cell disease without crisis"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D609",
"icd10_title": "Acquired pure red cell aplasia, unspecified"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D608",
"icd10_title": "Other acquired pure red cell aplasias"
},
{
"from_icd11": "3A61.Z",
"icd10_code": "D60",
"icd10_title": "Acquired pure red cell aplasia [erythroblastopenia]"
},
{
"from_icd11": "CB2Z",
"icd10_code": "J948",
"icd10_title": "Other specified pleural conditions"
},
{
"from_icd11": "CB2Z",
"icd10_code": "J949",
"icd10_title": "Pleural condition, unspecified"
},
{
"from_icd11": "CB2Z",
"icd10_code": "J90-J94",
"icd10_title": ""
},
{
"from_icd11": "CB2Z",
"icd10_code": "J94",
"icd10_title": "Other pleural conditions"
},
{
"from_icd11": "LA76",
"icd10_code": "Q340",
"icd10_title": "Anomaly of pleura"
},
{
"from_icd11": "MD31",
"icd10_code": "R091",
"icd10_title": "Pleurisy"
}
] |
D571
|
Sickle-cell disease without crisis
|
At the age of 21 the patient presented with a SRSE lasting for 8 weeks. During this episode 4 unsuccessful attempts were made to wake her up. Other complications during the SE episode were pneumonia (three times), derangement of transaminases and ammonia but not to harmful levels, and critical illness neuropathy. ASM given during the SRSE were valproate, clonazepam, levetiracetam, zonisamide, sultinam, clobazam, and perampanel. Sedatives/ anesthetics applied were propofol, ketamin, midazolam, fentanyl, thiopental, and dexmedetomidine. Other treatments used were high dosage methylprednisolone, anakinra, magnesium infusion, and ketogenic diet. All medications were given in accordance with the general practice for SE treatment in our hospital, in adequate doses and for long enough time . EEG and MR findings performed during and after the SRSE are presented in Fig. 1 , Fig. 2 respectively. After 7 weeks in SRSE at a time point where retraction of all active treatment was considered, functional hemispherotomy was performed. Histopathology showed brain tissue with dysmorphic neurons, balloon cells and altered cortical lamination, compatible with focal cortical dysplasia type IIb or hemimegaloencephaly. Fig. 1 Cerebral MRI at 4 different time points during the disease course. A) Age 9: MRI supposed to be normal, however retrospectively one can see signs of hemispheric asymmetry suggesting left-sided hemimegalencephaly. B) Age 21: three weeks after SRSE onset: MRI with clear left-sided hemimegaloencephaly. with diffuse confluent T2/Flair hyperintensity in white matter in left fronto-parietal region representing white matter demyelination and gliosis. C) MRI 3 weeks after surgery: Status after left-sided functional hemispherotomy. Pronounced edema in the left hemisphere with a midline shift of 11 mm to the right. Mainly signs of vasogenic edema in the basal ganglia on the left side. D) MRI 3 months after surgery: Status post left-sided functional hemispherotomy with encephalomalacia and resection defects in the left cerebral hemisphere. Resorption of blood, now with remaining blood products/hemosiderin in the form of scattered small low-signal foci in the resection cavity and linearly along the edge of the resection frontoparietally and temporally. Thickened dura under the craniotomy on the left side and a narrow (2–3 mm) extra-axial residual rim that may contain blood-mixed fluid. Reduction of postoperative parenchymal edema in the left cerebral hemisphere and regression of mass effect. Fig. 2 Excerpts from EEG monitoring during the SRSE episodes and 4 months after functional hemispherotomy. A) EEG 2 weeks after SRSE onset under deep sedation. Longitudinal montage, vertical lines indicate 1-second intervals. Top panel showing the corresponding amplitude-integrated EEGs (F3-P3/F4-P4) and spectrograms (F3-O1/F4-O2) over a 4 h period. ASM: Valproate, Zonisamide, Sultinam. Sedatives/anesthetics: Propofol, Thiopental. The EEG shows a burst-suppression pattern with short bursts from 1 to 3 s alternating with suppression periods of 1–3 s. The majority of the bursts may be characterized as highly epileptiform, containing multiple left hemispheric epileptiform discharges. B) EEG 3.5 weeks after SRSE onset under the second attempt to wake up the patient. Longitudinal montage, vertical lines indicate 1-second intervals. Top panel showing the corresponding amplitude-integrated EEGs (F3-P3/F4-P4) and spectrograms (F3-O1/F4-O2) over a 4 h period. ASM: Sultinam, Valproate, Brivaracetam, Clobazam. Sedatives/anesthetics: Dexmedetomidine. Other: Meropenem (pneumonia). The EEG shows the end of an electroencephalographic seizure from the left frontocentral area with spreading to the midline and right frontal area. The amplitude-integrated EEGs and spectrograms show repeated seizures (>35) almost without free interval in the first 2 h period (seizures are seen as abrupt increases in amplitude and high frequencies). C) EEG 5 weeks after SRSE onset under the third weaning attempt. Longitudinal montage, vertical lines indicate 1-second intervals. Top panel showing the corresponding amplitude-integrated EEGs (F3-P3/F4-P4) and spectrograms (F3-O1/F4-O2) over a 4 h period. ASM: Brivaracetam, Clonazepam, Perampanel, Clobazam. Sedatives/anesthetics: Propofol. Other: The EEG shows the beginning of an electroencephalographic seizure from the left frontocentral area spreading to the entire left hemisphere as well as the midline. The amplitude-integrated EEGs and spectrograms show repeated left hemispheric seizures visible as abrupt increases in amplitude and high frequencies over a 4 h period of time. D) EEG 4 months after the acute functional hemispherotomy. Longitudinal montage, vertical lines indicate 1-second intervals. Top panel showing the corresponding spectrograms (F3-O1/F4-O2) over a 20 min period. ASM: Brivaracetam, Clobazam, Perampanel. The EEG shows sporadic spikes and polyspikes in the left frontal area combined with left hemispheric slowing. Normal activity in the right hemisphere with an 8 Hz posterior dominant rhythm upon eyes closure. No ictal activity.
| 4.144531
| 0.954102
|
sec[1]/sec[2]/p[0]
|
en
| 0.999996
|
PMC11625172
|
https://doi.org/10.1016/j.ebr.2024.100728
|
[
"srse",
"amplitude",
"spectrograms",
"period",
"functional",
"hemispherotomy",
"hemisphere",
"integrated",
"eegs",
"over"
] |
[
{
"code": "4A60.0",
"title": "Familial Mediterranean fever"
},
{
"code": "GA20.3",
"title": "Abnormal regularity of uterine bleeding"
},
{
"code": "8C74.1Z",
"title": "Periodic paralysis, unspecified"
},
{
"code": "MD11.Y",
"title": "Other specified abnormalities of breathing"
},
{
"code": "GA20.50",
"title": "Heavy menstrual bleeding"
},
{
"code": "DD91.Z",
"title": "Irritable bowel syndrome or functional bowel disorders, unspecified"
},
{
"code": "9E1Z",
"title": "Diseases of the visual system, unspecified"
},
{
"code": "6B60.Z",
"title": "Dissociative neurological symptom disorder, with unspecified symptoms"
},
{
"code": "6B60.8Y",
"title": "Dissociative neurological symptom disorder, with other specified movement disturbance"
},
{
"code": "6B60.3",
"title": "Dissociative neurological symptom disorder, with other sensory disturbance"
}
] |
=== ICD-11 CODES FOUND ===
[4A60.0] Familial Mediterranean fever
Definition: FMF is an autoinflammatory disease associated with mutations in pyrin resulting in enhanced IL1 beta production. This results in clinical attacks of inflammation in the form of fever and serositis in the form of peritoneal, pleural or synovial inflammation along with increased acute phase reactants.
Also known as: Familial Mediterranean fever | Periodic disease | FMF - [familial mediterranean fever] | periodic fever | periodic polyserositis
[GA20.3] Abnormal regularity of uterine bleeding
Definition: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days.
Also known as: Abnormal regularity of uterine bleeding | Irregular menstrual bleeding | irregular cycle menstruation | irregular menses | irregular menstrual cycle
[8C74.1Z] Periodic paralysis, unspecified
Also known as: Periodic paralysis, unspecified | Periodic paralysis | Westphal disease | periodic myotonia | myoplegic dystrophy
[MD11.Y] Other specified abnormalities of breathing
Also known as: Other specified abnormalities of breathing | Bradypnoea | Choking sensation | Hypoventilation | hypoventilation syndrome NOS
[GA20.50] Heavy menstrual bleeding
Definition: Menstruation with heavy (> 80 ml) volume of monthly blood loss
Also known as: Heavy menstrual bleeding | menstruation excessive | Heavy menstrual bleeding caused by bleeding disorders | Excessive menstruation with regular cycle | excessive menses
[DD91.Z] Irritable bowel syndrome or functional bowel disorders, unspecified
Also known as: Irritable bowel syndrome or functional bowel disorders, unspecified | Irritable bowel syndrome or certain specified functional bowel disorders | Functional intestinal disorders NOS
[9E1Z] Diseases of the visual system, unspecified
Also known as: Diseases of the visual system, unspecified | eye diseases NOS | disorder of vision | visual disorder
[6B60.Z] Dissociative neurological symptom disorder, with unspecified symptoms
Also known as: Dissociative neurological symptom disorder, with unspecified symptoms | Dissociative neurological symptom disorder | Functional neurological disorders | Functional neurological symptom disorder | Conversion disorder
[6B60.8Y] Dissociative neurological symptom disorder, with other specified movement disturbance
Also known as: Dissociative neurological symptom disorder, with other specified movement disturbance | Functional movement disorder | Other functional hyperkinetic movements
[6B60.3] Dissociative neurological symptom disorder, with other sensory disturbance
Definition: Dissociative neurological symptom disorder, with other sensory disturbance is characterised by sensory symptoms not identified in other specific categories in this grouping such as numbness, tightness, tingling, burning, pain, or other symptoms related to touch, smell, taste, balance, proprioception, kinesthesia, or thermoception. The symptoms are not consistent with a recognised disease of the nervous system, other mental, behavioural or neurodevelopmental disorder, or other medical condition a
Also known as: Dissociative neurological symptom disorder, with other sensory disturbance | Functional neurological symptom disorder, with alteration of sensation | Functional sensory disorder | Functional neurological symptom disorder, with other sensory disturbance
=== GRAPH WALKS ===
--- Walk 1 ---
[4A60.0] Familial Mediterranean fever
Def: FMF is an autoinflammatory disease associated with mutations in pyrin resulting in enhanced IL1 beta production. This results in clinical attacks of inflammation in the form of fever and serositis in ...
--PARENT--> [4A60] Monogenic autoinflammatory syndromes
Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....
--CHILD--> [4A60.1] Cryopyrin-associated periodic syndromes
Def: CAPS is an autoinflammatory disease associated with gain of function changes in the cryopyrin protein, resulting in inflammasome activation and enhanced IL1 beta production. This results in clinical s...
--- Walk 2 ---
[4A60.0] Familial Mediterranean fever
Def: FMF is an autoinflammatory disease associated with mutations in pyrin resulting in enhanced IL1 beta production. This results in clinical attacks of inflammation in the form of fever and serositis in ...
--PARENT--> [4A60] Monogenic autoinflammatory syndromes
Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....
--CHILD--> [4A60.2] Tumour necrosis factor receptor 1 associated periodic syndrome
Def: TRAPS is an autoinflammatory disease associated with heterozygous mutations in the gene coding for tumour necrosis factor (TNF) receptor 1 (TNFR1). This results in clinical attacks of inflammation in ...
--- Walk 3 ---
[GA20.3] Abnormal regularity of uterine bleeding
Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....
--PARENT--> [GA20] Menstrual cycle bleeding disorders
--CHILD--> [GA20.2] Ovulation bleeding
Def: A condition of the genital system affecting females, caused by natural and routine fluctuations in endocrine hormones. This condition is characterised by recurrent and cyclic bleeding of the uterine l...
--- Walk 4 ---
[GA20.3] Abnormal regularity of uterine bleeding
Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....
--PARENT--> [GA20] Menstrual cycle bleeding disorders
--CHILD--> [GA20.0] Amenorrhoea
Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...
--- Walk 5 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--PARENT--> [8C74] Periodic paralyses or disorders of muscle membrane excitability
Def: These are a group of disorders caused by malfunctioning of the ion channels in skeletal muscle membranes causing the cells to depolarize leading to weakness or paralysis. The common triggers include c...
--- Walk 6 ---
[8C74.1Z] Periodic paralysis, unspecified
--PARENT--> [8C74.1] Periodic paralysis
Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...
--CHILD--> [8C74.1Y] Other specified periodic paralysis
|
[
"[4A60.0] Familial Mediterranean fever\n Def: FMF is an autoinflammatory disease associated with mutations in pyrin resulting in enhanced IL1 beta production. This results in clinical attacks of inflammation in the form of fever and serositis in ...\n --PARENT--> [4A60] Monogenic autoinflammatory syndromes\n Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....\n --CHILD--> [4A60.1] Cryopyrin-associated periodic syndromes\n Def: CAPS is an autoinflammatory disease associated with gain of function changes in the cryopyrin protein, resulting in inflammasome activation and enhanced IL1 beta production. This results in clinical s...",
"[4A60.0] Familial Mediterranean fever\n Def: FMF is an autoinflammatory disease associated with mutations in pyrin resulting in enhanced IL1 beta production. This results in clinical attacks of inflammation in the form of fever and serositis in ...\n --PARENT--> [4A60] Monogenic autoinflammatory syndromes\n Def: Monogenic hereditary autoinflammatory diseases characterised by apparently unprovoked generalised inflammation in the absence of infection or high titre autoantibodies....\n --CHILD--> [4A60.2] Tumour necrosis factor receptor 1 associated periodic syndrome\n Def: TRAPS is an autoinflammatory disease associated with heterozygous mutations in the gene coding for tumour necrosis factor (TNF) receptor 1 (TNFR1). This results in clinical attacks of inflammation in ...",
"[GA20.3] Abnormal regularity of uterine bleeding\n Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....\n --PARENT--> [GA20] Menstrual cycle bleeding disorders\n --CHILD--> [GA20.2] Ovulation bleeding\n Def: A condition of the genital system affecting females, caused by natural and routine fluctuations in endocrine hormones. This condition is characterised by recurrent and cyclic bleeding of the uterine l...",
"[GA20.3] Abnormal regularity of uterine bleeding\n Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....\n --PARENT--> [GA20] Menstrual cycle bleeding disorders\n --CHILD--> [GA20.0] Amenorrhoea\n Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --PARENT--> [8C74] Periodic paralyses or disorders of muscle membrane excitability\n Def: These are a group of disorders caused by malfunctioning of the ion channels in skeletal muscle membranes causing the cells to depolarize leading to weakness or paralysis. The common triggers include c...",
"[8C74.1Z] Periodic paralysis, unspecified\n --PARENT--> [8C74.1] Periodic paralysis\n Def: Rare group of neuromuscular disorders that are associated with defects in ion channels. Characterized by intermittent episodes of severe weakness of the limbs usually after heavy exercise, fasting, or...\n --CHILD--> [8C74.1Y] Other specified periodic paralysis"
] |
4A60.0
|
Familial Mediterranean fever
|
[
{
"from_icd11": "4A60.0",
"icd10_code": "D8982",
"icd10_title": "Autoimmune lymphoproliferative syndrome [ALPS]"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D89813",
"icd10_title": "Graft-versus-host disease, unspecified"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D89810",
"icd10_title": "Acute graft-versus-host disease"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D89811",
"icd10_title": "Chronic graft-versus-host disease"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D8989",
"icd10_title": "Other specified disorders involving the immune mechanism, not elsewhere classified"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D89812",
"icd10_title": "Acute on chronic graft-versus-host disease"
},
{
"from_icd11": "4A60.0",
"icd10_code": "D898",
"icd10_title": "Other specified disorders involving the immune mechanism, not elsewhere classified"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N926",
"icd10_title": "Irregular menstruation, unspecified"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N925",
"icd10_title": "Other specified irregular menstruation"
},
{
"from_icd11": "8C74.1Z",
"icd10_code": "G723",
"icd10_title": "Periodic paralysis"
},
{
"from_icd11": "DD91.Z",
"icd10_code": "K598",
"icd10_title": "Other specified functional intestinal disorders"
},
{
"from_icd11": "DD91.Z",
"icd10_code": "K599",
"icd10_title": "Functional intestinal disorder, unspecified"
},
{
"from_icd11": "DD91.Z",
"icd10_code": "K592",
"icd10_title": "Neurogenic bowel, not elsewhere classified"
},
{
"from_icd11": "DD91.Z",
"icd10_code": "K55-K64",
"icd10_title": ""
},
{
"from_icd11": "DD91.Z",
"icd10_code": "K59",
"icd10_title": "Other functional intestinal disorders"
}
] |
D8982
|
Autoimmune lymphoproliferative syndrome [ALPS]
|
Notably, she had severe hypovitaminosis and mineral deficiencies that improved only minimally despite repletion (Table 1 ). Given a newly-diagnosed ITP, hematochezia, sicca syndrome, and persistently low pre-albumin level, she underwent an extensive additional work-up to investigate the possibility of an underlying etiology contributing to her nutritional deficiency. Her diagnostic work-up included broad titer analyses (Tables 2 and 3 ), blood/urine/stool analyses, esophagogastroduodenoscopy with biopsy, and colonoscopy with biopsy. Negative biopsy findings and associated autoantibody, viral, fungal, and bacterial titers ruled out the more common autoimmune and infectious causes of malabsorption, such as IBD and celiac disease (Table 3 ). Our patient was eventually diagnosed with AIE based on jejunal biopsy findings of mild increase in intraepithelial lymphocytes, crypt apoptosis, reactive epithelial changes, and mild mononuclear and neutrophil expansion of the lamina propria, supported by positive anti-gastric parietal cell and anti-smooth muscle autoantibodies. Other reported associations with AIE, including sicca syndrome, gastritis, nephrotic syndrome, autoimmune hepatitis, and chronic pancreatitis, were also present in this patient, further supporting the diagnosis. She was discharged after 20 days with central parenteral nutrition (CPN), prednisone 15 mg daily, and close outpatient follow-up with markedly improved dermatologic findings. Follow-up visit at our dermatology clinic 15 weeks later was unremarkable with no recurrence of cutaneous findings (Table 4 ). At the time of manuscript submission, patient has remained stable without further hospitalization nor recurrence of symptoms. She continued to require CPN and oral supplements with weekly nutritionist monitoring and periodic gastroenterology follow-up. Table 2 Abnormal titre results for autoantibodies, viruses, fungi, and bacterial toxins Titre Names Results Reference Range Abnormal results: Anti-Ro (SSA) Ab Moderate Positive Negative Gastric parietal cell Ab 55.5 units ≤20 units = Negative Smooth muscle Ab Positive Negative C3, serum 71 mg/dL 79–251 mg/dL CMV viral load 2640 IU/mL <137 IU/mL Ab = antibody CMV = Cytomegalovirus Table 3 Titre results within normal range for autoantibodies, viruses, fungi, and bacterial toxins Titre Names Alpha-1 anti-trypsin, stool, 24-h Anti-Jo-1 Ab Direct anti-globulin test p-ANCA Anti-La (SSB) Ab Glomerular basement membrane Ab c-ANCA Anti-nuclear Ab (ANA) Islet cell Ab Anti-cardiolipin Ab, IgG Anti-Scl70 Ab Liver-kidney microsomal Ab Anti-cardiolipin Ab, IgM Anti-Smith Ab Mitochondrial Ab Anti-cardiolipin Ab, IgA Anti-URP Ab Rheumatoid factor Anti-dsDNA Ab Beta-2 glycoprotein Ab, IgG Thyroglobulin Ab Anti-enterocyte Ab, IgG Beta-2 glycoprotein Ab, IgM Thyroid peroxidase microsomal Ab Anti-enterocyte Ab, IgM Beta-2 glycoprotein Ab, IgA Tissue transglutaminase, IgA Anti-enterocyte Ab, IgA Cyclic citrul peptide Ab TSH receptor Ab C4, serum EBV viral load C.difficile toxin B gene NAT CH50, serum (1–3)-Beta-D-Glucan Diphtheria antitoxin Ab Galactomannan, serum Ab = antibody p-ANCA = perinuclear anti-neutrophilic cytoplasmic antibody c-ANCA = cytoplasmic anti-neutrophilic cytoplasmic antibody ANA = Antinuclear Antibody EBV = Epstein-Barr Virus TSH = Thyroid-Stimulating Hormone Table 4 Case report timeline Chronology Timeline Description T 0 –4 months Clinical presentation: dysgeusia, lower extremity edema, and cutaneous eruption and erythema of the lower extremities and acral region with desquamation Management: refractory to topical triamcinolone 0.1% ointment T 0 –3 months Clinical presentation: symptoms persisted with additional blurring of vision, xerostomia, diarrhea, hematochezia, anorexia, and thrombocytopenia Diagnosis: immune thrombocytopenic purpura (ITP) and non-alcoholic steatohepatitis Management: 22-day hospitalization, prednisone 60 mg and discharged with a 4-week taper T 0 –2 months Clinical presentation: recurring edema in the lower extremities progressing rapidly to painful desquamative and vesiculobullous lesions Diagnosis: eczematous dermatitis Diagnostic tests: skin biopsy Management: second hospitalization, discharged with another 4-week prednisone taper Comments: developed sacral pressure ulcer T 0 Clinical presentation: persistent edema, non-healing sacral ulcer, worsening desquamative plaques Diagnosis: acquired acrodermatitis enteropathica and severe nutrition deficiency Diagnostic tests: skin biopsy of the right medial malleolus, broad titre analyses, esophagogastroduodenoscopy and colonoscopy with biopsy Management: broad nutrition repletion T 0 + 3 weeks Clinical presentation: marked improvements of cutaneous findings and gastrointestinal function Diagnosis: adult autoimmune enteropathy Management: discharged with central parenteral nutrition (CPN), prednisone 15 mg daily, and close outpatient follow-up T 0 + 4 months Clinical presentation: outpatient follow-up with unremarkable cutaneous findings Management: continue CPN and oral supplements, close outpatient follow-up with gastroenterology and nutrition
| 4.277344
| 0.915527
|
sec[1]/p[4]
|
en
| 0.999997
|
28521835
|
https://doi.org/10.1186/s12895-017-0059-4
|
[
"anti",
"biopsy",
"nutrition",
"titre",
"antibody",
"discharged",
"prednisone",
"outpatient",
"cutaneous",
"serum"
] |
[
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MB23.1",
"title": "Antisocial behaviour"
},
{
"code": "3B4Z",
"title": "Coagulation defects, unspecified"
},
{
"code": "4A45.Z",
"title": "Antiphospholipid syndrome, unspecified"
},
{
"code": "4A43.Y",
"title": "Other specified overlap non-organ specific systemic autoimmune disease"
},
{
"code": "JA85.Y",
"title": "Maternal care for other specified fetal abnormality or damage"
},
{
"code": "KD39.3",
"title": "Fetus or newborn affected by complications of fetal surgery"
},
{
"code": "PK81.5",
"title": "Biopsy procedure, not elsewhere classified, associated with injury or harm in therapeutic use"
},
{
"code": "PK81.4",
"title": "Bone marrow aspiration or biopsy associated with injury or harm in therapeutic use"
},
{
"code": "PK98.0",
"title": "Radiological devices associated with injury or harm, diagnostic or monitoring devices"
}
] |
=== ICD-11 CODES FOUND ===
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MB23.1] Antisocial behaviour
Definition: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated.
Also known as: Antisocial behaviour | Child or adolescent antisocial behaviour
[3B4Z] Coagulation defects, unspecified
Also known as: Coagulation defects, unspecified | blood clotting disturbance | blood clotting defect | blood clotting factor deficiency | clotting abnormality
[4A45.Z] Antiphospholipid syndrome, unspecified
Also known as: Antiphospholipid syndrome, unspecified | Antiphospholipid syndrome | Hughes syndrome | Anticardiolipin syndrome
[4A43.Y] Other specified overlap non-organ specific systemic autoimmune disease
Also known as: Other specified overlap non-organ specific systemic autoimmune disease | Antisynthetase syndrome | Reynolds syndrome | Syndromic multisystem autoimmune disease due to ITCH deficiency | Eosinophilia myalgia syndrome
[JA85.Y] Maternal care for other specified fetal abnormality or damage
Also known as: Maternal care for other specified fetal abnormality or damage | Maternal care for damage to fetus from alcohol | suspected damage to fetus from maternal alcohol addiction affecting management of mother | pregnancy management affected by fetal damage from maternal alcohol addiction | maternal care for known or suspected damage to fetus from alcohol
[KD39.3] Fetus or newborn affected by complications of fetal surgery
Definition: A condition in the fetus due to an unfavourable evolution of a condition (complication) associated with a surgical health intervention applied to the fetus.
Also known as: Fetus or newborn affected by complications of fetal surgery | Adverse outcome following fetal skin biopsy
[PK81.5] Biopsy procedure, not elsewhere classified, associated with injury or harm in therapeutic use
Also known as: Biopsy procedure, not elsewhere classified, associated with injury or harm in therapeutic use | complication during or following biopsy procedure, other than bone marrow
Excludes: Bone marrow aspiration or biopsy associated with injury or harm in therapeutic use | Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
[PK81.4] Bone marrow aspiration or biopsy associated with injury or harm in therapeutic use
Also known as: Bone marrow aspiration or biopsy associated with injury or harm in therapeutic use | complication during or following bone marrow aspiration or biopsy
Excludes: Circumstances associated with a surgical or other medical procedure influencing the episode of care, without injury or harm
[PK98.0] Radiological devices associated with injury or harm, diagnostic or monitoring devices
Also known as: Radiological devices associated with injury or harm, diagnostic or monitoring devices | Radiological devices associated with adverse incidents, malfunction of radiological apparatus | Radiological devices associated with adverse incidents, CT scanner or MRI causing physical injury | Radiological devices associated with adverse incidents, needles used in radiologically-guided biopsies
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
=== GRAPH WALKS ===
--- Walk 1 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--EXCLUDES--> [?] Labour or delivery complicated by fetal distress
--- Walk 2 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia
--- Walk 3 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.0] Aggressive behaviour
Def: Actions intended to threaten or hurt another person or to damage property that may be physical, verbal, or symbolic (e.g., acting against the other person's interests). Aggressive behaviour may be app...
--- Walk 4 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--PARENT--> [?] Mental or behavioural symptoms, signs or clinical findings
--- Walk 5 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--CHILD--> [?] Congenital or constitutional haemorrhagic condition
Def: A condition caused by determinants arising during the antenatal period or genetically inherited factors, leading to defects in clotting mechanisms or abnormalities causing structural flaws in the bloo...
--- Walk 6 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--CHILD--> [?] Haemorrhagic diseases due to acquired coagulation factor defects
Def: Any disease caused by determinants arising after birth. These diseases are characterised by abnormal coagulation of the blood....
|
[
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --EXCLUDES--> [?] Labour or delivery complicated by fetal distress",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --CHILD--> [JA86.2] Maternal care for signs of fetal hypoxia",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.0] Aggressive behaviour\n Def: Actions intended to threaten or hurt another person or to damage property that may be physical, verbal, or symbolic (e.g., acting against the other person's interests). Aggressive behaviour may be app...",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --PARENT--> [?] Mental or behavioural symptoms, signs or clinical findings",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --CHILD--> [?] Congenital or constitutional haemorrhagic condition\n Def: A condition caused by determinants arising during the antenatal period or genetically inherited factors, leading to defects in clotting mechanisms or abnormalities causing structural flaws in the bloo...",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --CHILD--> [?] Haemorrhagic diseases due to acquired coagulation factor defects\n Def: Any disease caused by determinants arising after birth. These diseases are characterised by abnormal coagulation of the blood...."
] |
JA86.Y
|
Maternal care for other specified fetal problems
|
[
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D688",
"icd10_title": "Other specified coagulation defects"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D689",
"icd10_title": "Coagulation defect, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D699",
"icd10_title": "Hemorrhagic condition, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D698",
"icd10_title": "Other specified hemorrhagic conditions"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D65-D69",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D69",
"icd10_title": "Purpura and other hemorrhagic conditions"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6861",
"icd10_title": "Antiphospholipid syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6869",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6862",
"icd10_title": "Lupus anticoagulant syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D686",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "JA85.Y",
"icd10_code": "O358XX0 ",
"icd10_title": ""
}
] |
O26841
| |
A 57-year-old Iranian female was referred to the infectious diseases department at Amiralmomenin Medical School hospital with jaundice, fever, body itching, abdominal pain, progressive muscle weakness, and pain from 1 week ago; on physical examination, she was found to have icteric sclera, right upper quadrant pain, and reduced muscle force. The patient had a history of diabetes mellitus (10 years), hypothyroidism, hyperlipidemia, hypertension, and diabetic foot 5 months ago. The patient’s drug history included atorvastatin [40 mg per oral (PO) every day (QD), acetylsalicylic acid (80 mg PO QD], losartan (25mg PO QD), ranitidine (150 mg PO every 12 hours), amlodipine (2.5 mg PO QD), and furosemide (40 mg PO QD). The patient has been using insulin for the past 2 years. The patient was admitted to the hospital with the clinical diagnosis of acute hepatitis and myopathy. Before acute hepatitis, the patient did not have serum creatine kinase (CK) elevation due to statin consumption. On neurological examination, at the time of admission, muscle strength was 4 out of 5 in upper limbs and 2 out of 5 in lower limbs. One day after being hospitalized, the patient developed urinary retention leading to catheterization. Then, the muscle weakness became so severe that the patient was unable to walk and do defecation. After 1 week, the patient was visited by a neurologist and rheumatologist. All joints were normal, but limb muscle force and strength of gluteal muscle and external anal sphincter decreased. Initial differential diagnoses were acute hepatitis, statin toxicity, and rhabdomyolysis. As reported in the tables, the patient’s lab results demonstrated that the virology test for HBV Ag was positive with a high viral load level; however, the tests for other hepatitis viruses and HBV Ab were negative (Table 1 ). At the first visit, lab tests demonstrated an increase in aminotransferases (ALT, AST), alkaline phosphatase, bilirubin, CK, lactate dehydrogenase (LDH), aldolase, and ferritin; however, the results improved 14 days later without any specific medication (Table 2 ). Table 1 Results of lab tests WBC 11,000/mm 3 Hbs Ag (ELISA) Positive RBC 327 × 10 4 /mm 3 HBe Ag Positive Platelet count 327,000 HBc Ab Positive HGB 10.5 g/dl HBc Ab IgM Positive > 15 IU/ml ESR 77 → 32 mm HBe Ab Negative C-reactive protein 10 mg/dl HDV Ab Negative Urea 52 mg/dl HCV Ab Negative Creatinine 1.2 mg/dl HIV Ab Negative Fe 85 mg/dl HBs Ab Negative TIBC 282 HEV Negative Calcium 8.5 mg/dl HAV Ab Negative Phosphorus 3.3 mg/dl HBV viral load 3,319,701,150 Copies/ml 570,395,386 IU/mL Prothrombin time (PT) 12.5 seconds Ferritin 960 ng/ml → 357 ng/ml Potassium 3.6 mEq/l Rheumatoid factor Negative Blood culture Negative ANA Negative Wright Negative p-ANCA Negative Coombs Wright Negative c-ANCA Negative Troponin Negative Anti-ds-DNA Negative Venereal disease research laboratory (VDRL) Negative Antimitochondrial Ab Negative Thyroxine (T4) 13 μg% Anti-smooth muscle Ab Negative Triiodothyronine (T3) 1.5 ng/ml Tissue transglutaminase Ab Negative Thyroid-stimulating hormone (TSH) 3.4 mlU/ml Anti-gliadin Ig G Negative Copper in a normal range In blood and urine Anti-gliadin IgA Negative Total protein 6.3 mg/dl LKM-1 Negative Albumin 3.4 mg/dl Anti-endomysial Ab Negative Urinalysis Normal Aldolase 40 IU/l Chest x-ray Normal Ceruloplasmin 31 mg/dl, normal HGB, Hemoglobin; ESR, Erythrocyte Sedimentation Rate; Fe, Iron; TSH, Thyroid-Stimulating Hormone; Hbs, Hepatitis B Surface; Hbc, Hepatitis B Core; HDV, Hepatitis D Virus; HCV, Hepatitis C Virus; HEV, Hepatitis E Virus; HAV, Hepatitis A Virus; HBV, Hepatitis B Virus; Ag, Antigen; Ab, Antibody; RF, Rheumatoid Factor; ANA, Antinuclear Antibodies; C-ANCA, Antineutrophil Cytoplasmic Autoantibody Cytoplasmic; P-ANCA, Perinuclear Anti-Neutrophil Cytoplasmic Antibodies; Ig, Immunoglubolin; →, shows the recovery process Table 2 Electromyography (EMG)/nerve conduction velocity (NCS) results Neuron site Nerve Muscle Result Sensory NCS L sural—Lat malleolus L calf Not obtainable R sural—Lat malleolus R calf Not obtainable L superficial peroneal—foot L Lat leg Not obtainable Motor NCS Tibial malleolus—abductor hallucis brevis Wrist Not obtainable Elbow Not obtainable L common peroneal—extensor digitorum brevis (EDB) Ankle Not obtainable Fibular head Not obtainable R common peroneal—EDB Ankle Not obtainable Fibular hand Not obtainable H-Reflex L tibial—soleus Knee Not obtainable R tibial—soleus Knee Not obtainable EMG L TIB Ant Mildly decreased L gastrocnemius—Lat Mildly decreased L vastus lateralis Early recruitment R vastus lateralis Early recruitment R biceps Early recruitment R deltoid Early recruitment Summary: (1) assessment motor and sensory nerve conduction was not possible at every neuron site; (2) on needle EMG examination, low-amplitude motor unit potentials (MUPs) with early recruitment were most prominent in proximal muscles of upper and lower limbs. Conclusion: The patient was found to exhibit (1) acute myopathic process and (2) chronic sensorimotor polyneuropathy. L, left; R, right; Lat, lateral; TIB, tibial; Ant, anterior
| 4.097656
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|
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|
en
| 0.999995
|
35395817
|
https://doi.org/10.1186/s13256-022-03330-w
|
[
"hepatitis",
"obtainable",
"muscle",
"anti",
"virus",
"recruitment",
"anca",
"tibial",
"pain",
"every"
] |
[
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "1E50.Z",
"title": "Acute viral hepatitis, unspecified"
},
{
"code": "DB97.2",
"title": "Chronic hepatitis, not elsewhere classified"
},
{
"code": "1E5Z",
"title": "Viral hepatitis, unspecified"
},
{
"code": "1E51.0Z",
"title": "Chronic hepatitis B, unspecified"
},
{
"code": "FB3Z",
"title": "Disorders of muscles, unspecified"
},
{
"code": "FB32.Y",
"title": "Other specified disorders of muscles"
},
{
"code": "8C70.Z",
"title": "Muscular dystrophy, unspecified"
},
{
"code": "FB32.2Z",
"title": "Ischaemic infarction of muscle, unspecified"
},
{
"code": "FB56.2",
"title": "Myalgia"
}
] |
=== ICD-11 CODES FOUND ===
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[1E50.Z] Acute viral hepatitis, unspecified
Also known as: Acute viral hepatitis, unspecified | Acute viral hepatitis | acute anicteric hepatitis | Acute hepatitis NOS | acute viral hepatitis non-A non-B NEC
[DB97.2] Chronic hepatitis, not elsewhere classified
Also known as: Chronic hepatitis, not elsewhere classified | Chronic hepatitis, unspecified | Chronic active hepatitis NEC | Other specified chronic hepatitis | Chronic persistent hepatitis NEC
Includes: Chronic hepatitis, unspecified | Other specified chronic hepatitis
Excludes: hepatitis (chronic): granulomatous NEC | Drug-induced or toxic liver disease | hepatitis (chronic): viral
[1E5Z] Viral hepatitis, unspecified
Also known as: Viral hepatitis, unspecified | anicteric hepatitis
[1E51.0Z] Chronic hepatitis B, unspecified
Also known as: Chronic hepatitis B, unspecified | Chronic hepatitis B | Chronic hepatitis B without delta agent | chronic HBV - [hepatitis B virus] infection | hepatitis B NOS
[FB3Z] Disorders of muscles, unspecified
Also known as: Disorders of muscles, unspecified | disorder of muscle, unspecified | muscle disease | muscular disease | muscular disorder
[FB32.Y] Other specified disorders of muscles
Also known as: Other specified disorders of muscles | Muscle wasting or atrophy, not elsewhere classified | muscle wasting | muscle wasting disorder | Sarcopenia
[8C70.Z] Muscular dystrophy, unspecified
Also known as: Muscular dystrophy, unspecified | Muscular dystrophy | Gower's muscular dystrophy | progressive musclular dystrophy | pseudohypertrophic atrophy
[FB32.2Z] Ischaemic infarction of muscle, unspecified
Also known as: Ischaemic infarction of muscle, unspecified | Ischaemic infarction of muscle | muscle infarction
[FB56.2] Myalgia
Definition: This is a disorder characterised by pain in a muscle or group of muscles.
Also known as: Myalgia | muscle ache | muscle soreness | muscular pain | myalgic
Excludes: Chronic primary musculoskeletal pain | Chronic secondary musculoskeletal pain
=== GRAPH WALKS ===
--- Walk 1 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--CHILD--> [DB97.0] Idiopathic granulomatous hepatitis
--- Walk 2 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--CHILD--> [DB97.1] Hepatic berylliosis
--- Walk 3 ---
[1E50.Z] Acute viral hepatitis, unspecified
--PARENT--> [1E50] Acute viral hepatitis
Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...
--EXCLUDES--> [?] Acute or subacute hepatic failure
Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....
--- Walk 4 ---
[1E50.Z] Acute viral hepatitis, unspecified
--PARENT--> [1E50] Acute viral hepatitis
Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...
--PARENT--> [?] Viral hepatitis
Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...
--- Walk 5 ---
[DB97.2] Chronic hepatitis, not elsewhere classified
--EXCLUDES--> [?] Drug-induced or toxic liver disease
Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....
--EXCLUDES--> [?] Budd-Chiari syndrome
Def: Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava and leading to hepatic congestion and...
--- Walk 6 ---
[DB97.2] Chronic hepatitis, not elsewhere classified
--EXCLUDES--> [?] Viral hepatitis
Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...
--EXCLUDES--> [?] Non-alcoholic steatohepatitis
Def: Non-alcoholic steatohepatitis (NASH) is a histological form of Non-alcoholic fatty liver disease (NAFLD) in which the key features are histological evidence of hepatocyte injury (such as ballooning or...
|
[
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --CHILD--> [DB97.0] Idiopathic granulomatous hepatitis",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --CHILD--> [DB97.1] Hepatic berylliosis",
"[1E50.Z] Acute viral hepatitis, unspecified\n --PARENT--> [1E50] Acute viral hepatitis\n Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...\n --EXCLUDES--> [?] Acute or subacute hepatic failure\n Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....",
"[1E50.Z] Acute viral hepatitis, unspecified\n --PARENT--> [1E50] Acute viral hepatitis\n Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...\n --PARENT--> [?] Viral hepatitis\n Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...",
"[DB97.2] Chronic hepatitis, not elsewhere classified\n --EXCLUDES--> [?] Drug-induced or toxic liver disease\n Def: Drug-induced or toxic liver disease is hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent....\n --EXCLUDES--> [?] Budd-Chiari syndrome\n Def: Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava and leading to hepatic congestion and...",
"[DB97.2] Chronic hepatitis, not elsewhere classified\n --EXCLUDES--> [?] Viral hepatitis\n Def: A group of liver diseases caused by infection with one or more of the five hepatitis viruses, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E viruses. The in...\n --EXCLUDES--> [?] Non-alcoholic steatohepatitis\n Def: Non-alcoholic steatohepatitis (NASH) is a histological form of Non-alcoholic fatty liver disease (NAFLD) in which the key features are histological evidence of hepatocyte injury (such as ballooning or..."
] |
DB97.Z
|
Inflammatory liver disease, unspecified
|
[
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K758",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "1E50.Z",
"icd10_code": "B179",
"icd10_title": "Acute viral hepatitis, unspecified"
},
{
"from_icd11": "1E50.Z",
"icd10_code": "B178",
"icd10_title": "Other specified acute viral hepatitis"
},
{
"from_icd11": "1E50.Z",
"icd10_code": "B17",
"icd10_title": "Other acute viral hepatitis"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K739",
"icd10_title": "Chronic hepatitis, unspecified"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K732",
"icd10_title": "Chronic active hepatitis, not elsewhere classified"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K738",
"icd10_title": "Other chronic hepatitis, not elsewhere classified"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K73",
"icd10_title": "Chronic hepatitis, not elsewhere classified"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K730",
"icd10_title": "Chronic persistent hepatitis, not elsewhere classified"
},
{
"from_icd11": "DB97.2",
"icd10_code": "K731",
"icd10_title": "Chronic lobular hepatitis, not elsewhere classified"
}
] |
K7581
|
Nonalcoholic steatohepatitis (NASH)
|
A 24-year-old patient in the 37 th week of spontaneous pregnancy, gravida 1, parity 0, was admitted at our obstetrics clinic with the start of labor. The patient’s pregnancy controls were taking place at our obstetrics outpatient clinic as from the 31 st week of pregnancy. An abdominal ultrasonography performed when the patient was seventeen years old revealed a cirrhotic liver. The biochemical test results showed a ceruloplasmin level of 10.1mg/dl (25.0-45.0 mg/dl), free copper levels of 71μgr/dl (normal <15 μgr/dl), a urine copper level of 120 μgr/24 hr (normal: <100 μgr/24 hrs), upon which a liver biopsy was performed leading to a diagnosis of Wilson’s disease. From an investigation into the patient’s family history, it was learned that a sibling had undergone a liver transplant due to Wilson’s disease. Also followed up by the gastroenterology outpatient clinic, the patient was being treated with 300 mg 3x1 of Metalcaptase (D-penicillamine) and 2x1 p.o. of Zinco (50 mg zinc) throughout her pregnancy but she stopped taking this treatment for the last three days. On the patient’s examination, blood pressure was 140/90 mmHg and in complete urinalysis, proteinuria was found to be at +++ level. Furthermore, the following results were obtained in the blood tests; AST: 45 U/L (5-40 U/L), ALT: 20 U/L (5-40 U/L), ALP: 216 U/L (40-150 U/L), LDH: 406 U/L (125-243 U/L), amylase: 47 U/L, total bilirubin: 1.2 mg/dL (0.2-1.2 mg/dL), direct bilirubin: 0.64 mg/dL (0-0.5 mg/dL), total protein: 4.7 g/dL (6.4-8.3 g/dL), albumin: 2 g/dL (3.5-5 g/dL), thrombocytes: 98x10 9 /L (150-300x10 9 /L). The patient was diagnosed with pre-eclampsia. The additional pelvic examination revealed pronounced cephalopelvic disproportion and a cesarean section was therefore carried out. The patient delivered a live 3050-gram male infant in cephalic presentation with an APGAR score of 7-9. The patient was followed up on the hospital ward in the postpartum period. A change in the laboratory tests was observed at 24 hours postoperatively. The clinical results were as follows: AST: 50 U/L (5-40 U/L), ALT: 19 U/L (5-40 U/L), total protein: 4.1 g/dL (6.4-8.3 g/dL), albumin: 1.6 g/dL (3.5-5 g/dl) and thrombocyte values: 89x10 9 /L (150-300x10 9 /L). A gastroenterological evaluation of the patient was ordered but the patient was discharged on the 2 nd day postoperatively on her own request. On the third postoperative day, the patient was admitted to the emergency room with the complaints of widespread swelling in the abdomen, vulva and legs. Physical examination revealed massive vulvar edema, pretibial edema in the lower extremities, and the abdomen was distended . Blood pressure was 140/90 mmHg, pulse rate was 87/min and temperature 36.8 ºC. Ultrasonography showed an uterus of postpartum size with widespread free fluid in the abdomen. The test results were as follows; Hb (hemoglobin): 10.2 g/L (11.7-15.5 gr/dL), hematocrit: 28.4% (37-44%), thrombocytes: 64x109/L (150-300x109/L), CRP: 58.99 mg/L (0-6 mg/L), AST: 89 U/L (5-40 U/L), ALT: 30 U/L (5-40U/L), ALP: 132 U/L (40-150 U/L), LDH: 305 U/L (125-243 U/L), total protein: 3.7 g/dL (6,4-8,3 g/dL), albumin: 1.5 g/dL (3.5-5 g/dL), total bilirubin: 3.0 mg/dL (0.2-1.2 mg/dL), direct bilirubin: 1.55 mg/dL (0-0.5 mg/dL). Widespread pulmonary infiltration was observed in posteroanterior direct X-ray. After an internal medicine examination of the patient, human albumin replacement and treatment with a diuretic was planned. The patient was kept under close monitoring and control. After the consultation of gastroenterology department, administration of metalceptase (D-penicillamine) 2x1, aldactone (spironolactone 100 mg) 1x1, desal (furosemide 40 mg) 1x1 were recommended. The treatment, which is ongoing, resulted in slight regression in symptoms of liver failure such as vulvar edema, abdominal ascites, pulmonary edema and shortness of breath. The diagnosis given by gastroenterology department was WD-related acute liver failure. Laboratory tests showed AST: 87 U/L (5-40 U/L), ALT: 39 U/L (5-40 U/L) and LDH: 393 U/L (125-243 U/L), albumin: 2.5 g/dL (3.5-5 g/dL). Hematological tests showed leukopenia (WBC: 2.07x10 9 /L, normal: 4.1-10.9x10 9 /L) and a drop in blood values (Hb): 10.7 g/L (11,7-15.5 gr/dL), hematocrit (Hct): 30.1% (37.0-44%), RBC: 3.30x106/mcrL (3.83-5.08 106/mcrL), PLT: 40x10 9 /L (150-300x10 9 /L). The values in the coagulation profile were; prothrombin time (INR-international normalized ratio): 1.29 (08-1.2), Aptt: 41.1s (26.6-40.0), fibrinogen: 142 (180-350), D-dimer: 4871 (50-228). Kidney function tests were normal. When a full recovery could not be seen in the clinical and laboratory findings with the ongoing treatment and because of the need for a liver transplantation in the long term, the patient was referred to a hospital that had an organ transplantation department. The patient has been waiting her turn for a liver transplantation for the last two months and the current treatment continues, (the consent of the patient has been obtained, verbally and in written form, for the presentation of this case study).
| 3.958984
| 0.979492
|
sec[1]/p[0]
|
en
| 0.999995
|
28913043
|
https://doi.org/10.4274/tjod.24434
|
[
"liver",
"total",
"albumin",
"pregnancy",
"blood",
"bilirubin",
"edema",
"clinic",
"gastroenterology",
"direct"
] |
[
{
"code": "DB9Z",
"title": "Diseases of liver, unspecified"
},
{
"code": "DB97.Z",
"title": "Inflammatory liver disease, unspecified"
},
{
"code": "DB99.7",
"title": "Hepatic failure without mention whether acute or chronic"
},
{
"code": "LB20.0Y",
"title": "Other specified structural developmental anomalies of liver"
},
{
"code": "LB20.0Z",
"title": "Structural developmental anomalies of liver, unspecified"
},
{
"code": "MB5Z",
"title": "Paralytic symptoms, unspecified"
},
{
"code": "LB9B",
"title": "Reduction defects of upper and lower limbs"
},
{
"code": "LA85.1",
"title": "Transposition of the great arteries"
},
{
"code": "LD40.Y",
"title": "Other specified complete trisomies of the autosomes"
},
{
"code": "9D90.6",
"title": "Blindness"
}
] |
=== ICD-11 CODES FOUND ===
[DB9Z] Diseases of liver, unspecified
Also known as: Diseases of liver, unspecified | liver disease | liver condition NOS | organ liver disease | hepatopathy
[DB97.Z] Inflammatory liver disease, unspecified
Also known as: Inflammatory liver disease, unspecified | Certain specified inflammatory liver diseases | Nonspecific reactive hepatitis | inflammatory liver disease | hepatitis NOS
[DB99.7] Hepatic failure without mention whether acute or chronic
Also known as: Hepatic failure without mention whether acute or chronic | liver decompensation | liver function failure | hepatic failure NOS | liver failure NOS
[LB20.0Y] Other specified structural developmental anomalies of liver
Also known as: Other specified structural developmental anomalies of liver | Alagille syndrome | Alagille-Watson syndrome | Arteriohepatic dysplasia | Syndromic bile duct paucity
[LB20.0Z] Structural developmental anomalies of liver, unspecified
Also known as: Structural developmental anomalies of liver, unspecified | Structural developmental anomalies of liver | Malformations of liver | congenital anomaly of liver | congenital malformation of liver
[MB5Z] Paralytic symptoms, unspecified
Also known as: Paralytic symptoms, unspecified | paralysis syndrome | incomplete paralysis | complete paralysis | paresis
[LB9B] Reduction defects of upper and lower limbs
Also known as: Reduction defects of upper and lower limbs | Tetraamelia | Total amelia | Split hand - split foot | Acheiropodia
[LA85.1] Transposition of the great arteries
Definition: A congenital cardiovascular malformation in which the morphologically right ventricle or its remnant connects to the aorta and the morphologically left ventricle or its remnant connects to the pulmonary trunk.
Also known as: Transposition of the great arteries | Discordant ventriculoarterial connection | complete transposition of great vessels | great vessels complete transposition | great vessels transposition
[LD40.Y] Other specified complete trisomies of the autosomes
Also known as: Other specified complete trisomies of the autosomes | Other complete trisomies | entire chromosome trisomy, meiotic nondisjunction | Other trisomy mosaicism | Whole chromosome trisomy, mosaicism disorder
[9D90.6] Blindness
Definition: The numerical definition used for WHO statistics refers to profound, near-total or total loss. The functional definition refers to individuals who have little or no residual vision and who have to rely predominantly on vision substitution skills, i.e. on using senses other than vision (Braille or talking books for reading, a long cane or guide dog for mobility, or touch for manipulation).
Also known as: Blindness | acquired amaurosis | acquired blindness | amaurosis | blindness, both eyes
Includes: visual impairment category 5 | visual impairment categories 4, 5, 6 in both eyes | visual impairment categories 4, 5, 6 in one eye and categories 1, 2, 3 or 9 in the other eye
=== GRAPH WALKS ===
--- Walk 1 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--CHILD--> [DB90] Infectious liver disease
--- Walk 2 ---
[DB9Z] Diseases of liver, unspecified
--PARENT--> [?] Diseases of liver
--CHILD--> [DB91] Acute or subacute hepatic failure
Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....
--- Walk 3 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Acute or subacute hepatic failure
Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....
--- Walk 4 ---
[DB97.Z] Inflammatory liver disease, unspecified
--PARENT--> [DB97] Certain specified inflammatory liver diseases
--EXCLUDES--> [?] Acute viral hepatitis
Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...
--- Walk 5 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--CHILD--> [DB99.0] Chronic liver disease
--- Walk 6 ---
[DB99.7] Hepatic failure without mention whether acute or chronic
--PARENT--> [DB99] Certain specified diseases of liver
Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....
--RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium
Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium....
|
[
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --CHILD--> [DB90] Infectious liver disease",
"[DB9Z] Diseases of liver, unspecified\n --PARENT--> [?] Diseases of liver\n --CHILD--> [DB91] Acute or subacute hepatic failure\n Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Acute or subacute hepatic failure\n Def: Acute and subacute liver failure is characterised by onset of coagulopathy and/or hepatic encephalopathy within 8 weeks of onset of symptoms in a patient without previously known liver diseases....",
"[DB97.Z] Inflammatory liver disease, unspecified\n --PARENT--> [DB97] Certain specified inflammatory liver diseases\n --EXCLUDES--> [?] Acute viral hepatitis\n Def: A group of liver diseases characterised by liver inflammation and fibrosis, caused by less than 6 months of infection with one or more of hepatitis B virus, hepatitis C virus and hepatitis D virus, wi...",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --CHILD--> [DB99.0] Chronic liver disease",
"[DB99.7] Hepatic failure without mention whether acute or chronic\n --PARENT--> [DB99] Certain specified diseases of liver\n Def: This is a group of conditions characterised as being in or associated with the liver that are not classified elsewhere....\n --RELATED_TO--> [?] Liver disorders in pregnancy, childbirth or the puerperium\n Def: Any disorder affecting females, characterised by pathological changes to the liver that occur during pregnancy, childbirth, and the puerperium...."
] |
DB9Z
|
Diseases of liver, unspecified
|
[
{
"from_icd11": "DB9Z",
"icd10_code": "K7681",
"icd10_title": "Hepatopulmonary syndrome"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K7689",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K769",
"icd10_title": "Liver disease, unspecified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K77",
"icd10_title": "Liver disorders in diseases classified elsewhere"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K762",
"icd10_title": "Central hemorrhagic necrosis of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K70-K77",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K778",
"icd10_title": ""
},
{
"from_icd11": "DB9Z",
"icd10_code": "K72",
"icd10_title": "Hepatic failure, not elsewhere classified"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K76",
"icd10_title": "Other diseases of liver"
},
{
"from_icd11": "DB9Z",
"icd10_code": "K768",
"icd10_title": "Other specified diseases of liver"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7581",
"icd10_title": "Nonalcoholic steatohepatitis (NASH)"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K7589",
"icd10_title": "Other specified inflammatory liver diseases"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K759",
"icd10_title": "Inflammatory liver disease, unspecified"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K752",
"icd10_title": "Nonspecific reactive hepatitis"
},
{
"from_icd11": "DB97.Z",
"icd10_code": "K75",
"icd10_title": "Other inflammatory liver diseases"
}
] |
K7681
|
Hepatopulmonary syndrome
|
The PVCs and nonsustained VT were refractory to antiarrhythmic drugs, including β-blockers and mexiletine, and catheter ablation was performed. The PVCs exhibited a left bundle branch configuration with transitional zones of V 4 or V 5 , positive R waves in lead I, and notched tall QRS complexes in leads II and III on ECG, suggestive of a right ventricular outflow tract (RVOT) free wall origin . Catheter ablation was performed using a nonirrigated ablation catheter with a power setting of 35 W and a temperature setting of 55 °C. Earliest activation of the PVCs was recoded at the RVOT beneath the pulmonary valve, where pace mapping showed the identical QRS configuration. Radiofrequency (RF) applications at the earliest activation site failed to abolish the PVCs, and multiple RF applications resulted in serial changes in the QRS configuration. A decapolar catheter with a distal ring configuration, which was placed in the pulmonary artery (PA) above the pulmonary valve, recorded fragmented and delayed potentials during sinus rhythm, which preceded the PVC or nonsustained VT (PA potentials) . The potentials delayed as the catheter moved toward the distal PA during sinus rhythm. The earliest PA potential recorded in the bipolar electrodes of the circular catheter preceded the QRS onset by 94 ms during the PVC, and pace mapping at the electrodes was identical to the configuration of the PVC with the same interval from the stimulus to the QRS onset of 94 ms . RF applications beneath the pulmonary valve, where the earliest PA potentials recorded during sinus rhythm delayed and changed the sequence of the PA potentials and resulted in complete elimination of the PA potentials before encircling the entire PA, suggested that the entrance block of the conduction was between the RVOT and the PA . The total ablation duration was 7 minutes to achieve the PA isolation. After the elimination of the potentials, dissociated PA potentials were recorded (exit block), which indicated electrical isolation of the PA. The PVC and nonsustained VT gradually decreased during the additional RF applications and were completely abolished after the PA isolation. Figure 1 Surface Electrocardiogram of PVCs and Nonsustained Polymorphic PVT The configuration of the premature ventricular contractions (PVCs) and polymorphic ventricular tachycardia (PVT) exhibits positive R waves in lead I, notched tall QRS complexes in leads II and III, and a transitional zone in lead V 4 (black arrows) or V 5 (red arrows), suggesting the right ventricular outflow tract origin. Figure 2 Intracardiac Tracing During VT and Fluoroscopic Images in RAO and LAO Projections (A) Delayed fragmented potentials were recorded on one-half of the bipolar pairs of the ring catheter placed in the pulmonary artery (PA) during sinus rhythm (SR) (red arrows), whereas the potentials preceded the local ventricular potentials during the initiation of the ventricular tachycardia (VT) (black arrows). Note the changes in sequences of the earliest activation during the ventricular tachycardia, shown by the red arrows, suggesting multiple sites of the origins of the ventricular tachycardia in the pulmonary artery. (B and C) Right ventricular outflow tract angiography using a balloon angiographic catheter provided clear delineation of the attachment of the pulmonary valve (white arrows) and a decapolar circular catheter placed above the attachment of the pulmonary valve. ABL = ablation catheter; ECG = electrocardiogram; His = His bundle; LAO = left anterior oblique; RAO = right anterior oblique. Figure 3 Intracardiac Tracing During Sinus Rhythm and PVC With VT (A) The fragmented potentials (red arrows) delayed as the catheter moved toward the distal pulmonary artery (PA) during sinus rhythm, a finding suggesting that the potentials were pulmonary artery potentials. The earliest pulmonary artery potential recorded in bipolar electrode of pulmonary artery 8-9, which was the latest potential during sinus rhythm, preceded the QRS onset by 94 ms. (B) Pacing from the bipolar electrode where the earliest potential was recorded was identical to the configuration of the premature ventricular contraction (PVC) with the same interval from the stimulus to the QRS onset of 94 ms. Abbreviations as in Figure 2 . Figure 4 Intracardiac Tracing Before and After PA Isolation (A) Serial changes in the sequence of the pulmonary artery (PA) potentials recorded in the circular catheter during the radiofrequency applications beneath the pulmonary valve where the earliest pulmonary artery potentials were recorded (red arrows). (B) Radiofrequency applications resulted in complete elimination of the pulmonary artery potentials, thus suggesting the entrance block of the conduction between the right ventricular outflow tract and the pulmonary artery. After the elimination of the potentials, dissociated pulmonary artery potentials were recorded (red arrows), which indicated the bidirectional conduction block between the right ventricular outflow tract and the pulmonary artery (pulmonary artery isolation). Abbreviations as in Figure 2 .
| 4.375
| 0.55957
|
sec[4]/p[0]
|
en
| 0.999996
|
34825200
|
https://doi.org/10.1016/j.jaccas.2021.08.001
|
[
"pulmonary",
"potentials",
"artery",
"catheter",
"ventricular",
"recorded",
"arrows",
"earliest",
"configuration",
"sinus"
] |
[
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "LA75.1",
"title": "Agenesis of lung"
},
{
"code": "CA40.Z",
"title": "Pneumonia, organism unspecified"
},
{
"code": "CB41",
"title": "Respiratory failure"
},
{
"code": "NB32.3Y",
"title": "Other injury of lung"
},
{
"code": "DA95",
"title": "Coeliac disease"
},
{
"code": "MC21.Y",
"title": "Other specified impairment of electrophysiological functions"
},
{
"code": "EK92",
"title": "Histiocytoses of uncertain malignant potential"
},
{
"code": "QA53",
"title": "Pressure as potential mode of injury without injury or harm"
},
{
"code": "MA12.Y",
"title": "Other specified clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system"
}
] |
=== ICD-11 CODES FOUND ===
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[LA75.1] Agenesis of lung
Definition: This refers to the absence or rudimentary residua of an undeveloped lung.
Also known as: Agenesis of lung | Pulmonary agenesis | absence of lung | aplasia of lung | apulmonism
[CA40.Z] Pneumonia, organism unspecified
Also known as: Pneumonia, organism unspecified | Pneumonia | infectious pneumonia | PN - [pneumonia] | lobar pneumonia NOS
[CB41] Respiratory failure
Definition: Respiratory failure is a life-threatening impairment of oxygenation or carbon dioxide (CO2) elimination. Respiratory failure may occur because of impaired gas exchange, decreased ventilation, or both. The level of oxygen in the blood becomes dangerously low or the level of carbon dioxide becomes dangerously high.
Also known as: Respiratory failure | lung failure NOS | pulmonary failure
Excludes: Acute respiratory distress syndrome | Respiratory arrest | Respiratory distress of newborn
[NB32.3Y] Other injury of lung
Also known as: Other injury of lung | Haematoma of lung | Traumatic hydropneumothorax | Acute traumatic lung congestion | Rupture of lung
[DA95] Coeliac disease
Definition: Coeliac disease is a permanent intolerance to gluten proteins, present in wheat, rye, and barley. It is an autoimmune disorder, characterised by a chronic inflammatory state of the small intestinal mucosa and submucosa, which can impair digestion and absorption of nutrients, leading to malnutrition.
Also known as: Coeliac disease | Gluten-sensitive enteropathy | Nontropical sprue | coeliac rickets | Gee disease
Includes: Gluten-sensitive enteropathy | Nontropical sprue | Idiopathic steatorrhoea
[MC21.Y] Other specified impairment of electrophysiological functions
Also known as: Other specified impairment of electrophysiological functions | Normal electrooculogram | Normal EOG | Moderate impairment of electrooculogram | Moderate impairment of EOG
[EK92] Histiocytoses of uncertain malignant potential
Definition: Disorders characterised by abnormal proliferation of dendritic cells and macrophages. The proliferation may or may not be clonal and the prognosis is unpredictable.
Also known as: Histiocytoses of uncertain malignant potential | Systemic non-Langerhans cell histiocytosis | Faisalabad histiocytosis | Sea-blue histiocytosis | Sinus histiocytosis with massive lymphadenopathy
[QA53] Pressure as potential mode of injury without injury or harm
Definition: Pressure as a potential mode of injury, includes factors such as: body positioning, retractors, or other instruments with direct pressure, without documented injury or harm.
Also known as: Pressure as potential mode of injury without injury or harm | retractor usage too long or incorrect without documented injury or harm | patient kept in same position too long without documented injury or harm
Excludes: Pressure, as mode of injury or harm
[MA12.Y] Other specified clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
Also known as: Other specified clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system | Finding of other drugs of addictive potential in blood
=== GRAPH WALKS ===
--- Walk 1 ---
[CB40.Y] Other specified diseases of the respiratory system
--PARENT--> [CB40] Certain diseases of the respiratory system
--PARENT--> [12] Diseases of the respiratory system
--- Walk 2 ---
[CB40.Y] Other specified diseases of the respiratory system
--PARENT--> [CB40] Certain diseases of the respiratory system
--RELATED_TO--> [?] Alpha-1-antitrypsin deficiency
Def: Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterised by low serum leve...
--- Walk 3 ---
[LA75.1] Agenesis of lung
Def: This refers to the absence or rudimentary residua of an undeveloped lung....
--PARENT--> [LA75] Structural developmental anomalies of lungs
Def: Any condition caused by failure of the lungs to correctly develop during the antenatal period....
--CHILD--> [LA75.0] Accessory lobe of lung
Def: An extra lobe of lung beyond the 3 on the right and the 2 on the left...
--- Walk 4 ---
[LA75.1] Agenesis of lung
Def: This refers to the absence or rudimentary residua of an undeveloped lung....
--PARENT--> [LA75] Structural developmental anomalies of lungs
Def: Any condition caused by failure of the lungs to correctly develop during the antenatal period....
--PARENT--> [?] Structural developmental anomalies of the respiratory system
--- Walk 5 ---
[CA40.Z] Pneumonia, organism unspecified
--PARENT--> [CA40] Pneumonia
Def: A disease of the lungs, frequently but not always caused by an infection with bacteria, virus, fungus, or parasite. This disease is characterised by fever, chills, cough with sputum production, chest ...
--RELATED_TO--> [?] Pulmonary toxoplasmosis due to Toxoplasma gondii
Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...
--- Walk 6 ---
[CA40.Z] Pneumonia, organism unspecified
--PARENT--> [CA40] Pneumonia
Def: A disease of the lungs, frequently but not always caused by an infection with bacteria, virus, fungus, or parasite. This disease is characterised by fever, chills, cough with sputum production, chest ...
--CHILD--> [CA40.1] Viral pneumonia
Def: A disease of the pulmonary system, caused by an infection with a viral source. This disease is characterised by fever, lethargy, headache, myalgia, vomiting, or coughing. Transmission is by inhalation...
|
[
"[CB40.Y] Other specified diseases of the respiratory system\n --PARENT--> [CB40] Certain diseases of the respiratory system\n --PARENT--> [12] Diseases of the respiratory system",
"[CB40.Y] Other specified diseases of the respiratory system\n --PARENT--> [CB40] Certain diseases of the respiratory system\n --RELATED_TO--> [?] Alpha-1-antitrypsin deficiency\n Def: Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterised by low serum leve...",
"[LA75.1] Agenesis of lung\n Def: This refers to the absence or rudimentary residua of an undeveloped lung....\n --PARENT--> [LA75] Structural developmental anomalies of lungs\n Def: Any condition caused by failure of the lungs to correctly develop during the antenatal period....\n --CHILD--> [LA75.0] Accessory lobe of lung\n Def: An extra lobe of lung beyond the 3 on the right and the 2 on the left...",
"[LA75.1] Agenesis of lung\n Def: This refers to the absence or rudimentary residua of an undeveloped lung....\n --PARENT--> [LA75] Structural developmental anomalies of lungs\n Def: Any condition caused by failure of the lungs to correctly develop during the antenatal period....\n --PARENT--> [?] Structural developmental anomalies of the respiratory system",
"[CA40.Z] Pneumonia, organism unspecified\n --PARENT--> [CA40] Pneumonia\n Def: A disease of the lungs, frequently but not always caused by an infection with bacteria, virus, fungus, or parasite. This disease is characterised by fever, chills, cough with sputum production, chest ...\n --RELATED_TO--> [?] Pulmonary toxoplasmosis due to Toxoplasma gondii\n Def: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, o...",
"[CA40.Z] Pneumonia, organism unspecified\n --PARENT--> [CA40] Pneumonia\n Def: A disease of the lungs, frequently but not always caused by an infection with bacteria, virus, fungus, or parasite. This disease is characterised by fever, chills, cough with sputum production, chest ...\n --CHILD--> [CA40.1] Viral pneumonia\n Def: A disease of the pulmonary system, caused by an infection with a viral source. This disease is characterised by fever, lethargy, headache, myalgia, vomiting, or coughing. Transmission is by inhalation..."
] |
CB40.Y
|
Other specified diseases of the respiratory system
|
[
{
"from_icd11": "LA75.1",
"icd10_code": "Q333",
"icd10_title": "Agenesis of lung"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J189",
"icd10_title": "Pneumonia, unspecified organism"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J181",
"icd10_title": "Lobar pneumonia, unspecified organism"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J188",
"icd10_title": "Other pneumonia, unspecified organism"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J168",
"icd10_title": "Pneumonia due to other specified infectious organisms"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J180",
"icd10_title": "Bronchopneumonia, unspecified organism"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J17",
"icd10_title": "Pneumonia in diseases classified elsewhere"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J182",
"icd10_title": "Hypostatic pneumonia, unspecified organism"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J16",
"icd10_title": "Pneumonia due to other infectious organisms, not elsewhere classified"
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J171",
"icd10_title": ""
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J173",
"icd10_title": ""
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J178",
"icd10_title": ""
},
{
"from_icd11": "CA40.Z",
"icd10_code": "J18",
"icd10_title": "Pneumonia, unspecified organism"
},
{
"from_icd11": "CB41",
"icd10_code": "J9622",
"icd10_title": "Acute and chronic respiratory failure with hypercapnia"
},
{
"from_icd11": "CB41",
"icd10_code": "J9620",
"icd10_title": "Acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia"
}
] |
Q333
|
Agenesis of lung
|
The 39-year old patient presented to our emergency department two hours after having deliberately ingested approximately 30 g of Taxus baccata leaves and branches. He had collapsed in his residential home for psychiatric patients, clarified himself that he had ingested yew in a suicidal attempt, and was brought to our hospital by emergency medical services. His past medical history included schizophrenia and chronic hepatitis C. His premedication consisted of zolpidem, sertraline, olanzapine, clozapine, trazodone, oxazepam, and paliperidon. On arrival in the emergency department, he was somnolent (Glasgow coma scale 8), had a heart rate of 117/min, an oxygen saturation of 95%, and a body temperature of 36.9°C. A faint peripheral pulse was palpable but no blood pressure readings could be obtained. He was immediately transferred to ICU. Five minutes after arrival on the ICU, we started with cardiopulmonary resuscitation because of pulseless electric activity. During cardiopulmonary resuscitation, we administered adrenaline (4 mg), esketamine (250 mg), midazolam (5 mg), rocuronium (100 mg), magnesium (4.8 mmol), sodium bicarbonate 8.4% (100 ml), balanced crystalloid fluid , and noradrenaline (0.70 µg/kg/min). The initial electrocardiogram showed an irregular arrhythmia at a rate of 107/min with bizarre (non-typical bundle branch block) QRS prolongation >600 ms followed by irregular tachy- as well as bradyarrhythmias . Emergency echocardiography during cardiopulmonary resuscitation showed no pericardial effusion, and no relevant cardiac contractions. Defibrillation was ineffective . As there is no validated antidote for yew intoxication, we immediately performed extracorporeal life support via VA-ECMO, which was implanted during ongoing resuscitation with an automated chest compression system (LUCAS-2, Jolife AB, Lund Sweden). We used a 23 Fr drainage cannula in the left femoral vein and a 19 Fr return cannula in the right femoral artery with an antegrade perfusion catheter. Cardiopulmonary resuscitation with chest compressions was done for 39 minutes. In this period, we managed to perform tracheal intubation, central venous access, arterial line, emergency echocardiography, (ineffective) defibrillation, and implantation of VA-ECMO as a rescue therapy. Lactic acid levels rose to a maximum of 4.4 mmol/L 35 min after arrival on ICU and rapidly turned normal with start of VA-ECMO. It was not necessary to introduce a left ventricular assist device. The initial laboratory analysis showed a high white blood cell count of 25 G/l, a normal C-reactive protein of 0.8 mg/dl (normal range <5 mg/dl), and slightly elevated aspartate and alanine aminotransferase levels of 145 and 87 U/l, respectively (normal range < 50 U/l). We next conducted a gastroscopy, which revealed plenty of ingested yew leaves and branches . Gastric juice was removed together with the copious foliage (using endoscopic baskets), and activated charcoal was given via a nasogastric tube to reduce further resorption of toxins. Cardiac electrophysiology slowly recovered within the next hours, as shown in the sequential electrocardiograms . The initial pH of 7.372 decreased to a nadir of 7.276 after 10 hours and rapidly recovered to normal ranges thereafter. High-sensitivity cardiac troponin T levels reached a maximum of 161 pg/ml on day 2 (normal range <14 pg/ml), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) was slightly elevated to 134 pg/ml (normal range <100 pg/ml). Echocardiography on day 2 showed a left ventricular ejection fraction of 40%, no regional hypokinesis, and no pericardial effusion. Therefore, VA-ECMO support was stopped after 39 hours, and vascular surgeons removed cannulas. We liberated the patient from mechanical ventilation after seven days. He had no neurological deficit, and perfectly recalled what had happened. Neuronal specific enolase was within reference range, indicating that no relevant cerebral ischemia was present throughout treatment. On day 7, echocardiography showed full cardiac recovery with normal diameters of the cardiac chambers, normal left ventricular ejection fraction (60%), and normal right ventricular function (tricuspid annular plane systolic excursion 25 mm). The patient was discharged from ICU to psychiatry after 12 days and was dismissed from hospital after 23 days. Figure 1. Electrocardiogram after yew poisoning showing an irregular arrhythmia at a rate of 107/min with bizarre QRS prolongation. Figure 2. Ineffective defibrillation after ingestion of Taxus baccata (a) Irregular wide complex tachycardia terminating to arterial flutter without ventricular response. Seconds later, broad ventricular complexes appear that quickly degenerate into the irregular wide complex tachycardia. (b) Irregular wide complex tachycardia terminating to arterial flutter without ventricular response. (c-f) Ineffective defibrillation of wide complex tachycardia. Figure 3. Gastroscopy showing copious foliage of Taxus baccata. Figure 4. Sequential electrocardiograms 2 ½ h (a) 3 h (b), 18 h (c), and 22 h (d) after ingestion of Taxus baccata.
| 3.923828
| 0.972656
|
sec[1]/p[0]
|
en
| 0.999996
|
35942511
|
https://doi.org/10.1080/19336950.2022.2104886
|
[
"ventricular",
"irregular",
"emergency",
"resuscitation",
"cardiac",
"range",
"hours",
"taxus",
"baccata",
"cardiopulmonary"
] |
[
{
"code": "LA89.Z",
"title": "Functionally univentricular heart, unspecified"
},
{
"code": "BC45",
"title": "Cardiomegaly"
},
{
"code": "BA41.Z",
"title": "Acute myocardial infarction, unspecified"
},
{
"code": "BC46&XA7XU8",
"title": "Ventricular thrombosis"
},
{
"code": "BD1Z&XT5R",
"title": "Acute heart failure"
},
{
"code": "GA20.3",
"title": "Abnormal regularity of uterine bleeding"
},
{
"code": "MD11.Y",
"title": "Other specified abnormalities of breathing"
},
{
"code": "JB02.2",
"title": "Other uterine inertia"
},
{
"code": "GA20.1Z",
"title": "Abnormal frequency of uterine bleeding, unspecified"
},
{
"code": "GA22",
"title": "Excessive menstruation with irregular cycle"
}
] |
=== ICD-11 CODES FOUND ===
[LA89.Z] Functionally univentricular heart, unspecified
Also known as: Functionally univentricular heart, unspecified | Functionally univentricular heart | Univentricular cardiopathy | Single ventricle | univentricular heart
[BC45] Cardiomegaly
Also known as: Cardiomegaly | enlargement of heart | hypertrophic heart | heart hypertrophy | Cardiac hypertrophy
Includes: Left ventricular hyperplasia
[BA41.Z] Acute myocardial infarction, unspecified
Also known as: Acute myocardial infarction, unspecified | Acute myocardial infarction | cardiac attack | heart attack | acute cardiac infarction
[GA20.3] Abnormal regularity of uterine bleeding
Definition: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days.
Also known as: Abnormal regularity of uterine bleeding | Irregular menstrual bleeding | irregular cycle menstruation | irregular menses | irregular menstrual cycle
[MD11.Y] Other specified abnormalities of breathing
Also known as: Other specified abnormalities of breathing | Bradypnoea | Choking sensation | Hypoventilation | hypoventilation syndrome NOS
[JB02.2] Other uterine inertia
Definition: A condition affecting pregnant females that is idiopathic. This condition is characterised by the absence of effective uterine contractions during labour and abnormal relaxation of the uterus during labour. This condition leads to lack of labour progress or uterine haemorrhage.
Also known as: Other uterine inertia | atony of uterus NOS | Atony of uterus, during labour | hypotonic dysfunction of uterus complicating delivery | hypotonic labour
Includes: Atony of uterus, during labour
Excludes: atony of uterus, postpartum
[GA20.1Z] Abnormal frequency of uterine bleeding, unspecified
Also known as: Abnormal frequency of uterine bleeding, unspecified | Abnormal frequency of uterine bleeding | Other specified irregular menstruation | Latent menstruation | Membranous menstruation
[GA22] Excessive menstruation with irregular cycle
Also known as: Excessive menstruation with irregular cycle | excess menstruation with irregular cycle | excessive cycle with irregular cycle | Menometrorrhagia | Excessive or irregular menstruation
Includes: Menometrorrhagia
=== GRAPH WALKS ===
--- Walk 1 ---
[LA89.Z] Functionally univentricular heart, unspecified
--PARENT--> [LA89] Functionally univentricular heart
Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...
--PARENT--> [?] Structural developmental anomaly of heart or great vessels
Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....
--- Walk 2 ---
[LA89.Z] Functionally univentricular heart, unspecified
--PARENT--> [LA89] Functionally univentricular heart
Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...
--CHILD--> [LA89.0] Double inlet atrioventricular connection
Def: A congenital cardiovascular malformation with a univentricular atrioventricular connection wherein both atria connect to one ventricle either via two separate atrioventricular valves or a common atrio...
--- Walk 3 ---
[BC45] Cardiomegaly
--PARENT--> [?] Diseases of the myocardium or cardiac chambers
Def: This refers to diseases of a type of involuntary striated muscle found in the walls and histological foundation of the heart, with specific reference to the atrial and ventricular chambers, as well as...
--CHILD--> [BC40] Acquired atrial abnormality
Def: A postnatal pathological change in form or function of one or both atriums....
--- Walk 4 ---
[BC45] Cardiomegaly
--PARENT--> [?] Diseases of the myocardium or cardiac chambers
Def: This refers to diseases of a type of involuntary striated muscle found in the walls and histological foundation of the heart, with specific reference to the atrial and ventricular chambers, as well as...
--CHILD--> [BC40] Acquired atrial abnormality
Def: A postnatal pathological change in form or function of one or both atriums....
--- Walk 5 ---
[BA41.Z] Acute myocardial infarction, unspecified
--PARENT--> [BA41] Acute myocardial infarction
Def: The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Under these conditions any one o...
--EXCLUDES--> [?] Certain current complications following acute myocardial infarction
Def: Secondary conditions which may occur in the course after the heart attack. They include pericarditis, arrhythmia, cardiogenic shock, heart failure, ventricular rupture, ventricular aneurysm (with thro...
--- Walk 6 ---
[BA41.Z] Acute myocardial infarction, unspecified
--PARENT--> [BA41] Acute myocardial infarction
Def: The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Under these conditions any one o...
--EXCLUDES--> [?] Subsequent myocardial infarction
Def: Infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction...
|
[
"[LA89.Z] Functionally univentricular heart, unspecified\n --PARENT--> [LA89] Functionally univentricular heart\n Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...\n --PARENT--> [?] Structural developmental anomaly of heart or great vessels\n Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....",
"[LA89.Z] Functionally univentricular heart, unspecified\n --PARENT--> [LA89] Functionally univentricular heart\n Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...\n --CHILD--> [LA89.0] Double inlet atrioventricular connection\n Def: A congenital cardiovascular malformation with a univentricular atrioventricular connection wherein both atria connect to one ventricle either via two separate atrioventricular valves or a common atrio...",
"[BC45] Cardiomegaly\n --PARENT--> [?] Diseases of the myocardium or cardiac chambers\n Def: This refers to diseases of a type of involuntary striated muscle found in the walls and histological foundation of the heart, with specific reference to the atrial and ventricular chambers, as well as...\n --CHILD--> [BC40] Acquired atrial abnormality\n Def: A postnatal pathological change in form or function of one or both atriums....",
"[BC45] Cardiomegaly\n --PARENT--> [?] Diseases of the myocardium or cardiac chambers\n Def: This refers to diseases of a type of involuntary striated muscle found in the walls and histological foundation of the heart, with specific reference to the atrial and ventricular chambers, as well as...\n --CHILD--> [BC40] Acquired atrial abnormality\n Def: A postnatal pathological change in form or function of one or both atriums....",
"[BA41.Z] Acute myocardial infarction, unspecified\n --PARENT--> [BA41] Acute myocardial infarction\n Def: The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Under these conditions any one o...\n --EXCLUDES--> [?] Certain current complications following acute myocardial infarction\n Def: Secondary conditions which may occur in the course after the heart attack. They include pericarditis, arrhythmia, cardiogenic shock, heart failure, ventricular rupture, ventricular aneurysm (with thro...",
"[BA41.Z] Acute myocardial infarction, unspecified\n --PARENT--> [BA41] Acute myocardial infarction\n Def: The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Under these conditions any one o...\n --EXCLUDES--> [?] Subsequent myocardial infarction\n Def: Infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction..."
] |
LA89.Z
|
Functionally univentricular heart, unspecified
|
[
{
"from_icd11": "LA89.Z",
"icd10_code": "Q209",
"icd10_title": "Congenital malformation of cardiac chambers and connections, unspecified"
},
{
"from_icd11": "BC45",
"icd10_code": "I517",
"icd10_title": "Cardiomegaly"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I21A1",
"icd10_title": "Myocardial infarction type 2"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I21A9",
"icd10_title": "Other myocardial infarction type"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2109",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wall"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2119",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving other coronary artery of inferior wall"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2111",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving right coronary artery"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2102",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving left anterior descending coronary artery"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2129",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving other sites"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2121",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving left circumflex coronary artery"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I2101",
"icd10_title": "ST elevation (STEMI) myocardial infarction involving left main coronary artery"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I214",
"icd10_title": "Non-ST elevation (NSTEMI) myocardial infarction"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I213",
"icd10_title": "ST elevation (STEMI) myocardial infarction of unspecified site"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I219",
"icd10_title": "Acute myocardial infarction, unspecified"
},
{
"from_icd11": "BA41.Z",
"icd10_code": "I21",
"icd10_title": "Acute myocardial infarction"
}
] |
Q209
|
Congenital malformation of cardiac chambers and connections, unspecified
|
A 59-year-old woman was admitted to our institution on April 9, 2020 with a persistent cough and fatigue that had lasted for 2 months. She denied having a history of smoking or drinking, as well as any other medical or family history. Results of chest computer tomography (CT) suggested diffuse infiltration and interstitial edema on both of the lungs . A subsequent abdomen CT revealed a suspicious mass on her left adrenal gland, enlarged retroperitoneal lymph nodes, and multiple destruction of bones, including lumbar vertebrae, sacrum, and ilium. Because of the abnormally enlarged retroperitoneal lymph nodes, endoscope examinations, including gastroscopy and enteroscopy were scheduled. The gastroscopy findings suggested ulcerations in the lesser curvature of the stomach, which was finally identified as gastric adenocarcinoma with a poor differentiation degree . Immunohistochemistry outcomes were presented as: CDX-2 (positive), CEA (positive), Her-2 (2+), Ki-67 (60%), WT-1 (negative), CK5/6 (negative), CK7 (positive), β-catenin (positive), and CA199 (positive). Her-2 amplification positive was further identified with fluorescence in-situ hybridization. Based on these tests, the patient was ultimately diagnosed with gastric adenocarcinoma, with metastasis in the lungs, left adrenal gland, retroperitoneal lymph nodes, and multiple bones, which was identified as stage IV (T3N2M1 by the American Joint Committee on Cancer, 8th version). Because of the poor PS (PS = 3), we did not administer any cytotoxic drugs as front line treatment. Instead, monotherapy with trastuzumab at a dosage of 4 mg/kg the first week, followed by 2 mg/kg weekly was prescribed as a salvage treatment strategy. Simultaneously, next generation sequencing, including 50 tumor-related genes that utilized tissue and plasma samples was conducted to search for potential targets. After 2 weeks on trastuzumab and palliative care, the fatigue and poor appetite improved. However, the persistent cough and chest distress became even further aggravated. Repeated chest CT on May 12, 2020 revealed increased pleural effusion, and advanced to deteriorative interstitial edema in both of the lungs . Malignant pleural effusion was identified based on the findings from the malignant cells from pleural effusion . Although with pleural effusion drainage of 500 to 1000 mL daily, the cough or chest distress was not effectively relieved. Cough medications, including compound methoxyphenamine capsules, codeine phosphate, or montelukast showed no efficacy, On May 11, delayed next generation sequencing reported a 9.2-fold c-MET amplification in plasma levels and 4.4-fold in tumor tissue levels. As a salvage treatment, oral crizotinib was additionally administrated at a dosage of 250 mg twice a day from May 12, 2020. Simultaneously, weekly trastuzumab was still managed as before. Surprisingly, after only 2 days of the combination treatment, symptoms, including the persistent cough, and chest distress, which may have been caused by the lymphangitis carcinomatosa in lungs, were alleviated to a large degree. One week later, her PS improved from 4 to 2. We conducted an extra chest CT on May 19, 2020 to investigate the metastatic disease in lungs, although it was only 1 week after the previous chest CT was conducted. As a result, the results from the chest CT showed that lymphangitis carcinomatosa had dissipated by a large degree, not to mention an apparent reduction in pleural effusion, which should not have seen improvement from mere punctures of pleural effusions . Based on the superior efficacy of the combinational regimen and improvement in PS, we recommended standard chemotherapeutic regimens, including FOLFOX (Oxaliplatin plus fluorouracil) or SOX (Oxaliplatin plus S-1) as sequential treatment. However, the patient refused any cytotoxic drugs, and discharged then. At that point she had completed 2 months of the combined trastuzumab and crizotinib treatment at the clinic. The best response status was evaluated as a partial response, according to the criteria of the Response Evaluation Criteria in Solid Tumors (version 1.1). No adverse events, including nausea, vomiting, diarrhea, or hypertension were observed during the following 2 months, according to the criteria of National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. On July 9, 2020, the patient was admitted to our hospital again because of an aggravated cough. A chest CT revealed the exacerbation of deteriorative interstitial edema . However, other lesions, including the left adrenal gland, enlarged retroperitoneal lymph nodes, and multiple destruction of bone were evaluated as a stable disease. Based on the image results, the patient was evaluated as having a progressive disease then. Although with active and supportive care, including draining pleural effusion, the symptoms from the chest distress did not improve. The patient died of respiratory failure in August 2020. The variations in tumor markers, including CEA, CA125, and CA19-9 during the whole treatment process were presented in Figure 3 .
| 4.039063
| 0.974121
|
sec[1]/p[0]
|
en
| 0.999998
|
34516491
|
https://doi.org/10.1097/MD.0000000000027017
|
[
"chest",
"including",
"pleural",
"cough",
"effusion",
"lungs",
"that",
"retroperitoneal",
"lymph",
"nodes"
] |
[
{
"code": "CB7Z",
"title": "Diseases of the respiratory system, unspecified"
},
{
"code": "CB27",
"title": "Pleural effusion"
},
{
"code": "CA44",
"title": "Pyothorax"
},
{
"code": "MD30.Z",
"title": "Chest pain, unspecified"
},
{
"code": "NA80.Y&XJ1C6",
"title": "Thoracic haematoma"
},
{
"code": "7A24",
"title": "Hypersomnia due to a medication or substance"
},
{
"code": "9D90",
"title": "Vision impairment including blindness"
},
{
"code": "NE61",
"title": "Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified"
},
{
"code": "3A50.02",
"title": "Haemoglobin H disease (– α/– – included)"
},
{
"code": "LA8B.Z",
"title": "Congenital anomaly of great arteries including arterial duct, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[CB7Z] Diseases of the respiratory system, unspecified
Also known as: Diseases of the respiratory system, unspecified | disorder of respiratory system | respiratory disease NOS | respiratory tract disease | respiratory disorder NOS
[CB27] Pleural effusion
Definition: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces.
Also known as: Pleural effusion | PE - [pleural effusion] | Pleurisy with effusion | pleurisy with effusion NOS | pleural effusion with transudate
Includes: Pleurisy with effusion
Excludes: Tuberculosis of the respiratory system | Chylous effusion | Pleurisy
[CA44] Pyothorax
Definition: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or penetrating trauma with a secondary infection.
Also known as: Pyothorax | empyema | pyopneumothorax | Pyothorax with fistula | empyema with fistula
Includes: empyema | pyopneumothorax
Excludes: due to tuberculosis
[MD30.Z] Chest pain, unspecified
Also known as: Chest pain, unspecified | Pain in throat or chest | chest pain NOS | pain in chest | chest pressure
[7A24] Hypersomnia due to a medication or substance
Definition: Hypersomnia due to a medication or substance is characterised by excessive nocturnal sleep, daytime sleepiness, or excessive napping that is attributable to the sedating effects of medications, alcohol, or other psychoactive substances, including withdrawal syndromes (e.g., from stimulants) and is sufficiently severe to constitute an independent focus of clinical attention.
Note: A definitive diagnosis requires use of polysomnography and multiple sleep latency test (MSLT) to rule out other hype
Also known as: Hypersomnia due to a medication or substance | Hypersomnia due to substances including medications | Hypersomnolence due to substances including medications
Includes: Hypersomnia due to substances including medications
[9D90] Vision impairment including blindness
Definition: !markdown
The table below gives a classification of severity of vision impairment based on visual acuity.
For epidemiological studies, it is recommended to collect the following information on visual acuity for each eye, for both eyes open and for distance and near.
a) Uncorrected visual acuity
b) Presenting visual acuity
c) Best corrected visual acuity
Blindness is also categorized according to the degree of constriction of the central visual field in the better eye to less than 10
Also known as: Vision impairment including blindness
[NE61] Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified
Also known as: Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified | Harmful effects of or exposure to noxious substances chiefly nonmedicinal as to source, alcohols | alcohol poisoning | alcohol toxicity | Harmful effects of or exposure to noxious substances chiefly nonmedicinal as to source, Ethanol
Excludes: corrosions | Bacterial foodborne intoxications
[3A50.02] Haemoglobin H disease (– α/– – included)
Definition: Haemoglobin H (HbH) disease is a moderate to severe form of alpha-thalassemia characterised by pronounced microcytic hypochromic haemolytic anaemia.
Also known as: Haemoglobin H disease (– α/– – included) | alpha - /- - or mutational forms of alpha-thalassaemia | Alpha thalassaemia intermedia
[LA8B.Z] Congenital anomaly of great arteries including arterial duct, unspecified
Also known as: Congenital anomaly of great arteries including arterial duct, unspecified | Congenital anomaly of great arteries including arterial duct
=== GRAPH WALKS ===
--- Walk 1 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--CHILD--> [?] Certain lower respiratory tract diseases
Def: This group refers to diseases of airways that forms the connection between the outside world and the terminal respiratory unit. Intrapulmonary airways are divided into three major groups; bronchi, mem...
--- Walk 2 ---
[CB7Z] Diseases of the respiratory system, unspecified
--PARENT--> [12] Diseases of the respiratory system
--CHILD--> [?] Upper respiratory tract disorders
Def: This group of disorders refers to diseases of the upper airways (upper respiratory tract). The upper airways anatomically are complicated structures which extend from the airway openings at the nares ...
--- Walk 3 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Tuberculosis of the respiratory system
Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M....
--CHILD--> [?] Respiratory tuberculosis, not confirmed
Def: A disease of the respiratory tract, caused by an infection with the bacteria Mycobacterium tuberculosis, which has not been confirmed. This disease is characterised by a chronic cough, and sputum prod...
--- Walk 4 ---
[CB27] Pleural effusion
Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....
--EXCLUDES--> [?] Tuberculosis of the respiratory system
Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M....
--CHILD--> [?] Respiratory tuberculosis, confirmed
Def: A disease of the respiratory tract, caused by an infection with the bacteria Mycobacterium tuberculosis, which has been confirmed by laboratory testing. This disease is characterised by chronic cough,...
--- Walk 5 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...
--- Walk 6 ---
[CA44] Pyothorax
Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...
--EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation
Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...
--PARENT--> [?] Tuberculosis of the respiratory system
Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M....
|
[
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --CHILD--> [?] Certain lower respiratory tract diseases\n Def: This group refers to diseases of airways that forms the connection between the outside world and the terminal respiratory unit. Intrapulmonary airways are divided into three major groups; bronchi, mem...",
"[CB7Z] Diseases of the respiratory system, unspecified\n --PARENT--> [12] Diseases of the respiratory system\n --CHILD--> [?] Upper respiratory tract disorders\n Def: This group of disorders refers to diseases of the upper airways (upper respiratory tract). The upper airways anatomically are complicated structures which extend from the airway openings at the nares ...",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Tuberculosis of the respiratory system\n Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M....\n --CHILD--> [?] Respiratory tuberculosis, not confirmed\n Def: A disease of the respiratory tract, caused by an infection with the bacteria Mycobacterium tuberculosis, which has not been confirmed. This disease is characterised by a chronic cough, and sputum prod...",
"[CB27] Pleural effusion\n Def: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces....\n --EXCLUDES--> [?] Tuberculosis of the respiratory system\n Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M....\n --CHILD--> [?] Respiratory tuberculosis, confirmed\n Def: A disease of the respiratory tract, caused by an infection with the bacteria Mycobacterium tuberculosis, which has been confirmed by laboratory testing. This disease is characterised by chronic cough,...",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --EXCLUDES--> [?] Primary respiratory tuberculosis without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease of the respiratory caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. This diagnosis is without mention of ba...",
"[CA44] Pyothorax\n Def: Suppurative inflammation of the pleural space, typically due to acute bacterial infection. It can occur as a complication of pneumonia, thoracotomy, abscesses (lung, hepatic, or subdiaphragmatic), or ...\n --EXCLUDES--> [?] Tuberculous pleurisy, without mention of bacteriological or histological confirmation\n Def: This is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis, with an inflammation of the pleura. This diagnosis is with...\n --PARENT--> [?] Tuberculosis of the respiratory system\n Def: This is a progressive or chronic disease resulting from infection with the bacterium Mycobacterium tuberculosis or other bacteria in the M. tuberculosis complex: M. bovis, M. africanum, M. canetti, M...."
] |
CB7Z
|
Diseases of the respiratory system, unspecified
|
[
{
"from_icd11": "CB7Z",
"icd10_code": "J989",
"icd10_title": "Respiratory disorder, unspecified"
},
{
"from_icd11": "CB7Z",
"icd10_code": "X",
"icd10_title": ""
},
{
"from_icd11": "CB7Z",
"icd10_code": "J09-J18",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J910",
"icd10_title": "Malignant pleural effusion"
},
{
"from_icd11": "CB27",
"icd10_code": "J918",
"icd10_title": "Pleural effusion in other conditions classified elsewhere"
},
{
"from_icd11": "CB27",
"icd10_code": "J90",
"icd10_title": "Pleural effusion, not elsewhere classified"
},
{
"from_icd11": "CB27",
"icd10_code": "J90-J94",
"icd10_title": ""
},
{
"from_icd11": "CB27",
"icd10_code": "J91",
"icd10_title": "Pleural effusion in conditions classified elsewhere"
},
{
"from_icd11": "CA44",
"icd10_code": "J869",
"icd10_title": "Pyothorax without fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J860",
"icd10_title": "Pyothorax with fistula"
},
{
"from_icd11": "CA44",
"icd10_code": "J85-J86",
"icd10_title": ""
},
{
"from_icd11": "CA44",
"icd10_code": "J86",
"icd10_title": "Pyothorax"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0781",
"icd10_title": "Pleurodynia"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R0782",
"icd10_title": "Intercostal pain"
},
{
"from_icd11": "MD30.Z",
"icd10_code": "R079",
"icd10_title": "Chest pain, unspecified"
}
] |
J989
|
Respiratory disorder, unspecified
|
On arrival, she was found to have a temperature of 40.9°C, heart rate of 184 beats/min, respiratory rate of 36 breaths/min, and blood pressure of 53/26 mm Hg. Physical exam revealed a toxic-appearing toddler. She was tachycardic and tachypneic, with delayed capillary refill. Her abdominal exam on admission revealed no organomegaly. Physical exam was otherwise noncontributory. Laboratory investigations revealed a pH of 7.1; PCO 2 of 35 mm Hg; PO 2 of 52 mm Hg; HCO 3 of 11 mg/dL; prothrombin time of 37.8 s; international normalized ratio of 3.8; activated partial prothrombin time of 101.4 s; total leukocyte count of 1900/mm 3 , with 10% banded neutrophils and 25% segmented neutrophils; hemoglobin of 10.8 g/dL; and platelet count of 67 000/mm 3 . Lumbar puncture was performed and revealed a white blood cell count of 1 per mm 3 , red blood cell count of 3 per mm 3 , glucose 108 mg/dL, and protein 83 mg/dL. Blood, urine, and CSF cultures were sent, and she was started on broad spectrum antibiotics with vancomycin and ceftriaxone. She was admitted to the pediatric intensive care unit for management of septic shock, disseminated intravascular coagulopathy, and multiple organ dysfunction syndrome. The blood culture from admission became positive after 8 hours of growth, which was identified as S pneumoniae that was sensitive to penicillin and ceftriaxone, with a minimum inhibitory concentration of less than 0.03 µg/mL. An immunological workup revealed a normal antibody response to childhood vaccinations, including diphtheria, tetanus, and pneumococcus; IgM was 82 mg/dL, IgG was 986 mg/dL, and IgA was 106 mg/dL; total complement (CH50) was 63 U/mL, and alternative complement pathway (AH50) was 65%, all of which were within normal limits. S pneumoniae IgG to 14 serotypes from ARUP laboratories demonstrated >1.3 µg/mL for 10 of the 14 serotypes, which is consistent with an adequate vaccination response. Newborn screen was negative for sickle cell disease, and there was no family history of sickle cell disease. Vancomycin was discontinued after reviewing the sensitivities and documentation of sterile cerebrospinal fluid. She was initially hypotensive despite being placed on vasoactive medications for treatment of refractory shock. On hospital day 4, she developed dry gangrene of the distal phalanges . On hospital day 8, she remained febrile after resolution of septic shock. Subsequent physical exam revealed a tender mass 3 cm below the left costal margin, which prompted an evaluation. A computed tomography (CT) scan of the abdomen with contrast obtained on hospital day 9 revealed 3 rim-enhancing splenic abscesses measuring 3.4, 2.4, and 1.4 cm . Our pediatric infectious disease service was consulted for assistance with the management of splenic abscesses, and they suggested consulting pediatric surgery for surgical intervention in addition to antibiotic therapy. Transthoracic echocardiogram on day 11 of hospitalization did not reveal intracardiac vegetations. MRI of the brain was only significant for mild atrophy and did not reveal any brain abscesses. Pediatric surgery and interventional radiology were consulted, and both recommended medical management to avoid potential complications—that is, bleeding and spread of infection into the pleural space. Clindamycin was added because of its penetration into abscess fluid, although susceptibilities were not performed by the microbiology laboratory. The pathogen isolated from the initial blood culture was sent to the Nevada State Public Health Laboratory for serotyping, which revealed the presence of serotype 22F/A. After discussion with Hematology, an evaluation for an underlying coagulopathy was not performed because her coagulation studies normalized after treatment of her infectious process. All repeat blood cultures revealed no growth of bacterial pathogens. The patient’s splenic abscesses were monitored with weekly ultrasounds. She completed a 14-day course of intravenous ceftriaxone for treatment of S pneumoniae bacteremia. Antibiotics were narrowed to intravenous penicillin G potassium to complete her treatment course for her splenic abscesses. Repeat CT scan of the abdomen on hospital day 41 revealed a decreased size of the splenic abscesses, with the largest collection measuring 1.5 cm; resolution of the smallest collection; and lack of rim enhancement . The patient demonstrated an allergy to penicillin G and cephalexin at the end of her treatment course. Therefore, it was decided to change to clindamycin even though there was no documented susceptibility, and this was continued for an additional 2 weeks. Repeat ultrasound 2 weeks after discharge demonstrated resolution of all but 1 splenic abscess, which was now 0.9 cm. Antibiotics were discontinued at that time. Her antibiotic course included a total of 6 weeks of IV antibiotics and 2 additional weeks of oral antibiotics. The remaining abscess had resolved as of her 1-month follow-up visit. She underwent debridement after autoamputation of her necrotic digits. Currently, she remains afebrile as of her 6-month follow-up visit.
| 3.939453
| 0.976074
|
sec[1]/p[1]
|
en
| 0.999996
|
27006958
|
https://doi.org/10.1177/2324709616636398
|
[
"blood",
"which",
"splenic",
"abscesses",
"antibiotics",
"exam",
"count",
"cell",
"pediatric",
"course"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "BD50.41",
"title": "Abdominal aortic aneurysm with rupture"
},
{
"code": "EK91",
"title": "Dermatoses which may presage cutaneous lymphoma"
},
{
"code": "MH12.1",
"title": "Death occurring less than 24 hours from onset of symptoms, not otherwise explained"
},
{
"code": "8A44.3",
"title": "Certain specified leukodystrophies"
},
{
"code": "3B8Z",
"title": "Diseases of spleen, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[BD50.41] Abdominal aortic aneurysm with rupture
Also known as: Abdominal aortic aneurysm with rupture | abdominal aorta aneurysm rupture | abdominal aorta aneurysm ruptured | abdominal aortic aneurysm which has ruptured | ruptured AAA
[EK91] Dermatoses which may presage cutaneous lymphoma
Definition: Dermatoses which may represent the earliest stages of cutaneous lymphoma but where it is not possible to confirm their neoplastic nature.
Also known as: Dermatoses which may presage cutaneous lymphoma
[MH12.1] Death occurring less than 24 hours from onset of symptoms, not otherwise explained
Also known as: Death occurring less than 24 hours from onset of symptoms, not otherwise explained | died without sign of disease | Death known not to be violent or instantaneous for which no cause can be discovered | death known not to be violent or instantaneous, cause unknown | Death without sign of disease
Includes: Death known not to be violent or instantaneous for which no cause can be discovered | Death without sign of disease
[8A44.3] Certain specified leukodystrophies
Also known as: Certain specified leukodystrophies | CACH syndrome | Vanishing white matter disease | Childhood ataxia with central nervous system hypomyelination | Congenital or early infantile CACH syndrome
[3B8Z] Diseases of spleen, unspecified
Also known as: Diseases of spleen, unspecified | splenic disease | splenopathy
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Diseases of the immune system
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--EXCLUDES--> [?] Recurrent or persistent glomerular haematuria
Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.1] Finding of cocaine in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Diseases of the immune system",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --EXCLUDES--> [?] Recurrent or persistent glomerular haematuria\n Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.1] Finding of cocaine in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
A 0-day-old female baby was referred to our department due to abdominal distention. During the prenatal stage, the baby was diagnosed with intestinal atresia based on the intestinal loop dilatation findings found via maternal ultrasonography. She was delivered vaginally at full term weighing 3.5 kg. X-ray examination revealed dextrocardia, left-sided liver, and shifting of the nasogastric tube to the right side . Abdominal ultrasonography test revealed multiple dilated intestinal loop and situs inversus . The baby was diagnosed as having intestinal atresia with situs inversus and underwent emergency exploratory laparotomy after adequate resuscitation on the day of birth. A transverse incision on the upper abdomen was performed, revealing completely reversed left and right abdominal organs. The origin of the jejunum was on the left side accompanied with tubular intestinal duplication. The origin of the duplicated intestine was at the dorsal area of the pancreatic head. The tubular intestinal duplication was on the mesenteric side with a length of 40 cm. There were two points of type Шa ileal atresia at the intervals of 5 cm each. The distal side of the ileum and the entire colon was collapsed . Initially, we tried to resect the duplicated intestine with the accompanying jejunum. However, the proximal end point of the duplicated intestine was on the dorsal area of the pancreatic head and was not dissected completely even after Kocher’s maneuver. In addition, it was unclear whether the ampulla of Vater was on the true lumen of the jejunum or duplicated intestine. Therefore, the duplicated intestine with the length of 3 cm was spared and anastomosed with the true lumen of the jejunum, and the residual duplicated intestine with the accompanying jejunum was resected. The duplicated intestine was transected at 3 cm from the lower border of the pancreatic head, and the true jejunum was transected at 5 cm from the origin. The absence of the ampulla of Vater in the observation range of both lumens was confirmed. Small holes were made on the each wall of the duplicated intestine and true jejunum, and functional-side-to-side anastomosis was achieved with a 45-mm Endo-GIA™ camel load (Medtronic, Minneapolis, MN, USA). The insertion point was closed with a 5–0 absorbable suture. The ileum was transected at the distal side of the atresia point, and the mesenteric vessels were clamped and resected. The end-to-end anastomosis was performed with a 5–0 absorbable suture. A 5-Fr tube was passed through before suture completion as a transanastomotic tube . The abdominal cavity was irrigated, and a drain was inserted into the Douglas’s pouch via the right lateral region; then, the wound was closed. The patient was extubated on day 6 postoperation. Gastrointestinal series on day 11 postoperation revealed no contrast agent leakage; however, a contrast agent pathway from the oral side of the side-to-side anastomosis to the stomach’s dorsal area was observed . In addition, an abdominal computed tomogram revealed a luminal structure on the stomach’s dorsal area, which was compatible with the duplicated alimentary tract . It was speculated that the oral end of duplication is the stomach and the contrast agent flew into this remaining area. Enteral nutrition was initiated and established safely, and the patient was discharged at 2 months postoperatively. She has been received H 2 blocker, because there has been a concern about gastrointestinal hemorrhage caused by ectopic stomach mucosa in the residual duplicated tract. She has been under periodical medical surveillance without gastrointestinal complications such as inflammation or hemorrhage and will undergo resection of residual duplication. Fig. 1 Preoperative imaging studies . A X-ray film revealed dextrocardia, opacity of the liver on the left side, and shifting of the nasogastric tube to the right side. B Abdominal ultrasonogram showed remarkable dilatation of the intestine Fig. 2 Intraoperative findings. A The tubular intestinal duplication was found on the mesenteric side with a length of 40 cm (arrow head). Two points of type Шa ileal atresia at intervals of 5 cm were also found (arrow). B Schema of the intraoperative findings Fig. 3 Findings of reconstruction. A Functional side-to-side anastomosis between the duplicated jejunum and true lumen of the jejunum was achieved with the Endo-GIA™ camel load (Medtronic, Minneapolis, MN, USA) (arrow head), and end-to-back anastomosis between the jejunum and ileum was achieved with absorbable suture (arrow). B Schema of reconstruction. Fig. 4 Postoperative imaging studies. A Postoperative gastrointestinal film showed a contrast agent pathway from the oral side of the side-to-side anastomosis to the dorsal area of the stomach, which was considered as remaining duplication (arrow). A 5-Fr tube was placed near the distal area of the anastomosis. B An abdominal computed tomogram revealed a luminal structure on the stomach’s dorsal area, which was compatible with the duplicated alimentary tract (arrow head). The stomach is located under the liver (arrow)
| 3.988281
| 0.976563
|
sec[1]/p[0]
|
en
| 0.999997
|
37556040
|
https://doi.org/10.1186/s40792-023-01728-2
|
[
"side",
"duplicated",
"jejunum",
"intestine",
"area",
"abdominal",
"intestinal",
"anastomosis",
"stomach",
"arrow"
] |
[
{
"code": "NE60",
"title": "Harmful effects of drugs, medicaments or biological substances, not elsewhere classified"
},
{
"code": "LA8B.2Y",
"title": "Other specified congenital anomaly of aorta or its branches"
},
{
"code": "LB9A.6",
"title": "Split foot"
},
{
"code": "LA80.0",
"title": "Laevocardia"
},
{
"code": "LA80.1",
"title": "Dextrocardia"
},
{
"code": "LD41.Z",
"title": "Duplications of the autosomes, unspecified"
},
{
"code": "LD41.Y",
"title": "Other specified duplications of the autosomes"
},
{
"code": "LD41.0Z",
"title": "Duplications of chromosome 1, unspecified"
},
{
"code": "LD41.1Z",
"title": "Duplications of chromosome 2, unspecified"
},
{
"code": "LD41.2Z",
"title": "Duplications of chromosome 3, unspecified"
}
] |
=== ICD-11 CODES FOUND ===
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
Also known as: Harmful effects of drugs, medicaments or biological substances, not elsewhere classified | drugs, medicaments or biological substances, toxicity not elsewhere classified | adverse drug effects | drug reaction NOS | drug allergy NOS
Excludes: Alcohol intoxication | pathological drug intoxication | hypersensitivity reaction to correctly administered drug
[LA8B.2Y] Other specified congenital anomaly of aorta or its branches
Also known as: Other specified congenital anomaly of aorta or its branches | Congenital anomaly of ascending aorta | Hypoplasia of ascending aorta | Congenital ascending aorta aneurysm or dilation | congenital ascending aortic aneurysm or dilation
[LB9A.6] Split foot
Definition: A condition caused by malformation of the foot during the antenatal period. This condition is characterised by a deep median cleft of the foot due to the absence of the central rays.
Also known as: Split foot | lobster claw foot | split foot, unspecified side | cleft of foot | Split foot, unilateral
[LA80.0] Laevocardia
Definition: A congenital cardiovascular finding in which the heart is predominantly to the left of the thoracic midline.
Also known as: Laevocardia | Left-sided heart | Levocardia
[LA80.1] Dextrocardia
Definition: A congenital cardiovascular malformation in which the heart is predominantly to the right of the thoracic midline. This is independent of the orientation of the cardiac apex.
Also known as: Dextrocardia | heart in right chest | right-sided heart | congenital dextrocardia of heart | transposition of heart
Excludes: Isomerism of left atrial appendages | Isomerism of right atrial appendages | Total mirror imagery
[LD41.Z] Duplications of the autosomes, unspecified
Also known as: Duplications of the autosomes, unspecified | Duplications of the autosomes
[LD41.Y] Other specified duplications of the autosomes
Also known as: Other specified duplications of the autosomes
[LD41.0Z] Duplications of chromosome 1, unspecified
Also known as: Duplications of chromosome 1, unspecified | Duplications of chromosome 1
[LD41.1Z] Duplications of chromosome 2, unspecified
Also known as: Duplications of chromosome 2, unspecified | Duplications of chromosome 2
[LD41.2Z] Duplications of chromosome 3, unspecified
Also known as: Duplications of chromosome 3, unspecified | Duplications of chromosome 3
=== GRAPH WALKS ===
--- Walk 1 ---
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
--EXCLUDES--> [?] Alcohol intoxication
Def: Alcohol intoxication is a clinically significant transient condition that develops during or shortly after the consumption of alcohol that is characterised by disturbances in consciousness, cognition,...
--EXCLUDES--> [?] Possession trance disorder
Def: Possession trance disorder is characterised by trance states in which there is a marked alteration in the individual’s state of consciousness and the individual’s customary sense of personal identity ...
--- Walk 2 ---
[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
--EXCLUDES--> [?] Disorders due to substance use or addictive behaviours
Def: Disorders due to substance use and addictive behaviours are mental and behavioural disorders that develop as a result of the use of predominantly psychoactive substances, including medications, or spe...
--CHILD--> [?] Disorders due to addictive behaviours
Def: Disorders due to addictive behaviours are recognizable and clinically significant syndromes associated with distress or interference with personal functions that develop as a result of repetitive rewa...
--- Walk 3 ---
[LA8B.2Y] Other specified congenital anomaly of aorta or its branches
--PARENT--> [LA8B.2] Congenital anomaly of aorta or its branches
Def: A congenital cardiovascular malformation of the aorta and/or its branches....
--CHILD--> [LA8B.22] Interrupted aortic arch
Def: A congenital cardiovascular malformation in which there is an absence of luminal continuity between the ascending and descending aorta.
Additional information: this includes luminal atresia with disc...
--- Walk 4 ---
[LA8B.2Y] Other specified congenital anomaly of aorta or its branches
--PARENT--> [LA8B.2] Congenital anomaly of aorta or its branches
Def: A congenital cardiovascular malformation of the aorta and/or its branches....
--CHILD--> [LA8B.21] Coarctation of aorta
Def: A congenital cardiovascular malformation in which there is a discrete luminal narrowing of the junction between the aortic arch and the descending aorta.
Additional information: 'Coarctation of the a...
--- Walk 5 ---
[LB9A.6] Split foot
Def: A condition caused by malformation of the foot during the antenatal period. This condition is characterised by a deep median cleft of the foot due to the absence of the central rays....
--PARENT--> [LB9A] Reduction defects of lower limb
Def: Any condition caused by the failure of a lower limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....
--CHILD--> [LB9A.0] Amelia of lower limb
--- Walk 6 ---
[LB9A.6] Split foot
Def: A condition caused by malformation of the foot during the antenatal period. This condition is characterised by a deep median cleft of the foot due to the absence of the central rays....
--PARENT--> [LB9A] Reduction defects of lower limb
Def: Any condition caused by the failure of a lower limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....
--CHILD--> [LB9A.0] Amelia of lower limb
|
[
"[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified\n --EXCLUDES--> [?] Alcohol intoxication\n Def: Alcohol intoxication is a clinically significant transient condition that develops during or shortly after the consumption of alcohol that is characterised by disturbances in consciousness, cognition,...\n --EXCLUDES--> [?] Possession trance disorder\n Def: Possession trance disorder is characterised by trance states in which there is a marked alteration in the individual’s state of consciousness and the individual’s customary sense of personal identity ...",
"[NE60] Harmful effects of drugs, medicaments or biological substances, not elsewhere classified\n --EXCLUDES--> [?] Disorders due to substance use or addictive behaviours\n Def: Disorders due to substance use and addictive behaviours are mental and behavioural disorders that develop as a result of the use of predominantly psychoactive substances, including medications, or spe...\n --CHILD--> [?] Disorders due to addictive behaviours\n Def: Disorders due to addictive behaviours are recognizable and clinically significant syndromes associated with distress or interference with personal functions that develop as a result of repetitive rewa...",
"[LA8B.2Y] Other specified congenital anomaly of aorta or its branches\n --PARENT--> [LA8B.2] Congenital anomaly of aorta or its branches\n Def: A congenital cardiovascular malformation of the aorta and/or its branches....\n --CHILD--> [LA8B.22] Interrupted aortic arch\n Def: A congenital cardiovascular malformation in which there is an absence of luminal continuity between the ascending and descending aorta.\n\nAdditional information: this includes luminal atresia with disc...",
"[LA8B.2Y] Other specified congenital anomaly of aorta or its branches\n --PARENT--> [LA8B.2] Congenital anomaly of aorta or its branches\n Def: A congenital cardiovascular malformation of the aorta and/or its branches....\n --CHILD--> [LA8B.21] Coarctation of aorta\n Def: A congenital cardiovascular malformation in which there is a discrete luminal narrowing of the junction between the aortic arch and the descending aorta.\n\nAdditional information: 'Coarctation of the a...",
"[LB9A.6] Split foot\n Def: A condition caused by malformation of the foot during the antenatal period. This condition is characterised by a deep median cleft of the foot due to the absence of the central rays....\n --PARENT--> [LB9A] Reduction defects of lower limb\n Def: Any condition caused by the failure of a lower limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....\n --CHILD--> [LB9A.0] Amelia of lower limb",
"[LB9A.6] Split foot\n Def: A condition caused by malformation of the foot during the antenatal period. This condition is characterised by a deep median cleft of the foot due to the absence of the central rays....\n --PARENT--> [LB9A] Reduction defects of lower limb\n Def: Any condition caused by the failure of a lower limb to correctly develop during the antenatal period. These conditions are characterised by reduction in size or absence of the limb....\n --CHILD--> [LB9A.0] Amelia of lower limb"
] |
NE60
|
Harmful effects of drugs, medicaments or biological substances, not elsewhere classified
|
[
{
"from_icd11": "NE60",
"icd10_code": "T50A95A",
"icd10_title": "Adverse effect of other bacterial vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z15A",
"icd10_title": "Adverse effect of immunoglobulin, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50Z95A",
"icd10_title": "Adverse effect of other vaccines and biological substances, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A95S",
"icd10_title": "Adverse effect of other bacterial vaccines, sequela"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B95A",
"icd10_title": "Adverse effect of other viral vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A25A",
"icd10_title": "Adverse effect of mixed bacterial vaccines without a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A91A",
"icd10_title": "Poisoning by other bacterial vaccines, accidental (unintentional), initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T498X5A",
"icd10_title": "Adverse effect of other topical agents, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48905A",
"icd10_title": "Adverse effect of unspecified agents primarily acting on the respiratory system, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T48995A",
"icd10_title": "Adverse effect of other agents primarily acting on the respiratory system, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50A15A",
"icd10_title": "Adverse effect of pertussis vaccine, including combinations with a pertussis component, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T50B15A",
"icd10_title": "Adverse effect of smallpox vaccines, initial encounter"
},
{
"from_icd11": "NE60",
"icd10_code": "T416X3A",
"icd10_title": ""
},
{
"from_icd11": "NE60",
"icd10_code": "T419X3A",
"icd10_title": ""
},
{
"from_icd11": "NE60",
"icd10_code": "T418X2A",
"icd10_title": ""
}
] |
T50A95A
|
Adverse effect of other bacterial vaccines, initial encounter
|
A 50-year-old man was admitted to our hospital with acute-onset dysarthria. He presented febrile, with respiratory distress and lethargy, and performed poorly in the right hand alternating movement test. After finding an obvious cardiac murmur, he was transferred to the cardiology department, from the neurology department. Physical examination revealed a blood pressure of 130/90 mm Hg, and heart rate of 116 beats per minute. Cardiac examination revealed that the apex beat was located in the sixth intercostal space, 1.5 cm outside the midclavicular line. Cardiac auscultation revealed a grade 4/6 systolic murmur that was most prominent at the apex. Electrocardiography revealed sinus tachycardia without evidence of ischemia, and serum levels of troponin T, creatine kinase (CK), and CK-myoglobin (CK-MB) were normal; however, N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) levels were increased . The leukocyte count was 10620/mm 3 , with neutrophils at 10 350/mm 3 . The erythrocyte sediment rate was 68 mm/h, and blood culture was positive for group A β-hemolytic streptococcus . Transthoracic and transesophageal echocardiography revealed rupture of the mitral chordae tendineae, perforation of the leaflet, mitral vegetation measuring 40 × 30 mm, and severe regurgitation . The left ventricular chamber was enlarged (left ventricular end-diastolic diameter: 64 mm; left ventricular end-systolic diameter: 45 mm), and the pulmonary artery was dilated (diameter: 33 mm; systolic pressure: 94 mm Hg). Cranial MRI revealed high signal intensity in the left hemisphere, indicating cerebral infarction . Abdominal ultrasound showed multiple echo-free areas in the spleen that suggested splenic abscess formation , and multiple blood cultures confirmed the presence of group A β-hemolytic Streptococcus . A diagnosis of left-sided native valve IE was made based on the modified Duke criteria, and the patient’s body temperature was well-controlled by ceftriaxone and vancomycin antibiotic therapy. However, 12 days after presentation, he complained of severe retrosternal chest pain radiating to his back, with ECG showing ST-segment elevation in V3, V4, and V5 leads , and increased troponin T (0.542 ng/ml) and CK-MB levels (25 u/l), confirming acute myocardial infarction (AMI). The mechanism of AMI secondary to IE is either compression by aortic periannular lesions or embolism . Because his aorta was not involved, embolism was a concern. Repeat echocardiography showed left ventricular regional and segmental abnormal movement during contraction, supporting AMI. We elected not to initiate antiplatelet therapy, because of his cerebral infarction and splenic abscess, but valve surgery was planned. Unfortunately, 2 days later, he experienced acute-onset sharp abdominal pain with cold limbs, tenderness, muscle tension, guarding, hypotension, and tachycardia, suggesting peritonitis and shock. Bedside ultrasound revealed a 23-mm anechoic area in the abdominal cavity, and intraperitoneal hemorrhage was confirmed by abdominocentesis. Spontaneous splenic rupture was confirmed on emergency laparotomy. A necrotic area was seen in a section of the extracted spleen , and necrotic tissue with massive neutrophil and macrophage infiltration was observed microscopically, suggesting abscess formation secondary to septic embolism . Mitral valvuloplasty was performed after the patient’s presentation, with vegetation resection, posterior valve repair, and flexible annuloplasty ring placement . Pathological analysis revealed mucoid degeneration of the mitral valve, inflammatory cell infiltration, and mural thrombus formation . We diagnosed mucoid degeneration and mitral valve prolapse (Barlow’s disease) as the underlying etiology of the endocardial lesion. Transthoracic echocardiography 1.5, 3, and 6 months after the onset of his illness showed no regurgitation, and there was no respiratory distress, fever, or lethargy during follow-up. Fig. 1 Diagnostic findings. a . Cranial T2-magnetic resonance image showing high signal intensity in the left hemisphere ( red arrow ); b . Echocardiograph clearly shows a sizeable vegetation on the mitral valve (red arrow); c . Abdominal ultrasound showing multiple echo-free areas ( red arrow ) in the spleen, indicating liquefactive necrosis and abscess formation; d . Color Doppler showing severe mitral regurgitation Fig. 2 Electrocardiogram tracing. a . ST segment elevation in leads V3–V5 ( arrow ) combined with abnormal serum troponin T levels indicated acute coronary syndrome; b . ST segment descends gradually to baseline Fig. 3 Pathological and gross valve findings. a . Necrotic area ( yellow arrow ) and solid abscess ( red arrow ) were seen in a section of removed spleen; b. Necrotic tissue and high neutrophil and macrophage infiltration ( white arrow ) were seen microscopically (magnification, ×200); c . Valvular vegetation resected during heart surgery; d. Mucoid degeneration of the mitral valve, fibrinous exudation with inflammatory cell infiltration, and mural thrombus formation are seen microscopically (magnification × 100)
| 4.070313
| 0.974609
|
sec[1]/p[0]
|
en
| 0.999996
|
27514369
|
https://doi.org/10.1186/s12879-016-1726-5
|
[
"mitral",
"valve",
"arrow",
"abscess",
"formation",
"vegetation",
"ventricular",
"abdominal",
"spleen",
"necrotic"
] |
[
{
"code": "BB60.Z",
"title": "Mitral valve stenosis, unspecified"
},
{
"code": "LA89.2",
"title": "Mitral atresia"
},
{
"code": "BB6Z",
"title": "Mitral valve disease, unspecified"
},
{
"code": "LA87.11",
"title": "Congenital mitral valvar stenosis"
},
{
"code": "LA87.10",
"title": "Congenital mitral regurgitation"
},
{
"code": "GB61.Z",
"title": "Chronic kidney disease, stage unspecified"
},
{
"code": "BC00",
"title": "Multiple valve disease"
},
{
"code": "BB9Z",
"title": "Pulmonary valve disease, unspecified"
},
{
"code": "LA8Z",
"title": "Structural developmental anomaly of heart or great vessels, unspecified"
},
{
"code": "1B75.3",
"title": "Pyogenic abscess of the skin"
}
] |
=== ICD-11 CODES FOUND ===
[BB60.Z] Mitral valve stenosis, unspecified
Also known as: Mitral valve stenosis, unspecified | Mitral valve stenosis | MS - [mitral stenosis] | mitral stenosis | mitral valvular stricture
[LA89.2] Mitral atresia
Definition: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve.
Also known as: Mitral atresia | Mitral atresia with absent atrioventricular connection | absent left atrioventricular connection or junction | absent left atrioventricular connection in laevocardia | mitral atresia with absent valvar annulus
[BB6Z] Mitral valve disease, unspecified
Also known as: Mitral valve disease, unspecified | noninfective endocarditis of mitral valve | rheumatic heart disease of mitral valve, unspecified | mitral valvulopathy | mitral valve cardiopathy
[LA87.11] Congenital mitral valvar stenosis
Definition: A congenital cardiovascular malformation of the mitral valve in which there is narrowing or stricture of the valvar orifice (obstruction to flow).
Also known as: Congenital mitral valvar stenosis | Duroziez disease | congenital mitral stenosis | congenital stenosis of mitral valve | congenital mitral valve stricture
[LA87.10] Congenital mitral regurgitation
Definition: A congenital cardiovascular finding in which there is backward flow through the mitral valve.
Also known as: Congenital mitral regurgitation | congenital insufficiency of mitral valve | congenital mitral insufficiency | congenital mitral valve incompetence | congenital mitral valve insufficiency
[GB61.Z] Chronic kidney disease, stage unspecified
Also known as: Chronic kidney disease, stage unspecified | Chronic kidney disease | chronic renal failure | chronic kidney failure | chronic renal disease
[BC00] Multiple valve disease
Also known as: Multiple valve disease | Multiple valve disease of unspecified origin | multiple valvular cardiac dysfunction | multivalvular cardiac dysfunction | Disorders of both mitral and aortic valves
[BB9Z] Pulmonary valve disease, unspecified
Also known as: Pulmonary valve disease, unspecified | rheumatic heart disease of pulmonary valve, unspecified | chronic rheumatic pulmonary valve endocarditis | chronic rheumatic pulmonary valvular endocarditis | rheumatic disease of pulmonary valve
[LA8Z] Structural developmental anomaly of heart or great vessels, unspecified
Also known as: Structural developmental anomaly of heart or great vessels, unspecified | Heart malformations | Cardiac malformations | congenital anomaly of heart | congenital heart disease
[1B75.3] Pyogenic abscess of the skin
Definition: A pus-producing abscess of the skin most commonly due to bacterial infection by Staphylococcus aureus. It is prone to develop where the normal anatomy is disturbed as in pilonidal disease, an epidermoid cyst or around foreign bodies such as surgical sutures.
Also known as: Pyogenic abscess of the skin | abscess NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[BB60.Z] Mitral valve stenosis, unspecified
--PARENT--> [BB60] Mitral valve stenosis
--RELATED_TO--> [?] Postprocedural mitral valve stenosis
--- Walk 2 ---
[BB60.Z] Mitral valve stenosis, unspecified
--PARENT--> [BB60] Mitral valve stenosis
--EXCLUDES--> [?] Mitral valve stenosis with insufficiency
Def: This is a valvular heart disease characterised by the narrowing of the orifice of the mitral valve of the heart, with regurgitation....
--- Walk 3 ---
[LA89.2] Mitral atresia
Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....
--PARENT--> [LA89] Functionally univentricular heart
Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...
--PARENT--> [?] Structural developmental anomaly of heart or great vessels
Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....
--- Walk 4 ---
[LA89.2] Mitral atresia
Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....
--PARENT--> [LA89] Functionally univentricular heart
Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...
--CHILD--> [LA89.2] Mitral atresia
Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....
--- Walk 5 ---
[BB6Z] Mitral valve disease, unspecified
--PARENT--> [?] Mitral valve disease
Def: This is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle through the mitral valve i...
--CHILD--> [BB60] Mitral valve stenosis
--- Walk 6 ---
[BB6Z] Mitral valve disease, unspecified
--PARENT--> [?] Mitral valve disease
Def: This is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle through the mitral valve i...
--EXCLUDES--> [?] Congenital anomaly of mitral valve
Def: A congenital cardiac malformation in which there is an abnormality of the mitral valve....
|
[
"[BB60.Z] Mitral valve stenosis, unspecified\n --PARENT--> [BB60] Mitral valve stenosis\n --RELATED_TO--> [?] Postprocedural mitral valve stenosis",
"[BB60.Z] Mitral valve stenosis, unspecified\n --PARENT--> [BB60] Mitral valve stenosis\n --EXCLUDES--> [?] Mitral valve stenosis with insufficiency\n Def: This is a valvular heart disease characterised by the narrowing of the orifice of the mitral valve of the heart, with regurgitation....",
"[LA89.2] Mitral atresia\n Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....\n --PARENT--> [LA89] Functionally univentricular heart\n Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...\n --PARENT--> [?] Structural developmental anomaly of heart or great vessels\n Def: A congenital malformation of the heart and/or great vessels or an acquired abnormality unique to the congenitally malformed heart....",
"[LA89.2] Mitral atresia\n Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....\n --PARENT--> [LA89] Functionally univentricular heart\n Def: The term “functionally univentricular heart” describes a spectrum of congenital cardiovascular malformations in which the ventricular mass may not readily lend itself to partitioning that commits one ...\n --CHILD--> [LA89.2] Mitral atresia\n Def: A congenital cardiovascular malformation with absence of the mitral valvar annulus (connection/junction) or an imperforate mitral valve....",
"[BB6Z] Mitral valve disease, unspecified\n --PARENT--> [?] Mitral valve disease\n Def: This is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle through the mitral valve i...\n --CHILD--> [BB60] Mitral valve stenosis",
"[BB6Z] Mitral valve disease, unspecified\n --PARENT--> [?] Mitral valve disease\n Def: This is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle through the mitral valve i...\n --EXCLUDES--> [?] Congenital anomaly of mitral valve\n Def: A congenital cardiac malformation in which there is an abnormality of the mitral valve...."
] |
BB60.Z
|
Mitral valve stenosis, unspecified
|
[
{
"from_icd11": "BB60.Z",
"icd10_code": "I050",
"icd10_title": "Rheumatic mitral stenosis"
},
{
"from_icd11": "BB60.Z",
"icd10_code": "I342",
"icd10_title": "Nonrheumatic mitral (valve) stenosis"
},
{
"from_icd11": "LA89.2",
"icd10_code": "Q232",
"icd10_title": "Congenital mitral stenosis"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I059",
"icd10_title": "Rheumatic mitral valve disease, unspecified"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I058",
"icd10_title": "Other rheumatic mitral valve diseases"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I348",
"icd10_title": "Other nonrheumatic mitral valve disorders"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I349",
"icd10_title": "Nonrheumatic mitral valve disorder, unspecified"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I05-I09",
"icd10_title": ""
},
{
"from_icd11": "BB6Z",
"icd10_code": "I05",
"icd10_title": "Rheumatic mitral valve diseases"
},
{
"from_icd11": "BB6Z",
"icd10_code": "I390",
"icd10_title": ""
},
{
"from_icd11": "BB6Z",
"icd10_code": "I34",
"icd10_title": "Nonrheumatic mitral valve disorders"
},
{
"from_icd11": "LA87.10",
"icd10_code": "Q233",
"icd10_title": "Congenital mitral insufficiency"
},
{
"from_icd11": "GB61.Z",
"icd10_code": "N183",
"icd10_title": "Chronic kidney disease, stage 3 (moderate)"
},
{
"from_icd11": "GB61.Z",
"icd10_code": "N189",
"icd10_title": "Chronic kidney disease, unspecified"
},
{
"from_icd11": "GB61.Z",
"icd10_code": "N250",
"icd10_title": "Renal osteodystrophy"
}
] |
I050
|
Rheumatic mitral stenosis
|
A 17-year-old female patient was admitted to the neurology department of our hospital on March 25, 2024, mainly due to involuntary limb shaking for 7.5 hours. A 7.5 hours before admission, the patient had involuntary limb shaking without obvious inducement, mainly in the right upper limb. Three hours before admission, the patient had no language, eyes were straight, and symptoms continued to be unsolved. The patient was admitted to the emergency department of our hospital, and no abnormalities were found in skull computed tomography (CT) and skull diffusion-weighted imaging + magnetic resonance angiography. Filed under “Involuntary Movement pending Investigation.” The patient was previously healthy and had a history of upper respiratory tract infection. When admitted to hospital, the body temperature was 37.7 °C, the nervous system physical examination: clear consciousness, silent, lack of cooperation in physical examination, increased muscle tension of limbs, involuntary shaking of both upper limbs, bilateral pathological signs were negative. The initial diagnosis was involuntary limb movement. After admission, ceftriaxone was given anti-infection treatment and ganciclovir antiviral treatment. Complete examination and examination on admission: electrocardiogram: 1. sinus tachycardia 2. generally normal electrocardiogram: urine analysis: ketone body: 1+, abnormal; blood gas analysis, biochemical whole item + SAA + CRP, blood homocysteine, preoperative 8 items, 6 items of thyroid function, serum folic acid, vitamin B12 were not significantly abnormal. Head magnetic resonance imaging (MRI) showed no significant abnormalities . No significant abnormality was found on cervical vascular ultrasound and subclavian artery ultrasound. On the second day of admission, the head enhanced MRI, electroencephalogram, and lumbar puncture were completed, and the cerebrospinal fluid was examined for autoimmune antibodies and infection-related tests. There were no significant abnormalities in SPGR + CUBE enhanced skull magnetic resonance. There were no obvious abnormalities in the electroencephalogram . Cerebrospinal fluid biochemistry: cerebrospinal fluid sugar: 79.82 mg/dL↑; there were no obvious abnormalities in the cytology of cerebral spinal fluid (CSF) abscission, CSF antacid ink staining, and CSF analysis. No pathogenic microorganisms were detected by high-throughput sequencing of cerebrospinal fluid. Fecal analysis and occult blood test showed no significant abnormalities. Reexamination urine analysis: leukocyte 2+. On the fourth day of admission, the results of cerebrospinal fluid testing reported 15 serum autoimmune-associated encephalitis antibodies: anti-AMPAR2 antibody 1:10, weakly positive , cerebrospinal fluid negative. A revised diagnosis was given: autoimmune encephalitis. Methylprednisolone 1 g/day and propyl bulb 20 g/day were given. On the 6th day of admission, the jitter of the patient’s right upper limb was reduced, and the 3 rheumatic factors were improved: antinuclear antibody: 1:100 abnormality: immunoglobulin G: 6.94 g/L↓; blood analysis: white blood cell count 15.67 × 10 9 /L↑, no significant abnormalities were found in all emergency items, no. 1 vasculitis screening, and all female tumors. The patient complained of cough, sputum and elevated white blood cells. Considering the presence of upper respiratory tract infection, ceftriaxone was continued to fight infection. On the 7th day of admission, methylprednisolone was adjusted to 0.5 g/day, and immunoglobulin 20 g/day impact therapy was continued. On the 8th day of admission, a complete chest CT revealed microscopic nodules in the posterior upper lobe and posterior basal lobe of the right lung. Anteroposterior X-ray of pelvis showed no abnormality in pelvic bone structure. Breast ultrasound: there was no obvious space-occupying change in the glandular layers of both mammary glands, and no obvious enlargement of lymph nodes in the armpits of both sides. Gynecologic ultrasound: uterus normal size, polycystic changes in both ovaries. On the 9th day of admission, after 5 days of treatment with methylprednisolone combined with immunoglobulin, the patient’s right upper limb involuntary jittering was reduced, muscle tone was reduced, questions and answers could be answered fluently, and immunoglobulin therapy was discontinued. On the 10th day of admission, methylprednisolone was adjusted to 240 mg/day. There were no abnormalities in the 6 items of perfect hormone. On the 13th day of admission, methylprednisolone was adjusted to 120 mg/day. On the 15th day of admission, the involuntary shaking of the limbs was significantly improved, the muscle strength of the limbs was grade 5, the muscle tension of the limbs was normal, and the speech was fluent. The patient agreed to be discharged from the hospital. After discharge, he was given oral prednisone acetate tablet 60 mg/day. During the recent follow-up, the patient recurred 2 months after discharge and was given immunotherapy again in another hospital.The patient’s diagnosis and treatment timeline is shown in Figure 4 .
| 3.935547
| 0.981445
|
sec[1]/p[0]
|
en
| 0.999996
|
40193671
|
https://doi.org/10.1097/MD.0000000000042036
|
[
"abnormalities",
"involuntary",
"fluid",
"limb",
"blood",
"cerebrospinal",
"obvious",
"infection",
"limbs",
"methylprednisolone"
] |
[
{
"code": "MB23.Z",
"title": "Symptoms and signs involving appearance and behaviour, unspecified"
},
{
"code": "GA20.3",
"title": "Abnormal regularity of uterine bleeding"
},
{
"code": "5D2Z",
"title": "Metabolic disorders, unspecified"
},
{
"code": "LD9Z",
"title": "Developmental anomalies, unspecified"
},
{
"code": "MC1Y",
"title": "Other specified symptoms or signs involving the visual system"
},
{
"code": "MF50.2Z",
"title": "Urinary incontinence, unspecified"
},
{
"code": "ME07.Z",
"title": "Faecal incontinence, unspecified"
},
{
"code": "MB47.5",
"title": "Fasciculation"
},
{
"code": "MB46.Z",
"title": "Abnormal involuntary movements, unspecified"
},
{
"code": "MB46.Y",
"title": "Other specified abnormal involuntary movements"
}
] |
=== ICD-11 CODES FOUND ===
[MB23.Z] Symptoms and signs involving appearance and behaviour, unspecified
Also known as: Symptoms and signs involving appearance and behaviour, unspecified | Symptoms or signs involving appearance or behaviour | self neglect NOS | abnormal behaviour NOS
[GA20.3] Abnormal regularity of uterine bleeding
Definition: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days.
Also known as: Abnormal regularity of uterine bleeding | Irregular menstrual bleeding | irregular cycle menstruation | irregular menses | irregular menstrual cycle
[5D2Z] Metabolic disorders, unspecified
Also known as: Metabolic disorders, unspecified | metabolic abnormality | metabolic debility | metabolic defect | metabolic disruption
[LD9Z] Developmental anomalies, unspecified
Also known as: Developmental anomalies, unspecified | congenital malformations, deformations and chromosomal abnormalities | congenital malformation NOS | developmental abnormality NOS | fetal abnormality NOS
[MC1Y] Other specified symptoms or signs involving the visual system
Also known as: Other specified symptoms or signs involving the visual system | Erythema of eyelid | Visual disturbances | disturbances of vision | difficulty seeing
[MF50.2Z] Urinary incontinence, unspecified
Also known as: Urinary incontinence, unspecified | Urinary incontinence | urinary incontinence, NOS | bladder incontinence NOS | absence of bladder continence
[ME07.Z] Faecal incontinence, unspecified
Also known as: Faecal incontinence, unspecified | Faecal incontinence | bowel incontinence | involuntary stool | faecal incontinence NOS
[MB47.5] Fasciculation
Also known as: Fasciculation | flickering muscles | fluttering muscles | muscle fasciculation | muscular fasciculation
[MB46.Z] Abnormal involuntary movements, unspecified
Also known as: Abnormal involuntary movements, unspecified | Abnormal involuntary movements | shaking | shaking all over | the shakes
[MB46.Y] Other specified abnormal involuntary movements
Also known as: Other specified abnormal involuntary movements | Reflex convulsions | Dystonic movements
=== GRAPH WALKS ===
--- Walk 1 ---
[MB23.Z] Symptoms and signs involving appearance and behaviour, unspecified
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.0] Aggressive behaviour
Def: Actions intended to threaten or hurt another person or to damage property that may be physical, verbal, or symbolic (e.g., acting against the other person's interests). Aggressive behaviour may be app...
--- Walk 2 ---
[MB23.Z] Symptoms and signs involving appearance and behaviour, unspecified
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--- Walk 3 ---
[GA20.3] Abnormal regularity of uterine bleeding
Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....
--PARENT--> [GA20] Menstrual cycle bleeding disorders
--CHILD--> [GA20.0] Amenorrhoea
Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...
--- Walk 4 ---
[GA20.3] Abnormal regularity of uterine bleeding
Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....
--PARENT--> [GA20] Menstrual cycle bleeding disorders
--CHILD--> [GA20.2] Ovulation bleeding
Def: A condition of the genital system affecting females, caused by natural and routine fluctuations in endocrine hormones. This condition is characterised by recurrent and cyclic bleeding of the uterine l...
--- Walk 5 ---
[5D2Z] Metabolic disorders, unspecified
--PARENT--> [?] Metabolic disorders
--RELATED_TO--> [?] Cystic fibrosis
Def: Cystic fibrosis (CF) is a genetic disorder characterised by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity. The disease is chronic and generally progr...
--- Walk 6 ---
[5D2Z] Metabolic disorders, unspecified
--PARENT--> [?] Metabolic disorders
--CHILD--> [?] Disorders of metabolite absorption or transport
|
[
"[MB23.Z] Symptoms and signs involving appearance and behaviour, unspecified\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.0] Aggressive behaviour\n Def: Actions intended to threaten or hurt another person or to damage property that may be physical, verbal, or symbolic (e.g., acting against the other person's interests). Aggressive behaviour may be app...",
"[MB23.Z] Symptoms and signs involving appearance and behaviour, unspecified\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....",
"[GA20.3] Abnormal regularity of uterine bleeding\n Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....\n --PARENT--> [GA20] Menstrual cycle bleeding disorders\n --CHILD--> [GA20.0] Amenorrhoea\n Def: A condition of the genital system, caused by hormonal or endocrine disturbances, absence of the uterus, pregnancy, lactation, abnormalities of the genital outflow tract, or failure of the ovaries to r...",
"[GA20.3] Abnormal regularity of uterine bleeding\n Def: A condition of the genital system affecting females, caused by hormonal disturbances. This condition is characterised by abnormal menstruation, with a between cycle variation of 2-20 days....\n --PARENT--> [GA20] Menstrual cycle bleeding disorders\n --CHILD--> [GA20.2] Ovulation bleeding\n Def: A condition of the genital system affecting females, caused by natural and routine fluctuations in endocrine hormones. This condition is characterised by recurrent and cyclic bleeding of the uterine l...",
"[5D2Z] Metabolic disorders, unspecified\n --PARENT--> [?] Metabolic disorders\n --RELATED_TO--> [?] Cystic fibrosis\n Def: Cystic fibrosis (CF) is a genetic disorder characterised by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity. The disease is chronic and generally progr...",
"[5D2Z] Metabolic disorders, unspecified\n --PARENT--> [?] Metabolic disorders\n --CHILD--> [?] Disorders of metabolite absorption or transport"
] |
MB23.Z
|
Symptoms and signs involving appearance and behaviour, unspecified
|
[
{
"from_icd11": "MB23.Z",
"icd10_code": "R4689",
"icd10_title": "Other symptoms and signs involving appearance and behavior"
},
{
"from_icd11": "MB23.Z",
"icd10_code": "R4681",
"icd10_title": "Obsessive-compulsive behavior"
},
{
"from_icd11": "MB23.Z",
"icd10_code": "R46",
"icd10_title": "Symptoms and signs involving appearance and behavior"
},
{
"from_icd11": "MB23.Z",
"icd10_code": "R466",
"icd10_title": "Undue concern and preoccupation with stressful events"
},
{
"from_icd11": "MB23.Z",
"icd10_code": "R468",
"icd10_title": "Other symptoms and signs involving appearance and behavior"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N926",
"icd10_title": "Irregular menstruation, unspecified"
},
{
"from_icd11": "GA20.3",
"icd10_code": "N925",
"icd10_title": "Other specified irregular menstruation"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8840",
"icd10_title": "Mitochondrial metabolism disorder, unspecified"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8849",
"icd10_title": "Other mitochondrial metabolism disorders"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8841",
"icd10_title": "MELAS syndrome"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8842",
"icd10_title": "MERRF syndrome"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8809",
"icd10_title": "Other disorders of plasma-protein metabolism, not elsewhere classified"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8881",
"icd10_title": "Metabolic syndrome"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8889",
"icd10_title": "Other specified metabolic disorders"
},
{
"from_icd11": "5D2Z",
"icd10_code": "E8801",
"icd10_title": "Alpha-1-antitrypsin deficiency"
}
] |
R4689
|
Other symptoms and signs involving appearance and behavior
|
An older patient presenting to the emergency department for altered mental status and first-time seizure must be evaluated for a broad differential. In this case, the patient was found with an empty bottle of dicyclomine so there was significant concern for dicyclomine overdose. There were also multiple signs and symptoms present at initial evaluation consistent with anticholinergic overdose such as hallucinations, mydriasis, tachycardia, delirium, and urinary retention. Additionally, the resolution of the arrhythmia with clearance of the dicyclomine was also consistent with anticholinergic toxicity. Other ingestions were considered as well. Blood acetaminophen, salicylate, and ethanol levels were undetectable. Urine drug screen was positive for opiates, benzodiazepines, and cannabis. However, the patient had received midazolam from emergency medical services (EMS) for seizure before this urine sample was obtained. The family reported that the patient no longer had access to her previously prescribed alprazolam. The positive benzodiazepine result was most likely from the appropriate dose of midazolam administered by EMS. Benzodiazepine overdose was therefore unlikely. The patient's symptoms developed a week after the discontinuation of alprazolam. It was therefore believed that the patient was outside of the window for acute benzodiazepine withdrawal. The patient was also prescribed hydrocodone-acetaminophen for chronic pain, which explains the positive screen for opiates. The patient's presentation with dilated pupils and tachypnea was not consistent with the expected miosis and bradypnea expected with opioid overdose. The patient did not have an elevated anion gap metabolic acidosis to suggest ingesting toxins such as methanol, ethylene glycol, isopropanol, valproic acid, topiramate, or lithium. Intracranial pathology was also considered. CT of the brain without contrast revealed crowding of convexity sulci, which may be physiologic or related to cerebral edema. Repeat head CT the next day showed no change in the degree of crowding of the sulci over the cerebral hemispheres. The patient also had no known cause for cerebral edema. Therefore, it was presumed these CT findings were more likely physiologic and less likely due to true cerebral edema. Endocrine and electrolyte abnormalities were also considered. However, blood glucose and thyroid-stimulating hormone levels were within normal limits. The patient was noted to have hyponatremia (serum sodium 120 mmol/L) and mild hypomagnesemia (serum magnesium 1.5 mmol/L) at the initial presentation. Hyponatremia is a common cause of altered mental status and seizure. There are also case reports documenting patients with sinus pause or other cardiac electrical conduction abnormalities in the setting of hyponatremia and hyperkalemia . In that case, the patient had a serum sodium level of 102 mmol/L correlating with sinus pauses and junctional escape rhythm during 24-hour Holter monitoring . Hyperkalemia (serum potassium of 6 mmol/L) introduced a potential confounding factor in that case. However, it was felt that electrolyte abnormalities did not contribute to our patient's intermittent sinus pause as the arrhythmia continued after the patient's electrolytes normalized. For example, the patient continued to require intermittent transvenous pacing on hospital day 4. At that time, the serum sodium level was within normal limits at 140 mmol/L and had been within normal limits for over 24 hours. Additionally, most cases of hyponatremia-induced arrhythmia and seizure occur at sodium levels less than 110-115 mmol/L, much lower than our patient's initial sodium. An infection could also explain the patient's mild tachycardia, low-grade fever, and leukocytosis (white blood cell count of 19.3×10 9 /L). However, the patient's procalcitonin level was within normal limits, suggesting a low likelihood of bacterial infection. The patient also had no infectious symptoms to suggest viral or bacterial infection prior to the sudden onset of altered mental status. Finally, cardiac pathology was also considered. The patient's EKG showed no acute ischemic changes, and serum troponin was not elevated. The echocardiogram showed normal left ventricular systolic function with an estimated ejection fraction of 65-70%. There were normal diastolic function, no regional wall motion abnormalities, and no significant valvular abnormalities. Sick sinus syndrome could have explained the patient's arrhythmias but was deemed unlikely as the patient had no preceding history suggestive of sick sinus syndrome such as syncope, dizziness, palpitations, or pre-syncope. Additionally, the episodes of sinus pause resolved by hospital day 5 and have not recurred since. The patient's medication history was unremarkable for agents affecting sinoatrial (SA) node function or heart rate modulation. All medical teams involved in the patient's care concurred that the observed episodes of sinus pause most likely stemmed from anticholinergic toxicity, supported by the self-resolving nature of symptoms and corroborating history.
| 4.109375
| 0.966797
|
sec[2]/p[0]
|
en
| 0.999996
|
39867509
|
https://doi.org/10.7759/cureus.77959
|
[
"that",
"sinus",
"serum",
"mmol",
"abnormalities",
"sodium",
"seizure",
"overdose",
"considered",
"however"
] |
[
{
"code": "8A80.Z",
"title": "Migraine, unspecified"
},
{
"code": "QA76",
"title": "Medication or substance that is known to be an allergen without injury or harm"
},
{
"code": "PL13.6",
"title": "Medication or substance that is known to be an allergen, as mode of injury or harm"
},
{
"code": "9C40.A0",
"title": "Papilloedema"
},
{
"code": "PA6Z",
"title": "Unintentional fall from unspecified height"
},
{
"code": "CA0A.Z",
"title": "Chronic rhinosinusitis, unspecified"
},
{
"code": "CA0Y&XA3523",
"title": "Nasal sinus obstruction"
},
{
"code": "CA0J.Y",
"title": "Other specified nasal polyp"
},
{
"code": "LB03.Y",
"title": "Other specified structural developmental anomalies of umbilical cord"
},
{
"code": "DA09.61",
"title": "Periapical abscess with sinus"
}
] |
=== ICD-11 CODES FOUND ===
[8A80.Z] Migraine, unspecified
Also known as: Migraine, unspecified | Migraine
[QA76] Medication or substance that is known to be an allergen without injury or harm
Definition: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm.
Also known as: Medication or substance that is known to be an allergen without injury or harm
Excludes: Medication or substance that is known to be an allergen, as mode of injury or harm
[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm
Also known as: Medication or substance that is known to be an allergen, as mode of injury or harm | medication error relating to known allergy to drug or substance | adverse drug event relating to known allergy to drug or substance
[9C40.A0] Papilloedema
Definition: Optic disc swelling that results from increased intracranial pressure
Also known as: Papilloedema | Optic disc swelling that results from increased intracranial pressure
Includes: Optic disc swelling that results from increased intracranial pressure
[PA6Z] Unintentional fall from unspecified height
Also known as: Unintentional fall from unspecified height | fall NOS | accidental fall | fall causing injury that resulted in death | fell NOS
[CA0A.Z] Chronic rhinosinusitis, unspecified
Also known as: Chronic rhinosinusitis, unspecified | Chronic rhinosinusitis | Chronic sinusitis | chronic sinusitis NOS | unspecified sinusitis
[CA0J.Y] Other specified nasal polyp
Also known as: Other specified nasal polyp | Polyp of nasal cavity | Polyp of the nasopharynx | nasopharyngeal polyp | Polyp of adenoid tissue
[LB03.Y] Other specified structural developmental anomalies of umbilical cord
Also known as: Other specified structural developmental anomalies of umbilical cord | Umbilical cord calcifications | Omphalomesenteric duct remnants or cysts | Vitelline duct remnants and cysts | Persistent omphalomesenteric duct
[DA09.61] Periapical abscess with sinus
Also known as: Periapical abscess with sinus | Dental abscess with sinus | Dentoalveolar abscess with sinus | Dental sinus | periapical abscess fistula
Includes: Dental abscess with sinus | Dentoalveolar abscess with sinus | Dental sinus
=== GRAPH WALKS ===
--- Walk 1 ---
[8A80.Z] Migraine, unspecified
--PARENT--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
--EXCLUDES--> [?] Headache, not elsewhere classified
Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....
--- Walk 2 ---
[8A80.Z] Migraine, unspecified
--PARENT--> [8A80] Migraine
Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...
--CHILD--> [8A80.2] Chronic migraine
Def: Headache occurring on 15 or more days per month for more than three months, which, on at least eight days per month, has the features of migraine headache and is not associated with medication overuse...
--- Walk 3 ---
[QA76] Medication or substance that is known to be an allergen without injury or harm
Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....
--EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--- Walk 4 ---
[QA76] Medication or substance that is known to be an allergen without injury or harm
Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....
--EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--- Walk 5 ---
[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [PL13] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--CHILD--> [PL13.0] Overdose of substance, as mode of injury or harm
Def: Incorrect dose - too high...
--- Walk 6 ---
[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm
--PARENT--> [PL13] Mode of injury or harm associated with exposure to a drug, medicament or biological substance
--CHILD--> [PL13.1] Underdosing, as mode of injury or harm
|
[
"[8A80.Z] Migraine, unspecified\n --PARENT--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...\n --EXCLUDES--> [?] Headache, not elsewhere classified\n Def: Headache with characteristic features suggesting that it is a unique diagnostic entity, a finding or complaint, but not fulfilling criteria for any of the headache disorders described above....",
"[8A80.Z] Migraine, unspecified\n --PARENT--> [8A80] Migraine\n Def: A primary headache disorder, in most cases episodic. Disabling attacks lasting 4-72 hours are characterised by moderate or severe headache, usually accompanied by nausea, vomiting and/or photophobia a...\n --CHILD--> [8A80.2] Chronic migraine\n Def: Headache occurring on 15 or more days per month for more than three months, which, on at least eight days per month, has the features of migraine headache and is not associated with medication overuse...",
"[QA76] Medication or substance that is known to be an allergen without injury or harm\n Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....\n --EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance",
"[QA76] Medication or substance that is known to be an allergen without injury or harm\n Def: Medication that has previously been identified as an allergen to the patient is administered, but does not result in injury or harm....\n --EXCLUDES--> [?] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [?] Mode of injury or harm associated with exposure to a drug, medicament or biological substance",
"[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [PL13] Mode of injury or harm associated with exposure to a drug, medicament or biological substance\n --CHILD--> [PL13.0] Overdose of substance, as mode of injury or harm\n Def: Incorrect dose - too high...",
"[PL13.6] Medication or substance that is known to be an allergen, as mode of injury or harm\n --PARENT--> [PL13] Mode of injury or harm associated with exposure to a drug, medicament or biological substance\n --CHILD--> [PL13.1] Underdosing, as mode of injury or harm"
] |
8A80.Z
|
Migraine, unspecified
|
[
{
"from_icd11": "8A80.Z",
"icd10_code": "G43B0",
"icd10_title": "Ophthalmoplegic migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43409",
"icd10_title": "Hemiplegic migraine, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43A0",
"icd10_title": "Cyclical vomiting, in migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43D0",
"icd10_title": "Abdominal migraine, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43709",
"icd10_title": "Chronic migraine without aura, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43A1",
"icd10_title": "Cyclical vomiting, in migraine, intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43509",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43719",
"icd10_title": "Chronic migraine without aura, intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43501",
"icd10_title": "Persistent migraine aura without cerebral infarction, not intractable, with status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43C0",
"icd10_title": "Periodic headache syndromes in child or adult, not intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43401",
"icd10_title": "Hemiplegic migraine, not intractable, with status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43419",
"icd10_title": "Hemiplegic migraine, intractable, without status migrainosus"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43B1",
"icd10_title": "Ophthalmoplegic migraine, intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43C1",
"icd10_title": "Periodic headache syndromes in child or adult, intractable"
},
{
"from_icd11": "8A80.Z",
"icd10_code": "G43D1",
"icd10_title": "Abdominal migraine, intractable"
}
] |
G43B0
|
Ophthalmoplegic migraine, not intractable
|
A 24-year-old female patient was admitted to the Department of Neurology at Liaocheng People's Hospital due to persistent amenorrhea for 2 years and weakness of both lower limbs for the past 10 months. She had no remarkable medical history, except for raising the head and walking later than other children of the same age. There was no problem with the pregnancy or delivery and also no history of drug abuse or hallucinations. No consanguineous marriage in her family was reported. She had irregular menstruation with prolonged menstrual cycles. The first symptom of amenorrhea or absence of menstruation was recorded when the patient was 22 years old. The patient felt like stepping on cotton when walking, and it was a little bit difficult for her to stand up after sitting. At the initial phase, these clinical symptoms were slightly improved after a short period of symptomatic manifestations. However, she started to seclude herself from social activities, while her bilateral lower extremity weakness progressively deteriorated without a remitting period. She also exhibited signs of cognitive decline and abnormal mental behaviors. For example, she had a slow reaction time and always presented delayed responses to doctor’s questions. Reduced communicative participation was noted in this patient during the initial screening. Her calculating and reading abilities were also decreased progressively. She had been suffering from motor function deficits (lower limb tremor, bradykinesia and rigid muscles), requiring active physical assistance for daily activities. Upon neurological evaluation, her muscle strengths of all four limbs were graded as 4-/5. A decreased sense of vibration and numbness of lower limbs were recorded in lower extremities. Moderate station ataxia (Romberg test) and tandem walking tests were not feasible in this patient. The tendon reflexes of lower limbs were sightly active and other remarkable signs, including bilateral Babinski sign and Kernig sign, were not evident. Routine laboratory investigations indicated normal renal and hepatic functions. The endocrinological hormone profiling in the serum showed that the levels of estradiol were 33.473 pg/ml (Reference ranges, follicular phase: 26.6–161 pg/ml; luteal phase: 187–382 pg/ml; ovulation: 187–382 pg/ml; menopause: 5.37–38.4 pg/ml), luteinizing hormone was 55.7mIU/ml (Reference ranges, follicular phase: 2.58–12.1 mIU/ml; luteal phase: 0.83–15.5 mIU/ml; menopause: 13.1–86.5 mIU/ml), and follicle-stimulating hormone was 87.9 mIU/ml (Reference ranges, follicular phase: 1.98–11.6 mIU/ml; luteal phase: 1.38–9.58 mIU/ml; menopause: 21.5–131 mIU/ml). Blood tests for the levels of very-long-chain fatty acids and lysosomal enzyme activities were unremarkable. T2-weighted sagittal and fluid-attenuated inversion recovery (FLAIR) images revealed white matter hyperintensities and abnormal signals on bilateral periventricular regions, corona radiata, and corpus callosum . White matter rarefaction was visible on FLAIR. Restricted diffusion in selective white matter was noted . Magnetic resonance spectroscopy (MRS) showed an increased ratio of Cho and Cr in frontal lesions . Whole-exome sequencing results indicated that the exon4 of the AARS2 gene contained a missense mutation at c.718C > T (p.Leu240Phe) in this proband , when matched with the HG19 reference genome sequence and the transcript variant NM_020745.3. In silico analyses using multiple bioinformatics methods suggested this mutation as ‘probably damaging’. Furthermore, an alternative splicing mutation was also noted , as confirmed by in silico analysis (a pathological variant). Both transcript variants were not previously reported in the general population database and might have deleterious effects. The father of this patient carried a heterozygous AARS2 gene mutation , and the mother also had a heterozygous mutation c.718C > T in the same gene. The patient’s brother did not show either of these variants. Coenzyme complex treatment and glucocorticoid therapy had no therapeutic impact on this patient. During the recent follow-up visit, her health condition was found to be worsened further, and the patient’s movement was mostly restricted to bed. Fig. 1 Brain magnetic resonance imaging of this patient ( A - D ) Axial T1W1, T2WI, fluid-attenuated inversion recovery (FLAIR) and diffuse weighted imaging (DWI), respectively. T1-hypointense and hyperintense signal abnormalities on T2W1 and FLAIR can be noted around the corpus callosum and bilateral ventricles. Diffusion restriction in selective white matter was noted. E Magnetic resonance spectroscopy (MRS) showed an increased Cho/Cr ratio in frontal lesions Fig. 2 AARS2 gene mutations (missense mutation) in the patient and her father. The patient had a missense mutation in the AARS2 gene c.718C > T (p.Leu240Phe). The variant was transmitted paternally (red arrows) Fig. 3 AARS2 gene mutation (splicing mutation) in the patient and her mother. The patient had a splicing mutation in the AARS2 gene c.1040 + 1G > A (p.?). The variant was transmitted maternally (red arrows)
| 4.195313
| 0.963379
|
sec[1]/p[0]
|
en
| 0.999997
|
PMC9175470
|
https://doi.org/10.1186/s12883-022-02720-3
|
[
"mutation",
"phase",
"this",
"gene",
"limbs",
"reference",
"flair",
"white",
"matter",
"variant"
] |
[
{
"code": "GB90.4A",
"title": "Nephrogenic diabetes insipidus"
},
{
"code": "8A02.12",
"title": "Dystonia associated with heredodegenerative disorders"
},
{
"code": "4A01.21",
"title": "Immune dysregulation syndromes presenting primarily with autoimmunity"
},
{
"code": "8C73.Z",
"title": "Mitochondrial myopathies, unspecified"
},
{
"code": "8E02.0",
"title": "Genetic Creutzfeldt-Jakob disease"
},
{
"code": "JB02.0",
"title": "Primary uterine inertia"
},
{
"code": "2B30.10&XH51K7",
"title": "Classical Hodgkin lymphoma, nodular sclerosis, cellular phase"
},
{
"code": "7A60",
"title": "Delayed sleep-wake phase disorder"
},
{
"code": "MD93",
"title": "Dysphagia"
},
{
"code": "JB02.1",
"title": "Secondary uterine inertia"
}
] |
=== ICD-11 CODES FOUND ===
[GB90.4A] Nephrogenic diabetes insipidus
Definition: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipatio
Also known as: Nephrogenic diabetes insipidus | renal diabetes insipidus | familial nephrogenic diabetes | antidiuretic-hormone-resistant diabetes insipidus | adiuretin-resistant diabetes insipidus
Excludes: Central diabetes insipidus
[8A02.12] Dystonia associated with heredodegenerative disorders
Definition: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen.
Also known as: Dystonia associated with heredodegenerative disorders | Dystonia due to autosomal dominant disorders | Rapid-onset dystonia-parkinsonism | Dystonia due to dentatorubropallidoluysian atrophy | Dystonia due to Huntington disease
[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity
Also known as: Immune dysregulation syndromes presenting primarily with autoimmunity | Syndrome with autoimmunity | Immunodeficiency syndromes presenting primarily with autoimmunity | FADD-related immunodeficiency | X-linked immune dysregulation – polyendocrinopathy – enteropathy
[8C73.Z] Mitochondrial myopathies, unspecified
Also known as: Mitochondrial myopathies, unspecified | Mitochondrial myopathies | Myopathies in mitochondrial disorders
[8E02.0] Genetic Creutzfeldt-Jakob disease
Definition: A disease of the brain, that is associated with a prion. This disease is characterised by neurological deficits, and is fatal. Confirmation is by pathological examination of the brain.
Also known as: Genetic Creutzfeldt-Jakob disease | CJD - [Creutzfeldt-Jakob disease] | Creutzfeldt-Jakob | Creutzfeldt-Jakob disease | JCD - [Jakob-Creutzfeldt disease]
[JB02.0] Primary uterine inertia
Definition: A condition affecting pregnant females characterised by insufficiently strong or inappropriately coordinated rhythmic activity of the myometrium during labour to efface and dilate the cervix.
Also known as: Primary uterine inertia | Primary hypotonic uterine dysfunction | hypotonic uterine dysfunction | hypotonic uterine inertia | primary hypotonic uterine inertia
Includes: Primary hypotonic uterine dysfunction | Uterine inertia during latent phase of labour | Primary inadequate contractions
[7A60] Delayed sleep-wake phase disorder
Definition: Delayed sleep-wake phase disorder is a recurrent pattern of disturbance of the sleep-wake schedule characterised by persistent delay in the major sleep period compared to conventional or desired sleep times. The disorder results in difficulty falling asleep and difficulty awakening at desired or required times. When sleep is allowed to occur on the delayed schedule, it is essentially normal in quality and duration. The symptoms should have persisted for at least several months and result in sign
Also known as: Delayed sleep-wake phase disorder | circadian rhythm sleep-wake disorder, delayed type | delayed sleep phase syndrome
Includes: delayed sleep phase syndrome
[MD93] Dysphagia
Definition: Difficulty in swallowing which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the pharynx and upper oesophageal sphincter; and oesophageal dysphagia due to malfunction of the oesophagus.
Also known as: Dysphagia | Difficulty in swallowing | difficulty swallowing | difficulty in swallowing NOS | swallowing problem
Includes: Difficulty in swallowing
Excludes: Functional swallowing disorder
[JB02.1] Secondary uterine inertia
Definition: A condition affecting pregnant females that is idiopathic. This condition is characterised by vigorous contractions that decrease in vigour due to exhaustion or dehydration of the individual. This condition leads to lack of labour progress.
Also known as: Secondary uterine inertia | Secondary hypotonic uterine dysfunction | secondary uterine inertia during labour | secondary hypotonic dysfunction of uterus complicating delivery | secondary hypotonic labour
Includes: Secondary hypotonic uterine dysfunction | Arrested active phase of labour
=== GRAPH WALKS ===
--- Walk 1 ---
[GB90.4A] Nephrogenic diabetes insipidus
Def: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. P...
--PARENT--> [GB90.4] Renal tubular function disorders
Def: Disorders primarily due to abnormalities of renal tubular resorption or secretion....
--RELATED_TO--> [?] Nephrogenic syndrome of inappropriate antidiuresis
--- Walk 2 ---
[GB90.4A] Nephrogenic diabetes insipidus
Def: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. P...
--PARENT--> [GB90.4] Renal tubular function disorders
Def: Disorders primarily due to abnormalities of renal tubular resorption or secretion....
--CHILD--> [GB90.41] Pseudohypoaldosteronism type 1
Def: Pseudohypoaldosteronism type 1 (PHA1) are rare forms of mineralocorticoid resistance. PHA1 presents in the newborn with renal salt wasting, failure to thrive and dehydration. Two clinical forms have b...
--- Walk 3 ---
[8A02.12] Dystonia associated with heredodegenerative disorders
Def: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen....
--PARENT--> [8A02.1] Secondary dystonia
Def: This is dystonia – a disorder of involuntary muscle contractions – of an acquired nature. Causes include substance toxicity, injury, hypoxia and tumours....
--CHILD--> [8A02.10] Drug-induced dystonia
Def: This is dystonia due to medications either as an idiosyncratic side effect or due to overdose of medications....
--- Walk 4 ---
[8A02.12] Dystonia associated with heredodegenerative disorders
Def: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen....
--PARENT--> [8A02.1] Secondary dystonia
Def: This is dystonia – a disorder of involuntary muscle contractions – of an acquired nature. Causes include substance toxicity, injury, hypoxia and tumours....
--CHILD--> [8A02.10] Drug-induced dystonia
Def: This is dystonia due to medications either as an idiosyncratic side effect or due to overdose of medications....
--- Walk 5 ---
[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity
--RELATED_TO--> [?] Syndromic multisystem autoimmune disease due to ITCH deficiency
--PARENT--> [?] Genetic disorders of the immune system affecting the skin
--- Walk 6 ---
[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity
--RELATED_TO--> [?] Aicardi-Goutières syndrome
Def: Aicardi-Goutières syndrome is an inherited, subacute encephalopathy characterised by the association of basal ganglia calcification, leukodystrophy and cerebrospinal fluid (CSF) lymphocytosis....
--CHILD--> [?] Aicardi-Goutières syndrome type 1
|
[
"[GB90.4A] Nephrogenic diabetes insipidus\n Def: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. P...\n --PARENT--> [GB90.4] Renal tubular function disorders\n Def: Disorders primarily due to abnormalities of renal tubular resorption or secretion....\n --RELATED_TO--> [?] Nephrogenic syndrome of inappropriate antidiuresis",
"[GB90.4A] Nephrogenic diabetes insipidus\n Def: Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. P...\n --PARENT--> [GB90.4] Renal tubular function disorders\n Def: Disorders primarily due to abnormalities of renal tubular resorption or secretion....\n --CHILD--> [GB90.41] Pseudohypoaldosteronism type 1\n Def: Pseudohypoaldosteronism type 1 (PHA1) are rare forms of mineralocorticoid resistance. PHA1 presents in the newborn with renal salt wasting, failure to thrive and dehydration. Two clinical forms have b...",
"[8A02.12] Dystonia associated with heredodegenerative disorders\n Def: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen....\n --PARENT--> [8A02.1] Secondary dystonia\n Def: This is dystonia – a disorder of involuntary muscle contractions – of an acquired nature. Causes include substance toxicity, injury, hypoxia and tumours....\n --CHILD--> [8A02.10] Drug-induced dystonia\n Def: This is dystonia due to medications either as an idiosyncratic side effect or due to overdose of medications....",
"[8A02.12] Dystonia associated with heredodegenerative disorders\n Def: Dystonia occurring as a part of a more complex heredodegenerative disorder. It is not a pure dystonia and other neurological findings such as ataxia, pyramidal signs and cognitive issues may be seen....\n --PARENT--> [8A02.1] Secondary dystonia\n Def: This is dystonia – a disorder of involuntary muscle contractions – of an acquired nature. Causes include substance toxicity, injury, hypoxia and tumours....\n --CHILD--> [8A02.10] Drug-induced dystonia\n Def: This is dystonia due to medications either as an idiosyncratic side effect or due to overdose of medications....",
"[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity\n --RELATED_TO--> [?] Syndromic multisystem autoimmune disease due to ITCH deficiency\n --PARENT--> [?] Genetic disorders of the immune system affecting the skin",
"[4A01.21] Immune dysregulation syndromes presenting primarily with autoimmunity\n --RELATED_TO--> [?] Aicardi-Goutières syndrome\n Def: Aicardi-Goutières syndrome is an inherited, subacute encephalopathy characterised by the association of basal ganglia calcification, leukodystrophy and cerebrospinal fluid (CSF) lymphocytosis....\n --CHILD--> [?] Aicardi-Goutières syndrome type 1"
] |
GB90.4A
|
Nephrogenic diabetes insipidus
|
[
{
"from_icd11": "GB90.4A",
"icd10_code": "N251",
"icd10_title": "Nephrogenic diabetes insipidus"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D8982",
"icd10_title": "Autoimmune lymphoproliferative syndrome [ALPS]"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D89813",
"icd10_title": "Graft-versus-host disease, unspecified"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D89810",
"icd10_title": "Acute graft-versus-host disease"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D89811",
"icd10_title": "Chronic graft-versus-host disease"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D8989",
"icd10_title": "Other specified disorders involving the immune mechanism, not elsewhere classified"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D89812",
"icd10_title": "Acute on chronic graft-versus-host disease"
},
{
"from_icd11": "4A01.21",
"icd10_code": "D898",
"icd10_title": "Other specified disorders involving the immune mechanism, not elsewhere classified"
},
{
"from_icd11": "8C73.Z",
"icd10_code": "G713",
"icd10_title": "Mitochondrial myopathy, not elsewhere classified"
},
{
"from_icd11": "8E02.0",
"icd10_code": "A8100",
"icd10_title": "Creutzfeldt-Jakob disease, unspecified"
},
{
"from_icd11": "8E02.0",
"icd10_code": "A8109",
"icd10_title": "Other Creutzfeldt-Jakob disease"
},
{
"from_icd11": "8E02.0",
"icd10_code": "A810",
"icd10_title": "Creutzfeldt-Jakob disease"
},
{
"from_icd11": "JB02.0",
"icd10_code": "O620",
"icd10_title": "Primary inadequate contractions"
},
{
"from_icd11": "MD93",
"icd10_code": "R1312",
"icd10_title": "Dysphagia, oropharyngeal phase"
},
{
"from_icd11": "MD93",
"icd10_code": "R1319",
"icd10_title": "Other dysphagia"
}
] |
N251
|
Nephrogenic diabetes insipidus
|
On August 12, 2023, a 44-year-old female patient was admitted due to the discovery of bilateral thyroid nodules during a physical examination for more than four years . The patient has no history of exposure to toxins or radioactive substances and no family history of thyroid tumors. The laboratory tests showed no abnormalities in Parathyroid Hormone (PTH), carbohydrate antigen199 (CA199), carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), carbohydrate antigen 724 (CA724), alpha-feto protein (AFP), thyroid peroxidase (TPO), Thyroid Stimulating Hormone (TSH), Triiodothyronine (T3), Thyroxine (T4), Thyroglobulin (TG), Free Triiodothyronine (FT3), Free Tetraiodothyronine (FT4) and anti-thyroglobulin antibodies (TGAB). CEA:16.13 ng/ml (reference range < 5ng/ml), Ctn: 130.00 pg/mL (reference range < 5pg/mL), both abnormally elevated . Ultrasound examination showed a solid nodule on the left side of the thyroid gland with a size of 1.2 * 0.8 * 0.9cm, low echo, clear boundary, full shape, not smooth edge and a TI-RADS classification ( 10 ) of 4A . It was recommended that malignant tumor be excluded from FNAB cytology. A solid nodule on the right side of the thyroid gland had a size of 1.3 * 0.7 * 0.9 cm, medium echo with weak echo, clear boundary, slightly full shape, smooth edge and was classified as Class 3 by TI-RADS, indicating a possible benign condition . The PET-CT whole-body bone imaging results showed a slight increase in FDG metabolism in the left thyroid nodule . An increase in FDG metabolism in the bilateral adnexal region was considered physiological uptake, and no other abnormal signs of FDG metabolism were observed. The puncture smear of the left lobe thyroid nodule under ultrasound guidance showed a small pile of glandular epithelium and no evidence of malignancy. At the same time, genetic testing is performed on the puncture cell fluid of the left lobe nodule of the thyroid gland to determine whether it is benign or malignant. The genetic testing showed a RET p.C634R somatic mutation in the left nodule and the mutation rate was 4.9%. Based on the PET-CT results, the FDG metabolism of the left thyroid nodule was increased, and laboratory Ctn and CEA were abnormally elevated. We speculate that the left thyroid nodule was likely to be sporadic medullary thyroid carcinoma (MTC). After sufficient communication and exchange with the patient, we decided to undergo surgical treatment and determine the nature of bilateral thyroid masses on August 25, 2023. During the operation, frozen tissue sections revealed ten lymph nodes in the “Left Zone III”, and no cancer metastasis has been detected yet. The left thyroid gland lobe and isthmus suggest epithelial-derived malignant tumor, considering medullary carcinoma. Intraoperative frozen sections showed nodular goiter in the right lobe of the thyroid gland. Based on the above intraoperative frozen section results, the diagnosis of bilateral thyroid masses was medullary carcinoma of the left thyroid and nodular goiter of the right thyroid. Therefore, the patient underwent total thyroidectomy with bilateral central lymph node dissection and left zone III lymph node biopsy. We also conducted molecular testing on the postoperative tissue of the right nodule while waiting for the paraffin results of the postoperative tissue. Postoperative paraffin tissue examination indicated that the left thyroid lobe was MTC , it had invaded the surrounding thyroid gland, but there was no cancer invasion in the thyroid capsule, no cancer thrombus in the vasculature, and no cancer invasion in the nerve tissue. No metastases were identified in the left central lymph nodes, suggesting regional lymph node involvement was absent. Postoperative immunohistochemical markers showed: Calcitonin (+), TTF-1 (+), CgA (+), Syn (+), CEA (+), TG (-), Ki-67 (3%+), CK19 (-), CD56 (+), P53 (wild type) . Surprisingly, residual right lobe thyroid nodules reported PTC . Postoperative paraffin tissue examination showed PTC in the residual lobe of the right thyroid gland, with no evidence of neurovascular invasion. No metastasis of cancer was found in the lymph nodes of the right central region and the left third region. The BRAF V600E mutation was also reported by molecular examination of postoperative tissue from the right nodule and the mutation rate was 14.53%. Therefore, based on the comprehensive postoperative pathology and molecular testing results, the patient’s bilateral thyroid masses were ultimately diagnosed as T1N0M0 MTC of the left thyroid and T1N0M0 PTC of the right thyroid. The patient’s postoperative condition was stable and treated with oral administration of 75 ug, qm of levothyroxine sodium tablets to inhibit TSH . On August 29, 2023, the patient’s Ctn significantly decreased to 2pg/ml, and CEA was 11.03ng/ml, still not decreased to the normal range. On September 26, 2023, the patient’s Ctn remained below 2pg/ml, and CEA significantly decreased to 2.09ng/ml , returning to normal levels—instruct patients to follow up regularly in the later stage.
| 4.089844
| 0.967285
|
sec[1]/p[0]
|
en
| 0.999997
|
40017634
|
https://doi.org/10.3389/fonc.2024.1468550
|
[
"thyroid",
"nodule",
"postoperative",
"gland",
"lobe",
"tissue",
"lymph",
"cancer",
"carbohydrate",
"metabolism"
] |
[
{
"code": "5A03.Z",
"title": "Thyroiditis, unspecified"
},
{
"code": "5A0Z",
"title": "Disorders of the thyroid gland or thyroid hormones system, unspecified"
},
{
"code": "5A03.Y",
"title": "Other specified thyroiditis"
},
{
"code": "5A00.2Z",
"title": "Acquired hypothyroidism, unspecified"
},
{
"code": "5A03.0",
"title": "Acute thyroiditis"
},
{
"code": "2E88",
"title": "Benign endometrial stromal nodule"
},
{
"code": "FA20.0",
"title": "Seropositive rheumatoid arthritis"
},
{
"code": "1F20.Z",
"title": "Aspergillosis, unspecified"
},
{
"code": "MF30",
"title": "Breast lump or mass female"
},
{
"code": "5A01.1",
"title": "Nontoxic single thyroid nodule"
}
] |
=== ICD-11 CODES FOUND ===
[5A03.Z] Thyroiditis, unspecified
Also known as: Thyroiditis, unspecified | Thyroiditis | inflammation of thyroid | thyroiditis NOS
[5A0Z] Disorders of the thyroid gland or thyroid hormones system, unspecified
Also known as: Disorders of the thyroid gland or thyroid hormones system, unspecified
[5A03.Y] Other specified thyroiditis
Also known as: Other specified thyroiditis | Riedel thyroiditis | Chronic invasive fibrous thyroiditis | Ligneous thyroiditis | Riedel struma
[5A00.2Z] Acquired hypothyroidism, unspecified
Also known as: Acquired hypothyroidism, unspecified | Acquired hypothyroidism | hypothyrea | thyroid insufficiency | hypothyroidea
[5A03.0] Acute thyroiditis
Definition: Acute thyroiditis is a rare form of thyroiditis directly caused by an infection, frequently bacterial.
Also known as: Acute thyroiditis | infectious thyroiditis | Acute thyroiditis due to bacterial infection | Acute thyroiditis due to fungal infection | Abscess of thyroid
[2E88] Benign endometrial stromal nodule
Also known as: Benign endometrial stromal nodule | benign endometrial stromal tumour | Endometrial node | Stromal nodule
[FA20.0] Seropositive rheumatoid arthritis
Also known as: Seropositive rheumatoid arthritis | high positive rheumatoid factor | low positive rheumatoid factor | high positive anticitrullinated protein antibody | low positive anticitrullinated protein antibody
[1F20.Z] Aspergillosis, unspecified
Also known as: Aspergillosis, unspecified | Aspergillosis | aspergilloma | aspergillus nodule | simple aspergilloma
[MF30] Breast lump or mass female
Also known as: Breast lump or mass female | breast irregular nodularity | breast node | lump in breast | lump or mass in breast NOS
[5A01.1] Nontoxic single thyroid nodule
Definition: Single tumour of the thyroid gland due to follicular multiplication, unaccompanied by hyperthyroidism or thyrotoxicosis
Also known as: Nontoxic single thyroid nodule | colloid goitre (in part) | follicular goitre | struma follicularis | parenchymatous goitre
=== GRAPH WALKS ===
--- Walk 1 ---
[5A03.Z] Thyroiditis, unspecified
--PARENT--> [5A03] Thyroiditis
Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...
--CHILD--> [5A03.1] Subacute thyroiditis
Def: A self-limited thyroiditis associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. It is thought to be caused by a viral infection....
--- Walk 2 ---
[5A03.Z] Thyroiditis, unspecified
--PARENT--> [5A03] Thyroiditis
Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...
--RELATED_TO--> [?] Postpartum thyroiditis
Def: Postpartum thyroiditis (PPT) is the occurrence, in the postpartum period, of transient hyperthyroidism and/or transient hypothyroidism, with most women returning to the euthyroid state by 1 year postp...
--- Walk 3 ---
[5A0Z] Disorders of the thyroid gland or thyroid hormones system, unspecified
--PARENT--> [?] Disorders of the thyroid gland or thyroid hormones system
Def: Disorders due to dysfunction of thyroid gland and regulation systems of thyroid hormone actions including dysfunction of the pituitary, hypothalamus, or thyroid hormone receptors....
--CHILD--> [5A00] Hypothyroidism
--- Walk 4 ---
[5A0Z] Disorders of the thyroid gland or thyroid hormones system, unspecified
--PARENT--> [?] Disorders of the thyroid gland or thyroid hormones system
Def: Disorders due to dysfunction of thyroid gland and regulation systems of thyroid hormone actions including dysfunction of the pituitary, hypothalamus, or thyroid hormone receptors....
--CHILD--> [5A00] Hypothyroidism
--- Walk 5 ---
[5A03.Y] Other specified thyroiditis
--PARENT--> [5A03] Thyroiditis
Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...
--EXCLUDES--> [?] Acquired hypothyroidism
Def: Acquired hypothyroidism is a condition where the thyroid gland produces too little or no thyroid hormone, and the condition arises only after birth....
--- Walk 6 ---
[5A03.Y] Other specified thyroiditis
--PARENT--> [5A03] Thyroiditis
Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...
--CHILD--> [5A03.1] Subacute thyroiditis
Def: A self-limited thyroiditis associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. It is thought to be caused by a viral infection....
|
[
"[5A03.Z] Thyroiditis, unspecified\n --PARENT--> [5A03] Thyroiditis\n Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...\n --CHILD--> [5A03.1] Subacute thyroiditis\n Def: A self-limited thyroiditis associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. It is thought to be caused by a viral infection....",
"[5A03.Z] Thyroiditis, unspecified\n --PARENT--> [5A03] Thyroiditis\n Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...\n --RELATED_TO--> [?] Postpartum thyroiditis\n Def: Postpartum thyroiditis (PPT) is the occurrence, in the postpartum period, of transient hyperthyroidism and/or transient hypothyroidism, with most women returning to the euthyroid state by 1 year postp...",
"[5A0Z] Disorders of the thyroid gland or thyroid hormones system, unspecified\n --PARENT--> [?] Disorders of the thyroid gland or thyroid hormones system\n Def: Disorders due to dysfunction of thyroid gland and regulation systems of thyroid hormone actions including dysfunction of the pituitary, hypothalamus, or thyroid hormone receptors....\n --CHILD--> [5A00] Hypothyroidism",
"[5A0Z] Disorders of the thyroid gland or thyroid hormones system, unspecified\n --PARENT--> [?] Disorders of the thyroid gland or thyroid hormones system\n Def: Disorders due to dysfunction of thyroid gland and regulation systems of thyroid hormone actions including dysfunction of the pituitary, hypothalamus, or thyroid hormone receptors....\n --CHILD--> [5A00] Hypothyroidism",
"[5A03.Y] Other specified thyroiditis\n --PARENT--> [5A03] Thyroiditis\n Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...\n --EXCLUDES--> [?] Acquired hypothyroidism\n Def: Acquired hypothyroidism is a condition where the thyroid gland produces too little or no thyroid hormone, and the condition arises only after birth....",
"[5A03.Y] Other specified thyroiditis\n --PARENT--> [5A03] Thyroiditis\n Def: Thyroiditis is the inflammation of the thyroid gland. It includes acute and chronic forms of thyroiditis. Thyroiditis is usually caused by autoimmune reaction to the thyroid, resulting in inflammation...\n --CHILD--> [5A03.1] Subacute thyroiditis\n Def: A self-limited thyroiditis associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. It is thought to be caused by a viral infection...."
] |
5A03.Z
|
Thyroiditis, unspecified
|
[
{
"from_icd11": "5A03.Z",
"icd10_code": "E069",
"icd10_title": "Thyroiditis, unspecified"
},
{
"from_icd11": "5A03.Z",
"icd10_code": "E064",
"icd10_title": "Drug-induced thyroiditis"
},
{
"from_icd11": "5A03.Z",
"icd10_code": "E065",
"icd10_title": "Other chronic thyroiditis"
},
{
"from_icd11": "5A03.Z",
"icd10_code": "E06",
"icd10_title": "Thyroiditis"
},
{
"from_icd11": "5A03.Z",
"icd10_code": "E062",
"icd10_title": "Chronic thyroiditis with transient thyrotoxicosis"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E0781",
"icd10_title": "Sick-euthyroid syndrome"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E0789",
"icd10_title": "Other specified disorders of thyroid"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E079",
"icd10_title": "Disorder of thyroid, unspecified"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E034",
"icd10_title": "Atrophy of thyroid (acquired)"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E00-E07",
"icd10_title": ""
},
{
"from_icd11": "5A0Z",
"icd10_code": "E07",
"icd10_title": "Other disorders of thyroid"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E078",
"icd10_title": "Other specified disorders of thyroid"
},
{
"from_icd11": "5A0Z",
"icd10_code": "E35",
"icd10_title": "Disorders of endocrine glands in diseases classified elsewhere"
},
{
"from_icd11": "5A00.2Z",
"icd10_code": "E033",
"icd10_title": "Postinfectious hypothyroidism"
},
{
"from_icd11": "5A03.0",
"icd10_code": "E060",
"icd10_title": "Acute thyroiditis"
}
] |
E069
|
Thyroiditis, unspecified
|
The patient had a disease course of 15 months, and his clinical manifestations were difficulty lifting, muscle fibrillation in both upper limbs, and atrophy of the upper arm muscles, scapular girdle muscles, supraspinatus, infraspinatus, and palmar muscles. The EMG indicated neurogenic damage in both upper limbs, mainly involving proximal muscles, no involvement of the lower limbs, and no obvious bulbar damage, consistent with FAS. The main consideration was to distinguish FAS from progressive muscular atrophy, facioscapulohumeral muscular dystrophy, cervical spondylotic myelopathy, and brachial plexus neuropathy; Progressive muscular atrophy: Progressive muscular atrophy mainly involves the motor neurons of the anterior horn of the spinal cord. The disease onset mostly occurs between the ages of 40 and 50 years. The disease occurs more among males than among females and often progresses slowly. Its manifestations include muscle weakness, muscle atrophy, muscle fasciculation, and other signs and symptoms of lower motor neuron dysfunction in limbs. The first symptoms of progressive muscular atrophy are usually atrophy and weakness of the small muscles in 1 or both hands, gradually involving the forearms, upper arms, and scapular girdle muscles. Atrophy starting from the lower limbs is uncommon. Patients with progressive muscular atrophy typically have marked distal atrophy and decreased muscle tone and tendon reflexes but no sensory disturbance or sphincter involvement. This patient had evident proximal muscle atrophy, a positive Rosso limo sign in the right upper limb, and evidence of upper motor neuron damage, which are not fully consistent with the diagnosis of progressive muscular atrophy; Facioscapulohumeral muscular dystrophy: Facioscapulohumeral muscular dystrophy is a genetic muscle disorder that mainly affects the facial muscles and scapular girdle muscles and gradually affects the trunk and pelvic girdle muscles. Disease onset mostly occurs in adolescence, and disease progression is generally slow, without affecting the lifespan of patients. The first symptom in patients with facioscapulohumeral muscular dystrophy is shoulder muscle weakness, which manifests as a “winged scapula.” In the early stage of the disease, patients often show difficulty throwing. This patient had difficulty completing actions such as brushing his hair, washing his face, and lifting objects, primarily due to aggravation of proximal upper limb muscle weakness. He also had a slightly elevated serum creatine kinase level. However, the age and neurogenic damage (no myogenic damage indicated by EMG) of this patient did not support the diagnosis of facioscapulohumeral muscular dystrophy; Cervical spondylotic myelopathy: Cervical spondylotic myelopathy is mainly due to the degeneration of the intervertebral joints. Disease onset generally occurs between the ages of 40 and 60 years. Its manifestations may include motor or sensory dysfunction (such as radicular pain) and sphincter dysfunction. Although most patients with cervical spondylitis myelopathy have a long disease course, they may experience rapid disease progression. Strenuous exercise will aggravate the compression of the spinal cord and even affect the function of the spinal cord in severe cases. This patient had no obvious radicular pain or sensory disturbance. Hence, the clinical evidence did not support the diagnosis of cervical spondylotic myelopathy; Brachial plexus neuropathy: Most of the anterior branches of the C5 to T1 spinal nerves constitute the brachial plexus, which travels through the interscalene space and then the subclavian artery to enter the axillary cavity through the back of the clavicle. The common clinical manifestations of brachial plexus neuropathy are drooping upper limbs, adducted upper arms, inability to abduct or externally rotate the upper arms, adducted, and straightened forearms, inability to pronate, supinate or bend the forearms, preserved hand and finger motor functions, and constant sensory disturbances in the scapulae, upper arms, and lateral forearms. Similar symptoms to FAS include bilateral brachial plexopathy. However, brachial plexus neuropathy still could not explain the lack of sensory disturbance, and the progressive aggravation of symptoms in this patient. FAS can be easily distinguished from multifocal motor neuropathy, anterior spinal artery syndrome, Hirayama disease, paraneoplastic syndrome, and neuropathy caused by connective tissue disease. Because FAS patients aged 40 to 60 years are often complicated with cervical degenerative changes and spinal cord compression, they are easily misdiagnosed with cervical spondylotic myelopathy. If these patients receive surgery for cervical spondylotic myelopathy, they will suffer more pain and economic loss. In contrast, the misdiagnosis of other curable diseases or slow-progressing diseases as FAS can delay treatment. Therefore, it is necessary to strengthen our understanding of FAS, Furthermore, the relatively slow progression of the disease also helps patients eliminate the fear of ALS.
| 4.328125
| 0.90918
|
sec[2]/sec[2]/p[0]
|
en
| 0.999998
|
PMC10118368
|
https://doi.org/10.1097/MD.0000000000033565
|
[
"atrophy",
"muscular",
"muscle",
"muscles",
"cervical",
"patients",
"myelopathy",
"limbs",
"spondylotic",
"brachial"
] |
[
{
"code": "FB32.Y",
"title": "Other specified disorders of muscles"
},
{
"code": "BE2Y",
"title": "Other specified diseases of the circulatory system"
},
{
"code": "CB40.Y",
"title": "Other specified diseases of the respiratory system"
},
{
"code": "9C40.BZ",
"title": "Optic atrophy, unspecified"
},
{
"code": "8E7Y",
"title": "Other specified diseases of the nervous system"
},
{
"code": "FB3Z",
"title": "Disorders of muscles, unspecified"
},
{
"code": "8C70.Z",
"title": "Muscular dystrophy, unspecified"
},
{
"code": "FB32.2Z",
"title": "Ischaemic infarction of muscle, unspecified"
},
{
"code": "FB56.2",
"title": "Myalgia"
},
{
"code": "GA04",
"title": "Cervicitis"
}
] |
=== ICD-11 CODES FOUND ===
[FB32.Y] Other specified disorders of muscles
Also known as: Other specified disorders of muscles | Muscle wasting or atrophy, not elsewhere classified | muscle wasting | muscle wasting disorder | Sarcopenia
[BE2Y] Other specified diseases of the circulatory system
Also known as: Other specified diseases of the circulatory system | Certain specified forms of heart disease | Cardiac disorder, unspecified | disorder of heart NOS | organic disease or disorder of heart
[CB40.Y] Other specified diseases of the respiratory system
Also known as: Other specified diseases of the respiratory system | Secondary respiratory disorders | Respiratory disorders in diseases classified elsewhere | Diseases of bronchus, not elsewhere classified | Acquired bronchial diverticulum
[9C40.BZ] Optic atrophy, unspecified
Also known as: Optic atrophy, unspecified | Optic atrophy | optic nerve atrophy | Primary optic atrophy | OA - [optic atrophy]
[8E7Y] Other specified diseases of the nervous system
Also known as: Other specified diseases of the nervous system | Circumscribed brain atrophy | circumscribed cerebral atrophy | atrophic lobar sclerosis | atrophic lobar brain sclerosis
[FB3Z] Disorders of muscles, unspecified
Also known as: Disorders of muscles, unspecified | disorder of muscle, unspecified | muscle disease | muscular disease | muscular disorder
[8C70.Z] Muscular dystrophy, unspecified
Also known as: Muscular dystrophy, unspecified | Muscular dystrophy | Gower's muscular dystrophy | progressive musclular dystrophy | pseudohypertrophic atrophy
[FB32.2Z] Ischaemic infarction of muscle, unspecified
Also known as: Ischaemic infarction of muscle, unspecified | Ischaemic infarction of muscle | muscle infarction
[FB56.2] Myalgia
Definition: This is a disorder characterised by pain in a muscle or group of muscles.
Also known as: Myalgia | muscle ache | muscle soreness | muscular pain | myalgic
Excludes: Chronic primary musculoskeletal pain | Chronic secondary musculoskeletal pain
[GA04] Cervicitis
Also known as: Cervicitis | inflammation of cervix | inflammation of cervix uteri | Ulcer of cervix with cervicitis | Acute cervicitis
=== GRAPH WALKS ===
--- Walk 1 ---
[FB32.Y] Other specified disorders of muscles
--PARENT--> [FB32] Certain specified disorders of muscle
Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....
--EXCLUDES--> [?] Alcoholic myopathy
Def: Myopathy secondary to alcohol use and includes acute and chronic alcoholic myopathy. Several forms have been described: acute necrotizing myopathy, acute hypokalaemic myopathy, chronic alcoholic myopa...
--- Walk 2 ---
[FB32.Y] Other specified disorders of muscles
--PARENT--> [FB32] Certain specified disorders of muscle
Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....
--EXCLUDES--> [?] Alcoholic myopathy
Def: Myopathy secondary to alcohol use and includes acute and chronic alcoholic myopathy. Several forms have been described: acute necrotizing myopathy, acute hypokalaemic myopathy, chronic alcoholic myopa...
--- Walk 3 ---
[BE2Y] Other specified diseases of the circulatory system
--PARENT--> [11] Diseases of the circulatory system
Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...
--PARENT--> [?] ICD-11 for Mortality and Morbidity Statistics
--- Walk 4 ---
[BE2Y] Other specified diseases of the circulatory system
--PARENT--> [11] Diseases of the circulatory system
Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...
--RELATED_TO--> [?] Functional vascular disorders of the skin
Def: Skin disorders due to disturbances in vascular tone and skin blood flow....
--- Walk 5 ---
[CB40.Y] Other specified diseases of the respiratory system
--PARENT--> [CB40] Certain diseases of the respiratory system
--CHILD--> [CB40.0] Ciliary dyskinesia
Def: Defective function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) resulting in altered mucociliary transport and manifesting as recurrent upper and l...
--- Walk 6 ---
[CB40.Y] Other specified diseases of the respiratory system
--PARENT--> [CB40] Certain diseases of the respiratory system
--RELATED_TO--> [?] Pulmonary sporotrichosis
Def: Pulmonary forms of infection, although uncommon, can occur when Sporothrix schenckii conidia are inhaled.
Symptoms of pulmonary sporotrichosis mimic those of tuberculosis including constitutional com...
|
[
"[FB32.Y] Other specified disorders of muscles\n --PARENT--> [FB32] Certain specified disorders of muscle\n Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....\n --EXCLUDES--> [?] Alcoholic myopathy\n Def: Myopathy secondary to alcohol use and includes acute and chronic alcoholic myopathy. Several forms have been described: acute necrotizing myopathy, acute hypokalaemic myopathy, chronic alcoholic myopa...",
"[FB32.Y] Other specified disorders of muscles\n --PARENT--> [FB32] Certain specified disorders of muscle\n Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....\n --EXCLUDES--> [?] Alcoholic myopathy\n Def: Myopathy secondary to alcohol use and includes acute and chronic alcoholic myopathy. Several forms have been described: acute necrotizing myopathy, acute hypokalaemic myopathy, chronic alcoholic myopa...",
"[BE2Y] Other specified diseases of the circulatory system\n --PARENT--> [11] Diseases of the circulatory system\n Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...\n --PARENT--> [?] ICD-11 for Mortality and Morbidity Statistics",
"[BE2Y] Other specified diseases of the circulatory system\n --PARENT--> [11] Diseases of the circulatory system\n Def: This refers to diseases of the organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases...\n --RELATED_TO--> [?] Functional vascular disorders of the skin\n Def: Skin disorders due to disturbances in vascular tone and skin blood flow....",
"[CB40.Y] Other specified diseases of the respiratory system\n --PARENT--> [CB40] Certain diseases of the respiratory system\n --CHILD--> [CB40.0] Ciliary dyskinesia\n Def: Defective function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) resulting in altered mucociliary transport and manifesting as recurrent upper and l...",
"[CB40.Y] Other specified diseases of the respiratory system\n --PARENT--> [CB40] Certain diseases of the respiratory system\n --RELATED_TO--> [?] Pulmonary sporotrichosis\n Def: Pulmonary forms of infection, although uncommon, can occur when Sporothrix schenckii conidia are inhaled. \nSymptoms of pulmonary sporotrichosis mimic those of tuberculosis including constitutional com..."
] |
FB32.Y
|
Other specified disorders of muscles
|
[
{
"from_icd11": "FB32.Y",
"icd10_code": "M6281",
"icd10_title": "Muscle weakness (generalized)"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H47213",
"icd10_title": "Primary optic atrophy, bilateral"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H47291",
"icd10_title": "Other optic atrophy, right eye"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H47292",
"icd10_title": "Other optic atrophy, left eye"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H4720",
"icd10_title": "Unspecified optic atrophy"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H4722",
"icd10_title": "Hereditary optic atrophy"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H47239",
"icd10_title": "Glaucomatous optic atrophy, unspecified eye"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H472",
"icd10_title": "Optic atrophy"
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H48",
"icd10_title": ""
},
{
"from_icd11": "9C40.BZ",
"icd10_code": "H480",
"icd10_title": ""
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60831",
"icd10_title": "Other myositis, right forearm"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60869",
"icd10_title": "Other myositis, unspecified lower leg"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60811",
"icd10_title": "Other myositis, right shoulder"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6080",
"icd10_title": "Other myositis, unspecified site"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60851",
"icd10_title": "Other myositis, right thigh"
}
] |
M6281
|
Muscle weakness (generalized)
|
The patient was a 76-year-old healthy male who was admitted to the hospital due to persistent cough and fever for six days, which worsened on the day of admission. Six days before admission, he began to experience cough and high fever (39.5°C), along with chest tightness after activity, but did not seek immediate medical attention. Three days before admission, his symptoms worsened, and he visited a local hospital. Chest CT scans revealed scattered infectious lesions in both lungs. Despite receiving anti-infective treatments with moxifloxacin and piperacillin sodium tazobactam sodium, his symptoms did not improve, and routine etiological examinations did not yield any positive results. Treatment was then switched to imipenem-cilastatin sodium, but the patient’s condition did not improve and he experienced shortness of breath with a continuous decline in blood oxygen saturation. Consequently, he underwent tracheal intubation and was transferred to our hospital’s emergency department. Figure 1 is a timeline of the clinical condition progress and major management of the patient. The patient has no history of hypertension, diabetes, lung disease, AIDS, or other immunodeficiency diseases, no history of long-term medication use, no history of smoking or alcohol consumption, and engages in farming and raising chickens and ducks at home. Laboratory tests revealed arterial blood gas analysis (using 100% oxygen concentration) results: partial pressure of carbon dioxide 33.0mmHg, oxygen partial pressure 55.8mmHg, base excess −4.4 mmol/L, blood glucose 13.50 mmol/L, lactate 2.0 mmol/L; CRP 241.53 mg/L, white blood cell count 16.8 × 10^9/L, neutrophils 97.4%, lymphocytes 1.1%. Emergency coagulation function tests showed fibrinogen 8.40g/L, partial thromboplastin time 43.2 seconds, D-dimer 11.41mg/L, antithrombin III 67.3%. Chest X-ray indicated multifocal infections in both lungs, with large areas of consolidation, more pronounced in the right lung, and bilateral pleural effusion. The patient was admitted with a diagnosis of “severe pneumonia, acute respiratory failure.” Physical examination upon admission showed a temperature of 37.8°C, heart rate 98 beats per minute, respiratory rate 24 breaths per minute, blood pressure 131/98 mmHg, and weight 45kg, APACHE II score was 15 points. On the day of admission, the patient received intravenous infusion of imipenem-cilastatin sodium (1 g every 8 h) and moxifloxacin (0.4 g daily) for anti-infection treatment. Additionally, a bronchoalveolar lavage fluid sample was collected for metagenomic next-generation sequencing. Under the AC/PC mode of the ventilator (oxygen concentration 100%, respiratory rate 15 breaths per minute, tidal volume 400 mL, positive end-expiratory pressure 15.0 cmH 2 O), blood gas analysis showed a partial pressure of oxygen of 40 mmHg and an oxygenation index of 40. We recommended veno-venous extracorporeal membrane oxygenation (VV-ECMO) treatment for the patient, but his family declined due to financial reasons. Therefore, we opted for prone positioning ventilation. Two hours later, blood gas analysis showed a significant improvement in the patient’s oxygenation index to 80. On the fourth day of hospitalization, metagenomic next-generation sequencing results indicated a positive Chlamydia abortus infection . Considering the significant improvement in CRP, procalcitonin, and oxygenation index, we discontinued imipenem-cilastatin sodium and switched to piperacillin-tazobactam (4.5 g every 8 h) combined with moxifloxacin (0.4g daily) for anti-infection treatment and temporarily stopped prone positioning ventilation. However, on the eighth day of hospitalization, the patient exhibited increased airway secretions and a decline in oxygenation index, prompting a repeat chest CT scan and intermittent prone positioning ventilation. At the same time, we recollected bronchoalveolar lavage fluid for metagenomic next-generation sequencing analysis. During treatment, the patient’s symptoms and indicators significantly improved. Finally, on the tenth day of hospitalization, the patient successfully underwent tracheal extubation and was switched to high-flow non-invasive respiratory humidification treatment. On the eleventh day, metagenomic next-generation sequencing results showed Chlamydia abortus infection combined with Corynebacterium striatum infection , leading to a change in treatment to moxifloxacin (0.4g daily) combined with linezolid (0.6g every 12 h) for anti-infection treatment. After treatment, the patient’s inflammatory markers improved , oxygenation index increased , lung inflammation resolved , and he was successfully transferred out of the ICU on the sixteenth day of hospitalization. The patient’s symptoms continuously improved during hospitalization, and after a period of treatment and rehabilitation, his condition stabilized, and he was transferred back to the local hospital for continued treatment. One month later, during a follow-up visit, his respiratory symptoms had almost disappeared, and chest imaging showed significant absorption and improvement .
| 3.841797
| 0.97998
|
sec[1]/p[0]
|
en
| 0.999999
|
39328319
|
https://doi.org/10.3389/fmed.2024.1428300
|
[
"blood",
"infection",
"oxygenation",
"chest",
"sodium",
"oxygen",
"pressure",
"respiratory",
"index",
"hospitalization"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "1H0Z",
"title": "Infection, unspecified"
},
{
"code": "1G40",
"title": "Sepsis without septic shock"
},
{
"code": "FA10.Z",
"title": "Direct infections of joint, unspecified"
},
{
"code": "1D9Z",
"title": "Unspecified viral infection of unspecified site"
},
{
"code": "1A40.Z",
"title": "Infectious gastroenteritis or colitis without specification of infectious agent"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[1H0Z] Infection, unspecified
Also known as: Infection, unspecified | infection NOS | infectious disease NOS | infection unknown | infection process NOS
[1G40] Sepsis without septic shock
Definition: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Also known as: Sepsis without septic shock | sepsis without septic shock with known organism | Sepsis-associated hypotension | Unspecified sepsis | general septic intoxication
Excludes: Septicaemia | Sepsis of fetus or newborn
[FA10.Z] Direct infections of joint, unspecified
Also known as: Direct infections of joint, unspecified | Direct infections of joint | septic arthritis | pyogenic arthritis | arthritis due to infection
[1D9Z] Unspecified viral infection of unspecified site
Also known as: Unspecified viral infection of unspecified site | viral infection NOS | viral disorder NOS | disease caused by virus | unspecified viremia
[1A40.Z] Infectious gastroenteritis or colitis without specification of infectious agent
Also known as: Infectious gastroenteritis or colitis without specification of infectious agent | Gastroenteritis or colitis without specification of infectious agent | diarrhoea and gastroenteritis of presumed infectious origin | diarrhoeal enteritis | GE - [gastroenteritis]
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues
Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues
Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.40] Macroscopic haematuria
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--EXCLUDES--> [?] Recurrent or persistent glomerular haematuria
Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.0] Finding of opiate drug in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues\n Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --RELATED_TO--> [?] Neoplasms of haematopoietic or lymphoid tissues\n Def: A neoplasm arising from hematopoietic or lymphoid cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic or lymphoid system). Hematopoietic or lymphoid c...",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.40] Macroscopic haematuria",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --EXCLUDES--> [?] Recurrent or persistent glomerular haematuria\n Def: The presence in the urine of glomerular origin red blood cells (RBCs). In microscopic haematuria the urine appears normal to the naked eye, but examination with a microscope shows a high number of RBC...",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.0] Finding of opiate drug in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
A 64-old male Han Chinese was admitted due to acute onset of the right lower limb paralysis, paresthesia and urinary incontinence, preceded by six-month history of lower back pain and numbness in lower limbs, and urinary incontinence. Five years prior to the current presentation, he had the ascending left lower extremity weakness and numbness, but progressed extremely rapidly (in five days) resulting in gait instability, band-like sensory deficits, and accompanied by progressive loss of vision in the left eye initially, subsequently developed loss of vision in the right eye 2 months later. For 3 years, he had experienced refractory gastrointestinal symptoms, including nausea, vomiting, epigastric pain and early satiety. No history of skin rashes, photosensitivity, arthralgia, hair loss, oral ulcers, and recurrent fever, joint arthritis and erythema nodosum was identified. On specific questioning, he experienced a sensation in both eyes and a dry mouth since the past 2 months. This time, His vision was normal with no visual field defects or double images, and no optic atrophy or optic neuritis was detected on fundoscopy. Physical examination revealed normal vital signs, heart, lungs and abdominal examination. Cranial nerve examination was normal. Sensory examination revealed loss of pain sensation and tactile sensation (grade 1), displayed deficits in proprioception and touch sensation in the lower extremities (grade 1), Motor examination showed motor strength grade 1/5 and 4/5 in the right and left lower limb right respectively, Pain and temperature sensation was diminished to T4, light touch was mildly impaired to T4, vibration decreased to the knee on the right. Abdominal reflexes were absent, and tendon reflexes were equivocal. Babinski’s sign were present bilaterally, Kernig’s sign and Brudzinski’s sign were negative. Full blood counts, electrolytes, complement, kidney and liver functions, thyroid function, homocystein, Vitamin B12 Vitamin D, Vitamin B1, Complement C3, Complement C4, urinalysis results were all within normal limits. Other antibodies including rheumatoid factor (RF), anti-streptolysin “O”, thyroid-associated antibodies, ENA, anti-Sm, anti-Scl70, anti-Jo-1, anti-dsDNA, anti-centromere, anti-nucleosome, anti-histone, anti-ribosomal P protein antibodies, c-ANCA, p-ANCA, Anti-dsDNA were negative, Other laboratory datas including Lyme IgM, IgG, IgA, VDRL, HSV, VZV, CMV, EBV, HBV, HCV, HIV in serum and CSF were negative. Angiotensin-converting enzyme (ACE) were negative, Kveim test was negative. Abnormal laboratory findings included ESR 70 mm (< 20 mm), CRP 46 mg/l (< 20 mg/l), ANA + 1:640 [< 1:160; indirect immunofluorescence (IIF) on Hep2 cells], Anti-Sjögren’s syndrome A (SSA)/Ro, anti-Sjögren’s syndrome B (SSB)/La 1:4 [(0); double immunodiffusion assay]. Serum anti-aquaporin-4 antibody 1:320 [(0) (AQP4-Ab; AQP4-Ab was detected by indirect immunofluorescence staining using human AQP4 transfected HEK 293 cells, by a cellbased assay; CBA), This had been recommended in International consensus diagnostic criteria for neuromyelitis optica spectrum disorders)] . Cerebrospinal fluid analysis revealed opening pressure 120 mmH2O (70–180 mmH2O), white cell count 13 cells/μl (0–5 cells/μl), total protein: 0.26 g/l (0.15–0.45 g/l), glucose: 3.76 mmol/L (2.5–4.4 mmol/L), chloride: 119.4 mmol/L (120–130 mmol/L). Cerebrospinal fluid analysis showed negative oligoclonal bands (OCB) by isoelectric focusing (IEF) on agarose gels followed by immunoblotting using an IgG-specific antibody staining. Schirmer’s I test showed normal lacrimal flow (> 15 mm at 5 min). CT chest/abdomen/pelvis was done which did not revealed bilateral hilar and mediastinal lymphadenopathy. Brain magnetic resonance imaging (MRI) did not show pathologic lesions. Spine MRI revealed syringomyelia from C7 to T4 . Salivary scintigraphy showed bilateral submandibular and parotid gland excretion were impaired and bilateral submandibular gland uptake were slightly impaired. Lip biopsies were performed, the consisting of two lesions had exhibited greater than 50 lymphocytes in 4 cm3 along with focal lymphoctic infiltration, which was suggestive of pSS . Fig. 1 Serum anti-aquaporin-4 antibody CBA Fig. 2 Disease course, MRI scans and therapy in the SM-like syndrome in NMOSD complicated with SS. The figure depicts clinical relapses (triangle), MRI findings (T2WI, T2 fs FSE, T2WI, T1WI, T2 fs FSE), and therapy data (methyl prednisolone (MP) 1000 mg ivdrip. 3–5 daily infusions; prednisone (pred) 60 mg orally daily with gradual taper; Azathioprine(AZA) was increased from 50 mg to 100 mg daily. AQP: aquaporin, AZA: azathioprine, FLAIR: fluid attenuated inversion recovery, MP: methyl prednisolone, pred: prednisone, MRI: magnetic resonance imaging, NMOSD: neuromyelitis optica spectrum disorder, SM: syringomyelia, SS: Sjogren syndrome Fig. 3 Histological analysis of salivary gland biopsies. Biopsies were stained using hematoxylin-eosin, Magnification: 400×, A and B are pointing to lymphocytic and plasma cell infiltration, loss of salivary gland parenchyma
| 4.039063
| 0.979004
|
sec[1]/p[0]
|
en
| 0.999997
|
30301458
|
https://doi.org/10.1186/s12883-018-1170-9
|
[
"anti",
"loss",
"sensation",
"pain",
"cells",
"mmol",
"gland",
"vision",
"including",
"grade"
] |
[
{
"code": "JA86.Y",
"title": "Maternal care for other specified fetal problems"
},
{
"code": "MB23.1",
"title": "Antisocial behaviour"
},
{
"code": "3B4Z",
"title": "Coagulation defects, unspecified"
},
{
"code": "4A45.Z",
"title": "Antiphospholipid syndrome, unspecified"
},
{
"code": "4A43.Y",
"title": "Other specified overlap non-organ specific systemic autoimmune disease"
},
{
"code": "FB32.Y",
"title": "Other specified disorders of muscles"
},
{
"code": "QE61.0",
"title": "Loss or death of child"
},
{
"code": "5C70.0",
"title": "Dehydration"
},
{
"code": "MB27.Z",
"title": "Symptoms or signs of perceptual disturbance, unspecified"
},
{
"code": "MG43.5",
"title": "Excessive weight loss"
}
] |
=== ICD-11 CODES FOUND ===
[JA86.Y] Maternal care for other specified fetal problems
Also known as: Maternal care for other specified fetal problems | Maternal care for other isoimmunization | Isoimmunization NOS | maternal antibodies NOS | pregnancy management affected by incompatibility of blood groups NOS
[MB23.1] Antisocial behaviour
Definition: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated.
Also known as: Antisocial behaviour | Child or adolescent antisocial behaviour
[3B4Z] Coagulation defects, unspecified
Also known as: Coagulation defects, unspecified | blood clotting disturbance | blood clotting defect | blood clotting factor deficiency | clotting abnormality
[4A45.Z] Antiphospholipid syndrome, unspecified
Also known as: Antiphospholipid syndrome, unspecified | Antiphospholipid syndrome | Hughes syndrome | Anticardiolipin syndrome
[4A43.Y] Other specified overlap non-organ specific systemic autoimmune disease
Also known as: Other specified overlap non-organ specific systemic autoimmune disease | Antisynthetase syndrome | Reynolds syndrome | Syndromic multisystem autoimmune disease due to ITCH deficiency | Eosinophilia myalgia syndrome
[FB32.Y] Other specified disorders of muscles
Also known as: Other specified disorders of muscles | Muscle wasting or atrophy, not elsewhere classified | muscle wasting | muscle wasting disorder | Sarcopenia
[QE61.0] Loss or death of child
Also known as: Loss or death of child | loss of child | death of child
Excludes: Prolonged grief disorder
[5C70.0] Dehydration
Definition: Dehydration occurs when there is an insufficient amount or excessive loss of water in the body. This can be caused by vomiting, diarrhoea, fever, use of diuretics, profuse sweating, or decreased water intake.
Also known as: Dehydration | fluid depletion | anhydration | anhydremia | fluid volume deficit
[MB27.Z] Symptoms or signs of perceptual disturbance, unspecified
Also known as: Symptoms or signs of perceptual disturbance, unspecified | Symptoms or signs involving perceptual disturbance | sensory loss
[MG43.5] Excessive weight loss
Definition: A reduction of total body mass, due to loss of fluid, body fat or adipose tissue, or lean (muscle) mass that is sufficient in quantity or rate to create risk to the individual’s health.
Also known as: Excessive weight loss | abnormal decrease in weight | abnormal weight loss | unintended weight loss | weight loss NOS
=== GRAPH WALKS ===
--- Walk 1 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--EXCLUDES--> [?] Placental transfusion syndromes
--- Walk 2 ---
[JA86.Y] Maternal care for other specified fetal problems
--PARENT--> [JA86] Maternal care for other fetal problems
Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....
--CHILD--> [JA86.1] Maternal care for hydrops fetalis
--- Walk 3 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--CHILD--> [MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--- Walk 4 ---
[MB23.1] Antisocial behaviour
Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....
--PARENT--> [MB23] Symptoms or signs involving appearance or behaviour
--RELATED_TO--> [?] Speech dysfluency
Def: Speech dysfluency is characterised by the frequent or pervasive disruption of the rhythmic flow of speech that arises subsequent to the developmental period (i.e., adult onset) and is outside the limi...
--- Walk 5 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--PARENT--> [?] Coagulation defects, purpura or other haemorrhagic or related conditions
Def: A condition caused by determinants arising during the antenatal period, after birth or by genetically inherited factors, leading to coagulation defects. This condition is characterised by increased br...
--- Walk 6 ---
[3B4Z] Coagulation defects, unspecified
--PARENT--> [?] Coagulation defects
--CHILD--> [?] Haemorrhagic diseases due to acquired coagulation factor defects
Def: Any disease caused by determinants arising after birth. These diseases are characterised by abnormal coagulation of the blood....
|
[
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --EXCLUDES--> [?] Placental transfusion syndromes",
"[JA86.Y] Maternal care for other specified fetal problems\n --PARENT--> [JA86] Maternal care for other fetal problems\n Def: A condition characterised by the provision of health interventions to the mother due to any other issue that is either suspected or known to be present in the fetus....\n --CHILD--> [JA86.1] Maternal care for hydrops fetalis",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --CHILD--> [MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....",
"[MB23.1] Antisocial behaviour\n Def: Behaviour in which the basic rights of others or major age-appropriate societal norms, rules, or laws, are violated....\n --PARENT--> [MB23] Symptoms or signs involving appearance or behaviour\n --RELATED_TO--> [?] Speech dysfluency\n Def: Speech dysfluency is characterised by the frequent or pervasive disruption of the rhythmic flow of speech that arises subsequent to the developmental period (i.e., adult onset) and is outside the limi...",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --PARENT--> [?] Coagulation defects, purpura or other haemorrhagic or related conditions\n Def: A condition caused by determinants arising during the antenatal period, after birth or by genetically inherited factors, leading to coagulation defects. This condition is characterised by increased br...",
"[3B4Z] Coagulation defects, unspecified\n --PARENT--> [?] Coagulation defects\n --CHILD--> [?] Haemorrhagic diseases due to acquired coagulation factor defects\n Def: Any disease caused by determinants arising after birth. These diseases are characterised by abnormal coagulation of the blood...."
] |
JA86.Y
|
Maternal care for other specified fetal problems
|
[
{
"from_icd11": "JA86.Y",
"icd10_code": "O26841 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26843 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O26849 ",
"icd10_title": ""
},
{
"from_icd11": "JA86.Y",
"icd10_code": "O3680X0 ",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D688",
"icd10_title": "Other specified coagulation defects"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D689",
"icd10_title": "Coagulation defect, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D699",
"icd10_title": "Hemorrhagic condition, unspecified"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D698",
"icd10_title": "Other specified hemorrhagic conditions"
},
{
"from_icd11": "3B4Z",
"icd10_code": "D65-D69",
"icd10_title": ""
},
{
"from_icd11": "3B4Z",
"icd10_code": "D69",
"icd10_title": "Purpura and other hemorrhagic conditions"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6861",
"icd10_title": "Antiphospholipid syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6869",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D6862",
"icd10_title": "Lupus anticoagulant syndrome"
},
{
"from_icd11": "4A45.Z",
"icd10_code": "D686",
"icd10_title": "Other thrombophilia"
},
{
"from_icd11": "FB32.Y",
"icd10_code": "M6281",
"icd10_title": "Muscle weakness (generalized)"
}
] |
O26841
| |
The present case illustrates a rare example of an intraosseous hemangioma, which has been well-documented with respect to its interdisciplinary treatment and its follow-up history. In the current case, the diagnostic finding was an incidental finding after fabrication of a panoramic x-ray. In 2007, the patient firstly attained knowledge of an intrabony osteolytic process in the left mandible. At that time point as well as ten years later, both panoramic radiographs showed a homogeneous, unilocular, well-defined osteolytic lesion. This is in contrast to the radiological appearance of most of the intraosseous hemangiomas, which is described as soap bubble, honeycomb-like appearance, a sunray appearance, caused by bony trabeculae in the lesion or a poorly defined osteolytic lesion . The variable appearance of central hemangioma in different projections was also described . Differential diagnosis of for example aneurysmal bone cyst, fibrous dysplasia, ameloblastoma, osteoma, osteosarcoma, giant cell lesion, residual cyst, multiple myeloma, and myxoma could not be radiographically distinguished . Therefore, it is not possible to diagnose an intraosseous hemangioma based on dental radiology alone. Clinical findings are also varying. Many patients do not report about any symptoms, as described in the current case. But bony swellings of different size, sometimes causing asymmetry of the face, paraesthesia of lips as well as the mental region, pulsation or discomfort can occur as well [ 12 , 18 – 20 ]. Symptoms regarding teeth and the alveolar process such as bluish discoloration of the gingiva, mobile or displaced teeth, agenesis of teeth, alteration of the dental arch or seeping gingival bleeding which were also described, were not found in the present case. Moreover, the patient did not report about early eruption of the permanent teeth, which could also be related to central hemangiomas of the jaw [ 11 , 18 , 21 – 24 ]. Osteolytic lesions that are of extraordinary or inexplicable origin, as depicted in the current case, should be biopsied and clarified . From a critical point of view, advantages of intraoperative biopsies are to be contrasted with the disadvantages of the same. The main advantage of a biopsy is seen in the histological verification of a diagnosis. The so collected details allow a precise surgical procedure according to the respective pathology. As a possible disadvantage of a biopsy, severe complications could result from the lack of knowledge regarding the lesion. For instance, if an intraosseous hemangioma is present like in the present case and a biopsy would have been taken, serious complications in form of severe bleeding would be possible during surgery or diagnostic confirmation. It was described that patients died after extractions of teeth with hemangioma association or even after puncture biopsy of a hemangioma of the jaw . For this reason, it is important to be as careful as possible during surgery and to gently remove every tissue layer, without touching the lesion itself, as it was performed in the current situation. The vestibular access provided an optimal overview and allowed to depict the mental foramen for estimation of the mandibular nerve pathway. This was also necessary to protect the mental nerve. If hemangiomas, especially extensive ones, are expected because of radiological appearance and clinical signs, angiography before surgery could be a very useful tool for detecting feeding vessels and planning the approach of therapy . In the present case, it was assumed that the lesion would be a sort of cyst. Accordingly, there was no need to apply angiography. Treatment options that provide complete histopathological investigation reach from partial mandibuloectomy to minimally invasive approaches such as curettage or surgical removal of the lesion with or without ligation or embolization of the feeding vessels . The option, to omit any invasive intervention, in particular, in the present case could have led to root resorptions of neighboring teeth , a compression of the inferior alveolar nerve accompanied by paresthesia or pain, and a further expansion to the mental foramen, where a removal would be much more complicated or a reduction of the lower jaw stability . However, since the patient was originally asymptomatic for more than ten years, it was an option to left the lesion untreated . Indeed, the consequence, to clarify the diagnosis of the lesion, relied on the fact, that the inferior alveolar nerve was not detectable within the CBCT. The plan of sample taking in order to histologically verify the most probable diagnosis of an infected radicular cyst, was rejected intraoperatively based on the atypical appearance of the lesion. Instead, the decision was made to completely remove the lesion, carefully as recommended by other authors .In the present case, the size of the mass as well as its texture allowed for a gentle procedure resulting in a preservation of teeth and the mental nerve resulting in a nearly four years follow-up without recurrence of the intraosseous lesion.
| 4.261719
| 0.901367
|
sec[5]/p[0]
|
en
| 0.999998
|
36639813
|
https://doi.org/10.1186/s13005-022-00346-x
|
[
"lesion",
"present",
"teeth",
"hemangioma",
"well",
"that",
"appearance",
"intraosseous",
"mental",
"nerve"
] |
[
{
"code": "FA5Z",
"title": "Arthropathies, unspecified"
},
{
"code": "FC0Z",
"title": "Diseases of the musculoskeletal system or connective tissue, unspecified"
},
{
"code": "ME60.Z",
"title": "Skin lesion of unspecified nature"
},
{
"code": "MD41",
"title": "Clinical findings on diagnostic imaging of lung"
},
{
"code": "GC2Z&XA6KU8",
"title": "Disease of kidney, not elsewhere classified"
},
{
"code": "JA82.2",
"title": "Maternal care for transverse or oblique lie"
},
{
"code": "JA82.1",
"title": "Maternal care for breech presentation"
},
{
"code": "JA82.Z",
"title": "Maternal care for malpresentation of fetus, unspecified"
},
{
"code": "JA82.6",
"title": "Maternal care for compound presentation"
},
{
"code": "JA82.5",
"title": "Maternal care for multiple gestation with malpresentation of one fetus or more"
}
] |
=== ICD-11 CODES FOUND ===
[FA5Z] Arthropathies, unspecified
Also known as: Arthropathies, unspecified | Disorders affecting predominantly peripheral joints | Disorders affecting predominantly peripheral limb joints | arthropathy NOS | arthropathic
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
Also known as: Diseases of the musculoskeletal system or connective tissue, unspecified | bone disease NOS | bone disorder NOS | bone lesion NOS | musculoskeletal complications NOS
[ME60.Z] Skin lesion of unspecified nature
Also known as: Skin lesion of unspecified nature | Skin lesion of uncertain or unspecified nature | Skin lesion without established diagnosis | Pigmented skin lesion of unspecified nature | Ulcer of skin of unspecified nature
[MD41] Clinical findings on diagnostic imaging of lung
Definition: Clinical findings on diagnostic imaging of lung is findings on diagnostic imaging of the lung which don't appear in normal status of the body. Diagnostic imaging refers to technologies that doctors use to look inside body for clues about a medical condition. X-rays, CT scans, nuclear medicine scans, MRI scans and ultrasound are all types of diagnostic imaging.
Also known as: Clinical findings on diagnostic imaging of lung | abnormal diagnostic imaging of lung | Hyperinflation of lung | Lung mass | Pulmonary lobe mass
[JA82.2] Maternal care for transverse or oblique lie
Also known as: Maternal care for transverse or oblique lie | Maternal care for oblique presentation | Maternal care for prolapse of arm or hand | Maternal care for transverse presentation of fetus | transverse presentation
[JA82.1] Maternal care for breech presentation
Also known as: Maternal care for breech presentation | breech fetal presentation | breech presentation | malposition of fetus in breech presentation | positions of breech presentation
[JA82.Z] Maternal care for malpresentation of fetus, unspecified
Also known as: Maternal care for malpresentation of fetus, unspecified | Maternal care for malpresentation of fetus | abnormal fetal presentation | malpresentation of fetus | fetal malpresentation
[JA82.6] Maternal care for compound presentation
Also known as: Maternal care for compound presentation | compound presentation of fetus
[JA82.5] Maternal care for multiple gestation with malpresentation of one fetus or more
Also known as: Maternal care for multiple gestation with malpresentation of one fetus or more | abnormal presentation in multiple gestation
=== GRAPH WALKS ===
--- Walk 1 ---
[FA5Z] Arthropathies, unspecified
--PARENT--> [?] Arthropathies
--CHILD--> [?] Infection related arthropathies
Def: A disease of the joints, caused by an infection with a bacterial, viral, fungal, or parasitic source.
Distinction is made between the following types of etiological relationship.
a) direct infection ...
--- Walk 2 ---
[FA5Z] Arthropathies, unspecified
--PARENT--> [?] Arthropathies
--CHILD--> [?] Inflammatory arthropathies
--- Walk 3 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--CHILD--> [?] Soft tissue disorders
--- Walk 4 ---
[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified
--PARENT--> [15] Diseases of the musculoskeletal system or connective tissue
Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....
--EXCLUDES--> [?] Pregnancy, childbirth or the puerperium
Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...
--- Walk 5 ---
[ME60.Z] Skin lesion of unspecified nature
--PARENT--> [ME60] Skin lesion of uncertain or unspecified nature
Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...
--CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature
Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made....
--- Walk 6 ---
[ME60.Z] Skin lesion of unspecified nature
--PARENT--> [ME60] Skin lesion of uncertain or unspecified nature
Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...
--CHILD--> [ME60.2] Ulcer of skin of uncertain nature
Def: This denotes the presence of a skin ulcer but uncertainty as to its nature. No inference as to whether the ulcer might be of serious significance (e.g. suspected skin cancer) is made....
|
[
"[FA5Z] Arthropathies, unspecified\n --PARENT--> [?] Arthropathies\n --CHILD--> [?] Infection related arthropathies\n Def: A disease of the joints, caused by an infection with a bacterial, viral, fungal, or parasitic source.\n\nDistinction is made between the following types of etiological relationship.\na) direct infection ...",
"[FA5Z] Arthropathies, unspecified\n --PARENT--> [?] Arthropathies\n --CHILD--> [?] Inflammatory arthropathies",
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --CHILD--> [?] Soft tissue disorders",
"[FC0Z] Diseases of the musculoskeletal system or connective tissue, unspecified\n --PARENT--> [15] Diseases of the musculoskeletal system or connective tissue\n Def: This chapter contains diseases of musculoskeletal system and diseases of connective tissue....\n --EXCLUDES--> [?] Pregnancy, childbirth or the puerperium\n Def: A group of conditions characterised as occurring during the period of time from conception to delivery (pregnancy), during labour and delivery (childbirth) or during the approximately six weeks after ...",
"[ME60.Z] Skin lesion of unspecified nature\n --PARENT--> [ME60] Skin lesion of uncertain or unspecified nature\n Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...\n --CHILD--> [ME60.1] Pigmented skin lesion of uncertain nature\n Def: This denotes the presence of a pigmented skin lesion but uncertainty as to its nature. No inference as to whether the lesion might be of serious significance (e.g. suspected skin cancer) is made....",
"[ME60.Z] Skin lesion of unspecified nature\n --PARENT--> [ME60] Skin lesion of uncertain or unspecified nature\n Def: To be used where there is either significant uncertainty or alternatively no information as to the nature of a circumscribed skin lesion. This is of particular importance with regard to whether or not...\n --CHILD--> [ME60.2] Ulcer of skin of uncertain nature\n Def: This denotes the presence of a skin ulcer but uncertainty as to its nature. No inference as to whether the ulcer might be of serious significance (e.g. suspected skin cancer) is made...."
] |
FA5Z
|
Arthropathies, unspecified
|
[
{
"from_icd11": "FA5Z",
"icd10_code": "M00-M25",
"icd10_title": ""
},
{
"from_icd11": "FC0Z",
"icd10_code": "XIII",
"icd10_title": ""
},
{
"from_icd11": "ME60.Z",
"icd10_code": "L989",
"icd10_title": "Disorder of the skin and subcutaneous tissue, unspecified"
},
{
"from_icd11": "MD41",
"icd10_code": "R911",
"icd10_title": "Solitary pulmonary nodule"
},
{
"from_icd11": "MD41",
"icd10_code": "R91",
"icd10_title": "Abnormal findings on diagnostic imaging of lung"
},
{
"from_icd11": "JA82.2",
"icd10_code": "O322XX2",
"icd10_title": "Maternal care for transverse and oblique lie, fetus 2"
},
{
"from_icd11": "JA82.2",
"icd10_code": "O322XX0",
"icd10_title": "Maternal care for transverse and oblique lie, not applicable or unspecified"
},
{
"from_icd11": "JA82.2",
"icd10_code": "O322XX1",
"icd10_title": "Maternal care for transverse and oblique lie, fetus 1"
},
{
"from_icd11": "JA82.2",
"icd10_code": "O322",
"icd10_title": "Maternal care for transverse and oblique lie"
},
{
"from_icd11": "JA82.1",
"icd10_code": "O321XX2",
"icd10_title": "Maternal care for breech presentation, fetus 2"
},
{
"from_icd11": "JA82.1",
"icd10_code": "O321XX1",
"icd10_title": "Maternal care for breech presentation, fetus 1"
},
{
"from_icd11": "JA82.1",
"icd10_code": "O321XX3",
"icd10_title": "Maternal care for breech presentation, fetus 3"
},
{
"from_icd11": "JA82.1",
"icd10_code": "O321XX0",
"icd10_title": "Maternal care for breech presentation, not applicable or unspecified"
},
{
"from_icd11": "JA82.1",
"icd10_code": "O321",
"icd10_title": "Maternal care for breech presentation"
},
{
"from_icd11": "JA82.Z",
"icd10_code": "O328XX1",
"icd10_title": "Maternal care for other malpresentation of fetus, fetus 1"
}
] |
M00-M25
| |
There are many factors in the etiology of masseter hypertrophy, such as tensions and clenching caused by emotional stress and parafunctional habits. It is observed that none of the etiologic factors in the literature are present in our patient such as dental attrition, and therefore, we can refer to this condition as idiopathic masseter hypertrophy. Especially in the diagnosis of the clinical situation in unilateral hypertrophy, the differential diagnosis of head and neck soft tissue pathologies should be made . Before deciding on the treatment plan, MR and CT, thanks to their high imaging capacity, should be used to exclude possible pathologies such as muscle tumors, salivary gland disorders, parotid tumors, parotid inflammatory diseases, and intrinsic masseter myopathy. MR images of the patient in our case showed that the masseter muscle and surrounding soft tissues had a regular structure, but the right masseter muscle was significantly larger than the left side. Also, in panoramic radiographs of the patient, reactive bone formation and significant asymmetry compared to the left side were observed in response to the abnormal activity of the masseter muscle in the mandibular angular region on the right side. After the patient was diagnosed with MH, two options for treatment became prominent. One of them is the injection of botulinum toxin type A, and the other one is the respective surgery of the masseter muscle and angulus of the mandible. The use of botulinum toxin in the treatment of masseter hypertrophy is a frequently preferred treatment option since 1994. The minimally invasive nature of this procedure and the fact that the risk ratio is meager are the most important reasons why botulinum toxin is used for many years with success for cosmetic purposes . In the literature, botulinum toxin has been shown to cause muscle atrophy by blocking neurotransmission at the neurotransmitter junction. But, as the botulinum toxin activity declines over time, atrophic muscle tends to return to its former size, as neural conduction in the neurotransmitter junction will return to normal, so the injection should be repeated approximately every 4–8 months; however, there are various techniques and protocols for extending this lasting duration in the literature , which constitutes the biggest disadvantage of botulinum toxin treatment . On the other hand, surgical treatment, although providing more permanent results than botulinum toxin, has various complication risks such as hematoma formation, facial nerve paralysis, infection, mouth opening limitation, and appearance of scar . After discussing the possible advantages and risks of both treatment options with the patient, botulinum toxin application was agreed as the first treatment option. 75 units of botulinum toxin was given at the first visit. One month later, at the second visit, 60 units of botulinum toxin were applied to the muscle. After six months, it was observed that the muscles had diminished to the initial position, but the symmetrical condition was still found to be unsatisfactory by the patient, and the surgical option was on the table. Some authors claim the partial removal of the masseter muscle is enough to correct MH. According to Beckers, the insertion of hypertrophic masseter muscle causes an abnormal growing mandibular angle. Other authors confirmed that, in order to reach satisfactory results, a mandibular angle resection should be performed [ 5 , 7 – 10 ]. In our case, a more permanent and lighter facial contouring could be achieved compared to botulinum toxin treatment since the surgical procedure entails removing an appropriate amount of tissue from the mandibular angle and masseter muscle, and this can be observed when the patient's profile photographs, panoramic graphs, and MR images were taken before and after the surgery are compared . In the literature, it is widely accepted that, to correct the MH, the resection of the inferior belly of the masseter muscle and angulus of the mandible should be performed with the intraoral approach [ 9 – 11 ]. However, despite the easy access to the inferior belly of the masseter muscle when using the intraoral approach, since the angulus of the mandibular is located in the thickest part of the operative area and the strong tension of the masseter muscle makes retraction very difficult, the surgeon's vision is limited in a sagittal direction . In our case, taking this limited access to the mandibular angular region when using the intraoral approach into account and since under these circumstances making the bone cut in the desired amount would be extremely difficult, the extraoral submandibular approach was chosen during the bone resection. The primary disadvantage of the extraoral approach is the risk of a scar on the face. The skin incision should be thrown parallel to the Langers lines and should be kept as short as possible to minimize this risk . We have experienced no complication and scar with removal of the enlarged mandibular angle when using the combination of extraoral and intraoral approaches.
| 4.191406
| 0.785156
|
sec[2]/p[0]
|
en
| 0.999999
|
29850280
|
https://doi.org/10.1155/2018/7168472
|
[
"masseter",
"muscle",
"botulinum",
"toxin",
"mandibular",
"that",
"this",
"approach",
"hypertrophy",
"literature"
] |
[
{
"code": "FB3Z",
"title": "Disorders of muscles, unspecified"
},
{
"code": "FB32.Y",
"title": "Other specified disorders of muscles"
},
{
"code": "8C70.Z",
"title": "Muscular dystrophy, unspecified"
},
{
"code": "FB32.2Z",
"title": "Ischaemic infarction of muscle, unspecified"
},
{
"code": "FB56.2",
"title": "Myalgia"
},
{
"code": "1A11.Z",
"title": "Botulism, unspecified"
},
{
"code": "1A11.0",
"title": "Foodborne intoxication by botulinum toxin"
},
{
"code": "EL73.2",
"title": "Adverse reaction to injection of neurotoxin"
},
{
"code": "8D88.3",
"title": "Autonomic disorder due to toxins"
},
{
"code": "8A00.2Y",
"title": "Other specified secondary parkinsonism"
}
] |
=== ICD-11 CODES FOUND ===
[FB3Z] Disorders of muscles, unspecified
Also known as: Disorders of muscles, unspecified | disorder of muscle, unspecified | muscle disease | muscular disease | muscular disorder
[FB32.Y] Other specified disorders of muscles
Also known as: Other specified disorders of muscles | Muscle wasting or atrophy, not elsewhere classified | muscle wasting | muscle wasting disorder | Sarcopenia
[8C70.Z] Muscular dystrophy, unspecified
Also known as: Muscular dystrophy, unspecified | Muscular dystrophy | Gower's muscular dystrophy | progressive musclular dystrophy | pseudohypertrophic atrophy
[FB32.2Z] Ischaemic infarction of muscle, unspecified
Also known as: Ischaemic infarction of muscle, unspecified | Ischaemic infarction of muscle | muscle infarction
[FB56.2] Myalgia
Definition: This is a disorder characterised by pain in a muscle or group of muscles.
Also known as: Myalgia | muscle ache | muscle soreness | muscular pain | myalgic
Excludes: Chronic primary musculoskeletal pain | Chronic secondary musculoskeletal pain
[1A11.Z] Botulism, unspecified
Also known as: Botulism, unspecified | Botulism | clostridium botulinum poisoning | intoxication with clostridium botulinum toxin | botulism NOS
[1A11.0] Foodborne intoxication by botulinum toxin
Also known as: Foodborne intoxication by botulinum toxin | foodborne intoxication due to Clostridium botulinum | Foodborne Clostridium botulinum toxin intoxication
[EL73.2] Adverse reaction to injection of neurotoxin
Definition: Adverse event resulting from use of neurotoxins, especially botulinum toxin, into the skin. This is most commonly administered for aesthetic reasons. Recognised problems include ptosis, diplopia and hypersensitivity to the toxin. Details of the reaction should be coded separately.
Also known as: Adverse reaction to injection of neurotoxin | Adverse reaction to injection of botulinum toxin
[8D88.3] Autonomic disorder due to toxins
Also known as: Autonomic disorder due to toxins | Autonomic dysfunction due to medications | Autonomic dysfunction due to heavy metal exposure | Autonomic dysfunction due to Vacor exposure | Autonomic dysfunction due to Acrylamide exposure
[8A00.2Y] Other specified secondary parkinsonism
Also known as: Other specified secondary parkinsonism | Parkinsonism associated with hydrocephalus | Toxin-induced parkinsonism | secondary parkinsonism due to other external agents | Manganese-induced Parkinsonism
=== GRAPH WALKS ===
--- Walk 1 ---
[FB3Z] Disorders of muscles, unspecified
--PARENT--> [?] Disorders of muscles
--CHILD--> [FB31] Calcification or ossification of muscle
--- Walk 2 ---
[FB3Z] Disorders of muscles, unspecified
--PARENT--> [?] Disorders of muscles
--CHILD--> [FB32] Certain specified disorders of muscle
Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....
--- Walk 3 ---
[FB32.Y] Other specified disorders of muscles
--PARENT--> [FB32] Certain specified disorders of muscle
Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....
--EXCLUDES--> [?] Myalgia
Def: This is a disorder characterised by pain in a muscle or group of muscles....
--- Walk 4 ---
[FB32.Y] Other specified disorders of muscles
--PARENT--> [FB32] Certain specified disorders of muscle
Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....
--EXCLUDES--> [?] Myalgia
Def: This is a disorder characterised by pain in a muscle or group of muscles....
--- Walk 5 ---
[8C70.Z] Muscular dystrophy, unspecified
--PARENT--> [8C70] Muscular dystrophy
Def: Progressive, hereditary skeletal muscle diseases characterised by muscle weakness, wasting, defects in muscle proteins, necrosis of muscle tissue and replacement of muscle tissue with connective and f...
--RELATED_TO--> [?] Muscular dystrophy affecting extraocular muscle
Def: Non-specific term that is used to describe a range of primary myopathies that affect the extraocular muscles....
--- Walk 6 ---
[8C70.Z] Muscular dystrophy, unspecified
--PARENT--> [8C70] Muscular dystrophy
Def: Progressive, hereditary skeletal muscle diseases characterised by muscle weakness, wasting, defects in muscle proteins, necrosis of muscle tissue and replacement of muscle tissue with connective and f...
--RELATED_TO--> [?] Barth syndrome
Def: Barth syndrome is an inborn error of phospholipid metabolism characterised by dilated cardiomyopathy (DCM), skeletal myopathy, neutropaenia, growth delay and organic aciduria....
|
[
"[FB3Z] Disorders of muscles, unspecified\n --PARENT--> [?] Disorders of muscles\n --CHILD--> [FB31] Calcification or ossification of muscle",
"[FB3Z] Disorders of muscles, unspecified\n --PARENT--> [?] Disorders of muscles\n --CHILD--> [FB32] Certain specified disorders of muscle\n Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....",
"[FB32.Y] Other specified disorders of muscles\n --PARENT--> [FB32] Certain specified disorders of muscle\n Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....\n --EXCLUDES--> [?] Myalgia\n Def: This is a disorder characterised by pain in a muscle or group of muscles....",
"[FB32.Y] Other specified disorders of muscles\n --PARENT--> [FB32] Certain specified disorders of muscle\n Def: This is an impairment of health or a condition of abnormal functioning of the muscle that does not fit in another category....\n --EXCLUDES--> [?] Myalgia\n Def: This is a disorder characterised by pain in a muscle or group of muscles....",
"[8C70.Z] Muscular dystrophy, unspecified\n --PARENT--> [8C70] Muscular dystrophy\n Def: Progressive, hereditary skeletal muscle diseases characterised by muscle weakness, wasting, defects in muscle proteins, necrosis of muscle tissue and replacement of muscle tissue with connective and f...\n --RELATED_TO--> [?] Muscular dystrophy affecting extraocular muscle\n Def: Non-specific term that is used to describe a range of primary myopathies that affect the extraocular muscles....",
"[8C70.Z] Muscular dystrophy, unspecified\n --PARENT--> [8C70] Muscular dystrophy\n Def: Progressive, hereditary skeletal muscle diseases characterised by muscle weakness, wasting, defects in muscle proteins, necrosis of muscle tissue and replacement of muscle tissue with connective and f...\n --RELATED_TO--> [?] Barth syndrome\n Def: Barth syndrome is an inborn error of phospholipid metabolism characterised by dilated cardiomyopathy (DCM), skeletal myopathy, neutropaenia, growth delay and organic aciduria...."
] |
FB3Z
|
Disorders of muscles, unspecified
|
[
{
"from_icd11": "FB3Z",
"icd10_code": "M60831",
"icd10_title": "Other myositis, right forearm"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60869",
"icd10_title": "Other myositis, unspecified lower leg"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60811",
"icd10_title": "Other myositis, right shoulder"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6080",
"icd10_title": "Other myositis, unspecified site"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60851",
"icd10_title": "Other myositis, right thigh"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6010",
"icd10_title": "Interstitial myositis of unspecified site"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6018",
"icd10_title": "Interstitial myositis, other site"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6088",
"icd10_title": "Other myositis, other site"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60862",
"icd10_title": "Other myositis, left lower leg"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60861",
"icd10_title": "Other myositis, right lower leg"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M6089",
"icd10_title": "Other myositis, multiple sites"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60852",
"icd10_title": "Other myositis, left thigh"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60821",
"icd10_title": "Other myositis, right upper arm"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60871",
"icd10_title": "Other myositis, right ankle and foot"
},
{
"from_icd11": "FB3Z",
"icd10_code": "M60812",
"icd10_title": "Other myositis, left shoulder"
}
] |
M60831
|
Other myositis, right forearm
|
Written, informed consent was obtained from the patient for publication of this case report and accompanying images. A 55-year-old man (height, 170.5 cm; body weight, 66.8 kg; American Society of Anesthesiologists physical status class II) with glioma of the right temporal lobe was scheduled for craniotomy and tumor resection under general anesthesia. He had a history of smoking (Brinkmann Index 300), but no personal or family history of ischemic heart disease. There were no abnormalities in relation to his neurological findings and basic activities of daily life (ADL) before surgery. And no symptoms of intracranial hypertension were found. Preoperative 12-lead electrocardiography (ECG) showed complete right bundle branch block and WPW syndrome with delta waves. Other preoperative examinations including chest X-rays, pulmonary function tests, and blood analyses showed no abnormalities. The patient was taken to the operating room without premedication, where standard monitoring was applied, including ECG leads (focused on lead II) , non-invasive blood pressure (BP), and pulse oximetry. After peripheral vein cannulation, anesthesia was induced with 0.3 μg/kg/min of remifentanil and 120 mg of propofol. Endotracheal intubation followed after administration of 60 mg of rocuronium. Anesthesia was maintained using 3–5% desflurane in a 40% oxygen/air mixture and 0.1–0.2 μg/kg/min of the remifentanil infusion. The left radial artery was cannulated for invasive arterial blood pressure measurement and collection of blood for analysis. The patient was then placed in the prone position. After rigid head fixation, comprising insertion of three metal pins, surgery was started. About 2 h later, during excision of the cerebral dura mater, the ECG monitor displayed sudden premature ventricular contractions (PVCs) with wide QRS complexes and ventricular bigeminy . The peripheral blood oxygen saturation (SpO 2 ) was 100% and end Tidal CO 2 (ETCO 2 ) was 38 mmHg immediately before the arrhythmia. And bispectral index (BIS) value was 31–38 before the arrhythmia. These were not preceded by changes in heart rate (HR) or arterial blood pressure (HR 80 beats min, arterial blood pressure (ABP) 94/47 mmHg) and disappeared completely after intravenous administration of 50 mg lidocaine while surgery was temporarily interrupted. However, as soon as surgery resumed, the ECG monitor showed marked ST segment elevation lasting about 2 min (HR 80 beats min, ABP 82/45 mmHg) . Intravenous nicorandil (2 mg/h) was administered, and the procedure abandoned after considering the perioperative risk factors, such as possible severe underlying cardiac pathology and the risk of surgery in the prone position. The serum potassium level of arterial blood gas analysis was normal (4.1 mmoL/L, normal range 3.5–5.0 mmoL/L). Approximately 13 min later, during closure of the dura mater, the ECG monitor again showed ST segment elevation followed by sustained ventricular tachycardia . The patient’s blood pressure was unmeasurable shortly afterwards. Though cardioversion was once thought to be hard to perform in the prone position, the entire episode lasted about 1 min and resolved spontaneously. Since pseudo-VT with WPW syndrome was suspected, a continuous infusion of pilsicainide, a Class I(c) antiarrhythmic, was started at 22 mg/kg/min. Once surgery concluded the patient was immediately turned from the prone to the supine position and transferred to the intensive care unit. The patient had an uneventful recovery, with normal postoperative 12-lead ECG and cardiac enzyme measurements (including creatine kinase and lactate dehydrogenase). Two weeks after surgery, a spasm provocation test with acetylcholine was performed, which showed complete spastic occlusion of the right coronary artery, and this confirmed the possible diagnosis of the intraoperative ST elevation due to coronary vasospasm. Postoperatively, the patient agreed to further evaluation of his intraoperative symptoms. While an electrophysiological study showed the presence of a posterolateral accessory pathway, consistent with the preoperative diagnosis of WPW syndrome, the anterograde effective refractory period (ERP) of the abnormal accessory pathway was noted to be relatively long (540 ms). The patient underwent successful catheter ablation using radiofrequency current, and his posttreatment ECG showed resolution of the inferior Q waves. Three months later, the patient underwent successful reoperation using preoperative antiplatelet therapy and perioperative nicorandil infusion. Fig. 1 Preoperative electrocardiogram. The tracing of lead II showed complete right bundle branch block and delta waves with WPW syndrome Fig. 2 Intraoperative monitor (ECG, pulse oximetry, ABP) after surgery was started. The ECG monitor showed sudden premature ventricular contractions (PVCs) with wide QRS complexes and ventricular bigeminy Fig. 3 The ECG monitor showed marked ST segment elevation Fig. 4 The ECG monitor again showed ST segment elevation followed by sustained ventricular tachycardia. And ABP was unmeasurable
| 4.039063
| 0.97168
|
sec[1]/p[0]
|
en
| 0.999997
|
32025977
|
https://doi.org/10.1186/s40981-019-0233-2
|
[
"blood",
"monitor",
"ventricular",
"preoperative",
"pressure",
"elevation",
"lead",
"arterial",
"prone",
"position"
] |
[
{
"code": "3C0Z",
"title": "Diseases of the blood or blood-forming organs, unspecified"
},
{
"code": "MF50.4Z",
"title": "Haematuria, unspecified"
},
{
"code": "MA12.1",
"title": "Finding of cocaine in blood"
},
{
"code": "MA12.4",
"title": "Finding of steroid agent in blood"
},
{
"code": "MA12.2",
"title": "Finding of hallucinogen in blood"
},
{
"code": "PL14.1",
"title": "Non provision of necessary procedure"
},
{
"code": "KA42.3",
"title": "Monitoring injury of scalp of newborn"
},
{
"code": "PK95.0",
"title": "Neurological devices associated with injury or harm, diagnostic or monitoring devices"
},
{
"code": "PK97.0",
"title": "Ophthalmic devices associated with injury or harm, diagnostic or monitoring devices"
},
{
"code": "PK9C.0",
"title": "Other or unspecified medical devices associated with injury or harm, diagnostic or monitoring devices"
}
] |
=== ICD-11 CODES FOUND ===
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
Also known as: Diseases of the blood or blood-forming organs, unspecified | Blood, lymph or spleen disease | blood condition NOS | blood disorder NOS | bone marrow disease NOS
[MF50.4Z] Haematuria, unspecified
Also known as: Haematuria, unspecified | Haematuria | blood in urine | urinary blood | haematuria NOS
[MA12.1] Finding of cocaine in blood
Also known as: Finding of cocaine in blood | cocaine in blood
[MA12.4] Finding of steroid agent in blood
Also known as: Finding of steroid agent in blood | steroid in blood
[MA12.2] Finding of hallucinogen in blood
Also known as: Finding of hallucinogen in blood | hallucinogen in blood
[PL14.1] Non provision of necessary procedure
Also known as: Non provision of necessary procedure | Nonadministration of surgical and medical care | injury due to nonadministration of surgical and medical care | Premature cessation of surgical and medical care | Failure to introduce or to remove other tube or instrument
Excludes: Delayed treatment
[KA42.3] Monitoring injury of scalp of newborn
Definition: Injuries to the scalp from use of intrapartum fetal monitoring devices including injury following fetal blood sampling.
Also known as: Monitoring injury of scalp of newborn | Injury to scalp of newborn due to sampling incision | Sampling incision of scalp of newborn | Injury to scalp of newborn due to scalp clip or electrode | fetal scalp electrode injury
[PK95.0] Neurological devices associated with injury or harm, diagnostic or monitoring devices
Also known as: Neurological devices associated with injury or harm, diagnostic or monitoring devices | Neurological devices associated with injury or harm, lumbar puncture needle | Neurological devices associated with adverse incidents, LP -[lumbar puncture] needle | Neurological devices associated with injury or harm, intracranial pressure monitor | Neurological devices associated with adverse incidents, ICP - [intracranial pressure monitor]
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
[PK97.0] Ophthalmic devices associated with injury or harm, diagnostic or monitoring devices
Definition: An ophthalmic device was involved in an incident that occurred in a diagnostic or monitoring task
Also known as: Ophthalmic devices associated with injury or harm, diagnostic or monitoring devices | Ophthalmic devices associated with adverse incidents, slit lamp | Ophthalmic devices associated with adverse incidents, retinal camera | Ophthalmic devices associated with adverse incidents, opthalmoscope | Ophthalmic devices associated with adverse incidents, tonometer
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
[PK9C.0] Other or unspecified medical devices associated with injury or harm, diagnostic or monitoring devices
Also known as: Other or unspecified medical devices associated with injury or harm, diagnostic or monitoring devices
Excludes: Circumstances associated with a surgical or other medical device influencing the episode of care without injury or harm
=== GRAPH WALKS ===
--- Walk 1 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Certain conditions originating in the perinatal period
Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....
--- Walk 2 ---
[3C0Z] Diseases of the blood or blood-forming organs, unspecified
--PARENT--> [03] Diseases of the blood or blood-forming organs
Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....
--EXCLUDES--> [?] Diseases of the immune system
--- Walk 3 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.4Z] Haematuria, unspecified
--- Walk 4 ---
[MF50.4Z] Haematuria, unspecified
--PARENT--> [MF50.4] Haematuria
Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...
--CHILD--> [MF50.41] Microscopic haematuria
--- Walk 5 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.1] Finding of cocaine in blood
--- Walk 6 ---
[MA12.1] Finding of cocaine in blood
--PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system
--CHILD--> [MA12.2] Finding of hallucinogen in blood
|
[
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Certain conditions originating in the perinatal period\n Def: This chapter includes conditions that have their origin in the perinatal period even though death or morbidity occurs later....",
"[3C0Z] Diseases of the blood or blood-forming organs, unspecified\n --PARENT--> [03] Diseases of the blood or blood-forming organs\n Def: This chapter includes diseases of the blood as well as diseases of blood forming organs....\n --EXCLUDES--> [?] Diseases of the immune system",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.4Z] Haematuria, unspecified",
"[MF50.4Z] Haematuria, unspecified\n --PARENT--> [MF50.4] Haematuria\n Def: Hematuria means presence of blood or red blood cells (RBCs) in the urine. There are two types of hematuria: gross hematuria (when one can see the blood in the urine) and microscopic hematuria (when th...\n --CHILD--> [MF50.41] Microscopic haematuria",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.1] Finding of cocaine in blood",
"[MA12.1] Finding of cocaine in blood\n --PARENT--> [MA12] Clinical findings of drugs, medicaments and biological substances in blood, blood-forming organs, or the immune system\n --CHILD--> [MA12.2] Finding of hallucinogen in blood"
] |
3C0Z
|
Diseases of the blood or blood-forming organs, unspecified
|
[
{
"from_icd11": "3C0Z",
"icd10_code": "D75A",
"icd10_title": "Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7581",
"icd10_title": "Myelofibrosis"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7582",
"icd10_title": "Heparin induced thrombocytopenia (HIT)"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D7589",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D759",
"icd10_title": "Disease of blood and blood-forming organs, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D763",
"icd10_title": "Other histiocytosis syndromes"
},
{
"from_icd11": "3C0Z",
"icd10_code": "Q899",
"icd10_title": "Congenital malformation, unspecified"
},
{
"from_icd11": "3C0Z",
"icd10_code": "III",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D70-D77",
"icd10_title": ""
},
{
"from_icd11": "3C0Z",
"icd10_code": "D75",
"icd10_title": "Other and unspecified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D77",
"icd10_title": "Other disorders of blood and blood-forming organs in diseases classified elsewhere"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D758",
"icd10_title": "Other specified diseases of blood and blood-forming organs"
},
{
"from_icd11": "3C0Z",
"icd10_code": "D76",
"icd10_title": "Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R310",
"icd10_title": "Gross hematuria"
},
{
"from_icd11": "MF50.4Z",
"icd10_code": "R312",
"icd10_title": "Other microscopic hematuria"
}
] |
D75A
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
|
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